Details of the Drug

General Information of Drug (ID: DMVFK3J)

Drug Name
PFI-1
Synonyms QCR-192; HY-16586; PF-6405761
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL is unavailable 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 347.4
Logarithm of the Partition Coefficient (xlogp) 1.2
Rotatable Bond Count (rotbonds) 4
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 5
Chemical Identifiers
Formula
C16H17N3O4S
IUPAC Name
2-methoxy-N-(3-methyl-2-oxo-1,4-dihydroquinazolin-6-yl)benzenesulfonamide
Canonical SMILES
CN1CC2=C(C=CC(=C2)NS(=O)(=O)C3=CC=CC=C3OC)NC1=O
InChI
InChI=1S/C16H17N3O4S/c1-19-10-11-9-12(7-8-13(11)17-16(19)20)18-24(21,22)15-6-4-3-5-14(15)23-2/h3-9,18H,10H2,1-2H3,(H,17,20)
InChIKey
TXZPMHLMPKIUGK-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
71271629
ChEBI ID
CHEBI:95079
CAS Number
1403764-72-6
TTD ID
D03LNF

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Bromodomain-containing protein 4 (BRD4) TTRA6BO BRD4_HUMAN Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Actin, aortic smooth muscle (ACTA2) OTEDLG8E ACTA_HUMAN Gene/Protein Processing [2]
Collagen alpha-1(I) chain (COL1A1) OTI31178 CO1A1_HUMAN Gene/Protein Processing [2]
Collagen alpha-1(V) chain (COL5A1) OT24078H CO5A1_HUMAN Gene/Protein Processing [2]
Collagen alpha-2(I) chain (COL1A2) OTY7G382 CO1A2_HUMAN Gene/Protein Processing [2]
Fibrillin-1 (FBN1) OTYCJT63 FBN1_HUMAN Gene/Protein Processing [2]
Fibronectin (FN1) OTB5ZN4Q FINC_HUMAN Gene/Protein Processing [2]
Integrin alpha-1 (ITGA1) OTDITIST ITA1_HUMAN Gene/Protein Processing [2]
Integrin alpha-4 (ITGA4) OTSCAL0V ITA4_HUMAN Gene/Protein Processing [2]
Integrin alpha-5 (ITGA5) OT3RCI67 ITA5_HUMAN Gene/Protein Processing [2]
Integrin beta-1 (ITGB1) OT6G1IAR ITB1_HUMAN Gene/Protein Processing [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Bromodomain-containing protein 4 (BRD4) DTT BRD4 3.27E-01 0.02 0.04
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1; GDSC2 3.9129 6.18 2.3504 4.6306
EW-22 GDSC1; GDSC2 2.8771 6.8063 1.1964 14.7221
TC-71 GDSC1; GDSC2 3.0955 9.1601 0.2121 19.5568
ES5 GDSC1; GDSC2 3.2722 8.5313 0.6757 16.5213
NOS-1 [Human HNSCC] GDSC1; GDSC2 3.4071 6.8682 1.6192 10.5088
MG-63 GDSC1; GDSC2 3.4289 7.3916 1.3755 11.9481
ES4 GDSC1; GDSC2 3.5896 6.3889 2.0054 7.5851
SJSA-1 GDSC1; GDSC2 3.6277 7.1976 1.6326 9.8101
EW-3 GDSC1; GDSC2 3.697 8.2495 1.1634 12.4736
CHSA0011 GDSC1; GDSC2 3.7638 6.0824 2.2904 5.3526
A-673 GDSC1; GDSC2 3.7924 7.9774 1.3737 10.9536
EW-24 GDSC1; GDSC2 3.8741 6.9335 1.9531 7.1802
ES1 GDSC1; GDSC2 3.944 7.3456 1.8021 7.942
SK-ES-1 GDSC1; GDSC2 3.988 7.1339 1.9386 6.9934
CHSA0108 GDSC1; GDSC2 3.9886 10.2787 0.3823 16.0698
ES7 GDSC1; GDSC2 4.0286 9.1856 0.9562 12.7973
CAL-72 GDSC1; GDSC2 4.091 11.1441 0.0319 17.5821
ES8 GDSC1; GDSC2 4.0997 10.041 0.5865 14.6802
EW-16 GDSC1; GDSC2 4.1849 7.6622 1.8221 7.2446
CHSA8926 GDSC1; GDSC2 4.2675 7.6017 1.9096 6.5267
HuO-3N1 GDSC1; GDSC2 4.2785 8.9493 1.2602 10.3969
HuO9 GDSC1; GDSC2 4.3787 9.8884 0.8724 12.3858
HOS GDSC1; GDSC2 4.4249 12.034 -0.1525 17.5988
EW-12 GDSC2 4.4613 7.2352 2.2138 4.3111
SK-PN-DW GDSC1; GDSC2 4.4905 10.0449 0.8776 12.0838
H-EMC-SS GDSC1; GDSC2 4.5297 7.3143 2.2201 4.1456
MHH-ES-1 GDSC1; GDSC2 4.7027 11.079 0.5253 13.4959
EW-1 GDSC1; GDSC2 4.8766 7.5064 2.3393 2.8965
SaOS-2 GDSC1; GDSC2 4.8866 9.4891 1.4246 8.0674
CADO-ES1 GDSC1; GDSC2 5.0553 6.9365 2.6738 1.0655
G-292 clone A141B1 GDSC1; GDSC2 5.0823 9.968 1.3266 8.2243
EW-11 GDSC1; GDSC2 5.1072 13.8543 -0.5406 17.6942
EW-13 GDSC1; GDSC2 5.1587 7.2344 2.6018 1.2678
ES6 GDSC1; GDSC2 5.1748 16.9927 -2.0374 23.2251
EW-18 GDSC1; GDSC2 5.2 8.7379 1.9728 4.3712
NY GDSC1; GDSC2 5.3405 12.5873 0.2446 13.4758
U2OS GDSC1; GDSC2 5.4272 10.44 1.3271 7.5457
EW-7 GDSC1; GDSC2 5.7179 7.6481 2.6847 0.5584
CAL-78 GDSC1; GDSC2 6.5291 14.7913 -0.0108 12.2761
U-CH2 GDSC2 6.6222 8.3277 2.7784 0.1101
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 168 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC1; GDSC2 3.1938 5.5015 2.1236 7.9674
Kasumi-1 GDSC1; GDSC2 0.5543 2.8988 0.4056 28.5329
OCI-AML-3 GDSC1 0.6953 3.1319 0.5049 33.9654
H9 GDSC1; GDSC2 1.1693 4.1672 0.6977 24.1268
MV4-11 GDSC1; GDSC2 1.22 4.0679 0.7884 23.4082
CRO-AP2 GDSC1; GDSC2 1.2716 3.4944 1.035 21.8273
697 GDSC1; GDSC2 1.3841 3.2669 1.2219 20.298
BC-1 GDSC1; GDSC2 1.4411 5.4256 0.4694 24.186
NCI-H929 GDSC1; GDSC2 1.4888 5.2995 0.5736 23.4269
WIL2 NS GDSC1; GDSC2 1.5617 3.9396 1.2028 19.6078
CMK GDSC1 1.5991 3.721 1.3194 23.3916
SU-DHL-10 GDSC1; GDSC2 1.7633 3.6758 1.5126 16.9883
NB4 GDSC1; GDSC2 1.779 3.8296 1.4765 17.1225
A3/Kawakami GDSC1; GDSC2 1.8218 2.9996 1.7602 15.3717
Mono-Mac-6 GDSC1; GDSC2 1.8268 5.5248 0.8165 20.7131
MOLM-16 GDSC1; GDSC2 1.8717 3.9008 1.5506 16.3029
DG-75 GDSC1; GDSC2 1.872 5.4618 0.8906 20.1141
SK-MM-2 GDSC1; GDSC2 1.8975 5.5561 0.873 20.1147
OPM-2 GDSC1; GDSC2 1.9749 4.0147 1.6181 15.478
JVM-2 GDSC1; GDSC2 2.0425 5.9349 0.8402 19.7449
KMOE-2 GDSC1; GDSC2 2.0838 11.3549 -1.7679 30.9759
JVM-3 GDSC1; GDSC2 2.1226 6.3378 0.7265 20.089
SU-DHL-16 GDSC1; GDSC2 2.1379 3.5798 1.9512 12.8851
KMS-12-BM GDSC2 2.1727 3.7042 1.9459 12.7628
KMS-11 GDSC1; GDSC2 2.1805 5.8784 1.0013 18.2982
RPMI-8866 GDSC1; GDSC2 2.1988 5.0393 1.4112 15.8015
WSU-NHL GDSC1; GDSC2 2.2259 4.7395 1.5745 14.721
TALL-1 [Human adult T-ALL] GDSC2 2.2374 5.928 1.0328 17.9037
MOLM-13 GDSC1; GDSC2 2.3506 4.308 1.8926 12.3368
NOMO-1 GDSC1; GDSC2 2.3577 4.6996 1.7257 13.3083
OCI-M1 GDSC1; GDSC2 2.3611 3.3983 2.2515 10.2238
SUP-B8 GDSC1; GDSC2 2.3617 8.1179 0.0832 22.6475
MOLT-13 GDSC1; GDSC2 2.3761 6.1094 1.0785 17.1321
Karpas-45 GDSC1; GDSC2 2.3891 4.2758 1.9462 11.8665
HH [Human lymphoma] GDSC1; GDSC2 2.4036 9.0263 -0.3276 24.4555
THP-1 GDSC1; GDSC2 2.4279 5.8081 1.273 15.787
EoL-1 GDSC1; GDSC2 2.4757 4.0989 2.112 10.5391
RPMI-8402 GDSC1; GDSC2 2.5011 5.9885 1.2552 15.6348
A4/Fukuda GDSC1; GDSC2 2.5042 4.4585 1.9826 11.2013
HEL GDSC1; GDSC2 2.5603 5.2264 1.6789 12.8454
MLMA GDSC1; GDSC2 2.6006 6.4143 1.14 15.9811
SKM-1 GDSC1; GDSC2 2.6018 6.0009 1.3434 14.7516
BONNA-12 GDSC2 2.6025 6.4237 1.1371 15.9921
Ku812 GDSC1; GDSC2 2.6054 6.357 1.1725 15.7699
LC4-1 GDSC1; GDSC2 2.6244 5.0278 1.8354 11.6552
HAL-01 GDSC1; GDSC2 2.6352 6.2361 1.2593 15.1461
OCI-AML-2 GDSC1; GDSC2 2.6414 5.2001 1.7691 12.003
RCH-ACV GDSC1; GDSC2 2.6622 5.5772 1.6064 12.9336
Namalwa GDSC1; GDSC2 2.6624 6.1641 1.3196 14.6884
GR-ST GDSC1; GDSC2 2.6643 8.4136 0.2092 20.9686
Jiyoye GDSC1; GDSC2 2.6949 5.1367 1.8507 11.3115
