Details of the Drug

General Information of Drug (ID: DMVVWC8)

Drug Name

TBAJ-876

Synonyms

TBAJ-876; CHEMBL4553146; (1R,2S)-1-(6-bromo-2-methoxyquinolin-3-yl)-2-(2,6-dimethoxypyridin-4-yl)-4-(dimethylamino)-1-(2,3,6-trimethoxypyridin-4-yl)butan-2-ol; OYN1GF5B1M; BDBM50537234; HY-128866; CS-0101568; (1R)-1-(6-Bromo-2-methoxyquinolin-3-yl)-2-(2,6-dimethoxypyridin-4-yl)-4-(dimethylamino)-1-(2,3,6-trimethoxypyridin-4-yl)butan-2-ol; 3-QUINOLINEETHANOL, 6-BROMO-.ALPHA.-(2,6-DIMETHOXY-4-PYRIDINYL)-.ALPHA.-(2-(DIMETHYLAMINO)ETHYL)-2-METHOXY-.BETA.-(2,3,6-TRIMETHOXY-4-PYRIDINYL)-, (.ALPHA.S,.BETA.R)-

Indication

Disease Entry	ICD 11	Status	REF
Pulmonary tuberculosis	1B10.Z	Phase 1	[1]
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Drug Type

Small molecule

Structure

3D MOL

2D MOL

Chemical Identifiers

Formula: C31H37BrN4O7
Canonical SMILES: CN(C)CCC(C1=CC(=NC(=C1)OC)OC)(C(C2=CC(=NC(=C2OC)OC)OC)C3=C(N=C4C=CC(=CC4=C3)Br)OC)O
InChI: InChI=1S/C31H37BrN4O7/c1-36(2)12-11-31(37,19-15-24(38-3)34-25(16-19)39-4)27(21-17-26(40-5)35-30(43-8)28(21)41-6)22-14-18-13-20(32)9-10-23(18)33-29(22)42-7/h9-10,13-17,27,37H,11-12H2,1-8H3/t27-,31-/m1/s1
InChIKey: HHDDKDPLFXIPBX-DLFZDVPBSA-N

Cross-matching ID

PubChem CID: 155510360
TTD ID: DYT06V

References

1	ClinicalTrials.gov (NCT04493671) A Phase 1, Partially Blind, Placebo Controlled, Randomized, Combined Single Ascending Dose With a Food Effect Cohort and Multiple Ascending Dose Study Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of TBAJ-876 in Healthy Adult Subjects. U.S.National Institutes of Health.