Details of the Drug

General Information of Drug (ID: DMW4GM2)

Drug Name
AZD5153
Synonyms
RSMYFSPOTCDHHJ-GOSISDBHSA-N; AZD-5153; 1869912-39-9; UNII-C7C7U6YEAO; C7C7U6YEAO; SCHEMBL17477306; MolPort-044-561-768; AZD 5153 [WHO-DD]; AZD 5153; EX-A1317; BCP20057; ZINC575441177; AKOS030627661; SB18713; AS-35242; J3.544.368A; (3r)-4-[2-[4-[1-(3-methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-piperidyl]phenoxy]ethyl]-1,3-dimethyl-piperazin-2-one; XNH; 2-Piperazinone, 4-(2-(4-(1-(3-methoxy-1,2,4-triazolo(4,3-b)pyridazin-6-yl)-4-piperidinyl)phenoxy)ethyl)-1,3-dimethyl-, (3R)-; (R)-4-(2-(4-(1-(3-methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)pipe
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 1 [1]
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 479.6
Logarithm of the Partition Coefficient (xlogp) 2.4
Rotatable Bond Count (rotbonds) 7
Hydrogen Bond Donor Count (hbonddonor) 0
Hydrogen Bond Acceptor Count (hbondacc) 8
Chemical Identifiers
Formula
C25H33N7O3
IUPAC Name
(3R)-4-[2-[4-[1-(3-methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperidin-4-yl]phenoxy]ethyl]-1,3-dimethylpiperazin-2-one
Canonical SMILES
C[C@@H]1C(=O)N(CCN1CCOC2=CC=C(C=C2)C3CCN(CC3)C4=NN5C(=NN=C5OC)C=C4)C
InChI
InChI=1S/C25H33N7O3/c1-18-24(33)29(2)14-15-30(18)16-17-35-21-6-4-19(5-7-21)20-10-12-31(13-11-20)23-9-8-22-26-27-25(34-3)32(22)28-23/h4-9,18,20H,10-17H2,1-3H3/t18-/m1/s1
InChIKey
RSMYFSPOTCDHHJ-GOSISDBHSA-N
Cross-matching ID
PubChem CID
118693659
CAS Number
1869912-39-9
UNII
C7C7U6YEAO
DrugBank ID
DB17018
TTD ID
D0PH9I

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Bromodomain-containing protein 4 (BRD4) TTRA6BO BRD4_HUMAN Inhibitor [1]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Solid tumour/cancer
ICD Disease Classification 2A00-2F9Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Bromodomain-containing protein 4 (BRD4) DTT BRD4 3.27E-01 0.02 0.04
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYSE-220 GDSC2 2.1774 8.5626 -0.3042 25.1491
ESO-26 GDSC2 2.7556 8.596 0.1993 20.7153
OACP4 C GDSC2 3.1849 9.3339 0.201 19.3358
FLO-1 GDSC2 3.7565 15.9381 -2.6277 28.4936
SK-GT-4 GDSC2 3.8966 16.7119 -2.9004 28.8622
OACM5.1 C GDSC2 4.2727 6.3807 2.4936 3.0394
ESO-51 GDSC2 4.6334 8.0092 1.9604 5.4603
TE-12 GDSC2 5.3562 17.255 -2.0304 22.7884
KYSE-50 GDSC2 5.3808 14.0161 -0.4215 16.5361
KYAE-1 GDSC2 5.954 7.3601 2.8732 0.1042
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC2 0.1867 11.0398 -3.3834 41.448
Cancer Drug Sensitivity Data Curated from 19 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NB69 GDSC2 -2.9052 0.9451 -3.0027 61.0172
TGW GDSC2 -1.2024 5.6238 -2.3913 46.9452
CHP-212 GDSC2 -1.1331 3.9372 -1.721 45.8093
IMR-5 GDSC2 -0.7714 6.7269 -2.3811 44.4594
NB(TU)1 GDSC2 0.1451 6.7837 -1.4561 37.9182
SK-N-AS GDSC2 0.4128 8.5926 -2.0069 38.0431
SJNB-13 GDSC2 1.3355 15.1652 -4.3269 38.8646
SJNB-10 GDSC2 2.1736 7.6648 0.1324 23.0753
CHP-134 GDSC2 2.6384 14.054 -2.6238 31.6042
SK-N-DZ GDSC2 2.8523 9.7145 -0.2737 22.7052
SJNB-14 GDSC2 2.8955 10.5839 -0.6703 24.3168
SiMa GDSC2 3.8553 11.8239 -0.4931 20.6889
Kelly GDSC2 3.882 14.3366 -1.7259 25.4084
SK-N-BE(2)-M17 GDSC2 3.8917 8.1033 1.3879 10.607
NH-12 GDSC2 4.0658 12.564 -0.6947 20.9878
KP-N-YN GDSC2 4.1246 10.4942 0.3808 15.7142
GOTO GDSC2 4.4297 13.3556 -0.8042 20.4898
SJNB-7 GDSC2 4.6631 12.5097 -0.2077 17.2584
GI-ME-N GDSC2 5.1991 16.4796 -1.7655 22.257
⏷ Show the Full List of 19 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC2 4.177 9.8828 0.724 13.7232
Cancer Drug Sensitivity Data Curated from 33 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
EW-3 GDSC2 -1.1011 8.5463 -3.5087 47.12
MG-63 GDSC2 -0.6986 8.8272 -3.2256 45.0074
SK-PN-DW GDSC2 -0.0695 8.9094 -2.6321 41.3929
NOS-1 [Human HNSCC] GDSC2 0.146 11.5796 -3.6808 41.9925
ES7 GDSC2 0.4881 9.0771 -2.1598 38.0647
CAL-72 GDSC2 1.018 10.8428 -2.4968 36.6987
HuO9 GDSC2 1.1851 9.2564 -1.5715 33.6754
ES8 GDSC2 1.3771 9.8788 -1.691 33.2834
EW-16 GDSC2 1.5491 12.52 -2.8269 35.5339
HOS GDSC2 1.6248 8.0129 -0.5538 28.3134
ES4 GDSC2 1.6579 9.3778 -1.1842 30.5946
NY GDSC2 2.3566 12.7568 -2.2223 31.4017
ES5 GDSC2 2.6462 12.4175 -1.8006 29.2425
TC-71 GDSC2 2.7512 15.7431 -3.3704 33.037
SaOS-2 GDSC2 2.8115 16.3932 -3.6437 33.4463
MHH-ES-1 GDSC2 3.037 13.4077 -1.9604 28.5513
EW-11 GDSC2 3.0576 11.4239 -0.9514 24.9556
EW-22 GDSC2 3.1062 10.5767 -0.4867 22.8626
A-673 GDSC2 3.251 13.2994 -1.726 27.1752
U2OS GDSC2 3.6797 19.0698 -4.2559 32.4516
G-292 clone A141B1 GDSC2 3.7486 17.8294 -3.5793 30.8748
