Details of the Drug

General Information of Drug (ID: DMWO5ZR)

Drug Name
Cediranib
Synonyms
Recentin; AZD 2171; AZD2171; M6294; AZD-2171; ZD-2171; AZD2171, Recentin, Cediranib; Cediranib (USAN/INN); 4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazoline; 4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-[3-(pyrrolidin-1-yl)propoxy]quinazoline
Indication
Disease Entry ICD 11 Status REF
Peritoneal cavity cancer 2C51.Z Phase 3 [1]
Therapeutic Class
Anticancer Agents
Affected Organisms
Humans and other mammals
ATC Code
L01EK02: Cediranib
L01EK: Vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitors
L01E: PROTEIN KINASE INHIBITORS
L01: ANTINEOPLASTIC AGENTS
L: ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 450.5
Logarithm of the Partition Coefficient (xlogp) 4.9
Rotatable Bond Count (rotbonds) 8
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 7
ADMET Property
Absorption
The drug is orally available []
Half-life
The concentration or amount of drug in body reduced by one-half in 12 - 35 hours [2]
Chemical Identifiers
Formula
C25H27FN4O3
IUPAC Name
4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazoline
Canonical SMILES
CC1=CC2=C(N1)C=CC(=C2F)OC3=NC=NC4=CC(=C(C=C43)OC)OCCCN5CCCC5
InChI
InChI=1S/C25H27FN4O3/c1-16-12-17-19(29-16)6-7-21(24(17)26)33-25-18-13-22(31-2)23(14-20(18)27-15-28-25)32-11-5-10-30-8-3-4-9-30/h6-7,12-15,29H,3-5,8-11H2,1-2H3
InChIKey
XXJWYDDUDKYVKI-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
9933475
ChEBI ID
CHEBI:94782
CAS Number
288383-20-0
UNII
NQU9IPY4K9
DrugBank ID
DB04849
TTD ID
D09VMI
INTEDE ID
DR1886
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Vascular endothelial growth factor receptor 2 (KDR) TTUTJGQ VGFR2_HUMAN Inhibitor [3]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4)
Main DME 		DE4LYSA CP3A4_HUMAN Substrate [4]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Peritoneal cavity cancer
ICD Disease Classification 2C51.Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Vascular endothelial growth factor receptor 2 (KDR) DTT KDR 1.98E-01 0.11 0.2
Cytochrome P450 3A4 (CYP3A4) DME CYP3A4 1.04E-02 6.29E-02 3.54E-01
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 44 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC2 2.1507 3.5063 1.989 12.6178
HuO9 GDSC2 0.1349 5.6867 -0.9993 36.6293
G-292 clone A141B1 GDSC2; CTRP2 0.4589 3.4745 0.4128 37.3566
CHSA0011 GDSC2 0.5334 3.7618 0.1482 29.931
NOS-1 [Human HNSCC] GDSC2 0.907 4.8248 0.1648 28.0854
CHSA8926 GDSC2 0.9385 4.6377 0.2722 27.4037
CAL-72 GDSC2 1.4453 3.523 1.2157 20.0524
ES1 GDSC2 1.4533 4.0181 1.0577 20.8931
EW-1 GDSC2 1.7114 4.9613 0.9501 20.4155
U2OS GDSC2 1.8938 6.4365 0.4583 22.4286
NY GDSC2 1.9349 4.5289 1.367 17.0993
SJSA-1 GDSC2 2.0027 3.7291 1.7535 14.5876
ES6 GDSC2 2.0432 4.0894 1.6615 14.9415
EW-7 GDSC2 2.0493 4.0864 1.6692 14.8715
H-EMC-SS GDSC2 2.0753 9.6198 -0.918 28.0858
EW-11 GDSC2 2.1356 3.6722 1.9172 13.0861
Hs 822.T CTRP2 2.1707 2.9563 2.1707 25.8068
EW-22 GDSC2 2.2159 3.493 2.0642 11.9102
EW-12 GDSC2 2.2674 3.4971 2.1189 11.3765
SK-N-MC CTRP2 2.2979 2.9273 2.2979 24.96
Hs 888.T CTRP2 2.3442 3.8025 2.3392 24.6681
A-673 GDSC2; CTRP2 2.3649 3.3388 2.3647 24.514
SK-PN-DW GDSC2 2.4146 3.4601 2.2908 9.7664
HuO-3N1 GDSC2 2.4178 4.445 1.9011 12.0231
EW-3 GDSC2 2.4334 3.5764 2.2725 9.786
SK-ES-1 GDSC2; CTRP2 2.4772 3.4602 2.4769 23.766
ES7 GDSC2 2.4817 3.7117 2.2753 9.5619
ES5 GDSC2 2.4841 3.7239 2.2733 9.5634
CAL-78 GDSC2 2.5004 4.6527 1.8901 11.7751
U-CH2 GDSC2 2.5335 5.0887 1.7186 12.6986
SaOS-2 GDSC2; CTRP2 2.5608 3.8025 2.5584 23.2161
EW-13 GDSC2 2.5734 4.1962 2.1703 9.8067
EW-18 GDSC2 2.609 3.4978 2.4897 7.797
EW-16 GDSC2 2.6234 4.2645 2.1907 9.491
ES8 GDSC2 2.6446 3.469 2.5379 7.3701
MG-63 GDSC2; CTRP2 2.6707 6.6111 2.1936 24.1527
CADO-ES1 GDSC2 2.6817 3.6487 2.513 7.3517
EW-24 GDSC2 2.6824 3.2615 2.6395 6.6418
MHH-ES-1 GDSC2 3.1043 5.0395 2.2756 7.2858
CHSA0108 GDSC2 3.287 11.64 -0.8662 23.9171
TC71 CTRP2 3.5353 4.8741 3.5158 16.7814
HOS GDSC2; CTRP2 3.6846 6.134 3.444 16.5659
TC-71 GDSC2 3.8623 5.6481 2.5726 3.3845
ES4 GDSC2 4.8513 9.3207 1.4814 7.8135
⏷ Show the Full List of 44 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 192 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MEC1 CTRP2 2.337 3.8421 2.3309 24.7194
JM1 GDSC2; CTRP2 2.3315 3.5984 2.3297 24.7416
EoL-1 GDSC2; CTRP2 -9.1517 -7.654 -9.1517 97.4296
Kasumi-1 GDSC2; CTRP2 -3.4079 1.0831 -3.4476 62.2361
OPM-2 GDSC2; CTRP2 -1.5977 2.4518 -1.6551 50.8824
CTV-1 GDSC2 -0.0412 1.2879 -0.0458 33.7721
KMS-11 GDSC2 0.289 5.0927 -0.5968 34.4251
SU-DHL-5 GDSC2 0.4291 1.2904 0.4286 29.0322
BL-41 GDSC2 0.5524 1.6484 0.5486 27.8116
WSU-DLCL2 GDSC2 0.6544 1.4787 0.6538 26.7718
WSU-NHL GDSC2 0.6697 2.9725 0.5149 27.4108
CML-T1 GDSC2 0.697 1.8422 0.6902 26.3755
GR-ST GDSC2 0.7961 2.056 0.7823 25.4164
Ku812 GDSC2 0.8034 2.9287 0.6699 25.9619
BE-13 GDSC2 0.8782 2.0038 0.8696 24.5666
GDM-1 GDSC2 0.8807 3.4719 0.6154 25.8838
Mono-Mac-6 GDSC2 0.9488 2.6351 0.8821 24.1559
HT GDSC2 0.9956 5.2299 0.0922 28.0402
DEL GDSC2 1.0834 3.0442 0.9488 23.1627
RPMI-8402 GDSC2 1.0925 2.3617 1.0687 22.4934
Farage GDSC2 1.2893 2.3596 1.2745 20.4726
LAMA-84 GDSC2 1.3796 3.0976 1.259 20.1197
MLMA GDSC2 1.4231 3.6544 1.1503 20.5119
TALL-1 [Human adult T-ALL] GDSC2 1.4492 2.9202 1.3722 19.1902
SUP-B8 GDSC2 1.4786 3.2389 1.3323 19.2655
EB1 CTRP2 1.5079 4.3144 1.4366 30.4614
ALL-SIL GDSC2 1.6009 3.3737 1.4293 18.1769
SU-DHL-10 GDSC2 1.6951 2.8654 1.6471 16.5721
H9 GDSC2 1.7001 4.1939 1.2558 18.7139
MEG-01 GDSC2 1.7076 3.298 1.5666 16.9418
Jiyoye GDSC2 1.7635 3.3553 1.6119 16.4393
Namalwa GDSC2; CTRP2 1.7781 2.9689 1.7777 28.4237
Loucy GDSC2 1.7793 3.7866 1.492 17.0337
A4/Fukuda GDSC2; CTRP2 1.785 2.8843 1.7848 28.3772
IM-9 GDSC2 1.7888 3.1315 1.6966 15.8653
SU-DHL-16 GDSC2 1.8068 3.5623 1.597 16.3259
JVM-3 GDSC2 1.82 3.8575 1.5107 16.7519
Karpas-45 GDSC2 1.822 3.488 1.6368 16.0374
BV-173 GDSC2 1.8228 3.4935 1.636 16.0383
U-698-M GDSC2 1.8371 3.4244 1.6724 15.7741
P12-Ichikawa GDSC2 1.8704 3.2525 1.7562 15.1654
EB2 GDSC2 1.9019 4.0346 1.5325 16.2775
MOLT-4 GDSC2 1.9165 4.1617 1.4985 16.4114
Daudi GDSC2; CTRP2 1.9222 3.1748 1.9214 27.4656
BC-1 GDSC2 1.9609 3.3457 1.8301 14.3481
MV4-11 GDSC2 1.961 4.8205 1.2683 17.5726
JVM-2 GDSC2 1.9755 5.1501 1.1362 18.289
KE-37 GDSC2 1.9866 3.0852 1.9218 13.7361
Karpas-1106P GDSC2 1.9989 3.6323 1.7829 14.4389
SU-DHL-6 GDSC2 2.0094 3.3429 1.8837 13.8344
NALM-6 GDSC2 2.0196 4.1918 1.5955 15.4216
Pfeiffer CTRP2 2.058 3.721 2.0502 26.584
P32/ISH GDSC2 2.0622 3.4779 1.9016 13.4973
KG-1 GDSC2 2.0759 9.3899 -0.8041 27.6385
MOLM-13 GDSC2 2.0905 3.6582 1.8732 13.5301
GA-10 GDSC2; CTRP2 2.0916 3.0873 2.0914 26.3349
CTB-1 GDSC2 2.1087 3.394 1.9775 12.8702