Daudi GDSC1; GDSC2 2.7725 5.8877 1.5566 12.8653
P30/OHK GDSC1; GDSC2 2.779 4.0888 2.4272 7.4705
JJN-3 GDSC1; GDSC2 2.7847 5.9359 1.5441 12.9021
P31/FUJ GDSC1; GDSC2 2.8792 6.959 1.1225 15.1585
ST486 GDSC1; GDSC2 2.9263 5.659 1.8092 10.7882
KG-1 GDSC1; GDSC2 2.9271 6.3371 1.4739 12.8689
KY821 GDSC1; GDSC2 2.9404 6.3236 1.4924 12.7121
GDM-1 GDSC1; GDSC2 2.9788 5.8905 1.7415 11.0413
BL-41 GDSC1; GDSC2 2.9948 5.4923 1.9534 9.6631
GA-10 GDSC1; GDSC2 2.9989 7.0959 1.1594 14.5548
HL-60 GDSC1; GDSC2 3.0054 4.9439 2.2341 7.8664
MOLT-16 GDSC1; GDSC2 3.0083 6.6256 1.402 13.0527
KOPN-8 GDSC1; GDSC2 3.0181 7.1795 1.1344 14.6441
SU-DHL-5 GDSC1; GDSC2 3.0276 4.5963 2.4254 6.594
MEG-01 GDSC1; GDSC2 3.0307 5.6085 1.9277 9.7089
SUP-T1 GDSC1; GDSC2 3.0615 7.51 1.0071 15.2634
EM-2 GDSC1; GDSC2 3.0658 6.2061 1.6612 11.268
L-540 GDSC1; GDSC2 3.0702 6.1654 1.6854 11.1033
BV-173 GDSC1; GDSC2 3.0847 4.8485 2.353 6.8614
MOLP-8 GDSC1; GDSC2 3.108 6.5298 1.5364 11.9127
AMO1 GDSC1; GDSC2 3.1333 4.6337 2.5029 5.7613
NALM-6 GDSC1; GDSC2 3.1343 5.7264 1.96 9.1818
CA46 GDSC1; GDSC2 3.1423 6.5892 1.5363 11.8082
L-363 GDSC1; GDSC2 3.1678 7.8417 0.9324 15.3724
Karpas-620 GDSC1; GDSC2 3.1843 6.7769 1.4785 12.0379
L-1236 GDSC1; GDSC2 3.1845 5.7668 1.9832 8.8814
MHH-CALL-4 GDSC2 3.186 6.158 1.7891 10.0978
ARH-77 GDSC1; GDSC2 3.2284 6.059 1.8747 9.4328
NU-DUL-1 GDSC1; GDSC2 3.2284 4.5174 2.6446 4.5681
RPMI-8226 GDSC1; GDSC2 3.2391 5.8744 1.976 8.7625
MN-60 GDSC1; GDSC2 3.2402 7.2619 1.2834 13.0635
NKM-1 GDSC1; GDSC2 3.2479 6.6529 1.5944 11.1287
SU-DHL-6 GDSC1; GDSC2 3.2724 4.9798 2.4514 5.6574
OCI-Ly7 GDSC1; GDSC2 3.2838 5.212 2.3449 6.2976
Sc-1 GDSC1 3.303 7.2266 1.3538 15.3363
SCC-3 GDSC2 3.3099 6.452 1.7469 9.9938
MC116 GDSC1; GDSC2 3.3248 4.9891 2.4908 5.254
Karpas-1106P GDSC1; GDSC2 3.3257 5.6273 2.1724 7.2665
VAL GDSC1; GDSC2 3.331 5.2676 2.3566 6.0857
P32/ISH GDSC1; GDSC2 3.3325 7.0441 1.4696 11.6508
SUP-M2 GDSC1; GDSC2 3.351 4.7833 2.6153 4.3899
Loucy GDSC1; GDSC2 3.3547 7.8676 1.0763 13.9652
RL GDSC1; GDSC2 3.3747 4.727 2.6629 4.0219
DB GDSC1; GDSC2 3.3826 6.5277 1.7693 9.6424
KE-37 GDSC1; GDSC2 3.3879 5.0215 2.5265 4.8477
WSU-DLCL2 GDSC1; GDSC2 3.3911 5.573 2.2535 6.5659
BALL-1 GDSC1; GDSC2 3.4013 4.9116 2.5922 4.3948
HT GDSC1; GDSC2 3.4069 8.3197 0.8935 14.8809
QIMR-WIL GDSC1; GDSC2 3.4147 6.0783 2.0203 7.9723
JeKo-1 GDSC1; GDSC2 3.428 7.3492 1.396 11.8261
CTB-1 GDSC1; GDSC2 3.4393 5.7634 2.1976 6.7842
HC-1 GDSC1; GDSC2 3.4431 5.7744 2.1951 6.7889
DEL GDSC1; GDSC2 3.4519 6.5431 1.8183 9.1381
JSC-1 GDSC2 3.462 5.203 2.4954 4.8396
IM-9 GDSC1; GDSC2 3.4766 5.9079 2.1555 6.9465
PL-21 GDSC1; GDSC2 3.481 6.8585 1.6844 9.8935
DND-41 GDSC1; GDSC2 3.5201 5.2809 2.5024 4.6407
PF-382 GDSC1; GDSC2 3.533 6.658 1.8264 8.8615
SU-DHL-8 GDSC1; GDSC2 3.5584 5.9767 2.1861 6.5321
CCRF-CEM GDSC1; GDSC2 3.5633 6.6802 1.8394 8.6973
Jurkat GDSC1; GDSC2 3.5659 6.3738 1.9942 7.7189
SUP-HD1 GDSC1; GDSC2 3.5681 5.8435 2.2599 6.041
VL51 GDSC1; GDSC2 3.571 9.0001 0.6877 15.5744
MY-M12 GDSC2 3.5719 6.6151 1.8788 8.4272
Karpas-299 GDSC1; GDSC2 3.5891 6.6245 1.8877 8.3249
TUR GDSC1; GDSC2 3.5972 12.326 -0.9528 23.3574
RPMI-6666 GDSC1; GDSC2 3.6051 7.2254 1.6009 10.0681
Karpas-422 GDSC1; GDSC2 3.6092 8.1968 1.1196 12.9774
ATN-1 GDSC1; GDSC2 3.6207 7.9049 1.2745 12.0195
YT GDSC1; GDSC2 3.6254 7.3222 1.5687 10.2115
BC-3 GDSC2 3.6388 6.5195 1.9789 7.6206
ALL-SIL GDSC1; GDSC2 3.6614 6.8036 1.8553 8.334
DoHH2 GDSC2 3.6748 5.4912 2.5155 4.1669
Raji GDSC1; GDSC2 3.6914 5.8774 2.3375 5.2372
SR GDSC1; GDSC2 3.711 5.9279 2.3273 5.2524
CTV-1 GDSC1; GDSC2 3.7247 6.3828 2.1128 6.5591
RS4;11 GDSC1; GDSC2 3.758 6.3834 2.1377 6.32
P12-Ichikawa GDSC1; GDSC2 3.7633 7.0107 1.8313 8.2172
NK-92MI GDSC2 3.8063 6.5845 2.0746 6.5928
Hs 445 GDSC1; GDSC2 3.8243 11.941 -0.5764 21.1418
CESS GDSC1; GDSC2 3.8261 6.8928 1.9373 7.3979
ML-2 GDSC1; GDSC2 3.8377 5.6761 2.542 3.6246
HDLM-2 GDSC1; GDSC2 3.8522 9.3002 0.7624 14.37
MHH-PREB-1 GDSC1; GDSC2 3.8609 9.5755 0.6322 15.0702
Reh GDSC1; GDSC2 3.8783 6.0286 2.3996 4.4069
KCL-22 GDSC1; GDSC2 3.9023 10.2516 0.3281 16.5895
L-428 GDSC1; GDSC2 3.9655 5.8408 2.55 3.3023
JURL-MK1 GDSC1; GDSC2 3.9747 7.3323 1.8313 7.6864
OCI-AML-5 GDSC1; GDSC2 4.003 8.2414 1.4042 10.2228
K-562 GDSC1; GDSC2 4.0316 8.1577 1.467 9.7719
BE-13 GDSC1; GDSC2 4.0395 6.8972 2.0912 5.9335
LP-1 GDSC1; GDSC2 4.0696 7.5371 1.8003 7.6483
MOLT-4 GDSC1; GDSC2 4.076 9.771 0.7022 14.1068
MM1.S GDSC2 4.0802 14.3303 -1.5638 24.32
OCI-Ly19 GDSC1; GDSC2 4.0981 7.0211 2.0724 5.9153
SU-DHL-1 GDSC2 4.1128 9.0053 1.1094 11.6929
ME1 GDSC1; GDSC2 4.154 8.6016 1.3394 10.2329
ROS-50 GDSC1; GDSC2 4.2467 6.8714 2.2461 4.5442
CML-T1 GDSC1; GDSC2 4.247 5.9945 2.6552 2.1702
TK [Human B-cell lymphoma] GDSC1; GDSC2 4.2934 6.9106 2.2583 4.377
Ramos.2G6.4C10 GDSC1; GDSC2 4.3817 8.8966 1.3608 9.5577
SIG-M5 GDSC2 4.4421 5.501 2.9649 0.4515
LAMA-84 GDSC1; GDSC2 4.4589 6.869 2.3826 3.3409
U-698-M GDSC1; GDSC2 4.4795 7.144 2.2679 3.9621
EB2 GDSC1; GDSC2 4.4941 6.2471 2.682 1.6581
Granta-519 GDSC1; GDSC2 4.5681 6.1689 2.7539 1.2148
U266B1 GDSC1; GDSC2 4.592 8.3609 1.7662 6.6875
SU-DHL-4 GDSC1; GDSC2 4.6573 6.2251 2.7744 1.025
EJM GDSC1; GDSC2 4.7241 12.6389 -0.2259 17.1924
EHEB GDSC1 4.7743 7.2686 2.3872 3.4797
Farage GDSC1; GDSC2 4.8171 11.1128 0.5913 12.874
SUP-B15 GDSC2 4.8643 6.6336 2.7066 1.1103
ALL-PO GDSC1; GDSC2 4.8973 11.5249 0.4477 13.4445
Karpas-231 GDSC1; GDSC2 4.9569 6.4867 2.8069 0.6374
MHH-CALL-2 GDSC1; GDSC2 5.3277 7.087 2.7349 0.6308
RC-K8 GDSC1; GDSC2 5.7295 16.577 -1.422 19.8331
KM-H2 GDSC1; GDSC2 5.7642 7.7784 2.6551 0.6195
⏷ Show the Full List of 168 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ESO-26 GDSC1; GDSC2 3.3657 6.1999 1.9193 8.7488
OACM5.1 C GDSC1; GDSC2 3.4032 5.2621 2.4187 5.4864
OACP4 C GDSC1; GDSC2 3.9591 6.3315 2.3094 4.7777
KYSE-50 GDSC1; GDSC2 3.9905 6.7826 2.1122 5.9174
FLO-1 GDSC1; GDSC2 4.0322 14.3179 -1.596 24.5602
ESO-51 GDSC1; GDSC2 4.0851 7.0068 2.0703 5.9577
KYAE-1 GDSC1; GDSC2 4.3514 8.4015 1.5806 8.3206
HCE-4 GDSC1; GDSC2 4.4504 8.521 1.5922 8.027
TE-12 GDSC1; GDSC2 4.6426 7.8274 2.0518 4.9092
KYSE-220 GDSC1; GDSC2 4.9437 7.8983 2.2023 3.5313
SK-GT-4 GDSC1; GDSC2 5.525 16.4659 -1.5167 20.6337
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1; GDSC2 4.0462 9.4607 0.8332 13.4521
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NB69 GDSC1; GDSC2 1.1858 6.1948 -0.1333 28.2733
CHP-212 GDSC1; GDSC2 2.1272 4.5699 1.5486 15.2618
SJNB-12 GDSC1 2.7117 7.1302 0.8881 20.8962
IMR-5 GDSC1; GDSC2 3.0981 8.5658 0.5112 17.964
