Details of the Drug

General Information of Drug (ID: DMVXW4L)

Drug Name
MYRIOCIN
Synonyms
Myriocin; thermozymocidin; 35891-70-4; ISP-I; ISP-1; UNII-YRM4E8R9ST; (2S,3R,4R,6E)-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic acid; YRM4E8R9ST; Myriocin, Mycelia sterilia; Myriocin from Mycelia sterilia; CHEBI:582124; NCGC00163597-02; NCGC00163597-03; DSSTox_CID_26360; DSSTox_RID_81561; (2S,3R,4R,6E)-2-amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxoicos-6-enoic acid; DSSTox_GSID_46360; [2S,3R,4R]-(E)-2-Amino-3,4-dihydroxy-2-[hydroxymethyl]-14-oxo-6-eicosenoic Acid
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 1 Molecular Weight (mw) 401.5
Logarithm of the Partition Coefficient (xlogp) -0.1
Rotatable Bond Count (rotbonds) 18
Hydrogen Bond Donor Count (hbonddonor) 5
Hydrogen Bond Acceptor Count (hbondacc) 7
Chemical Identifiers
Formula
C21H39NO6
IUPAC Name
(E,2S,3R,4R)-2-amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxoicos-6-enoic acid
Canonical SMILES
CCCCCCC(=O)CCCCCC/C=C/C[C@H]([C@@H]([C@@](CO)(C(=O)O)N)O)O
InChI
InChI=1S/C21H39NO6/c1-2-3-4-10-13-17(24)14-11-8-6-5-7-9-12-15-18(25)19(26)21(22,16-23)20(27)28/h9,12,18-19,23,25-26H,2-8,10-11,13-16,22H2,1H3,(H,27,28)/b12-9+/t18-,19+,21+/m1/s1
InChIKey
ZZIKIHCNFWXKDY-GNTQXERDSA-N
Cross-matching ID
PubChem CID
6438394
ChEBI ID
CHEBI:582124
CAS Number
35891-70-4
TTD ID
D07MQF

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
RAC-alpha serine/threonine-protein kinase (AKT1) TTWTSCV AKT1_HUMAN Inhibitor [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
RAC-alpha serine/threonine-protein kinase (AKT1) DTT AKT1 2.63E-29 0.65 1.45
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MHH-NB-11 CTRP2 6.4695 15.4631 0.9698 14.078
SiMa CTRP2 7.8234 9.7429 4.4209 0.2369
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-308 CTRP2 6.1185 7.8594 4.3991 1.2106
HuH-28 CTRP2 6.7993 8.3304 4.5339 0.3598
SNU-1196 CTRP2 6.9478 8.1943 4.6413 0.1297
HuCC-T1 CTRP2 6.9611 9.3388 4.206 1.1327
SNU-478 CTRP2 7.149 8.9335 4.4516 0.3909
SNU-1079 CTRP2 9.6218 25.1903 -1.516 17.0086
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U2OS CTRP1 7.4375 10.2751 4.0652 2.7019
SW1353 CTRP2 10.7853 20.6321 1.3553 7.0281
MHH-ES-1 CTRP2 12.2159 25.2542 0.1055 9.4005
Cancer Drug Sensitivity Data Curated from 13 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KPL-1 CTRP2 5.3824 7.7703 3.9519 3.9797
MCF-7 CTRP2; CTRP1 6.4855 8.6751 4.2557 1.421
HCC1954 CTRP2 6.5979 19.5662 -0.9659 20.1128
