Details of the Drug

General Information of Drug (ID: DMV8EXG)

• Drug Name: PolyHeme
• Synonyms: Oxygen-carrying blood substitute, Northfield Laboratories

Indication

Disease Entry	ICD 11	Status	REF
Blood forming organ disorder	JB64.1	Phase 3	[1]

• #Ro5 Violations (Lipinski): 0:
  Molecular Weight; 347.26
  Logarithm of the Partition Coefficient; Not Available
  Rotatable Bond Count; 8
  Hydrogen Bond Donor Count; 3
  Hydrogen Bond Acceptor Count; 9
• Chemical Identifiers:
  Formula: C13H18NO8P
  IUPAC Name: (4-formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate;pentanedial
  Canonical SMILES: CC1=NC=C(C(=C1O)C=O)COP(=O)(O)O.C(CC=O)CC=O
  InChI: InChI=1S/C8H10NO6P.C5H8O2/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14;6-4-2-1-3-5-7/h2-3,11H,4H2,1H3,(H2,12,13,14);4-5H,1-3H2
  InChIKey: SKKYPUWZZNPUMG-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 72941846
  TTD ID: D00IWL

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Hemoglobin (HB)	TTQO71U	HBA_HUMAN	Modulator	[2]

References

• [1] ClinicalTrials.gov (NCT00076648) Safety and Efficacy of PolyHeme(R) in Hemorrhagic Shock Following Traumatic Injuries Beginning in the Pre-Hospital Setting. U.S. National Institutes of Health.
• [2] Blood substitutes- the polyheme trials. Mcgill J Med. 2008 January; 11(1): 59-65.