SK-N-AS GDSC1; GDSC2 3.1291 6.6714 1.4839 12.1727
SK-N-BE(2)-M17 GDSC1; GDSC2 3.1345 6.4871 1.5806 11.5574
GI-ME-N GDSC1; GDSC2 3.1413 9.6207 0.0208 20.379
GOTO GDSC1; GDSC2 3.2156 9.4997 0.144 19.5328
SK-N-DZ GDSC1; GDSC2 3.2452 11.8999 -1.0311 24.6976
KP-N-YN GDSC1; GDSC2 3.3335 11.0237 -0.5193 22.313
SiMa GDSC1 3.6389 8.4414 1.0213 16.4273
SK-N-FI GDSC1; GDSC2 3.7558 9.0935 0.7892 14.4832
SJNB-10 GDSC1; GDSC2 3.8072 8.4228 1.1637 12.1722
SJNB-6 GDSC1; GDSC2 3.9374 6.1798 2.3677 4.4692
TGW GDSC1; GDSC2 3.9489 5.8939 2.5135 3.5572
NH-12 GDSC1; GDSC2 4.0394 6.342 2.3599 4.2934
SJNB-14 GDSC1; GDSC2 4.08 5.9742 2.5618 3.0032
SJNB-13 GDSC1; GDSC2 4.176 6.5144 2.369 3.9547
CHP-126 GDSC1; GDSC2 4.2766 6.4684 2.4553 3.2531
Kelly GDSC1; GDSC2 4.5257 11.0194 0.4245 14.4585
KP-N-YS GDSC2 4.7338 7.9151 2.0682 4.6441
SJNB-5 GDSC1; GDSC2 4.743 7.9367 2.0639 4.6521
LA-N-6 GDSC1; GDSC2 4.7506 7.1366 2.4325 2.5898
SK-N-MC-IXC GDSC1; GDSC2 4.9246 6.3356 2.8508 0.5106
SK-N-SH GDSC1; GDSC2 5.1342 10.8563 0.9371 10.2902
NB1 GDSC1; GDSC2 5.1851 14.4786 -0.79 18.5789
SJNB-17 GDSC2 5.3025 7.3409 2.6256 1.0405
SJNB-7 GDSC1; GDSC2 5.3474 14.2507 -0.5602 17.2233
NB(TU)1 GDSC1 5.4253 7.0018 2.8057 0.4658
KP-N-RT-BM-1 GDSC2 5.5346 8.0092 2.465 1.4826
MHH-NB-11 GDSC2 5.7892 7.4579 2.7809 0.2903
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC1; GDSC2 3.5868 6.927 1.7351 9.2845
Cancer Drug Sensitivity Data Curated from 52 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCC2157 GDSC1; GDSC2 1.9093 4.3508 1.4145 16.9272
MCF-7 GDSC1; GDSC2 3.1889 6.7257 1.5079 11.8422
HCC1599 GDSC2 3.4659 5.259 2.4706 4.9859
Hs 578T GDSC1; GDSC2 3.4744 7.5394 1.3388 12.0417
Evsa-T GDSC1; GDSC2 3.6377 9.2803 0.6016 15.8609
EFM-19 GDSC1; GDSC2 3.7544 10.1946 0.239 17.4629
CAL-120 GDSC1; GDSC2 3.7812 9.0658 0.8232 14.2209
MDA-MB-453 GDSC1; GDSC2 3.8038 6.8301 1.9515 7.3659
BT-474 GDSC1; GDSC2 3.854 11.2702 -0.218 19.435
MDA-MB-231 GDSC1; GDSC2 3.8691 11.811 -0.4757 20.5731
HCC1428 GDSC1; GDSC2 3.8739 10.0174 0.4223 16.1708
MFM-223 GDSC1; GDSC2 3.901 6.1846 2.3398 4.7231
HCC2218 GDSC1; GDSC2 3.9695 6.2802 2.3416 4.5575
HCC1569 GDSC1; GDSC2 3.9825 8.8423 1.0911 12.1356
HCC38 GDSC1; GDSC2 3.9919 8.3961 1.3192 10.7611
EFM-192A GDSC1; GDSC2 3.997 8.1818 1.4291 10.0878
MDA-MB-468 GDSC1; GDSC2 3.9997 6.5825 2.2161 5.2581
CAL-148 GDSC2 4.0135 6.1127 2.4523 3.7901
CAL-51 GDSC1; GDSC2 4.1321 9.8603 0.701 13.967
HCC1143 GDSC1; GDSC2 4.21 7.2196 2.0543 5.7767
T-47D GDSC1; GDSC2 4.2492 7.5857 1.9047 6.5974
MDA-MB-361 GDSC1; GDSC2 4.2741 10.896 0.2962 15.764
UACC-812 GDSC2 4.3055 14.9185 -1.6784 24.1327
MDA-MB-157 GDSC1; GDSC2 4.3188 9.0456 1.2424 10.4041
OCUB-M GDSC1; GDSC2 4.337 11.0487 0.2684 15.7448
BT-549 GDSC1; GDSC2 4.401 15.2133 -1.7501 24.1354
YMB-1-E GDSC2 4.4878 7.831 1.9494 5.8178
MDA-MB-415 GDSC1; GDSC2 4.4902 13.339 -0.7494 20.1049
AU565 GDSC1; GDSC2 4.5363 8.6014 1.6129 7.7139
BT-20 GDSC1; GDSC2 4.5398 6.6554 2.5274 2.4024
BT-483 GDSC1 4.5701 10.4518 0.7362 15.2525
HCC1419 GDSC1; GDSC2 4.5737 9.0958 1.4 8.8869
HCC1500 GDSC1; GDSC2 4.6076 8.4474 1.7353 6.8375
CAL-85-1 GDSC1; GDSC2 4.676 14.3588 -1.1127 21.113
HCC1187 GDSC1; GDSC2 4.7445 11.9277 0.1393 15.3806
DU4475 GDSC1; GDSC2 4.7488 6.8475 2.5582 1.9414
HCC70 GDSC1; GDSC2 4.7588 6.9949 2.4995 2.2271
COLO 824 GDSC1; GDSC2 4.7724 11.1861 0.5234 13.3401
HCC202 GDSC1 4.9518 8.1292 2.1025 5.0495
HCC1395 GDSC1; GDSC2 5.0769 9.1707 1.6986 6.1209
MDA-MB-330 GDSC1; GDSC2 5.0959 7.5147 2.4542 2.0102
MRK-nu-1 GDSC1; GDSC2 5.1354 6.7815 2.7701 0.6401
HDQ-P1 GDSC1; GDSC2 5.2277 15.033 -1.0312 19.4643
MDA-MB-175-VII GDSC1; GDSC2 5.6071 7.3822 2.7384 0.4655
HCC1806 GDSC1; GDSC2 5.6333 15.8035 -1.1131 18.8678
HCC1954 GDSC1; GDSC2 5.6483 7.306 2.7819 0.339
UACC-893 GDSC1; GDSC2 5.7802 8.1786 2.5094 1.0953
MDA-MB-436 GDSC1; GDSC2 5.7849 14.1872 -0.2203 14.7378
CAMA-1 GDSC1; GDSC2 5.8103 14.1814 -0.2 14.5904
ZR-75-30 GDSC1; GDSC2 5.866 8.2739 2.5098 1.0294
JIMT-1 GDSC1; GDSC2 5.8868 15.7533 -0.9076 17.4933
HCC1937 GDSC1; GDSC2 7.9882 21.3292 -2.1527 17.9706
⏷ Show the Full List of 52 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 55 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
GI-1 GDSC1; GDSC2 2.7056 5.9231 1.4777 13.5769
8-MG-BA GDSC1; GDSC2 2.7311 9.0199 -0.0333 21.9601
H4 GDSC1; GDSC2 2.9326 9.7022 -0.1982 22.0938
MOG-G-UVW GDSC1; GDSC2 3.0687 5.5077 2.0114 9.0627
CAS-1 GDSC1; GDSC2 3.299 7.5698 1.1789 13.5187
DK-MG GDSC1; GDSC2 3.3783 5.91 2.0745 7.7337
M059J GDSC1; GDSC2 3.3856 6.2768 1.8973 8.8303
SF295 GDSC1; GDSC2 3.4969 5.866 2.1926 6.6564
D-566MG GDSC1; GDSC2 3.5097 9.4073 0.4342 17.1384
Daoy GDSC1; GDSC2 3.5181 4.9364 2.6718 3.5798
D283 Med GDSC1; GDSC2 3.5633 5.734 2.3106 5.7345
D-263MG GDSC1; GDSC2 3.6508 8.4522 1.0255 13.4153
YH-13 GDSC1; GDSC2 3.6813 8.5027 1.0246 13.3356
KS-1 [Human Krukenberg tumour] GDSC1; GDSC2 3.7753 9.0936 0.8047 14.3417
KALS-1 GDSC1; GDSC2 3.7922 9.2044 0.7628 14.532
SF126 GDSC1; GDSC2 3.8357 6.6867 2.0462 6.6968
ONS-76 GDSC1; GDSC2 3.8589 7.7646 1.5307 9.824
Onda 10 GDSC1; GDSC2 3.91 7.1632 1.8666 7.6275
YKG-1 GDSC1; GDSC2 3.9426 5.9391 2.4875 3.7275
42-MG-BA GDSC1; GDSC2 3.9618 10.2487 0.3763 16.1743
PFSK-1 GDSC1; GDSC2 3.9757 6.768 2.1087 5.9735
SK-MG-1 GDSC1; GDSC2 4.0093 8.7536 1.1555 11.6884
Hs 683 GDSC1; GDSC2 4.0132 6.1251 2.4462 3.8278
U-118MG GDSC1; GDSC2 4.0194 7.8296 1.6197 8.8747
U-87MG ATCC GDSC1; GDSC2 4.0646 10.1003 0.53 15.0785
LNZTA3WT4 GDSC1; GDSC2 4.0742 7.2296 1.9541 6.6948
NMC-G1 GDSC1; GDSC2 4.0873 7.1217 2.0159 6.2855
LN-229 GDSC1; GDSC2 4.1009 8.4256 1.3866 10.0827
D-423MG GDSC1; GDSC2 4.1135 7.1347 2.0282 6.1505
D-502MG GDSC1; GDSC2 4.1427 6.228 2.4827 3.347
KNS-81-FD GDSC1; GDSC2 4.1936 6.8229 2.2337 4.7284
D-336MG GDSC1; GDSC2 4.2444 6.9679 2.1986 4.8335
D-392MG GDSC1; GDSC2 4.2538 8.58 1.4232 9.4905
LN-405 GDSC1; GDSC2 4.3082 9.1305 1.1929 10.7196
MOG-G-CCM GDSC1; GDSC2 4.3259 7.7995 1.8545 6.7305
D-542MG GDSC1; GDSC2 4.3574 10.2352 0.6857 13.4755
SW1088 GDSC1; GDSC2 4.3859 9.7432 0.949 11.9352
SF539 GDSC1; GDSC2 4.4335 11.2514 0.2411 15.6383
KNS-42 GDSC1; GDSC2 4.4422 10.0733 0.8282 12.4772
Onda 11 GDSC1; GDSC2 4.4585 8.0197 1.8395 6.5336
LN-18 GDSC1; GDSC2 4.4625 9.6645 1.0436 11.2111
SNB-75 GDSC1; GDSC2 4.6811 9.0361 1.5029 8.0481
D-247MG GDSC1; GDSC2 4.7775 7.2836 2.3824 2.8169
GB-1 GDSC1; GDSC2 4.7994 9.3488 1.4331 8.2017
SW1783 GDSC1; GDSC2 4.9472 12.442 0.0352 15.408
AM-38 GDSC1; GDSC2 5.0614 7.5189 2.4345 2.1495
GaMG GDSC1; GDSC2 5.5319 12.4517 0.4416 12.0693