CAMA-1 CTRP2 6.6154 8.1744 4.5149 0.4901
CAL-120 CTRP2 6.6246 8.0459 4.5685 0.3591
CAL-148 CTRP2 6.6526 8.192 4.5243 0.448
HCC1806 CTRP2 6.803 8.9061 4.3076 0.9423
HDQ-P1 CTRP2 6.9848 13.8879 2.1168 8.932
HCC1937 CTRP2 7.173 9.6312 4.1884 1.0363
CAL-51 CTRP2 7.3838 9.0075 4.5167 0.2034
HCC1395 CTRP2 7.3955 9.0663 4.5003 0.225
JIMT-1 CTRP2 7.4391 8.857 4.5892 0.1039
HCC1569 CTRP2 7.4416 9.6642 4.297 0.6023
⏷ Show the Full List of 13 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Tongue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-38 CTRP2 6.8504 7.9726 4.683 0.0977
Cancer Drug Sensitivity Data Curated from 17 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-489 CTRP2 5.7116 7.5757 4.2823 2.1213
CAS-1 CTRP2 5.7167 9.4676 3.365 5.8617
LN-18 CTRP2 6.1186 7.0117 4.7485 0.1861
NMC-G1 CTRP2 6.1413 7.941 4.3758 1.2701
SNU-626 CTRP2 6.2627 8.7875 4.0644 2.2768
GB-1 CTRP2 6.4187 12.2301 2.5225 8.1881
SNU-466 CTRP2 6.5707 7.8158 4.6328 0.2471
SNU-1105 CTRP2 6.6682 8.1051 4.5644 0.3493
SF295 CTRP2 6.7201 7.8966 4.6616 0.1527
GaMG CTRP1 6.8139 10.6067 3.5754 7.4601
ONS-76 CTRP2 6.8485 8.3682 4.5399 0.3275
U-87MG ATCC CTRP2 7.006 8.4761 4.563 0.2315
LN-229 CTRP2; CTRP1 7.2154 8.9481 4.4871 0.3302
SNU-738 CTRP2 7.216 15.7928 1.3549 11.4683
SF126 CTRP2 7.3688 9.1194 4.4709 0.2795
Daoy CTRP2 7.4345 8.8929 4.5753 0.1191
SNU-201 CTRP2 10.8247 23.6706 -0.0055 11.2239
⏷ Show the Full List of 17 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HEC-265 CTRP2 -7.1423 -4.8174 -7.1424 80.7171
KLE CTRP2; CTRP1 6.0022 8.7175 3.9434 3.147
HEC-6 CTRP2 6.3785 7.974 4.4855 0.7148
HEC-59 CTRP2; CTRP1 6.515 8.0468 4.5338 0.5417
HEC-108 CTRP2; CTRP1 6.9395 11.5708 3.205 4.813
JHUEM-2 CTRP1 7.2352 9.2362 4.3868 1.1404
HEC-1-B CTRP2 7.3581 8.9701 4.5203 0.2044
HEC-151 CTRP1 7.8643 16.0408 1.6933 16.8178
RL95-2 CTRP2 10.1097 20.718 0.9188 9.1594
Ishikawa (Heraklio) 02 ER- CTRP2; CTRP1 6.1296 7.2178 4.6879 0.3592
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 45 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KMS-21-BM CTRP2 -3.9116 13.1581 -7.7144 54.3268
NU-DUL-1 CTRP1 5.0466 6.5484 4.3039 6.8559
KMS-26 CTRP2 5.5556 9.2352 3.3583 6.1587
KE-37 CTRP2 5.9232 12.4968 2.0228 11.0042
SKM-1 CTRP1 5.9538 8.9785 3.7854 8.1972
SU-DHL-1 CTRP2 6.1487 7.4763 4.5789 0.6001
P31/FUJ CTRP2 6.2062 7.5422 4.5795 0.5591
MOLM-13 CTRP2 6.2953 12.5859 2.2586 9.4404
BL-70 CTRP1 6.3355 7.4057 4.7039 0.4885
LP-1 CTRP1 6.3771 8.799 4.1396 4.1526
