Details of the Drug

General Information of Drug (ID: DMVJW0S)

Drug Name
AT-406
Synonyms
1071992-99-8; SM 406; (5S,8S,10aR)-N-benzhydryl-5-((S)-2-(methylamino)propanamido)-3-(3-methylbutanoyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazocine-8-carboxamide; CHEMBL2158051; QCR-136; UNII-N65WC8PXDD; N65WC8PXDD; AT406 (SM-406, ARRY-334543); J-501625; (5S,8S,10aR)-N-(Diphenylmethyl)-5-[(N-methyl-L-alanyl)amino]-3-(3-methylbutanoyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazocine-8-carboxamide; AT-406/Debio-1143
Indication
Disease Entry ICD 11 Status REF
Squamous head and neck cell carcinom 2D60.0 Phase 3 [1]
Solid tumour/cancer 2A00-2F9Z Phase 2 [2]
Lymphoma 2A80-2A86 Phase 1/2 [3]
Acute myeloid leukaemia 2A60 Phase 1 [4]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 1 Molecular Weight (mw) 561.7
Logarithm of the Partition Coefficient (xlogp) 3.1
Rotatable Bond Count (rotbonds) 9
Hydrogen Bond Donor Count (hbonddonor) 3
Hydrogen Bond Acceptor Count (hbondacc) 5
Chemical Identifiers
Formula
C32H43N5O4
IUPAC Name
(5S,8S,10aR)-N-benzhydryl-5-[[(2S)-2-(methylamino)propanoyl]amino]-3-(3-methylbutanoyl)-6-oxo-1,2,4,5,8,9,10,10a-octahydropyrrolo[1,2-a][1,5]diazocine-8-carboxamide
Canonical SMILES
C[C@@H](C(=O)N[C@H]1CN(CC[C@H]2CC[C@H](N2C1=O)C(=O)NC(C3=CC=CC=C3)C4=CC=CC=C4)C(=O)CC(C)C)NC
InChI
InChI=1S/C32H43N5O4/c1-21(2)19-28(38)36-18-17-25-15-16-27(37(25)32(41)26(20-36)34-30(39)22(3)33-4)31(40)35-29(23-11-7-5-8-12-23)24-13-9-6-10-14-24/h5-14,21-22,25-27,29,33H,15-20H2,1-4H3,(H,34,39)(H,35,40)/t22-,25+,26-,27-/m0/s1
InChIKey
LSXUTRRVVSPWDZ-MKKUMYSQSA-N
Cross-matching ID
PubChem CID
25022340
CAS Number
1071992-99-8
UNII
N65WC8PXDD
DrugBank ID
DB16305
TTD ID
D03MXK
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Cellular inhibitor of apoptosis 1 (BIRC2) TTQ5LRD BIRC2_HUMAN Inhibitor [5]
Cellular inhibitor of apoptosis 2 (BIRC3) TTIRY6K BIRC3_HUMAN Inhibitor [5]
Inhibitor of apoptosis protein (hIAP) TTS74QB XIAP_HUMAN ; BIRC2_HUMAN ; BIRC3_HUMAN ; BIRC1_HUMAN ; BIRC7_HUMAN ; BIRC5_HUMAN Modulator [4]
X-linked inhibitor of apoptosis protein (XIAP) TTR7B60 XIAP_HUMAN Inhibitor [5]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 87 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JK1 CTRP2 6.3283 9.3281 4.6327 7.3697
JM1 CTRP2 6.9333 8.8741 5.2839 1.8334
MOLM-16 CTRP2 -1.2673 24.945 -10.0247 53.7134
M-07e CTRP2 0.262 2.183 0.2597 38.5305
NB4 CTRP2 2.0806 6.1816 1.6803 27.7787
SK-MM-2 CTRP2 3.4752 16.7905 -1.5957 32.5675
SR CTRP2 4.4117 6.5461 4.1042 11.9824
PL21 CTRP2 5.5455 11.9071 2.6876 14.9753
MOTN-1 CTRP2 5.5568 9.5226 3.884 10.0642
Karpas-299 CTRP2 5.6959 8.3083 4.6103 6.736
MM1.S CTRP2 5.8796 7.4448 5.2025 3.8705
RCH-ACV CTRP2 5.9875 14.3 1.8691 22.2273
HEL 92.1.7 CTRP2 6.0884 10.3219 3.217 6.2997
MOLP-2 CTRP2 6.1079 8.4032 4.9175 4.6155
L-428 CTRP2 6.1787 9.5746 4.39 6.6985
SEM CTRP2 6.1853 11.2404 3.5629 10.1407
DB CTRP2 6.2697 8.4006 5.0484 3.7715
ST486 CTRP2 6.2924 8.3761 5.0782 3.607
KMS-34 CTRP2 6.3624 7.7886 5.421 2.0667
Ri-1 CTRP2 6.3681 9.5033 4.5767 7.5919
MOLT-16 CTRP2 6.4207 10.2509 4.2459 9.3344
SU-DHL-6 CTRP2 6.5227 10.5419 4.1807 9.4545
Kasumi-1 CTRP2 6.6313 21.9161 -1.4078 25.5307
RPMI-8226 CTRP2 6.6617 9.4618 4.8189 4.075
AML-193 CTRP2 6.6718 9.1553 4.9758 3.4158
L-540 CTRP2 6.6852 11.6086 3.7766 11.2922
MHH-CALL-4 CTRP2 6.7334 8.9882 5.0995 3.8474
SUP-T11 CTRP2 6.7625 9.3173 4.9609 3.3409
SKM-1 CTRP2 6.7706 10.4748 4.4014 5.6234
MOLM-6 CTRP2 6.792 10.6789 4.3168 8.0772
OCI-AML-2 CTRP2 6.8184 9.6143 4.8561 3.6842
