Details of the Drug

General Information of Drug (ID: DMW87YE)

Drug Name

RG7458

Indication

Disease Entry	ICD 11	Status	REF
Ovarian cancer	2C73	Discontinued in Phase 1	[1]
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Drug Type

Antibody

Cross-matching ID

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Ovarian carcinoma antigen CA125 (MUC16)	TTC1PS3	MUC16_HUMAN	Not Available	[2]

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Molecular Interaction Atlas (MIA)

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Molecular Expression Atlas of This Drug

ICD Disease Classification

02 Neoplasm

Disease Class

ICD-11: 2C82 Prostate cancer

The Studied Tissue

Ovarian tissue

The Studied Disease

Ovarian cancer [ICD-11:2C82]

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Ovarian carcinoma antigen CA125 (MUC16)	DTT	MUC16	4.86E-04	5.02	2.6

Molecular Expression Atlas (MEA)

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800034152)
2	Phase I clinical trail of RG7458 for treating Ovarian cancer. Genentech Inc.