Details of the Drug

General Information of Drug (ID: DMVIMQX)

Drug Name
ZSTK474
Synonyms
ZSTK474; 475110-96-4; ZSTK-474; 4,4'-(6-(2-(Difluoromethyl)-1H-benzo[d]imidazol-1-yl)-1,3,5-triazine-2,4-diyl)dimorpholine; ZSTK 474; TCMDC-137004; UNII-K0068GK39A; CHEMBL586702; CHEBI:90545; K0068GK39A; 2-(2-difluoromethylbenzimidazol-1-yl)-4,6-dimorpholino-1,3,5-triazine; 2-(2-Difluoromethylbenzimidazol-1-yl)-4,6-bis(morpholino)-1,3,5-triazine; AK-40326; 2-(Difluoromethyl)-1-(4,6-Dimorpholin-4-Yl-1,3,5-Triazin-2-Yl)-1h-Benzimidazole; C19H21F2N7O2; 2wxl; PubChem22461; SCHEMBL373282; QCR-72; GTPL7965; CTK8B6247; SYN1099
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 1 [1]
Therapeutic Class
Anticancer Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 417.4
Logarithm of the Partition Coefficient (xlogp) 2.3
Rotatable Bond Count (rotbonds) 4
Hydrogen Bond Donor Count (hbonddonor) 0
Hydrogen Bond Acceptor Count (hbondacc) 10
Chemical Identifiers
Formula
C19H21F2N7O2
IUPAC Name
4-[4-[2-(difluoromethyl)benzimidazol-1-yl]-6-morpholin-4-yl-1,3,5-triazin-2-yl]morpholine
Canonical SMILES
C1COCCN1C2=NC(=NC(=N2)N3C4=CC=CC=C4N=C3C(F)F)N5CCOCC5
InChI
InChI=1S/C19H21F2N7O2/c20-15(21)16-22-13-3-1-2-4-14(13)28(16)19-24-17(26-5-9-29-10-6-26)23-18(25-19)27-7-11-30-12-8-27/h1-4,15H,5-12H2
InChIKey
HGVNLRPZOWWDKD-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
11647372
ChEBI ID
CHEBI:90545
CAS Number
475110-96-4
UNII
K0068GK39A
DrugBank ID
DB12904
TTD ID
D0O1LD
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
PI3-kinase gamma (PIK3CG) TTHBTOP PK3CG_HUMAN Modulator [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA) OTTOMI8J PK3CA_HUMAN Gene/Protein Processing [3]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PIK3CB) OTO8JQJA PK3CB_HUMAN Gene/Protein Processing [3]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PIK3CD) OTOMP6TH PK3CD_HUMAN Gene/Protein Processing [3]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Post-Translational Modifications [3]
Small ribosomal subunit protein eS6 (RPS6) OTT4D1LN RS6_HUMAN Post-Translational Modifications [4]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Solid tumour/cancer
ICD Disease Classification 2A00-2F9Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
PI3-kinase gamma (PIK3CG) DTT PIK3CG 1.98E-01 -0.05 -0.55
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 42 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1 -0.2076 6.5543 -2.133 39.8623
ES7 GDSC1 -4.064 1.1898 -4.3699 69.7789
ES5 GDSC1 -2.8579 1.0746 -3.0424 62.0784
EW-1 GDSC1 -2.7263 1.0001 -2.8878 61.0729
EW-11 GDSC1 -2.3881 2.3742 -2.8264 56.7343
EW-18 GDSC1 -2.2768 1.5 -2.4946 56.4816
EW-7 GDSC1 -1.4794 2.364 -1.8318 48.3236
CADO-ES1 GDSC1 -1.4521 5.0144 -2.7388 48.5834
ES4 GDSC1 -1.432 3.6653 -2.1972 48.1542
ES6 GDSC1 -1.2433 4.2142 -2.1994 46.6643
HuO9 GDSC1 -1.0866 3.5175 -1.7718 44.8461
ES1 GDSC1 -1.047 6.4917 -2.9508 46.0917
MHH-ES-1 GDSC1; CTRP2 -0.8734 3.7956 -1.0313 46.3125
NOS-1 [Human HNSCC] GDSC1 -0.8342 5.3706 -2.2418 43.8568
ES8 GDSC1 -0.7109 3.9746 -1.5392 41.4995
EW-13 GDSC1 -0.4981 8.8 -3.471 43.7248
SK-ES-1 GDSC1; CTRP2 -0.1661 3.5767 -0.2528 41.6032
EW-16 GDSC1 0.0152 4.3574 -0.9281 34.4831
TC-71 GDSC1 0.2323 4.5 -0.7639 32.4131
Hs 888.T CTRP2 0.4836 6.9482 -0.2931 39.03
EW-3 GDSC1 0.5809 6.5539 -1.3585 33.1506
H-EMC-SS GDSC1 1.673 7.1717 -0.6422 24.6057
SK-PN-DW GDSC1 1.6869 7.9779 -1.0302 26.5698
A-673 GDSC1; CTRP2 1.7646 5.6081 1.4852 29.4552
HuO-3N1 GDSC1 1.7914 12.1551 -3.0216 33.4235
SaOS-2 GDSC1; CTRP2 2.6662 9.2503 1.1696 27.7
CHSA0011 GDSC1 2.9414 7.4774 0.2654 14.0874
NY GDSC1 3.6306 11.0041 -0.2416 22.0717
EW-24 GDSC1 3.8697 5.0835 1.9557 0.4321
CHSA8926 GDSC1 3.9569 13.0344 -1.7147 21.931
CHSA0108 GDSC1 4.3041 8.1715 0.8668 6.2078
TC71 CTRP2 4.316 9.2901 2.8251 17.2419
G-292 clone A141B1 GDSC1; CTRP2 4.352 14.3544 0.4066 25.5955
SK-N-MC CTRP2 4.6587 12.6919 1.5053 21.3543
MG-63 GDSC1; CTRP2 5.0972 14.1359 1.1846 21.4491
CAL-72 GDSC1 5.1633 7.012 1.7581 0.3676
U2OS GDSC1; CTRP2 5.9891 21.2581 -1.6085 27.1834
SJSA-1 GDSC1; CTRP2 6.1431 14.7945 1.7513 17.2963
CAL-78 GDSC1; CTRP2 7.0402 15.8995 1.9201 15.0042
Hs 822.T CTRP2 7.6382 19.154 0.7659 17.856
HOS GDSC1; CTRP2 10.271 20.379 2.0189 9.8259
SW1353 CTRP2 12.7487 31.2073 -1.4842 16.7346
⏷ Show the Full List of 42 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 209 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MEC1 CTRP2 1.6063 7.1799 0.8493 32.0165
JK1 CTRP2 7.057 14.1738 2.7897 11.6939
JM1 GDSC1; CTRP2 4.0581 12.8921 0.8511 24.9622
Ri-1 CTRP2 -7.9105 4.4343 -8.7775 73.3746
SU-DHL-6 GDSC1; CTRP2 -7.7534 -4.4481 -7.7537 88.2232
HAL-01 GDSC1 -5.9415 -1.7913 -5.9877 85.7119
YT GDSC1 -5.9121 1.7971 -6.5209 75.2148
EB2 GDSC1 -5.8109 0.1954 -6.0734 79.0236
HH [Human lymphoma] GDSC1 -5.3304 7.9365 -8.0153 64.3309
NK-92MI GDSC1 -5.3214 8.7207 -8.3315 63.5946
P30/OHK GDSC1 -4.5946 0.2851 -4.7808 74.6205
Karpas-45 GDSC1 -4.4626 -0.4816 -4.5448 76.2557
BL-41 GDSC1 -4.4121 -0.7709 -4.467 76.8905
QIMR-WIL GDSC1 -4.2909 4.3551 -5.5277 65.0619
MLMA GDSC1 -4.2886 1.1505 -4.6055 70.98
Farage GDSC1 -4.1217 -0.5935 -4.1775 74.751
GDM-1 GDSC1 -4.084 -0.5459 -4.142 74.3907
SU-DHL-5 GDSC1 -4.0647 -2.0886 -4.0661 78.478
LC4-1 GDSC1 -4.0487 8.3713 -6.859 60.079
NKM-1 GDSC1 -4.0306 2.5739 -4.6745 66.7764
ARH-77 GDSC1 -3.7712 2.5218 -4.3768 65.5853
NALM-6 GDSC1; CTRP2 -3.7169 3.2179 -3.991 62.3142
ML-2 GDSC1 -3.6331 0.2443 -3.7478 69.4701
697 GDSC1 -3.5957 0.713 -3.7757 68.1589
NCI-H929 CTRP2 -3.2263 -0.4893 -3.2278 61.6852
Reh GDSC1 -3.0963 1.4322 -3.3698 63.3511
CESS GDSC1 -2.8925 0.5854 -3.0034 63.1087
PL-21 GDSC1 -2.8629 1.7453 -3.1851 61.155
WSU-DLCL2 GDSC1; CTRP2 -2.8402 -0.9699 -2.8403 59.1864
KMS-26 CTRP2 -2.7664 -1.2544 -2.7664 58.6982
WIL2 NS GDSC1 -2.7124 2.2426 -3.1447 59.3939
CCRF-CEM GDSC1 -2.5831 0.6771 -2.6858 60.1742
ATN-1 GDSC1 -2.5247 0.8224 -2.6436 59.4568
ALL-PO GDSC1 -2.4585 3.5415 -3.2638 56.3311
CA46 GDSC1 -2.4485 2.7388 -2.9966 56.9011
Hs 445 GDSC1 -2.3412 12.5461 -7.0371 52.4988
Loucy GDSC1 -2.3297 0.0606 -2.3586 58.1232
P32/ISH GDSC1 -2.3216 2.865 -2.8964 55.8217
KMS-34 CTRP2 -2.2766 0.7629 -2.2833 55.3849
MOLM-13 GDSC1; CTRP2 -2.2411 3.8508 -2.5072 54.5416
SIG-M5 GDSC1; CTRP2 -2.0939 2.1087 -2.1475 54.0522
SUP-M2 GDSC1 -2.0869 1.4805 -2.2847 54.6606
MOLT-4 GDSC1 -2.0264 1.5629 -2.2357 54.0154
Namalwa GDSC1 -2.0217 2.627 -2.4982 53.4802
SU-DHL-16 GDSC1 -1.977 -0.5718 -1.9785 54.1479
RS4;11 GDSC1; CTRP2 -1.7499 7.7603 -2.9853 51.3481
BC-1 GDSC1 -1.7139 3.2996 -2.3749 50.6169
MN-60 GDSC1 -1.672 3.5489 -2.415 50.2418
Kasumi-2 CTRP2 -1.6675 8.6177 -3.1923 50.9159
RCH-ACV CTRP2 -1.6582 10.8512 -4.0306 50.7601
MY-M12 GDSC1 -1.6548 4.8232 -2.8758 50.0805
VAL GDSC1 -1.6346 5.5764 -3.1623 49.9368
KE-37 GDSC1; CTRP2 -1.3223 2.6124 -1.3799 49.1057
Pfeiffer CTRP2 -1.2963 4.794 -1.6633 49.0419
TUR GDSC1 -1.2731 1.7785 -1.4631 45.8629
HC-1 GDSC1 -1.2028 12.3733 -5.8581 48.2757
TK [Human B-cell lymphoma] GDSC1 -1.0712 5.3372 -2.4739 45.7483
NB4 GDSC1 -1.009 4.5406 -2.0794 44.7826
Ramos.2G6.4C10 GDSC1 -0.9259 3.5084 -1.5953 43.2294
GR-ST GDSC1 -0.8911 3.2048 -1.451 42.599
NOMO-1 GDSC1 -0.8255 6.3688 -2.6707 44.4485
Hs 611.T CTRP2 -0.814 8.4544 -2.2136 46.9391
OCI-AML-3 GDSC1; CTRP2 -0.8086 4.1615 -1.0173 45.9633
SR GDSC1; CTRP2 -0.7902 3.3291 -0.8857 45.6968
NU-DUL-1 GDSC1; CTRP2 -0.7831 11.7492 -3.4787 47.3974
SUP-T1 GDSC1; CTRP2 -0.7831 4.7866 -1.1047 45.9346
JVM-2 GDSC1; CTRP2 -0.7766 12.5482 -3.8115 47.4939
VL51 GDSC1 -0.5817 6.5516 -2.5064 42.7647
OPM-2 GDSC1; CTRP2 -0.5409 2.6806 -0.5734 43.9499
HT GDSC1; CTRP2 -0.5352 5.4755 -0.9892 44.5916
MHH-PREB-1 GDSC1 -0.5349 3.0883 -1.0254 38.5207
KMS-12-BM GDSC1; CTRP2 -0.4038 5.1578 -0.772 43.6666
Daudi GDSC1; CTRP2 -0.3667 3.0952 -0.4197 42.8452
KHM-1B CTRP2 -0.364 4.6306 -0.6203 43.2311
BL-70 CTRP2 -0.3398 1.9162 -0.3439 42.5447
BC-3 GDSC1 -0.323 2.7915 -0.6972 35.5712
KMS-21-BM CTRP2 -0.2826 4.9647 -0.5984 42.8242
