Details of the Drug

General Information of Drug (ID: DMWHP52)

Drug Name

CAT-2200

Synonyms

MEDI-571; Anti-IL-17 antibody (rheumatoid arthritis/systemic lupus erythematosus (SLE)), MedImmune; Anti-IL-17 antibody (rheumatoid arthritis/systemic lupus erythematosus (SLE)), Cambridge Antibody Technology (CAT)

Indication

Disease Entry	ICD 11	Status	REF
Rheumatoid arthritis	FA20	Investigative	[1]
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Drug Type

Antibody

Cross-matching ID

TTD ID: D00XNC

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Interleukin 17 receptor (IL17R)	TT69OHW	I17RA_HUMAN ; I17RB_HUMAN ; I17RC_HUMAN ; I17RD_HUMAN ; I17RE_HUMAN	Not Available	[1]

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Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease

Rheumatoid arthritis

ICD Disease Classification

FA20

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Interleukin 17 receptor (IL17R)	DTT	IL17RA; IL17RB; IL17RC; IL17RD; IL17RE	3.40E-10	-0.23	-0.72

Molecular Expression Atlas (MEA)

MEA Detail

Jump to Detail Molecular Expression Atlas of This Drug

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2294).