Details of the Drug

General Information of Drug (ID: DMWMRLS)

Drug Name
UNC1215
Synonyms
UNC1215; 1415800-43-9; UNC-1215; UNC 1215; (2-(phenylamino)-1,4-phenylene)bis((4-(pyrrolidin-1-yl)piperidin-1-yl)methanone); CHEMBL2426364; 2-Phenylamino-1,4-bis(4-(pyrrolidinyl)piperidinyl)benzamide; [2-(Phenylamino)benzene-1,4-Diyl]bis{[4-(Pyrrolidin-1-Yl)piperidin-1-Yl]methanone}; MLS006011024; GTPL8232; SCHEMBL19730381; CHEBI:95086; EX-A193; AOB4333; MolPort-028-720-812; HMS3652P22; KS-00000T6B; BCP07393; ZINC83253967; s7088; BDBM50440614; 2782AH; AKOS024458279; SB19337; CS-1646; NCGC00344623-12; NCGC00344623-02; SMR004702819
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL is unavailable 2D MOL
#Ro5 Violations (Lipinski): 2 Molecular Weight (mw) 529.7
Logarithm of the Partition Coefficient (xlogp) 5.1
Rotatable Bond Count (rotbonds) 6
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 5
Chemical Identifiers
Formula
C32H43N5O2
IUPAC Name
[3-anilino-4-(4-pyrrolidin-1-ylpiperidine-1-carbonyl)phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone
Canonical SMILES
C1CCN(C1)C2CCN(CC2)C(=O)C3=CC(=C(C=C3)C(=O)N4CCC(CC4)N5CCCC5)NC6=CC=CC=C6
InChI
InChI=1S/C32H43N5O2/c38-31(36-20-12-27(13-21-36)34-16-4-5-17-34)25-10-11-29(30(24-25)33-26-8-2-1-3-9-26)32(39)37-22-14-28(15-23-37)35-18-6-7-19-35/h1-3,8-11,24,27-28,33H,4-7,12-23H2
InChIKey
PQOOIERVZAXHBP-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
57339144
ChEBI ID
CHEBI:95086
CAS Number
1415800-43-9
TTD ID
D0W9RR

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Lethal(3)malignant brain tumor-like 3 (L3MBTL3) TTQDMJN LMBL3_HUMAN Agonist [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
DNA cytosine-5)-methyltransferase 1 (DNMT1) OTM2DGTK DNMT1_HUMAN Protein Interaction/Cellular Processes [2]
Transcription factor SOX-2 (SOX2) OTFAWCAU SOX2_HUMAN Protein Interaction/Cellular Processes [3]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1 2.2471 4.4002 -0.7275 1.1777
EW-3 GDSC1 1.0876 6.1843 -2.2393 13.5194
SK-PN-DW GDSC1 1.4566 3.6849 -0.8169 2.7033
HOS GDSC1 1.6296 3.1436 -0.5093 0.7735
EW-24 GDSC1 1.7302 3.3633 -0.5506 0.8643
A-673 GDSC1 1.7443 3.2023 -0.4835 0.5781
CADO-ES1 GDSC1 1.7629 3.7584 -0.6925 1.5224
CHSA8926 GDSC1 1.792 4.1892 -0.857 2.4107
TC-71 GDSC1 1.8607 3.9013 -0.7043 1.4681
EW-7 GDSC1 1.951 4.5097 -0.9114 2.4955
EW-13 GDSC1 2.0486 3.8523 -0.6022 0.813
CAL-72 GDSC1 2.0901 3.767 -0.5533 0.5978
SJSA-1 GDSC1 2.1963 3.873 -0.5501 0.5219
EW-1 GDSC1 2.2905 4.9214 -0.9152 2.0583
EW-18 GDSC1 2.341 4.7783 -0.8341 1.5847
H-EMC-SS GDSC1 2.3846 4.6458 -0.7629 1.2088
EW-16 GDSC1 2.386 4.6164 -0.7509 1.1548
EW-11 GDSC1 2.444 5.5013 -1.0797 2.7609
SaOS-2 GDSC1 2.526 4.2477 -0.5586 0.3823
ES4 GDSC1 2.5325 4.9128 -0.802 1.2472
ES8 GDSC1 2.5347 4.4513 -0.6282 0.5807
CAL-78 GDSC1 2.543 4.253 -0.5541 0.3638
EW-22 GDSC1 2.5582 4.4043 -0.6021 0.4884
G-292 clone A141B1 GDSC1 2.6104 4.8453 -0.7434 0.9405
ES5 GDSC1 2.6243 5.1322 -0.847 1.3629
SK-ES-1 GDSC1 2.6607 4.3993 -0.5621 0.3369
U2OS GDSC1 2.6969 5.0609 -0.7887 1.0535
CHSA0108 GDSC1 2.7081 4.9571 -0.7452 0.8767
HuO-3N1 GDSC1 2.7296 4.8363 -0.692 0.6758
CHSA0011 GDSC1 2.9507 5.223 -0.7462 0.7243
ES1 GDSC1 2.974 4.5517 -0.5034 0.1415
ES7 GDSC1 2.9793 5.3309 -0.7744 0.802
MHH-ES-1 GDSC1 2.9965 4.6993 -0.5452 0.2007
ES6 GDSC1 3.0855 5.1398 -0.6651 0.4232
HuO9 GDSC1 3.1053 5.5038 -0.7879 0.7708
NY GDSC1 3.4006 5.7739 -0.7716 0.5671
NOS-1 [Human HNSCC] GDSC1 3.4342 5.3429 -0.6104 0.2064
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 154 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC1 1.7528 4.4743 -1.0005 3.3609
A4/Fukuda GDSC1 0.3275 2.2891 -0.8844 5.8736
AMO1 GDSC1 0.7912 2.5962 -0.7129 3.3197
JeKo-1 GDSC1 0.855 3.1243 -0.92 4.6784
A3/Kawakami GDSC1 0.8876 2.2783 -0.5121 1.7403
CML-T1 GDSC1 0.9318 7.2895 -2.9003 18.0991
NU-DUL-1 GDSC1 1.0178 2.6359 -0.5976 2.062
MC116 GDSC1 1.0653 2.3964 -0.47 1.204
NB4 GDSC1 1.149 2.5361 -0.4868 1.185
BE-13 GDSC1 1.1573 3.7406 -1.0163 4.6599
IM-9 GDSC1 1.1656 3.0479 -0.6971 2.4445
EoL-1 GDSC1 1.1683 3.3102 -0.8126 3.2116
DEL GDSC1 1.1895 2.5174 -0.4597 0.9881
P32/ISH GDSC1 1.2069 2.7349 -0.5408 1.4115
SU-DHL-5 GDSC1 1.207 2.8128 -0.5735 1.6028
OCI-AML-5 GDSC1 1.2183 2.4423 -0.4165 0.7407
JVM-3 GDSC1 1.2427 4.3168 -1.2315 6.0023
GA-10 GDSC1 1.2489 2.8047 -0.549 1.3999
KE-37 GDSC1 1.2556 2.9703 -0.6153 1.7793
CMK GDSC1 1.2784 3.1129 -0.6645 2.0434
EM-2 GDSC1 1.284 3.3112 -0.7476 2.5604
Ramos.2G6.4C10 GDSC1 1.3049 4.956 -1.4931 7.7266
OCI-M1 GDSC1 1.3264 3.5165 -0.8146 2.9204
ME1 GDSC1 1.3328 2.7839 -0.5003 1.0301
WIL2 NS GDSC1 1.333 3.1523 -0.6528 1.8859
TK [Human B-cell lymphoma] GDSC1 1.3342 3.1329 -0.644 1.8311
RCH-ACV GDSC1 1.3498 3.7464 -0.9038 3.4706
Karpas-422 GDSC1 1.3665 3.4977 -0.7842 2.6506
BL-41 GDSC1 1.376 3.125 -0.6194 1.6259
MOLT-16 GDSC1 1.3789 3.3779 -0.7254 2.2578
MHH-CALL-2 GDSC1 1.38 3.1183 -0.6147 1.5928
P31/FUJ GDSC1 1.3845 2.8585 -0.5063 1.0024
WSU-DLCL2 GDSC1 1.386 2.8455 -0.5004 0.9715
Karpas-299 GDSC1 1.3951 4.5409 -1.2399 5.7052
MN-60 GDSC1 1.3996 3.7441 -0.8744 3.1791
SU-DHL-10 GDSC1 1.4153 2.3486 -0.302 0.1864
Jurkat GDSC1 1.4322 3.2373 -0.6383 1.6555
MV4-11 GDSC1 1.4406 4.3407 -1.1197 4.7627
Daudi GDSC1 1.4437 3.1527 -0.5976 1.4115
MOLT-4 GDSC1 1.4528 3.4614 -0.7225 2.122
MOLM-16 GDSC1 1.4554 3.5551 -0.7613 2.3557
L-363 GDSC1 1.4695 2.7032 -0.4093 0.4945