MV4-11 GDSC1; CTRP2 -0.2249 15.5481 -4.5831 46.0573
NU-DHL-1 CTRP2 -0.1753 6.8353 -0.9748 42.9553
SUP-T11 CTRP2 -0.1351 7.8671 -1.2725 43.1944
KMOE-2 GDSC1 0.0251 4.014 -0.775 33.7077
THP-1 GDSC1; CTRP2 0.0452 5.3244 -0.3211 40.8623
EoL-1 GDSC1; CTRP2 0.0831 3.3623 0.0292 39.873
GA-10 CTRP2 0.1207 3.6843 0.0387 39.7016
BALL-1 GDSC1 0.2187 4.3274 -0.7037 32.1917
L-363 GDSC1; CTRP2 0.2233 9.8451 -1.637 42.2559
LP-1 GDSC1; CTRP2 0.2718 5.886 -0.2129 39.6968
DoHH2 CTRP2 0.3238 17.7048 -5.0415 44.7664
KOPN-8 GDSC1 0.3643 7.0559 -1.8068 35.8792
RPMI-8226 GDSC1; CTRP2 0.3791 5.1753 0.0755 38.5897
A4/Fukuda GDSC1; CTRP2 0.3841 7.7868 -0.6833 40.1884
JSC-1 GDSC1 0.4047 7.6346 -2.0448 36.4156
Sc-1 GDSC1 0.4623 6.6854 -1.5357 34.4398
MOLM-16 CTRP2 0.4836 27.5647 -9.6407 46.181
Mono-Mac-1 CTRP2 0.489 9.4351 -1.1917 40.6457
MOLP-8 GDSC1; CTRP2 0.6005 7.0289 -0.192 38.3588
Karpas-422 GDSC1; CTRP2 0.6431 8.4222 -0.6356 39.1127
MEG-01 GDSC1 0.7276 6.4106 -1.1486 31.5229
KG-1 GDSC1 0.7822 5.9012 -0.8532 29.8632
KMS-18 CTRP2 0.8738 4.7659 0.6922 35.0221
A3/Kawakami GDSC1 0.9154 5.6913 -0.6244 28.0055
KMS-28BM CTRP2 0.9243 4.6552 0.7654 34.6191
EB1 CTRP2 0.9602 6.4884 0.3685 35.637
KE-97 CTRP2 1.1426 11.4965 -1.3766 38.6814
HuT 78 CTRP2 1.1586 6.1451 0.6845 34.038
EJM GDSC1; CTRP2 1.1696 7.8624 0.1367 35.492
CTV-1 GDSC1 1.1699 8.6968 -1.85 32.2426
Granta-519 GDSC1; CTRP2 1.3605 10.8207 -0.8575 37.0395
AML-193 CTRP2 1.4216 6.2378 0.9452 32.3435
SET-2 CTRP2 1.4459 5.5197 1.1589 31.584
KMS-11 GDSC1; CTRP2 1.4697 10.1948 -0.4752 35.8965
OCI-Ly19 GDSC1; CTRP2 1.4887 13.3149 -1.8454 38.3459
P12-Ichikawa GDSC1; CTRP2 1.5476 8.6151 0.2559 33.8895
Jiyoye GDSC1 1.624 4.0531 0.8405 14.8794
JURL-MK1 GDSC1; CTRP2 1.6285 7.2486 0.8499 31.9409
MOLT-16 GDSC1; CTRP2 1.7076 13.4623 -1.6955 37.457
KMS-27 CTRP2 1.7177 7.6819 0.7923 31.8194
OCI-AML-2 GDSC1 1.7972 5.8788 0.1098 19.4308
Kasumi-1 GDSC1; CTRP2 1.8671 11.8805 -0.8109 35.3476
TALL-1 [Human adult T-ALL] CTRP2 1.8792 7.5704 1.0066 30.6392
U-937 CTRP2 1.9747 5.7831 1.6716 28.1455
MOLT-13 GDSC1 2.0418 3.6742 1.4197 8.6081
ROS-50 GDSC1 2.1801 8.2737 -0.7506 23.1417
HL-60 GDSC1; CTRP2 2.1923 10.1071 0.3098 31.6843
DEL GDSC1; CTRP2 2.2239 5.3018 2.0517 26.0408
M-07e CTRP2 2.2351 14.0108 -1.4327 35.4826
RPMI-8866 GDSC1 2.2851 6.5799 0.1848 16.9643
KMS-20 CTRP2 2.2991 11.1784 -0.0575 32.3216
U-698-M GDSC1 2.3731 6.5698 0.2634 16.087
SCC-3 GDSC1 2.379 4.5042 1.3011 8.2348
OCI-Ly3 CTRP2 2.4239 7.3482 1.6737 26.735
L-1236 GDSC1 2.4515 7.0405 0.0929 16.9714
JVM-3 GDSC1; CTRP2 2.5067 9.2986 0.9836 28.7638
CTB-1 GDSC1 2.5332 10.503 -1.5707 25.8098
Karpas-299 GDSC1 2.5479 8.4939 -0.5544 20.6688
EM-2 GDSC1; CTRP2 2.6219 13.4005 -0.7672 33.0603
RC-K8 GDSC1 2.8087 4.0096 1.8693 2.4762
RPMI-6666 GDSC1; CTRP2 2.8161 11.4237 0.3487 29.7409
KY821 GDSC1 2.8427 6.4323 0.708 11.2266
Raji GDSC1 2.8856 5.4551 1.2227 7.1844
Mono-Mac-6 GDSC1; CTRP2 2.9219 31.2645 -9.2538 41.8103
WSU-NHL GDSC1 2.938 11.3802 -1.6806 24.9025
DG-75 GDSC1 2.97 6.9181 0.5644 11.8723
DB GDSC1; CTRP2 3.0563 6.2812 2.7158 21.1044
EHEB CTRP2 3.1055 19.8331 -3.43 36.434
BE-13 GDSC1 3.1516 9.7686 -0.7098 19.4721
Ki-JK CTRP2 3.2011 16.0613 -1.4941 33.0428
HPB-ALL CTRP2 3.3956 7.1882 2.7769 19.8823
SEM CTRP2 3.4861 9.7254 1.7975 23.2583
ALL-SIL GDSC1; CTRP2 3.5564 15.4115 -0.8456 30.7834
ST486 GDSC1; CTRP2 3.6525 10.8555 1.4395 24.0679
MOLP-2 CTRP2 3.6578 11.9049 0.9471 25.6743
HD-MY-Z CTRP2 3.7139 7.9368 2.8168 18.8424
PF-382 GDSC1; CTRP2 3.734 15.4359 -0.6927 29.9908
RL GDSC1; CTRP2 3.7709 8.6433 2.5716 19.6279
Mino CTRP2 3.925 8.0003 3.0098 17.529
H9 GDSC1 4.4088 13.8511 -1.7833 20.9786
JeKo-1 CTRP2 4.4193 11.6392 1.7993 20.8801
DND-41 GDSC1; CTRP2 4.9062 17.4194 -0.6174 27.0959
KYO-1 CTRP2 4.9787 9.8429 3.1974 14.1691
RPMI-8402 GDSC1; CTRP2 5.1412 19.371 -1.3858 28.3914
MHH-CALL-3 CTRP2 5.2062 17.8151 -0.5533 26.2884
P31/FUJ GDSC1; CTRP2 5.2132 11.27 2.7103 15.5989
PL21 CTRP2 5.2543 18.529 -0.8679 26.9634
ME1 GDSC1 5.6432 15.5114 -1.7249 17.6742
L-428 GDSC1; CTRP2 5.8627 14.8519 1.4883 18.7871
Ku812 GDSC1; CTRP2 6.2146 22.4891 -2.0366 27.6617
SUP-B15 GDSC1; CTRP2 6.2898 23.2017 -2.3306 28.1131
MHH-CALL-4 CTRP2 6.3995 15.8362 1.4412 17.8859
MM1.S CTRP2 6.5366 21.4912 -1.2727 25.3943
HuNS1 CTRP2 6.6004 15.3762 1.8334 16.1215
Ci-1 CTRP2 6.7232 7.5629 5.7485 0.3981
SK-MM-2 GDSC1; CTRP2 6.7552 15.7262 1.7823 16.0168
KM-H2 GDSC1; CTRP2 6.7751 19.9383 -0.3034 22.5205
MC116 GDSC1; CTRP2 6.8555 22.1124 -1.3241 24.9307
KO52 CTRP2 6.9041 14.0745 2.7214 12.227
SUP-HD1 GDSC1; CTRP2 6.9563 16.6286 1.4918 16.6698
BV-173 GDSC1; CTRP2 6.9998 19.1693 0.2602 20.5206
SU-DHL-4 GDSC1; CTRP2 7.0972 25.0955 -2.6187 27.2472
HDLM-2 GDSC1; CTRP2 7.1005 21.6125 -0.878 23.4183
TF-1 CTRP2 7.4793 12.3785 3.9788 6.2634
Karpas-620 GDSC1; CTRP2 7.4798 9.1759 5.4514 0.7444
SU-DHL-1 GDSC1; CTRP2 7.591 13.335 3.5937 7.6404
CMK CTRP2 7.7352 8.7539 5.717 0.0795
KMM-1 CTRP2 7.8073 14.5103 3.1755 8.9689
NCO2 CTRP2 7.8678 10.0135 5.2948 0.935
HEL 92.1.7 CTRP2 7.9432 9.01 5.703 0.0641
Peer CTRP2 7.9554 18.4489 1.3538 15.4136
OCI-M1 GDSC1; CTRP2 7.9966 9.0379 5.7121 0.0509
SKM-1 CTRP2 8.0357 9.1562 5.6858 0.0677
HEL GDSC1; CTRP2 8.1026 22.7524 -0.6624 21.1522
LAMA-84 GDSC1; CTRP2 8.1393 19.8745 0.7881 16.9473
ME1 CTRP2 8.1856 10.9862 5.0473 1.4514
K-562 GDSC1; CTRP2 8.24 9.6394 5.5929 0.133
MOTN-1 CTRP2 8.2734 18.2215 1.6987 13.7252
MOLM-6 CTRP2 8.3189 18.8968 1.4011 14.6687
SU-DHL-8 GDSC1; CTRP2 8.4934 30.7146 -4.3139 28.0031
CML-T1 CTRP2 8.7217 18.8217 1.7261 12.943
U266B1 GDSC1; CTRP2 8.796 20.656 0.8855 15.6012
L-540 GDSC1; CTRP2 9.222 24.023 -0.4539 18.84
F-36P CTRP2 9.3008 24.133 -0.4505 18.7126
REC-1 CTRP2 10.4703 20.2598 2.1993 8.9753
JJN-3 GDSC1; CTRP2 10.9896 26.7395 -0.5283 16.5514
SU-DHL-10 GDSC1; CTRP2 11.2449 28.0013 -0.9606 17.3232
P3HR-1 CTRP2 11.4567 26.469 -0.086 14.7677
KCL-22 GDSC1; CTRP2 11.493 23.6248 1.2736 10.7606
Jurkat CTRP2 11.8296 24.1871 1.2211 10.5348
AMO1 GDSC1; CTRP2 12.4423 29.6783 -0.9605 15.8378
OCI-AML-5 GDSC1; CTRP2 13.5334 32.7541 -1.7039 16.3433
⏷ Show the Full List of 209 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 28 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE15 CTRP2 3.4143 7.6532 2.6171 20.429
TE8 CTRP2 4.051 10.6524 1.9236 21.3347
TE-15 GDSC1 0.254 8.5563 -2.6324 38.6798
TE-6 GDSC1; CTRP2 0.941 5.449 0.6254 34.9824
KYSE-270 GDSC1 1.2075 4.0077 0.4499 19.7133
TE-5 GDSC1; CTRP2 1.4185 6.5249 0.8571 32.6246
TE-8 GDSC1 2.395 9.7534 -1.3102 25.141
OE21 GDSC1; CTRP2 2.4266 7.8832 1.4766 27.4001
KYSE-410 GDSC1; CTRP2 2.4716 7.9131 1.5131 27.1401
TE-4 GDSC1; CTRP2 2.9408 8.0706 1.949 24.2342
T.T GDSC1 3.4553 5.4569 1.5977 2.9803
KYSE-30 CTRP2 4.8872 12.0809 2.0147 18.9977
OE33 GDSC1; CTRP2 5.4178 22.9077 -2.9149 30.8262
KYSE-510 GDSC1; CTRP2 6.0139 14.6768 1.7028 17.7267
EC-GI-10 GDSC1; CTRP2 6.3237 11.7983 3.3967 10.5658
COLO 680N GDSC1; CTRP2 7.5135 17.8844 1.2997 16.3385
OE19 GDSC1; CTRP2 7.7353 9.1126 5.5891 0.2724
KYSE-140 GDSC1; CTRP2 8.0049 22.4241 -0.5745 21.085
KYSE-150 GDSC1; CTRP2 8.1277 13.718 3.774 6.1714
TE-9 GDSC1; CTRP2 8.3227 9.5349 5.6576 0.0587
KYSE-450 GDSC1; CTRP2 8.3275 16.7903 2.4347 11.0054
TE-14 CTRP2 8.4033 19.2407 1.294 14.8926
TE-11 GDSC1; CTRP2 8.6037 18.1123 1.9873 12.2083
KYSE-520 GDSC1; CTRP2 9.1214 22.6487 0.146 17.3305
TE-10 GDSC1; CTRP2 9.3162 18.5335 2.2709 10.1909
KYSE-70 GDSC1; CTRP2 9.9946 23.3554 0.4188 15.2683
TE-1 GDSC1; CTRP2 11.7409 27.6185 -0.4445 15.3741
KYSE-180 GDSC1; CTRP2 12.992 24.8022 1.6273 8.0901
⏷ Show the Full List of 28 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
N2a-PK1 CTRP2 9.4564 16.2109 3.4447 5.783
KP-1N GDSC1 -3.0502 0.6583 -3.1244 73.6161
HPAF-II GDSC1; CTRP2 0.2114 6.2241 -0.3713 40.2782
MZ-PC-1 GDSC1 0.6774 4.0684 0.2114 32.2643
BxPC-3 GDSC1; CTRP2 0.7108 6.3344 0.142 37.1485
Panc 10.05 GDSC1; CTRP2 1.8493 8.2896 0.7041 31.6518
DAN-G GDSC1; CTRP2 2.21 5.5156 1.9915 26.2936
PL4 GDSC1 2.2208 6.0007 0.9995 20.3828