MOLT-13 GDSC2 2.1136 3.2724 2.0165 12.6352
SR GDSC2 2.1223 3.462 1.972 12.8392
MY-M12 GDSC2 2.1268 3.3475 2.0106 12.6067
HuNS1 CTRP2 2.137 4.0836 2.1157 26.1029
MN-60 GDSC2 2.1465 3.9908 1.8101 13.6511
OCI-Ly7 GDSC2 2.1485 3.2609 2.0574 12.253
Mino CTRP2 2.1617 3.3947 2.1606 25.8706
SUP-T1 GDSC2 2.1758 3.6231 1.9776 12.5707
MC116 GDSC2 2.186 3.1694 2.1204 11.7404
VAL GDSC2 2.1868 3.7283 1.9525 12.6643
Karpas-299 GDSC2 2.1876 3.8667 1.9019 12.95
697 GDSC2; CTRP2 2.1996 3.3453 2.1989 25.6169
HAL-01 GDSC2 2.2094 3.3711 2.0941 11.7743
U266B1 GDSC2; CTRP2 2.21 3.355 2.2094 25.5473
Karpas-620 GDSC2 2.2298 3.2323 2.1533 11.3591
K-562 GDSC2; CTRP2 2.2462 3.2261 2.246 25.3046
Toledo CTRP2 2.2476 4.1362 2.2271 25.3638
JeKo-1 GDSC2; CTRP2 2.2595 3.1975 2.2594 25.2158
MOTN-1 CTRP2 2.2612 3.3021 2.2609 25.205
MOLT-3 CTRP2 2.266 3.0251 2.266 25.1722
L-1236 GDSC2 2.267 3.6278 2.0747 11.626
L-540 GDSC2 2.2925 3.4505 2.161 11.0313
CRO-AP2 GDSC2 2.299 3.5503 2.1358 11.1424
CA46 GDSC2; CTRP2 2.3387 3.2611 2.3386 24.6881
Raji GDSC2 2.3466 3.3801 2.2411 10.3462
Jurkat GDSC2 2.3565 3.1939 2.3004 9.9801
NCI-H929 GDSC2 2.3588 3.3075 2.2747 10.1078
Hs 611.T CTRP2 2.3645 3.8642 2.3583 24.5365
BALL-1 GDSC2 2.3906 3.3058 2.3098 9.771
EM-2 GDSC2 2.3929 3.3055 2.3125 9.7459
Karpas-422 GDSC2; CTRP2 2.4013 3.0531 2.4013 24.2709
RCH-ACV GDSC2 2.4058 3.6306 2.2236 10.1818
Granta-519 GDSC2; CTRP2 2.4061 4.2583 2.3839 24.3133
HuT 78 CTRP2 2.4067 3.4312 2.4064 24.2358
NU-DUL-1 GDSC2 2.4165 3.3712 2.3199 9.5977
PF-382 GDSC2 2.4228 3.4588 2.3001 9.6783
TUR GDSC2 2.4232 3.3103 2.3443 9.4338
CCRF-CEM GDSC2 2.4324 3.4345 2.3182 9.5351
DND-41 GDSC2; CTRP2 2.4361 3.2424 2.4361 24.0389
KMS-12-BM GDSC2 2.4363 4.2631 2.0004 11.358
DB GDSC2; CTRP2 2.4474 3.5512 2.4466 23.9665
HC-1 GDSC2 2.4494 4.9768 1.6891 13.1855
NK-92MI GDSC2 2.4638 3.5168 2.3258 9.3539
THP-1 GDSC2 2.4652 3.4146 2.3601 9.1571
BC-3 GDSC2 2.4657 3.4971 2.3344 9.2974
Kasumi-2 CTRP2 2.4687 2.9491 2.4687 23.8219
KOPN-8 GDSC2 2.4804 3.6256 2.3058 9.3941
LC4-1 GDSC2 2.4805 3.5166 2.3439 9.1786
NU-DHL-1 CTRP2 2.4815 3.4047 2.4813 23.7372
KMS-20 CTRP2 2.4846 3.0636 2.4846 23.7156
NB4 GDSC2 2.4907 3.3691 2.4015 8.8139
Reh GDSC2 2.4926 3.3705 2.4031 8.7964
WIL2 NS GDSC2 2.4959 3.5674 2.3432 9.1152
KMOE-2 GDSC2 2.4983 3.4742 2.3773 8.9137
ST486 GDSC2; CTRP2 2.513 3.2187 2.513 23.5269
ARH-77 GDSC2 2.5137 3.5252 2.3771 8.8469
SUP-M2 GDSC2; CTRP2 2.5231 3.092 2.5231 23.4592
SU-DHL-4 GDSC2 2.5234 3.4629 2.4083 8.6296
RPMI-6666 GDSC2; CTRP2 2.5256 4.1305 2.5139 23.4818
MOLP-8 GDSC2; CTRP2 2.528 3.1477 2.528 23.4268
AMO1 GDSC2 2.5307 3.429 2.427 8.4929
M-07e CTRP2 2.5312 3.0478 2.5312 23.4057
L-428 GDSC2; CTRP2 2.5329 3.5268 2.5325 23.3955
F-36P CTRP2 2.5338 3.312 2.5337 23.3885
P30/OHK GDSC2 2.5346 3.3775 2.4468 8.3666
ML-2 GDSC2 2.5357 3.3216 2.464 8.268
NKM-1 GDSC2 2.5408 3.4788 2.4219 8.4767
AML-193 CTRP2 2.5578 2.9998 2.5578 23.2279
RL GDSC2; CTRP2 2.5583 3.2824 2.5583 23.2251
SEM CTRP2 2.5711 3.0634 2.5711 23.1393
MHH-CALL-4 GDSC2 2.5731 3.4798 2.4567 8.1395
SKM-1 GDSC2 2.5743 3.3066 2.5102 7.8393
OCI-AML-2 GDSC2 2.5773 3.5917 2.4225 8.314
OCI-AML-3 GDSC2; CTRP2 2.5843 3.5628 2.5839 23.0532
NOMO-1 GDSC2 2.5868 3.5056 2.463 8.0443
YT GDSC2 2.5873 3.232 2.5428 7.6036
A3/Kawakami GDSC2; CTRP2 2.5968 3.0151 2.5968 22.9684
SET-2 CTRP2 2.6052 3.0001 2.6052 22.9125
Ramos.2G6.4C10 GDSC2 2.6071 3.3868 2.5231 7.6196
OCI-AML-5 CTRP2 2.6143 2.9886 2.6143 22.8515
KO52 CTRP2 2.6156 2.9775 2.6156 22.8428
KCL-22 GDSC2 2.6228 3.8776 2.3587 8.493
JJN-3 GDSC2; CTRP2 2.6262 3.1603 2.6262 22.7723
ALL-PO GDSC2 2.6296 3.8952 2.3584 8.4672
BONNA-12 GDSC2 2.6358 5.0102 1.8548 11.4952
HH [Human lymphoma] GDSC2; CTRP2 2.6399 3.7324 2.6389 22.6847
JSC-1 GDSC2 2.6402 3.926 2.3565 8.4354
KY821 GDSC2 2.6519 3.4053 2.5663 7.1802
P31/FUJ GDSC2 2.6528 3.3115 2.5945 7.0219
MOLT-16 GDSC2 2.6567 3.324 2.5954 6.9989
ROS-50 GDSC2 2.6686 5.2255 1.7828 11.8228
CESS GDSC2 2.6703 3.6796 2.4889 7.5387
SIG-M5 GDSC2; CTRP2 2.675 3.4269 2.675 22.4474
MHH-PREB-1 GDSC2 2.6884 3.515 2.5696 7.0006
DG-75 GDSC2 2.7116 3.6918 2.528 7.1404
OCI-Ly19 GDSC2; CTRP2 2.7148 4.7436 2.666 22.3468
DoHH2 GDSC2 2.7479 3.5076 2.6365 6.3645
Ci-1 CTRP2 2.7613 3.2217 2.7613 21.8724
RC-K8 GDSC2 2.7637 3.5765 2.6282 6.3438
SCC-3 GDSC2 2.7652 3.454 2.6737 6.0792
OCI-Ly10 CTRP2 2.7715 4.4957 2.7476 21.8847
ATN-1 GDSC2 2.7728 3.5853 2.6346 6.2686
RPMI-8226 GDSC2 2.773 3.6712 2.6012 6.4603
HEL GDSC2 2.7797 3.5324 2.6619 6.083
BL-70 CTRP2 2.7889 3.3553 2.7889 21.6883
SU-DHL-8 GDSC2 2.8619 3.8096 2.636 5.8965
HDLM-2 GDSC2 2.88 4.4756 2.3452 7.6012
L-363 GDSC2 2.8827 4.4258 2.3717 7.4283
BCP-1 CTRP2 2.9243 4.2803 2.9165 20.8125
LP-1 GDSC2; CTRP2 2.9459 4.0602 2.9436 20.6501
SUP-B15 GDSC2; CTRP2 2.9756 4.0701 2.9735 20.4515
Hs 445 GDSC2 3.0108 4.102 2.6498 5.2557
OCI-Ly3 CTRP2 3.1591 4.6788 3.1381 19.293
MM1.S GDSC2 3.1842 5.0601 2.3355 6.6574
HL-60 GDSC2; CTRP2 3.1967 4.5487 3.1848 19.0118
EJM GDSC2; CTRP2 3.2007 4.4299 3.1938 18.9679
RS4;11 GDSC2 3.2119 4.6823 2.548 5.2296
ME1 GDSC2 3.2289 4.5188 2.6443 4.5685
HD-MY-Z CTRP2 3.2514 4.0776 3.2509 18.609
SU-DHL-1 GDSC2 3.2615 7.4702 1.1972 13.5207
HEL 92.1.7 CTRP2 3.3594 4.047 3.3593 17.8882
MJ CTRP2 3.3706 5.2204 3.3031 18.0425
VL51 GDSC2 3.3798 5.5242 2.2686 6.5023
TF-1 CTRP2 3.3845 4.4203 3.3811 17.732
MHH-CALL-2 GDSC2 3.3892 4.7831 2.6466 4.0841
CMK CTRP2 3.4141 3.9889 3.4141 17.5234
SUP-HD1 GDSC2; CTRP2 3.446 4.8087 3.4275 17.3731
QIMR-WIL GDSC2 3.544 5.747 2.2892 5.9207
KM-H2 GDSC2 3.5791 8.6711 0.8585 14.5844
MOLM-16 GDSC2 3.9282 9.5139 0.7156 14.4258
SK-MM-2 GDSC2 4.2382 7.6131 1.8837 6.7492
OCI-M1 GDSC2; CTRP2 4.2925 5.299 4.2729 11.7374
TK [Human B-cell lymphoma] GDSC2 4.8085 6.6084 2.69 1.2406
Karpas-231 GDSC2 5.1507 6.4655 2.8933 0.2761
PL-21 GDSC2 5.5407 8.5677 2.2358 2.516
⏷ Show the Full List of 192 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE15 CTRP2 2.1191 5.4629 1.9043 26.8847
T.T GDSC2 1.7534 3.3437 1.6041 16.528
TE-1 GDSC2 1.7823 5.2447 0.8979 20.4273
OE21 GDSC2; CTRP2 1.8546 4.18 1.8149 28.0463
TE-11 GDSC2; CTRP2 1.9843 4.6628 1.9001 27.333
KYSE-270 GDSC2 2.0656 4.2159 1.6342 15.0073
TE-6 GDSC2 2.1015 3.6807 1.8773 13.4592
KYSE-180 GDSC2 2.1963 3.5044 2.0392 12.1361
KYSE-140 GDSC2 2.2098 3.9917 1.8769 13.0007
KYSE-410 GDSC2 2.2896 4.5965 1.7031 13.7056
TE-14 CTRP2 2.2982 3.3344 2.2979 24.9589
TE-8 GDSC2 2.3603 6.7641 0.7459 19.1157
TE-5 GDSC2; CTRP2 2.4659 4.1667 2.4508 23.8909
KYSE-150 GDSC2; CTRP2 2.7372 3.5226 2.7372 22.0331
TE-10 GDSC2 2.9345 4.0172 2.6153 5.7443
EC-GI-10 GDSC2; CTRP2 3.2481 6.5252 2.849 20.0446
KYSE-30 CTRP2 3.2909 5.4893 3.1707 18.7565
KYSE-70 GDSC2 3.318 7.5893 1.185 13.4258
TE-9 GDSC2 3.6826 7.2288 1.6603 9.4906
COLO 680N GDSC2 4.1317 7.3391 1.9417 6.6379