Karpas-231 GDSC1 1.4741 2.8572 -0.4659 0.7223
ST486 GDSC1 1.4764 3.2083 -0.6047 1.4082
OCI-AML-3 GDSC1 1.482 3.2268 -0.6096 1.4277
LP-1 GDSC1 1.4891 3.8595 -0.8756 3.0233
Reh GDSC1 1.5114 3.8006 -0.8376 2.7413
Kasumi-1 GDSC1 1.5144 14.3683 -5.9644 28.7055
HL-60 GDSC1 1.5196 3.0417 -0.5178 0.9156
ARH-77 GDSC1 1.5295 6.7526 -2.2023 12.0142
KCL-22 GDSC1 1.543 7.2906 -2.4532 13.5822
K-562 GDSC1 1.5559 3.1463 -0.5427 0.9972
RC-K8 GDSC1 1.5751 8.9437 -3.2367 18.0121
YT GDSC1 1.577 3.4055 -0.6372 1.4568
SK-MM-2 GDSC1 1.5906 3.7786 -0.7863 2.294
HC-1 GDSC1 1.594 3.7899 -0.7893 2.3072
HT GDSC1 1.605 19.5147 -8.4541 33.7454
OCI-AML-2 GDSC1 1.622 3.2771 -0.5646 1.0342
ALL-SIL GDSC1 1.6236 3.44 -0.6291 1.3566
OPM-2 GDSC1 1.6339 3.0736 -0.4807 0.65
CESS GDSC1 1.6434 4.0552 -0.8772 2.7682
CA46 GDSC1 1.6435 4.8302 -1.2218 5.0374
L-1236 GDSC1 1.6439 4.6983 -1.1618 4.6287
U-698-M GDSC1 1.6516 3.8618 -0.7902 2.2245
RL GDSC1 1.6551 4.2154 -0.9406 3.1485
Farage GDSC1 1.661 3.6561 -0.6995 1.6894
ATN-1 GDSC1 1.689 3.2351 -0.5189 0.7635
HAL-01 GDSC1 1.6939 6.1584 -1.8078 8.9493
SU-DHL-16 GDSC1 1.6947 2.8493 -0.3746 0.2561
HEL GDSC1 1.6983 3.1882 -0.4972 0.6657
CRO-AP2 GDSC1 1.699 3.8301 -0.753 1.9392
MHH-PREB-1 GDSC1 1.7069 6.2286 -1.8326 9.0851
BV-173 GDSC1 1.7102 8.3888 -2.8687 15.6048
JVM-2 GDSC1 1.714 4.5038 -1.0349 3.6513
CCRF-CEM GDSC1 1.7194 3.7624 -0.715 1.6985
RPMI-8226 GDSC1 1.7236 4.1835 -0.89 2.7167
Karpas-45 GDSC1 1.725 4.1904 -0.8923 2.7281
ML-2 GDSC1 1.7408 3.8949 -0.7592 1.9169
KM-H2 GDSC1 1.7411 4.5991 -1.0619 3.7773
THP-1 GDSC1 1.7446 3.862 -0.7437 1.8247
L-428 GDSC1 1.7503 3.5267 -0.6055 1.098
KMOE-2 GDSC1 1.7575 3.8446 -0.7303 1.7332
SUP-T1 GDSC1 1.7624 4.1006 -0.8346 2.3223
KMS-11 GDSC1 1.7634 7.8618 -2.576 13.7341
DB GDSC1 1.769 10.7038 -3.9588 20.9658
EJM GDSC1 1.7712 4.1024 -0.8309 2.2875
LAMA-84 GDSC1 1.7784 10.2219 -3.7152 19.8246
SKM-1 GDSC1 1.7785 2.9708 -0.3863 0.2512
MOLP-8 GDSC1 1.779 3.6285 -0.6328 1.2
MOLT-13 GDSC1 1.7873 4.1778 -0.8546 2.4034
RPMI-6666 GDSC1 1.8084 4.7008 -1.0693 3.7034
SUP-M2 GDSC1 1.8245 3.0657 -0.4026 0.274
SU-DHL-8 GDSC1 1.8415 3.3255 -0.4899 0.5352
Raji GDSC1 1.8505 3.6399 -0.6054 0.9986
KOPN-8 GDSC1 1.8615 3.93 -0.7155 1.5254
SU-DHL-4 GDSC1 1.8742 3.2599 -0.4531 0.3936
OCI-Ly19 GDSC1 1.8744 3.7412 -0.6344 1.1094
Loucy GDSC1 1.8752 3.2973 -0.4662 0.4345
P12-Ichikawa GDSC1 1.8853 3.3672 -0.4878 0.4998
EHEB GDSC1 1.8916 5.1821 -1.2361 4.6363
KY821 GDSC1 1.8918 3.4687 -0.5227 0.6206
ROS-50 GDSC1 1.9139 4.7981 -1.0543 3.4239
EB2 GDSC1 1.9251 3.6515 -0.5778 0.8126
NKM-1 GDSC1 1.9271 10.4812 -3.7342 19.5035
U266B1 GDSC1 1.9283 4.1231 -0.7624 1.6913
NOMO-1 GDSC1 1.9393 3.4846 -0.5095 0.5408
MOLM-13 GDSC1 1.9444 3.9531 -0.6866 1.2868
Granta-519 GDSC1 1.9519 4.3163 -0.8302 2.03
Ku812 GDSC1 1.967 3.8823 -0.6487 1.085
Karpas-620 GDSC1 1.9799 3.6885 -0.5689 0.7336
PF-382 GDSC1 1.9996 3.8748 -0.6316 0.9781
NCI-H929 GDSC1 2.0007 3.7485 -0.5829 0.773
JURL-MK1 GDSC1 2.0224 4.3701 -0.8182 1.8731
H9 GDSC1 2.0236 3.7325 -0.5674 0.6952
L-540 GDSC1 2.072 3.7042 -0.5374 0.5539
SUP-B8 GDSC1 2.0877 4.2636 -0.7448 1.4185
697 GDSC1 2.1044 3.5293 -0.462 0.3099
LC4-1 GDSC1 2.1071 4.1331 -0.6849 1.1166
TUR GDSC1 2.1188 3.6305 -0.4925 0.3865
Namalwa GDSC1 2.1233 3.4629 -0.4319 0.2307
KG-1 GDSC1 2.131 4.3586 -0.7629 1.4609
RPMI-8402 GDSC1 2.1494 3.6394 -0.4841 0.3488
MEG-01 GDSC1 2.1642 4.4387 -0.7796 1.5071
SR GDSC1 2.1879 3.6029 -0.4571 0.2649
JJN-3 GDSC1 2.1972 4.2429 -0.6883 1.0497
VL51 GDSC1 2.2106 4.0908 -0.6248 0.7786
VAL GDSC1 2.2338 4.4374 -0.7478 1.2833
DND-41 GDSC1 2.2364 4.3183 -0.7005 1.0682
HDLM-2 GDSC1 2.2668 4.4494 -0.738 1.2064
Sc-1 GDSC1 2.2705 3.7406 -0.4749 0.2763
MLMA GDSC1 2.2719 4.1234 -0.612 0.6876
SU-DHL-6 GDSC1 2.2809 3.798 -0.4912 0.3115
BALL-1 GDSC1 2.3054 3.772 -0.4731 0.2598
Jiyoye GDSC1 2.3245 4.7812 -0.8428 1.6455
SUP-HD1 GDSC1 2.3551 4.6397 -0.7733 1.2833
RS4;11 GDSC1 2.4081 4.0363 -0.5279 0.3525
WSU-NHL GDSC1 2.4133 3.8965 -0.4773 0.2331
Karpas-1106P GDSC1 2.4337 4.2227 -0.5846 0.4999
Hs 445 GDSC1 2.4449 4.2175 -0.5784 0.4755
JSC-1 GDSC1 2.4453 4.4791 -0.674 0.7961
NALM-6 GDSC1 2.448 4.1871 -0.5664 0.4391
P30/OHK GDSC1 2.4497 4.0938 -0.5327 0.3476
DG-75 GDSC1 2.4826 4.3453 -0.61 0.552
RPMI-8866 GDSC1 2.5299 4.2805 -0.5687 0.4076
Mono-Mac-6 GDSC1 2.5394 8.0898 -2.1754 9.364
GDM-1 GDSC1 2.5953 5.0464 -0.8264 1.2981
GR-ST GDSC1 2.6183 5.2496 -0.8955 1.5913
CTV-1 GDSC1 2.6192 4.1191 -0.4805 0.182
HH [Human lymphoma] GDSC1 2.6198 5.3985 -0.9538 1.872
CTB-1 GDSC1 2.678 8.4559 -2.2593 9.5737
QIMR-WIL GDSC1 2.695 4.7441 -0.672 0.6304
PL-21 GDSC1 2.9202 5.2367 -0.7633 0.8006
BC-1 GDSC1 2.9287 15.3415 -5.3881 23.4587
ALL-PO GDSC1 3.0063 5.0573 -0.6655 0.4567
⏷ Show the Full List of 154 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYAE-1 GDSC1 1.7167 4.5482 -1.053 3.7645
ESO-51 GDSC1 1.8409 4.1153 -0.8014 2.0183
OACP4 C GDSC1 1.9735 4.6008 -0.9384 2.6212
ESO-26 GDSC1 2.0138 4.3111 -0.7983 1.7771
KYSE-50 GDSC1 2.1143 3.8254 -0.5651 0.6239
OACM5.1 C GDSC1 2.1259 4.9205 -0.9958 2.733
HCE-4 GDSC1 2.1744 4.3493 -0.7396 1.3038
SK-GT-4 GDSC1 2.448 4.6142 -0.7237 0.9879
KYSE-220 GDSC1 2.4625 4.5964 -0.7109 0.9252
TE-12 GDSC1 3.3273 6.2754 -0.9851 1.3453
FLO-1 GDSC1 3.9823 6.4241 -0.7856 0.3803
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1 2.3682 5.38 -1.0668 2.7935