EW-1 GDSC2 3.8278 14.3156 -1.7592 25.6666
CAL-78 GDSC2 4.0582 10.9495 0.1031 17.3166
CADO-ES1 GDSC2 4.1362 16.8739 -2.788 27.9602
EW-7 GDSC2 4.2399 7.4912 1.9439 6.38
CHSA8926 GDSC2 4.2904 10.6301 0.4403 14.9686
ES6 GDSC2 4.4637 8.3962 1.6618 7.5827
SK-ES-1 GDSC2 4.8514 12.9824 -0.3005 17.227
EW-18 GDSC2 4.9212 13.805 -0.6538 18.6286
EW-24 GDSC2 5.0962 22.215 -4.6898 30.1455
HuO-3N1 GDSC2 5.4939 13.5906 -0.1343 14.9694
EW-13 GDSC2 5.7095 19.3652 -2.8073 24.3846
H-EMC-SS GDSC2 5.8279 15.6734 -0.9105 17.6316
⏷ Show the Full List of 33 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 42 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MDA-MB-453 GDSC2 -3.3109 0.7565 -3.411 64.2286
HCC2157 GDSC2 -1.9785 1.5295 -2.0899 52.9188
Evsa-T GDSC2 -1.5088 2.9821 -1.8612 48.7218
Hs 578T GDSC2 -1.0651 7.4525 -2.9945 46.6179
MDA-MB-231 GDSC2 0.0182 15.4438 -5.6727 44.2848
HCC1569 GDSC2 0.0495 8.4412 -2.2981 40.2727
DU4475 GDSC2 1.304 7.3037 -0.5268 29.4951
CAL-85-1 GDSC2 1.4157 14.9796 -4.1629 38.3814
MDA-MB-468 GDSC2 1.805 12.0029 -2.3396 33.5217
MCF-7 GDSC2 1.9419 9.8826 -1.1692 29.4958
CAMA-1 GDSC2 2.1632 13.368 -2.6967 33.2385
CAL-51 GDSC2 2.8957 8.5394 0.35 19.4729
HDQ-P1 GDSC2 2.9136 15.1918 -2.9567 31.6349
CAL-120 GDSC2 3.4478 11.7974 -0.8113 23.2163
OCUB-M GDSC2 3.4947 6.8605 1.6944 9.7926
MDA-MB-415 GDSC2 3.5152 12.6423 -1.1782 24.4701
HCC1806 GDSC2 3.5503 9.7138 0.3143 17.6554
EFM-192A GDSC2 3.6278 11.4385 -0.4844 21.294
HCC1187 GDSC2 3.6449 13.6638 -1.5824 25.5672
BT-549 GDSC2 3.7005 18.4622 -3.9351 31.759
HCC38 GDSC2 3.7076 9.4403 0.5779 15.7936
MRK-nu-1 GDSC2 3.8811 11.4453 -0.2837 19.6667
HCC1428 GDSC2 3.9446 12.197 -0.6079 20.9454
JIMT-1 GDSC2 4.0502 9.4496 0.8418 13.393
T-47D GDSC2 4.0559 17.2712 -3.0509 28.8496
AU565 GDSC2 4.0776 8.0961 1.5316 9.2667
BT-474 GDSC2 4.0803 15.7371 -2.2655 26.6091
MDA-MB-157 GDSC2 4.1432 14.7515 -1.7237 24.708
MDA-MB-361 GDSC2 4.305 12.4723 -0.462 19.3364
EFM-19 GDSC2 4.3148 9.4716 1.0302 11.6465
HCC1954 GDSC2 4.3943 6.686 2.4274 3.2001
MDA-MB-330 GDSC2 4.523 20.8205 -4.4477 30.8921
ZR-75-30 GDSC2 4.6551 7.1892 2.3539 3.1666
COLO 824 GDSC2 4.6617 11.458 0.3093 14.7222
HCC70 GDSC2 4.7084 7.9904 2.0172 4.9853
HCC1419 GDSC2 4.8685 6.8155 2.6336 1.4308
BT-20 GDSC2 4.9134 7.5832 2.3259 2.9123
HCC1937 GDSC2 5.1209 8.9351 1.8352 5.2691
HCC1500 GDSC2 5.9392 22.3356 -4.1016 27.1935
HCC1143 GDSC2 6.3846 15.9787 -0.6719 15.4831
MDA-MB-436 GDSC2 6.4122 21.6208 -3.3973 24.5492
MFM-223 GDSC2 6.463 19.842 -2.4891 21.8866
⏷ Show the Full List of 42 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 34 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
D283 Med GDSC2 -2.0761 4.8647 -3.0524 52.7399
KS-1 [Human Krukenberg tumour] GDSC2 -1.3816 7.3239 -3.2689 48.4405
H4 GDSC2 -0.354 18.2824 -7.4061 46.2628
YH-13 GDSC2 0.1881 10.2379 -3.0006 40.8823
DK-MG GDSC2 0.4486 9.1388 -2.2275 38.3798
M059J GDSC2 0.4906 9.8492 -2.5226 38.8124
GI-1 GDSC2 0.5572 9.661 -2.3687 38.2275
8-MG-BA GDSC2 1.2383 10.7632 -2.2515 35.3085
A-172 GDSC2 2.1695 17.2813 -4.6399 36.952
42-MG-BA GDSC2 2.2915 11.4596 -1.6346 29.8605
GB-1 GDSC2 2.6459 10.0175 -0.6047 24.8503
ONS-76 GDSC2 2.6536 15.2613 -3.2135 32.9679
D-392MG GDSC2 2.8484 12.8638 -1.8491 28.7704
KALS-1 GDSC2 3.0413 12.768 -1.6369 27.499
SF539 GDSC2 3.2988 18.179 -4.1259 33.1331
Daoy GDSC2 3.4898 13.321 -1.5384 25.8516
CAS-1 GDSC2 3.4974 23.5304 -6.6365 36.531
PFSK-1 GDSC2 3.8234 8.6546 1.0612 12.7327
U-251MG GDSC2 3.8715 15.0802 -2.1057 26.666
AM-38 GDSC2 3.8872 12.352 -0.7311 21.6304
SW1088 GDSC2 3.9007 12.367 -0.7278 21.5791
SF268 GDSC2 3.9351 12.1093 -0.5718 20.8143
D-263MG GDSC2 3.986 10.7508 0.1454 17.2993
LN-405 GDSC2 4.0506 11.6043 -0.2288 18.9456
SK-MG-1 GDSC2 4.3589 10.4858 0.5632 14.1383
U-118MG GDSC2 4.3622 7.9253 1.8189 6.8648
LN-18 GDSC2 4.4081 9.7318 0.971 11.7564
T98G GDSC2 4.4629 15.5693 -1.8788 24.4122
U-87MG ATCC GDSC2 4.7912 9.4213 1.3928 8.4524
KINGS-1 GDSC2 4.8494 10.1352 1.089 10.0636
GaMG GDSC2 4.8929 16.1756 -1.8472 23.2555
Becker GDSC2 5.0959 17.1922 -2.196 23.9165
DBTRG-05MG GDSC2 6.8791 21.615 -3.0563 22.728
LN-229 GDSC2 7.7567 23.8141 -3.5049 22.3361
⏷ Show the Full List of 34 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TGBC24TKB GDSC2 0.8887 9.552 -1.997 36.0263
ETK-1 GDSC2 4.046 6.8378 2.1248 5.7128
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ESS-1 GDSC2 1.0898 8.8607 -1.473 33.7614
KLE GDSC2 1.6001 18.1048 -5.5493 39.6744
RL95-2 GDSC2 4.7364 19.8214 -3.7807 29.0025