PaTu 8988s CTRP2 2.4321 8.1024 1.3973 27.6494
SW1990 GDSC1; CTRP2 2.4601 8.4663 1.2816 27.948
KP-4 GDSC1; CTRP2 2.4896 12.9207 -0.6708 33.2183
Capan-1 GDSC1 2.6528 8.6426 -0.5434 20.2293
MIA PaCa-2 GDSC1; CTRP2 2.7384 10.6449 0.6272 29.1649
Hs 766T GDSC1; CTRP2 2.9101 12.4357 -0.0307 30.4992
HuP-T4 GDSC1; CTRP2 2.915 17.963 -2.6887 35.8169
KP-3 GDSC1; CTRP2 2.9863 11.2454 0.6004 28.5409
Panc 08.13 GDSC1; CTRP2 3.1563 13.2752 -0.1904 30.2405
HuP-T3 GDSC1; CTRP2 3.4352 12.8728 0.27 28.2743
SU.86.86 GDSC1; CTRP2 3.5715 9.7362 1.8784 22.7399
Panc 04.03 GDSC1; CTRP2 4.1775 7.8627 3.3305 15.607
Capan-2 GDSC1; CTRP2 4.2011 13.6513 0.6134 25.343
AsPC-1 GDSC1; CTRP2 5.2356 15.4854 0.634 22.9066
PaTu 8902 GDSC1; CTRP2 6.211 13.9048 2.2522 15.3174
Panc 05.04 CTRP2 6.6833 43.9262 -12.3667 38.3927
SNU-410 CTRP2 6.9584 11.2456 4.1606 6.3153
PSN1 GDSC1; CTRP2 7.0476 14.8836 2.4305 13.0962
PaTu 8988t GDSC1; CTRP2 7.5526 9.139 5.5006 0.5614
SNU-213 CTRP2 7.5683 25.8119 -2.5999 26.42
Panc 03.27 GDSC1; CTRP2 7.757 15.5873 2.614 11.2142
SUIT-2 GDSC1; CTRP2 8.1264 9.5289 5.5899 0.1599
KP-2 GDSC1; CTRP2 8.3472 21.0557 0.3608 17.9123
PK-45H CTRP2 9.0052 24.5309 -0.8624 20.2308
TCC-Pan2 CTRP2 9.6121 24.659 -0.4831 18.3393
CFPAC-1 GDSC1; CTRP2 10.0072 20.5887 1.7503 11.0624
QGP-1 GDSC1; CTRP2 10.06 20.7706 1.6987 11.1654
HPAC GDSC1; CTRP2 10.9781 27.8757 -1.0833 17.976
YAPC GDSC1; CTRP2 11.2978 29.2613 -1.5311 18.6316
Panc 02.03 GDSC1; CTRP2 11.4969 22.6303 1.7347 9.3132
PK-59 CTRP2 12.1231 24.3905 1.3059 9.9509
L3.3 CTRP2 15.2867 29.8782 0.6631 8.6915
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 76 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SH4 CTRP2 9.4952 27.947 -2.1809 22.5688
CHL-1 GDSC1 -2.2618 2.3216 -2.6742 55.7263
WM1552C GDSC1 -1.5283 3.8618 -2.3721 49.0291
MZ-MEL-7 GDSC1 -0.8383 6.1292 -2.577 44.3965
A-431 GDSC1 -0.6884 4.7292 -1.8191 42.0508
IST-MEL1 GDSC1 -0.3813 7.8996 -2.9316 42.3858
WM115 GDSC1; CTRP2 -0.2066 6.3222 -0.8554 42.9118
RPMI-7951 GDSC1; CTRP2 -0.0534 4.3896 -0.2425 41.106
MMAc-SF GDSC1 0.0465 7.9829 -2.5554 39.5086
WM35 GDSC1 0.1816 4.8251 -0.9581 33.6273
A-388 GDSC1 1.0405 4.6783 -0.0252 23.7984
LB2518-MEL GDSC1 1.2187 4.5936 0.19 21.4849
WM88 CTRP2 1.3857 5.6292 1.0673 32.0805
MZ-MEL-2 GDSC1 1.5637 6.4501 -0.3837 23.5935
WM266-4 CTRP2 1.6451 7.7856 0.6763 32.4009
HMV-II GDSC1 1.8555 8.0835 -0.9347 25.3969
GAK GDSC1 1.8674 7.5365 -0.6518 23.8449
G-mel GDSC1 1.9048 9.3869 -1.542 28.0159
SK-MEL-24 GDSC1 1.9721 7.1937 -0.3897 21.9065
WM278 GDSC1 2.4107 9.4651 -1.153 24.3388
COLO 679 GDSC1 2.4276 7.2816 -0.0473 17.992
M14 GDSC1 2.6087 5.734 0.8728 10.7622
Hs 895.T CTRP2 2.6162 8.8284 1.2965 27.4329
Mel Ho GDSC1; CTRP2 2.6341 12.1068 -0.1483 31.5734
CP66-MEL GDSC1 2.6753 5.2868 1.1475 8.4233
UACC-62 GDSC1; CTRP2 2.7692 7.5305 1.9772 24.6339
IGR-37 GDSC1; CTRP2 2.8281 11.3035 0.4162 29.5172
CP50-MEL-B GDSC1 2.8361 5.6927 1.069 8.5163
451Lu GDSC1 2.8607 6.2035 0.8351 10.2174
RVH-421 GDSC1; CTRP2 2.904 11.4094 0.4427 29.2279
COLO 783 GDSC1 3.1236 5.9535 1.15 7.0487
Hs 934.T CTRP2 3.1387 15.2031 -1.1358 32.4731
WM983B CTRP2 3.3744 8.5414 2.2074 22.0704
VMRC-MELG GDSC1 3.5518 6.7651 1.0507 6.6512
UACC-257 GDSC1; CTRP2 3.5818 11.9591 0.848 26.1831
SH-4 GDSC1 3.5936 12.0731 -1.5135 22.1058
Hs 688(A).T CTRP2 3.7484 12.3591 0.8162 25.851
HT-144 GDSC1; CTRP2 3.9423 9.9569 2.1453 20.7929
Hs 940.T GDSC1; CTRP2 4.032 11.9533 1.2816 23.6313
MeWo GDSC1; CTRP2 4.0556 11.3997 1.5708 22.5827
LB373-MEL-D GDSC1 4.0594 10.7837 -0.5363 15.7602
DJM-1 GDSC1 4.1876 9.5238 0.1597 11.1792
Hs 938.T GDSC1 4.338 9.4447 1.0864 12.667
COLO 829 GDSC1; CTRP2 4.3709 11.582 1.7816 21.0607
Hs 839.T CTRP2 4.4858 15.1062 0.1569 25.9967
COLO 792 GDSC1; CTRP2 4.6942 17.382 -0.7855 27.973
Hs 294T CTRP2 4.9049 12.6395 1.755 19.9054
WT2-iPS GDSC1; CTRP2 5.5829 12.1945 2.5768 15.3329
SK-MEL-2 GDSC1; CTRP2 7.1467 8.4287 5.5974 0.5473
Hs 944.T CTRP2 7.2694 22.285 -1.079 23.6134
COLO 741 CTRP2 7.3074 12.2086 3.9409 6.6712
A2058 GDSC1; CTRP2 7.4165 8.466 5.7 0.175
G-361 GDSC1; CTRP2 7.4511 22.2836 -0.9348 22.9435
SK-MEL-3 GDSC1; CTRP2 7.5413 16.0856 2.2101 13.0792
CJM [Human melanoma] CTRP2 7.7996 12.5465 4.1139 5.28
SK-MEL-1 GDSC1; CTRP2 7.8454 14.6116 3.1531 8.9989
A-375 GDSC1; CTRP2 7.9348 19.4696 0.8347 17.1381
IGR-1 GDSC1; CTRP2 8.0064 22.3468 -0.535 20.9787
Mel JuSo GDSC1; CTRP2 8.0279 16.3642 2.4296 11.4817
COLO 800 GDSC1; CTRP2 8.6862 19.1333 1.5495 13.5992
A101D GDSC1; CTRP2 8.8693 15.9217 3.2148 7.3362
Hs 852.T CTRP2 9.1835 26.9682 -1.9305 22.485
SK-MEL-28 GDSC1; CTRP2 9.2673 22.8324 0.1612 17.0677
SK-MEL-31 CTRP2 9.5743 18.5385 2.4372 9.2618
IGR-39 CTRP2 9.6909 21.4085 1.1478 13.4585
HMCB CTRP2 9.7657 16.2958 3.5873 4.9427
WM793 GDSC1; CTRP2 9.8682 27.141 -1.5118 20.5323
K029AX CTRP2 9.9217 21.8023 1.1156 13.2417
WM1799 CTRP2 10.0982 24.1044 0.1289 15.9621
MDA-MB-435S CTRP2 11.7504 24.6192 0.9721 11.3769
SK-MEL-5 GDSC1; CTRP2 11.8066 28.0741 -0.6177 15.7431
LOX-IMVI GDSC1; CTRP2 12.0406 25.7925 0.6079 12.1108
SK-MEL-30 GDSC1; CTRP2 12.3793 26.3153 0.5759 11.8155
Hs 936.T CTRP2 13.2317 25.7674 1.333 8.7244
IPC-298 GDSC1; CTRP2 13.4999 28.0744 0.4479 10.9658
EquiPSC Line K2 GDSC1 2.0399 7.7139 -0.5907 22.8054
⏷ Show the Full List of 76 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYAE-1 GDSC1 -3.8253 3.3306 -4.6791 64.5348
OACM5.1 C GDSC1 -2.5778 2.1996 -2.9865 58.4121
OACP4 C GDSC1 -2.5571 1.9542 -2.9016 58.5056
KYSE-50 GDSC1 -2.1688 2.9321 -2.7506 54.5639
TE-12 GDSC1 -0.2698 11.1208 -4.3694 43.7157
KYSE-220 GDSC1 -0.0266 5.893 -1.6486 37.4798
SK-GT-4 GDSC1 0.1432 3.5597 -0.4683 31.3927
ESO-51 GDSC1 0.8034 4.3639 -0.1193 25.6103
ESO-26 GDSC1 0.8374 4.568 -0.1771 25.7969
FLO-1 GDSC1 1.7473 15.316 -4.6379 37.0253
HCE-4 GDSC1 3.7335 10.853 -0.8062 18.192
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1; CTRP2 -0.6345 7.0533 -1.543 45.6568
Cancer Drug Sensitivity Data Curated from 34 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NB69 GDSC1 -1.0601 5.2462 -2.4239 45.6142
SK-N-AS GDSC1 -0.0221 6.3587 -1.8581 38.094
SJNB-5 GDSC1 0.0434 2.2287 -0.1342 30.0283
NH-12 GDSC1 0.5236 6.313 -1.2996 33.2083
CHP-212 GDSC1 0.617 12.2998 -4.1303 39.9757
IMR-32 CTRP2 0.6238 6.2998 0.0571 37.6886
SK-N-DZ GDSC1; CTRP2 1.0569 3.9272 1.0007 33.4127
GI-ME-N GDSC1 1.1752 6.7598 -0.8935 28.1515
SJNB-7 GDSC1 1.2716 3.3955 0.7868 16.9532
TGW GDSC1 1.4823 9.3069 -1.8719 31.0063
SK-N-MC-IXC GDSC1 1.6503 5.1185 0.3502 18.3831
KP-N-YS GDSC1 1.7377 5.8894 0.0509 20.0812
SJNB-12 GDSC1 1.8136 7.8088 -0.8345 25.0513
IMR-5 GDSC1 1.8583 5.4624 0.3709 17.3481
SJNB-6 GDSC1 2.0835 10.0925 -1.7415 28.1526
NB(TU)1 GDSC1 2.7246 9.1765 -0.7521 21.1473
SK-N-FI GDSC1; CTRP2 2.734 8.4078 1.594 26.0831
SK-N-BE(2) CTRP2 2.8108 11.0944 0.495 29.3419
CHP-134 GDSC1 2.8931 10.7698 -1.412 23.8686
SK-N-BE(2)-M17 GDSC1 2.9896 9.1661 -0.5364 19.0267
LA-N-6 GDSC1 3.0764 9.7219 -0.7451 19.913
MHH-NB-11 GDSC1; CTRP2 3.2687 11.507 0.7572 27.2955
SJNB-14 GDSC1 3.4031 6.3813 1.135 6.4121
GOTO GDSC1 3.6165 7.9107 0.5462 10.0914
SiMa GDSC1; CTRP2 3.6943 10.28 1.75 22.8755
SJNB-17 GDSC1 3.7799 9.4463 -0.0838 13.8346
SJNB-10 GDSC1 4.0788 10.161 -0.2206 13.849
SJNB-13 GDSC1 4.0853 6.3399 1.5539 2.1806
NH-6 CTRP2 5.0715 12.9293 1.761 19.5094
SK-N-SH GDSC1; CTRP2 5.5308 17.3901 -0.0619 24.3047
Kelly GDSC1; CTRP2 5.8307 19.1273 -0.676 25.3104
KP-N-YN GDSC1; CTRP2 9.9057 18.8828 2.4869 8.6699
CHP-126 CTRP2 10.2827 32.8114 -3.9921 24.9536
NB1 CTRP2 10.4347 20.8381 1.9079 9.9954
⏷ Show the Full List of 34 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC1; CTRP2 0.0674 6.4264 -0.5867 41.2892
SNU-1079 CTRP2 0.5993 10.5535 -1.5335 40.7597
SNU-478 CTRP2 1.3756 9.7985 -0.4062 36.058
SNU-245 CTRP2 4.0312 11.58 1.4608 23.0249
SNU-308 CTRP2 5.3498 18.8215 -0.9319 26.9175
HuH-28 CTRP2 6.0004 16.9391 0.5603 21.5347
SNU-1196 CTRP2 8.1283 16.5793 2.3965 11.4492
SNU-869 CTRP2 8.2818 14.6426 3.4365 7.271