Cancer Drug Sensitivity Data Curated from 25 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-N-DZ GDSC1 1.4556 2.7794 -0.4439 0.6441
SJNB-7 GDSC1 1.5507 11.1353 -4.334 23.1725
SK-N-MC-IXC GDSC1 1.5722 2.8257 -0.4133 0.4394
SK-N-SH GDSC1 1.5857 4.0945 -0.9256 3.1746
CHP-126 GDSC1 1.6731 4.077 -0.8709 2.6802
Kelly GDSC1 1.7767 3.5623 -0.6077 1.0815
TGW GDSC1 1.7932 3.395 -0.5358 0.7471
SK-N-AS GDSC1 1.7961 3.8392 -0.7096 1.5726
NB(TU)1 GDSC1 1.8507 3.4615 -0.5369 0.7061
SJNB-13 GDSC1 1.885 3.7016 -0.6143 1.0064
SJNB-14 GDSC1 1.9136 3.4939 -0.5233 0.6076
LA-N-6 GDSC1 1.9335 4.044 -0.7279 1.5052
GOTO GDSC1 1.9932 4.301 -0.804 1.8332
CHP-212 GDSC1 2.0356 3.5929 -0.5111 0.4876
SJNB-17 GDSC1 2.0487 4.1563 -0.7199 1.3387
NB1 GDSC1 2.0727 3.4179 -0.4346 0.2548
SK-N-BE(2)-M17 GDSC1 2.1484 4.104 -0.6559 0.9532
SK-N-FI GDSC1 2.1569 4.2057 -0.6914 1.0995
IMR-5 GDSC1 2.2982 12.5213 -4.464 21.6706
KP-N-YN GDSC1 2.3178 4.2115 -0.6262 0.708
SJNB-5 GDSC1 2.3325 4.0207 -0.5508 0.4505
SJNB-12 GDSC1 2.4555 4.2727 -0.5942 0.5177
SJNB-10 GDSC1 2.6972 4.2373 -0.4933 0.1849
SiMa GDSC1 3.0461 5.0968 -0.6646 0.4377
GI-ME-N GDSC1 3.1075 5.7238 -0.8684 1.0552
⏷ Show the Full List of 25 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC1 2.3352 3.8794 -0.4997 0.3112
Cancer Drug Sensitivity Data Curated from 47 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CAL-51 GDSC1 1.1519 3.4001 -0.863 3.5918
CAL-120 GDSC1 1.21 3.4725 -0.8616 3.4622
HCC2157 GDSC1 1.2152 4.0868 -1.1412 5.4194
HCC2218 GDSC1 1.351 9.931 -3.8895 21.8564
DU4475 GDSC1 1.3915 3.4887 -0.7667 2.4959
JIMT-1 GDSC1 1.4298 3.1561 -0.6058 1.475
HCC1419 GDSC1 1.5104 3.0303 -0.5174 0.9228
Hs 578T GDSC1 1.6512 3.9804 -0.8409 2.5312
COLO 824 GDSC1 1.6534 4.2612 -0.9616 3.2861
BT-483 GDSC1 1.7931 3.5113 -0.5805 0.9401
MRK-nu-1 GDSC1 1.8015 3.3938 -0.5319 0.7245
BT-474 GDSC1 1.8121 3.3812 -0.5227 0.6793
HCC202 GDSC1 1.8874 4.0581 -0.7553 1.7038
HCC1428 GDSC1 1.9104 3.5573 -0.5483 0.7052
MDA-MB-453 GDSC1 1.9131 3.6579 -0.5854 0.8545
HDQ-P1 GDSC1 1.9309 3.6213 -0.5639 0.7514
MDA-MB-157 GDSC1 1.9382 4.2343 -0.803 1.8981
MDA-MB-175-VII GDSC1 1.9677 3.8685 -0.643 1.0585
HCC1954 GDSC1 2.0643 3.9778 -0.6434 0.9723
HCC70 GDSC1 2.0754 4.137 -0.7004 1.2182
MFM-223 GDSC1 2.076 3.4967 -0.4611 0.3195
CAMA-1 GDSC1 2.0816 3.9999 -0.6445 0.9619
MDA-MB-436 GDSC1 2.1062 4.2894 -0.7467 1.4078
OCUB-M GDSC1 2.1141 4.2476 -0.7266 1.3029
MCF-7 GDSC1 2.1369 3.9631 -0.6073 0.7655
EFM-192A GDSC1 2.1601 3.8134 -0.5426 0.5183
HCC1187 GDSC1 2.1638 4.5814 -0.8371 1.8003
ZR-75-30 GDSC1 2.1732 4.1389 -0.6587 0.9442
HCC1806 GDSC1 2.2124 3.7211 -0.4895 0.3355
Evsa-T GDSC1 2.237 3.5785 -0.4309 0.1931
MDA-MB-361 GDSC1 2.2439 4.2435 -0.6687 0.9275
HCC1937 GDSC1 2.2992 4.1912 -0.6262 0.7205
UACC-893 GDSC1 2.3693 4.3546 -0.6585 0.7918
BT-20 GDSC1 2.3755 4 -0.5272 0.3646
HCC1500 GDSC1 2.4131 4.3095 -0.6242 0.6394
MDA-MB-330 GDSC1 2.4226 4.4579 -0.6753 0.8172
MDA-MB-468 GDSC1 2.4283 4.2178 -0.5849 0.5037
BT-549 GDSC1 2.438 4.088 -0.535 0.3584
HCC1395 GDSC1 2.4591 4.413 -0.644 0.6786
MDA-MB-231 GDSC1 2.5166 4.325 -0.5896 0.4725
HCC1569 GDSC1 2.5616 5.17 -0.8895 1.6209
MDA-MB-415 GDSC1 2.6283 4.7507 -0.7008 0.7694
HCC38 GDSC1 2.6352 4.4008 -0.572 0.3713
T-47D GDSC1 2.7054 5.5824 -0.988 1.9474
EFM-19 GDSC1 2.9136 5.2879 -0.7848 0.8811
CAL-85-1 GDSC1 3.1428 5.2794 -0.693 0.4706
HCC1143 GDSC1 3.2606 5.333 -0.6685 0.3658
⏷ Show the Full List of 47 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 53 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MOG-G-UVW GDSC1 0.9746 6.4723 -2.4642 15.323
SF539 GDSC1 1.0076 3.1786 -0.8487 3.8026
T98G GDSC1 1.2033 3.6894 -0.9645 4.1906
D283 Med GDSC1 1.3654 3.1865 -0.6507 1.8244
DBTRG-05MG GDSC1 1.3999 3.5621 -0.7941 2.6557
CAS-1 GDSC1 1.4361 3.0051 -0.5412 1.1211
AM-38 GDSC1 1.5206 3.6539 -0.7694 2.3011
DK-MG GDSC1 1.6247 3.1655 -0.5198 0.8242
SF295 GDSC1 1.6269 13.1736 -5.2849 26.392
U-87MG ATCC GDSC1 1.6522 3.2076 -0.5241 0.8183
D-263MG GDSC1 1.6691 3.6799 -0.7054 1.7114
NMC-G1 GDSC1 1.6692 2.9566 -0.4229 0.4124
GB-1 GDSC1 1.683 3.306 -0.5489 0.9005
D-502MG GDSC1 1.6981 4.6625 -1.1143 4.2036
SF126 GDSC1 1.7292 4.0999 -0.8513 2.4723
LN-18 GDSC1 1.7366 3.0095 -0.4158 0.3525
YKG-1 GDSC1 1.7763 3.3497 -0.5257 0.7194
SW1088 GDSC1 1.7813 3.9667 -0.7691 1.9172
Daoy GDSC1 1.806 3.8404 -0.7053 1.5383
M059J GDSC1 1.8733 3.5732 -0.5699 0.8227
MOG-G-CCM GDSC1 1.916 4.1303 -0.7711 1.7533
ONS-76 GDSC1 1.9667 3.9017 -0.6564 1.1206
H4 GDSC1 1.9706 3.8947 -0.6519 1.0964
KNS-42 GDSC1 1.9807 3.4114 -0.4667 0.3796
Becker GDSC1 2.0535 3.7732 -0.5704 0.6851
LN-405 GDSC1 2.0612 3.4587 -0.4532 0.3051
LNZTA3WT4 GDSC1 2.0618 3.73 -0.551 0.608
SF268 GDSC1 2.092 4.6109 -0.8835 2.1401
LN-229 GDSC1 2.1145 3.9058 -0.595 0.7345
U-118MG GDSC1 2.1351 3.9278 -0.5948 0.7186
D-542MG GDSC1 2.1354 4.025 -0.6313 0.8618
8-MG-BA GDSC1 2.1372 3.5963 -0.4735 0.3257
GaMG GDSC1 2.1673 3.7578 -0.5197 0.4422
A-172 GDSC1 2.169 3.8054 -0.5362 0.4926
Hs 683 GDSC1 2.177 3.7993 -0.5309 0.4715
D-336MG GDSC1 2.2062 11.1034 -3.8378 19.2357
Onda 10 GDSC1 2.2114 4.3874 -0.7382 1.2604
YH-13 GDSC1 2.2299 3.9253 -0.556 0.5216
42-MG-BA GDSC1 2.296 4.2575 -0.6522 0.8213
U-251MG GDSC1 2.3083 4.015 -0.5581 0.485
SK-MG-1 GDSC1 2.3299 3.9308 -0.5198 0.3646
SW1783 GDSC1 2.366 4.67 -0.7803 1.3049
GI-1 GDSC1 2.5632 4.2009 -0.5285 0.2943
D-423MG GDSC1 2.5946 5.1781 -0.878 1.5329
D-392MG GDSC1 2.6431 5.8479 -1.1255 2.7457