MFE-280 GDSC2 5.3493 15.35 -1.0975 19.4462
MFE-296 GDSC2 5.3619 10.4093 1.2999 7.8208
MFE-319 GDSC2 5.6208 12.6608 0.4016 12.0857
EN GDSC2 6.5404 16.0694 -0.6102 14.9135
AN3-CA GDSC2 6.6778 15.6338 -0.3122 13.3574
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 129 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
L-1236 GDSC2 -5.881 0.6114 -6.1324 76.6652
BC-1 GDSC2 -5.5267 5.8115 -7.1134 66.7734
MV4-11 GDSC2 -5.3407 -3.7265 -5.3407 85.7741
A3/Kawakami GDSC2 -5.2062 -3.3954 -5.2062 84.2475
H9 GDSC2 -5.1265 -1.3651 -5.151 78.9732
MOLP-8 GDSC2 -4.8771 0.7226 -5.0735 72.9113
NCI-H929 GDSC2 -4.8268 2.8467 -5.4459 68.6665
Kasumi-1 GDSC2 -4.7884 -1.6012 -4.7992 77.8669
A4/Fukuda GDSC2 -4.7409 -0.5464 -4.796 75.17
OPM-2 GDSC2 -4.594 -1.8178 -4.5988 77.175
WSU-NHL GDSC2 -4.5897 -1.756 -4.5953 77.0249
BL-41 GDSC2 -4.5178 4.5685 -5.6041 65.0235
NALM-6 GDSC2 -4.4033 3.3235 -5.1093 66.2605
ST486 GDSC2 -4.378 0.0785 -4.4671 71.9579
SCC-3 GDSC2 -4.237 0.2319 -4.3336 70.8907
OCI-AML-3 GDSC2 -4.1925 -1.1608 -4.2043 73.3018
AMO1 GDSC2 -4.1078 3.159 -4.7424 65.2306
Ku812 GDSC2 -4.0445 -0.922 -4.0603 71.8778
SU-DHL-6 GDSC2 -3.8974 -0.7834 -3.9147 70.6193
SU-DHL-5 GDSC2 -3.8453 -1.5583 -3.8474 71.2472
KMS-12-BM GDSC2 -3.7543 4.4541 -4.737 62.0391
MOLM-13 GDSC2 -3.7443 -0.8168 -3.7575 69.5388
Namalwa GDSC2 -3.6792 9.0842 -6.4066 58.1231
OCI-AML-2 GDSC2 -3.649 -0.343 -3.678 68.1654
Karpas-45 GDSC2 -3.6442 -1.1972 -3.6485 69.1952
DoHH2 GDSC2 -3.5107 0.2339 -3.5714 66.3479
SR GDSC2 -3.4833 10.0437 -6.6115 56.9791
DG-75 GDSC2 -3.4273 4.3905 -4.361 60.5787
OCI-M1 GDSC2 -3.4032 -2.0621 -3.4033 67.4576
KY821 GDSC2 -3.1698 0.6566 -3.2516 63.3306
RPMI-8866 GDSC2 -3.1636 2.9132 -3.6486 60.6808
ML-2 GDSC2 -3.1501 2.6123 -3.5608 60.9236
697 GDSC2 -3.0922 2.9579 -3.5821 60.2122
BV-173 GDSC2 -3.0837 6.2672 -4.6473 57.4698
SKM-1 GDSC2 -2.8704 6.8381 -4.6398 56.1732
HAL-01 GDSC2 -2.83 6.8668 -4.6081 55.9743
BALL-1 GDSC2 -2.8013 2.8694 -3.2426 58.4854
Jiyoye GDSC2 -2.7703 4.9664 -3.8387 56.7478
Raji GDSC2 -2.7124 15.682 -8.4002 53.0477
Daudi GDSC2 -2.7067 3.2927 -3.2494 57.5385
SU-DHL-10 GDSC2 -2.6814 1.1632 -2.7911 59.0674
Loucy GDSC2 -2.3796 4.8525 -3.3766 54.6018
EoL-1 GDSC2 -2.3729 1.5289 -2.5112 56.315
P30/OHK GDSC2 -2.3673 2.1712 -2.6148 55.9079
LC4-1 GDSC2 -2.3415 0.5001 -2.3735 56.5365
JJN-3 GDSC2 -2.3139 2.6323 -2.6549 55.2505
KOPN-8 GDSC2 -2.2824 2.2917 -2.5469 55.1837
MHH-CALL-2 GDSC2 -2.143 2.4111 -2.4203 54.0328
HEL GDSC2 -2.0474 0.8934 -2.095 53.6959
P32/ISH GDSC2 -2.0363 6.1158 -3.4704 52.208
JVM-3 GDSC2 -2.0001 13.5014 -6.6776 51.1551
JSC-1 GDSC2 -1.9748 5.7586 -3.2682 51.9206
U-698-M GDSC2 -1.9487 5.6066 -3.1831 51.7914
CTV-1 GDSC2 -1.9416 2.0404 -2.13 52.4797
MM1.S GDSC2 -1.821 4.7289 -2.7294 51.1
NOMO-1 GDSC2 -1.6175 5.4701 -2.777 49.7198
MN-60 GDSC2 -1.5074 7.846 -3.6215 49.1905
DEL GDSC2 -1.4363 16.6224 -7.6159 49.3379
Jurkat GDSC2 -1.3797 4.9206 -2.32 48.0256
ARH-77 GDSC2 -1.2407 6.4439 -2.7567 47.4228
Karpas-422 GDSC2 -1.2039 12.8036 -5.5696 48.2958
EM-2 GDSC2 -1.175 3.7827 -1.7189 46.0974
GA-10 GDSC2 -1.1592 6.8014 -2.8178 47.0021
Karpas-1106P GDSC2 -1.1482 9.4679 -3.9691 47.5628
SUP-B15 GDSC2 -1.1228 4.5655 -1.9174 45.9844
MOLT-16 GDSC2 -1.1122 5.2674 -2.1594 46.1802
GDM-1 GDSC2 -1.0993 5.2022 -2.1212 46.0594
CA46 GDSC2 -1.0702 12.2529 -5.1793 47.6958
RPMI-8226 GDSC2 -1.0638 6.2792 -2.5033 46.2185
MEG-01 GDSC2 -1.0437 8.3082 -3.3447 46.7447
HL-60 GDSC2 -1.0121 3.4973 -1.4569 44.5609
RC-K8 GDSC2 -0.938 3.6038 -1.407 43.9625
SUP-T1 GDSC2 -0.8245 6.8542 -2.4901 44.8768
P12-Ichikawa GDSC2 -0.7318 5.8254 -1.9699 43.6614
Karpas-620 GDSC2 -0.7296 13.488 -5.4352 46.5761
JURL-MK1 GDSC2 -0.6608 2.971 -0.934 40.9554
IM-9 GDSC2 -0.5894 4.8943 -1.4597 41.8741
KE-37 GDSC2 -0.5869 5.4031 -1.6498 42.2586
MLMA GDSC2 -0.5423 6.5194 -2.0549 42.7492
L-363 GDSC2 -0.2356 10.4266 -3.5032 43.2798
PF-382 GDSC2 -0.166 8.1272 -2.3714 41.3997
SUP-M2 GDSC2 -0.1452 5.9596 -1.4059 39.263
BE-13 GDSC2 -0.0527 15.8997 -5.9612 44.6903
KMOE-2 GDSC2 -0.006 5.5705 -1.1002 37.6751
MHH-PREB-1 GDSC2 0.1378 9.7995 -2.8425 40.839
ALL-PO GDSC2 0.174 13.2303 -4.45 42.7523
RS4;11 GDSC2 0.203 9.3933 -2.5878 40.1317
JVM-2 GDSC2 0.2053 10.4702 -3.0941 40.9566
MOLT-13 GDSC2 0.417 11.2844 -3.2799 40.4152
LP-1 GDSC2 0.4918 7.4391 -1.3967 36.1107
DND-41 GDSC2 0.5929 7.0737 -1.1291 34.8278
SUP-HD1 GDSC2 0.6669 6.0797 -0.6122 32.6455
LAMA-84 GDSC2 0.7355 9.1254 -1.9415 36.5124
VAL GDSC2 0.7791 10.8596 -2.7306 38.0866
RPMI-6666 GDSC2 0.8092 7.9241 -1.304 34.4182