HL-60 CTRP2 6.8731 9.3381 5.0265 2.9187
KMS-11 CTRP2 6.8927 10.1898 4.6291 4.4973
ME1 CTRP2 6.9271 10.13 4.6822 4.2297
HuT 78 CTRP2 6.9523 10.3727 4.5823 4.5987
SU-DHL-4 CTRP2 6.9769 9.0207 5.243 2.6405
Mono-Mac-1 CTRP2 6.9783 9.3339 5.0976 2.4968
SUP-B15 CTRP2 7.0669 10.9251 4.3948 5.1902
OCI-AML-3 CTRP2 7.1065 8.9632 5.3463 1.4096
RPMI-6666 CTRP2 7.1188 11.6296 4.0887 6.359
NOMO-1 CTRP2 7.136 14.0802 2.896 11.1422
JJN-3 CTRP2 7.1561 9.9041 4.9437 2.8695
KMS-12-BM CTRP2 7.1664 8.9573 5.3825 1.2225
MC116 CTRP2 7.1892 8.2411 5.6911 0.3808
Ci-1 CTRP2 7.204 15.4597 2.2648 13.4487
Karpas-620 CTRP2 7.2109 8.54 5.5826 0.5471
Mino CTRP2 7.2327 8.5697 5.5809 0.5378
U-937 CTRP2 7.257 11.4357 4.2802 5.3736
RL CTRP2 7.3071 10.3436 4.8339 3.1047
Daudi CTRP2 7.3208 13.7379 3.2026 9.6223
TALL-1 [Human adult T-ALL] CTRP2 7.3329 11.0728 4.506 4.3607
RS4;11 CTRP2 7.3534 9.9238 5.0566 2.2026
Raji CTRP2 7.3551 11.288 4.4181 4.6803
KYO-1 CTRP2 7.3612 9.1387 5.4079 0.9663
Kasumi-2 CTRP2 7.377 12.9847 3.6124 7.8915
Mono-Mac-6 CTRP2 7.3968 14.2161 3.0236 13.5406
SU-DHL-10 CTRP2 7.4222 9.3855 5.3343 1.5733
JeKo-1 CTRP2 7.4434 10.4146 4.8859 2.7394
OCI-AML-5 CTRP2 7.4776 11.1869 4.547 4.0051
HPB-ALL CTRP2 7.4894 10.7101 4.7776 3.0965
SUP-T1 CTRP2 7.5191 15.413 2.5251 11.9367
Granta-519 CTRP2 7.5374 16.1694 2.1659 13.2488
REC-1 CTRP2 7.5534 11.8901 4.2633 5.0229
F-36P CTRP2 7.5695 11.1402 4.6277 3.5742
AMO1 CTRP2 7.6843 8.8113 5.6785 0.1866
SU-DHL-8 CTRP2 7.7395 9.2085 5.555 0.4629
MHH-CALL-3 CTRP2 7.7423 14.7102 3.0321 9.6281
OCI-M1 CTRP2 7.7835 13.5327 3.6318 7.2063
NU-DUL-1 CTRP2 7.8657 9.1938 5.6107 0.2634
SET-2 CTRP2 7.8769 12.2703 4.294 4.4785
GDM-1 CTRP2 7.8782 13.0338 3.9345 5.879
HD-MY-Z CTRP2 7.9261 12.9996 3.9822 5.6276
MOLP-8 CTRP2 8.0359 9.4428 5.5864 0.1861
NU-DHL-1 CTRP2 8.0425 9.8569 5.4361 0.4688
P3HR-1 CTRP2 8.0434 9.6243 5.5237 0.3939
Hs 611.T CTRP2 8.1539 10.1168 5.384 0.5363
U266B1 CTRP2 8.2158 10.1356 5.4031 0.4659
KO52 CTRP2 8.4419 14.0713 3.8097 5.6295
BV-173 CTRP2 8.5535 10.1602 5.5258 0.1551
OCI-Ly3 CTRP2 8.8297 25.0286 -1.2382 21.4288
SUP-HD1 CTRP2 8.9547 20.8484 0.9053 15.2972
EJM CTRP2 9.1152 31.0892 -4.02 26.6179
THP-1 CTRP2 9.1496 20.054 1.4283 13.3178
OCI-Ly19 CTRP2 9.4866 24.8272 -0.6557 18.9768
OCI-Ly10 CTRP2 9.826 26.1074 -1.0368 19.4497
KMS-18 CTRP2 11.167 23.0097 1.356 10.8893
KMS-20 CTRP2 11.7939 44.3297 -8.5435 29.3689
⏷ Show the Full List of 87 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 18 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE8 CTRP2 8.4893 9.9809 5.5647 0.1217
TE15 CTRP2 8.8458 20.0149 1.2338 14.4083
OE21 CTRP2 6.178 10.9883 3.6829 9.6571
EC-GI-10 CTRP2 7.0265 10.63 4.5095 4.7838
TE-4 CTRP2 7.1652 11.7851 4.046 6.4612
OE19 CTRP2 7.3189 9.1979 5.3604 1.1575
TE-14 CTRP2 7.6182 13.5064 3.5297 7.8551
KYSE-450 CTRP2 7.7104 8.9673 5.6325 0.2017
KYSE-150 CTRP2 8.0049 9.4218 5.5821 0.2008
KYSE-410 CTRP2 8.0379 10.3524 5.2377 0.985
KYSE-520 CTRP2 8.0975 13.8495 3.6917 6.532
OE33 CTRP2 8.1454 22.6852 -0.5965 20.9105
KYSE-30 CTRP2 8.1534 9.425 5.6358 0.0995
TE-1 CTRP2 8.3975 10.1958 5.4543 0.2992
TE-6 CTRP2 8.4267 10.1115 5.4959 0.2236
KYSE-70 CTRP2 8.4858 10.0601 5.536 0.1556
KYSE-510 CTRP2 8.5163 9.7834 5.6407 0.0525
TE-5 CTRP2 8.9571 16.639 2.9335 8.2692
⏷ Show the Full List of 18 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 27 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
N2a-PK1 CTRP2 8.1885 10.0257 5.4333 0.413
Capan-1 CTRP2 5.7617 11.9929 2.8313 13.9567
TCC-Pan2 CTRP2 6.8453 10.1448 4.6173 4.6177