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 91 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCC70 GDSC1 -1.7262 2.743 -2.0357 55.181
BT-483 GDSC1 -1.5003 14.7786 -7.3028 49.527
OCUB-M GDSC1 -0.9348 1.8102 -1.1024 41.8636
Evsa-T GDSC1 -0.916 2.1667 -1.1649 41.9335
HCC1187 GDSC1 -0.8033 4.9516 -2.0321 43.2761
MDA-MB-361 GDSC1; CTRP2 -0.7752 3.0986 -0.8474 45.5641
YMB-1-E GDSC1 -0.7165 5.9018 -2.352 43.3
HCC1954 GDSC1; CTRP2 -0.6632 2.7747 -0.7056 44.7776
MDA-MB-175-VII GDSC1 -0.6481 2.0479 -0.7385 44.7724
AU565 GDSC1; CTRP2 -0.3864 5.5852 -0.8539 43.7124
UACC-812 GDSC1 -0.3364 5.5276 -1.7981 39.7483
UACC-893 GDSC1 -0.3151 1.8353 -0.3601 40.9977
HCC1599 GDSC1 -0.0355 4.7684 -1.1565 35.7651
MDA-MB-415 GDSC1 0.008 5.2543 -0.9475 40.6598
HCC1569 GDSC1; CTRP2 0.0415 5.9271 -0.4751 41.188
MDA-MB-453 GDSC1; CTRP2 0.2756 3.682 0.2023 38.653
HCC1419 GDSC1; CTRP2 0.4342 5.8043 -0.0143 38.5942
EFM-19 GDSC1 0.5402 7.0733 -1.6458 34.4423
BT-20 GDSC1; CTRP2 0.546 5.8718 0.0901 37.9049
MDA-MB-330 GDSC1 0.567 5.8933 -1.0594 31.9519
SK-BR-3 CTRP2 1.1192 6.7834 0.4508 34.8425
T-47D GDSC1; CTRP2 1.1958 11.5437 -1.3428 38.4522
MDA-MB-468 GDSC1; CTRP2 1.4583 10.5779 -0.6514 36.3069
MDA-MB-436 GDSC1 1.4616 8.0569 -0.7135 32.2884
EFM-192A GDSC1; CTRP2 1.6022 5.1907 1.4 30.272
ZR-75-1 CTRP2 1.9899 27.8156 -8.3807 42.946
HCC2157 GDSC1 1.9945 5.9338 0.2577 17.5936
CAL-148 GDSC1 2.3924 5.998 0.5653 13.8405
MRK-nu-1 GDSC1 2.3983 3.4024 1.8677 3.702
ZR-75-30 GDSC1; CTRP2 2.4321 11.0926 0.1156 31.4817
HCC38 GDSC1; CTRP2 2.4854 10.0412 0.6396 29.8688
HCC2218 GDSC1; CTRP2 2.637 12.4083 -0.286 31.9052
CAL-85-1 GDSC1; CTRP2 2.714 10.1005 0.8469 28.5762
KPL-1 CTRP2 2.9225 13.8738 -0.7015 32.0934
HDQ-P1 GDSC1; CTRP2 2.9409 12.7496 -0.1488 30.7175
MFM-223 GDSC1 3.0295 8.2292 -0.0398 15.8456
HCC1937 GDSC1; CTRP2 3.1103 11.5975 0.5591 28.319
DU4475 GDSC1; CTRP2 3.1137 7.7264 2.2692 22.5746
COLO 824 GDSC1 3.2381 8.6213 -0.0752 15.4038
BT-549 GDSC1; CTRP2 3.4411 17.9584 -2.2004 33.7672
HCC1500 GDSC1; CTRP2 3.5723 9.5735 1.9533 22.4665
Hs 578T GDSC1; CTRP2 3.964 10.7785 1.7794 22.0756
CAL-120 GDSC1; CTRP2 4.0818 10.9743 1.7998 21.7059
HCC202 GDSC1; CTRP2 5.335 18.9418 -1.0046 27.1206
BT-474 GDSC1; CTRP2 5.5515 16.1297 0.5854 22.3805
HCC1395 GDSC1; CTRP2 5.5895 15.8784 0.7433 21.8126
CAMA-1 GDSC1; CTRP2 5.9757 14.5579 1.7302 17.7055
CAL-51 GDSC1; CTRP2 6.0438 16.5177 0.8072 20.6806
HCC1806 GDSC1; CTRP2 6.8647 16.7193 1.3742 17.24
Hs 578Bst CTRP2 7.1452 12.3012 3.7792 7.5793
MDA-MB-157 GDSC1; CTRP2 7.7622 14.6038 3.0981 9.3398
HCC1428 GDSC1; CTRP2 8.4131 16.7054 2.5356 10.5055
MCF-7 GDSC1; CTRP2 8.7901 24.7915 -1.1509 21.2787
MDA-MB-231 GDSC1; CTRP2 9.086 20.7745 1.0345 14.6916
HCC1143 CTRP2 10.142 22.2906 1.0302 13.2114
HMC-1-8 CTRP2 11.0243 23.6141 0.9822 12.219
JIMT-1 GDSC1; CTRP2 11.3009 24.5368 0.7259 12.6479
BT 239 CTRP2 1.2665 10.5105 -0.821 37.2782
BT 271 CTRP2 1.308 6.9295 0.6092 33.736
BT 330 CTRP2 1.3591 9.127 -0.1477 35.5277
BT 440 CTRP2 1.6047 11.1032 -0.7301 35.9979
BT 172 CTRP2 1.7548 9.1464 0.2614 33.1932
BT147 CTRP2 1.9128 15.7278 -2.5596 38.1832
BT 145 CTRP2 2.3952 7.9392 1.4216 27.6804
BT 248 CTRP2 2.4375 9.0187 1.03 28.8253
BT 428 CTRP2 2.5187 7.9629 1.544 26.8935
BT 416 CTRP2 2.7126 6.7715 2.1866 24.0511
BT 482 CTRP2 2.7516 10.1477 0.8641 28.4146
BT 504 CTRP2 2.9113 12.2299 0.0672 30.239
BT 131 CTRP2 3.0256 9.2022 1.5616 25.3549
BT 286 CTRP2 3.0884 10.6934 0.9566 27.1734
BT 422 CTRP2 3.391 18.4381 -2.4822 34.3624
BT 359 CTRP2 3.5221 13.7692 -0.0791 28.9953
BT 328 CTRP2 3.5705 10.9021 1.3372 24.6296
BT 231 CTRP2 3.9203 16.9436 -1.2629 30.8239
BT 245 CTRP2 3.964 9.8709 2.2069 20.5074
BT 159 CTRP2 4.0272 17.3229 -1.3531 30.7663
BT 444 CTRP2 4.1405 11.6859 1.5138 22.5698
BT 232 CTRP2 4.2193 11.4854 1.6853 21.7741
BT 179 CTRP2 4.4289 11.9848 1.6399 21.426
BT 340 CTRP2 4.8229 13.8354 1.0894 22.3802
BT 216 CTRP2 5.0892 16.7811 -0.1393 25.4563
BT 139 CTRP2 5.1338 16.5626 0.0085 24.9545
BT 333 CTRP2 5.281 15.5937 0.6195 22.8527
BT 228 CTRP2 5.9739 19.4113 -0.6979 25.0809
BT 112 CTRP2 6.1573 15.7726 1.2741 18.9287
BT164 CTRP2 7.0215 17.3227 1.1974 17.549
BT 320 CTRP2 7.4492 18.644 0.8737 17.8422
BT 187 CTRP2 7.8134 21.6391 -0.3322 20.7609
BT 224 CTRP2 9.8254 19.6133 2.093 10.1382
BT 498 CTRP2 10.5085 28.4939 -1.7126 20.101
⏷ Show the Full List of 91 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Tongue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-38 CTRP2 9.4701 16.9199 3.1272 6.9153
Cancer Drug Sensitivity Data Curated from 68 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MOG-G-UVW GDSC1 -1.6602 3.5523 -2.4035 50.1405
D-423MG GDSC1 -1.2472 5.4334 -2.356 50.7224
KS-1 [Human Krukenberg tumour] GDSC1 -0.5903 5.6817 -2.1258 42.0921
AM-38 GDSC1 -0.2432 4.2419 -1.1506 37.039
D-336MG GDSC1 0.2199 7.8906 -2.3446 38.1507
GI-1 GDSC1 0.3764 4.1708 -0.4732 30.0528
LN-405 GDSC1 0.4197 9.6763 -3.0209 38.7789
Daoy GDSC1; CTRP2 0.8564 7.7007 -0.1428 37.2892
SK-MG-1 GDSC1 0.9557 6.4248 -0.4549 33.7184
YKG-1 GDSC1 1.2852 6.422 -0.6261 26.2384
Hs 683 GDSC1; CTRP2 1.4085 6.7765 0.7678 32.9273
M059J GDSC1 1.5011 6.4661 -0.4486 24.2533
PFSK-1 GDSC1 1.7067 6.3989 -0.2291 22.0287
D283 Med GDSC1; CTRP2 1.7998 5.0195 1.6463 28.7964
Onda 11 GDSC1 1.9475 6.6048 -0.1177 20.3151
CAS-1 GDSC1; CTRP2 1.9528 14.1565 -1.7775 36.8833
KALS-1 GDSC1; CTRP2 2.1875 11.407 -0.2735 33.1847
SF539 GDSC1; CTRP2 2.2636 7.3563 1.498 27.827
GaMG GDSC1; CTRP2 2.2848 10.373 0.2879 31.4623
D-247MG GDSC1 2.3443 8.1934 -0.5724 21.5235
GB-1 GDSC1; CTRP2 2.3949 10.1804 0.4856 30.5828
SW1088 GDSC1; CTRP2 2.4217 9.7451 0.7035 29.8707
KNS-81-FD GDSC1 2.4963 7.1766 0.0617 17.0174
D-502MG GDSC1 2.6632 13.3144 -2.8693 30.0726
NMC-G1 GDSC1; CTRP2 2.813 11.708 0.2141 30.1203
SF126 GDSC1; CTRP2 2.892 9.9726 1.0851 27.3186
H4 GDSC1 2.9642 8.8034 -0.3758 18.165
D-392MG GDSC1 2.9738 12.7338 -2.3274 27.3056
D-542MG GDSC1 3.1889 8.262 0.0652 14.6443
SF268 GDSC1; CTRP2 3.2538 10.9231 1.0151 26.5332
D-263MG GDSC1 3.3636 5.9186 1.3283 5.0953
SNB-75 GDSC1; CTRP2 3.4522 11.8698 0.765 26.7804
YH-13 GDSC1; CTRP2 3.8368 14.9381 -0.3538 28.9117
LNZTA3WT4 GDSC1 3.8649 11.7181 -1.1347 19.5062
D-566MG GDSC1 3.9108 6.1735 1.5344 2.5687
42-MG-BA GDSC1; CTRP2 4.3072 12.9142 1.0726 23.6456
Onda 10 GDSC1 4.6743 12.5138 -0.9446 16.3306
KINGS-1 GDSC1 4.7015 10.111 0.2155 9.5821
U-118MG GDSC1; CTRP2 4.8966 11.3205 2.3978 17.5282
KG-1-C CTRP2 4.9263 18.2497 -1.0133 28.0041
KNS-42 GDSC1 5.0473 14.9803 -1.8782 19.7419
MOG-G-CCM GDSC1 5.4597 22.0843 -5.0561 28.5171
SF295 GDSC1; CTRP2 5.4622 16.3184 0.4146 23.0835
Becker GDSC1; CTRP2 5.5423 16.1354 0.5746 22.4327
ONS-76 GDSC1; CTRP2 6.1107 15.0402 1.6016 17.892
KNS-60 CTRP2 6.1655 15.2082 1.563 17.9193
SNU-626 CTRP2 6.5306 14.2462 2.3413 14.3705
SNU-738 CTRP2 6.9314 15.6939 1.9375 15.1363
U-87MG ATCC GDSC1; CTRP2 6.9977 20.4662 -0.3883 22.3404
U-251MG GDSC1; CTRP2 7.0808 18.5725 0.6217 19.2861
T98G GDSC1; CTRP2 7.1089 15.3779 2.2324 13.7352
DK-MG GDSC1; CTRP2 7.1299 17.9093 0.9906 18.0321
KNS-81 CTRP2 7.1877 14.1438 2.9035 11.0253
SW1783 GDSC1; CTRP2 7.4872 15.2752 2.5692 11.8212
SNU-489 CTRP2 7.5004 19.0303 0.7214 18.2329
SNU-466 CTRP2 7.8409 14.6923 3.1108 9.1708
GMS-10 CTRP2 8.195 19.8818 0.826 16.7376
M059K CTRP2 8.3799 21.3802 0.2252 18.2584
LN-18 GDSC1; CTRP2 8.4919 15.3964 3.2171 7.8262
SNU-1105 CTRP2 9.9703 30.6935 -3.181 23.9094
A-172 GDSC1; CTRP2 10.3386 24.3329 0.1842 15.4736
SNU-201 CTRP2 10.4191 21.9396 1.3801 11.7395
GOS-3 CTRP2 10.7786 24.2612 0.5151 13.9299
LN-229 GDSC1; CTRP2 10.9642 22.0106 1.6939 10.0566
CCF-STTG1 CTRP2 11.0272 22.6727 1.4252 10.8393
DBTRG-05MG GDSC1; CTRP2 11.7253 27.1793 -0.2463 14.8676
TM-31 CTRP2 12.5442 27.775 0.0003 13.2296
8-MG-BA GDSC1; CTRP2 13.5127 26.7512 1.0535 9.2555
⏷ Show the Full List of 68 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TGBC24TKB GDSC1 0.3857 6.1578 -1.3614 34.1815
ETK-1 GDSC1 1.8121 6.9896 -0.4283 22.7942
TGBC1TKB GDSC1 2.4611 8.885 -0.8213 22.4651