Becker GDSC1; GDSC2 5.7225 14.2395 -0.2888 15.1837
SF268 GDSC1; GDSC2 5.797 14.3526 -0.2918 15.0381
A-172 GDSC1; GDSC2 6.1839 14.9273 -0.3037 14.2882
T98G GDSC1; GDSC2 6.2868 18.3679 -1.8961 20.3319
U-251MG GDSC1; GDSC2 6.4753 24.4156 -4.7261 27.5134
D-245MG GDSC2 6.8444 9.5673 2.4274 0.7042
KINGS-1 GDSC1; GDSC2 8.3071 20.9415 -1.7604 16.1092
DBTRG-05MG GDSC1; GDSC2 8.647 19.781 -1.0069 12.8177
⏷ Show the Full List of 55 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ETK-1 GDSC1; GDSC2 3.3505 7.4739 1.2697 12.8194
TGBC24TKB GDSC1; GDSC2 3.789 7.9759 1.3718 10.9745
TGBC1TKB GDSC1; GDSC2 4.5051 9.8464 0.9855 11.4405
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KLE GDSC1; GDSC2 3.6947 10.4279 0.0746 18.4657
RL95-2 GDSC1; GDSC2 4.128 6.1717 2.4998 3.2752
MFE-319 GDSC1; GDSC2 4.2369 8.7201 1.3422 10.0132
ESS-1 GDSC1; GDSC2 4.2782 7.9975 1.7252 7.6184
MFE-280 GDSC1; GDSC2 4.4568 6.924 2.3559 3.4968
EN GDSC1; GDSC2 4.7657 6.8012 2.5871 1.7757
AN3-CA GDSC1; GDSC2 4.8828 14.9507 -1.2483 21.1297
MFE-296 GDSC1; GDSC2 5.7755 15.1786 -0.707 16.9016
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 33 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CAL-54 GDSC1; GDSC2 3.3 8.0681 0.9305 14.9831
Caki-1 GDSC1; GDSC2 3.3119 8.1751 0.887 15.2002
LB1047-RCC GDSC1; GDSC2 3.3242 5.0185 2.4755 5.3526
BFTC-909 GDSC1; GDSC2 3.7992 8.5938 1.0724 12.732
TK-10 GDSC1; GDSC2 3.8179 11.7777 -0.5 20.8241
UO-31 GDSC1; GDSC2 3.8442 6.9887 1.9035 7.5628
LB2241-RCC GDSC1; GDSC2 3.9576 6.1198 2.4108 4.1616
LB996-RCC GDSC1; GDSC2 3.9582 7.3004 1.8348 7.7051
KTCTL-1M GDSC1; GDSC2 4.0336 7.1672 1.9553 6.7823
A-704 GDSC1; GDSC2 4.0559 7.4584 1.8289 7.5055
VMRC-RCW GDSC2 4.0736 5.9763 2.5567 3.0458
SW156 GDSC1; GDSC2 4.1419 6.4141 2.3942 3.8735
HA7-RCC GDSC1; GDSC2 4.1625 6.5821 2.3279 4.2278
KTCTL-21 GDSC1; GDSC2 4.1651 7.0025 2.1281 5.4275
KTCTL-13 GDSC1; GDSC2 4.1848 7.8986 1.7068 7.9462
BB65-RCC GDSC1; GDSC2 4.1861 7.6468 1.8305 7.191
KTCTL-26A GDSC1; GDSC2 4.285 6.7945 2.3077 4.1012
SW13 GDSC1; GDSC2 4.5656 9.6334 1.133 10.4558
KMRC-1 GDSC1; GDSC2 4.6765 8.6994 1.6611 7.1303
NCC021 GDSC1; GDSC2 4.7472 6.6416 2.6455 1.5156
A-498 GDSC1; GDSC2 4.8068 6.6851 2.6573 1.391
KTCTL-140 GDSC1; GDSC2 4.8153 7.2201 2.4317 2.4992
KTCTL-195 GDSC1; GDSC2 4.9354 12.0408 0.2231 14.5058
OS-RC-2 GDSC1; GDSC2 4.9986 10.9348 0.8061 11.3022
786-O GDSC1; GDSC2 5.1403 19.8903 -3.4999 27.4459
RXF 393L GDSC1; GDSC2 5.3474 7.7277 2.4906 1.5586
NCC010 GDSC1; GDSC2 5.5327 7.9975 2.4688 1.4685
VMRC-RCZ GDSC1; GDSC2 5.6 12.5808 0.4258 12.0065
769-P GDSC1; GDSC2 6.3359 15.1927 -0.3285 14.0937
SN12C GDSC1; GDSC2 6.7648 15.9968 -0.4271 13.6957
KMRC-20 GDSC1; GDSC2 6.8227 15.3258 -0.0736 12.0182
ACHN GDSC1; GDSC2 6.9163 15.4581 -0.0761 11.8595
RCC10RGB GDSC2 7.0468 26.6002 -5.3776 27.7806
⏷ Show the Full List of 33 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 48 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-407 GDSC1; GDSC2 3.1311 6.0236 1.809 10.141
NCI-H747 GDSC1; GDSC2 3.144 7.967 0.8495 15.9256
NCI-H716 GDSC1; GDSC2 3.2594 6.3831 1.7389 10.1928
SW48 GDSC1; GDSC2 3.2729 8.5273 0.6783 16.5047
HCT 116 GDSC1; GDSC2 3.4504 6.4459 1.8657 8.8446
RKO GDSC1; GDSC2 3.4834 9.0107 0.6109 16.2543
COLO205 GDSC1; GDSC2 3.5106 6.6923 1.7912 9.1439
NCI-H508 GDSC1; GDSC2 3.5195 6.0902 2.0988 7.1867
SNU-175 GDSC2 3.5196 6.9692 1.6603 9.9357
HT-29 GDSC1; GDSC2 3.5461 7.7044 1.3146 11.9854
C2BBe1 GDSC1; GDSC2 3.5686 5.5759 2.3933 5.2
CL-11 GDSC1; GDSC2 3.6542 8.5089 0.9998 13.5557
HT115 GDSC1; GDSC2 3.7593 6.6921 1.986 7.263
RCM-1 [Human ESC] GDSC1; GDSC2 3.8324 7.2367 1.772 8.4077
SW626 GDSC1; GDSC2 3.835 9.636 0.5816 15.419
SNU-C5 GDSC1; GDSC2 3.8431 6.8149 1.9885 7.0372
SNU-C1 GDSC1; GDSC2 3.8439 11.9881 -0.5842 21.121
DiFi GDSC1; GDSC2 3.8699 6.521 2.1529 5.9504
SW837 GDSC1; GDSC2 3.8737 7.4164 1.7144 8.6586
HCC2998 GDSC1; GDSC2 3.8804 9.3518 0.7589 14.3128
KM12 GDSC1; GDSC2 3.9033 6.0443 2.4096 4.2891
GP5d GDSC1; GDSC2 3.9196 6.8359 2.0347 6.5635
HT-55 GDSC1; GDSC2 3.9318 8.8493 1.0486 12.517
LS411N GDSC1; GDSC2 3.9501 7.1255 1.9149 7.2304
SNU-283 GDSC2 3.967 10.7676 0.1221 17.4685
SW1116 GDSC1; GDSC2 3.9734 7.2026 1.8941 7.3028
COLO 678 GDSC1; GDSC2 3.9879 7.3217 1.8463 7.5621
LoVo GDSC1; GDSC2 4.0044 7.5931 1.725 8.2672
SNU-61 GDSC1; GDSC2 4.0452 7.5351 1.7835 7.8094
CCK-81 GDSC1; GDSC2 4.0702 6.8702 2.1261 5.6501
LS1034 GDSC1; GDSC2 4.1951 7.2329 2.0377 5.9106
SNU-C2B GDSC1; GDSC2 4.2766 8.1883 1.6312 8.189
SNU-1040 GDSC1 4.3072 8.7742 1.3669 11.892
HCT 15 GDSC1; GDSC2 4.3147 6.9607 2.2484 4.393
SK-CO-1 GDSC1; GDSC2 4.4159 6.5505 2.5026 2.7382
LS513 GDSC1; GDSC2 4.4748 9.4971 1.1344 10.6603
COLO 320HSR GDSC1; GDSC2 4.4921 6.3974 2.6151 2.0068
MDST8 GDSC1; GDSC2 4.5174 8.5082 1.6448 7.5661
CaR-1 GDSC1; GDSC2 4.6026 7.4568 2.1993 4.1309
LS123 GDSC1; GDSC2 4.676 6.7641 2.5552 2.0558
SW1417 GDSC1; GDSC2 4.9121 10.9987 0.7145 11.9939
CW-2 GDSC1; GDSC2 5.0825 7.6221 2.4012 2.287
SW1463 GDSC1; GDSC2 5.1006 12.1924 0.2674 13.8996
SNU-81 GDSC1; GDSC2 5.2381 6.9337 2.7555 0.6209
LS180 GDSC1; GDSC2 5.6697 7.4001 2.7563 0.3911
T84 GDSC1; GDSC2 5.7487 7.8351 2.6276 0.7125
SW948 GDSC1; GDSC2 5.8858 7.3735 2.845 0.1524
SW620 GDSC1; GDSC2 6.3811 15.6753 -0.5288 14.881
⏷ Show the Full List of 48 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1; GDSC2 3.6692 6.5589 1.983 7.5149
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Hep 3B2.1-7 GDSC1; GDSC2 3.4424 7.3696 1.3976 11.7747
Hep-G2/C3A GDSC1; GDSC2 3.5734 6.7687 1.8034 8.8953
JHH-7 GDSC1; GDSC2 3.6403 7.7529 1.3659 11.4127
HLE GDSC1; GDSC2 3.8462 6.4237 2.1833 5.8191
JHH-6 GDSC1; GDSC2 3.9584 14.3604 -1.6763 25.0345
JHH-1 GDSC1; GDSC2 3.9722 11.5971 -0.287 19.4306
HuH-1 GDSC1; GDSC2 4.5207 6.8578 2.4249 2.9955
SNU-423 GDSC1; GDSC2 4.6487 11.3535 0.3511 14.5384
SNU-387 GDSC1; GDSC2 5.6098 14.7219 -0.6022 16.817
SNU-449 GDSC1; GDSC2 5.8973 12.328 0.7417 9.7891
SNU-398 GDSC1; GDSC2 6.0922 15.8381 -0.8049 16.6371
JHH-2 GDSC1; GDSC2 6.1443 14.5599 -0.1547 13.6918
Huh-7 GDSC1; GDSC2 6.4233 18.7319 -1.9763 20.3239
JHH-4 GDSC1; GDSC2 7.2236 14.4072 0.5943 8.2198
SK-HEP-1 GDSC1; GDSC2 8.9864 23.9446 -2.737 18.1274
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 186 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCC44 GDSC1 1.847 6.3941 0.4327 27.6756
EBC-1 GDSC1; GDSC2 2.1678 5.8108 1.021 18.2299
SBC-1 GDSC1; GDSC2 2.2174 5.7826 1.0826 17.6846
EPLC-272H GDSC1; GDSC2 2.6586 10.0042 -0.5869 24.7327
NCI-H847 GDSC1; GDSC2 2.6597 5.8985 1.4473 13.9195