OE33 GDSC2; CTRP2 4.3627 9.8337 2.6146 17.9499
KYSE-450 GDSC2; CTRP2 4.3723 7.731 3.5885 14.08
KYSE-520 GDSC2; CTRP2 4.7553 9.6045 3.102 15.0744
TE-4 GDSC2 5.3362 13.3157 -0.112 15.216
KYSE-510 GDSC2; CTRP2 5.3921 8.4823 4.2467 8.917
OE19 GDSC2; CTRP2 6.4505 12.0627 3.3666 10.4552
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 34 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
N2a-PK1 CTRP2 3.206 6.6006 2.7788 20.4269
PaTu 8988s CTRP2 1.7928 4.7893 1.6771 28.715
Hs 766T GDSC2; CTRP2 1.9993 4.3716 1.9495 27.1168
YAPC GDSC2 2.2092 3.4925 2.057 11.9799
BxPC-3 GDSC2 2.2768 3.464 2.1396 11.2196
MIA PaCa-2 GDSC2; CTRP2 2.3109 2.98 2.3109 24.8729
CFPAC-1 GDSC2 2.4319 3.4032 2.3273 9.4875
Panc 02.03 GDSC2; CTRP2 2.4848 3.8765 2.4803 23.7296
PL4 GDSC2 2.5688 3.5684 2.4217 8.3553
Panc 10.05 GDSC2; CTRP2 2.6006 3.8768 2.5976 22.953
KP-3 GDSC2 2.6776 3.9976 2.3644 8.2402
PaTu 8902 GDSC2 2.6911 3.8772 2.4301 7.7966
Panc 03.27 GDSC2; CTRP2 2.9462 4.5225 2.9273 20.7038
HPAC GDSC2 3.111 5.3733 2.1156 8.2731
KP-1N GDSC2 3.1972 4.9204 2.4165 6.106
PaTu 8988t GDSC2; CTRP2 3.2356 4.4837 3.2275 18.7396
SW1990 GDSC2; CTRP2 3.2481 5.2573 3.166 18.9088
KP-4 GDSC2 3.3084 5.0166 2.4633 5.4756
Panc 04.03 GDSC2; CTRP2 3.3604 4.5801 3.3517 17.9101
Panc 08.13 GDSC2; CTRP2 3.3682 5.1012 3.3169 18.0026
HPAF-II GDSC2 3.3976 6.0155 2.0377 7.9111
Capan-2 GDSC2; CTRP2 3.4075 6.0938 3.1531 18.4585
Capan-1 GDSC2; CTRP2 3.4439 5.09 3.3987 17.4776
HuP-T4 GDSC2 3.6724 6.1054 2.2104 6.0813
SU.86.86 GDSC2 3.7353 7.9484 1.3435 11.2894
SUIT-2 GDSC2 3.7683 6.5257 2.0751 6.6844
KP-2 GDSC2; CTRP2 3.8867 5.36 3.835 14.5504
MZ-PC-1 GDSC2 4.0162 7.5856 1.7374 8.1624
PSN1 GDSC2; CTRP2 4.068 5.582 3.9938 13.4209
DAN-G GDSC2; CTRP2 4.0946 5.5013 4.0364 13.1881
HuP-T3 GDSC2; CTRP2 4.2138 6.4056 3.9374 13.1801
AsPC-1 GDSC2; CTRP2 4.3074 7.8571 3.4669 14.7288
PK-45H CTRP2 4.9145 13.9812 1.0991 22.1407
QGP-1 GDSC2 5.5521 17.5616 -2.0356 22.3671
⏷ Show the Full List of 34 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 70 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SH4 CTRP2 2.5374 3.5257 2.537 23.3655
Hs 934.T CTRP2 0.004 3.0586 -0.0316 40.347
HMV-II GDSC2 2.074 3.6355 1.8631 13.6593
Hs 688(A).T CTRP2 2.1825 3.1921 2.1823 25.729
COLO 783 GDSC2 2.184 3.2432 2.1006 11.8559
WM278 GDSC2 2.2022 4.6852 1.5746 14.8125
IST-MEL1 GDSC2 2.2023 3.5612 2.0272 12.176
Hs 938.T GDSC2 2.2508 3.3739 2.1383 11.3444
M14 GDSC2 2.2809 3.581 2.1059 11.3895
VMRC-MELG GDSC2 2.2997 5.4159 1.3361 15.8728
WM793 GDSC2 2.3366 3.2527 2.2647 10.264
SK-MEL-31 GDSC2 2.3406 3.4255 2.221 10.484
Hs 940.T GDSC2; CTRP2 2.3552 4.8531 2.2699 24.8669
COLO 792 GDSC2; CTRP2 2.3632 3.4193 2.3628 24.5261
Hs 895.T CTRP2 2.3781 6.5714 1.8879 26.1295
Hs 839.T CTRP2 2.4342 5.6434 2.2063 24.8365
UACC-257 GDSC2; CTRP2 2.4507 3.3882 2.4505 23.9424
CP50-MEL-B GDSC2 2.4713 4.98 1.7091 12.9834
SK-MEL-3 GDSC2; CTRP2 2.5155 3.2622 2.5155 23.5102
G-mel GDSC2 2.5182 3.7009 2.3185 9.1599
WM1552C GDSC2 2.5206 3.4582 2.4067 8.6509
SK-MEL-24 GDSC2; CTRP2 2.5428 3.3876 2.5427 23.3285
WM35 GDSC2 2.5438 3.4757 2.4263 8.4387
HT-144 GDSC2; CTRP2 2.5483 3.2335 2.5483 23.2913
WM266-4 CTRP2 2.5522 2.922 2.5522 23.2654
IGR-1 GDSC2; CTRP2 2.5767 3.1839 2.5767 23.1024
A101D GDSC2; CTRP2 2.5857 3.3431 2.5857 23.0423
GAK GDSC2 2.5898 3.3639 2.5111 7.7637
RPMI-7951 GDSC2 2.6037 3.5344 2.4713 7.9236
SK-MEL-30 GDSC2 2.6045 5.6953 1.4948 13.8188
IGR-37 GDSC2; CTRP2 2.6048 3.3748 2.6047 22.9154
WM115 GDSC2; CTRP2 2.6094 2.9905 2.6094 22.8845
G-361 GDSC2 2.6125 3.4445 2.5111 7.6618
IPC-298 GDSC2 2.6177 3.4947 2.5002 7.6999
A2058 GDSC2; CTRP2 2.6373 3.0199 2.6373 22.6985
WM983B CTRP2 2.6403 4.0785 2.6331 22.7025
COLO 679 GDSC2 2.6666 3.5651 2.5282 7.3291
A-375 GDSC2 2.7173 4.3171 2.2608 8.7113
Mel Ho GDSC2 2.7182 3.4105 2.637 6.492
COLO 800 GDSC2; CTRP2 2.7489 3.5328 2.7488 21.9556
MeWo GDSC2; CTRP2 2.7619 3.6336 2.7617 21.869
MZ-MEL-2 GDSC2 2.8383 4.4949 2.296 8.0537
DJM-1 GDSC2 2.8639 6.1236 1.5232 12.7697
A-431 GDSC2 2.941 4.6497 2.3189 7.5527
Hs 294T CTRP2 2.9611 3.8192 2.9608 20.5422
SH-4 GDSC2 3.0241 4.713 2.3648 6.9852
CHL-1 GDSC2 3.0287 4.9654 2.2446 7.7239
COLO 829 GDSC2; CTRP2 3.1051 5.1246 3.033 19.8269
UACC-62 GDSC2; CTRP2 3.142 4.3114 3.1374 19.3516
SK-MEL-2 GDSC2; CTRP2 3.1982 4.4911 3.1889 18.9928
IGR-39 CTRP2 3.2739 4.9816 3.2311 18.6022
SK-MEL-28 GDSC2 3.2884 5.1874 2.3611 6.1817
A-388 GDSC2 3.2939 6.3571 1.7809 9.8277
Mel JuSo GDSC2 3.303 4.4508 2.7416 3.7297
CJM [Human melanoma] CTRP2 3.3319 4.8425 3.3058 18.1588
WT2-iPS GDSC2; CTRP2 3.4165 4.5038 3.4116 17.5237
WM88 CTRP2 3.5259 4.9075 3.5034 16.854
RVH-421 GDSC2; CTRP2 3.6576 4.3639 3.6573 15.9022
HMCB CTRP2 3.6885 7.0644 3.1372 17.6928
MZ-MEL-7 GDSC2 3.878 7.2764 1.7868 8.2002
SK-MEL-5 GDSC2 3.9308 6.2315 2.3381 4.6656
K029AX CTRP2 4.5005 7.3745 3.8741 12.6193
LB2518-MEL GDSC2 4.5512 6.187 2.7377 1.311
MMAc-SF GDSC2 4.5632 6.9001 2.4309 2.8922
451Lu GDSC2 4.607 6.8979 2.4574 2.6765
CP66-MEL GDSC2 4.6506 8.3177 1.8256 6.2165
LOX-IMVI GDSC2; CTRP2 5.3605 11.2276 2.8629 14.6714
LB373-MEL-D GDSC2 5.4921 6.7099 2.9322 0.1098
SK-MEL-1 GDSC2 5.4922 6.5367 2.99 0.0494
EquiPSC Line K2 GDSC2 3.3537 7.2293 1.3946 12.0495
⏷ Show the Full List of 70 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OACM5.1 C GDSC2 1.478 6.2557 0.1326 25.7676
KYAE-1 GDSC2 2.2044 3.4887 2.053 12.0233
KYSE-220 GDSC2 2.3231 3.7316 2.0979 11.252
KYSE-50 GDSC2 2.4992 4.1586 2.1106 10.4538
ESO-51 GDSC2 2.7086 3.8319 2.4675 7.5058
OACP4 C GDSC2 2.8895 5.318 1.944 10.0668
FLO-1 GDSC2 2.9725 7.6403 0.8651 16.3728
SK-GT-4 GDSC2 3.4915 9.0522 0.5968 16.3082
ESO-26 GDSC2 3.5287 5.379 2.4602 4.8835
TE-12 GDSC2 4.7902 11.8421 0.2149 14.8916
HCE-4 GDSC2 5.3337 11.3819 0.8201 10.5037
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC2; CTRP2 2.9016 3.8536 2.901 20.9399
Cancer Drug Sensitivity Data Curated from 35 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NB69 GDSC2 -0.061 3.4011 -0.3919 35.4551
SJNB-6 GDSC2 0.0749 2.402 -0.0195 33.0502
NB(TU)1 GDSC2 1.3667 3.4663 1.147 20.7841
Kelly GDSC2 1.6329 3.2863 1.4883 17.7099
SK-N-FI GDSC2; CTRP2 1.6845 4.302 1.6247 29.2469
SJNB-13 GDSC2 1.7705 3.4523 1.5914 16.5196
NH-6 CTRP2 1.9103 3.8653 1.8934 27.5982
GOTO GDSC2 1.9638 4.8593 1.2541 17.6445
SK-N-SH GDSC2; CTRP2 2.0674 3.5123 2.0643 26.5057
CHP-134 GDSC2 2.0934 3.9393 1.7736 14.0846
CHP-126 GDSC2 2.1085 3.3886 1.9789 12.8629
SiMa GDSC2 2.1307 4.0045 1.7879 13.8452
LA-N-6 GDSC2 2.1579 4.6723 1.5352 15.2205
KP-N-YS GDSC2 2.1589 4.6886 1.5289 15.2539
SK-N-DZ GDSC2; CTRP2 2.1682 3.3958 2.1672 25.8271
SJNB-14 GDSC2 2.1767 3.3669 2.0596 12.1116
SJNB-12 GDSC2 2.2111 4.0983 1.8354 13.2368
GI-ME-N GDSC2 2.2345 8.7838 -0.3609 25.1998
SJNB-17 GDSC2 2.2674 3.5416 2.1045 11.457