KINGS-1 GDSC1 2.6686 4.7295 -0.677 0.6623
KNS-81-FD GDSC1 2.693 4.3167 -0.5218 0.2384
Onda 11 GDSC1 2.6985 4.7685 -0.6795 0.6528
D-247MG GDSC1 2.7238 4.5957 -0.6078 0.4267
D-566MG GDSC1 2.726 4.3413 -0.5185 0.2226
KS-1 [Human Krukenberg tumour] GDSC1 2.7531 4.9631 -0.7292 0.7886
SNB-75 GDSC1 2.826 4.8271 -0.6515 0.5001
KALS-1 GDSC1 2.8887 5.1111 -0.7297 0.7065
⏷ Show the Full List of 53 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TGBC1TKB GDSC1 1.4396 3.4986 -0.7453 2.2824
TGBC24TKB GDSC1 1.5787 3.4306 -0.6466 1.5056
ETK-1 GDSC1 3.024 4.9734 -0.6295 0.3611
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
EN GDSC1 1.8167 3.4292 -0.5389 0.741
ESS-1 GDSC1 1.8798 3.6247 -0.5868 0.8896
MFE-319 GDSC1 2.1103 3.7144 -0.526 0.4933
MFE-296 GDSC1 2.2171 3.9863 -0.5834 0.6215
RL95-2 GDSC1 2.2426 3.9035 -0.5431 0.4742
AN3-CA GDSC1 2.5367 4.191 -0.5347 0.3185
KLE GDSC1 2.5673 4.5285 -0.6435 0.6114
MFE-280 GDSC1 3.1513 5.4784 -0.7608 0.6585
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BFTC-909 GDSC1 1.4182 4.4386 -1.1783 5.2201
NCC010 GDSC1 1.5192 5.9337 -1.8163 9.4476
KTCTL-26A GDSC1 1.5278 8.2931 -2.9525 16.5965
RCC10RGB GDSC1 1.704 3.0647 -0.4487 0.479
SN12C GDSC1 1.7973 3.6611 -0.6375 1.2034
KTCTL-1M GDSC1 1.804 4.0062 -0.7743 1.916
OS-RC-2 GDSC1 1.8092 11.9789 -4.5566 23.3302
A-498 GDSC1 1.8313 3.299 -0.4842 0.5216
BB65-RCC GDSC1 1.8456 3.7467 -0.6496 1.211
LB2241-RCC GDSC1 1.874 4.4132 -0.9099 2.6019
CAL-54 GDSC1 1.9054 3.6411 -0.5822 0.8477
A-704 GDSC1 1.9668 4.2117 -0.7801 1.7381
SW156 GDSC1 1.9995 5.3571 -1.2529 4.5414
VMRC-RCZ GDSC1 2.0101 3.6959 -0.5592 0.6739
UO-31 GDSC1 2.1071 4.6176 -0.8789 2.095
ACHN GDSC1 2.1235 3.9904 -0.6232 0.8386
SW13 GDSC1 2.1927 3.84 -0.5395 0.4901
RXF 393L GDSC1 2.2122 4.7227 -0.8715 1.9227
NCC021 GDSC1 2.3107 4.309 -0.6656 0.8623
KMRC-20 GDSC1 2.3268 4.1863 -0.6133 0.6559
KTCTL-195 GDSC1 2.35 4.3336 -0.6586 0.8061
769-P GDSC1 2.4334 14.1044 -5.1413 23.8254
KTCTL-13 GDSC1 2.4675 4.5268 -0.6827 0.8131
KTCTL-21 GDSC1 2.5898 4.8347 -0.7479 0.9741
LB1047-RCC GDSC1 2.6717 4.9147 -0.7442 0.8987
LB996-RCC GDSC1 2.728 4.6277 -0.6175 0.4512
786-O GDSC1 2.7571 4.4573 -0.5472 0.2704
KTCTL-140 GDSC1 2.867 5.1034 -0.7355 0.7386
TK-10 GDSC1 2.8896 5.2488 -0.78 0.8799
Caki-1 GDSC1 2.8966 7.8801 -1.8681 6.7417
HA7-RCC GDSC1 2.9781 4.9443 -0.6362 0.3941
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 45 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MDST8 GDSC1 1.0492 5.4197 -1.893 11.2696
LS1034 GDSC1 1.3409 3.3523 -0.7346 2.3787
SW1116 GDSC1 1.4299 2.9933 -0.5394 1.1188
SK-CO-1 GDSC1 1.5487 3.4944 -0.6876 1.7748
COLO205 GDSC1 1.5716 3.5658 -0.7061 1.8488
SNU-C1 GDSC1 1.5968 6.6444 -2.1041 11.1877
SW948 GDSC1 1.6107 3.0251 -0.4721 0.6336
SNU-61 GDSC1 1.6653 4.386 -1.0099 3.5779
HT115 GDSC1 1.6867 3.2114 -0.5108 0.7313
HCT 116 GDSC1 1.6896 4.455 -1.0269 3.6439
HCT 15 GDSC1 1.7546 3.4386 -0.5691 0.9248
HCC2998 GDSC1 1.7595 3.8461 -0.7299 1.7285
HT-29 GDSC1 1.7738 3.0478 -0.4153 0.3323
NCI-H716 GDSC1 1.7815 4.4019 -0.9535 3.0155
LS411N GDSC1 1.7999 2.9794 -0.3814 0.2307
SW1417 GDSC1 1.8025 3.9956 -0.7706 1.8974
SW1463 GDSC1 1.8094 3.549 -0.5881 0.9589
NCI-H508 GDSC1 1.8363 9.5378 -3.3386 17.8078
C2BBe1 GDSC1 1.8792 3.8163 -0.6619 1.2354
RCM-1 [Human ESC] GDSC1 1.9094 3.2842 -0.4483 0.3614
SNU-1040 GDSC1 1.9459 9.3265 -3.1579 16.5598
LS513 GDSC1 1.9765 3.4838 -0.4945 0.4677
COLO 320HSR GDSC1 2.0074 4.9432 -1.0671 3.3472
KM12 GDSC1 2.0476 3.6429 -0.5246 0.5254
SNU-81 GDSC1 2.0831 3.5515 -0.4779 0.3621
SW48 GDSC1 2.1264 4.3972 -0.7803 1.5526
GP5d GDSC1 2.2264 3.9252 -0.5573 0.528
SW837 GDSC1 2.2559 4.202 -0.6479 0.8346
CCK-81 GDSC1 2.2911 4.4408 -0.7241 1.1225
DiFi GDSC1 2.3128 4.5059 -0.7399 1.1723
LS123 GDSC1 2.3407 4.0405 -0.5548 0.4583
T84 GDSC1 2.3511 4.3127 -0.6503 0.774
RKO GDSC1 2.3596 3.9996 -0.533 0.3872
LS180 GDSC1 2.366 3.9835 -0.5249 0.3627
LoVo GDSC1 2.3736 4.6373 -0.7643 1.2254
CW-2 GDSC1 2.4695 4.1455 -0.5436 0.3672
CaR-1 GDSC1 2.5296 4.3761 -0.603 0.5053
SNU-C5 GDSC1 2.6581 4.5752 -0.6253 0.5064
SW620 GDSC1 2.7016 4.2172 -0.4849 0.1699
COLO 678 GDSC1 2.7143 4.5912 -0.6097 0.4361
SW626 GDSC1 2.7155 4.6185 -0.6189 0.4607
SNU-407 GDSC1 2.8306 4.9779 -0.704 0.6564
NCI-H747 GDSC1 2.8539 5.0386 -0.717 0.685
CL-11 GDSC1 3.0577 5.315 -0.7379 0.6382
SNU-C2B GDSC1 4.0667 6.4282 -0.7571 0.3018
⏷ Show the Full List of 45 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1 2.2939 4.0498 -0.5762 0.5506
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHH-6 GDSC1 0.3719 1.9268 -0.6738 4.1091
JHH-4 GDSC1 1.4296 4.1214 -1.0264 4.1434
JHH-1 GDSC1 1.5011 2.7359 -0.4087 0.4699
SNU-449 GDSC1 1.6791 3.6337 -0.6815 1.5678
Hep 3B2.1-7 GDSC1 1.706 3.3704 -0.5639 0.9467
SK-HEP-1 GDSC1 1.8759 3.3078 -0.4698 0.4455
Hep-G2/C3A GDSC1 1.9362 3.478 -0.5083 0.5387
HuH-1 GDSC1 2.0293 3.3598 -0.4302 0.2607
HLE GDSC1 2.096 3.9392 -0.6153 0.8284
JHH-7 GDSC1 2.1292 3.9373 -0.6008 0.7458
SNU-387 GDSC1 2.191 4.5006 -0.792 1.5394
SNU-423 GDSC1 2.4025 4.4686 -0.6876 0.8793
Huh-7 GDSC1 2.4725 4.2713 -0.5872 0.4875
SNU-398 GDSC1 2.6661 4.8474 -0.7214 0.8183
JHH-2 GDSC1 2.7776 4.614 -0.5942 0.3698
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 172 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H460 GDSC1 -0.0635 1.0118 -0.5597 4.6498
NCI-H2405 GDSC1 0.1641 2.7122 -1.2219 9.0457
SHP-77 GDSC1 0.6153 2.6577 -0.8576 4.8322