DEL CTRP2 6.4034 14.1436 1.5717 11.9505
CML-T1 CTRP2 6.4488 8.1676 4.4398 0.8007
JURL-MK1 CTRP2 6.5475 10.5392 3.4259 4.3886
P12-Ichikawa CTRP2 6.5553 9.8884 3.7358 3.1767
AMO1 CTRP1 6.566 7.7835 4.6569 0.505
SU-DHL-5 CTRP1 6.6 7.7447 4.6844 0.3767
THP-1 CTRP1 6.6747 10.9091 3.3459 9.5793
MOLM-16 CTRP1 6.765 8.724 4.3774 1.7523
KMS-27 CTRP2 6.8035 8.1545 4.6008 0.2279
HT CTRP2 6.9688 8.2186 4.6406 0.1265
RPMI-8402 CTRP2 6.9879 8.3055 4.6171 0.1533
Peer CTRP2 7.0228 8.317 4.626 0.1341
EM-2 CTRP2 7.102 15.2809 1.5231 11.019
ALL-SIL CTRP2 7.1152 8.7948 4.4895 0.3283
KE-97 CTRP2 7.1361 8.5787 4.5759 0.1772
KMM-1 CTRP2 7.1499 15.7264 1.3402 11.6239
NOMO-1 CTRP1 7.1579 16.2245 1.114 21.5886
KMS-11 CTRP1 7.1619 12.9911 2.6787 12.9445
WSU-DLCL2 CTRP2; CTRP1 7.1864 8.1835 4.7422 0.0277
U-937 CTRP1 7.2597 8.7479 4.5764 0.3683
RPMI-8226 CTRP1 7.2618 9.5363 4.2815 1.6617
SU-DHL-4 CTRP1 7.3533 8.4893 4.6975 0.0868
NCI-H929 CTRP2 7.4062 8.873 4.572 0.1274
Jurkat CTRP2 7.4186 8.6708 4.645 0.0585
HDLM-2 CTRP2 7.4223 9.2586 4.4412 0.3145
NCO2 CTRP2 7.452 9.2719 4.4479 0.2936
EJM CTRP1 7.4579 9.1638 4.5033 0.4934
EHEB CTRP2 7.5528 9.2043 4.5102 0.1748
GDM-1 CTRP1 7.603 16.1616 1.4581 18.7094
OCI-AML-3 CTRP1 7.8749 27.9741 -4.1449 33.5712
PL21 CTRP1 7.9585 15.14 2.1814 13.8976
PF-382 CTRP2 8.2674 9.8885 4.5283 0.0619
OCI-Ly10 CTRP1 8.6433 19.8357 0.4021 20.6673
Ki-JK CTRP2 9.2643 26.0569 -2.1865 19.1971
NALM-6 CTRP2 10.8099 22.5225 0.5147 9.6552
⏷ Show the Full List of 45 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TUHR4TKB CTRP2 6.4132 12.8967 2.1924 9.5144
OS-RC-2 CTRP2 6.6221 11.876 2.8373 6.6227
RCC10RGB CTRP1 6.8651 8.5475 4.4928 0.988
BFTC-909 CTRP2 7.0063 8.5833 4.5239 0.3011
KMRC-20 CTRP2 7.1304 9.5019 4.2209 0.972
SNU-1272 CTRP2 10.0908 24.9877 -1.0999 15.2709
769-P CTRP2 11.548 24.4001 0.0994 10.1093
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 34 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-C4 CTRP1 -1.6332 50.8613 -23.6333 53.3294
MDST8 CTRP1 6.257 8.1589 4.3568 2.7635
SW48 CTRP2 6.3726 10.6695 3.247 5.3405
DLD-1 CTRP2 6.3971 7.5479 4.6619 0.2542
OUMS-23 CTRP2 6.4925 8.6459 4.2592 1.3421
HT-55 CTRP1 6.5908 8.0973 4.5479 0.9963
COLO 320 CTRP1 6.6 14.2123 1.6944 20.4756
CL-34 CTRP1 6.6111 8.4115 4.4315 1.6401
HCT 8 CTRP1 6.6841 7.7135 4.7269 0.2053
LS411N CTRP2 6.6996 8.0863 4.5845 0.2946
CL-40 CTRP1 6.7327 14.5017 1.6494 20.2898
SNU-1040 CTRP1 6.7812 7.9388 4.6838 0.2809
LS513 CTRP2 6.8223 8.1866 4.5965 0.2296