L-540 GDSC2 0.8595 24.2588 -9.2633 44.2152
ALL-SIL GDSC2 1.072 10.6063 -2.3312 36.1209
TK [Human B-cell lymphoma] GDSC2 1.0902 9.7428 -1.8962 34.966
KCL-22 GDSC2 1.1064 7.5058 -0.8157 31.466
VL51 GDSC2 1.2865 14.3934 -3.9898 38.5171
GR-ST GDSC2 1.4087 11.3631 -2.3865 35.0157
Ramos.2G6.4C10 GDSC2 1.6086 10.5378 -1.7974 32.7337
K-562 GDSC2 1.6266 17.2451 -5.0985 39.0625
CCRF-CEM GDSC2 1.8068 11.2145 -1.9486 32.4626
KG-1 GDSC2 2.0284 9.1107 -0.7103 27.4337
OCI-AML-5 GDSC2 2.0834 6.843 0.4464 21.7753
HH [Human lymphoma] GDSC2 2.0897 16.8335 -4.4864 36.9327
ME1 GDSC2 2.1224 27.7767 -9.9189 42.0866
DB GDSC2 2.3224 11.2898 -1.5228 29.3926
Reh GDSC2 2.3274 11.455 -1.6004 29.6307
CESS GDSC2 2.4833 10.2069 -0.8422 26.3725
EJM GDSC2 2.5514 11.0745 -1.2138 27.5618
L-428 GDSC2 2.6703 10.3508 -0.7493 25.3744
CML-T1 GDSC2 2.7022 10.3012 -0.6967 25.052
SU-DHL-8 GDSC2 2.8276 3.7111 2.6424 5.9955
SK-MM-2 GDSC2 3.339 8.2089 0.8926 15.0866
KM-H2 GDSC2 3.3495 16.3492 -3.1688 30.952
EB2 GDSC2 3.3666 12.4015 -1.1807 24.9112
TUR GDSC2 3.6622 11.8974 -0.6856 22.0698
WIL2 NS GDSC2 4.0992 11.6478 -0.2123 18.7368
Granta-519 GDSC2 4.2651 10.2738 0.5973 14.192
Farage GDSC2 4.4358 13.1717 -0.7082 20.0703
MOLT-4 GDSC2 4.5468 11.0708 0.4149 14.4568
HC-1 GDSC2 4.6576 9.2419 1.3876 8.7727
ATN-1 GDSC2 4.694 20.9877 -4.3951 30.413
U266B1 GDSC2 4.7607 16.0015 -1.8624 23.6244
HDLM-2 GDSC2 4.7781 11.0718 0.5833 13.0083
Hs 445 GDSC2 4.7892 6.9754 2.5245 2.0575
Karpas-231 GDSC2 5.0119 6.3144 2.8942 0.3342
⏷ Show the Full List of 129 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 19 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CAL-54 GDSC2 -1.1721 16.2833 -7.201 48.5116
769-P GDSC2 -1.0032 8.0362 -3.1837 46.4363
TK-10 GDSC2 -0.0468 6.9125 -1.7096 39.4988
A-498 GDSC2 1.9151 15.1489 -3.8013 36.2906
ACHN GDSC2 2.282 13.5347 -2.6751 32.8156
LB996-RCC GDSC2 2.9617 14.2855 -2.4629 30.2299
NCC010 GDSC2 3.1486 15.1984 -2.7614 30.49
BFTC-909 GDSC2 3.1924 12.4326 -1.3418 26.0211
KMRC-20 GDSC2 3.4809 9.4568 0.3859 17.4803
RCC10RGB GDSC2 3.9817 9.7693 0.6302 14.7544
SN12C GDSC2 4.4879 10.4756 0.6642 13.2697
A-704 GDSC2 4.5414 11.151 0.3713 14.6974
HA7-RCC GDSC2 4.5496 14.7157 -1.3869 22.4718
VMRC-RCZ GDSC2 4.7015 10.7426 0.689 12.6199
RXF 393L GDSC2 4.7651 14.3151 -1.0231 20.5385
SW13 GDSC2 4.7778 9.7404 1.2301 9.4187
KTCTL-195 GDSC2 5.079 21.9788 -4.5857 29.9757
OS-RC-2 GDSC2 5.5035 7.4061 2.6876 0.6728
786-O GDSC2 7.2429 29.3988 -6.6105 29.5994
⏷ Show the Full List of 19 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 46 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCT 15 GDSC2 -1.7401 3.7981 -2.3394 50.6034
HT-29 GDSC2 -1.0741 7.6682 -3.0966 46.7355
CCK-81 GDSC2 -1.0435 7.5474 -3.0129 46.5189
HCT 116 GDSC2 -0.2819 6.8941 -1.9439 41.185
LS411N GDSC2 -0.2491 8.3411 -2.5521 42.0841
HCC2998 GDSC2 0.3468 8.9355 -2.232 38.825
SW626 GDSC2 0.5699 11.8723 -3.4185 40.0589
RKO GDSC2 0.5858 15.2687 -5.061 42.0303
CL-11 GDSC2 0.8041 8.8812 -1.759 35.7553
LoVo GDSC2 0.833 16.8614 -5.6195 41.8425
SNU-175 GDSC2 0.8778 7.7459 -1.1532 33.6368
COLO205 GDSC2 1.0697 7.3012 -0.7565 31.3985
DiFi GDSC2 1.1862 12.3545 -3.0779 37.2845
SW1417 GDSC2 1.2566 11.7416 -2.7125 36.2976
SW948 GDSC2 1.3617 6.0538 0.1081 26.3721
SNU-C2B GDSC2 1.6375 12.0221 -2.5009 34.4906
SW48 GDSC2 1.824 16.6022 -4.6044 37.8467
NCI-H747 GDSC2 1.98 11.8034 -2.0832 32.2467
SNU-407 GDSC2 1.995 10.759 -1.553 30.6079
SW1463 GDSC2 2.3163 8.7133 -0.2517 24.4142
NCI-H716 GDSC2 2.4083 11.8986 -1.7497 29.8416
C2BBe1 GDSC2 2.5015 10.3688 -0.9066 26.5664
LS180 GDSC2 2.7131 14.4749 -2.7697 31.7518
GP5d GDSC2 2.7317 9.5758 -0.3095 23.2635
SNU-C1 GDSC2 3.1179 10.2791 -0.3281 22.1131
RCM-1 [Human ESC] GDSC2 3.1202 11.6831 -1.0279 25.0631
LS513 GDSC2 3.1646 11.3184 -0.8081 24.0504
CW-2 GDSC2 3.5235 13.1939 -1.4471 25.434
SNU-C5 GDSC2 3.5497 12.2829 -0.9702 23.5631
SNU-61 GDSC2 3.5786 11.13 -0.3703 20.9234
SNU-81 GDSC2 3.7664 9.9288 0.3812 16.6868
HT-55 GDSC2 3.8595 19.408 -4.2777 32.067
T84 GDSC2 3.9363 10.4271 0.2674 16.8116
HT115 GDSC2 4.2515 10.8762 0.2887 15.8614
MDST8 GDSC2 4.3418 7.0805 2.2095 4.5699
SW1116 GDSC2 4.4009 13.6811 -0.9883 21.3164
SNU-1040 GDSC2 4.4431 12.8393 -0.5377 19.314
SK-CO-1 GDSC2 4.5703 15.4368 -1.7292 23.6392
SW837 GDSC2 4.5968 11.8144 0.0857 16.0098
SW620 GDSC2 4.6774 17.0464 -2.446 25.6672
CaR-1 GDSC2 4.7201 12.6873 -0.2527 17.3273
COLO 320HSR GDSC2 4.7822 11.3713 0.4398 13.7563
LS1034 GDSC2 4.9277 9.2449 1.568 7.1577
KM12 GDSC2 5.7633 7.5618 2.7341 0.4059