SU.86.86 CTRP2 7.3 8.6877 5.5648 0.5402
Panc 02.03 CTRP2 7.4234 9.4926 5.2886 1.305
Panc 03.27 CTRP2 7.4578 14.9157 2.7245 11.2741
HPAC CTRP2 7.4606 11.7751 4.2561 5.1799
Panc 05.04 CTRP2 7.5886 9.2576 5.4697 0.6228
Panc 08.13 CTRP2 7.5943 14.0966 3.2255 9.0984
L3.3 CTRP2 7.7153 10.5717 4.9749 2.1146
PaTu 8988t CTRP2 7.8287 8.9463 5.6842 0.1
Panc 10.05 CTRP2 7.8592 11.0467 4.8448 2.4326
AsPC-1 CTRP2 7.9547 10.6526 5.0701 1.5663
YAPC CTRP2 7.9684 9.1218 5.6739 0.0884
PaTu 8902 CTRP2 7.9989 9.19 5.6613 0.0968
PK-59 CTRP2 8.0682 11.1833 4.9011 2.031
Hs 766T CTRP2 8.0727 9.8641 5.4461 0.4336
KP-2 CTRP2 8.2232 9.453 5.6508 0.0753
PSN1 CTRP2 8.3344 11.8266 4.7649 2.2497
Panc 04.03 CTRP2 8.3392 10.5334 5.3033 0.6369
HuP-T3 CTRP2 8.3499 18.2885 1.7212 13.5277
SW1990 CTRP2 8.3957 10.4041 5.3766 0.448
Capan-2 CTRP2 8.4796 10.8802 5.2298 0.7442
HuP-T4 CTRP2 8.5072 19.0462 1.4642 14.1616
PK-45H CTRP2 8.6432 15.0637 3.4729 6.6547
SNU-410 CTRP2 8.6956 11.2829 5.1678 0.785
PaTu 8988s CTRP2 10.1717 21.0966 1.6174 11.2888
⏷ Show the Full List of 27 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CHP-126 CTRP2 6.5631 10.1688 4.3969 8.1474
CHP-212 CTRP2 6.8065 9.6831 4.8144 3.8715
Kelly CTRP2 7.4103 8.9442 5.5128 0.6149
NB1 CTRP2 7.7158 10.5397 4.9894 2.0627
KP-N-SI9s CTRP2 7.751 10.7324 4.9235 2.2619
KP-N-YN CTRP2 8.6974 10.3316 5.5184 0.138
SK-N-SH CTRP2 8.7189 10.4732 5.4771 0.1835
SK-N-BE(2) CTRP2 8.7329 10.5821 5.444 0.2252
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-869 CTRP2 8.0565 14.4966 3.3548 7.9023
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CAL-78 CTRP2 6.6275 9.847 4.6044 5.016
Hs 822.T CTRP2 6.9759 8.6256 5.4226 1.2705
A-673 CTRP2 7.0429 10.9884 4.347 5.421
TC71 CTRP2 7.128 8.7765 5.4407 1.0586
MG-63 CTRP2 7.9446 10.1234 5.2866 0.907
Hs 888.T CTRP2 7.9972 10.6185 5.1067 1.4133
SaOS-2 CTRP2 8.1246 11.331 4.8672 2.0944
HOS CTRP2 8.2294 9.8487 5.5148 0.2469
SJSA-1 CTRP2 8.366 10.3912 5.3691 0.4758
G-292 clone A141B1 CTRP2 8.4902 14.0228 3.8625 5.3696
SK-ES-1 CTRP2 8.7253 10.247 5.5571 0.0952
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 55 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Hs 578T CTRP2 0.6657 17.8473 -4.7753 43.7107
EFM-192A CTRP2 2.4131 11.9026 -0.2734 32.5172
MDA-MB-231 CTRP2 2.4705 8.8998 1.1142 28.4591
BT-549 CTRP2 3.1251 16.4147 -1.7373 33.6979
BT-474 CTRP2 3.7722 8.9424 2.44 20.1253
MDA-MB-157 CTRP2 4.1828 9.3144 2.6822 18.1345
Hs 578Bst CTRP2 6.861 9.2836 5.0444 2.8638
HCC1143 CTRP2 7.0157 11.7617 3.9493 7.0911
ZR-75-1 CTRP2 7.0417 8.774 5.3938 1.3059
MDA-MB-415 CTRP2 7.0481 11.6726 4.0167 6.7634
HCC1419 CTRP2 7.435 11.5507 4.3462 4.8562
HCC1428 CTRP2 7.577 11.137 4.6338 3.5412
ZR-75-30 CTRP2 7.6145 10.9477 4.7448 3.0721
HCC38 CTRP2 7.6608 11.3145 4.6037 3.554
SK-BR-3 CTRP2 7.6832 10.0696 5.1776 1.4458
MDA-MB-453 CTRP2 7.7173 10.78 4.8827 2.4445
HCC202 CTRP2 7.7927 15.8192 2.5264 11.4889
T-47D CTRP2 8.0528 12.5943 4.2535 4.416
MDA-MB-361 CTRP2 8.1494 9.6942 5.5397 0.229
CAL-85-1 CTRP2 8.1868 19.9401 0.7912 16.8601
AU565 CTRP2 8.3983 10.3055 5.4144 0.3719
CAL-51 CTRP2 9.5828 16.8726 3.2179 8.5402
BT 139 CTRP2 6.3926 13.2919 2.7066 13.2157
BT 428 CTRP2 6.5189 8.4224 5.2239 2.6335
BT 482 CTRP2 6.7135 8.9223 5.1177 2.7775
BT 159 CTRP2 6.735 11.357 3.9394 7.5934
BT 286 CTRP2 6.8773 8.4482 5.4452 1.293
BT 145 CTRP2 7.2486 12.1164 3.944 6.748
BT 131 CTRP2 7.2488 8.5377 5.6013 0.4719
BT 271 CTRP2 7.3562 8.966 5.4778 0.7533
BT 416 CTRP2 7.373 8.8961 5.5147 0.6338
BT 328 CTRP2 7.4408 9.2232 5.4126 0.8891