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MFE-280 GDSC1 -0.9267 6.3258 -2.7545 45.1614
JHUEM-1 CTRP2 1.2699 3.4499 1.2539 31.8617
AN3-CA GDSC1; CTRP2 2.0637 10.9779 -0.206 33.3978
MFE-296 GDSC1; CTRP2 2.0763 7.0877 1.39 28.7739
HEC-1-A CTRP2 2.2411 8.5135 1.0313 29.4205
JHUEM-3 CTRP2 2.55 7.291 1.8301 25.8083
JHUEM-7 CTRP2 3.0941 11.1123 0.769 27.7374
EFE-184 CTRP2 3.7921 12.0333 1.0146 25.1133
HEC-151 CTRP2 4.6249 8.5882 3.4573 13.9586
JHUEM-2 CTRP2 4.9884 18.0611 -0.8652 27.5216
KLE GDSC1; CTRP2 5.539 16.657 0.3112 23.2267
ESS-1 GDSC1; CTRP2 6.3194 14.1744 2.2062 15.2813
HEC-59 CTRP2 6.4953 15.9471 1.4636 17.6251
HEC-265 CTRP2 6.5118 8.0161 5.4157 1.8652
MFE-319 GDSC1; CTRP2 7.5663 10.7356 4.8131 2.8705
HEC-108 CTRP2 7.6376 9.0518 5.5718 0.3464
HEC-6 CTRP2 7.9878 9.2291 5.6438 0.1188
HEC-251 CTRP2 8.0845 14.9643 3.1489 8.6613
HEC-1-B CTRP2 8.7516 18.0034 2.143 11.4374
HEC-50B CTRP2 8.7994 16.7095 2.7961 8.99
EN GDSC1; CTRP2 11.11 23.2335 1.2155 11.3958
RL95-2 GDSC1; CTRP2 11.9284 23.4765 1.6068 9.2402
Ishikawa (Heraklio) 02 ER- CTRP2 7.6319 8.7049 5.6965 0.1236
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KTCTL-21 GDSC1 -1.799 2.0039 -2.0874 51.5893
UO-31 GDSC1; CTRP2 -1.5817 4.223 -1.861 50.7173
KTCTL-140 GDSC1 -1.4282 3.3027 -2.0662 48.0324
LB1047-RCC GDSC1 -1.2903 3.1527 -1.6606 51.3099
KTCTL-195 GDSC1 -1.279 5.5371 -2.7748 47.4109
KTCTL-1M GDSC1 -0.9052 3.3423 -1.5139 42.8722
SW156 GDSC1 -0.2688 6.1332 -1.5949 43.7247
HA7-RCC GDSC1 -0.2424 4.2081 -0.8328 41.9906
KTCTL-26A GDSC1 -0.1791 5.4182 -1.5891 38.1825
NCC021 GDSC1 -0.1313 13.6671 -5.4859 44.1994
BB65-RCC GDSC1 -0.0789 5.2266 -1.0291 41.4102
OS-RC-2 GDSC1; CTRP2 -0.066 12.2704 -2.9573 44.593
RXF 393L GDSC1 0.2702 6.516 -1.1967 39.7611
TK-10 GDSC1 0.6768 6.8773 -0.9407 36.8546
LB996-RCC GDSC1 1.3794 6.4453 -0.0372 29.8343
KTCTL-13 GDSC1 1.5945 15.7797 -5.0005 38.0731
A-704 GDSC1 1.9942 11.9528 -2.747 31.9413
KMRC-2 CTRP2 2.0337 8.8823 0.663 31.1835
769-P GDSC1; CTRP2 2.493 10.8082 0.3056 30.7926
SW13 GDSC1 2.8429 5.997 1.587 14.1169
BFTC-909 GDSC1; CTRP2 2.9277 8.9065 1.5879 25.5427
CAL-54 GDSC1 3.1764 11.4425 -1.5229 23.4424
KMRC-3 CTRP2 4.3198 18.5563 -1.7012 30.8215
TUHR4TKB CTRP2 4.5085 14.0842 0.6823 24.4
LB2241-RCC GDSC1 4.6491 7.7944 2.0998 5.3992
Caki-1 GDSC1; CTRP2 5.1217 17.6752 -0.5567 26.4773
KMRC-1 GDSC1; CTRP2 5.311 14.7879 1.0474 21.4334
SN12C GDSC1 5.4378 17.0342 -1.8351 23.4396
VMRC-RCZ GDSC1; CTRP2 5.4526 12.7198 2.2016 17.0526
TUHR14TKB CTRP2 6.1829 20.0671 -0.8519 25.0563
786-O GDSC1; CTRP2 6.4411 14.6739 2.0557 15.6104
A-498 GDSC1; CTRP2 7.2379 15.6394 2.2016 13.6254
KMRC-20 GDSC1; CTRP2 7.58 19.1503 0.7231 18.0897
VMRC-RCW GDSC1; CTRP2 7.7892 9.7485 5.3654 0.7853
ACHN GDSC1; CTRP2 8.6819 18.6485 1.7821 12.8091
Caki-2 CTRP2 9.4118 21.7396 0.7951 14.9637
TUHR10TKB CTRP2 9.9921 21.0436 1.5246 11.8288
RCC10RGB GDSC1; CTRP2 10.1088 21.8261 1.2296 12.6268
SNU-1272 CTRP2 10.1218 23.7447 0.3187 15.3839
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 56 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-81 GDSC1; CTRP2 -5.1834 9.2487 -7.2125 62.5587
NCI-H747 GDSC1; CTRP2 -1.3136 5.4377 -1.8284 49.1766
SW626 GDSC1 -1.2737 4.6211 -2.3916 47.0766
COLO 320HSR GDSC1 0.2342 6.5044 -1.6728 36.1183
CCK-81 GDSC1 0.2688 6.4819 -1.6283 35.7828
COLO 320 CTRP2 0.333 5.057 0.0505 38.8339
SNU-175 GDSC1; CTRP2 0.3683 5.3465 -1.003 24.1936
SW1463 GDSC1 0.5541 8.7646 -2.4508 36.8432
T84 GDSC1; CTRP2 0.7516 8.5553 -0.5696 38.5833
SW837 GDSC1 0.9649 10.2113 -2.7836 35.9339
KM12 GDSC1; CTRP2 1.0564 14.6275 -2.8815 40.9923
SNU-C1 GDSC1; CTRP2 1.1474 4.7567 0.9886 33.1431
SNU-1040 GDSC1 1.3369 10.3232 -2.5057 33.6783
SNU-C2A CTRP2 1.4052 9.4057 -0.2125 35.5231
RKO GDSC1; CTRP2 1.4953 7.8165 0.5039 33.394
SW48 GDSC1; CTRP2 1.8193 9.3087 0.2623 32.9822
C2BBe1 GDSC1; CTRP2 1.8789 8.9466 0.4737 32.2155
LS1034 GDSC1; CTRP2 2.2109 8.3979 1.0456 29.4687
SW948 GDSC1; CTRP2 2.3954 6.907 1.7971 26.3938
CaR-1 GDSC1 2.5739 9.5385 -1.0552 23.2669
SNU-C2B GDSC1 2.7291 9.5237 -0.9217 22.0366
HCC2998 GDSC1 2.7324 8.3404 -0.3285 18.6732
GP5d GDSC1 2.9885 10.4039 -1.1537 22.3263
SNU-C5 GDSC1; CTRP2 3.7408 9.4198 2.1927 21.139
CL-11 GDSC1; CTRP2 3.9484 10.84 1.7351 22.2736
GP2d CTRP2 4.02 12.9789 0.7732 25.2993
SW1116 GDSC1; CTRP2 4.0775 10.2424 2.1437 20.456
SNU-503 CTRP2 4.1618 12.2844 1.2439 23.435
SW1417 GDSC1; CTRP2 4.5526 12.9475 1.2825 22.3654
LoVo GDSC1; CTRP2 4.8287 12.7153 1.6486 20.4588
HCC-56 CTRP2 5.09 7.7942 4.2865 9.4637
HT115 GDSC1; CTRP2 5.2488 9.1863 3.7695 11.2133
NCI-H716 GDSC1; CTRP2 5.4661 16.3784 0.3879 23.1544
SNU-407 GDSC1; CTRP2 6.4318 20.839 -1.0326 25.022
SK-CO-1 CTRP2 6.5213 16.328 1.2944 18.1531
LS513 GDSC1; CTRP2 6.5282 16.4655 1.2314 18.352
DLD-1 CTRP2 6.6654 11.6892 3.7214 8.6133
HCT 15 GDSC1; CTRP2 6.7111 13.6948 2.7596 12.4207
SNU-C4 CTRP2 7.3149 10.6298 4.7044 3.6003
MDST8 GDSC1; CTRP2 7.3451 20.1514 0.0434 20.5275
SNU-1033 CTRP2 7.4214 18.3335 1.0063 17.465
LS123 GDSC1; CTRP2 7.5901 22.1278 -0.7482 22.2347
COLO205 GDSC1; CTRP2 7.8816 9.1534 5.6312 0.1581
HT-29 GDSC1; CTRP2 7.947 9.0964 5.675 0.0906
RCM-1 [Human ESC] GDSC1; CTRP2 8.0933 13.7982 3.7133 6.4536
LS411N GDSC1; CTRP2 8.0962 9.4242 5.6154 0.1329
HCT 116 GDSC1; CTRP2 8.1521 9.5791 5.5817 0.1653
NCI-H508 CTRP2 8.1986 16.6399 2.4169 11.266
HT-55 GDSC1; CTRP2 8.2191 16.5666 2.467 11.0493
LS180 GDSC1; CTRP2 8.418 9.9476 5.5504 0.1508
CW-2 GDSC1; CTRP2 9.0378 16.5161 3.0435 7.757
SNU-61 GDSC1; CTRP2 9.2445 22.4589 0.3272 16.6195
COLO 678 GDSC1; CTRP2 9.3775 21.3995 0.9359 14.5753
OUMS-23 CTRP2 9.4787 20.8921 1.2511 13.4255
HCT 8 CTRP2 10.4079 20.9707 1.8288 10.2913
SW620 GDSC1; CTRP2 13.8775 30.6335 -0.4974 13.0686
⏷ Show the Full List of 56 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1 -1.1548 6.1667 -2.9177 46.7203
Cancer Drug Sensitivity Data Curated from 25 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-182 CTRP2 -1.9404 6.9226 -2.9244 52.334
Li-7 CTRP2 0.2631 6.1204 -0.2859 39.89
JHH-7 GDSC1 0.983 5.2798 0.0709 31.3001
Huh-7 GDSC1 1.6765 5.3443 0.2637 18.8823
HLE GDSC1 1.934 5.2253 1.0754 21.1403
JHH-5 CTRP2 2.0665 6.7496 1.492 28.4637
SNU-878 CTRP2 2.1186 9.3185 0.5712 31.1825
SNU-886 CTRP2 2.1984 6.4655 1.725 27.2541
HuH-6 CTRP2 2.2483 8.5903 1.0079 29.4715
SNU-449 GDSC1; CTRP2 2.8724 8.8932 1.5361 25.8796
SNU-761 CTRP2 2.9868 10.4479 0.9668 27.4251
SNU-423 GDSC1; CTRP2 3.3843 14.9824 -0.7975 31.1062
JHH-2 GDSC1; CTRP2 3.6517 11.1672 1.2918 24.5686
Hep-G2/C3A GDSC1 3.7438 5.6287 1.6804 1.9403
SNU-475 GDSC1; CTRP2 5.3149 15.2576 0.8166 22.1666
JHH-4 GDSC1; CTRP2 7.3386 15.8848 2.1567 13.6185
JHH-6 GDSC1; CTRP2 7.3861 8.1537 5.7985 0.0494
Hep 3B2.1-7 GDSC1; CTRP2 7.4088 12.0247 4.1008 5.8757
HuH-1 GDSC1; CTRP2 7.8991 12.7752 4.0707 5.3174
PLC/PRF/5 CTRP2 8.3913 11.9405 4.7461 2.2615
SK-HEP-1 GDSC1; CTRP2 8.4677 13.2278 4.2149 4.0759
HLF CTRP2 9.5193 19.9187 1.7458 11.7311
JHH-1 GDSC1; CTRP2 10.0407 20.1787 1.9656 10.2958
SNU-398 GDSC1; CTRP2 10.1322 22.685 0.8349 13.829
SNU-387 GDSC1; CTRP2 10.3788 29.372 -2.2341 21.4329
⏷ Show the Full List of 25 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 211 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H1048 GDSC1 -2.3747 1.4414 -2.5889 57.4392
IST-SL2 GDSC1 -2.3375 5.0129 -3.6753 54.6314
NCI-H64 GDSC1 -2.1693 -0.6452 -2.1713 56.5227
NCI-H1648 GDSC1 -1.911 2.1158 -2.2374 52.6613
COR-L311 GDSC1 -1.3604 2.7394 -1.8106 47.2021
NCI-H1975 GDSC1; CTRP2 -1.0036 4.7262 -1.3316 47.2804
NCI-H520 GDSC1; CTRP2 -0.9418 7.2367 -1.9359 47.3573
NCI-H1437 GDSC1 -0.8726 3.2935 -1.4616 42.4849
SBC-3 GDSC1 -0.8512 3.2702 -1.4304 42.2356
COR-L303 GDSC1 -0.8043 3.5107 -1.4652 41.9777
EBC-1 GDSC1; CTRP2 -0.7083 4.0858 -0.8975 45.3049
NCI-H2795 GDSC1 -0.6686 6.2032 -2.0438 46.748
NCI-H596 GDSC1 -0.389 4.1513 -1.2675 38.429
EPLC-272H GDSC1; CTRP2 -0.3203 7.3613 -1.3012 44.0124
NCI-H1341 CTRP2 -0.3022 3.367 -0.3753 42.4661
SK-MES-1 GDSC1; CTRP2 -0.2766 5.3306 -0.6729 42.9272
Lu-99A GDSC1 -0.2766 4.5082 -0.9735 42.569