NCI-H1781 GDSC1 0.6296 2.6468 -0.8426 4.6806
NCI-H1436 GDSC1 0.9214 10.5178 -4.5121 25.7291
COR-L279 GDSC1 0.9567 3.2033 -0.8918 4.2276
NCI-H345 GDSC1 1.0342 2.2365 -0.4192 0.9626
NCI-H1581 GDSC1 1.1074 3.1043 -0.7553 2.9424
NCI-H1694 GDSC1 1.1699 2.9153 -0.6368 2.0496
SBC-5 GDSC1 1.2412 2.8558 -0.5743 1.5567
NCI-H596 GDSC1 1.2447 2.9882 -0.6286 1.877
NCI-H2009 GDSC1 1.2663 3.8041 -0.979 4.1571
NCI-H226 GDSC1 1.2945 2.5999 -0.4445 0.7962
BEN GDSC1 1.3497 2.3223 -0.3172 0.2562
HCC78 GDSC1 1.3807 3.4084 -0.7376 2.3312
NCI-H2444 GDSC1 1.4114 2.6618 -0.4178 0.5719
NCI-H2081 GDSC1 1.4152 5.1976 -1.5352 7.7485
IST-SL1 GDSC1 1.4305 4.0969 -1.0148 4.0623
NCI-H524 GDSC1 1.4346 3.4182 -0.7135 2.0958
NCI-H1573 GDSC1 1.4416 3.6746 -0.8206 2.7529
CPC-N GDSC1 1.4546 3.7431 -0.8434 2.8771
NCI-H810 GDSC1 1.4677 3.1873 -0.6003 1.3952
Lu-65 GDSC1 1.4803 3.607 -0.7704 2.3719
SBC-1 GDSC1 1.4916 6.5354 -2.1236 11.5997
Lu-139 GDSC1 1.4952 3.4363 -0.6901 1.8656
NCI-H1651 GDSC1 1.4954 4.597 -1.2041 5.231
DMS 79 GDSC1 1.5093 4.4511 -1.129 4.6819
LCLC-97TM1 GDSC1 1.5135 4.4168 -1.111 4.5497
NCI-H1770 GDSC1 1.5137 3.461 -0.6912 1.8449
NCI-H1304 GDSC1 1.5203 3.736 -0.8049 2.5204
KNS-62 GDSC1 1.5404 7.3019 -2.4605 13.6349
NCI-H2227 GDSC1 1.5888 4.1434 -0.9454 3.2969
DMS 53 GDSC1 1.5889 4.3969 -1.058 4.0395
NCI-H146 GDSC1 1.5893 3.3209 -0.5971 1.231
NCI-H1693 GDSC1 1.5923 3.7125 -0.7573 2.1182
NCI-H187 GDSC1 1.5938 3.0493 -0.4884 0.7149
NCI-H1092 GDSC1 1.6031 3.9031 -0.833 2.5597
IA-LM GDSC1 1.6053 3.7077 -0.7487 2.0481
NCI-H1435 GDSC1 1.6114 3.4524 -0.6399 1.4287
COR-L23 GDSC1 1.6131 3.1749 -0.5285 0.8739
COR-L32 GDSC1 1.6271 3.8087 -0.7803 2.2023
NCI-H2135 GDSC1 1.6552 3.0753 -0.4725 0.601
NCI-H727 GDSC1 1.6668 4.2546 -0.9513 3.1968
NCI-H847 GDSC1 1.6842 3.1531 -0.4898 0.6472
NCI-H196 GDSC1 1.7078 3.3507 -0.5554 0.9067
NCI-H2461 GDSC1 1.7099 4.1364 -0.877 2.6589
Ms-1 GDSC1 1.7292 3.8945 -0.7648 1.9645
NCI-H835 GDSC1 1.7317 4.6311 -1.0813 3.9216
NCI-H1876 GDSC1 1.7484 6.8727 -2.1111 10.8382
NCI-H526 GDSC1 1.7493 3.4798 -0.5875 1.014
NCI-H1688 GDSC1 1.7518 3.7116 -0.6787 1.4636
NCI-H211 GDSC1 1.7527 10.2468 -3.7463 20.0423
NCI-H1836 GDSC1 1.7622 3.3603 -0.5357 0.7723
NCI-H1341 GDSC1 1.7685 3.4696 -0.5751 0.9387
NCI-H720 GDSC1 1.7754 3.0745 -0.4243 0.358
Lu-135 GDSC1 1.804 4.3296 -0.9106 2.7144
LCLC-103H GDSC1 1.8066 3.0931 -0.4191 0.3271
NCI-H2122 GDSC1 1.8169 3.121 -0.4251 0.3396
NCI-H1105 GDSC1 1.8292 3.8808 -0.7108 1.5392
NCI-H1048 GDSC1 1.8381 3.4296 -0.5301 0.6888
NCI-H2141 GDSC1 1.8454 9.7757 -3.4483 18.3398
NCI-H1623 GDSC1 1.8465 3.738 -0.6457 1.1914
NCI-H1944 GDSC1 1.8501 3.8009 -0.669 1.3016
HOP-62 GDSC1 1.8676 3.6901 -0.6174 1.0372
COR-L88 GDSC1 1.8774 4.1479 -0.797 1.9444
NCI-H322M GDSC1 1.8839 4.3849 -0.8928 2.4855
NCI-H1993 GDSC1 1.8858 4.1529 -0.795 1.922
PC-14 GDSC1 1.886 3.8241 -0.6619 1.2285
IST-SL2 GDSC1 1.9027 7.0768 -2.1061 10.4149
COR-L321 GDSC1 1.9069 3.4171 -0.4975 0.5199
NCI-H1155 GDSC1 1.9083 3.4013 -0.4911 0.4972
NCI-H292 GDSC1 1.9121 3.5246 -0.5353 0.6539
DMS 273 GDSC1 1.9156 3.7156 -0.6064 0.9432
NCI-H1755 GDSC1 1.9172 4.3777 -0.873 2.3209
NCI-H441 GDSC1 1.9195 3.9405 -0.6929 1.3444
NCI-H2066 GDSC1 1.9296 3.7944 -0.6309 1.0393
NCI-H2030 GDSC1 1.941 3.9047 -0.669 1.2056
NCI-H69 GDSC1 1.9557 4.2516 -0.8017 1.8684
EKVX GDSC1 1.9635 14.8604 -5.864 27.2669
NCI-H209 GDSC1 1.9663 6.1256 -1.6205 7.0474
NCI-H3255 GDSC1 1.9753 4.2159 -0.7778 1.7154
NCI-H2023 GDSC1 1.994 4.0284 -0.694 1.2707
NCI-H2803 GDSC1 1.9979 3.8851 -0.6363 1.0005
NCI-H838 GDSC1 2.0135 3.5013 -0.4864 0.422
HOP-92 GDSC1 2.0244 8.2 -2.5603 12.9519
NCI-H1975 GDSC1 2.0267 3.6357 -0.5302 0.5576
HCC366 GDSC1 2.0543 4.0793 -0.6871 1.1774
NCI-H2369 GDSC1 2.0579 3.7768 -0.5699 0.6802
Lu-134-A GDSC1 2.0701 5.2641 -1.1728 3.9016
COR-L95 GDSC1 2.0709 3.3701 -0.4187 0.2194
NCI-H2085 GDSC1 2.0795 4.2461 -0.7416 1.4117
NCI-H1666 GDSC1 2.1099 4.1092 -0.6744 1.0671
NCI-H82 GDSC1 2.1181 3.829 -0.5649 0.6207
LK-2 GDSC1 2.1267 3.8035 -0.5521 0.5705
LOU-NH91 GDSC1 2.1351 4.0878 -0.6554 0.9623
NCI-H1793 GDSC1 2.1482 3.9599 -0.6014 0.7346
EPLC-272H GDSC1 2.1565 4.2558 -0.711 1.1884
NCI-H661 GDSC1 2.16 4.9234 -0.9799 2.5907
NCI-H358 GDSC1 2.1665 4.0657 -0.6337 0.8469
NCI-H2029 GDSC1 2.1777 3.6985 -0.4945 0.3643
NCI-H290 GDSC1 2.1812 4.0006 -0.6031 0.7173
ChaGo-K-1 GDSC1 2.1881 4.317 -0.7209 1.2036
SK-MES-1 GDSC1 2.2041 4.0147 -0.5991 0.6866
CAL-12T GDSC1 2.216 4.2969 -0.701 1.0888
NCI-H2869 GDSC1 2.2312 4.4337 -0.7475 1.2844
UMC-11 GDSC1 2.2326 3.7194 -0.4814 0.3065
NCI-H1792 GDSC1 2.2649 4.0283 -0.5798 0.5797
RERF-LC-MS GDSC1 2.2743 4.0142 -0.571 0.5448
NCI-H2373 GDSC1 2.2782 4.2443 -0.6546 0.844
NCI-H2291 GDSC1 2.2847 4.3093 -0.6765 0.9266
RERF-LC-KJ GDSC1 2.2882 3.9287 -0.5347 0.4256
NCI-H650 GDSC1 2.3046 4.0094 -0.5574 0.485
NCI-H2342 GDSC1 2.305 4.4736 -0.7308 1.1393
NCI-H2172 GDSC1 2.3063 3.6885 -0.444 0.1986
HCC15 GDSC1 2.3148 18.6114 -7.454 30.313
NCI-H522 GDSC1 2.326 4.5125 -0.7367 1.1463
NCI-H1703 GDSC1 2.3281 4.1405 -0.5959 0.5955
COR-L105 GDSC1 2.3329 5.5272 -1.1469 3.3127
NCI-H23 GDSC1 2.3337 4.4319 -0.7025 0.9935
SK-LU-1 GDSC1 2.3436 4.1824 -0.6051 0.6173
NCI-H1563 GDSC1 2.3815 4.03 -0.5356 0.3843
NCI-H2795 GDSC1 2.3847 4.5218 -0.7152 1.0043
LB647-SCLC GDSC1 2.385 4.0484 -0.5408 0.397
ABC-1 GDSC1 2.394 4.9798 -0.8903 1.8059
NCI-H1838 GDSC1 2.399 4.1001 -0.5539 0.4269