BT 216 CTRP2 7.505 10.3991 4.9303 2.5019
BT 422 CTRP2 7.5432 8.7445 5.6481 0.2275
BT 232 CTRP2 7.5494 8.8842 5.5983 0.3264
BT147 CTRP2 7.5688 9.2574 5.4606 0.66
BT 444 CTRP2 7.6126 8.7587 5.6701 0.1678
BT 224 CTRP2 7.6233 10.3534 5.02 2.0476
BT 228 CTRP2 7.6778 8.9692 5.619 0.2359
BT 245 CTRP2 7.7234 9.4335 5.4611 0.5675
BT 320 CTRP2 7.7349 8.7411 5.7213 0.0752
BT164 CTRP2 7.7443 9.3316 5.5101 0.4371
BT 330 CTRP2 7.7601 9.14 5.589 0.2639
BT 504 CTRP2 7.8018 8.9477 5.674 0.1175
BT 340 CTRP2 7.8106 8.8839 5.6993 0.0864
BT 333 CTRP2 7.824 9.1669 5.6044 0.2156
BT 112 CTRP2 7.9511 9.1985 5.6411 0.1293
BT 440 CTRP2 7.96 9.0796 5.6853 0.0782
BT 231 CTRP2 8.0182 13.3046 3.898 5.834
BT 179 CTRP2 8.0443 9.4273 5.5951 0.1713
BT 359 CTRP2 8.1322 9.4419 5.6223 0.1179
BT 239 CTRP2 8.1683 9.6194 5.5735 0.173
BT 172 CTRP2 8.2942 9.6016 5.6252 0.0894
BT 248 CTRP2 8.312 9.6778 5.6055 0.1065
BT 187 CTRP2 9.8285 19.8933 1.9627 10.58
⏷ Show the Full List of 55 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
8-MG-BA CTRP2 3.6281 8.3437 2.555 20.074
SW1783 CTRP2 6.2072 15.3845 1.5093 18.0243
KNS-60 CTRP2 6.2801 12.6088 2.9564 12.4359
YH-13 CTRP2 6.6268 12.5323 3.2721 10.5221
GaMG CTRP2 6.7989 8.35 5.4432 1.3886
KALS-1 CTRP2 7.0684 10.3953 4.6519 4.1469
GMS-10 CTRP2 7.2326 13.6435 3.1839 9.8405
CCF-STTG1 CTRP2 7.6245 9.0314 5.574 0.3471
KNS-81 CTRP2 7.6285 8.5803 5.7386 0.0735
SW1088 CTRP2 7.64 9.6327 5.3409 0.9598
YKG-1 CTRP2 7.6483 9.3169 5.4734 0.5778
DK-MG CTRP2 7.6979 11.0744 4.7373 3.0034
SF539 CTRP2 7.7493 10.5247 5.0149 1.9402
SF268 CTRP2 8.0122 10.4679 5.1775 1.1812
KNS-42 CTRP2 8.0366 14.328 3.4222 7.6678
KG-1-C CTRP2 8.0934 9.3328 5.646 0.0981
U-251MG CTRP2 8.1382 9.6293 5.5587 0.2021
Becker CTRP2 8.1412 9.6129 5.5656 0.1908
TM-31 CTRP2 8.2944 13.3334 4.0607 4.8564
42-MG-BA CTRP2 8.2948 9.8005 5.5567 0.168
U-118MG CTRP2 8.3425 9.6757 5.617 0.0906
Hs 683 CTRP2 8.3543 17.1919 2.2587 11.6103
SNB-75 CTRP2 8.3887 10.6061 5.2966 0.6285
DBTRG-05MG CTRP2 8.6648 10.3397 5.5039 0.1607
M059K CTRP2 9.6392 17.1973 3.1029 6.8035
GOS-3 CTRP2 12.3774 23.065 2.0526 7.3962
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ESS-1 CTRP2 1.3969 2.3741 1.3969 30.9622
HEC-50B CTRP2 6.9687 9.9411 4.8021 5.0208
EFE-184 CTRP2 7.0145 9.5809 5.0045 2.8149
JHUEM-3 CTRP2 7.0937 13.3996 3.2005 10.0045
EN CTRP2 7.338 12.974 3.5896 8.0441
JHUEM-7 CTRP2 7.4228 9.264 5.3864 0.9852
MFE-319 CTRP2 7.9582 9.3819 5.5786 0.2194
HEC-151 CTRP2 8.0976 9.5699 5.5645 0.2037
MFE-296 CTRP2 8.2291 10.0091 5.456 0.3522
HEC-1-A CTRP2 8.6201 10.1868 5.5406 0.1266
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 12 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TUHR10TKB CTRP2 1.3666 5.0693 1.1687 43.0579
TUHR14TKB CTRP2 7.2539 9.3416 5.2613 1.5628
KMRC-3 CTRP2 7.3433 16.2398 1.9846 14.2402
KMRC-1 CTRP2 7.7133 14.4054 3.1599 9.1729
VMRC-RCW CTRP2 7.8973 14.2733 3.353 8.1394
RCC10RGB CTRP2 8.1893 9.8455 5.5004 0.2836
Caki-2 CTRP2 8.3303 15.4539 3.0814 8.5683
VMRC-RCZ CTRP2 8.3422 10.2066 5.4284 0.3648
UO-31 CTRP2 8.4504 10.1989 5.4737 0.2518
CAL-54 CTRP2 8.55 10.6512 5.3474 0.4477
KMRC-2 CTRP2 9.0769 14.7685 3.8754 4.6458
Caki-1 CTRP2 10.555 18.6096 3.0036 6.1411
⏷ Show the Full List of 12 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LS123 CTRP2 4.6921 9.7125 2.9897 15.6743
NCI-H747 CTRP2 4.8208 11.6779 2.1526 18.6349
SNU-1033 CTRP2 5.4484 9.2366 3.928 10.1148
LoVo CTRP2 6.5549 12.0804 3.4406 9.9632
SW1116 CTRP2 6.5759 18.914 0.047 21.9234
C2BBe1 CTRP2 6.579 8.9679 5.0007 3.4568
CCK-81 CTRP2 6.6612 10.0556 4.5268 5.2826