LS123 GDSC2 5.9269 19.4909 -2.7076 23.6381
COLO 678 GDSC2 6.8742 23.0742 -3.7729 24.6141
⏷ Show the Full List of 46 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC2 3.9233 11.6084 -0.3314 19.7701
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HLE GDSC2 0.4382 11.5106 -3.3685 40.4693
SNU-387 GDSC2 1.3476 9.9664 -1.7613 33.5996
SNU-398 GDSC2 1.5985 11.035 -2.0507 33.4811
HuH-1 GDSC2 3.1162 14.6403 -2.5096 29.9148
JHH-2 GDSC2 3.2723 7.9476 0.9676 14.8497
JHH-6 GDSC2 3.3224 17.744 -3.8887 32.6045
Hep 3B2.1-7 GDSC2 3.5447 13.0335 -1.3494 25.0218
Hep-G2/C3A GDSC2 3.6258 6.6714 1.8932 8.1917
JHH-7 GDSC2 3.8078 29.8591 -9.5439 38.8254
JHH-1 GDSC2 3.8178 18.1419 -3.679 30.9253
SNU-423 GDSC2 4.3215 28.5017 -8.445 36.9423
JHH-4 GDSC2 5.554 17.3731 -1.9414 22.0504
SK-HEP-1 GDSC2 5.5963 17.9285 -2.1834 22.7488
Huh-7 GDSC2 6.1234 16.6809 -1.1913 18.1164
SNU-449 GDSC2 6.6357 15.3966 -0.2275 13.0606
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 129 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H526 GDSC2 -4.4573 -0.6377 -4.4964 73.8965
RERF-LC-KJ GDSC2 -3.2059 -0.2544 -3.2265 64.6064
EMC-BAC-2 GDSC2 -2.489 7.9641 -4.694 53.9869
NCI-H2122 GDSC2 -1.8675 5.2779 -2.9745 51.3381
IST-SL2 GDSC2 -1.604 5.9097 -2.9299 49.6469
NCI-H211 GDSC2 -1.2989 4.8846 -2.22 47.4284
Lu-139 GDSC2 -1.2584 5.8306 -2.5311 47.386
NCI-H446 GDSC2 -1.2031 4.8347 -2.0988 46.7003
Ms-1 GDSC2 -0.9361 4.7958 -1.797 44.6208
DMS 273 GDSC2 -0.9236 14.9154 -6.3056 47.5431
SBC-3 GDSC2 -0.6442 8.7315 -3.1274 44.6588
EPLC-272H GDSC2 -0.5546 5.8403 -1.7883 42.3432
A-549 GDSC2 -0.5087 7.2686 -2.3401 43.0246
HCC44 GDSC2 -0.3749 9.5011 -3.2092 43.5342
NCI-H1155 GDSC2 -0.3276 7.2082 -2.1274 41.7591
COR-L105 GDSC2 -0.1894 12.4196 -4.405 43.9925
NCI-H1299 GDSC2 -0.041 10.1677 -3.1908 42.0955
NCI-H810 GDSC2 -0.0177 8.6184 -2.4465 40.8476
NCI-H2804 GDSC2 0.1607 11.6166 -3.6845 41.9419
LXF 289 GDSC2 0.2612 8.3087 -2.0257 38.7576
Calu-3 GDSC2 0.5144 10.116 -2.6267 38.9182
HARA [Human squamous cell lung carcinoma] GDSC2 0.6173 12.9278 -3.8867 40.564
NCI-H2795 GDSC2 0.6528 20.4532 -7.5584 43.7724
NCI-H2135 GDSC2 0.8155 11.4497 -2.9819 38.4269
LCLC-97TM1 GDSC2 0.8876 8.2942 -1.4004 34.379
NCI-H1975 GDSC2 1.0216 5.4744 0.0156 28.2937
NCI-H1792 GDSC2 1.0253 9.2011 -1.6979 34.6808
NCI-H524 GDSC2 1.2863 8.6465 -1.1818 32.0305
NCI-H3122 GDSC2 1.5047 7.9471 -0.6371 29.1302
SW1271 GDSC2 1.5682 9.1288 -1.147 30.8053
EBC-1 GDSC2 1.6917 16.9213 -4.8799 38.5993
NCI-H522 GDSC2 1.7273 10.3928 -1.6169 31.7609
NCI-H1944 GDSC2 1.7551 12.4501 -2.6057 34.3424
NCI-H1915 GDSC2 1.7811 12.8105 -2.7606 34.6152
COR-L311 GDSC2 1.783 5.4884 0.789 21.0413
SBC-5 GDSC2 1.8529 7.8591 -0.263 26.1642
Lu-65 GDSC2 1.8703 14.5334 -3.5352 35.9374
NCI-H1876 GDSC2 2.006 13.1689 -2.737 33.8326
NCI-H596 GDSC2 2.174 10.0933 -1.0623 28.2822
CPC-N GDSC2 2.2196 10.3766 -1.1615 28.4884
HCC78 GDSC2 2.4477 19.9689 -5.7408 37.7685
NCI-H82 GDSC2 2.5037 13.8837 -2.6554 32.0882
DMS 114 GDSC2 2.5152 9.356 -0.3912 24.3581
NCI-H2461 GDSC2 2.6051 16.2479 -3.7477 34.2196
NCI-H2810 GDSC2 2.6381 17.4194 -4.3044 35.1574
SK-LU-1 GDSC2 2.6555 16.0412 -3.6012 33.7876
HOP-62 GDSC2 2.7666 9.948 -0.4646 23.8459
LCLC-103H GDSC2 2.8196 18.2612 -4.5703 35.1415
NCI-H2731 GDSC2 2.8533 8.5966 0.2846 19.9538
NCI-H1693 GDSC2 2.8631 10.2345 -0.5238 23.7934
NCI-H23 GDSC2 2.8989 10.4288 -0.59 23.9647
NCI-H226 GDSC2 2.9197 13.1651 -1.9388 28.8339
NCI-H1755 GDSC2 2.9446 16.0194 -3.3439 32.4447
NCI-H322M GDSC2 2.9788 11.0604 -0.8368 24.742
NCI-H841 GDSC2 3.0404 11.8215 -1.1647 25.8296
SHP-77 GDSC2 3.0406 9.6222 -0.0656 21.1174
NCI-H1993 GDSC2 3.2385 14.352 -2.2628 28.8739
UMC-11 GDSC2 3.2935 8.1154 0.9015 15.1713
NCI-H520 GDSC2 3.3311 16.073 -3.046 30.7049
NCI-H2023 GDSC2 3.4114 11.9717 -0.9286 23.7994
NCI-H720 GDSC2 3.4153 10.7283 -0.3038 21.0977
EKVX GDSC2 3.4724 14.7348 -2.2597 28.211
NCI-H358 GDSC2 3.5675 14.1264 -1.877 26.7677
LOU-NH91 GDSC2 3.6935 14.3735 -1.8974 26.4864
NCI-H1623 GDSC2 3.7101 8.9308 0.834 14.3557
NCI-H1666 GDSC2 3.7398 21.9512 -5.6468 34.678
NCI-H1963 GDSC2 3.764 7.8148 1.4324 10.6729
A-427 GDSC2 3.8264 16.4333 -2.8182 28.8259
Lu-135 GDSC2 3.831 13.3923 -1.2956 24.0222
NCI-H2029 GDSC2 3.9663 6.7795 2.0963 6.0721
DMS 53 GDSC2 3.9691 10.4329 0.2904 16.6034
PC-14 GDSC2 4.0274 10.5866 0.2595 16.6052
Lu-99A GDSC2 4.057 7.1199 1.9952 6.4823
NCI-H2085 GDSC2 4.0764 11.281 -0.0477 18.0112
LC-1/sq GDSC2 4.1191 17.17 -2.9495 28.4316
NCI-H650 GDSC2 4.1316 12.3894 -0.556 20.2115
NCI-H1694 GDSC2 4.1387 10.2192 0.5281 14.8938