NB1 GDSC2 2.3111 3.6964 2.0978 11.3042
SK-N-AS GDSC2; CTRP2 2.3643 3.6403 2.3623 24.524
CHP-212 GDSC2; CTRP2 2.4022 3.5369 2.4013 24.2681
SJNB-7 GDSC2 2.4357 4.5532 1.8707 12.1372
SK-N-BE(2) CTRP2 2.4423 3.1506 2.4423 23.9974
NH-12 GDSC2 2.4999 4.3709 2.0176 11.007
IMR-32 CTRP2 2.5149 2.965 2.5149 23.514
SJNB-10 GDSC2 2.5194 3.6828 2.3266 9.1082
MHH-NB-11 GDSC2 2.5596 4.2356 2.1387 10.0495
IMR-5 GDSC2 2.5679 3.3765 2.4835 8.0146
SK-N-MC-IXC GDSC2 2.6043 7.0827 0.8145 17.8754
SK-N-BE(2)-M17 GDSC2 2.7381 4.144 2.3609 8.0261
KP-N-YN GDSC2; CTRP2 2.841 5.1481 2.7461 21.6647
TGW GDSC2 2.8725 4.2003 2.4687 6.8688
SJNB-5 GDSC2 3.9825 8.5357 1.243 11.2396
KP-N-RT-BM-1 GDSC2 4.9218 7.2613 2.4715 2.147
⏷ Show the Full List of 35 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC2 2.0699 3.8023 1.7997 14.0357
SNU-869 CTRP2 2.7422 4.2367 2.7317 22.0349
Cancer Drug Sensitivity Data Curated from 87 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MFM-223 GDSC2 0.6725 6.9186 -0.9787 33.9616
HCC1395 GDSC2 1.0855 4.0709 0.6423 24.8009
Hs 578T GDSC2; CTRP2 1.1239 4.5559 0.9955 33.2012
HCC1806 GDSC2 1.2052 4.7649 0.5041 25.0097
CAL-85-1 GDSC2; CTRP2 2.0471 3.7652 2.0377 26.6621
Evsa-T GDSC2 2.1035 3.2677 2.0066 12.7357
HDQ-P1 GDSC2 2.1662 5.0014 1.3958 16.018
DU4475 GDSC2; CTRP2 2.2167 3.2178 2.2165 25.5015
CAL-51 GDSC2 2.2353 10.39 -1.1541 28.4073
HCC1569 GDSC2 2.2381 4.2236 1.8118 13.2648
CAL-148 GDSC2 2.2776 3.3469 2.1753 11.0198
MDA-MB-157 GDSC2; CTRP2 2.3122 4.3881 2.2766 24.9841
MDA-MB-468 GDSC2; CTRP2 2.3265 3.173 2.3264 24.7694
Hs 578Bst CTRP2 2.3403 3.623 2.3382 24.6843
AU565 GDSC2; CTRP2 2.3451 4.2358 2.322 24.7226
HCC38 GDSC2; CTRP2 2.359 4.7385 2.2892 24.7886
HCC1599 GDSC2 2.468 3.3041 2.3948 8.9541
UACC-812 GDSC2 2.4713 3.6438 2.2894 9.5266
T-47D GDSC2; CTRP2 2.4768 3.5043 2.4764 23.7692
COLO 824 GDSC2 2.4903 3.7639 2.2645 9.5882
MDA-MB-415 GDSC2; CTRP2 2.4992 4.1401 2.4863 23.6617
CAMA-1 GDSC2 2.5167 6.5194 1.0109 17.0351
CAL-120 GDSC2 2.6032 6.2207 1.2372 15.3892
HCC1937 GDSC2 2.636 5.9682 1.3912 14.3425
BT-474 GDSC2; CTRP2 2.6372 3.5268 2.637 22.6998
SK-BR-3 CTRP2 2.6549 3.4053 2.6548 22.5817
HCC2218 GDSC2; CTRP2 2.6666 3.456 2.6665 22.5036
HCC2157 GDSC2 2.7151 3.7017 2.5278 7.1266
MDA-MB-453 GDSC2; CTRP2 2.7255 3.6622 2.7251 22.1124
MDA-MB-361 GDSC2; CTRP2 2.8947 4.8578 2.8436 21.1565
HCC1500 GDSC2; CTRP2 2.9026 4.0112 2.9006 20.9378
YMB-1-E GDSC2 3.0317 4.6067 2.4241 6.5889
MDA-MB-231 GDSC2 3.1533 4.8637 2.4063 6.3069
HCC1428 GDSC2; CTRP2 3.1837 3.9897 3.1834 19.0591
MDA-MB-175-VII GDSC2 3.2239 5.7428 2.0289 8.4739
EFM-192A GDSC2; CTRP2 3.4013 4.311 3.3999 17.6133
UACC-893 GDSC2 3.5285 6.0165 2.1427 6.8854
MDA-MB-330 GDSC2 3.6868 12.8413 -1.1372 23.8254
ZR-75-30 GDSC2; CTRP2 3.7121 4.5406 3.7105 15.5433
BT-483 GDSC2 3.7288 6.6248 1.9961 7.2787
HCC1954 GDSC2 3.7997 6.5985 2.0628 6.6825
HCC1419 GDSC2; CTRP2 3.8122 4.6919 3.8092 14.8814
EFM-19 GDSC2 3.8205 10.4283 0.1752 17.6041
JIMT-1 GDSC2 3.8225 5.4929 2.62 3.1825
OCUB-M GDSC2 3.8708 6.1339 2.343 4.7727
HCC70 GDSC2 4.0213 9.2158 0.9356 12.9347
MCF-7 GDSC2 4.0738 7.5968 1.7741 7.7983
BT-20 GDSC2; CTRP2 4.35 6.2169 4.1454 12.0106
MRK-nu-1 GDSC2 4.5028 6.3804 2.6285 1.9213
HCC1143 GDSC2 4.7503 9.3318 1.4079 8.4528
HCC1187 GDSC2 4.7907 9.3308 1.4359 8.2042
MDA-MB-436 GDSC2 5.2414 9.4092 1.6903 5.8661
HCC202 CTRP2 5.5116 10.2788 3.4683 11.8845
BT-549 GDSC2; CTRP2 5.7482 13.352 2.141 16.6622
BT 440 CTRP2 -0.9409 3.0948 -1.0211 46.6533
BT 231 CTRP2 1.7634 3.6985 1.7499 28.5657
BT 228 CTRP2 1.8202 4.6793 1.7226 28.4711
BT 139 CTRP2 1.8445 3.3905 1.8409 27.992
BT 159 CTRP2 1.8653 2.6483 1.8653 27.8418
BT 482 CTRP2 2.078 3.0918 2.0778 26.4254
BT 271 CTRP2 2.1241 3.775 2.116 26.1446
BT 444 CTRP2 2.1821 3.3698 2.1812 25.7341
BT 286 CTRP2 2.2351 3.0173 2.235 25.3784
BT 239 CTRP2 2.2381 2.9129 2.2381 25.3584
BT 216 CTRP2 2.2914 3.9604 2.2806 25.0388
BT 131 CTRP2 2.3338 2.959 2.3338 24.7204
BT147 CTRP2 2.3369 3.2767 2.3367 24.7005
BT 232 CTRP2 2.3376 3.8699 2.3308 24.7179
BT 330 CTRP2 2.3487 2.931 2.3487 24.6213
BT 112 CTRP2 2.358 2.937 2.358 24.5593
BT 340 CTRP2 2.3664 2.8853 2.3664 24.5037
BT 416 CTRP2 2.3857 3.1071 2.3857 24.3746
BT 172 CTRP2 2.4129 2.989 2.4129 24.1934
BT 428 CTRP2 2.4266 3.0853 2.4266 24.1025
BT164 CTRP2 2.4303 3.7716 2.427 24.0884
BT 245 CTRP2 2.4472 3.1836 2.4472 23.9653
BT 422 CTRP2 2.4948 2.993 2.4948 23.6478
BT 504 CTRP2 2.5321 3.0712 2.5321 23.3993
BT 248 CTRP2 2.5435 3.0986 2.5435 23.3233
BT 359 CTRP2 2.5579 3.1346 2.5579 23.2273
BT 498 CTRP2 2.5796 3.1836 2.5796 23.0831
BT 333 CTRP2 2.7106 3.4039 2.7106 22.2103
BT 145 CTRP2 3.0858 4.0218 3.085 19.7131
BT 179 CTRP2 3.2577 4.931 3.2194 18.6946
BT 328 CTRP2 3.5119 5.5716 3.3939 17.2772
BT 224 CTRP2 4.0657 7.1771 3.4968 15.2655
BT 320 CTRP2 4.3908 6.4946 4.0995 12.0602
⏷ Show the Full List of 87 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 60 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
42-MG-BA GDSC2; CTRP2 0.1065 7.0348 -0.731 41.3832
A-172 GDSC2; CTRP2 0.8265 5.7638 0.4241 35.9721
KG-1-C CTRP2 0.9189 4.2293 0.8217 34.4616
SF539 GDSC2; CTRP2 1.0379 3.5265 1.011 33.443
D-392MG GDSC2 1.0992 3.4006 0.8743 23.488
D-245MG GDSC2 1.1641 3.943 0.7723 23.7453
D-263MG GDSC2 1.2973 4.0111 0.8921 22.4967
MOG-G-CCM GDSC2 1.4033 5.3402 0.4679 24.3522
D283 Med GDSC2; CTRP2 1.4281 3.6575 1.4069 30.8251
DK-MG GDSC2; CTRP2 1.7127 4.4656 1.6362 29.1155
GB-1 GDSC2 1.7613 7.618 -0.2336 26.3824
KS-1 [Human Krukenberg tumour] GDSC2 1.8695 3.6003 1.653 15.7356
YH-13 GDSC2; CTRP2 1.9491 4.439 1.8896 27.484
CAS-1 GDSC2 2.0551 4.5059 1.5017 15.8261
D-542MG GDSC2 2.0766 4.2015 1.6517 14.8601
SW1088 GDSC2 2.0896 3.9753 1.7556 14.2039
U-87MG ATCC GDSC2 2.119 3.5272 1.9479 12.9874
PFSK-1 GDSC2 2.2409 4.3903 1.7437 13.6551
SNB-75 GDSC2; CTRP2 2.2705 4.3944 2.2323 25.2704
M059K CTRP2 2.2852 3.395 2.2846 25.0463
M059J GDSC2 2.3107 4.6265 1.7111 13.5762
KALS-1 GDSC2 2.3176 4.0941 1.949 12.1369
CCF-STTG1 CTRP2 2.3232 4.6073 2.2668 24.9813
T98G GDSC2; CTRP2 2.3464 4.7776 2.2708 24.8927
GaMG GDSC2 2.4385 4.719 1.7978 12.5665
Hs 683 GDSC2; CTRP2 2.439 2.8915 2.439 24.0196
SK-MG-1 GDSC2 2.4453 3.8153 2.1965 10.1692
GOS-3 CTRP2 2.4725 3.6313 2.4713 23.8003
MOG-G-UVW GDSC2 2.4778 3.7177 2.2688 9.616
GI-1 GDSC2 2.478 3.7637 2.2515 9.7144
SF268 GDSC2; CTRP2 2.5012 3.813 2.4981 23.6157
D-423MG GDSC2 2.5405 4.9828 1.7756 12.3246
LN-18 GDSC2 2.5433 3.5646 2.3954 8.6147
GMS-10 CTRP2 2.5615 3.0784 2.5615 23.2037
KINGS-1 GDSC2 2.5727 3.8425 2.3205 8.9212
H4 GDSC2 2.6014 4.0899 2.2458 9.2462
Daoy GDSC2 2.6195 3.5284 2.4904 7.7469
U-251MG GDSC2; CTRP2 2.6757 3.6396 2.6752 22.4444
TM-31 CTRP2 2.7688 3.8933 2.7671 21.8284
KNS-42 GDSC2; CTRP2 2.8307 4.085 2.8266 21.4239