RERF-LC-KJ GDSC1; GDSC2 2.7159 13.3749 -2.2181 30.2766
SBC-3 GDSC1; GDSC2 2.7316 6.0483 1.4401 13.7194
A-549 GDSC1; GDSC2 2.8739 6.2603 1.4645 13.0993
NCI-H2795 GDSC1; GDSC2 2.9432 5.3932 1.9559 9.8146
NCI-H292 GDSC1; GDSC2 2.9807 6.9632 1.2096 14.3108
UMC-11 GDSC1; GDSC2 3.0211 5.6897 1.8788 10.0467
NCI-H211 GDSC1 3.0426 6.5736 1.4578 15.5814
NCI-H2227 GDSC1; GDSC2 3.1383 14.4182 -2.38 29.4935
Lu-134-A GDSC1; GDSC2 3.2463 5.4642 2.1871 7.4078
HCC15 GDSC1; GDSC2 3.2699 4.9485 2.4649 5.5791
NCI-H2804 GDSC1; GDSC2 3.2855 4.9353 2.4847 5.408
NCI-H446 GDSC1; GDSC2 3.3025 6.4803 1.7265 10.1429
HOP-62 GDSC1; GDSC2 3.3976 9.8537 0.1189 19.1091
NCI-H290 GDSC1; GDSC2 3.4152 6.6129 1.7535 9.6484
NCI-H838 GDSC1; GDSC2 3.4159 5.1869 2.4665 5.1489
EMC-BAC-2 GDSC1; GDSC2 3.4208 9.5559 0.2869 18.1783
NCI-H596 GDSC1; GDSC2 3.4738 5.5112 2.3511 5.7191
LCLC-97TM1 GDSC1; GDSC2 3.4825 7.0104 1.6098 10.353
COR-L279 GDSC1; GDSC2 3.4861 5.6455 2.2939 6.0465
RERF-LC-MS GDSC1; GDSC2 3.5009 7.2635 1.4982 10.9909
NCI-H1666 GDSC1; GDSC2 3.5117 8.5687 0.8549 14.7982
LXF 289 GDSC1; GDSC2 3.5342 8.113 1.1009 13.2993
NCI-H1963 GDSC2 3.5554 6.3375 2.004 7.6859
NCI-H810 GDSC1; GDSC2 3.5625 10.4224 -0.0298 19.3625
SBC-5 GDSC1; GDSC2 3.5777 11.8483 -0.73 22.5003
VMRC-LCD GDSC1; GDSC2 3.5829 8.0646 1.1644 12.7843
IA-LM GDSC1; GDSC2 3.5833 9.705 0.3455 17.3959
Lu-139 GDSC1; GDSC2 3.5904 6.7402 1.8311 8.6756
NCI-H1341 GDSC1; GDSC2 3.5979 6.2218 2.095 6.9997
NCI-H720 GDSC1 3.6823 5.911 2.3141 6.732
NCI-H1563 GDSC1; GDSC2 3.7281 6.8652 1.8764 8.0273
COR-L32 GDSC1; GDSC2 3.7339 8.7725 0.9319 13.7287
NCI-H835 GDSC1 3.7388 7.1748 1.7309 11.0278
COR-L105 GDSC1; GDSC2 3.7604 10.4248 0.129 18.0069
NCI-H1437 GDSC1; GDSC2 3.7881 5.6688 2.5107 3.9291
NCI-H1693 GDSC1; GDSC2 3.8248 7.1891 1.7898 8.3171
Lu-99A GDSC1; GDSC2 3.8322 6.7023 2.0358 6.77
NCI-H2122 GDSC1; GDSC2 3.8433 5.3137 2.7198 2.5362
NCI-H526 GDSC1; GDSC2 3.8625 5.7907 2.5039 3.8029
NCI-H2347 GDSC1; GDSC2 3.8629 7.4909 1.6693 8.9641
Calu-3 GDSC1; GDSC2 3.8705 9.9897 0.4334 16.121
Ms-1 GDSC1; GDSC2 3.8726 6.4613 2.1842 5.7506
KNS-62 GDSC1; GDSC2 3.8899 9.9795 0.4539 15.9584
NCI-H524 GDSC1; GDSC2 3.8904 6.5265 2.1651 5.8259
NCI-H2030 GDSC1; GDSC2 3.9094 5.9382 2.4651 3.9358
NCI-H2171 GDSC2 3.9134 6.3597 2.2633 5.1654
NCI-H2810 GDSC1; GDSC2 3.9224 7.0957 1.9091 7.334
NCI-H1435 GDSC1; GDSC2 3.9314 6.1991 2.3542 4.5656
HARA [Human squamous cell lung carcinoma] GDSC1; GDSC2 3.9507 6.7367 2.1059 6.0493
HCC78 GDSC1; GDSC2 3.9569 11.8863 -0.4432 20.1853
LK-2 GDSC1; GDSC2 3.9812 7.2694 1.8671 7.4506
NCI-H2444 GDSC1; GDSC2 3.9889 5.9734 2.5024 3.5402
LC-1/sq GDSC1; GDSC2 3.9979 8.9799 1.0346 12.4243
NCI-H2373 GDSC1; GDSC2 4 8.3814 1.3327 10.6595
NCI-H1734 GDSC2 4.016 7.396 1.8304 7.5923
LOU-NH91 GDSC1; GDSC2 4.0282 9.7129 0.6943 14.2768
LC-2/ad GDSC1; GDSC2 4.0286 6.6044 2.2258 5.134
BEN GDSC1; GDSC2 4.0333 9.0217 1.0411 12.2948
NCI-H841 GDSC1 4.0369 7.1321 1.9748 8.262
SK-LU-1 GDSC1 4.0373 7.7433 1.6754 10.4936
Lu-135 GDSC1; GDSC2 4.0504 6.9804 2.0586 6.1087
NCI-H460 GDSC1; GDSC2 4.0543 6.659 2.2173 5.1285
NCI-H1694 GDSC1; GDSC2 4.0553 6.513 2.2885 4.6925
NCI-H1876 GDSC1; GDSC2 4.0616 6.3444 2.3738 4.1621
CPC-N GDSC1; GDSC2 4.086 9.6356 0.7771 13.6638
NCI-H1155 GDSC1; GDSC2 4.0922 6.5237 2.3086 4.4913
NCI-H2722 GDSC1; GDSC2 4.1011 8.0623 1.5656 9.0029
NCI-H1581 GDSC1; GDSC2 4.1055 6.0812 2.5279 3.1537
NCI-H2291 GDSC1; GDSC2 4.108 6.1671 2.489 3.378
LB647-SCLC GDSC1; GDSC2 4.1181 6.9443 2.1237 5.5578
SW1271 GDSC1; GDSC2 4.1184 7.6785 1.7665 7.7392
NCI-H1299 GDSC1; GDSC2 4.1189 8.8322 1.1995 11.1496
NCI-H345 GDSC1; GDSC2 4.1234 5.3916 2.854 1.2899
NCI-H209 GDSC1; GDSC2 4.1246 7.8301 1.6967 8.1495
NCI-H1436 GDSC1; GDSC2 4.1271 5.8405 2.6537 2.3834
NCI-H2803 GDSC1; GDSC2 4.1352 6.8016 2.2043 5.03
IST-SL2 GDSC1; GDSC2 4.1395 7.0207 2.1016 5.6451
NCI-H520 GDSC1; GDSC2 4.1416 8.0285 1.6119 8.6245
NCI-H2369 GDSC1; GDSC2 4.1421 8.6848 1.2895 10.5591
COR-L321 GDSC1; GDSC2 4.1557 6.8912 2.1753 5.1617
NCI-H740 GDSC2 4.1651 8.2425 1.524 9.0991
NCI-H1304 GDSC1 4.1742 8.6189 1.3458 12.4408
NCI-H146 GDSC1; GDSC2 4.1797 6.7796 2.2452 4.6888
PC-14 GDSC1; GDSC2 4.1989 7.2989 2.0084 6.0798
NCI-H1048 GDSC1; GDSC2 4.2009 6.3161 2.4786 3.2592
NCI-H2087 GDSC1; GDSC2 4.2045 6.8679 2.2196 4.7903
HCC33 GDSC2 4.2286 6.676 2.327 4.0992
NCI-H196 GDSC1; GDSC2 4.2508 6.2177 2.5555 2.7243
HCC366 GDSC1; GDSC2 4.265 9.4286 1.0145 11.8598
NCI-H1648 GDSC1; GDSC2 4.2783 7.5958 1.92 6.44
NCI-H1770 GDSC1; GDSC2 4.2802 6.3247 2.5241 2.8507
NCI-H2595 GDSC1; GDSC2 4.2819 12.0626 -0.2765 18.5519
IST-SL1 GDSC1; GDSC2 4.2941 8.5202 1.4817 9.0451
NCI-H23 GDSC1; GDSC2 4.3041 10.3043 0.6116 14.0146
NCI-H1944 GDSC1; GDSC2 4.308 12.7139 -0.5797 19.8483
EMC-BAC-1 GDSC1; GDSC2 4.3141 7.3205 2.0768 5.418
NCI-H1869 GDSC1 4.3213 10.9343 0.3131 18.5016
SHP-77 GDSC1; GDSC2 4.3358 6.6647 2.401 3.4581
COR-L23 GDSC1; GDSC2 4.3439 9.8276 0.8766 12.4482
NCI-H1792 GDSC1; GDSC2 4.3542 9.6051 0.9936 11.7593
NCI-H358 GDSC1; GDSC2 4.3757 7.1637 2.1923 4.604
NCI-H2591 GDSC1; GDSC2 4.3835 16.1149 -2.2128 25.6802
NCI-H2461 GDSC1; GDSC2 4.3857 9.4495 1.0931 11.1113
NCI-H1703 GDSC1; GDSC2 4.3938 6.7417 2.4013 3.3501
NCI-H1836 GDSC1; GDSC2 4.3986 6.1482 2.6731 1.8386
NCI-H226 GDSC1; GDSC2 4.4251 12.271 -0.2698 18.1493
NCI-H1105 GDSC1; GDSC2 4.4829 7.9306 1.8986 6.1297
RERF-LC-Sq1 GDSC1; GDSC2 4.4905 8.9308 1.4216 8.9477
NCI-H2342 GDSC1; GDSC2 4.4943 7.1674 2.2663 3.9442
NCI-H2731 GDSC1; GDSC2 4.5359 11.2778 0.3048 15.0551
NCI-H1993 GDSC1; GDSC2 4.5408 12.4591 -0.2749 17.8777
NCI-H2170 GDSC1; GDSC2 4.5856 6.6134 2.5718 2.0984
NCI-H3255 GDSC1; GDSC2 4.5986 7.0602 2.3791 3.1203
SK-MES-1 GDSC1; GDSC2 4.6036 11.5093 0.2411 15.2129
NCI-H2085 GDSC1; GDSC2 4.6191 7.5397 2.1711 4.2633
NCI-H441 GDSC1; GDSC2 4.6237 7.5365 2.1755 4.2294
NCI-H2818 GDSC1; GDSC2 4.628 12.8963 -0.4252 18.3443
ABC-1 GDSC1; GDSC2 4.628 7.0995 2.3786 3.0745
NCI-H2081 GDSC1; GDSC2 4.6515 9.9956 1.0178 10.9134
COR-L88 GDSC1; GDSC2 4.6597 6.9377 2.4697 2.5289
NCI-H1568 GDSC1; GDSC2 4.6626 12.1955 -0.0531 16.5246
NCI-H727 GDSC1; GDSC2 4.6768 12.0267 0.0406 16.034
NCI-H522 GDSC1; GDSC2 4.686 12.3931 -0.1331 16.8497
COR-L303 GDSC2 4.7079 7.1381 2.4076 2.7883
NCI-H1355 GDSC1; GDSC2 4.7194 9.7245 1.1972 9.7366
HOP-92 GDSC1; GDSC2 4.733 14.4171 -1.098 20.9141
EKVX GDSC1; GDSC2 4.7372 7.9244 2.066 4.6503
DMS 114 GDSC1; GDSC2 4.7823 13.321 -0.5189 18.3791
CAL-12T GDSC1; GDSC2 4.7874 10.2999 0.966 10.8936
NCI-H1755 GDSC1; GDSC2 4.7901 9.3878 1.4081 8.3664