NCI-H209 GDSC2 4.1672 20.9416 -4.7937 32.3336
DMS 79 GDSC2 4.2403 18.1504 -3.3416 29.1212
NCI-H1563 GDSC2 4.3008 10.7274 0.4 15.1544
NCI-H2818 GDSC2 4.3151 13.2152 -0.8234 20.8665
NCI-H196 GDSC2 4.3498 13.9182 -1.1458 22.0692
NCI-H2405 GDSC2 4.4522 10.6251 0.5641 13.8994
NCI-H2227 GDSC2 4.4752 15.8068 -1.9874 24.7382
HCC827 GDSC2 4.5283 11.3383 0.2693 15.2564
NCI-H2373 GDSC2 4.5342 18.3205 -3.1926 28.0548
KNS-62 GDSC2 4.5501 15.3567 -1.7051 23.6064
NCI-H1048 GDSC2 4.5598 12.734 -0.3965 18.3864
HCC366 GDSC2 4.5956 12.568 -0.2873 17.7972
NCI-H1092 GDSC2 4.6141 6.7475 2.5285 2.2843
COR-L23 GDSC2 4.6437 13.1182 -0.523 18.7406
SW1573 GDSC2 4.6564 11.3851 0.3412 14.5708
NCI-H2087 GDSC2 4.6923 12.7796 -0.3191 17.7024
NCI-H1651 GDSC2 4.7172 19.5064 -3.639 28.7188
NCI-H1781 GDSC2 4.73 6.4769 2.7059 1.2537
NCI-H345 GDSC2 4.7659 5.8364 2.9718 0.2461
NCI-H513 GDSC2 4.8233 11.9598 0.1813 14.981
NCI-H2869 GDSC2 4.859 15.3462 -1.4622 21.9854
NCI-H3255 GDSC2 4.8783 12.7376 -0.1602 16.5094
NCI-H250 GDSC2 4.8806 12.0026 0.2021 14.7403
NCI-H2803 GDSC2 4.9203 18.6576 -3.058 26.8134
HOP-92 GDSC2 4.9701 17.4155 -2.4028 24.847
NCI-H2722 GDSC2 4.9748 19.3441 -3.3568 27.4582
Calu-6 GDSC2 4.9856 10.26 1.1224 9.5788
RERF-LC-Sq1 GDSC2 4.991 11.7846 0.3881 13.5363
Lu-165 GDSC2 5.0652 16.1657 -1.7113 22.3813
NCI-H2141 GDSC2 5.1027 7.0611 2.6457 1.1374
VMRC-LCD GDSC2 5.1163 20.0029 -3.5744 27.6789
HCC15 GDSC2 5.1857 13.1647 -0.1459 15.7185
NCI-H661 GDSC2 5.2089 9.0722 1.8257 5.1684
NCI-H2170 GDSC2 5.2309 11.1606 0.8567 10.5228
COLO 668 GDSC2 5.4293 7.7962 2.5017 1.4293
NCI-H2228 GDSC2 5.4706 8.9069 2.0515 3.5346
SK-MES-1 GDSC2 5.5033 17.0427 -1.8163 21.7395
ABC-1 GDSC2 5.5124 14.1118 -0.3745 16.0302
NCI-H2595 GDSC2 5.5267 19.5725 -3.047 25.4413
NCI-H2591 GDSC2 5.8302 18.5621 -2.3222 22.6803
NCI-H1568 GDSC2 5.9576 19.68 -2.7779 23.7772
NCI-H1869 GDSC2 5.9709 18.649 -2.2617 22.1908
NCI-H1650 GDSC2 5.989 13.505 0.2448 12.1119
IA-LM GDSC2 6.0362 17.5453 -1.6742 20.0852
NCI-H441 GDSC2 6.1803 15.3429 -0.5055 15.1857
NCI-H1435 GDSC2 6.2719 17.9536 -1.705 19.7017
NCI-H1355 GDSC2 6.4137 23.1843 -4.1651 26.4124
NCI-H2369 GDSC2 6.5161 16.1397 -0.6601 15.1718
NCI-H1581 GDSC2 6.8098 26.6802 -5.5932 28.5955
NCI-H1793 GDSC2 6.8844 18.3209 -1.4565 17.5846
NCI-H727 GDSC2 7.0392 21.6145 -2.942 22.1031
LK-2 GDSC2 7.3377 25.3894 -4.5704 25.6241
⏷ Show the Full List of 129 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC2 -0.2457 10.4887 -3.5423 43.3646
Cancer Drug Sensitivity Data Curated from 19 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYSE-140 GDSC2 -0.5265 10.3753 -3.7652 44.7402
OE33 GDSC2 1.6214 9.2222 -1.1426 30.5867
KYSE-270 GDSC2 2.3553 12.6406 -2.1656 31.2478
TE-15 GDSC2 2.886 11.2745 -1.0232 25.7713
TE-6 GDSC2 3.2499 9.4007 0.2223 19.0272
OE19 GDSC2 3.3869 16.2827 -3.1044 30.6981
OE21 GDSC2 3.5413 5.2289 2.5445 4.3201
TE-8 GDSC2 3.555 13.6184 -1.6334 25.994
TE-5 GDSC2 3.7487 13.0783 -1.2053 23.9117
EC-GI-10 GDSC2 3.9122 11.3941 -0.2334 19.3458
KYSE-520 GDSC2 4.1324 28.4922 -8.5944 37.4238
KYSE-450 GDSC2 4.3913 20.2139 -4.2503 30.7885
KYSE-410 GDSC2 4.6345 14.7479 -1.3374 22.0755
TE-1 GDSC2 4.8272 12.4411 -0.0521 16.1174
TE-4 GDSC2 4.9866 11.8281 0.3637 13.6718
KYSE-180 GDSC2 5.1634 11.6224 0.5881 12.1046
TE-9 GDSC2 5.7396 14.3773 -0.3436 15.3949
KYSE-70 GDSC2 5.8445 14.6018 -0.3793 15.3303
COLO 680N GDSC2 6.4473 21.7154 -3.418 24.534
⏷ Show the Full List of 19 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A2780 GDSC2 -1.7644 7.4746 -3.7318 50.5538
TOV-21G GDSC2 0.1898 6.9493 -1.4832 37.7729
OVCAR-5 GDSC2 0.75 14.6914 -4.6266 41.0544
OVTOKO GDSC2 1.3526 16.373 -4.9096 39.5917
TYK-nu GDSC2 1.5818 9.1154 -1.1278 30.6857
SK-OV-3 GDSC2 1.9607 13.5781 -2.9805 34.5285
Kuramochi GDSC2 2.1841 17.24 -4.6067 36.862
IGROV-1 GDSC2 2.2026 11.749 -1.8573 30.8483
OVCAR-8 GDSC2 2.5689 13.6316 -2.4731 31.4215
TOV-112D GDSC2 2.6475 10.2956 -0.7417 25.4182
OAW28 GDSC2 2.7738 7.2994 0.8597 17.0471
OVISE GDSC2 2.8663 12.1789 -1.4918 27.541
DOV13 GDSC2 2.9467 15.2632 -2.9642 31.5598
EFO-21 GDSC2 2.9831 19.7544 -5.1784 35.7044
ES-2 GDSC2 3.5928 10.2824 0.0648 18.8072
OV56 GDSC2 4.0081 7.8407 1.6058 8.9872
OVK18 GDSC2 4.2378 7.227 2.0699 5.6225
OVCAR-3 GDSC2 4.6508 15.3679 -1.6326 23.1041
OV-90 GDSC2 4.8359 11.0676 0.6268 12.6408
OAW42 GDSC2 4.8407 13.6662 -0.6455 18.7881
OVCAR-4 GDSC2 5.1304 15.3341 -1.2517 20.5521
EFO-27 GDSC2 5.4942 17.2194 -1.91 22.0784
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MIA PaCa-2 GDSC2 -2.4116 4.6005 -3.3258 54.9088