Calu-3 GDSC1; CTRP2 -0.1376 4.857 -0.4191 41.8435
PaCa-3 GDSC1 -0.0214 4.9109 -1.2039 35.8686
NCI-H1304 GDSC1 0.0113 5.2776 -1.3325 36.1671
NCI-H1703 GDSC1; CTRP2 0.1148 11.417 -2.4032 43.4943
NCI-H292 GDSC1; CTRP2 0.1233 5.3362 -0.2387 40.3599
DV-90 CTRP2 0.1347 7.4423 -0.8345 41.443
LC-2/ad GDSC1 0.1517 5.7712 -1.4143 35.6638
LB647-SCLC GDSC1 0.1864 5.3266 -1.1771 34.5438
ABC-1 GDSC1 0.1994 5.181 -1.0983 34.1395
DMS 454 CTRP2 0.2247 4.651 0.0121 39.3592
NCI-H1573 GDSC1; CTRP2 0.3527 14.9696 -3.7401 43.8546
LCLC-97TM1 GDSC1; CTRP2 0.3669 8.5408 -0.976 40.7603
LXF 289 GDSC1; CTRP2 0.395 7.6241 -0.6147 40.0192
COR-L23 GDSC1 0.475 4.4135 -0.4764 29.515
NCI-H1944 GDSC1; CTRP2 0.4826 5.4596 0.1237 38.0651
LC-1/sq GDSC1 0.587 6.6532 -0.9319 37.2991
NCI-H3255 GDSC1 0.5874 5.6474 -0.4965 35.8324
NCI-H446 GDSC1; CTRP2 0.6235 7.8215 -0.4371 38.7939
A-427 GDSC1 0.6395 6.3623 -0.7498 36.4375
NCI-H2135 GDSC1 0.8075 5.0335 -0.4209 27.4154
NCI-H211 GDSC1; CTRP2 0.8084 9.0375 -0.6955 38.6213
NCI-H1876 GDSC1 0.8461 7.9871 -1.7992 33.5121
NCI-H3122 GDSC1 0.8708 5.215 -0.4431 27.2189
COR-L88 GDSC1; CTRP2 0.8866 41.9908 -16.3895 46.9084
NCI-H1693 GDSC1 0.9353 10.5591 -2.9823 36.5407
Ms-1 GDSC1 0.9624 6.8942 -1.1582 30.4127
NCI-H2869 GDSC1 0.973 6.2548 -0.8389 28.8417
NCI-H1184 CTRP2 0.9801 9.5594 -0.7228 38.0642
NCI-H1993 GDSC1 0.9914 8.5115 -1.9216 33.2768
NCI-H1568 GDSC1; CTRP2 1.0112 7.1921 0.2002 35.8949
DMS 273 GDSC1; CTRP2 1.0617 9.7271 -0.7056 37.747
NCI-H1792 GDSC1; CTRP2 1.0953 5.2275 0.8424 33.783
EMC-BAC-2 GDSC1 1.1299 5.5602 -0.3552 25.4204
NCI-H647 GDSC1; CTRP2 1.1645 9.1273 -0.3536 36.6615
COLO 699 CTRP2 1.1747 11.8867 -1.5161 38.8038
NCI-H2227 GDSC1 1.2434 8.1164 -1.4969 30.5709
SBC-1 GDSC1 1.2548 6.2414 -0.5664 26.0483
NCI-H2228 GDSC1; CTRP2 1.2966 7.3119 0.4688 34.1712
NCI-H2141 GDSC1 1.3093 5.7265 -0.2649 24.0248
IST-SL1 GDSC1 1.3636 7.75 -1.2069 28.792
EMC-BAC-1 GDSC1 1.3949 3.2645 0.9707 14.9914
NCI-H1755 GDSC1; CTRP2 1.4419 23.3662 -6.6983 43.0944
NCI-H2030 GDSC1; CTRP2 1.4488 8.8043 0.0763 34.6818
HCC44 GDSC1; CTRP2 1.4758 7.3207 0.6598 33.0161
NCI-H69 GDSC1; CTRP2 1.5229 9.4642 -0.1129 34.8961
Lu-139 GDSC1 1.5407 5.571 0.0272 21.0986
COR-L321 GDSC1 1.5496 8.5185 -1.4205 28.9355
Lu-134-A GDSC1 1.5534 5.8239 -0.085 21.7799
RERF-LC-KJ GDSC1 1.5657 9.0495 -1.6701 29.8961
NCI-H1563 GDSC1; CTRP2 1.5807 14.3006 -2.2109 38.618
NCI-H358 GDSC1; CTRP2 1.6491 10.3676 -0.3634 35.0658
NCI-H1666 GDSC1; CTRP2 1.6799 10.4098 -0.3499 34.9361
NCI-H2110 GDSC1; CTRP2 1.6995 6.8726 1.0532 31.0782
DMS 53 GDSC1; CTRP2 1.723 6.8691 1.0798 30.9169
NCI-H1385 CTRP2 1.7511 6.6781 1.1718 30.5315
NCI-H2731 GDSC1 1.7779 10.3142 -2.1144 30.7053
Lu-99 CTRP2 1.7827 7.5014 0.9276 31.1967
NCI-H2347 GDSC1 1.8146 8.3572 -1.1068 26.4147
NCI-H1694 GDSC1; CTRP2 1.8343 7.6109 0.9436 30.9798
DMS 114 GDSC1; CTRP2 1.9244 8.1044 0.8556 30.9584
NCI-H2171 GDSC1 1.9616 7.9769 -0.7895 24.2116
NCI-H196 GDSC1; CTRP2 2.0587 11.7897 -0.5768 34.2677
NCI-H847 GDSC1 2.0834 5.309 0.6467 14.4083
NCI-H1355 GDSC1; CTRP2 2.1023 10.3298 0.1199 32.465
NCI-H2196 GDSC1; CTRP2 2.2037 8.96 0.8097 30.218
NCI-H1436 GDSC1 2.2536 8.3749 -0.7391 22.7972
NCI-H1793 GDSC1; CTRP2 2.2766 9.6723 0.585 30.6564
RERF-LC-Sq1 GDSC1 2.2935 8.7827 -0.9095 23.5525
HCC2935 CTRP2 2.3938 9.0648 0.965 29.161
UMC-11 GDSC1 2.4081 5.5619 1.3896 17.1171
NCI-H810 GDSC1; CTRP2 2.4369 8.3264 1.3134 27.9135
NCI-H322M GDSC1 2.4377 9.0069 -0.9015 22.9747
NCI-H2804 GDSC1 2.4407 11.0157 -1.9034 27.4996
A-549 GDSC1; CTRP2 2.4549 8.6887 1.1854 28.2772
HOP-92 GDSC1; CTRP2 2.4979 12.4952 -0.4638 32.7239
NCI-H2803 GDSC1 2.521 6.3858 0.477 14.0227
RERF-LC-A1 CTRP2 2.5334 9.4244 0.9573 28.7661
HARA [Human squamous cell lung carcinoma] GDSC1; CTRP2 2.562 10.2656 0.6186 29.7035
NCI-H2170 GDSC1; CTRP2 2.5793 6.9481 1.9825 25.1819
NCI-H1688 GDSC1 2.6341 6.6785 1.0606 18.3516
NCI-H290 GDSC1 2.7422 10.0286 -1.1633 23.2089
NCI-H1781 GDSC1 2.7571 10.8308 -1.5518 24.9529
HOP-62 GDSC1; CTRP2 2.7669 12.5593 -0.229 31.3999
NCI-H1581 GDSC1; CTRP2 2.7727 8.8167 1.4648 26.4112
NCI-H513 GDSC1 2.7859 10.0561 -1.1418 22.9534
NCI-H1836 GDSC1 2.831 7.7808 0.0287 16.0596
LUDLU-1 CTRP2 2.8898 7.3443 2.1761 23.563
HCC4006 CTRP2 2.9626 8.6452 1.735 24.9308
NCI-H2085 GDSC1; CTRP2 2.9642 21.9303 -4.5919 38.1506
NCI-H2081 GDSC1; CTRP2 2.9891 13.382 -0.4025 31.2144
LK-2 GDSC1 3.0136 7.6917 0.2145 14.2017
NCI-H82 GDSC1 3.0166 6.882 0.6173 11.3402
NCI-H209 GDSC1 3.0503 7.0655 0.552 11.7091
CPC-N GDSC1 3.1565 8.5045 -0.0791 15.6882
NCI-H748 GDSC1 3.1777 9.0655 -0.3409 17.2518
COR-L105 GDSC1; CTRP2 3.3376 11.0971 1.0168 26.3004
NCI-H2172 GDSC1 3.3637 8.9188 -0.1281 15.3482
NCI-H841 GDSC1; CTRP2 3.4064 9.3797 1.8728 23.2042
NCI-H1770 GDSC1 3.4466 7.1107 0.8148 8.6389
NCI-H345 GDSC1 3.4501 4.3463 2.0597 0.3374
Lu-165 GDSC1 3.4593 11.5695 -1.3666 21.8395
HCC33 GDSC1 3.4654 9.3877 -0.2834 16.0002
NCI-H2369 GDSC1 3.6137 7.965 0.518 10.296
COLO 668 GDSC1; CTRP2 3.6368 9.7346 1.9446 22.3265
NCI-H2818 GDSC1 3.6373 10.9243 -0.1963 21.8348
NCI-H1155 GDSC1; CTRP2 3.6988 10.9264 1.4513 23.9064
NCI-H510A GDSC1 3.7856 5.9266 1.5744 2.5269
NCI-H1838 GDSC1; CTRP2 3.8454 9.9671 2.0449 21.4141
NCI-H838 GDSC1; CTRP2 3.9193 11.357 1.4606 23.3078
Lu-65 GDSC1; CTRP2 3.9565 13.6385 0.3925 26.5964
NCI-H720 GDSC1 3.9882 5.4274 1.8756 0.651
NCI-H2595 GDSC1 4.0118 9.1112 0.2389 11.119
Lu-135 GDSC1 4.0204 7.9218 0.8078 7.2398
NCI-H522 GDSC1; CTRP2 4.1089 10.0987 2.2422 20.0075
T3M-10 CTRP2 4.1649 12.1075 1.3326 23.1298
EKVX GDSC1; CTRP2 4.2651 13.9553 0.5232 25.459
NCI-H2373 GDSC1 4.2717 7.3141 1.2329 3.8585
HCC1438 CTRP2 4.3027 13.3002 0.8793 24.2763
NCI-H2444 GDSC1; CTRP2 4.3757 9.1773 2.9365 16.654
HCC15 GDSC1; CTRP2 4.4175 13.0228 1.1213 23.2216
NCI-H1650 GDSC1; CTRP2 4.4175 14.1624 0.5609 24.983
ChaGo-K-1 GDSC1; CTRP2 4.4426 11.6315 1.8248 20.7321
NCI-H1395 CTRP2 4.4694 10.8222 2.2428 19.1197
NCI-H2722 GDSC1 4.6555 11.1573 -0.3073 12.8703
NCI-H2591 GDSC1 4.6778 12.0939 -0.7401 15.2444
NCI-H23 GDSC1; CTRP2 4.9102 23.8865 -3.8386 33.2671
NCI-H187 GDSC1 5.0262 13.3673 -1.1146 16.3074
NCI-H2461 GDSC1 5.1102 11.7423 -0.2883 11.6819
NCI-H322 CTRP2 5.1256 7.9569 4.2452 9.5453
NCI-H526 GDSC1; CTRP2 5.1966 15.7334 0.4764 23.4689
HCC2279 CTRP2 5.2035 18.1281 -0.7117 26.6899
SW1271 GDSC1; CTRP2 5.2728 14.898 0.9592 21.8024
NCI-H441 GDSC1 5.3194 12.9897 -0.7404 13.6955
DMS 79 GDSC1; CTRP2 5.3363 15.536 0.6963 22.4966
COR-L95 GDSC1; CTRP2 5.3704 13.6696 1.6565 19.2283
NCI-H1869 GDSC1; CTRP2 5.4086 16.7473 0.1543 23.9551
NCI-H2087 GDSC1; CTRP2 5.4583 20.5281 -1.6915 28.4026
NCI-H1623 GDSC1; CTRP2 5.4871 14.6182 1.2847 20.2673
NCI-H1105 CTRP2 5.537 12.2012 2.5336 15.598
RERF-LC-MS GDSC1; CTRP2 5.6332 15.6522 0.8937 21.2453
NCI-H1915 GDSC1; CTRP2 5.6362 10.8461 3.2954 12.3345
NCI-H2009 GDSC1; CTRP2 5.7401 13.2371 2.1914 16.489
NCI-H524 GDSC1; CTRP2 5.8426 24.1908 -3.1976 30.5148
NCI-H1734 GDSC1; CTRP2 5.8898 17.3869 0.2438 22.7009
HCC1171 CTRP2 5.8998 19.6314 -0.8699 25.6536
KNS-62 CTRP2 5.9053 15.1456 1.3774 19.083
NCI-H1092 GDSC1; CTRP2 6.2564 17.1593 0.6626 20.7121
HCC827 GDSC1; CTRP2 6.2661 16.4995 1.0004 19.6207
NCI-H2106 CTRP2 6.2715 13.8575 2.3254 14.9225
SBC-5 GDSC1; CTRP2 6.4401 15.0347 1.8746 16.2756
LK2 CTRP2 6.6316 10.9511 4.0616 7.2631
SW1573 GDSC1; CTRP2 6.8389 24.617 -2.5884 27.634
HCC366 CTRP2 6.8791 18.2426 0.6262 19.6409
PC-14 GDSC1; CTRP2 7.1057 14.9671 2.4337 12.9824
NCI-H1339 CTRP2 7.1562 14.8179 2.5463 12.4658
HCC1195 CTRP2 7.1678 20.5712 -0.3053 21.811
Sq-1 CTRP2 7.2136 22.0437 -1.003 23.5264
RERF-LC-Ad1 CTRP2 7.2615 8.3484 5.6808 0.2701
MOR/CPR CTRP2 7.286 8.0741 5.7902 0.0738
BEN GDSC1; CTRP2 7.6116 8.5021 5.7593 0.0559
NCI-H661 GDSC1; CTRP2 7.6555 23.0569 -1.1593 23.1416
NCI-H2029 GDSC1; CTRP2 7.7569 15.2555 2.7763 10.5946
IA-LM GDSC1; CTRP2 7.8212 16.4511 2.2374 12.5202
CAL-12T GDSC1; CTRP2 7.8262 22.4676 -0.7337 21.7962
HCC95 CTRP2 7.8709 18.8793 1.0783 16.4642
NCI-H2405 GDSC1; CTRP2 7.9038 21.9673 -0.4255 20.8596