Lu-65 GDSC1; GDSC2 4.7931 7.0187 2.5077 2.1373
HCC827 GDSC1; GDSC2 4.7966 9.344 1.4335 8.2053
DMS 79 GDSC1; GDSC2 4.8269 7.0221 2.5243 2.0079
NCI-H1781 GDSC1; GDSC2 4.8287 7.4377 2.3427 2.9513
NCI-H1651 GDSC1; GDSC2 4.8443 10.224 1.0425 10.3366
NCI-H250 GDSC2 4.8661 7.1154 2.5049 2.0533
NCI-H64 GDSC2 4.8668 9.0737 1.6092 7.0423
NCI-H2110 GDSC1; GDSC2 4.8754 7.6731 2.264 3.3039
NCI-H1650 GDSC1; GDSC2 4.887 9.6509 1.3475 8.5096
NCI-H2066 GDSC1; GDSC2 4.91 11.9713 0.2387 14.4869
NCI-H2135 GDSC1; GDSC2 4.9132 6.5199 2.7747 0.7889
COLO 668 GDSC1; GDSC2 4.9254 8.7087 1.8188 5.7196
NCI-H187 GDSC1 4.9446 6.4773 2.8052 0.8124
DMS 273 GDSC1; GDSC2 4.9506 9.8613 1.2898 8.7057
NCI-H1793 GDSC1; GDSC2 4.981 12.8753 -0.1525 16.2278
NCI-H2405 GDSC1; GDSC2 5.0078 9.9284 1.2961 8.5504
ChaGo-K-1 GDSC1; GDSC2 5.0439 8.0824 2.1774 3.5079
NCI-H1092 GDSC1; GDSC2 5.0722 6.854 2.7143 0.8897
COR-L311 GDSC2 5.1174 6.8626 2.731 0.7907
NCI-H1688 GDSC1; GDSC2 5.1428 6.9926 2.6913 0.9197
NCI-H3122 GDSC2 5.1508 11.5258 0.6261 11.9319
NCI-H661 GDSC1; GDSC2 5.1589 11.3984 0.6931 11.5579
NCI-H69 GDSC1; GDSC2 5.1956 13.57 -0.3369 16.5784
NCI-H1623 GDSC1; GDSC2 5.2254 7.6866 2.4476 1.8868
Lu-165 GDSC1; GDSC2 5.2517 10.9918 0.9515 9.9631
COR-L95 GDSC1; GDSC2 5.2553 8.6919 2.0256 3.9954
LCLC-103H GDSC1; GDSC2 5.256 14.3542 -0.6771 17.9376
NCI-H2009 GDSC1; GDSC2 5.2754 11.6979 0.629 11.6449
PaCa-3 GDSC1; GDSC2 5.2795 10.6859 1.1157 9.0037
NCI-H2029 GDSC1; GDSC2 5.2862 6.9667 2.763 0.5669
NCI-H513 GDSC1; GDSC2 5.357 12.5669 0.2659 13.3329
NCI-H2023 GDSC1; GDSC2 5.3571 14.7719 -0.8082 18.2574
NCI-H82 GDSC1; GDSC2 5.386 11.8327 0.6396 11.353
NCI-H322M GDSC1; GDSC2 5.3939 9.9554 1.5318 6.4742
Calu-6 GDSC1; GDSC2 5.3957 13.9483 -0.3778 16.3064
NCI-H510A GDSC2 5.4647 6.9886 2.8256 0.3098
NCI-H1915 GDSC1; GDSC2 5.5026 11.1611 1.0366 8.9916
NCI-H2196 GDSC2 5.5199 7.0998 2.8068 0.3316
NCI-H2141 GDSC1; GDSC2 5.5234 7.0723 2.8179 0.3048
NCI-H2172 GDSC1; GDSC2 5.5342 7.3007 2.7394 0.4992
DMS 53 GDSC1; GDSC2 5.6197 7.2213 2.8012 0.3063
NCI-H650 GDSC1; GDSC2 5.6247 15.4838 -0.963 18.2893
NCI-H2869 GDSC1; GDSC2 5.6349 10.3029 1.5189 6.1202
NCI-H1975 GDSC1; GDSC2 5.6503 14.1781 -0.3095 15.434
NCI-H2228 GDSC1; GDSC2 5.6831 9.669 1.8331 4.3606
NCI-H748 GDSC2 5.6917 8.278 2.4299 1.4805
NCI-H1573 GDSC1; GDSC2 5.9003 19.2408 -2.6042 23.3901
A-427 GDSC1; GDSC2 6.2677 17.1646 -1.3246 18.3249
NCI-H647 GDSC2 6.3107 8.2808 2.6846 0.3154
SW1573 GDSC1; GDSC2 6.7148 17.9708 -1.404 17.7215
NCI-H1838 GDSC1; GDSC2 6.7463 17.178 -1.0019 16.1175
⏷ Show the Full List of 186 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1; GDSC2 3.4453 7.2403 1.4646 11.3558
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OE21 GDSC1; GDSC2 3.2155 9.2998 0.2439 19.021
KYSE-270 GDSC1; GDSC2 3.2677 7.4666 1.2042 13.4594
TE-6 GDSC1; GDSC2 3.6294 5.9557 2.2517 5.9328
KYSE-520 GDSC1; GDSC2 3.6883 6.3929 2.08 6.8573
TE-5 GDSC1; GDSC2 3.8387 9.4681 0.6681 14.9327
KYSE-510 GDSC1; GDSC2 3.8727 5.5151 2.6434 2.9339
KYSE-70 GDSC1; GDSC2 3.9225 11.2031 -0.13 18.8279
KYSE-410 GDSC1; GDSC2 3.9346 9.5633 0.696 14.5177
KYSE-140 GDSC1; GDSC2 4.0527 8.2386 1.4429 9.8642
TE-11 GDSC1; GDSC2 4.3016 7.7025 1.8846 6.6029
TE-10 GDSC1; GDSC2 4.3163 9.8244 0.8576 12.6237
TE-4 GDSC1; GDSC2 4.3529 6.835 2.3323 3.8254
TE-8 GDSC1; GDSC2 4.3725 8.5699 1.5135 8.6727
COLO 680N GDSC1; GDSC2 4.4194 7.1414 2.231 4.2903
KYSE-450 GDSC1; GDSC2 4.4668 9.6985 1.0301 11.2779
TE-9 GDSC1; GDSC2 4.4703 7.8982 1.9056 6.1142
OE33 GDSC1; GDSC2 4.6481 8.1847 1.887 5.8611
T.T GDSC1; GDSC2 4.745 8.8532 1.6334 7.1499
OE19 GDSC1; GDSC2 4.7726 10.9769 0.6257 12.7943
KYSE-180 GDSC1; GDSC2 5.0808 11.1484 0.7599 11.3708
KYSE-150 GDSC1; GDSC2 5.1021 11.0837 0.8058 11.0757
EC-GI-10 GDSC1; GDSC2 5.1413 11.3686 0.6953 11.5847
TE-1 GDSC1; GDSC2 5.5181 10.971 1.1361 8.4206
TE-15 GDSC1; GDSC2 5.676 8.2629 2.4287 1.5
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TYK-nu GDSC1; GDSC2 2.4671 6.5934 0.9288 17.6885
FU-OV-1 GDSC1; GDSC2 2.6488 6.0603 1.3581 14.501
OC 314 GDSC1; GDSC2 2.9753 8.1558 0.6104 17.8065
Caov-3 GDSC2 2.9791 4.8676 2.2476 7.8687
RMG-I GDSC1; GDSC2 3.3465 10.6702 -0.3318 21.432
OVTOKO GDSC1; GDSC2 3.4064 12.6889 -1.2914 25.2073
OVK18 GDSC1; GDSC2 3.6349 5.6129 2.4257 4.827
JHOS-2 GDSC1; GDSC2 3.7428 6.5844 2.0268 7.0509
JHOS-4 GDSC2 3.7642 6.693 1.9893 7.2305
IGROV-1 GDSC1; GDSC2 3.8433 5.7111 2.529 3.6922
TOV-112D GDSC1; GDSC2 3.8704 8.3228 1.2626 11.4158
TOV-21G GDSC1; GDSC2 3.9341 15.121 -2.0755 26.4061
OVCAR-3 GDSC1; GDSC2 4.0413 7.4836 1.8059 7.6819
OV56 GDSC1; GDSC2 4.0748 6.9777 2.0771 5.9394
OV-90 GDSC1; GDSC2 4.0768 7.807 1.6732 8.4078
Caov-4 GDSC1; GDSC2 4.0911 9.0719 1.0601 12.0355
OVCAR-8 GDSC1; GDSC2 4.1377 9.8789 0.696 13.98
Kuramochi GDSC1; GDSC2 4.1458 11.96 -0.3312 19.1648
OVCAR-5 GDSC1; GDSC2 4.2187 14.3193 -1.4484 23.544
OAW28 GDSC1; GDSC2 4.2218 10.1289 0.6362 14.0914
A2780 GDSC1; GDSC2 4.4713 7.76 1.9722 5.716
OVKATE GDSC1; GDSC2 4.4871 10.946 0.432 14.5147
DOV13 GDSC1; GDSC2 4.632 13.0253 -0.4859 18.6056
ES-2 GDSC1; GDSC2 4.6538 11.7622 0.1538 15.5299
EFO-21 GDSC1; GDSC2 4.7292 13.2026 -0.5002 18.4276
OVCAR-4 GDSC1; GDSC2 4.7934 10.6395 0.8052 11.7713
EFO-27 GDSC1; GDSC2 5.091 10.1255 1.2575 8.5968
SK-OV-3 GDSC1; GDSC2 5.6228 14.2304 -0.3541 15.6954
OAW42 GDSC1; GDSC2 6.3853 14.755 -0.0875 12.9059
OVISE GDSC1; GDSC2 6.9731 19.3618 -1.8968 18.9711
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuP-T4 GDSC1; GDSC2 3.0799 8.1502 0.7032 16.9574
PaTu 8988t GDSC1; GDSC2 3.1497 6.2362 1.7189 10.6483
HuP-T3 GDSC1; GDSC2 3.2153 6.1878 1.7992 9.9459
Panc 02.03 GDSC1; GDSC2 3.4706 7.9325 1.1393 13.2531
HPAF-II GDSC1 3.5245 7.2884 1.5049 13.4357
Panc 08.13 GDSC1; GDSC2 3.5261 7.4874 1.4068 11.481
SUIT-2 GDSC1; GDSC2 3.7095 6.8561 1.8666 8.137
Panc 10.05 GDSC1; GDSC2 3.7584 7.2219 1.7227 8.9042
PL4 GDSC1; GDSC2 3.8488 7.8682 1.4716 10.2108
QGP-1 GDSC1; GDSC2 3.9027 6.3286 2.2708 5.1438
Hs 766T GDSC1; GDSC2 3.9201 5.8926 2.4945 3.7337
MZ-PC-1 GDSC1; GDSC2 3.9235 6.5879 2.1591 5.7851
KP-4 GDSC1; GDSC2 3.9416 10.0682 0.4503 15.8367
MIA PaCa-2 GDSC2 3.9908 6.5213 2.2396 5.1344
PaTu 8902 GDSC1; GDSC2 4.0176 6.3828 2.3253 4.5506
SU.86.86 GDSC1; GDSC2 4.0191 6.1502 2.4381 3.864
PSN1 GDSC1; GDSC2 4.1323 7.4058 1.9096 6.8322
BxPC-3 GDSC1; GDSC2 4.2337 12.7009 -0.6311 20.2667
Panc 04.03 GDSC1; GDSC2 4.4295 9.0342 1.328 9.6391
HPAC GDSC1; GDSC2 4.5416 7.8254 1.9875 5.4828
DAN-G GDSC1; GDSC2 4.5587 8.1638 1.838 6.332
Capan-1 GDSC1; GDSC2 4.5779 14.0312 -1.0254 21.014