SW1783 GDSC2; CTRP2 2.8344 5.7292 2.622 22.1201
ONS-76 GDSC2 2.8583 4.0082 2.5436 6.4657
AM-38 GDSC2 2.9028 4.0686 2.5601 6.198
D-247MG GDSC2 2.9762 4.6658 2.3439 7.2768
Becker GDSC2; CTRP2 3.0475 4.6683 3.0225 20.0496
U-118MG GDSC2; CTRP2 3.225 4.0324 3.2247 18.7844
YKG-1 GDSC2; CTRP2 3.2459 4.1187 3.2452 18.6463
KNS-81-FD GDSC2 3.2534 5.1304 2.36 6.2929
D-336MG GDSC2 3.5039 6.6671 1.7985 9.1168
D-566MG GDSC2 3.5456 6.2832 2.0233 7.5913
SF295 GDSC2 3.5473 10.7662 -0.2141 20.2914
D-502MG GDSC2 3.5546 7.7485 1.2995 12.0532
DBTRG-05MG GDSC2 3.9331 6.9779 1.9749 6.9013
SF126 GDSC2 4.2873 6.4782 2.4574 3.2211
LN-229 GDSC2 4.5833 13.2027 -0.6106 19.2756
Onda 11 GDSC2 4.8653 11.8275 0.2768 14.3995
LN-405 GDSC2 4.9668 6.6998 2.7277 0.9269
NMC-G1 GDSC2 5.0851 10.5709 1.0407 9.8229
Onda 10 GDSC2 5.6656 7.4678 2.7302 0.4595
8-MG-BA GDSC2; CTRP2 6.4102 11.4327 3.6487 9.3674
⏷ Show the Full List of 60 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ETK-1 GDSC2 2.1844 4.1256 1.7961 13.5758
TGBC24TKB GDSC2 2.3972 4.4567 1.875 12.2598
TGBC1TKB GDSC2 2.9632 6.2528 1.5478 12.2969
Cancer Drug Sensitivity Data Curated from 12 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
AN3-CA GDSC2; CTRP2 -0.3644 14.2901 -4.1541 46.282
JHUEM-3 CTRP2 1.5303 5.9716 1.1377 31.37
ESS-1 GDSC2; CTRP2 2.2071 4.1235 2.186 25.6353
MFE-296 GDSC2; CTRP2 2.2861 6.5482 1.795 26.7382
JHUEM-7 CTRP2 2.398 4.4871 2.3578 24.4278
JHUEM-1 CTRP2 2.443 2.8978 2.443 23.9927
HEC-1-A CTRP2 2.5503 3.5951 2.5497 23.2804
RL95-2 GDSC2 2.576 3.5088 2.4501 8.1642
KLE GDSC2 2.717 4.3024 2.2674 8.6722
MFE-319 GDSC2; CTRP2 2.8748 4.3728 2.8618 21.1598
MFE-280 GDSC2 3.0817 9.2896 0.1356 19.9905
EN GDSC2; CTRP2 3.3692 3.9646 3.3691 17.8229
⏷ Show the Full List of 12 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-704 GDSC2 0.0593 3.7177 -0.3541 34.6478
CAL-54 GDSC2; CTRP2 0.2937 3.4614 0.2413 38.4726
KMRC-2 CTRP2 0.5648 3.9873 0.475 36.7863
KMRC-3 CTRP2 0.8709 3.882 0.8095 34.6664
TUHR14TKB CTRP2 0.9547 4.8468 0.765 66.7643
UO-31 GDSC2; CTRP2 1.0456 4.3256 0.9442 33.634
LB996-RCC GDSC2 1.5921 4.0975 1.1773 19.6202
NCC021 GDSC2 1.6346 5.9793 0.416 23.6748
KMRC-1 GDSC2; CTRP2 1.9316 4.8075 1.8232 27.7667
769-P GDSC2 1.9499 3.5692 1.7504 14.8368
SW13 GDSC2 2.0174 4.4553 1.484 16.0812
BFTC-909 GDSC2 2.0221 4.2608 1.57 15.5599
KTCTL-26A GDSC2 2.0329 3.4593 1.8754 13.7732
BB65-RCC GDSC2 2.0927 3.762 1.8389 13.7151
Caki-1 GDSC2; CTRP2 2.163 6.6637 1.6246 27.7099
RCC10RGB GDSC2; CTRP2 2.2147 4.9251 2.1087 25.8738
KTCTL-13 GDSC2 2.275 3.7923 2.0236 11.882
VMRC-RCZ GDSC2; CTRP2 2.3414 4.8641 2.2536 24.9675
KTCTL-140 GDSC2 2.3969 3.6263 2.2155 10.2665
KTCTL-195 GDSC2 2.448 3.8328 2.1925 10.1807
RXF 393L GDSC2 2.4867 5.2376 1.6024 13.5778
KMRC-20 GDSC2 2.626 3.8559 2.3711 8.4072
NCC010 GDSC2 2.6786 4.6184 2.0823 9.9436
KTCTL-1M GDSC2 2.6976 4.316 2.2417 8.9009
OS-RC-2 GDSC2 2.7146 5.6773 1.6064 12.7533
HA7-RCC GDSC2 2.8159 5.0135 2.0246 9.813
TK-10 GDSC2 3.094 5.9036 1.8365 10.0828
A-498 GDSC2; CTRP2 3.1303 4.2169 3.1276 19.4229
786-O GDSC2; CTRP2 3.1407 4.1384 3.1392 19.3499
KTCTL-21 GDSC2 3.2784 6.7419 1.5755 11.1551
LB2241-RCC GDSC2 3.4674 7.537 1.3343 12.0889
LB1047-RCC GDSC2 3.4794 8.0538 1.0859 13.5454
SW156 GDSC2 3.58 6.9468 1.7198 9.3985
VMRC-RCW GDSC2 3.9259 11.0453 -0.0487 18.4262
SN12C GDSC2 3.9801 12.0891 -0.5259 20.4897
ACHN GDSC2; CTRP2 4.2832 7.9706 3.3924 15.0858
Caki-2 CTRP2 4.3172 8.4301 3.2223 15.6694
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 53 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H716 GDSC2; CTRP2 -5.8318 -0.8852 -5.8547 75.8681
SNU-1033 CTRP2 -0.8672 7.8367 -2.0542 47.0824
SW48 GDSC2 1.0504 6.5769 -0.4428 30.2251
COLO 320HSR GDSC2 1.2044 3.0828 1.0716 21.9409
LoVo GDSC2 1.6662 3.6264 1.4235 17.915
CCK-81 GDSC2 1.6672 3.4504 1.4794 17.602
HT115 GDSC2 1.9177 3.4712 1.7462 15.0039
HT-29 GDSC2 2.017 3.5389 1.8331 14.0789
T84 GDSC2; CTRP2 2.0311 4.2108 1.9969 26.852
C2BBe1 GDSC2; CTRP2 2.1571 3.5802 2.1539 25.9084
COLO205 GDSC2 2.1861 4.2256 1.7567 13.7992
NCI-H747 GDSC2; CTRP2 2.1991 4.404 2.1565 25.7612
GP2d CTRP2 2.2577 4.3453 2.2231 25.3437
HT-55 GDSC2 2.314 3.7838 2.0686 11.4585
SNU-175 GDSC2 2.3239 3.9778 2.0033 11.794
HCT 116 GDSC2 2.3364 3.767 2.0989 11.1893
CaR-1 GDSC2 2.3502 4.0442 2.0039 11.682
LS123 GDSC2 2.4251 3.9911 2.1044 10.7882
HCC2998 GDSC2 2.4283 3.9297 2.1329 10.6088
MDST8 GDSC2 2.4455 3.3114 2.3684 9.2008
COLO 678 GDSC2; CTRP2 2.4719 4.7312 2.4101 24.0092
SW948 GDSC2; CTRP2 2.4792 3.4557 2.4789 23.7529
HCT 15 GDSC2; CTRP2 2.55 3.7127 2.5486 23.2851
DiFi GDSC2 2.5655 3.7508 2.3496 8.782
GP5d GDSC2 2.6058 3.5057 2.4835 7.8459
LS411N GDSC2 2.6367 4.0268 2.3095 8.728
LS1034 GDSC2; CTRP2 2.6669 3.6947 2.6662 22.5038
SNU-C5 GDSC2 2.6831 3.9816 2.377 8.1433
COLO 320 CTRP2 2.6969 4.0386 2.6918 22.3187
KM12 GDSC2 2.8115 3.6953 2.6321 6.1221
SW1463 GDSC2 2.8154 5.0416 2.0105 9.9025
SNU-503 CTRP2 2.8229 4.0357 2.8197 21.4727
SW837 GDSC2 2.989 5.3286 2.0292 9.2056
HCT 8 CTRP2 3.0229 4.5254 3.0066 20.1844
CW-2 GDSC2 3.0755 5.1123 2.2139 7.7664
CL-11 GDSC2 3.0985 7.013 1.2871 13.473
HCC-56 CTRP2 3.1323 3.9407 3.1321 19.4015
SW1417 GDSC2; CTRP2 3.1679 5.4493 3.0454 19.5837
NCI-H508 GDSC2 3.1812 5.8394 1.9441 9.138
LS180 GDSC2 3.1842 7.1291 1.3024 13.1175
SNU-C1 GDSC2; CTRP2 3.1948 5.1187 3.1297 19.2053
SNU-C2B GDSC2 3.3304 7.7091 1.1354 13.6854
SW1116 GDSC2 3.3746 5.5254 2.2637 6.548
SK-CO-1 GDSC2 3.4391 8.2979 0.931 14.5699
SNU-407 GDSC2 3.4437 7.1563 1.5052 11.11
RKO GDSC2 3.4585 6.7937 1.6985 9.8687
RCM-1 [Human ESC] GDSC2; CTRP2 3.5866 5.5412 3.4809 16.7366
SW620 GDSC2 3.7032 5.8201 2.3746 4.9759
SW626 GDSC2 3.8659 6.6485 2.0874 6.3671
SNU-C4 CTRP2 3.9453 6.1341 3.7285 14.7456
SNU-61 GDSC2 4.3291 7.9165 1.8002 7.051
SNU-81 GDSC2 4.4113 7.4261 2.0912 5.1316
SNU-283 GDSC2 4.5419 11.8099 0.0468 16.3387
⏷ Show the Full List of 53 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC2 2.2448 3.4624 2.1053 11.5526
Cancer Drug Sensitivity Data Curated from 19 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Hep 3B2.1-7 GDSC2 0.3819 3.8642 -0.0496 31.6274
JHH-4 GDSC2; CTRP2 1.0684 4.1337 0.9918 33.4025
JHH-2 GDSC2; CTRP2 1.9816 4.5129 1.9157 27.2891
Huh-7 GDSC2 2.0348 5.5672 1.0045 18.8272
HLE GDSC2 2.1029 5.4229 1.139 17.7817
JHH-5 CTRP2 2.3644 3.1442 2.3644 24.5166
HLF CTRP2 2.4122 4.9376 2.3186 24.5158
SNU-449 GDSC2; CTRP2 2.4773 4.0202 2.4687 23.7932
HuH-1 GDSC2; CTRP2 2.5133 3.4952 2.513 23.5258
SNU-423 GDSC2; CTRP2 2.6106 3.4936 2.6104 22.8773
JHH-1 GDSC2; CTRP2 2.6488 4.4882 2.6203 22.7178
JHH-7 GDSC2 3.0069 5.2174 2.1003 8.7013
PLC/PRF/5 CTRP2 3.1448 3.9711 3.1445 19.3184
SNU-387 GDSC2; CTRP2 3.1892 4.962 3.1436 19.1758
SNU-398 GDSC2 3.2639 4.8425 2.5127 5.2949
SK-HEP-1 GDSC2; CTRP2 3.4758 4.0971 3.4757 17.1127