NCI-H2122 GDSC1; CTRP2 7.9066 9.4702 5.5256 0.3342
NCI-H1435 GDSC1; CTRP2 7.9437 22.0431 -0.4325 20.8114
NCI-H460 GDSC1; CTRP2 8.0318 16.2446 2.4907 11.2478
NCI-H2291 GDSC1; CTRP2 8.0319 15.5979 2.8056 10.059
NCI-H226 GDSC1; CTRP2 8.1322 14.9824 3.1729 8.4993
VMRC-LCD CTRP2 8.4123 15.9105 2.918 9.0735
LOU-NH91 GDSC1; CTRP2 8.476 16.8862 2.4918 10.5748
NCI-H2342 GDSC1; CTRP2 8.9497 26.191 -1.722 22.3727
NCI-H1651 GDSC1; CTRP2 9.0191 21.959 0.4094 16.716
RERF-LC-Ad2 CTRP2 9.1366 28.27 -2.6084 23.9844
HCC1833 CTRP2 9.2661 34.1351 -5.4147 28.5654
HCC1588 CTRP2 9.3305 19.748 1.7 12.1486
LC-1/sq-SF CTRP2 9.3647 18.9018 2.1278 10.6287
NCI-H727 GDSC1; CTRP2 9.4309 17.538 2.8152 8.0926
HCC78 GDSC1; CTRP2 9.5545 20.4296 1.525 12.4218
NCI-H889 CTRP2 10.311 43.2517 -9.1341 31.6491
NCI-H2023 GDSC1; CTRP2 10.4011 22.1449 1.2711 12.1102
Calu-1 CTRP2 10.431 26.0378 -0.5746 17.4217
NCI-H1299 GDSC1; CTRP2 10.6988 22.9183 1.0995 12.267
HCC2108 CTRP2 10.977 25.9638 -0.1649 15.5963
LCLC-103H GDSC1; CTRP2 11.0005 22.5157 1.4816 10.6929
SK-LU-1 GDSC1; CTRP2 11.0948 24.1115 0.7933 12.7022
Calu-6 GDSC1; CTRP2 11.6989 22.0606 2.1135 7.8883
NCI-H2126 CTRP2 11.7812 25.6247 0.5224 12.6617
NCI-H650 GDSC1; CTRP2 11.8875 28.3729 -0.7062 15.8702
SHP-77 GDSC1; CTRP2 12.3234 24.8916 1.1971 10.0606
NCI-H1373 CTRP2 12.3409 25.7341 0.8209 11.1518
Hs 888.Lu CTRP2 4.9854 11.7321 2.276 17.7934
⏷ Show the Full List of 211 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1 -1.188 7.7311 -3.6528 47.4015
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Yamato-SS CTRP2 0.3482 9.0415 -1.1868 41.1633
Aska-SS CTRP2 0.691 8.7807 -0.7206 39.0962
EW-8 GDSC1 -1.3478 1.9879 -1.5918 46.7977
A-204 GDSC1; CTRP2 -1.0273 7.6665 -2.17 47.8669
G-401 GDSC1; CTRP2 -0.3971 8.9957 -1.9654 45.015
Rh18 GDSC1; CTRP2 0.0221 14.1788 -3.7125 44.8358
STS-0421 GDSC1 0.9443 5.0567 -0.2967 25.9844
Hs 633.T GDSC1 1.7841 7.9744 -0.9429 25.7312
Rh41 GDSC1; CTRP2 1.8078 4.337 1.7511 28.4153
G-402 GDSC1; CTRP2 2.096 11.3428 -0.3368 33.6097
MFH-ino GDSC1 2.1179 7.3552 -0.3446 21.0523
KYM-1 GDSC1; CTRP2 3.1126 10.3702 1.1287 26.5575
SW684 GDSC1 3.2096 6.5334 0.929 8.4609
SW872 GDSC1 3.4639 10.7505 -0.9574 19.8076
TE 441.T GDSC1; CTRP2 3.5252 9.6475 1.8723 22.8856
Hs 729.T CTRP2 3.534 9.4556 1.9681 22.5152
Rh30 GDSC1 3.6806 9.0045 0.0606 13.1947
TE 617.T CTRP2 4.1391 8.0432 3.2126 16.1699
MES-SA GDSC1; CTRP2 4.166 11.7783 1.4932 22.5778
VA-ES-BJ GDSC1 4.2355 11.2722 -0.6493 15.9104
GCT GDSC1; CTRP2 4.7418 11.919 1.9617 19.5275
HT-1080 GDSC1; CTRP2 5.7458 12.3091 2.6598 14.6696
SK-LMS-1 GDSC1; CTRP2 6.5252 16.4399 1.2417 18.3231
Tm87-16 CTRP2 6.859 20.7051 -0.6187 23.1978
TTC-709 CTRP2 6.9428 18.6383 0.4796 19.9716
BT-12 CTRP2 6.9738 7.8307 5.7565 0.2292
SK-UT-1 GDSC1; CTRP2 7.4659 18.4738 0.9709 17.5017
SW982 GDSC1; CTRP2 7.6203 16.4296 2.0995 13.3539
BT-16 CTRP2 7.6245 15.495 2.5626 11.6221
RD GDSC1; CTRP2 7.7518 19.8293 0.518 18.4264
RKN GDSC1; CTRP2 7.8723 9.3622 5.5519 0.2951
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 44 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
2004 CTRP2 0.4642 13.1282 -2.7926 42.7055
A2780 GDSC1; CTRP2 -1.2895 5.5493 -1.8298 49.0475
IGROV-1 GDSC1; CTRP2 -0.741 4.6762 -1.037 45.6466
Caov-4 GDSC1 -0.3467 7.0734 -2.5113 41.4576
OC 314 GDSC1; CTRP2 0.5638 3.5292 0.518 36.6586
SNU-840 CTRP2 0.9835 10.6216 -1.1621 38.8507
OVTOKO GDSC1; CTRP2 1.1091 10.1923 -0.8496 37.8618
ONCO-DG-1 CTRP2 1.9852 10.3244 0.0019 33.1291
SNU-119 CTRP2 2.5357 14.3378 -1.2957 34.3917
OVISE GDSC1; CTRP2 2.6466 10.5078 0.5962 29.5214
OVCAR-4 GDSC1; CTRP2 2.6939 9.437 1.1178 27.786
OVCAR-5 GDSC1; CTRP2 2.8096 11.6691 0.2287 30.09
ES-2 GDSC1 3.0525 5.2183 1.4556 4.9397
COV644 CTRP2 3.4172 17.593 -2.0429 33.5452
EFO-21 GDSC1; CTRP2 3.4977 11.3897 1.0365 25.8095
OVKATE GDSC1 3.6387 13.0007 -1.9387 23.7906
EFO-27 GDSC1; CTRP2 4.2816 9.7422 2.579 18.2884
OV7 CTRP2 4.3781 15.6412 -0.2047 27.2317
Kuramochi GDSC1; CTRP2 4.4874 16.7996 -0.6802 28.1827
OAW42 GDSC1; CTRP2 4.4965 8.8004 3.2315 15.1815
OVCAR-3 GDSC1 4.5022 13.6727 -1.6286 20.0572
COV362 CTRP2 4.5994 10.6246 2.4613 17.9742
OAW28 GDSC1; CTRP2 4.6237 18.3263 -1.3172 29.3462
TOV-112D GDSC1; CTRP2 4.6701 11.9033 1.9034 19.9082
Caov-3 GDSC1; CTRP2 4.7816 17.9109 -0.9715 28.2206
DOV13 GDSC1; CTRP2 4.7987 10.914 2.5069 17.3307
COV434 CTRP2 5.674 15.8147 0.8472 21.3084
JHOS-2 GDSC1; CTRP2 5.8462 16.9122 0.4444 22.1971
JHOM-1 CTRP2 5.8912 16.7546 0.5611 21.753
TYK-nu GDSC1; CTRP2 6.383 11.9211 3.3832 10.5114
OVK18 GDSC1; CTRP2 6.405 17.9003 0.4142 21.1797
SNU-8 CTRP2 6.6338 18.6141 0.2437 21.2476
TOV-21G GDSC1; CTRP2 7.5534 8.8579 5.6099 0.2998
OV56 GDSC1; CTRP2 7.8209 9.0886 5.6314 0.1728
FU-OV-1 GDSC1; CTRP2 8.3493 25.3726 -1.7725 23.4216
OV-90 GDSC1; CTRP2 8.467 10.1203 5.508 0.1964
ES2 CTRP2 8.5387 14.2567 3.7841 5.607
OVCAR-8 GDSC1; CTRP2 8.5921 19.3677 1.3681 14.3523
RMG-I GDSC1; CTRP2 8.9762 28.2717 -2.7305 24.4672
MCAS CTRP2 9.7233 19.3909 2.1316 10.1376
OVSAHO CTRP2 11.0118 27.4912 -0.8747 17.4124
SK-OV-3 GDSC1; CTRP2 12.3498 27.1998 0.1462 13.0548
JHOC-5 CTRP2 14.3696 26.5569 1.6136 6.8902
HEY A8 CTRP2 14.9189 33.5542 -1.2066 13.7242
⏷ Show the Full List of 44 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Clivus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U-CH1 CTRP2 5.2635 13.5331 1.6309 19.5503
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Thigh Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
H-STS CTRP2 7.709 14.4955 3.113 9.3634
SYO-1 CTRP2 11.8341 28.201 -0.6598 15.8173
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H28 GDSC1; CTRP2 3.1537 9.3632 1.6224 24.7851
MPP 89 GDSC1 4.458 12.5923 -1.1336 17.8519
MSTO-211H GDSC1; CTRP2 4.6654 15.1276 0.3079 25.1513
NCI-H2452 GDSC1; CTRP2 4.9104 11.8349 2.1572 18.4129
IST-Mes1 GDSC1; CTRP2 6.2081 16.1099 1.1474 19.252
ACC-MESO-1 CTRP2 9.2947 24.7835 -0.7737 19.5666
JL-1 CTRP2 9.9689 19.1954 2.3809 8.9613
NCI-H2052 GDSC1; CTRP2 10.6062 23.1246 0.9413 12.8741
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LNCaP clone FGC GDSC1; CTRP2 -0.4346 4.0886 -0.6043 43.5251
22Rv1 GDSC1; CTRP2 -0.4057 6.4772 -1.1176 44.1622
VCaP GDSC1; CTRP2 -0.3346 4.875 -0.6363 43.1254
PC-3 GDSC1 -0.2902 5.5005 -1.7388 39.3024
PaCa-3 CTRP2 3.6698 9.4211 2.1207 21.5937
DU145 GDSC1; CTRP2 5.4326 12.0495 2.5179 15.8803
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1; CTRP2 5.8502 12.114 2.8462 13.7178
YD-15 CTRP2 5.9716 14.6277 1.6919 17.8506
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1 -1.4858 4.6471 -2.6267 48.7853
Cancer Drug Sensitivity Data Curated from 42 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HGC-27 GDSC1; CTRP2 -1.8689 2.8306 -1.9721 52.5604
RF-48 GDSC1 -1.3207 6.2361 -3.1185 47.8854
23132/87 GDSC1; CTRP2 -0.398 8.2175 -1.6802 44.7544
SNU-216 CTRP2 -0.134 5.1054 -0.467 41.9227
NCC-StC-K140 CTRP2 1.0111 3.7529 0.9677 33.6755
MKN1 GDSC1; CTRP2 1.7215 8.4805 0.4936 32.67
ECC10 GDSC1; CTRP2 1.9032 5.9286 1.5561 28.7681
IM95 GDSC1; CTRP2 1.9556 8.554 0.713 31.2845
SNU-601 CTRP2 2.0637 9.6781 0.3618 31.9398
NCI-N87 GDSC1; CTRP2 2.1417 10.522 0.0758 32.4577
HSC-39 GDSC1 2.4628 7.2162 0.0144 17.4555
RERF-GC-1B GDSC1 2.5321 6.7487 0.3047 15.2166
SNU-5 GDSC1; CTRP2 2.6041 7.4777 1.82 25.6813
SNU-16 GDSC1; CTRP2 2.7563 3.7807 2.7555 21.9086
TMK-1 GDSC1 2.9219 5.8466 1.057 8.3433
OCUM-1 GDSC1 3.1834 5.9491 1.1936 6.556
SCH GDSC1 3.3814 7.1245 0.7629 9.1962
HuG1-N CTRP2 3.4472 12.0893 0.6558 27.1243
SNU-1 GDSC1; CTRP2 3.5261 12.8893 0.3491 27.8138
NUGC-4 GDSC1; CTRP2 3.5653 15.0365 -0.6543 30.3182
GCIY GDSC1 3.7574 5.9316 1.5569 2.6864
TGBC11TKB GDSC1 3.7897 6.1479 1.4797 3.13
Hs 746.T GDSC1; CTRP2 4.169 6.7069 3.785 13.8789
GSS CTRP2 4.2159 11.9238 1.4699 22.5358
MKN28 GDSC1 4.4171 10.7369 -0.266 13.2276
MKN7 GDSC1; CTRP2 5.8042 13.5383 2.0954 16.7181
LMSU CTRP2 6.1614 17.0232 0.6522 20.9313
GSU CTRP2 7.0664 7.6376 5.8617 0.0336
KE-39 CTRP2 7.1785 19.9908 -0.0076 20.9685