HARA [Human squamous cell lung carcinoma] GDSC1 2.4001 4.1109 -0.5573 0.4362
LXF 289 GDSC1 2.4011 4.3377 -0.6394 0.7
EBC-1 GDSC1 2.4139 4.1362 -0.5611 0.4404
NCI-H1437 GDSC1 2.4295 4.6569 -0.7478 1.1035
EMC-BAC-2 GDSC1 2.4484 4.7676 -0.7823 1.2365
HCC827 GDSC1 2.4545 4.1932 -0.5661 0.4351
NCI-H1568 GDSC1 2.469 4.2178 -0.5694 0.4375
NCI-H2087 GDSC1 2.4745 4.5628 -0.6933 0.848
NCI-H446 GDSC1 2.4822 4.7105 -0.7459 1.0514
NCI-H2810 GDSC1 2.4922 4.8928 -0.8117 1.3275
NCI-H3122 GDSC1 2.4962 4.3632 -0.6112 0.5484
NCI-H2722 GDSC1 2.5096 4.5888 -0.6887 0.8057
HCC44 GDSC1 2.5143 4.4739 -0.6444 0.6459
Calu-6 GDSC1 2.5716 4.5961 -0.6665 0.6858
NCI-H513 GDSC1 2.5913 4.2636 -0.5401 0.3109
DMS 114 GDSC1 2.5973 4.2127 -0.5203 0.2648
LC-2/ad GDSC1 2.6045 4.9933 -0.802 1.1844
COLO 668 GDSC1 2.6091 4.7076 -0.6926 0.7528
VMRC-LCD GDSC1 2.6122 4.2816 -0.5388 0.3003
EMC-BAC-1 GDSC1 2.6297 4.9858 -0.7885 1.1064
NCI-H1915 GDSC1 2.635 4.1034 -0.4697 0.1605
NCI-H2170 GDSC1 2.6683 4.235 -0.5026 0.2088
Calu-3 GDSC1 2.6714 4.6366 -0.6422 0.5502
SW1271 GDSC1 2.6733 4.5911 -0.6252 0.4985
NCI-H1648 GDSC1 2.6884 4.974 -0.7595 0.9452
NCI-H2595 GDSC1 2.6892 5.2455 -0.8627 1.373
PaCa-3 GDSC1 2.6926 4.6871 -0.6523 0.5697
NCI-H2110 GDSC1 2.7329 5.0824 -0.7819 0.9986
RERF-LC-Sq1 GDSC1 2.7442 5.2409 -0.8373 1.2147
NCI-H841 GDSC1 2.7591 4.5717 -0.5862 0.3574
NCI-H2347 GDSC1 2.7642 5.6808 -1.0003 1.9437
Lu-99A GDSC1 2.7946 5.3907 -0.8732 1.3244
A-549 GDSC1 2.8275 5.0115 -0.7174 0.7021
NCI-H520 GDSC1 2.8514 4.769 -0.6214 0.408
NCI-H2731 GDSC1 2.8894 4.7866 -0.6136 0.3735
NCI-H2818 GDSC1 2.8915 4.7467 -0.5989 0.3382
LC-1/sq GDSC1 2.8984 5.2376 -0.7723 0.8463
NCI-H2804 GDSC1 2.9055 5.1485 -0.7368 0.7199
NCI-H1299 GDSC1 2.92 4.5981 -0.5377 0.2064
SBC-3 GDSC1 2.9203 4.7198 -0.5792 0.2854
SW1573 GDSC1 2.9546 5.2887 -0.7687 0.7977
A-427 GDSC1 2.9687 5.6104 -0.8832 1.2195
NCI-H1869 GDSC1 2.998 4.8134 -0.5836 0.2707
NCI-H1355 GDSC1 3.0722 5.5783 -0.8285 0.9322
Lu-165 GDSC1 3.1776 14.236 -4.6754 20.3501
NCI-H647 GDSC1 3.1899 5.3666 -0.7063 0.4851
NCI-H2591 GDSC1 3.3721 8.9032 -2.0547 6.9795
⏷ Show the Full List of 172 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1 1.5213 5.5902 -1.6517 8.302
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE-15 GDSC1 1.372 4.1254 -1.0625 4.5123
EC-GI-10 GDSC1 1.4071 5.1305 -1.5087 7.5815
TE-1 GDSC1 1.4593 3.8271 -0.8778 3.0912
KYSE-150 GDSC1 1.7899 3.5456 -0.5953 1.0102
KYSE-450 GDSC1 1.7909 3.3498 -0.5196 0.6835
TE-5 GDSC1 1.8274 3.7022 -0.6402 1.1846
OE33 GDSC1 1.8788 3.704 -0.618 1.0289
KYSE-180 GDSC1 1.9104 3.8611 -0.6655 1.2205
TE-11 GDSC1 1.9391 3.7332 -0.6031 0.9079
TE-9 GDSC1 1.9733 3.8798 -0.645 1.062
OE19 GDSC1 2.0994 3.377 -0.4108 0.1939
COLO 680N GDSC1 2.1378 3.7517 -0.5289 0.4867
KYSE-510 GDSC1 2.1794 3.8443 -0.5463 0.5192
TE-6 GDSC1 2.1887 4.46 -0.7769 1.4677
TE-10 GDSC1 2.3803 4.1588 -0.5821 0.5208
TE-8 GDSC1 2.414 4.4989 -0.6943 0.8968
OE21 GDSC1 2.4312 4.7473 -0.7819 1.2506
KYSE-520 GDSC1 2.4494 5.5438 -1.0947 2.8383
KYSE-70 GDSC1 2.4786 4.213 -0.564 0.4181
T.T GDSC1 2.4807 4.3127 -0.599 0.5188
TE-4 GDSC1 2.5701 4.4586 -0.6171 0.5269
KYSE-270 GDSC1 3.1379 5.1122 -0.6364 0.3366
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OC 314 GDSC1 1.2285 3.733 -0.9692 4.1693
OVCAR-5 GDSC1 1.2525 3.3034 -0.7616 2.7085
IGROV-1 GDSC1 1.3121 5.25 -1.6284 8.6722
OV56 GDSC1 1.4931 2.6648 -0.3856 0.3935
TOV-21G GDSC1 1.6126 3.0225 -0.4703 0.6249
A2780 GDSC1 1.6433 4.1468 -0.917 3.019
JHOS-2 GDSC1 1.7564 4.1517 -0.8594 2.479
Caov-4 GDSC1 1.8372 4.2882 -0.8758 2.4542
OAW42 GDSC1 1.8984 2.9656 -0.3415 0.1207
OVISE GDSC1 1.9051 3.3089 -0.4588 0.3949
SK-OV-3 GDSC1 1.9627 3.7052 -0.5824 0.8011
EFO-21 GDSC1 1.965 3.6251 -0.5512 0.676
JHOS-4 GDSC1 2.0775 3.9552 -0.6291 0.9004
OV-90 GDSC1 2.102 4.2518 -0.7337 1.3492
FU-OV-1 GDSC1 2.1028 4.8231 -0.9665 2.5956
OVKATE GDSC1 2.1322 3.699 -0.512 0.4373
TYK-nu GDSC1 2.2098 3.6572 -0.468 0.2827
OVCAR-8 GDSC1 2.2142 3.7926 -0.5142 0.4026
OVCAR-3 GDSC1 2.2393 3.8156 -0.5129 0.387
OVK18 GDSC1 2.2475 3.931 -0.5512 0.4965
ES-2 GDSC1 2.2576 4.0006 -0.5726 0.5599
TOV-112D GDSC1 2.2764 4.3019 -0.6772 0.9361
RMG-I GDSC1 2.2902 4.5087 -0.7508 1.2423
Kuramochi GDSC1 2.3667 4.6115 -0.7573 1.2006
OVCAR-4 GDSC1 2.3957 4.4283 -0.6753 0.8365
EFO-27 GDSC1 2.4498 4.0761 -0.5264 0.3318
DOV13 GDSC1 2.491 4.0025 -0.486 0.227
OVTOKO GDSC1 2.9379 4.9827 -0.6647 0.4847
OAW28 GDSC1 3.4462 5.5357 -0.6718 0.3129
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MIA PaCa-2 GDSC1 0.6521 2.8246 -0.9127 5.1495
PSN1 GDSC1 1.1164 3.1394 -0.7658 2.996
MZ-PC-1 GDSC1 1.3925 9.9775 -3.8811 21.6961
KP-4 GDSC1 1.5247 3.3321 -0.6322 1.4967
YAPC GDSC1 1.5287 3.0001 -0.4975 0.8131
KP-2 GDSC1 1.5755 3.3238 -0.6046 1.2862
SU.86.86 GDSC1 1.6722 3.1215 -0.4828 0.6286
PaTu 8988t GDSC1 1.7167 3.2102 -0.4978 0.6539
PaTu 8902 GDSC1 1.7421 3.2501 -0.5023 0.6522
KP-1N GDSC1 1.768 4.0062 -0.7921 2.0667
CFPAC-1 GDSC1 1.8056 3.4565 -0.554 0.8132
QGP-1 GDSC1 1.9808 3.6964 -0.5715 0.7432
SUIT-2 GDSC1 2.1084 3.725 -0.5306 0.5093
Panc 03.27 GDSC1 2.1132 3.8768 -0.5847 0.6964
SW1990 GDSC1 2.301 4.3497 -0.685 0.9482
Panc 10.05 GDSC1 2.409 4.4851 -0.6911 0.8882
Panc 08.13 GDSC1 2.5046 4.5083 -0.6609 0.7088
Hs 766T GDSC1 2.5107 4.4357 -0.6319 0.6064
HPAF-II GDSC1 2.5495 4.1871 -0.5287 0.2997
HuP-T3 GDSC1 2.5818 4.8866 -0.7709 1.073
Panc 02.03 GDSC1 2.7358 4.572 -0.5949 0.3883