Panc 08.13 GDSC2 -0.299 6.4784 -1.7838 40.9501
PaTu 8988t GDSC2 0.1189 9.5719 -2.7542 40.7745
Panc 02.03 GDSC2 0.5076 9.7955 -2.4806 38.6596
KP-1N GDSC2 1.9633 9.834 -1.1257 29.2619
CFPAC-1 GDSC2 1.9787 12.9993 -2.6772 33.7788
KP-4 GDSC2 2.1727 11.6016 -1.8107 30.8067
Panc 10.05 GDSC2 2.5862 12.6211 -1.9541 29.9031
Capan-2 GDSC2 2.9433 12.1642 -1.4186 27.049
BxPC-3 GDSC2 3.2358 13.6877 -1.9329 27.8851
PL4 GDSC2 3.4061 16.0884 -2.9913 30.3702
Capan-1 GDSC2 3.8225 13.759 -1.4855 24.7362
HuP-T3 GDSC2 3.983 10.1751 0.4295 15.8352
DAN-G GDSC2 4.0308 11.8528 -0.3682 19.6441
SUIT-2 GDSC2 4.1123 15.3301 -2.0369 25.8186
HPAC GDSC2 4.2709 23.0661 -5.771 33.7351
PSN1 GDSC2 4.3327 8.7506 1.3969 9.4595
AsPC-1 GDSC2 4.8507 10.6911 0.8206 11.5553
KP-3 GDSC2 4.952 11.3054 0.5936 12.5501
SU.86.86 GDSC2 5.1147 6.676 2.8014 0.5502
KP-2 GDSC2 5.1265 10.668 1.0222 9.838
YAPC GDSC2 6.0249 16.7386 -1.289 18.698
HuP-T4 GDSC2 6.3064 20.7148 -3.03 23.7748
QGP-1 GDSC2 6.5399 27.9038 -6.4011 30.4416
PaTu 8902 GDSC2 6.9407 19.2319 -1.8565 18.8957
HPAF-II GDSC2 7.6341 29.1407 -6.1938 28.2738
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IST-Mes1 GDSC2 -1.3037 17.5225 -7.9246 48.9873
NCI-H28 GDSC2 1.9445 15.5621 -3.9808 36.5174
MPP 89 GDSC2 3.7157 15.6097 -2.497 28.2372
MSTO-211H GDSC2 4.26 12.2888 -0.4057 19.2012
NCI-H2052 GDSC2 6.8302 16.8999 -0.8129 15.1951
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LNCaP clone FGC GDSC2 -1.3066 8.0853 -3.5172 48.137
VCaP GDSC2 -1.2769 7.3584 -3.1744 47.8421
22Rv1 GDSC2 1.3857 20.4298 -6.8947 41.5277
DU145 GDSC2 3.8557 7.0225 1.8955 7.5836
PC-3 GDSC2 4.4889 13.9869 -1.072 21.4237
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC2 5.2865 10.4962 1.2102 8.466
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LOX-IMVI GDSC2 -3.1655 4.8312 -4.2209 58.8953
G-361 GDSC2 -0.9962 7.9791 -3.1515 46.3787
COLO 792 GDSC2 0.1341 21.0951 -8.3435 45.4137
SH-4 GDSC2 0.2486 9.6332 -2.6558 40.0604
A101D GDSC2 0.4696 15.6335 -5.3471 42.6533
M14 GDSC2 0.4936 13.1203 -4.0961 41.2599
IGR-37 GDSC2 0.6773 12.5208 -3.6322 39.9954
G-mel GDSC2 1.0546 9.8544 -1.9838 35.3352
RPMI-7951 GDSC2 1.4819 9.1742 -1.2503 31.4929
GAK GDSC2 1.7415 6.6962 0.1872 24.4338
CHL-1 GDSC2 1.8063 20.1998 -6.411 40.0713
SK-MEL-24 GDSC2 1.8541 13.7012 -3.1366 35.198
A-375 GDSC2 2.9508 14.7176 -2.6881 30.8586
UACC-62 GDSC2 3.0198 14.3093 -2.4255 29.9599
WM793 GDSC2 3.0634 20.7088 -5.5879 36.1114
HMV-II GDSC2 3.2501 11.6137 -0.8839 24.0996
COLO 679 GDSC2 3.4308 12.53 -1.1917 24.765
HT-144 GDSC2 3.6095 7.8586 1.2886 11.9655
A2058 GDSC2 3.7354 13.013 -1.1835 23.8656
CP66-MEL GDSC2 3.751 12.1807 -0.7552 22.1114
SK-MEL-5 GDSC2 3.9611 14.2788 -1.6334 24.8798
WM1552C GDSC2 3.9996 12.7662 -0.848 21.8087
WM278 GDSC2 4.2992 11.9021 -0.1834 18.0709
SK-MEL-2 GDSC2 4.4229 5.611 2.9129 0.6659
IGR-1 GDSC2 4.6712 11.3046 0.3916 14.2737
Mel JuSo GDSC2 5.4244 14.5268 -0.6396 17.3919
WM115 GDSC2 5.6718 15.1874 -0.7847 17.454
UACC-257 GDSC2 6.0473 19.7709 -2.7565 23.5291
COLO 829 GDSC2 6.8539 19.0065 -1.8077 18.8955
WT2-iPS GDSC2 7.2817 19.7923 -1.8926 18.3741
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC2 1.8273 9.2007 -0.9402 29.0741
Cancer Drug Sensitivity Data Curated from 18 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYM-1 GDSC2 -2.2144 5.2448 -3.3361 53.4713
SW982 GDSC2 -1.1253 8.8331 -3.6608 47.3149
Rh41 GDSC2 -1.012 4.3385 -1.7199 44.9934
G-401 GDSC2 -0.4239 5.9914 -1.7119 41.4695
G-402 GDSC2 0.2223 9.0412 -2.4041 39.7089
SK-LMS-1 GDSC2 0.5973 11.5288 -3.2263 39.6556
RD GDSC2 1.381 10.5287 -2.0039 34.1461
SK-UT-1 GDSC2 3.1932 16.7141 -3.4818 32.0806
VA-ES-BJ GDSC2 3.2028 13.4813 -1.8574 27.7417
GCT GDSC2 3.8613 15.3497 -2.2485 27.1286
EW-8 GDSC2 3.975 8.6794 1.1661 11.7144
SW872 GDSC2 4.3133 13.1954 -0.8149 20.8361
MES-SA GDSC2 4.3366 16.9447 -2.6634 27.121
SW684 GDSC2 4.4749 17.4677 -2.8146 27.2026
Rh30 GDSC2 4.5564 9.042 1.4139 8.8441
RKN GDSC2 4.8377 11.3888 0.4714 13.4601
A-204 GDSC2 4.9079 13.4408 -0.4843 17.9204
HT-1080 GDSC2 6.1159 13.7165 0.228 11.9419
⏷ Show the Full List of 18 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TGBC11TKB GDSC2 -1.3216 9.0637 -3.9634 48.3569
Hs 746.T GDSC2 -0.6362 7.9936 -2.7891 44.2553
AGS GDSC2 -0.3005 7.6799 -2.3075 41.9355
MKN1 GDSC2 0.0515 11.5007 -3.7338 42.4139
NCI-N87 GDSC2 0.5427 8.9583 -2.0504 37.5842
MKN45 GDSC2 0.984 13.0187 -3.5902 38.8746
ECC10 GDSC2 0.9938 9.5924 -1.9157 35.3978
23132/87 GDSC2 1.2592 12.3715 -3.019 36.9184
IM95 GDSC2 1.5236 15.7827 -4.464 38.5021