SNU-668 CTRP2 7.3118 17.2904 1.4396 16.2151
Fu97 GDSC1; CTRP2 7.5375 25.0055 -2.2223 25.7121
MKN45 GDSC1; CTRP2 7.6505 8.679 5.7124 0.0993
SNU-620 CTRP2 7.9512 14.9935 3.0421 9.2713
ECC12 CTRP2 8.3311 17.9247 1.8853 12.9832
SNU-719 CTRP2 8.5865 22.9847 -0.4118 19.7096
MKN74 CTRP2 8.8211 19.9067 1.2689 14.3305
SH-10-TC CTRP2 9.4446 18.4424 2.3985 9.5679
NUGC-3 GDSC1; CTRP2 10.8122 26.4268 -0.4991 16.7091
AGS GDSC1; CTRP2 11.28 22.123 1.8361 9.233
SNG-M GDSC1; CTRP2 1.0154 12.2119 -1.823 39.7798
SNU-685 CTRP2 10.1941 18.2559 2.9523 6.705
SNU-1077 CTRP2 10.7397 21.2442 1.91 9.6193
⏷ Show the Full List of 42 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 18 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
K5 GDSC1 -0.0655 5.958 -1.7174 37.9178
IHH-4 GDSC1 0.2425 4.97 -0.5871 38.1444
HTC-C3 GDSC1 0.4555 7.0979 -1.7389 35.1911
ASH-3 GDSC1 0.546 5.016 -0.2822 35.2365
KMH-2 GDSC1 0.5886 5.2258 -0.3212 35.1528
BHT-101 GDSC1; CTRP2 1.7394 8.3127 0.578 32.3733
SW579 CTRP2 2.0877 8.2249 0.9831 30.0486
CAL-62 GDSC1; CTRP2 2.2245 8.2375 1.1236 29.1793
WRO GDSC1 3.1364 5.7275 1.2681 6.1245
ML-1 [Human leukemia] GDSC1; CTRP2 3.9342 12.2788 1.0317 24.6976
8505C GDSC1; CTRP2 4.3158 12.6469 1.2113 23.1683
8305C GDSC1; CTRP2 4.8949 16.6474 -0.2431 26.1599
TT2609-C02 GDSC1; CTRP2 6.4152 15.4342 1.6548 17.1101
CGTH-W-1 GDSC1; CTRP2 6.4747 16.1871 1.3271 18.1315
FTC-133 GDSC1; CTRP2 7.3679 12.8793 3.6573 7.7244
FTC-238 CTRP2 8.2011 17.3656 2.065 12.5455
TT GDSC1; CTRP2 9.3585 21.1825 1.0277 14.3132
B-CPAP GDSC1; CTRP2 10.5022 23.1195 0.8751 13.2125
⏷ Show the Full List of 18 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 54 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H3118 GDSC1 -1.0197 3.7703 -1.5386 48.9314
OSC-20 GDSC1 -0.4331 4.8293 -1.2578 44.2153
UPCI-SCC-090 GDSC1 -0.2345 5.1622 -1.5328 38.3385
SCC-15 GDSC1 -0.2341 4.0693 -0.7776 41.7873
CAL-33 GDSC1; CTRP2 -0.0536 2.7388 -0.0744 40.6875
BB30-HNC GDSC1 -0.0386 4.0132 -0.8417 34.4185
SCC-25 GDSC1; CTRP2 0.0505 7.508 -0.948 41.9681
DOK GDSC1 0.0804 8.2885 -2.669 39.5903
LB771-HNC GDSC1 0.5016 5.5342 -0.9565 31.8284
JHU-011 GDSC1 0.8011 4.9377 -0.3829 27.2281
PCI-04B GDSC1 0.9841 4.7698 -0.1236 24.7127
PCI-15A GDSC1 1.5008 5.6369 -0.0421 21.7353
BICR 56 CTRP2 1.5857 10.4136 -0.4488 35.4606
SAT [Human HNSCC] GDSC1 1.6106 9.5405 -1.8748 30.4975
PCI-06A GDSC1 1.6917 6.349 -0.2178 22.0224
SAS GDSC1 1.9281 6.9805 -0.3218 21.6746
HO-1-u-1 GDSC1 2.3415 4.9951 1.5899 16.0708
JHU-022 GDSC1 2.414 10.7778 -1.8065 27.2108
YD-10B CTRP2 2.4211 12.2461 -0.4241 32.8521
BICR 10 GDSC1 2.6046 6.4046 0.535 13.305
Detroit 562 GDSC1 2.6721 6.5211 0.5307 13.1033
YD-8 CTRP2 2.8216 9.4119 1.2603 26.9519
HSC-2 GDSC1; CTRP2 2.8762 6.732 2.3773 22.8729
OSC-19 GDSC1 2.9458 11.326 -1.6474 24.7354
PE/CA-PJ49 CTRP2 3.0119 8.244 1.9535 24.0137
PE/CA-PJ15 GDSC1; CTRP2 3.0222 8.9263 1.6775 24.9627
SCC-4 GDSC1; CTRP2 3.0864 8.0695 2.1031 23.26
SNU-1076 CTRP2 3.2572 12.6878 0.1872 28.9744
PE/CA-PJ34 (clone C12) CTRP2 3.2998 6.9371 2.7653 20.2018
Ca9-22 GDSC1 3.3744 8.4651 0.1032 13.8189
BB49-HNC GDSC1 3.3904 9.9604 -0.6222 18.2209
BICR 78 GDSC1 3.4998 9.7033 -0.4133 16.6756
HO-1-N-1 GDSC1 3.5009 8.5736 0.1421 13.1822
KON GDSC1 3.599 6.5082 1.2019 5.4482
PCI-38 GDSC1 3.7508 8.3273 0.4377 10.478
SKN-3 GDSC1 3.8923 10.3201 -0.4296 15.6143
PE/CA-PJ41 (clone D2) CTRP2 3.9028 10.466 1.8677 21.9138
BHY GDSC1; CTRP2 4.2266 15.5019 -0.2733 27.7665
BICR 31 GDSC1; CTRP2 4.4616 12.5586 1.3896 22.2176
PCI-30 GDSC1 4.5575 10.8442 0.56 15.1705
HSC-4 GDSC1; CTRP2 4.9717 10.5943 2.8236 15.6881
BICR 22 GDSC1; CTRP2 5.3786 11.8794 2.555 15.8508
SNU-46 CTRP2 5.5662 19.8872 -1.2794 27.2836
SNU-1214 CTRP2 6.134 15.6418 1.3201 18.8189
SCC-9 GDSC1; CTRP2 6.4104 18.6818 0.0281 22.2926
BICR 18 CTRP2 6.4606 15.0571 1.88 16.2169
FaDu GDSC1; CTRP2 6.5347 13.3037 2.8149 12.524
BICR 6 CTRP2 6.6446 12.9701 3.0682 11.3142
BICR 16 CTRP2 7.3422 19.5643 0.3333 19.6907
HSC-3 GDSC1; CTRP2 7.6864 9.1091 5.5705 0.3287
SNU-899 CTRP2 9.2397 18.5523 2.2111 10.5063
CAL-27 GDSC1; CTRP2 9.8761 19.2031 2.3184 9.294
SNU-1066 CTRP2 10.7012 20.374 2.2883 8.4063
SNU-1041 CTRP2 12.7195 24.3616 1.6689 8.2317
⏷ Show the Full List of 54 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 25 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
253J CTRP2 -1.1718 1.8331 -1.1857 48.0914
U-BLC1 CTRP2 -0.9925 4.4654 -1.2689 47.1722
CAL-29 GDSC1; CTRP2 0.2499 4.2016 0.1119 39.001
RT-112 GDSC1; CTRP2 0.6184 5.2161 0.3267 37.0123
253J-BV CTRP2 0.8336 6.9666 0.0815 36.8413
BC-3C CTRP2 1.8741 5.4061 1.6503 28.5419
TCCSUP GDSC1; CTRP2 2.4342 9.4735 0.8335 29.4434
BFTC-905 GDSC1; CTRP2 2.5938 8.861 1.2593 27.6215
JMSU-1 CTRP2 2.6238 10.4817 0.5848 29.6211
UM-UC-1 CTRP2 2.8724 6.824 2.3423 23.0109
UM-UC-3 GDSC1; CTRP2 3.6709 14.8055 -0.4432 29.5453
HT-1197 GDSC1; CTRP2 4.001 10.3655 2.011 21.1406
5637 GDSC1; CTRP2 4.7469 18.4365 -1.2636 28.9596
KMBC-2 CTRP2 4.9043 11.7589 2.1891 18.3066
SW780 GDSC1 4.922 6.6517 1.7955 0.3708
VM-CUB-1 CTRP2 5.1314 12.8599 1.8488 19.0587
T24 GDSC1; CTRP2 6.5485 15.6596 1.6502 16.8727
J82 GDSC1; CTRP2 6.9945 17.9809 0.8483 18.7335
KU-19-19 GDSC1; CTRP2 7.5479 8.742 5.6508 0.2208
SW1710 GDSC1; CTRP2 7.8318 12.8679 3.9826 5.7529
639V GDSC1; CTRP2 7.8695 8.7995 5.7482 0.0375
HT-1376 GDSC1; CTRP2 8.3494 17.9709 1.8759 12.9879
SCaBER CTRP2 8.5971 19.473 1.3203 14.5032
647V GDSC1; CTRP2 9.7795 21.8304 1.0055 13.785
RT-4 GDSC1; CTRP2 9.9149 21.1895 1.4039 12.3263
⏷ Show the Full List of 25 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BPH-1 GDSC1 -2.5006 5.6554 -4.1046 55.2523
OVMIU GDSC1 -2.4208 1.7924 -2.7147 57.5257
PA-1 GDSC1 -2.4066 1.6292 -2.6627 57.5539
KGN GDSC1 -2.0947 2.9345 -2.6706 53.957
Ca Ski GDSC1 -2.0245 2.8504 -2.5682 53.4073
SW954 GDSC1 -1.1836 3.0753 -1.7247 45.5514
ME-180 GDSC1 -0.777 3.5686 -1.4568 41.7513
ACC-OV7 GDSC1 -0.1089 5.8294 -1.7025 38.1217
NCC-IT GDSC1 0.3501 6.8965 -1.7448 35.7492
OV17R GDSC1 0.3566 10.0926 -3.2831 39.5678
SKN GDSC1 0.5787 6.8196 -1.0145 37.5912
NT2-D1 GDSC1 0.5997 6.2844 -1.2121 32.4495
DSH1 GDSC1 0.9885 5.3316 -0.3828 26.2767
C-33 A GDSC1 1.0561 5.8035 -0.5426 26.8614
OMC-1 [Human cervical carcinoma] GDSC1 1.4212 6.1884 -0.3857 24.241
HEY GDSC1 1.735 6.1019 -0.0566 20.8054
PEO1 GDSC1 1.8496 11.343 -2.5661 31.9146
SW962 GDSC1 2.2212 9.2211 -1.1894 25.218
SiSo GDSC1 2.3068 7.333 -0.1735 19.2587
OVCA433 GDSC1 2.4626 8.4612 -0.6082 21.2873
JHOS-3 GDSC1 2.5566 8.3305 -0.4657 20.1211
JAR GDSC1 2.8125 11.3224 -1.7526 25.6209
LB831-BLC GDSC1 2.9733 8.6693 -0.302 17.6864
CAL-39 GDSC1 3.0418 8.5518 -0.1905 16.7679
NEC8 GDSC1 3.0722 5.2755 1.4415 4.9932
OVCA420 GDSC1 3.2029 7.0933 0.6508 10.5266
HT-3 GDSC1 3.2098 7.5777 0.4182 12.1694
HEC-1 GDSC1 3.3086 7.9231 0.321 12.5458
DoTc2 4510 GDSC1 3.3223 8.7766 -0.0888 15.2264
SiHa GDSC1 3.4255 8.0546 0.3415 12.0565
UWB1.289 GDSC1 3.5732 14.8728 -2.9191 27.4956
C-4-I GDSC1 3.6082 5.4761 1.6746 2.1936
MS751 GDSC1 3.7206 8.0327 0.5587 9.7228
SKG-IIIa GDSC1 3.8953 8.106 0.6405 8.7018
JEG-3 GDSC1 4.1356 10.1423 -0.1723 13.4013
SW756 GDSC1 4.7282 6.1712 1.8921 0.2187
HeLa GDSC1; CTRP2 7.7475 8.8758 5.6792 0.122
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug

References

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2 Combination of the PI3K inhibitor ZSTK474 with a PSMA-targeted immunotoxin accelerates apoptosis and regression of prostate cancer. Neoplasia. 2013 Oct;15(10):1172-83.
3 Synthesis and biological evaluation of novel analogues of the pan class I phosphatidylinositol 3-kinase (PI3K) inhibitor 2-(difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1H-benzimidazole (ZSTK474). J Med Chem. 2011 Oct 27;54(20):7105-26. doi: 10.1021/jm200688y. Epub 2011 Sep 27.
4 The dual pathway inhibitor rigosertib is effective in direct patient tumor xenografts of head and neck squamous cell carcinomas. Mol Cancer Ther. 2013 Oct;12(10):1994-2005. doi: 10.1158/1535-7163.MCT-13-0206. Epub 2013 Jul 19.