Details of the Drug

General Information of Drug (ID: DMVG9YN)

• Drug Name: Fencamfamine
• Synonyms: Euvitol; Fenacamfamin; Fencamfamin; Fencamfamina; Fencamfaminum; Fencanfamina; Reactivan; Fencamfamina [DCIT]; Fencamfamin (INN); Fencamfamin [INN:BAN]; Fencamfamine [INN-French]; Fencamfaminum [INN-Latin]; Fencanfamina [INN-Spanish]; Glucoenergan (TN); Reactivan (TN); N-ethyl-2-phenylbicyclo[2.2.1]heptan-3-amine; N-ethyl-3-phenylbicyclo(2.2.1)heptan-2-amine; 2-Ethylamino-3-phenylnorbornane; 2-Phenyl-3-ethylaminobicyclo(2.2.1)heptane; 2-ethylamino-3-phenylnorcamphane; 3-Phenyl-N-ethyl-2-norbornanamine

Indication

Disease Entry	ICD 11	Status	REF
Depressive fatigue	MG22	Withdrawn from market	[1]

• Therapeutic Class: Central Nervous System Stimulants
• Affected Organisms: Humans and other mammals
• ATC Code:
  N06BA06: Fencamfamine
  N06BA: Centrally acting sympathomimetics
  N06B: PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS
  N06: PSYCHOANALEPTICS
  N: NERVOUS SYSTEM
• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight (mw); 215.33
  Logarithm of the Partition Coefficient (xlogp); 3.3
  Rotatable Bond Count (rotbonds); 3
  Hydrogen Bond Donor Count (hbonddonor); 1
  Hydrogen Bond Acceptor Count (hbondacc); 1
• Chemical Identifiers:
  Formula: C15H21N
  IUPAC Name: N-ethyl-3-phenylbicyclo[2.2.1]heptan-2-amine
  Canonical SMILES: CCNC1C2CCC(C2)C1C3=CC=CC=C3
  InChI: InChI=1S/C15H21N/c1-2-16-15-13-9-8-12(10-13)14(15)11-6-4-3-5-7-11/h3-7,12-16H,2,8-10H2,1H3
  InChIKey: IKFBPFGUINLYQI-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 14584
  ChEBI ID: CHEMBL134895
  CAS Number: 1209-98-9
  UNII: NME1I5IGBK
  DrugBank ID: DB01463
  TTD ID: D0P3DM
• Drug ADMET Endpoint Profile (DAE)NEW: Click to Jump to the Detailed DAE Information of This Drug

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dopamine D2 receptor (D2R)	TTEX248	DRD2_HUMAN	Agonist	[2]

Molecular Expression Atlas of This Drug

• The Studied Disease: Depressive fatigue
• ICD Disease Classification: MG22

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Dopamine D2 receptor (D2R)	DTT	DRD2	2.50E-02	-0.08	-0.49

References

• [1] Drug information of Fencamfamine, 2008. eduDrugs.
• [2] Dopamine uptake inhibiting versus dopamine releasing properties of fencamfamine: an in vitro study. Biochem Pharmacol. 1983 Aug 1;32(15):2329-31.