GP2d CTRP2 6.8808 24.5938 -2.5428 27.4732
SW948 CTRP2 6.9308 9.0298 5.2099 2.1203
LS1034 CTRP2 7.4041 9.3401 5.3442 1.1368
NCI-H508 CTRP2 7.4144 9.1383 5.435 0.8404
RCM-1 [Human ESC] CTRP2 7.4634 9.4674 5.3208 1.1632
SW1417 CTRP2 7.5258 9.596 5.2983 1.1839
COLO 678 CTRP2 7.5357 12.7118 3.8568 6.67
HCC-56 CTRP2 7.5599 8.7425 5.6554 0.2085
RKO CTRP2 7.7096 9.7381 5.3314 0.9376
HCT 8 CTRP2 7.8729 8.7896 5.7526 0.0345
T84 CTRP2 7.8939 10.0607 5.288 0.937
SNU-C4 CTRP2 7.9739 9.0923 5.6859 0.0757
HT-55 CTRP2 7.9784 9.5724 5.5167 0.3249
SNU-407 CTRP2 8.0761 15.7115 2.7815 10.084
COLO201 CTRP2 8.4885 14.1669 3.7944 5.6297
SNU-503 CTRP2 8.5271 15.8313 3.0334 8.4757
KM12 CTRP2 8.7596 10.2662 5.5626 0.0862
SW620 CTRP2 8.8391 10.2245 5.6036 0.0496
NCI-H716 CTRP2 8.9523 16.5859 2.9554 8.1944
MDST8 CTRP2 9.0091 14.7999 3.8211 4.9178
COLO 320 CTRP2 9.0097 11.3335 5.2798 0.4144
CL-11 CTRP2 9.0768 11.1553 5.3697 0.2504
SNU-C5 CTRP2 9.1124 21.3305 0.7828 15.443
SNU-61 CTRP2 9.2858 29.1396 -2.9256 24.3926
SNU-C1 CTRP2 9.6649 20.202 1.708 11.6595
⏷ Show the Full List of 32 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-398 CTRP2 6.8476 15.9436 1.7472 15.9724
HuH-6 CTRP2 6.9364 9.1596 5.1526 2.3359
SNU-387 CTRP2 7.346 9.5806 5.207 1.6626
SNU-761 CTRP2 7.3677 8.9085 5.5071 0.659
JHH-1 CTRP2 7.3704 8.5707 5.6421 0.3079
Hep-G2 CTRP2 7.4232 9.3872 5.334 1.1539
HLF CTRP2 7.5668 9.3031 5.4411 0.7158
PLC/PRF/5 CTRP2 7.8218 14.4697 3.2054 8.83
HuH-1 CTRP2 8.0421 9.5917 5.5351 0.2687
SNU-423 CTRP2 8.2421 16.5503 2.4912 10.9247
JHH-2 CTRP2 8.2851 9.7807 5.5601 0.1655
SNU-886 CTRP2 8.3886 9.8886 5.5603 0.1444
SNU-449 CTRP2 8.6339 11.5309 5.0411 1.1531
JHH-6 CTRP2 9.5908 19.4013 2.0399 10.6292
SNU-475 CTRP2 9.616 17.9143 2.7563 8.0739
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 81 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
EPLC-272H CTRP2 3.3216 13.3614 -0.0732 29.501
Sq-1 CTRP2 4.9222 8.9179 3.5912 12.6977
NCI-H522 CTRP2 4.984 12.1199 2.0832 18.5238
SK-LU-1 CTRP2 5.4304 12.0259 2.5278 15.8464
NCI-H2228 CTRP2 5.5334 17.2469 0.0118 24.0947
NCI-H1666 CTRP2 5.7855 10.4307 3.6319 10.6384
NCI-H1092 CTRP2 6.0094 12.717 2.6789 14.064
NCI-H1435 CTRP2 6.0236 7.7793 3.4989 0.52
SW1271 CTRP2 6.0773 10.0541 4.0669 8.2459
NCI-H446 CTRP2 6.257 8.6358 4.9213 4.3259
HCC4006 CTRP2 6.6331 9.0969 4.9766 3.4715
NCI-H1184 CTRP2 6.6441 10.5942 4.2479 6.4682
NCI-H1755 CTRP2 6.9593 15.6371 1.9876 14.9037
NCI-H2087 CTRP2 7.0734 9.3454 5.1523 2.167
HCC2935 CTRP2 7.1256 12.0106 3.9073 7.0882
LK2 CTRP2 7.2009 8.0158 5.7792 0.1069
NCI-H2126 CTRP2 7.229 8.5665 5.5805 0.5415
NCI-H2110 CTRP2 7.2326 15.6759 2.1795 13.7165
NCI-H1915 CTRP2 7.2723 13.8941 3.09 10.1486
NCI-H2172 CTRP2 7.3101 9.9143 5.0349 2.3329
DMS 273 CTRP2 7.333 11.0824 4.5014 4.3786
DMS 53 CTRP2 7.3387 9.6966 5.1509 1.8722
EKVX CTRP2 7.3579 12.2484 3.9572 6.5296
LUDLU-1 CTRP2 7.4085 13.6717 3.2992 9.097
LOU-NH91 CTRP2 7.4116 15.9885 2.1607 17.4491
NCI-H2196 CTRP2 7.4253 15.3216 2.5003 12.1857
COR-L95 CTRP2 7.4327 14.9166 2.7054 11.3888
HCC1438 CTRP2 7.4401 9.7766 5.1731 1.6885
EBC-1 CTRP2 7.5142 11.977 4.1956 5.3462
LXF 289 CTRP2 7.553 12.2839 4.0747 5.7737
IA-LM CTRP2 7.5857 9.2197 5.4836 0.5873
Calu-6 CTRP2 7.5901 11.8666 4.2987 4.833
NCI-H2286 CTRP2 7.703 10.5173 4.9922 2.0658
NCI-H2122 CTRP2 7.7289 9.349 5.4967 0.4763
HOP-92 CTRP2 7.7379 10.1055 5.1911 1.3547
NCI-H810 CTRP2 7.7475 14.8377 2.9736 9.8474
DMS 454 CTRP2 7.7515 12.3935 4.1549 5.1833
COLO 668 CTRP2 7.7552 14.7463 3.0237 9.6407