SNU-475 CTRP2 3.6003 6.4525 3.2554 17.5074
JHH-6 GDSC2; CTRP2 4.0884 5.0704 4.0773 13.0681
Hep-G2/C3A GDSC2 4.19 7.3138 1.995 6.1809
⏷ Show the Full List of 19 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 200 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H1703 GDSC2; CTRP2 -2.6259 12.1753 -5.5874 53.9189
NCI-H146 GDSC2; CTRP2 -0.7357 8.1435 -2.0184 46.4789
HCC2935 CTRP2 -0.4411 4.8456 -0.7458 43.7973
NCI-H2795 GDSC2 -0.331 2.757 -0.5258 37.5113
HCC827 GDSC2 0.0667 4.6381 -0.6605 35.8185
PC-14 GDSC2 0.6143 5.1759 -0.2858 31.5508
PaCa-3 GDSC2 0.7048 4.9472 -0.0981 30.2817
NCI-H2227 GDSC2 0.7267 10.2509 -2.4873 37.7962
NCI-H520 GDSC2; CTRP2 0.964 4.1517 0.8791 34.1229
COR-L105 GDSC2; CTRP2 0.9937 3.8269 0.9434 33.8137
A-427 GDSC2 1.0337 4.237 0.5263 25.6539
NCI-H1581 GDSC2 1.0505 6.5714 -0.4401 30.2135
COR-L47 CTRP2 1.0882 6.9107 0.3764 35.156
NCI-H446 GDSC2 1.124 3.9529 0.7255 24.1788
CPC-N GDSC2 1.217 3.3569 1.0151 22.1856
NCI-H1755 GDSC2 1.3155 4.6239 0.6775 23.5959
HARA [Human squamous cell lung carcinoma] GDSC2 1.4432 3.9668 1.0653 20.8944
NCI-H835 GDSC2 1.4992 3.6369 1.2386 19.6835
NCI-H2731 GDSC2 1.5853 4.6178 0.9643 20.855
NCI-H322M GDSC2 1.6001 3.8193 1.2869 18.9687
SBC-3 GDSC2 1.6013 3.777 1.3028 18.8741
HCC4006 CTRP2 1.625 5.1115 1.4403 30.0622
COR-L279 GDSC2 1.6568 5.7319 0.5514 22.86
NCI-H2810 GDSC2 1.6843 3.7355 1.4068 17.928
NCI-H292 GDSC2 1.69 4.6374 1.0658 19.8423
NCI-H1666 GDSC2 1.7004 4.2712 1.2258 18.8836
LK-2 GDSC2 1.7721 4.8605 1.0564 19.5609
DMS 114 GDSC2; CTRP2 1.7772 3.8089 1.7591 28.4893
NCI-H211 GDSC2 1.8333 3.6952 1.582 16.2924
NCI-H1650 GDSC2 1.9055 8.916 -0.7283 27.9577
NCI-H522 GDSC2; CTRP2 1.9251 4.9421 1.7947 27.8847
HCC78 GDSC2 1.9422 3.1902 1.8501 14.3265
EMC-BAC-2 GDSC2 1.9797 5.6601 0.9068 19.603
SK-MES-1 GDSC2; CTRP2 2.0033 3.3011 2.002 26.9266
LC-2/ad GDSC2 2.006 4.5763 1.4206 16.4995
HCC44 GDSC2 2.0307 4.1339 1.6305 15.1729
NCI-H69 GDSC2 2.0391 3.6775 1.8109 14.1054
COR-L23 GDSC2 2.0403 3.3788 1.9073 13.5654
DV-90 CTRP2 2.0482 4.5991 1.9762 26.8661
SHP-77 GDSC2 2.0527 3.8421 1.7666 14.2978
LOU-NH91 GDSC2 2.0625 5.532 1.0483 18.467
NCI-H1648 GDSC2 2.063 3.5857 1.8678 13.6816
NCI-H2030 GDSC2 2.0704 3.952 1.7441 14.3509
RERF-LC-Sq1 GDSC2 2.0767 4.7677 1.4099 16.2816
DMS 454 CTRP2 2.1104 4.3612 2.0673 26.3535
NCI-H1693 GDSC2; CTRP2 2.1171 3.8815 2.1051 26.2042
EKVX GDSC2; CTRP2 2.1391 5.2664 1.9669 26.6046
NCI-H2722 GDSC2 2.1463 4.1056 1.7641 13.9186
NCI-H2591 GDSC2 2.1719 7.3657 0.2766 22.3447
NCI-H64 GDSC2 2.1852 3.095 2.1352 11.6653
NCI-H2818 GDSC2 2.2 5.5682 1.1668 17.2522
NCI-H1792 GDSC2 2.2051 4.0371 1.8538 13.1544
NCI-H358 GDSC2 2.2416 4.3828 1.7477 13.6287
NCI-H3255 GDSC2 2.242 7.662 0.1972 22.4993
UMC-11 GDSC2 2.244 3.5339 2.0816 11.6882
NCI-H847 GDSC2 2.2762 3.1851 2.215 10.8124
HCC33 GDSC2 2.2894 3.4109 2.1696 10.9976
NCI-H1341 GDSC2; CTRP2 2.2898 4.3226 2.2583 25.1194
HOP-92 GDSC2; CTRP2 2.2899 4.2288 2.2652 25.0957
EMC-BAC-1 GDSC2 2.2936 3.9426 1.9853 12.024
LB647-SCLC GDSC2 2.2996 3.451 2.1686 10.9575
DMS 53 GDSC2; CTRP2 2.3068 5.2381 2.1539 25.4223
COR-L88 GDSC2 2.3378 4.4211 1.83 12.7603
NCI-H2461 GDSC2 2.3452 4.6809 1.7215 13.3812
IST-SL2 GDSC2 2.3541 5.9002 1.1582 16.7384
NCI-H1563 GDSC2; CTRP2 2.3686 4.1149 2.3531 24.5406
BEN GDSC2 2.3773 4.4693 1.849 12.4925
NCI-H810 GDSC2; CTRP2 2.3824 3.1362 2.3824 24.3967
HCC1438 CTRP2 2.3871 4.0437 2.3754 24.4044
Ms-1 GDSC2 2.3878 3.6511 2.1968 10.4118
NCI-H82 GDSC2 2.4053 3.2464 2.3412 9.5333
NCI-H209 GDSC2 2.4094 3.4832 2.2778 9.862
LXF 289 GDSC2 2.4335 3.5937 2.2666 9.819
NCI-H1651 GDSC2; CTRP2 2.4455 5.6722 2.2118 24.7817
NCI-H2081 GDSC2; CTRP2 2.4527 4.4677 2.4168 24.0491
HOP-62 GDSC2; CTRP2 2.4623 4.5489 2.4196 24.008
NCI-H1963 GDSC2 2.4661 4.5423 1.9062 11.8071
EPLC-272H GDSC2 2.4729 7.8649 0.3092 21.1034
COR-L311 GDSC2 2.4884 3.647 2.3066 9.3548
IST-SL1 GDSC2 2.5074 3.5526 2.3608 8.9658
A-549 GDSC2 2.5091 4.8646 1.8003 12.2882
SBC-1 GDSC2 2.5165 16.7393 -4.0693 35.0667
NCI-H2171 GDSC2; CTRP2 2.5269 3.4728 2.5267 23.4346
COR-L32 GDSC2 2.5279 4.2006 2.1218 10.2742
Lu-134-A GDSC2 2.5449 3.672 2.358 8.8202
NCI-H524 GDSC2 2.5518 3.5896 2.3958 8.5754
T3M-10 CTRP2 2.5681 3.6625 2.5672 23.1627
NCI-H1105 GDSC2; CTRP2 2.5729 3.3435 2.5729 23.1278
SBC-5 GDSC2 2.6071 5.4575 1.6125 13.0875
COR-L303 GDSC2 2.6163 3.3997 2.5293 7.5443
COR-L95 CTRP2 2.6241 3.4829 2.624 22.787
LCLC-103H GDSC2 2.6302 3.3364 2.563 7.296
NCI-H2196 GDSC2; CTRP2 2.6317 3.6587 2.6311 22.7381
NCI-H647 GDSC2; CTRP2 2.6445 3.8215 2.6426 22.6571
COLO 668 GDSC2; CTRP2 2.6628 4.5335 2.6313 22.6343
NCI-H1869 GDSC2; CTRP2 2.6802 5.5606 2.4928 23.0581
NCI-H2023 GDSC2 2.6805 4.0011 2.3658 8.22
NCI-H1568 GDSC2; CTRP2 2.6987 4.0795 2.6926 22.3096
NCI-H2804 GDSC2 2.7252 6.8664 1.0307 16.2096
LUDLU-1 CTRP2 2.7662 4.335 2.7518 21.888
NCI-H2009 GDSC2 2.7875 5.0237 1.993 10.1079
DMS 273 GDSC2; CTRP2 2.8096 3.8948 2.8082 21.5554
IA-LM GDSC2; CTRP2 2.8321 4.948 2.7659 21.6253
NCI-H1993 GDSC2 2.8336 3.828 2.5989 6.229
CAL-12T GDSC2 2.8567 5.88 1.6372 12.0874
NCI-H2029 GDSC2; CTRP2 2.857 4.6846 2.8217 21.3535
NCI-H740 GDSC2 2.8615 5.4483 1.8542 10.7204
NCI-H1155 GDSC2 2.8827 3.748 2.6841 5.5286
Lu-65 GDSC2; CTRP2 2.9103 4.8059 2.8658 21.0299
NCI-H2122 GDSC2 2.9136 3.8483 2.6717 5.4814
NCI-H2170 GDSC2; CTRP2 2.9214 4.4067 2.9082 20.8503
NCI-H1876 GDSC2 2.9355 5.2842 2.0027 9.547
NCI-H1915 GDSC2; CTRP2 2.9384 4.1493 2.9345 20.7058
NCI-H1781 GDSC2 2.943 4.9629 2.1676 8.49
NCI-H1437 GDSC2 2.9726 4.2239 2.5547 5.9788
ABC-1 GDSC2 2.977 7.1347 1.121 14.8542
NCI-H1975 GDSC2 2.9858 5.3414 2.02 9.2737
EBC-1 GDSC2 2.9862 5.7512 1.8173 10.5437
NCI-H2373 GDSC2 2.9906 4.2932 2.5385 6.0153
RERF-LC-MS GDSC2; CTRP2 3.0064 4.2471 3.0012 20.2568
NCI-H2803 GDSC2 3.0079 9.1776 0.1285 20.2591
NCI-H1688 GDSC2 3.0189 4.1891 2.6157 5.4384
COR-L51 CTRP2 3.0429 5.6756 2.8616 20.6228
NCI-H2141 GDSC2 3.0511 5.904 1.7988 10.4536
Calu-3 GDSC2 3.0536 4.5196 2.487 6.1218
Lu-165 GDSC2 3.0645 4.0297 2.7359 4.5337
VMRC-LCD GDSC2; CTRP2 3.0706 4.306 3.065 19.8305
RERF-LC-KJ GDSC2 3.0956 7.8191 0.8821 15.8871
NCI-H727 GDSC2 3.1 4.6803 2.45 6.2017
LK2 CTRP2 3.1105 3.8529 3.1104 19.5464
NCI-H23 GDSC2; CTRP2 3.1113 4.5011 3.0992 19.581
NCI-H1944 GDSC2; CTRP2 3.1228 4.4783 3.1121 19.4999
NCI-H841 GDSC2; CTRP2 3.1236 4.498 3.112 19.4975
NCI-H720 GDSC2 3.1466 4.2674 2.6961 4.5034
Lu-135 GDSC2 3.2055 4.5066 2.63 4.7317
NCI-H2110 GDSC2; CTRP2 3.2073 4.7823 3.1804 18.9914
NCI-H1092 GDSC2; CTRP2 3.2107 4.4761 3.2024 18.9063
NCI-H838 GDSC2; CTRP2 3.2277 4.7505 3.2043 18.8436
Lu-99A GDSC2 3.2439 8.0099 0.9126 15.256
HCC366 GDSC2 3.3389 9.2143 0.3899 17.8801
LC-1/sq GDSC2 3.3556 7.2922 1.3648 12.2265
NCI-H345 GDSC2 3.3571 4.4653 2.7793 3.3345
NCI-H1838 GDSC2 3.3585 4.637 2.6946 3.8668
