Details of the Drug

General Information of Drug (ID: DMW180Y)

Drug Name

Glycinamide Ribonucleotide

Synonyms

Glycineamide ribonucleotide; Glycineamideribotide; glycinamide ribonucleotide; 10074-18-7; 5'-phosphoribosylglycineamide; GAR; 5'-phosphoribosylglycinamide; N1-(5-Phospho-D-ribosyl)glycinamide; {[(2R,3S,4R,5R)-5-(2-aminoacetamido)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid; N1-(5-phospho-beta-D-ribosyl)glycinamide; Glycineamide ribotide; AC1Q5JNA; AC1L4OGM; n-glycyl-5-o-phosphono-; A-d-ribofuranosylamine; 5'-Phosphoribosyl-glycineamide; SCHEMBL4366354; BDBM22589; DTXSID70143478; C03838

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

#Ro5 Violations (Lipinski): 2

Molecular Weight (mw)

286.18

Logarithm of the Partition Coefficient (xlogp)

-6.8

Rotatable Bond Count (rotbonds)

Hydrogen Bond Donor Count (hbonddonor)

Hydrogen Bond Acceptor Count (hbondacc)

Chemical Identifiers

Formula: C7H15N2O8P
IUPAC Name: [(2R,3S,4R,5R)-5-[(2-aminoacetyl)amino]-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate
Canonical SMILES: C([C@@H]1[C@H]([C@H]([C@@H](O1)NC(=O)CN)O)O)OP(=O)(O)O
InChI: InChI=1S/C7H15N2O8P/c8-1-4(10)9-7-6(12)5(11)3(17-7)2-16-18(13,14)15/h3,5-7,11-12H,1-2,8H2,(H,9,10)(H2,13,14,15)/t3-,5-,6-,7-/m1/s1
InChIKey: OBQMLSFOUZUIOB-SHUUEZRQSA-N

Cross-matching ID

PubChem CID: 160913
CAS Number: 10074-18-7
DrugBank ID: DB02236
TTD ID: D07DGI

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glycinamide ribonucleotide formyltransferase (GART)	TTEXB9Z	PUR2_HUMAN	Inhibitor	[1]

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Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This Drug

References

1	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.