HCT 116 CTRP1 6.8562 8.5441 4.4903 1.0095
LoVo CTRP1 6.9417 9.6592 4.0735 3.4738
LS123 CTRP1 6.9726 12.7365 2.674 13.5131
KM12 CTRP1 6.9939 8.7189 4.482 0.9151
COLO205 CTRP2 7.1645 8.5436 4.5987 0.1403
RKO CTRP1 7.1763 9.0633 4.4279 1.0002
SK-CO-1 CTRP2 7.2214 8.7849 4.5347 0.2173
NCI-H508 CTRP1 7.2639 8.5921 4.632 0.2221
HT-29 CTRP2; CTRP1 7.2864 8.3449 4.7226 0.0313
SNU-81 CTRP1 7.2958 8.9648 4.5127 0.5562
SNU-C5 CTRP1 7.4181 9.6282 4.3146 1.3135
HT115 CTRP2; CTRP1 7.4784 8.5425 4.7216 0.0217
SNU-175 CTRP1 7.4939 9.0419 4.5595 0.3126
RCM-1 [Human ESC] CTRP1 7.5031 9.1527 4.5241 0.4058
SNU-61 CTRP1 7.5462 9.1455 4.5425 0.3356
LS180 CTRP2; CTRP1 7.5777 21.3308 -1.0852 18.8794
SW948 CTRP1 7.7046 16.1325 1.5416 18.0179
CW-2 CTRP1 7.7942 9.5175 4.5033 0.3374
SW480 CTRP1 7.991 9.9245 4.4333 0.4411
SW620 CTRP1 8.0396 9.7245 4.5195 0.2223
COLO 678 CTRP1 8.4593 17.8529 1.2255 17.6126
⏷ Show the Full List of 34 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHH-6 CTRP1 6.3053 7.0622 4.8155 0.1303
SNU-878 CTRP2 6.7804 8.5967 4.4223 0.6361
Hep 3B2.1-7 CTRP2 6.8345 8.2773 4.5681 0.2774
Hep-G2 CTRP1 7.2173 8.4615 4.6601 0.1769
SNU-398 CTRP1 7.4364 14.2868 2.2442 14.9044
Li-7 CTRP2 7.7299 33.8149 -7.1686 30.3146
SNU-449 CTRP1 10.027 30.2498 -3.6746 28.703
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 75 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H1435 CTRP1 4.239 14.3944 -0.3086 36.4854
NCI-H1963 CTRP1 4.2468 7.736 2.9952 21.8028
COLO 668 CTRP1 4.6125 8.3001 3.0527 19.5391
NCI-H1694 CTRP1 5.6665 7.6412 4.2323 5.2768
COR-L51 CTRP1 5.9147 7.8732 4.2849 4.1254
NCI-H526 CTRP2 5.9595 7.6919 4.3832 1.4314
NCI-H1836 CTRP1 6.0557 8.034 4.2971 3.6714
MOR/CPR CTRP2 6.0844 7.4259 4.568 0.6803
SCLC-21H CTRP1 6.2059 8.0022 4.3974 2.5668
RERF-LC-Ad1 CTRP2 6.2337 7.3469 4.6695 0.3083
LCLC-103H CTRP2 6.2408 7.5246 4.6028 0.4725
NCI-H1581 CTRP2 6.273 8.3239 4.28 1.4772
BEN CTRP2 6.3117 7.1388 4.777 0.0851
NCI-H460 CTRP2; CTRP1 6.492 8.5828 4.2992 1.2686
HCC1588 CTRP2 6.5254 8.5315 4.3256 1.0962
NCI-H2291 CTRP2 6.6379 8.5051 4.3926 0.8077
HCC1359 CTRP1 6.6493 7.529 4.7776 0.1067
NCI-H650 CTRP2 6.7493 9.9977 3.803 2.7018
NCI-H1155 CTRP2 6.7705 8.6786 4.3849 0.7429
RERF-LC-KJ CTRP1 6.7756 8.2863 4.5545 0.7773
HCC95 CTRP2 6.7804 8.5905 4.4248 0.6296
NCI-H841 CTRP1 6.7896 9.0423 4.2576 2.4815
NCI-H1838 CTRP2 6.7946 8.815 4.3409 0.8511
COR-L23 CTRP1 6.7951 8.2141 4.5896 0.607
Sq-1 CTRP1 6.8718 8.2615 4.6027 0.5001