ChaGo-K-1 CTRP2 7.7756 10.3829 5.0914 1.6525
NCI-H2023 CTRP2 7.8078 9.7714 5.3649 0.7748
PC-14 CTRP2 7.8587 9.5492 5.4755 0.4634
NCI-H2029 CTRP2 7.8634 17.2231 1.8891 13.7128
NCI-H1623 CTRP2 7.8655 18.0789 1.4692 15.1717
NCI-H1793 CTRP2 7.896 13.7671 3.5959 7.1867
NCI-H460 CTRP2 7.9118 10.1811 5.2471 1.0448
VMRC-LCD CTRP2 7.9161 9.4252 5.5462 0.2905
NCI-H226 CTRP2 7.9247 9.3278 5.5852 0.2182
NCI-H520 CTRP2 7.9266 14.9141 3.0634 9.2258
SK-MES-1 CTRP2 7.9452 15.1994 2.938 9.6824
NCI-H2170 CTRP2 8.0235 11.2401 4.8516 2.2441
HOP-62 CTRP2 8.0393 9.7237 5.4851 0.3651
NCI-H1694 CTRP2 8.0569 9.8888 5.43 0.476
NCI-H661 CTRP2 8.081 10.1976 5.3202 0.9972
NCI-H1944 CTRP2 8.1139 13.8584 3.6983 6.484
KNS-62 CTRP2 8.1691 9.7014 5.5446 0.2157
DMS 114 CTRP2 8.211 9.8203 5.518 0.247
NCI-H1563 CTRP2 8.2803 10.0473 5.4624 0.3224
HCC1195 CTRP2 8.3108 13.3684 4.0547 4.8594
NCI-H1650 CTRP2 8.3578 13.1463 4.1861 4.3082
NCI-H1395 CTRP2 8.3742 10.6985 5.2543 0.7389
NCI-H1651 CTRP2 8.3848 10.1532 5.4649 0.285
NCI-H1792 CTRP2 8.3879 10.7516 5.2395 0.7688
COR-L105 CTRP2 8.4301 12.2306 4.6404 2.587
NCI-H1869 CTRP2 8.4555 10.9028 5.2102 0.8062
SW1573 CTRP2 8.5382 10.9126 5.2429 0.9309
DV-90 CTRP2 8.6138 32.1327 -4.9252 28.767
Calu-1 CTRP2 8.6197 9.8899 5.6403 0.0445
NCI-H1355 CTRP2 8.7566 10.7437 5.3953 0.293
LC-1/sq-SF CTRP2 8.7593 14.9384 3.6049 6.0114
NCI-H1339 CTRP2 9.099 16.8462 2.9276 8.1056
NCI-H1373 CTRP2 9.1234 16.0773 3.3028 6.6909
NCI-H322 CTRP2 9.1942 15.384 3.6652 5.2787
NCI-H889 CTRP2 9.2978 22.216 0.4834 19.7347
NCI-H647 CTRP2 9.3741 20.2064 1.5095 12.7263
T3M-10 CTRP2 9.3946 19.1953 2.0078 11.0056
NCI-H2342 CTRP2 9.5023 18.3611 2.4743 9.2236
NCI-H1105 CTRP2 9.607 37.567 -6.8553 30.012
RERF-LC-Ad2 CTRP2 10.6591 18.9607 2.906 6.3642
A-549 CTRP2 11.8062 20.6527 2.7991 5.5958
NCI-H441 CTRP2 12.6062 24.477 1.5519 8.6977
Hs 888.Lu CTRP2 7.0803 10.3306 4.6911 3.9723
⏷ Show the Full List of 81 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 28 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
2004 CTRP2 7.0247 9.136 5.2191 1.9708
SK-OV-3 CTRP2 1.3034 5.8152 0.9312 32.7892
OVCAR-4 CTRP2 4.7833 8.7697 3.5275 13.2886
Caov-3 CTRP2 4.8545 11.1166 2.4593 17.3868
COV434 CTRP2 5.062 11.4123 2.5034 16.746
COV644 CTRP2 5.9873 19.9963 -0.9792 25.7462
OVK18 CTRP2 7.2989 9.1652 5.3638 1.1637
TOV-21G CTRP2 7.3071 11.3831 4.34 5.0607
OAW42 CTRP2 7.3142 8.483 5.6518 0.3116
TYK-nu CTRP2 7.4205 9.9123 5.1012 1.9658
HEY A8 CTRP2 7.4476 8.9229 5.5387 0.5217
OV7 CTRP2 7.4554 19.8484 0.2802 19.6484
OC 314 CTRP2 7.4796 9.3268 5.3887 0.9336
OVCAR-8 CTRP2 7.4971 10.0494 5.0838 1.9486
JHOM-1 CTRP2 7.6754 13.4388 3.6024 7.4802
EFO-21 CTRP2 7.7176 12.0095 4.3144 4.6029
OV56 CTRP2 7.8039 9.0284 5.6464 0.1547
MCAS CTRP2 7.8362 9.8156 5.3604 0.7697
FU-OV-1 CTRP2 7.897 9.5235 5.5016 0.5291
OAW28 CTRP2 7.9196 13.3566 3.8082 6.3188
TOV-112D CTRP2 7.9808 13.575 3.7449 6.4832
A2780 CTRP2 8.2836 16.9041 2.3486 11.3886
IGROV-1 CTRP2 8.3481 9.973 5.5155 0.214
RMG-I CTRP2 8.5746 10.4468 5.4322 0.2842
COV362 CTRP2 8.5976 17.2947 2.3787 10.8116
EFO-27 CTRP2 8.6041 12.9681 4.4113 3.2189
OVCAR-5 CTRP2 8.6327 10.3407 5.4918 0.1822
SNU-840 CTRP2 8.7889 10.3804 5.5342 0.1079
⏷ Show the Full List of 28 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 18 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Yamato-SS CTRP2 7.0523 10.8113 4.4397 5.0292
KYM-1 CTRP2 -2.0347 -1.2489 -2.0347 53.8238
GCT CTRP2 -0.4375 2.8926 -0.4791 43.2865
A-204 CTRP2 5.7357 10.8365 3.3865 11.755
Tm87-16 CTRP2 6.006 8.1092 4.9798 4.5495