NCI-H3122 GDSC2 3.3726 5.6507 2.1995 6.9604
NCI-H513 GDSC2 3.3823 7.0331 1.5164 11.217
LC-1/sq-SF CTRP2 3.3873 4.1396 3.387 17.7029
NCI-H1793 GDSC2; CTRP2 3.4764 6.1106 3.2235 17.9946
NCI-H2369 GDSC2 3.4969 5.2252 2.5119 4.6423
NCI-H322 CTRP2 3.5221 5.4177 3.4341 17.1045
ChaGo-K-1 GDSC2; CTRP2 3.5327 4.686 3.524 16.7621
NCI-H1694 GDSC2; CTRP2 3.5597 4.2504 3.5594 16.5544
NCI-H290 GDSC2 3.5709 8.6275 0.8736 14.5212
NCI-H526 GDSC2 3.6036 7.0534 1.6855 9.5478
NCI-H596 GDSC2 3.6325 7.4448 1.5132 10.5338
NCI-H2087 GDSC2 3.6673 6.3379 2.0913 6.8413
NCI-H1770 GDSC2 3.6747 5.2678 2.6251 3.4862
NCI-H1395 CTRP2 3.6927 6.6461 3.2916 17.1018
LCLC-97TM1 GDSC2 3.7236 5.9349 2.3332 5.1846
NCI-H2085 GDSC2 3.7402 7.5578 1.5417 10.0683
NCI-H250 GDSC2 3.7535 7.5463 1.5577 9.9348
SW1271 GDSC2 3.783 5.9468 2.3711 4.8046
NCI-H650 GDSC2 3.8292 6.9699 1.9015 7.6129
NCI-H2228 GDSC2 3.8403 10.8599 -0.0243 18.5441
NCI-H661 GDSC2 3.8456 7.3745 1.7138 8.7334
NCI-H2347 GDSC2 3.8959 7.6843 1.5987 9.3134
NCI-H1048 GDSC2 3.9618 6.34 2.3072 4.785
NCI-H2291 GDSC2 4.0627 6.1602 2.4625 3.6269
NCI-H2066 GDSC2 4.0793 6.8096 2.1618 5.4111
NCI-H441 GDSC2 4.1032 6.8482 2.1598 5.3705
NCI-H1339 CTRP2 4.1239 5.3294 4.0917 12.9034
Calu-6 GDSC2 4.1468 8.3441 1.4608 9.5243
NCI-H226 GDSC2 4.1604 9.9863 0.6601 14.1185
KNS-62 GDSC2; CTRP2 4.2105 5.9254 4.0742 12.6917
NCI-H1436 GDSC2 4.2748 6.2818 2.5406 2.7665
NCI-H196 GDSC2 4.411 9.1345 1.2657 10.0477
NCI-H1836 GDSC2 4.4562 6.8031 2.4112 3.183
HCC15 GDSC2 4.493 8.2855 1.7353 7.0806
Calu-1 CTRP2 4.4984 7.7676 3.7023 13.301
NCI-H2444 GDSC2 4.5137 6.0785 2.7644 1.2288
NCI-H1435 GDSC2 4.5235 8.8066 1.5049 8.3814
NCI-H748 GDSC2 4.5577 7.7007 2.0569 5.0431
NCI-H1299 GDSC2 4.6038 9.3483 1.2986 9.4108
NCI-H460 GDSC2 4.6261 8.5824 1.6831 7.1061
NCI-H1573 GDSC2 4.6501 6.7905 2.5295 2.2262
NCI-H2869 GDSC2 4.6911 12.4023 -0.1338 16.8404
NCI-H2135 GDSC2 4.7624 6.5308 2.6995 1.2473
NCI-H2595 GDSC2 4.7939 9.4983 1.3577 8.6496
NCI-H2405 GDSC2 4.7956 7.8754 2.1246 4.2117
SK-LU-1 GDSC2 4.796 8.5511 1.81 6.0181
SW1573 GDSC2 4.8455 11.5564 0.3951 13.8395
COR-L321 GDSC2 4.8988 6.9152 2.607 1.5192
NCI-H2172 GDSC2 5.1077 12.1463 0.2949 13.7444
NCI-H1623 GDSC2; CTRP2 5.233 10.1815 3.266 13.3177
DMS 79 GDSC2 5.4435 6.8821 2.8554 0.2524
NCI-H510A GDSC2 5.5442 7.1501 2.798 0.3426
NCI-H1355 GDSC2 5.7014 7.9299 2.5715 0.9305
NCI-H1734 GDSC2 5.8605 7.7355 2.7089 0.4264
NCI-H2342 GDSC2; CTRP2 6.1282 10.1217 4.0752 8.1139
RERF-LC-Ad2 CTRP2 6.6901 13.8114 2.685 12.751
Hs 888.Lu CTRP2 2.8323 5.0359 2.7539 21.6659
⏷ Show the Full List of 200 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC2 2.4721 3.5688 2.317 9.3663
Cancer Drug Sensitivity Data Curated from 36 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
2004 CTRP2 -2.1049 4.1563 -2.414 53.7128
IGROV-1 GDSC2 -0.3496 3.0896 -0.624 38.002
A2780 GDSC2 0.1694 3.904 -0.2934 33.8084
Caov-4 GDSC2 1.0506 5.4812 0.0427 28.0345
COV434 CTRP2 1.7105 3.9389 1.6826 28.9662
RMG-I GDSC2 1.9054 3.8022 1.6226 15.7492
COV644 CTRP2 1.9761 4.2369 1.9374 27.2335
DOV13 GDSC2 2.2337 3.5883 2.0522 11.8978
OVISE GDSC2 2.2744 3.4314 2.147 11.1898
OVTOKO GDSC2 2.3464 4.4132 1.8423 12.653
JHOS-4 GDSC2 2.3595 5.0238 1.5785 14.1898
TOV-112D GDSC2; CTRP2 2.3725 3.7651 2.3686 24.4756
OVCAR-5 GDSC2; CTRP2 2.3735 4.8116 2.2951 24.7216
OAW28 GDSC2; CTRP2 2.4898 4.3914 2.4618 23.7751
COV362 CTRP2 2.4915 5.6491 2.2674 24.442
JHOS-2 GDSC2; CTRP2 2.5077 3.7023 2.5061 23.5672
OC 314 GDSC2; CTRP2 2.5085 3.0216 2.5085 23.5568
OAW42 GDSC2; CTRP2 2.5397 3.1807 2.5396 23.3491
OVCAR-3 GDSC2 2.5621 4.663 1.9467 11.2008
OVCAR-4 GDSC2 2.6187 6.2377 1.2433 15.2991
OVCAR-8 GDSC2 2.8936 4.1513 2.5124 6.5237
TOV-21G GDSC2 2.9369 3.8228 2.7068 5.1811
TYK-nu GDSC2 3.0085 6.8737 1.2785 13.8059
JHOM-1 CTRP2 3.1592 5.1288 3.0902 19.4556
EFO-27 GDSC2; CTRP2 3.2172 5.5185 3.085 19.2892
Caov-3 GDSC2 3.2544 4.7013 2.5752 4.928
FU-OV-1 GDSC2 3.5279 8.9994 0.653 15.8917
OV7 CTRP2 3.5929 5.5511 3.4857 16.7002
ES-2 GDSC2 3.6293 7.7882 1.3395 11.6032
OV56 GDSC2; CTRP2 3.6458 4.3928 3.6452 15.9818
OV-90 GDSC2; CTRP2 3.7127 4.6854 3.7082 15.549
OVKATE GDSC2 4.1182 9.1481 1.0429 12.0656
SK-OV-3 GDSC2 4.1593 7.5308 1.8679 7.0246
EFO-21 GDSC2; CTRP2 4.3795 5.3599 4.3587 11.1619
OVK18 GDSC2 4.5693 12.8178 -0.4307 18.5168
Kuramochi GDSC2 4.8348 10.5044 0.9 11.1532
⏷ Show the Full List of 36 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Thigh Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SYO-1 CTRP2 0.4313 5.3954 0.0829 38.3672
H-STS CTRP2 5.3633 8.7348 4.0966 9.6031
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Yamato-SS CTRP2 1.6815 4.4542 1.6044 29.3253
Aska-SS CTRP2 2.3704 2.946 2.3704 24.4769
G-402 GDSC2; CTRP2 -2.5593 3.6028 -2.8088 56.3568
A-204 GDSC2; CTRP2 -1.9053 3.7089 -2.1234 52.6625
TTC-709 CTRP2 -0.5786 3.4432 -0.6742 44.3219
G-401 GDSC2; CTRP2 -0.5192 2.9298 -0.5664 43.8381
STS-0421 GDSC2 2.0583 6.728 0.4778 21.7001
TE 617.T CTRP2 2.0755 3.3206 2.0745 26.4447
Rh41 GDSC2 2.1576 3.5159 1.9934 12.5623
KYM-1 GDSC2; CTRP2 2.1791 3.1855 2.1789 25.7521
Tm87-16 CTRP2 2.2143 4.0844 2.1956 25.5791
BT-12 CTRP2 2.2653 2.8259 2.2653 25.177
Hs 633.T GDSC2 2.2698 3.3097 2.177 11.0469
Hs 729.T CTRP2 2.3047 3.5482 2.3032 24.9194
BT-16 CTRP2 2.3709 3.0057 2.3709 24.4736
MES-SA GDSC2; CTRP2 2.4583 3.3718 2.4582 23.8913
GCT GDSC2; CTRP2 2.5193 3.5493 2.5188 23.4866
RD GDSC2; CTRP2 2.5425 3.8109 2.5398 23.3392
TE 441.T GDSC2; CTRP2 2.5802 3.2014 2.5802 23.0787
EW-8 GDSC2 2.6689 3.5232 2.5457 7.2201
SW982 GDSC2; CTRP2 2.672 3.9108 2.6691 22.4771
Rh30 GDSC2 2.7468 3.6687 2.5745 6.7238
VA-ES-BJ GDSC2 2.9938 4.9048 2.2428 7.8499
HT-1080 GDSC2; CTRP2 3.1403 4.3623 3.1344 19.3673
SK-LMS-1 GDSC2; CTRP2 3.6306 5.4187 3.5508 16.3535
SW872 GDSC2 3.7249 8.8693 0.8765 14.072
SW684 GDSC2 3.8365 5.7291 2.5155 3.7897
SK-UT-1 GDSC2; CTRP2 4.1302 6.6536 3.7622 14.0759
MFH-ino GDSC2 4.3468 10.0505 0.7689 13.0433
RKN GDSC2 5.1666 9.2648 1.7109 5.8859
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Clivus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U-CH1 CTRP2 3.4096 6.4432 3.051 18.8242
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MPP 89 GDSC2; CTRP2 1.4098 4.9612 1.2358 31.4541
IST-Mes1 GDSC2; CTRP2 1.5071 6.2353 1.0393 31.7609
NCI-H2452 GDSC2 1.776 4.8029 1.0852 19.3787
NCI-H28 GDSC2 2.7606 6.3207 1.3324 14.2808
MSTO-211H GDSC2 3.0227 11.5708 -1.0545 25.4653
JL-1 CTRP2 3.3207 4.6787 3.3058 18.1955
NCI-H2052 GDSC2 4.5912 11.843 0.0674 16.114
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
22Rv1 GDSC2 2.3893 4.5423 1.8286 12.5684
VCaP GDSC2; CTRP2 2.4383 3.4086 2.4381 24.025
LNCaP clone FGC GDSC2; CTRP2 2.5996 4.5121 2.5669 23.0596
DU145 GDSC2; CTRP2 3.5991 5.9282 3.4066 16.9613