NCI-H727 CTRP2 6.8764 9.0948 4.2655 1.0152
HCC366 CTRP2 6.9088 9.7632 3.9978 1.8483
NCI-H2141 CTRP1 6.9221 8.1122 4.6748 0.2443
NCI-H1781 CTRP1 6.9886 14.5504 1.8093 18.6616
HCC4006 CTRP1 7.085 9.3845 4.2606 2.0122
NCI-H69 CTRP2 7.109 8.9512 4.4283 0.4567
T3M-10 CTRP1 7.1266 10.2799 3.9036 4.3194
NCI-H1930 CTRP1 7.1278 8.5342 4.6027 0.3539
HCC78 CTRP2 7.1394 8.7385 4.5198 0.2651
NCI-H1915 CTRP1 7.1459 9.1815 4.3693 1.3221
NCI-H3255 CTRP1 7.159 8.7284 4.5452 0.5255
HCC2935 CTRP1 7.1888 9.2187 4.3736 1.2538
NCI-H1105 CTRP1 7.1984 8.8989 4.4984 0.6756
HCC1195 CTRP1 7.2091 8.5277 4.6346 0.2351
NCI-H358 CTRP2 7.2138 11.2522 3.5078 3.2789
NCI-H2122 CTRP1 7.2161 8.4321 4.6697 0.1588
NCI-H1734 CTRP2 7.2342 9.7171 4.1826 1.0128
NCI-H2172 CTRP1 7.2759 8.9977 4.4929 0.6424
NCI-H196 CTRP2 7.2809 16.8721 0.875 13.0974
NCI-H2081 CTRP1 7.3013 9.0998 4.4655 0.7319
NCI-H596 CTRP1 7.3199 9.1545 4.4527 0.7698
CAL-12T CTRP2; CTRP1 7.3416 9.7516 4.2322 0.8585
NCI-H2286 CTRP1 7.3558 8.746 4.612 0.2364
NCI-H211 CTRP2 7.3672 13.0072 2.7923 5.7898
SHP-77 CTRP2 7.3705 8.5529 4.6678 0.0472
NCI-H2023 CTRP1 7.459 9.301 4.4542 0.6648
NCI-H1299 CTRP2 7.4801 11.7024 3.4594 3.1741
LXF 289 CTRP1 7.5311 11.4242 3.6238 5.4822
NCI-H1876 CTRP1 7.5824 9.6418 4.378 0.8768
NCI-H1755 CTRP1 7.5919 9.4039 4.4684 0.5337
NCI-H441 CTRP1 7.6214 9.5504 4.427 0.6594
HCC827 CTRP2; CTRP1 7.6392 18.1318 0.5281 13.8031
NCI-H2342 CTRP1 7.705 9.5884 4.4454 0.5462
NCI-H2030 CTRP2; CTRP1 7.7314 9.7458 4.3989 0.322
SK-LU-1 CTRP1 7.8504 9.8656 4.4015 0.6098
HCC1833 CTRP2; CTRP1 8.1623 15.8246 1.9904 7.8584
NCI-H2110 CTRP1 8.3325 10.6745 4.2956 0.6891
NCI-H2009 CTRP2 8.7953 24.115 -1.5745 18.3148
NCI-H2405 CTRP2 8.9086 18.4537 1.2216 9.5885
HCC44 CTRP2 9.7623 47.5681 -12.425 33.1866
COLO 699 CTRP2; CTRP1 10.8493 27.3391 -1.7037 15.9559
NCI-H292 CTRP2 11.622 30.4654 -2.6908 17.3611
NCI-H2073 CTRP1 11.6371 23.6168 0.5195 14.188
HCC2279 CTRP2 12.0352 32.0359 -3.1641 17.9323
HARA [Human squamous cell lung carcinoma] CTRP2 12.2789 23.4407 0.9459 6.8781
A-549 CTRP2 12.5276 24.9413 0.423 8.1796
Lu-99 CTRP2 13.3464 29.8093 -1.294 12.0677
HCC15 CTRP2; CTRP1 13.7009 27.5079 -0.0446 8.4684
HCC1171 CTRP2 13.7629 31.4327 -1.7862 12.8762
HCC2108 CTRP2; CTRP1 14.1264 32.4075 -2.0012 13.0741
⏷ Show the Full List of 75 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE-9 CTRP2 6.8334 8.4283 4.511 0.3948
KYSE-180 CTRP2 6.8708 9.5526 4.0688 1.6433
COLO 680N CTRP2 7.3271 9.2625 4.4014 0.424