YAPC GDSC1; GDSC2 4.6508 7.6039 2.1611 4.2629
Panc 03.27 GDSC1; GDSC2 4.6709 9.0672 1.481 8.1984
KP-1N GDSC1; GDSC2 4.6736 10.5596 0.7584 12.3071
KP-2 GDSC1; GDSC2 4.8279 9.1778 1.534 7.5575
CFPAC-1 GDSC1; GDSC2 4.9227 12.6237 -0.0717 15.9825
KP-3 GDSC1; GDSC2 5.1644 14.024 -0.582 17.741
AsPC-1 GDSC1; GDSC2 5.1715 10.1456 1.301 8.1885
SW1990 GDSC1; GDSC2 5.3458 11.8109 0.6227 11.5266
Capan-2 GDSC1; GDSC2 6.221 15.5348 -0.57 15.3812
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IST-Mes1 GDSC1; GDSC2 2.9656 7.7693 0.7948 16.7986
MPP 89 GDSC1; GDSC2 3.8372 6.6644 2.0583 6.6177
NCI-H2452 GDSC1; GDSC2 4 7.915 1.5631 9.2679
MSTO-211H GDSC1; GDSC2 4.2621 7.5561 1.9279 6.428
NCI-H2052 GDSC2 4.5786 7.1282 2.3361 3.395
NCI-H28 GDSC1; GDSC2 6.6204 15.871 -0.4625 14.1246
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
VCaP GDSC1; GDSC2 3.2146 7.4523 1.1666 13.845
PC-3 GDSC1; GDSC2 3.6676 9.5142 0.509 16.2816
LNCaP clone FGC GDSC1; GDSC2 3.6741 10.9871 -0.2213 19.9587
DU145 GDSC1; GDSC2 4.591 9.0191 1.4491 8.5603
22Rv1 GDSC1; GDSC2 5.0113 15.7242 -1.5337 21.8799
NCI-H660 GDSC2 5.3234 6.6539 2.8912 0.2189
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1; GDSC2 4.9159 8.2059 2.0458 4.4458
Cancer Drug Sensitivity Data Curated from 57 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LOX-IMVI GDSC1; GDSC2 2.8199 4.7934 2.135 9.1138
SK-MEL-28 GDSC1; GDSC2 2.8236 5.8187 1.6373 12.196
CHL-1 GDSC1; GDSC2 2.8725 8.4665 0.3661 19.4624
IGR-37 GDSC1; GDSC2 2.9313 12.2689 -1.4811 27.3037
A2058 GDSC1; GDSC2 2.9614 8.1116 0.6204 17.795
A101D GDSC1; GDSC2 3.0843 10.4597 -0.4469 22.7539
DJM-1 GDSC2 3.178 6.0493 1.8366 9.8242
SK-MEL-2 GDSC1 3.1811 6.9638 1.3824 15.5913
IPC-298 GDSC1; GDSC2 3.2222 8.0667 0.866 15.5913
SH-4 GDSC1; GDSC2 3.4644 6.6985 1.7509 9.5254
WM35 GDSC1; GDSC2 3.4767 8.3274 0.947 14.3678
M14 GDSC1 3.5091 6.6139 1.8292 11.0584
COLO 800 GDSC1; GDSC2 3.524 5.615 2.3391 5.6591
G-361 GDSC1; GDSC2 3.5275 9.353 0.476 16.8623
Mel Ho GDSC1; GDSC2 3.5428 5.1785 2.5707 4.1519
A-375 GDSC1; GDSC2 3.5742 8.3207 1.0295 13.6067
MMAc-SF GDSC1; GDSC2 3.5753 6.0007 2.1874 6.4784
COLO 679 GDSC1; GDSC2 3.5769 7.3951 1.4937 10.8065
MZ-MEL-7 GDSC1; GDSC2 3.6232 6.3628 2.0446 7.2494
COLO 792 GDSC1; GDSC2 3.6765 11.978 -0.7143 22.1507
SK-MEL-30 GDSC1; GDSC2 3.7007 6.7117 1.9314 7.7551
HMV-II GDSC1; GDSC2 3.7045 10.4827 0.0552 18.5346
MZ-MEL-2 GDSC1; GDSC2 3.7557 9.1205 0.7757 14.5597
Hs 940.T GDSC1; GDSC2 3.7977 6.7157 2.0034 7.0575
WM1552C GDSC1; GDSC2 3.8052 7.623 1.5597 9.7865
451Lu GDSC1; GDSC2 3.8059 6.253 2.2376 5.5793
CP66-MEL GDSC1; GDSC2 3.8085 6.4991 2.1184 6.3148
SK-MEL-5 GDSC1; GDSC2 3.8089 6.1807 2.2753 5.3375
A-388 GDSC1; GDSC2 3.8389 6.0667 2.3529 4.7856
CP50-MEL-B GDSC1; GDSC2 3.867 6.4345 2.1932 5.7079
COLO 783 GDSC1; GDSC2 3.8817 5.5697 2.6234 3.0359
WM115 GDSC1; GDSC2 3.9195 6.9266 1.9901 6.8399
LB373-MEL-D GDSC1; GDSC2 3.9459 9.102 0.934 13.1425
G-mel GDSC1; GDSC2 3.977 7.6694 1.6671 8.6901
VMRC-MELG GDSC1; GDSC2 4.0079 6.1175 2.4462 3.8388
Hs 938.T GDSC1; GDSC2 4.0596 6.1355 2.4722 3.5754
SK-MEL-31 GDSC1; GDSC2 4.1008 8.3625 1.4176 9.8967
A-431 GDSC1; GDSC2 4.1104 6.8873 2.1459 5.4393
SK-MEL-3 GDSC1; GDSC2 4.1242 6.4288 2.3755 4.0219
LB2518-MEL GDSC1; GDSC2 4.1665 6.2537 2.486 3.2821
WT2-iPS GDSC1; GDSC2 4.3185 9.0377 1.246 10.3838
RPMI-7951 GDSC1; GDSC2 4.4582 15.9194 -2.0567 25.0036
Mel JuSo GDSC1; GDSC2 4.4679 8.0155 1.8479 6.4635
MeWo GDSC1; GDSC2 4.504 9.8098 1.0026 11.3459
WM278 GDSC1; GDSC2 4.5111 10.6639 0.5887 13.6212
RVH-421 GDSC1; GDSC2 4.5893 8.983 1.4654 8.4684
IGR-1 GDSC1; GDSC2 4.7976 13.965 -0.8254 19.6542
SK-MEL-1 GDSC1; GDSC2 4.8804 12.0469 0.1802 14.8503
UACC-62 GDSC1; GDSC2 4.9164 18.2984 -2.8825 26.3505
SK-MEL-24 GDSC1; GDSC2 5.0169 13.3865 -0.3772 17.1799
UACC-257 GDSC1; GDSC2 5.1696 11.0878 0.85 10.6896
GAK GDSC1; GDSC2 5.2027 13.3752 -0.2365 16.102
WM793 GDSC1; GDSC2 5.4887 15.2845 -0.9637 18.5961
IST-MEL1 GDSC1; GDSC2 5.7433 10.8035 1.3548 6.8197
HT-144 GDSC1; GDSC2 6.8977 21.0993 -2.7918 21.9391
COLO 829 GDSC1; GDSC2 7.6399 18.0771 -0.8425 13.8378
EquiPSC Line K2 GDSC1; GDSC2 3.7151 6.6512 1.9726 7.4607
⏷ Show the Full List of 57 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1; GDSC2 3.8796 6.2808 2.2776 5.156
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW982 GDSC1; GDSC2 2.7936 7.9272 0.5654 18.6427
Rh41 GDSC1; GDSC2 2.8677 7.011 1.0864 15.4107
SW872 GDSC1; GDSC2 2.9941 7.7466 0.8308 16.5015
G-402 GDSC1; GDSC2 3.0584 8.1578 0.681 17.1492
A-204 GDSC1; GDSC2 3.1777 10.6711 -0.4735 22.5833
GCT GDSC1; GDSC2 3.2691 11.0917 -0.6071 22.8887
G-401 GDSC1; GDSC2 3.2922 6.1963 1.8599 9.3365
Rh18 GDSC1 3.5162 9.9255 0.1806 21.9462
SK-LMS-1 GDSC1; GDSC2 3.5557 6.8186 1.7644 9.1871
KYM-1 GDSC1; GDSC2 3.6909 6.6165 1.9711 7.5322
MES-SA GDSC1; GDSC2 3.6987 8.7658 0.9072 13.9682
STS-0421 GDSC1; GDSC2 3.8107 7.8949 1.4289 10.5702
SW684 GDSC1; GDSC2 3.8361 7.4092 1.6893 8.9091
HT-1080 GDSC1; GDSC2 3.8848 9.437 0.7199 14.5188
EW-8 GDSC1; GDSC2 3.9271 6.5967 2.1574 5.787
TE 441.T GDSC2 3.9923 5.6961 2.6362 2.7356
Rh30 GDSC1; GDSC2 4.0782 6.2342 2.4376 3.7445
VA-ES-BJ GDSC1; GDSC2 4.3826 16.1185 -2.2153 25.6901
Hs 633.T GDSC1; GDSC2 4.4577 13.4194 -0.8143 20.4602
RKN GDSC1; GDSC2 4.7056 9.2581 1.4128 8.5208
MFH-ino GDSC1; GDSC2 4.8047 10.1867 1.033 10.4786
RD GDSC1; GDSC2 4.8146 12.7814 -0.2288 16.9847
SK-UT-1 GDSC1; GDSC2 6.183 16.1765 -0.9054 16.86
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NUGC-4 GDSC1; GDSC2 2.4992 8.1611 0.1866 21.6463
MKN28 GDSC1; GDSC2 2.8566 7.4541 0.8563 16.7961
ECC10 GDSC1; GDSC2 2.8718 5.5541 1.8117 10.9516
HGC-27 GDSC1; GDSC2 2.9327 5.825 1.7328 11.2439
SNU-16 GDSC1; GDSC2 3.0989 4.9172 2.3316 6.9506
Fu97 GDSC1; GDSC2 3.1906 8.1356 0.8048 16.0393
HSC-39 GDSC1; GDSC2 3.4118 5.6768 2.2185 6.7287
MKN1 GDSC1 3.4795 6.5379 1.8433 11.0538
AGS GDSC1; GDSC2 3.6958 8.2468 1.1637 12.4751
RERF-GC-1B GDSC1; GDSC2 3.8601 7.1777 1.8222 8.0269
NUGC-3 GDSC1; GDSC2 3.9063 6.8512 2.0174 6.7027
MKN45 GDSC1; GDSC2 3.9452 7.8534 1.5523 9.4713
IM95 GDSC1; GDSC2 4.0387 6.083 2.4833 3.5514
TGBC11TKB GDSC1; GDSC2 4.0568 6.3261 2.3793 4.1392
SK-GT-2 GDSC1; GDSC2 4.1159 10.3998 0.421 15.5255
TMK-1 GDSC1; GDSC2 4.1566 7.8318 1.7191 7.9376
KATO III GDSC1; GDSC2 4.1832 6.0762 2.5792 2.7091
NCI-N87 GDSC1; GDSC2 4.2114 8.6485 1.3587 9.9773
OCUM-1 GDSC2 4.2206 6.4946 2.4074 3.6392
SNU-1 GDSC1; GDSC2 4.2794 6.942 2.2342 4.5488
23132/87 GDSC1; GDSC2 4.3059 8.7053 1.3997 9.5061