Rh18 CTRP2 6.5445 9.3847 4.7705 4.4632
MES-SA CTRP2 7.0951 10.0033 4.8572 3.2892
BT-12 CTRP2 7.1663 7.9498 5.7897 0.1
BT-16 CTRP2 7.202 13.7695 3.099 10.2288
TE 441.T CTRP2 7.7109 12.0768 4.2783 4.7529
TTC-709 CTRP2 7.7185 9.1835 5.5557 0.3467
RKN CTRP2 7.7309 11.1135 4.7393 2.9582
SW982 CTRP2 7.7737 9.1805 5.5795 0.2772
SK-LMS-1 CTRP2 8.5176 10.1762 5.507 0.1864
HT-1080 CTRP2 8.9275 17.318 2.5915 9.5677
G-401 CTRP2 8.9936 11.279 5.2934 0.3952
G-402 CTRP2 10.0576 18.74 2.6477 7.9244
RD CTRP2 12.6495 29.5269 -0.7542 15.0798
⏷ Show the Full List of 18 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Thigh Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
H-STS CTRP2 7.1965 8.1484 5.7292 0.1953
P-STS CTRP2 7.405 12.9119 3.6679 7.6247
SYO-1 CTRP2 7.8345 9.1781 5.6044 0.2124
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Clivus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U-CH1 CTRP2 7.4296 14.1065 3.1014 9.8482
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H2452 CTRP2 7.1942 9.3609 5.2181 1.782
MPP 89 CTRP2 7.1997 10.8809 4.508 4.5383
JL-1 CTRP2 7.7768 10.7215 4.9431 2.1658
IST-Mes1 CTRP2 8.18 9.8634 5.4901 0.305
NCI-H2052 CTRP2 9.8674 17.8351 2.9484 7.0887
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
VCaP CTRP2 6.0189 9.512 4.2893 7.4256
NCI-H660 CTRP2 6.0547 10.6877 3.7313 9.6917
PaCa-3 CTRP2 7.9197 13.6131 3.6858 6.7995
LNCaP clone FGC CTRP2 8.4049 10.4899 5.348 0.5047
DU145 CTRP2 8.6375 11.3552 5.1133 0.9551
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 CTRP2 8.4038 11.7567 4.8322 1.9633
Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-375 CTRP2 2.0083 7.7774 1.0692 30.0299
Hs 852.T CTRP2 3.0755 10.4575 1.0516 26.9086
Hs 944.T CTRP2 4.3982 12.3477 1.4341 28.7144
A101D CTRP2 4.6859 8.3098 3.6469 13.0451
Hs 940.T CTRP2 5.3837 14.1241 1.4416 19.9521
LOX-IMVI CTRP2 6.2962 12.5289 3.0096 12.1919
Malme-3M CTRP2 6.619 23.2893 -2.104 27.0607
Hs 688(A).T CTRP2 6.8962 10.3201 4.5682 4.741
SK-MEL-28 CTRP2 6.9474 7.6968 5.7961 0.1554
Hs 839.T CTRP2 6.9953 12.3478 3.6458 8.3658
HMCB CTRP2 7.0291 8.5458 5.4877 0.9897
WM1799 CTRP2 7.093 10.2483 4.7391 3.762
UACC-62 CTRP2 7.3595 8.333 5.7261 0.1479
G-361 CTRP2 7.3877 11.2779 4.4447 4.5291
IGR-39 CTRP2 7.4167 9.3037 5.3664 1.0542
SK-MEL-30 CTRP2 7.4744 10.074 5.0596 2.0596
RVH-421 CTRP2 7.5546 9.8467 5.2054 1.4675
SK-MEL-5 CTRP2 7.6942 11.1712 4.6906 3.1833
SK-MEL-3 CTRP2 7.7167 8.8773 5.6673 0.1453
IGR-37 CTRP2 7.7364 9.4718 5.4519 0.5841
WM793 CTRP2 7.741 11.7938 4.4307 4.1208
Hs 936.T CTRP2 7.7769 9.2911 5.5394 0.3573
Hs 895.T CTRP2 7.7966 9.6831 5.3953 0.6986
WT2-iPS CTRP2 7.9362 13.6161 3.6954 6.7389
Mel JuSo CTRP2 7.9749 9.4027 5.5775 0.2164
IPC-298 CTRP2 7.9777 9.088 5.6886 0.0726
COLO 800 CTRP2 8.0365 12.5694 4.2549 4.4306
COLO 829 CTRP2 8.0519 10.5681 5.1555 1.2189
K029AX CTRP2 8.0593 12.7141 4.2019 4.6056
SK-MEL-31 CTRP2 8.0624 13.3381 3.911 5.7251
MDA-MB-435S CTRP2 8.1011 12.9273 4.1287 4.8342
CJM [Human melanoma] CTRP2 8.1567 13.3485 3.9669 5.3869
UACC-257 CTRP2 8.6425 15.7494 3.1488 7.882
WM983B CTRP2 8.9082 11.1347 5.3125 0.3885
COLO 792 CTRP2 8.9436 16.3843 3.0449 7.8737
SK-MEL-2 CTRP2 9.1066 24.9118 -0.9749 20.3588
Hs 294T CTRP2 10.5827 18.6546 2.9994 6.1267
WM88 CTRP2 10.7138 19.6217 2.6394 7.2087
IGR-1 CTRP2 11.0195 24.4898 0.5654 13.4729
HT-144 CTRP2 12.0546 22.4212 2.1564 7.3901
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 18 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KE-39 CTRP2 4.9238 8.9177 3.5928 12.6875
SNU-601 CTRP2 6.5207 8.1784 5.3435 2.1437