TE-10 CTRP2 7.4688 9.1477 4.4989 0.2089
KYSE-140 CTRP2 12.5851 32.3014 -2.9287 16.7904
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OVMANA CTRP1 5.87 8.4316 3.9912 6.7178
OVISE CTRP2 6.1477 12.3515 2.2646 9.6575
Kuramochi CTRP2 6.3794 8.8761 4.0936 2.0375
COV318 CTRP1 6.3992 7.4095 4.7279 0.3468
ES2 CTRP2 6.4589 7.6788 4.6382 0.2788
SNU-8 CTRP2 6.5565 8.0138 4.5516 0.4304
OAW42 CTRP1 6.6232 7.7189 4.7025 0.3027
COV362 CTRP1 6.6651 13.2013 2.2362 17.2221
OVK18 CTRP1 6.6788 11.8169 2.916 12.7224
OVSAHO CTRP2 6.8623 8.9864 4.3033 0.9142
JHOS-4 CTRP1 6.8974 12.4386 2.7659 13.1143
OV7 CTRP1 6.9561 9.8381 4.0037 3.9403
Caov-3 CTRP1 6.9627 8.7266 4.4658 1.0233
DOV13 CTRP2 6.9835 8.4837 4.5515 0.2583
ONCO-DG-1 CTRP2 7.2807 8.7163 4.5809 0.1397
JHOM-1 CTRP1 7.3015 15.094 1.765 17.982
OVKATE CTRP1 7.3267 30.3108 -5.7305 36.6696
OVTOKO CTRP2 7.4293 12.6885 2.9798 4.9999
IGROV-1 CTRP1 7.4781 10.9149 3.8164 4.26
COV644 CTRP1 7.5156 14.1256 2.3731 13.9133
COV434 CTRP1 7.5829 10.2497 4.1441 2.035
OVCAR-8 CTRP1 7.7285 14.7042 2.2383 14.1569
EFO-27 CTRP1 7.7426 9.5458 4.4746 0.4372
A2780 CTRP1 7.8158 9.6113 4.4786 0.3931
OV-90 CTRP1 7.835 9.4249 4.5496 0.2205
TYK-nu CTRP1 7.9433 9.7928 4.4618 0.3845
RMG-I CTRP1 8.4088 21.413 -0.5225 24.4564
RMUG-S CTRP1 8.4127 23.3999 -1.489 27.1921
OVCAR-4 CTRP1 8.7175 21.4778 -0.3377 23.1408
SNU-840 CTRP1 10.3041 21.6242 0.6323 16.1653
JHOC-5 CTRP2; CTRP1 18.0117 34.8386 -0.9243 7.3168
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SUIT-2 CTRP2 6.453 9.852 3.6886 3.4843
QGP-1 CTRP2 6.5415 8.2482 4.4514 0.7031
PaTu 8902 CTRP1 6.8405 8.1952 4.6146 0.4765
CFPAC-1 CTRP2 6.8554 8.5277 4.4824 0.449
KP-4 CTRP2 6.8769 8.5274 4.4917 0.4184
HPAF-II CTRP2 6.8817 9.8243 3.9562 2.0168
BxPC-3 CTRP2 7.6153 23.8453 -2.3089 21.9324
SNU-213 CTRP2 9.8606 22.7214 -0.1747 12.901
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ACC-MESO-1 CTRP2 6.1513 7.3332 4.6383 0.4307
NCI-H28 CTRP2 6.3453 8.4225 4.2767 1.4182
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PaCa-3 CTRP1 10.6748 22.6079 0.4057 16.3501
22Rv1 CTRP2 11.5731 28.3405 -1.7157 15.0716
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-15 CTRP2 10.5091 22.4994 0.3417 10.5317
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-MEL-1 CTRP2; CTRP1 5.7682 7.2669 4.4751 1.3741
RPMI-7951 CTRP2 5.7803 8.1463 4.0556 2.932
SK-MEL-28 CTRP1 6.1679 7.1573 4.728 0.526
COLO 741 CTRP2 7.0901 20.4198 -1.0121 19.4126
SK-MEL-5 CTRP1 7.1791 8.5083 4.6305 0.2559