PL4 GDSC1 2.7409 4.6581 -0.6234 0.4615
Capan-2 GDSC1 2.8044 4.8913 -0.6828 0.604
BxPC-3 GDSC1 3.0148 5.0124 -0.6465 0.4051
KP-3 GDSC1 3.1377 5.667 -0.835 0.9121
AsPC-1 GDSC1 3.6031 5.9857 -0.771 0.4797
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 4 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IST-Mes1 GDSC1 1.9402 3.8683 -0.6551 1.1407
NCI-H2452 GDSC1 2.1772 4.33 -0.7308 1.2599
MPP 89 GDSC1 2.2006 4.0896 -0.6286 0.8005
NCI-H28 GDSC1 2.406 4.484 -0.692 0.8938
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
VCaP GDSC1 1.9418 3.7563 -0.6108 0.9391
22Rv1 GDSC1 2.0589 4.8329 -0.993 2.816
PC-3 GDSC1 2.2545 4.6542 -0.8242 1.6301
DU145 GDSC1 2.2855 4.3031 -0.6738 0.915
LNCaP clone FGC GDSC1 3.0126 5.0811 -0.6715 0.47
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1 2.4844 4.0043 -0.4889 0.235
Cancer Drug Sensitivity Data Curated from 54 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-MEL-28 GDSC1 1.0691 2.1162 -0.355 0.6008
SK-MEL-1 GDSC1 1.1725 2.7419 -0.5611 1.5808
Hs 938.T GDSC1 1.3702 3.3362 -0.712 2.189
COLO 783 GDSC1 1.3825 3.6536 -0.8439 3.0099
SK-MEL-31 GDSC1 1.4892 4.0823 -0.9743 3.6732
SK-MEL-2 GDSC1 1.5113 2.6375 -0.3685 0.3273
WT2-iPS GDSC1 1.5119 2.8436 -0.4446 0.6008
LB373-MEL-D GDSC1 1.5753 2.7407 -0.3811 0.3317
IPC-298 GDSC1 1.6111 2.9275 -0.4353 0.4922
VMRC-MELG GDSC1 1.629 2.9197 -0.4253 0.445
CP50-MEL-B GDSC1 1.629 3.7734 -0.7644 2.1055
SK-MEL-30 GDSC1 1.6575 2.8346 -0.3833 0.2967
RVH-421 GDSC1 1.6575 3.5311 -0.65 1.4258
UACC-257 GDSC1 1.7112 3.2189 -0.5034 0.6806
WM1552C GDSC1 1.7211 3.4642 -0.5939 1.0725
MZ-MEL-2 GDSC1 1.7218 4.7042 -1.1194 4.1918
LB2518-MEL GDSC1 1.7293 3.0351 -0.4279 0.3941
GAK GDSC1 1.779 3.3331 -0.5183 0.6875
CP66-MEL GDSC1 1.8109 3.366 -0.5174 0.6595
WM115 GDSC1 1.8628 3.4249 -0.5182 0.6244
UACC-62 GDSC1 1.8646 3.0966 -0.3986 0.2476
A101D GDSC1 1.9006 3.0827 -0.3807 0.1938
M14 GDSC1 1.9092 3.8433 -0.659 1.1905
IGR-37 GDSC1 1.925 3.497 -0.5198 0.5871
MMAc-SF GDSC1 1.9504 3.339 -0.4523 0.3528
MZ-MEL-7 GDSC1 1.9524 3.9106 -0.6662 1.1808
Mel Ho GDSC1 1.9698 3.6808 -0.5702 0.7462
HT-144 GDSC1 1.9807 3.7707 -0.5997 0.8581
LOX-IMVI GDSC1 1.9856 3.5309 -0.5081 0.5073
COLO 829 GDSC1 2.0135 5.1981 -1.1749 4.0141
SK-MEL-3 GDSC1 2.0406 3.4831 -0.4696 0.3588
WM278 GDSC1 2.0491 8.724 -2.795 14.2695
A-375 GDSC1 2.0613 3.8428 -0.5933 0.7674
MeWo GDSC1 2.0969 3.8428 -0.5787 0.6853
SK-MEL-5 GDSC1 2.1939 3.5471 -0.4356 0.2154
COLO 679 GDSC1 2.2247 3.7242 -0.486 0.3214
COLO 800 GDSC1 2.2424 4.5175 -0.7754 1.4044
DJM-1 GDSC1 2.2457 4.2 -0.6514 0.8562
COLO 792 GDSC1 2.2465 4.0799 -0.6062 0.6834
G-mel GDSC1 2.247 3.9528 -0.5593 0.5225
A-431 GDSC1 2.2603 4.1456 -0.625 0.7434
CHL-1 GDSC1 2.2664 4.0274 -0.5789 0.5757
451Lu GDSC1 2.3258 3.984 -0.5402 0.4231
G-361 GDSC1 2.3293 3.689 -0.4361 0.1773
Hs 940.T GDSC1 2.3609 4.0343 -0.5449 0.4195
HMV-II GDSC1 2.4119 4.8115 -0.8154 1.4219
WM793 GDSC1 2.4633 4.9148 -0.8331 1.4535
Mel JuSo GDSC1 2.492 4.345 -0.6062 0.5351
IST-MEL1 GDSC1 2.675 5.0502 -0.7939 1.0918
SK-MEL-24 GDSC1 2.7618 4.4537 -0.5443 0.2628
SH-4 GDSC1 2.7971 6.3325 -1.2509 3.233
A-388 GDSC1 2.9523 4.9337 -0.642 0.4188
WM35 GDSC1 3.1156 5.3693 -0.7353 0.6003
EquiPSC Line K2 GDSC1 1.6454 4.6104 -1.1213 4.3529
⏷ Show the Full List of 54 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1 2.638 4.1911 -0.4984 0.2091
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Rh30 GDSC1 1.0045 4.7842 -1.6155 9.416
MES-SA GDSC1 1.531 2.6528 -0.3665 0.3105
SW684 GDSC1 1.6147 2.7332 -0.3634 0.2613
SW872 GDSC1 1.8648 3.4448 -0.5248 0.6481
Rh18 GDSC1 1.932 3.3715 -0.4711 0.4183
HT-1080 GDSC1 1.9344 4.9082 -1.0912 3.6211
EW-8 GDSC1 1.9901 3.6712 -0.5582 0.6844
SK-UT-1 GDSC1 2.0278 4.2398 -0.7628 1.5752
SW982 GDSC1 2.0357 3.6011 -0.514 0.4972
Rh41 GDSC1 2.0369 3.6804 -0.5426 0.5946
VA-ES-BJ GDSC1 2.0757 3.5664 -0.486 0.3888
RKN GDSC1 2.0978 3.3169 -0.3909 0.1563
Hs 633.T GDSC1 2.2693 3.6985 -0.4607 0.2446
GCT GDSC1 2.3549 4.0453 -0.551 0.4401
KYM-1 GDSC1 2.3835 3.8928 -0.4868 0.2632
MFH-ino GDSC1 2.6572 4.4597 -0.5846 0.3944
SK-LMS-1 GDSC1 2.9053 4.7903 -0.609 0.3567
STS-0421 GDSC1 2.9445 5.2656 -0.7643 0.7888
G-401 GDSC1 3.1333 5.37 -0.7288 0.5726
A-204 GDSC1 3.1653 5.6808 -0.829 0.8733
RD GDSC1 3.2997 5.1142 -0.58 0.1882
G-402 GDSC1 3.7428 5.7757 -0.6494 0.2007
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SCH GDSC1 0.644 2.4831 -0.7545 3.9822
MKN45 GDSC1 0.9881 4.0872 -1.2903 7.0751
SNU-16 GDSC1 1.0946 2.935 -0.6869 2.5077
23132/87 GDSC1 1.2219 2.935 -0.6178 1.8469
NUGC-4 GDSC1 1.4419 4.1399 -1.0276 4.1263
HGC-27 GDSC1 1.5416 3.7478 -0.7987 2.4472
SNU-1 GDSC1 1.572 3.7596 -0.7878 2.3322
SNU-5 GDSC1 1.6062 3.454 -0.643 1.4514
MKN1 GDSC1 1.8128 3.3254 -0.5015 0.5971
KATO III GDSC1 1.8368 4.9857 -1.1797 4.3699
ECC10 GDSC1 1.9599 5.5524 -1.363 5.3411
OCUM-1 GDSC1 2.0948 4.1056 -0.6796 1.1042
TMK-1 GDSC1 2.1128 3.713 -0.5246 0.4871
NCI-N87 GDSC1 2.2385 4.3696 -0.7194 1.1493
RF-48 GDSC1 2.2415 4.2835 -0.6849 0.9972
HSC-39 GDSC1 2.2652 3.6514 -0.4459 0.2146
Fu97 GDSC1 2.2923 4.1039 -0.5967 0.6202
NUGC-3 GDSC1 2.4094 4.0901 -0.5464 0.4011
TGBC11TKB GDSC1 2.4753 4.5303 -0.6808 0.8004
Hs 746.T GDSC1 2.512 4.4054 -0.6203 0.5684
MKN7 GDSC1 2.5259 4.381 -0.6061 0.5169
SK-GT-2 GDSC1 2.9179 5.4819 -0.8557 1.1488
RERF-GC-1B GDSC1 2.9768 5.503 -0.8393 1.0395
SNG-M GDSC1 2.2416 3.6545 -0.4555 0.2425