HuG1-N CTRP2 7.024 12.394 3.6444 8.3242
SNU-16 CTRP2 7.7294 13.4651 3.6271 7.3031
IM95 CTRP2 7.9306 32.1777 -5.4856 30.549
OCUM-1 CTRP2 8.0101 9.9982 5.3671 1.3959
HGC-27 CTRP2 8.0137 9.7849 5.4514 0.4475
SNU-216 CTRP2 8.015 9.6309 5.5098 0.3251
SNU-1 CTRP2 8.0522 12.5824 4.2587 4.397
ECC10 CTRP2 8.3632 9.818 5.5756 0.1309
MKN74 CTRP2 8.439 10.6682 5.2944 0.6097
NUGC-3 CTRP2 8.4909 10.0019 5.558 0.1288
LMSU CTRP2 9.1289 10.804 5.5093 0.0881
SH-10-TC CTRP2 9.7121 15.0986 4.0849 3.2932
MKN7 CTRP2 10.3573 20.6761 1.9346 10.0018
Hs 746.T CTRP2 12.8169 27.2137 0.4301 11.7412
SNG-M CTRP2 8.5531 10.0239 5.5726 0.1039
SNU-685 CTRP2 11.4852 20.0239 2.8989 5.5725
⏷ Show the Full List of 18 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
FTC-133 CTRP2 7.3815 10.8797 4.6296 3.8065
TT2609-C02 CTRP2 7.5651 15.5575 2.488 12.0014
ML-1 [Human leukemia] CTRP2 7.8874 9.6574 5.4462 0.5187
SW579 CTRP2 8.1063 14.0327 3.6103 6.8369
FTC-238 CTRP2 9.0586 17.171 2.748 8.8181
Cancer Drug Sensitivity Data Curated from 19 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BICR 18 CTRP2 6.4172 10.4025 4.1677 7.1953
SCC-25 CTRP2 6.4592 11.2722 3.7676 8.7861
BICR 22 CTRP2 7.0981 11.7795 4.0005 6.7508
BICR 16 CTRP2 7.1135 9.6738 5.0245 2.6095
PE/CA-PJ49 CTRP2 7.3758 9.8972 5.0819 2.0843
BICR 6 CTRP2 7.534 10.3884 4.9524 2.3876
FaDu CTRP2 7.6047 9.1498 5.5197 0.4836
SCC-4 CTRP2 7.9617 10.2863 5.2281 1.066
HSC-4 CTRP2 7.9676 9.3218 5.6037 0.1773
YD-8 CTRP2 8.07 9.9006 5.4311 0.4678
BICR 56 CTRP2 8.0779 9.4795 5.5892 0.1718
CAL-33 CTRP2 8.1032 9.9483 5.4269 0.4623
PE/CA-PJ41 (clone D2) CTRP2 8.2407 9.7954 5.5382 0.2069
BICR 31 CTRP2 8.3102 14.2425 3.6449 6.4293
CAL-27 CTRP2 8.4108 9.5402 5.6855 0.0341
PE/CA-PJ15 CTRP2 10.9017 22.081 1.6221 10.3625
PE/CA-PJ34 (clone C12) CTRP2 10.9698 21.4218 1.9698 9.1536
HSC-2 CTRP2 11.1098 20.979 2.2571 8.0524
SCC-9 CTRP2 11.5708 22.687 1.7532 9.1725
⏷ Show the Full List of 19 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 12 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KMBC-2 CTRP2 3.7317 7.7608 2.9085 18.4428
647V CTRP2 6.447 10.2052 4.2892 6.6348
SCaBER CTRP2 7.3048 11.2121 4.4205 4.741
HT-1376 CTRP2 7.3056 10.2104 4.8952 2.8696
RT-4 CTRP2 7.5916 14.0406 3.2508 9.0023
RT-112 CTRP2 7.7312 11.081 4.7543 2.902
HT-1197 CTRP2 8.4961 10.0159 5.555 0.1312
UM-UC-1 CTRP2 8.6835 13.5133 4.2126 3.8487
BC-3C CTRP2 8.685 19.8031 1.2223 14.6906
T24 CTRP2 8.755 16.0538 3.0783 7.9971
U-BLC1 CTRP2 8.7799 10.5262 5.4809 0.1668
UM-UC-3 CTRP2 10.5421 18.56 3.0185 6.104
⏷ Show the Full List of 12 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HeLa CTRP2 7.4582 8.7055 5.6279 0.301

References

1 ClinicalTrials.gov (NCT04459715) A Study of Debio 1143 (Xevinapant) in Combination With Platinum-Based Chemotherapy and Standard Fractionation Intensity-Modulated Radiotherapy in Participants With Locally Advanced Squamous Cell Carcinoma of the Head and Neck, Suitable for Definitive Chemoradiotherapy. U.S. National Institutes of Health.
2 Small molecules, big targets: drug discovery faces the protein-protein interaction challenge.Nat Rev Drug Discov. 2016 Aug;15(8):533-50.
3 ClinicalTrials.gov (NCT02022098) Debio 1143-201 Dose-finding and Efficacy Phase I/II Trial. U.S. National Institutes of Health.
4 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7729).
5 Debio 1143, an antagonist of multiple inhibitor-of-apoptosis proteins, activates apoptosis and enhances radiosensitization of non-small cell lung c... Am J Cancer Res. 2014 Nov 19;4(6):943-51.