Details of the Drug

General Information of Drug (ID: DMV8EXG)

Drug Name

PolyHeme

Synonyms

Oxygen-carrying blood substitute, Northfield Laboratories

Indication

Disease Entry	ICD 11	Status	REF
Blood forming organ disorder	JB64.1	Phase 3	[1]
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Structure

3D MOL is unavailable

2D MOL

#Ro5 Violations (Lipinski):
0

Molecular Weight

347.26

Logarithm of the Partition Coefficient

Not Available

Rotatable Bond Count

8

Hydrogen Bond Donor Count

3

Hydrogen Bond Acceptor Count

9

Chemical Identifiers

Formula: C13H18NO8P
IUPAC Name: (4-formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate;pentanedial
Canonical SMILES: CC1=NC=C(C(=C1O)C=O)COP(=O)(O)O.C(CC=O)CC=O
InChI: InChI=1S/C8H10NO6P.C5H8O2/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14;6-4-2-1-3-5-7/h2-3,11H,4H2,1H3,(H2,12,13,14);4-5H,1-3H2
InChIKey: SKKYPUWZZNPUMG-UHFFFAOYSA-N

Cross-matching ID

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This Drug

References

1	ClinicalTrials.gov (NCT00076648) Safety and Efficacy of PolyHeme(R) in Hemorrhagic Shock Following Traumatic Injuries Beginning in the Pre-Hospital Setting. U.S. National Institutes of Health.
2	Blood substitutes- the polyheme trials. Mcgill J Med. 2008 January; 11(1): 59-65.