OCUM-1 GDSC2 1.9535 12.2101 -2.3085 32.943
RERF-GC-1B GDSC2 2.0737 9.2622 -0.7433 27.4032
GCIY GDSC2 2.3375 11.684 -1.7054 29.934
MKN28 GDSC2 2.4413 15.833 -3.6818 34.5473
ECC12 GDSC2 2.6058 15.156 -3.202 33.0791
NUGC-4 GDSC2 2.9255 17.377 -4.0386 33.9205
KATO III GDSC2 3.0139 12.8806 -1.7165 27.8445
SNU-1 GDSC2 3.4075 6.8997 1.6038 10.6032
SNU-5 GDSC2 3.6435 15.0195 -2.2611 27.7479
NUGC-3 GDSC2 3.7239 13.6301 -1.5011 25.063
SK-GT-2 GDSC2 4.2476 10.7161 0.3652 15.4741
HGC-27 GDSC2 4.5407 17.2149 -2.6369 26.5495
RF-48 GDSC2 5.914 7.8644 2.683 0.4679
SNG-M GDSC2 4.6955 12.9276 -0.3898 18.0167
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 12 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
K5 GDSC2 -1.1658 5.681 -2.3743 46.7081
CAL-62 GDSC2 -0.4164 6.7429 -2.0183 42.0192
HTC-C3 GDSC2 0.4534 6.8918 -1.1888 35.6645
TT2609-C02 GDSC2 1.5116 14.2285 -3.7048 37.3495
8505C GDSC2 1.5289 15.6692 -4.403 38.3985
BHT-101 GDSC2 2.5938 13.5053 -2.3886 31.1198
B-CPAP GDSC2 2.7738 11.3184 -1.1418 26.5773
IHH-4 GDSC2 2.9194 10.1693 -0.4427 23.2554
8305C GDSC2 3.0274 17.7794 -4.1537 33.8734
ASH-3 GDSC2 3.2175 16.5638 -3.3862 31.8041
FTC-133 GDSC2 4.4028 9.2038 1.2259 10.3001
WRO GDSC2 5.6076 23.8144 -5.0874 29.8794
⏷ Show the Full List of 12 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SAS GDSC2 -0.9974 6.9826 -2.7245 46.0447
Detroit 562 GDSC2 -0.3111 6.3851 -1.7571 40.9579
BB49-HNC GDSC2 0.1784 9.4202 -2.6246 40.3018
SAT [Human HNSCC] GDSC2 0.2758 9.2301 -2.4398 39.5474
HSC-2 GDSC2 0.3142 14.7093 -5.0384 42.8546
HO-1-N-1 GDSC2 0.4255 8.762 -2.0735 38.1399
DOK GDSC2 0.8505 15.5731 -4.9681 41.1306
HSC-3 GDSC2 1.0649 6.8242 -0.5411 30.5689
Ca9-22 GDSC2 1.7381 8.9672 -0.9092 29.2909
SCC-9 GDSC2 2.7635 19.1689 -5.0716 36.0771
JHU-022 GDSC2 3.0855 16.2793 -3.3548 32.0864
UPCI-SCC-090 GDSC2 3.0941 11.7841 -1.1005 25.4223
PCI-04B GDSC2 3.4656 10.9436 -0.3699 21.2515
SKN-3 GDSC2 3.4885 6.5707 1.8342 8.9361
FaDu GDSC2 3.5943 19.3221 -4.4523 33.0271
CAL-27 GDSC2 4.0868 19.3514 -4.0646 31.1051
LB771-HNC GDSC2 4.1738 22.9425 -5.7878 33.963
NCI-H3118 GDSC2 4.2742 13.8173 -1.1548 22.3003
CAL-33 GDSC2 4.6179 11.3563 0.327 14.7384
OSC-20 GDSC2 4.6916 6.9929 2.4631 2.5156
SCC-15 GDSC2 4.9516 10.3582 1.0519 10.0476
BICR 10 GDSC2 4.991 17.3363 -2.3475 24.6305
BICR 78 GDSC2 5.2037 12.979 -0.0424 15.1862
BICR 22 GDSC2 5.7038 13.7692 -0.0746 14.234
SCC-4 GDSC2 5.9489 20.0955 -2.989 24.3905
HSC-4 GDSC2 7.655 19.0713 -1.3006 15.5817
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 14 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KU-19-19 GDSC2 -2.1756 7.0763 -3.9993 52.7425
HT-1197 GDSC2 -0.3597 6.02 -1.6561 41.0023
RT-4 GDSC2 1.0777 11.8906 -2.9513 37.4208
BFTC-905 GDSC2 1.0884 11.7123 -2.8543 37.1911
CAL-29 GDSC2 1.9944 13.2191 -2.7723 33.9521
SW780 GDSC2 4.0732 6.1433 2.4775 3.5162
TCCSUP GDSC2 4.2987 8.9895 1.2552 10.3774
639V GDSC2 4.3001 14.3245 -1.3869 23.108
J82 GDSC2 4.4208 15.3045 -1.78 24.1869
SW1710 GDSC2 4.8655 16.3062 -1.9329 23.6075
RT-112 GDSC2 5.552 15.0754 -0.8158 17.8487
5637 GDSC2 5.6623 17.5658 -1.9562 21.8609
647V GDSC2 5.8137 18.3724 -2.2411 22.4602
HT-1376 GDSC2 6.8108 23.2646 -3.9123 25.0713
⏷ Show the Full List of 14 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 25 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PA-1 GDSC2 -4.3167 5.2049 -5.5952 63.5227
NEC8 GDSC2 -3.5326 1.2763 -3.7157 64.974
BPH-1 GDSC2 -3.1198 5.2634 -4.3199 58.3319
DoTc2 4510 GDSC2 -2.3702 7.6359 -4.4332 53.543
TC-YIK GDSC2 -2.1755 10.3939 -5.4257 52.1167
DSH1 GDSC2 0.0829 10.8424 -3.3896 41.862
ME-180 GDSC2 0.5244 14.4141 -4.6989 41.8496
CAL-39 GDSC2 0.5707 8.6533 -1.8797 37.0546
MS751 GDSC2 0.7565 10.4797 -2.5689 37.8489
PWR-1E GDSC2 1.5191 7.3935 -0.3594 27.9015
HEC-1 GDSC2 1.6329 8.7672 -0.9106 29.6971
PEO1 GDSC2 1.698 16.33 -4.5805 38.1669
SKN GDSC2 1.7264 11.578 -2.2011 33.4321
SKG-IIIa GDSC2 1.921 11.3829 -1.9283 32.0086
Ca Ski GDSC2 2.4235 11.3956 -1.4861 28.9349
OVMIU GDSC2 2.9742 14.4415 -2.5303 30.3762
HeLa GDSC2 3.0701 13.543 -1.9999 28.5755
HEY GDSC2 3.1139 13.3538 -1.8684 28.037
C-33 A GDSC2 3.4539 10.3881 -0.1018 20.0306
HT-3 GDSC2 3.5907 8.6796 0.8637 14.5222
LB831-BLC GDSC2 3.7339 16.9819 -3.1678 29.9506
SiHa GDSC2 3.866 11.7719 -0.4587 20.5059
C-4-I GDSC2 4.1412 9.0525 1.1074 11.6325
SW756 GDSC2 4.189 8.95 1.1937 11.0079
SiSo GDSC2 4.923 11.5431 0.4572 13.3352
⏷ Show the Full List of 25 Cancer Drug Sensitivity Data of This Drug

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)