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CGTH-W-1 GDSC1 1.0569 3.2088 -0.8326 3.5805
TT GDSC1 1.258 3.8243 -0.9933 4.274
BHT-101 GDSC1 1.3464 4.4157 -1.2121 5.6205
8505C GDSC1 1.5216 5.2544 -1.4932 7.1933
CAL-62 GDSC1 1.5609 3.5183 -0.6916 1.7805
WRO GDSC1 1.8202 3.6557 -0.625 1.1193
ASH-3 GDSC1 1.8575 3.1923 -0.4352 0.3487
IHH-4 GDSC1 2.0019 3.3676 -0.4431 0.3042
K5 GDSC1 2.0437 4.2737 -0.7691 1.5891
B-CPAP GDSC1 2.0665 3.874 -0.6029 0.8019
KMH-2 GDSC1 2.0754 3.6065 -0.5005 0.4321
FTC-133 GDSC1 2.1262 3.6037 -0.4802 0.3486
TT2609-C02 GDSC1 2.2682 4.3382 -0.6945 1.0149
8305C GDSC1 2.3536 3.8801 -0.4932 0.2886
ML-1 [Human leukemia] GDSC1 2.4691 3.9344 -0.4704 0.2031
HTC-C3 GDSC1 2.8787 4.8543 -0.6414 0.4484
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 38 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HSC-2 GDSC1 0.7048 2.594 -0.7671 3.9227
CAL-27 GDSC1 1.1868 10.4807 -4.2871 24.0435
KOSC-2 GDSC1 1.2543 3.7287 -0.9517 3.9927
OSC-19 GDSC1 1.3503 3.3484 -0.7279 2.3207
PCI-15A GDSC1 1.3678 3.5443 -0.8039 2.7757
BICR 22 GDSC1 1.513 3.0315 -0.5167 0.9172
OSC-20 GDSC1 1.515 4.0251 -0.9343 3.359
HSC-3 GDSC1 1.5873 10.1848 -3.8376 20.9332
BB49-HNC GDSC1 1.7068 4.6063 -1.0843 3.9886
KON GDSC1 1.7457 3.4042 -0.5597 0.8906
Detroit 562 GDSC1 1.7975 3.8041 -0.6947 1.4926
SCC-4 GDSC1 1.8103 3.5396 -0.584 0.9397
SCC-9 GDSC1 1.8482 5.8575 -1.5693 6.9633
SCC-25 GDSC1 1.949 3.8579 -0.6471 1.095
HSC-4 GDSC1 1.9816 3.5466 -0.5154 0.5347
PCI-30 GDSC1 2.0909 5.1322 -1.1043 3.4397
CAL-33 GDSC1 2.1047 3.7685 -0.548 0.57
DOK GDSC1 2.1259 4.4653 -0.8079 1.6936
BICR 10 GDSC1 2.224 4.3556 -0.7202 1.1667
SCC-15 GDSC1 2.249 6.1385 -1.4595 5.4066
BB30-HNC GDSC1 2.2592 3.9255 -0.5447 0.4701
BICR 78 GDSC1 2.3189 4.5182 -0.7419 1.1759
JHU-022 GDSC1 2.3313 4.5802 -0.7606 1.248
HO-1-N-1 GDSC1 2.3524 4.5416 -0.7365 1.1222
HO-1-u-1 GDSC1 2.3606 4.3707 -0.6681 0.8349
UPCI-SCC-090 GDSC1 2.3687 4.6886 -0.7864 1.3301
PE/CA-PJ15 GDSC1 2.3767 4.3013 -0.6357 0.7028
Ca9-22 GDSC1 2.4382 4.3709 -0.6368 0.667
LB771-HNC GDSC1 2.4388 4.9385 -0.8534 1.5748
PCI-04B GDSC1 2.465 4.6204 -0.7189 0.9552
BHY GDSC1 2.5008 4.3139 -0.5917 0.4865
PCI-38 GDSC1 2.529 4.3466 -0.5926 0.4751
SAT [Human HNSCC] GDSC1 2.5398 5.7205 -1.1235 2.8749
JHU-029 GDSC1 2.614 5.7628 -1.1045 2.6688
SKN-3 GDSC1 2.6517 5.2433 -0.8783 1.4783
SAS GDSC1 2.741 4.5713 -0.5928 0.3807
PCI-06A GDSC1 2.7516 4.6718 -0.6243 0.4589
NCI-H3118 GDSC1 2.904 5.1704 -0.7454 0.7494
⏷ Show the Full List of 38 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW780 GDSC1 1.2172 10.492 -4.2694 23.8809
KU-19-19 GDSC1 1.3392 2.6219 -0.4334 0.7012
639V GDSC1 1.5899 2.6302 -0.3364 0.2025
BFTC-905 GDSC1 1.6971 3.2167 -0.5085 0.7129
RT-112 GDSC1 1.8226 3.409 -0.5288 0.6954
CAL-29 GDSC1 1.9157 3.4609 -0.5102 0.5587
HT-1197 GDSC1 2.067 3.8474 -0.5927 0.7607
647V GDSC1 2.2168 3.4772 -0.4036 0.1488
SW1710 GDSC1 2.3224 4.4839 -0.7272 1.1081
TCCSUP GDSC1 2.3363 4.1467 -0.595 0.5874
HT-1376 GDSC1 2.3506 4.6222 -0.7685 1.2655
T24 GDSC1 2.4018 4.2758 -0.6164 0.6197
RT-4 GDSC1 2.4215 4.4377 -0.6682 0.7913
J82 GDSC1 2.5436 4.5172 -0.6487 0.6427
UM-UC-3 GDSC1 2.6326 4.1473 -0.4853 0.1871
5637 GDSC1 3.0852 5.1415 -0.6659 0.4251
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 35 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SKG-IIIa GDSC1 1.3579 4.1612 -1.0874 4.7164
HeLa GDSC1 1.4533 2.7203 -0.4224 0.5576
NT2-D1 GDSC1 1.5818 3.2749 -0.5821 1.1635
TC-YIK GDSC1 1.597 5.6601 -1.6355 8.0032
OVCA433 GDSC1 1.6752 4.1224 -0.8893 2.7913
HT-3 GDSC1 1.9074 3.9718 -0.711 1.449
SKN GDSC1 1.9105 4.4799 -0.9194 2.6032
SiHa GDSC1 1.9375 3.2151 -0.4133 0.2551
OVCA420 GDSC1 2.0495 4.1012 -0.6978 1.2322
DoTc2 4510 GDSC1 2.0695 3.7978 -0.573 0.6836
SW962 GDSC1 2.0866 5.44 -1.2409 4.3046
MS751 GDSC1 2.1026 3.514 -0.4573 0.2985
JEG-3 GDSC1 2.1061 3.5028 -0.4521 0.2841
SW954 GDSC1 2.1559 4.4127 -0.773 1.484
OMC-1 [Human cervical carcinoma] GDSC1 2.234 4.2649 -0.681 0.9871
HEC-1 GDSC1 2.2715 3.8572 -0.5156 0.3794
ACC-OV7 GDSC1 2.278 11.4819 -3.971 19.6499
SW756 GDSC1 2.2856 4.1452 -0.6146 0.6876
JAR GDSC1 2.3007 4.1499 -0.6103 0.6623
C-33 A GDSC1 2.317 4.3214 -0.6676 0.8656
LB831-BLC GDSC1 2.3955 4.2451 -0.6076 0.594
CAL-39 GDSC1 2.4372 4.7084 -0.7643 1.1678
Ca Ski GDSC1 2.5026 4.6991 -0.733 0.9822
PWR-1E GDSC1 2.5143 4.4957 -0.6524 0.6731
UWB1.289 GDSC1 2.5222 4.78 -0.7555 1.0581
DSH1 GDSC1 2.5903 4.3656 -0.5762 0.4011
PEO1 GDSC1 2.6106 4.8902 -0.7602 1.0069
KGN GDSC1 2.6515 4.7902 -0.7061 0.7729
ME-180 GDSC1 2.6893 5.7133 -1.0482 2.2724
SiSo GDSC1 2.865 4.9718 -0.6885 0.5891
HEY GDSC1 2.8947 5.0891 -0.7194 0.6694
OV17R GDSC1 3.122 5.2914 -0.7051 0.5116
JHOS-3 GDSC1 3.1804 5.3236 -0.6946 0.4589
BPH-1 GDSC1 3.2834 6.0574 -0.9211 1.1277
OVMIU GDSC1 3.3775 5.755 -0.7736 0.5832
⏷ Show the Full List of 35 Cancer Drug Sensitivity Data of This Drug

References

1 Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain. Nat Chem Biol. 2013 Mar;9(3):184-91.
2 Methyllysine reader plant homeodomain (PHD) finger protein 20-like 1 (PHF20L1) antagonizes DNA (cytosine-5) methyltransferase 1 (DNMT1) proteasomal degradation. J Biol Chem. 2014 Mar 21;289(12):8277-87. doi: 10.1074/jbc.M113.525279. Epub 2014 Feb 3.
3 PHF20L1 antagonizes SOX2 proteolysis triggered by the MLL1/WDR5 complexes. Lab Invest. 2018 Dec;98(12):1627-1641. doi: 10.1038/s41374-018-0106-8. Epub 2018 Aug 8.