A-375 CTRP2; CTRP1 7.282 8.8139 4.5614 0.1875
Hs 852.T CTRP1 7.4487 8.9891 4.5614 0.326
Mel Ho CTRP2 11.2704 22.2813 0.8951 7.9889
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RKN CTRP1 6.9214 7.9911 4.7162 0.15
HT-1080 CTRP1 7.1073 8.8518 4.479 0.8283
Rh41 CTRP2 12.7687 33.7973 -3.5166 17.8535
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MKN45 CTRP2 6.2505 7.2819 4.7014 0.2307
SNU-620 CTRP2 6.2981 8.7005 4.1253 2.0097
ECC12 CTRP2 6.3365 7.5527 4.6345 0.341
SNU-668 CTRP2 6.4367 8.9026 4.1149 1.8993
23132/87 CTRP2 6.6699 13.7285 1.9712 9.9777
SNU-5 CTRP2 7.0032 8.296 4.6261 0.1379
NUGC-4 CTRP2 7.0732 16.2481 1.0302 12.8713
MKN1 CTRP2 7.0864 9.533 4.187 1.0996
NCI-N87 CTRP2 7.0979 9.2483 4.3078 0.7544
GSS CTRP2 7.1447 8.3908 4.6444 0.092
AGS CTRP2; CTRP1 7.2436 8.5652 4.6341 0.1045
MKN74 CTRP1 7.252 9.4432 4.3138 1.4969
KE-39 CTRP2 10.4103 20.5893 1.1576 8.0516
SNU-719 CTRP2 11.9638 28.9812 -1.7659 14.747
SNU-1077 CTRP2 6.5735 11.8183 2.8316 6.716
SNG-M CTRP1 7.0584 10.5319 3.7544 5.5393
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
8305C CTRP2 6.2378 8.1168 4.3518 1.2608
BHT-101 CTRP2 6.4147 14.2932 1.5064 12.1805
B-CPAP CTRP2 6.6989 8.2127 4.5363 0.398
CAL-62 CTRP2 6.7746 7.9781 4.6532 0.1518
CGTH-W-1 CTRP2 6.8467 8.4099 4.5236 0.3621
TT CTRP2 7.7284 15.3368 1.9264 8.6018
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-10B CTRP2 6.7731 8.1629 4.5857 0.2655
HSC-3 CTRP2 6.8947 8.1478 4.6381 0.1453
SNU-899 CTRP2 7.0659 8.3099 4.6441 0.1047
BHY CTRP2 7.0918 10.4006 3.8187 2.2928
SNU-46 CTRP2 7.1572 11.9987 3.1307 4.7572
SNU-1214 CTRP2 7.2976 9.4231 4.3279 0.5988
SCC-9 CTRP1 7.3349 9.2096 4.4384 0.8179
SNU-1066 CTRP2 7.4087 14.8234 1.9573 8.9297
Detroit 562 CTRP2 7.64 16.6361 1.2432 11.241
SNU-1041 CTRP2 11.7994 30.1834 -2.4396 16.5706
SNU-1076 CTRP2 12.1417 25.4326 -0.0184 9.8324
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
253J CTRP2 6.534 10.7568 3.3139 4.849
639V CTRP2 6.6738 7.7248 4.705 0.1039
KU-19-19 CTRP2 6.8248 8.0902 4.6323 0.1705
JMSU-1 CTRP2 6.8598 8.3385 4.5556 0.2923
TCCSUP CTRP2 6.991 9.2521 4.2563 0.963
BFTC-905 CTRP2 7.1564 8.3082 4.6764 0.0616
253J-BV CTRP2 7.361 16.1053 1.3054 11.4298
CAL-29 CTRP2 7.413 15.9662 1.4093 10.9714
VM-CUB-1 CTRP2 7.9747 9.5399 4.5448 0.077
5637 CTRP2 12.2158 34.5648 -4.2516 19.9561
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6664).
2 Raft nanodomains contribute to Akt/PKB plasma membrane recruitment and activation. Nat Chem Biol. 2008 Sep;4(9):538-47.