SNU-5 GDSC1; GDSC2 4.3811 6.1815 2.6485 1.995
SCH GDSC1; GDSC2 4.4136 6.2627 2.6308 2.0403
MKN7 GDSC1; GDSC2 4.4361 6.7106 2.4415 3.0465
Hs 746.T GDSC1; GDSC2 4.6119 12.1755 -0.0812 16.7858
RF-48 GDSC1; GDSC2 4.7555 6.9943 2.498 2.2397
ECC12 GDSC2 4.9093 6.2608 2.8727 0.4506
GCIY GDSC2 5.5032 12.7477 0.2797 12.9465
SNG-M GDSC1; GDSC2 3.8081 9.7147 0.5211 15.8221
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BHT-101 GDSC1; GDSC2 2.2955 6.8868 0.6254 20.0226
CAL-62 GDSC1; GDSC2 2.5867 7.5187 0.5833 19.2368
HTC-C3 GDSC1; GDSC2 3.1462 7.5904 1.0396 14.8099
K5 GDSC1; GDSC2 3.3058 6.1774 1.8807 9.1657
IHH-4 GDSC1; GDSC2 3.4068 7.7217 1.1924 13.1209
KMH-2 GDSC1; GDSC2 3.5007 7.15 1.5547 10.6432
B-CPAP GDSC1; GDSC2 3.7693 7.6425 1.5222 10.1111
CGTH-W-1 GDSC1; GDSC2 3.8195 13.2861 -1.2518 23.8903
8505C GDSC1; GDSC2 3.9528 9.7376 0.6235 14.8686
ASH-3 GDSC1; GDSC2 4.019 9.9628 0.5631 15.021
8305C GDSC1; GDSC2 4.0367 8.8644 1.1215 11.8173
TT2609-C02 GDSC1; GDSC2 4.094 8.0373 1.5727 8.9773
TT GDSC1; GDSC2 4.5435 10.7167 0.5866 13.5531
FTC-133 GDSC1; GDSC2 4.5725 8.8979 1.4949 8.3319
WRO GDSC1; GDSC2 4.6741 9.2769 1.3821 8.7686
ML-1 [Human leukemia] GDSC1; GDSC2 4.814 8.0264 2.0663 4.5097
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 41 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PCI-38 GDSC1 2.0085 5.7799 0.8795 24.182
HSC-3 GDSC1; GDSC2 2.1469 11.7173 -1.8912 31.1349
BB49-HNC GDSC1 2.2656 5.2779 1.3673 19.6146
HO-1-N-1 GDSC1; GDSC2 3.0109 8.0579 0.69 17.2488
LB771-HNC GDSC1; GDSC2 3.0573 6.6381 1.4385 12.675
NCI-H3118 GDSC1; GDSC2 3.1413 6.0773 1.791 10.2225
CAL-27 GDSC1; GDSC2 3.1845 8.3942 0.6704 16.8175
SAS GDSC1; GDSC2 3.227 8.3239 0.7414 16.2886
PCI-04B GDSC1; GDSC2 3.2677 6.6416 1.6167 10.9313
KOSC-2 GDSC1; GDSC2 3.2775 5.765 2.0632 8.0977
SKN-3 GDSC1; GDSC2 3.3725 7.326 1.3619 12.1948
DOK GDSC1; GDSC2 3.3745 9.1685 0.4423 17.4936
BICR 78 GDSC1; GDSC2 3.402 8.6558 0.7214 15.8773
BICR 10 GDSC1 3.4054 7.8567 1.1237 16.5723
Detroit 562 GDSC1; GDSC2 3.4337 9.4724 0.3394 17.8651
Ca9-22 GDSC1; GDSC2 3.4459 8.101 1.0349 13.9427
KON GDSC1; GDSC2 3.4517 5.2436 2.467 5.0476
HSC-2 GDSC1; GDSC2 3.4995 9.2016 0.5287 16.6579
FaDu GDSC1; GDSC2 3.4997 6.3742 1.9413 8.2328
CAL-33 GDSC1; GDSC2 3.5756 5.2221 2.5741 4.0466
OSC-19 GDSC1; GDSC2 3.673 6.7109 1.9104 7.9592
JHU-029 GDSC1; GDSC2 3.7527 6.6653 1.9943 7.2283
JHU-022 GDSC1; GDSC2 3.7899 8.4009 1.1611 12.2345
BB30-HNC GDSC2 3.8497 7.1319 1.8369 7.9618
PCI-06A GDSC1; GDSC2 3.9126 6.819 2.0379 6.5604
BHY GDSC1; GDSC2 3.9128 5.8227 2.5231 3.576
SAT [Human HNSCC] GDSC2 3.9167 11.5627 -0.3139 19.708
HO-1-u-1 GDSC1; GDSC2 3.9868 9.5367 0.7497 14.0784
BICR 31 GDSC2 4.0045 7.0642 1.9847 6.6702
PE/CA-PJ15 GDSC1; GDSC2 4.1418 8.252 1.5023 9.2864
JHU-011 GDSC1; GDSC2 4.1658 9.1297 1.0878 11.6846
SCC-9 GDSC1; GDSC2 4.2432 8.9478 1.235 10.6313
UPCI-SCC-090 GDSC1; GDSC2 4.3287 11.1529 0.2105 16.0621
HSC-4 GDSC1; GDSC2 4.4218 11.7632 -0.0208 16.9735
PCI-15A GDSC1; GDSC2 4.6228 10.016 0.9874 11.1521
BICR 22 GDSC1; GDSC2 4.8078 13.9621 -0.8163 19.591
SCC-15 GDSC1; GDSC2 4.9284 16.1082 -1.7867 22.9652
SCC-25 GDSC1; GDSC2 5.1378 7.6487 2.4188 2.1298
SCC-4 GDSC1; GDSC2 5.3738 14.1843 -0.5087 16.9382
PCI-30 GDSC1; GDSC2 5.799 16.0252 -1.1023 18.4616
OSC-20 GDSC1; GDSC2 6.6088 18.3277 -1.6497 18.8233
⏷ Show the Full List of 41 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BFTC-905 GDSC1; GDSC2 2.0548 7.9694 -0.127 24.7764
KU-19-19 GDSC1; GDSC2 2.0743 5.9512 0.8635 19.4913
639V GDSC1; GDSC2 3.5603 8.6073 0.8751 14.5428
HT-1197 GDSC1; GDSC2 3.5869 8.4054 0.9975 13.7585
CAL-29 GDSC1; GDSC2 3.6231 10.019 0.221 17.929
T24 GDSC1; GDSC2 3.6606 5.6358 2.4337 4.7128
SW1710 GDSC1; GDSC2 3.8551 13.1856 -1.173 23.4938
RT-4 GDSC1; GDSC2 3.9433 7.555 1.6983 8.5824
5637 GDSC1; GDSC2 3.9753 9.1811 0.9174 13.16
SW780 GDSC1; GDSC2 3.9807 10.4168 0.3074 16.4836
HT-1376 GDSC1; GDSC2 4.0956 7.1312 2.0172 6.2584
TCCSUP GDSC1; GDSC2 4.4272 12.6899 -0.4758 19.0808
UM-UC-3 GDSC1; GDSC2 4.5906 8.7003 1.6025 7.6577
RT-112 GDSC1; GDSC2 5.1785 13.7122 -0.4189 16.9884
J82 GDSC1; GDSC2 6.0717 17.9843 -1.8631 20.667
647V GDSC1; GDSC2 6.3434 14.9867 -0.2253 13.6162
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TC-YIK GDSC1 0.6275 3.6296 0.292 35.5579
BPH-1 GDSC1; GDSC2 1.9666 7.7296 -0.0929 24.9434
KGN GDSC1; GDSC2 2.0506 7.6944 0.0031 24.1676
NT2-D1 GDSC1; GDSC2 2.52 5.9438 1.2946 15.3313
NCC-IT GDSC2 2.6936 10.4121 -0.7595 25.3399
OV17R GDSC1; GDSC2 2.9567 6.7744 1.2826 13.945
OVCA420 GDSC1; GDSC2 3.0392 7.6355 0.9252 15.8129
SKN GDSC1; GDSC2 3.1337 9.3345 0.1574 19.7173
SiHa GDSC1; GDSC2 3.1916 9.8975 -0.0751 20.693
HEY GDSC1; GDSC2 3.2417 11.9301 -1.0492 24.7783
NEC8 GDSC1; GDSC2 3.3556 7.2142 1.4038 11.9876
MS751 GDSC1; GDSC2 3.4063 7.663 1.2212 12.949
OVMIU GDSC1; GDSC2 3.4416 12.8515 -1.3435 25.2957
Ca Ski GDSC1; GDSC2 3.4442 8.3437 0.9122 14.6638
SW962 GDSC1; GDSC2 3.6469 6.31 2.0894 6.9063
ME-180 GDSC1; GDSC2 3.6485 9.8115 0.3451 17.2107
CAL-39 GDSC1; GDSC2 3.6941 8.0418 1.2645 11.8774
LB831-BLC GDSC1; GDSC2 3.7451 9.9522 0.3525 16.8978
OMC-1 [Human cervical carcinoma] GDSC1; GDSC2 3.8015 5.7689 2.4714 4.1404
PA-1 GDSC2 3.8271 8.5849 1.0987 12.5026
SW756 GDSC1; GDSC2 3.9484 6.7874 2.0795 6.2179
C-33 A GDSC1; GDSC2 4.0386 8.3977 1.3538 10.4355
ACC-OV7 GDSC1; GDSC2 4.0603 7.2603 1.9291 6.8804
DoTc2 4510 GDSC1; GDSC2 4.1517 7.585 1.8361 7.2359
SiSo GDSC1; GDSC2 4.186 10.4931 0.4285 15.3014
HT-3 GDSC1; GDSC2 4.1949 12.2191 -0.4217 19.4457
DSH1 GDSC1; GDSC2 4.2134 7.8034 1.7737 7.4731
JEG-3 GDSC1; GDSC2 4.2629 6.8144 2.2839 4.2864
C-4-I GDSC1; GDSC2 4.3196 6.54 2.4488 3.2115
JHOS-3 GDSC1; GDSC2 4.5235 7.2736 2.2351 4.0699
PWR-1E GDSC1; GDSC2 4.5394 8.5581 1.6359 7.5712
OVCA433 GDSC1; GDSC2 4.5405 10.782 0.5524 13.7443
UWB1.289 GDSC1; GDSC2 4.5655 7.982 1.9289 5.7802
JAR GDSC1; GDSC2 4.571 10.4725 0.7266 12.7264
PEO1 GDSC1; GDSC2 4.6114 10.1747 0.9017 11.6606
SKG-IIIa GDSC1; GDSC2 4.7753 11.2401 0.499 13.4621
SW954 GDSC2 4.9433 7.202 2.5084 1.9368
HeLa GDSC1; GDSC2 6.2626 16.6707 -1.089 17.4288
HEC-1 GDSC1; GDSC2 7.1374 18.7454 -1.4885 17.22
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug

References

1 Identification of a chemical probe for bromo and extra C-terminal bromodomain inhibition through optimization of a fragment-derived hit. J Med Chem. 2012 Nov 26;55(22):9831-7.
2 BRD4 is a novel therapeutic target for liver fibrosis. Proc Natl Acad Sci U S A. 2015 Dec 22;112(51):15713-8. doi: 10.1073/pnas.1522163112. Epub 2015 Dec 7.