PC-3 GDSC2 3.9008 6.2446 2.3104 4.9039
NCI-H660 GDSC2 4.6644 6.1807 2.7959 0.9253
PaCa-3 CTRP2 5.1078 8.1186 4.1514 9.9703
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC2; CTRP2 3.2173 4.7849 3.1907 18.9239
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC2 0.8 3.5367 0.5081 26.8264
Cancer Drug Sensitivity Data Curated from 38 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-16 GDSC2; CTRP2 -3.1354 2.3725 -3.261 60.024
HSC-39 GDSC2 -2.4889 1.2128 -2.5927 57.4627
KATO III GDSC2; CTRP2 -1.074 5.3678 -1.5503 47.7944
LMSU CTRP2 -0.7165 3.9625 -0.8875 45.3311
RERF-GC-1B GDSC2 0.3653 3.6374 0.0039 31.4585
NCC-StC-K140 CTRP2 0.8702 4.05 0.7913 34.7267
KE-39 CTRP2 1.6252 4.6326 1.5209 29.7916
ECC10 GDSC2 1.8883 3.5291 1.6963 15.4114
NUGC-4 GDSC2 1.9953 5.6856 0.9105 19.522
MKN1 GDSC2 2.0378 3.8526 1.7467 14.4751
HGC-27 GDSC2; CTRP2 2.1191 3.2162 2.1187 26.152
23132/87 GDSC2 2.128 4.2743 1.6756 14.5105
AGS GDSC2 2.3035 3.7272 2.0784 11.4466
SNU-216 CTRP2 2.3196 3.403 2.3191 24.8165
MKN28 GDSC2 2.4763 4.9812 1.7134 12.9389
Fu97 GDSC2 2.4945 3.7827 2.2616 9.5869
SNU-601 CTRP2 2.5053 3.0471 2.5053 23.5781
HuG1-N CTRP2 2.5211 5.1891 2.3945 23.9046
GCIY GDSC2 2.5336 4.5405 1.9748 11.1369
SK-GT-2 GDSC2 2.5603 3.9516 2.2624 9.3118
SNU-1 GDSC2; CTRP2 2.5763 3.8889 2.5727 23.117
IM95 GDSC2; CTRP2 2.6537 3.8181 2.652 22.595
ECC12 GDSC2 2.677 4.5189 2.1273 9.674
NUGC-3 GDSC2 2.894 4.708 2.2464 8.1653
Hs 746.T GDSC2; CTRP2 2.9498 3.747 2.9496 20.6172
MKN45 GDSC2 3.2204 5.1031 2.3454 6.4842
SNU-5 GDSC2 3.3286 4.7403 2.6183 4.4356
NCI-N87 GDSC2 3.4144 7.7677 1.1756 13.199
RF-48 GDSC2 3.4554 5.2668 2.4584 5.0917
MKN74 CTRP2 3.4833 4.9463 3.4555 17.1561
SCH GDSC2 3.5977 5.8915 2.2591 5.9684
MKN7 GDSC2; CTRP2 3.7609 6.2074 3.506 16.1102
SH-10-TC CTRP2 4.0376 5.3256 4.0006 13.4947
TMK-1 GDSC2 4.5741 12.3275 -0.1846 17.3719
TGBC11TKB GDSC2 4.8106 8.1943 1.9864 4.9721
OCUM-1 GDSC2 5.1399 9.3361 1.6612 6.2156
SNG-M GDSC2 2.348 3.437 2.2255 10.4258
SNU-685 CTRP2 3.285 4.7868 3.2612 18.4635
⏷ Show the Full List of 38 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 18 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW579 CTRP2 -3.6881 2.2019 -3.8266 62.9724
CGTH-W-1 GDSC2 -0.626 1.4014 -0.6512 39.7314
K5 GDSC2 2.2033 3.3705 2.0876 11.8374
8305C GDSC2 2.2427 3.3038 2.1491 11.3225
CAL-62 GDSC2 2.3955 3.5654 2.2353 10.1611
BHT-101 GDSC2 2.4764 3.6806 2.2813 9.5509
IHH-4 GDSC2 2.5189 3.8684 2.2533 9.5346
B-CPAP GDSC2 2.6458 3.3478 2.5768 7.1498
KMH-2 GDSC2 2.8164 4.0425 2.4858 6.9741
FTC-238 CTRP2 3.1376 4.106 3.1364 19.3696
HTC-C3 GDSC2 3.1712 5.8645 1.9229 9.3019
8505C GDSC2 3.2797 5.1909 2.352 6.2646
ASH-3 GDSC2 4.0044 6.2164 2.3964 4.1474
TT GDSC2 4.1785 12.0925 -0.3715 19.2619
WRO GDSC2 4.1843 8.6103 1.3575 10.0509
ML-1 [Human leukemia] GDSC2 4.3159 10.5973 0.4758 14.715
TT2609-C02 GDSC2; CTRP2 4.4633 6.712 4.0996 11.8518
FTC-133 GDSC2; CTRP2 5.9651 7.6797 5.1598 3.8741
⏷ Show the Full List of 18 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 47 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DOK GDSC2 0.6022 2.7969 0.4789 27.9236
BICR 18 CTRP2 0.9857 4.845 0.7988 34.3004
JHU-022 GDSC2 1.0258 5.3488 0.0735 27.996
NCI-H3118 GDSC2 1.0943 3.8146 0.7404 24.2328
SAT [Human HNSCC] GDSC2 1.2827 7.1215 -0.4624 29.3146
BB30-HNC GDSC2 1.3114 5.5612 0.2769 25.7376
BICR 6 CTRP2 1.3404 6.0037 0.9218 32.6919
BICR 31 GDSC2; CTRP2 1.6311 4.888 1.4874 29.8846
CAL-27 GDSC2; CTRP2 1.649 3.7864 1.6281 29.3526
SAS GDSC2 1.7749 3.8956 1.4483 17.2995
KOSC-2 GDSC2 1.8889 3.9567 1.5482 16.2428
Ca9-22 GDSC2 1.94 4.1098 1.5439 16.0519
KON GDSC2 1.941 4.6049 1.3411 17.2262
BB49-HNC GDSC2 1.9473 5.7012 0.8556 20.0209
HO-1-u-1 GDSC2 1.9713 3.4518 1.8105 14.4083
HSC-3 GDSC2 2.0335 3.7977 1.7622 14.4051
BICR 78 GDSC2 2.0543 6.5294 0.5692 21.2176
JHU-011 GDSC2 2.1132 4.2027 1.6896 14.4887
CAL-33 GDSC2; CTRP2 2.1442 3.7722 2.1366 26.0088
PCI-15A GDSC2 2.2344 3.854 1.9568 12.4364
BICR 16 CTRP2 2.245 3.8366 2.2374 25.3376
BICR 10 GDSC2 2.3904 5.0274 1.6073 13.9004
JHU-029 GDSC2 2.4464 5.1515 1.604 13.7146
PCI-06A GDSC2 2.4606 7.3846 0.5347 19.9385
PE/CA-PJ34 (clone C12) CTRP2 2.4681 4.0609 2.4577 23.8604
PE/CA-PJ15 GDSC2; CTRP2 2.4912 6.9159 1.898 25.7475
PE/CA-PJ49 CTRP2 2.4998 4.6011 2.4539 23.7694
HSC-4 GDSC2 2.5374 6.4536 1.0623 16.6607
HSC-2 GDSC2; CTRP2 2.6325 4.0776 2.6252 22.7552
Detroit 562 GDSC2 2.6519 4.2988 2.2039 9.3026
SKN-3 GDSC2 2.688 4.3626 2.2107 9.1254
HO-1-N-1 GDSC2 2.6974 3.9405 2.4096 7.8933
OSC-19 GDSC2 2.7076 5.0265 1.9158 10.8648
SCC-9 GDSC2; CTRP2 2.7276 4.7394 2.6799 22.258
BICR 22 GDSC2; CTRP2 2.8114 3.6066 2.8113 21.539
PE/CA-PJ41 (clone D2) CTRP2 2.9494 6.2534 2.6075 21.8193
OSC-20 GDSC2 3.2321 5.2541 2.28 6.8624
SCC-15 GDSC2 3.2467 6.1444 1.8475 9.5487
PCI-04B GDSC2 3.347 5.5949 2.2062 6.9909
UPCI-SCC-090 GDSC2 3.5206 6.9735 1.6589 9.9414
FaDu GDSC2; CTRP2 3.5736 5.4731 3.4797 16.7822
SCC-4 GDSC2; CTRP2 3.595 4.2468 3.5948 16.3191
BHY GDSC2 3.798 7.5891 1.571 9.736
PCI-30 GDSC2 3.8535 12.6399 -0.9018 22.4299
BICR 56 CTRP2 3.9032 7.2508 3.2951 16.4893
SCC-25 GDSC2 4.4051 8.1284 1.7506 7.1809
LB771-HNC GDSC2 5.0609 8.6571 1.9265 4.8628
⏷ Show the Full List of 47 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
UM-UC-1 CTRP2 -2.1085 2.9235 -2.2352 53.9984
RT-112 GDSC2 1.0949 9.314 -1.6853 34.3663
SW780 GDSC2 1.3098 6.398 -0.1008 27.5938
SCaBER CTRP2 1.3996 4.3293 1.3202 31.2091
U-BLC1 CTRP2 1.9103 2.8513 1.9102 27.5424
RT-4 GDSC2 2.002 8.0994 -0.2397 25.4971
SW1710 GDSC2 2.0147 6.4814 0.5541 21.4497
BFTC-905 GDSC2 2.0818 3.4131 1.9426 13.1831
CAL-29 GDSC2 2.083 3.9254 1.7678 14.1616
639V GDSC2 2.3484 3.3948 2.2387 10.3518
647V GDSC2; CTRP2 2.4912 3.2623 2.4912 23.6717
TCCSUP GDSC2 2.6311 4.1873 2.2331 9.2064
KU-19-19 GDSC2 2.7366 4.3428 2.2682 8.5943
KMBC-2 CTRP2 2.7755 4.9112 2.7104 21.9981
BC-3C CTRP2 2.7973 4.3979 2.7806 21.6887
5637 GDSC2 3.6265 8.1195 1.172 12.6175
T24 GDSC2; CTRP2 3.6863 5.5927 3.5787 16.0794
J82 GDSC2; CTRP2 3.7873 7.4697 3.0854 17.6128
HT-1197 GDSC2; CTRP2 3.8263 4.8978 3.816 14.8118
UM-UC-3 GDSC2 4.7816 10.5359 0.8471 11.5673
HT-1376 GDSC2 5.3796 13.4186 -0.1313 15.2093
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BPH-1 GDSC2 0.5524 3.5165 0.2442 29.3618
CAL-39 GDSC2 0.7976 3.0669 0.6323 26.1869
KGN GDSC2 1.125 4.7498 0.4255 25.7768
OVCA420 GDSC2 1.2772 5.7522 0.1575 26.4859
TC-YIK GDSC2 1.361 3.9111 0.9963 21.6393
NCC-IT GDSC2 1.6811 3.8336 1.3694 18.1519
MS751 GDSC2 1.796 9.9052 -1.3142 30.5293
NT2-D1 GDSC2 1.8695 3.2598 1.7534 15.1844
Ca Ski GDSC2 2.0083 4.3743 1.5086 15.9746
SKN GDSC2 2.1231 6.7812 0.514 21.263
PWR-1E GDSC2 2.132 5.4988 1.1325 17.71
NEC8 GDSC2 2.2101 3.2167 2.1355 11.5469
SKG-IIIa GDSC2 2.2736 4.48 1.7383 13.5584
C-33 A GDSC2 2.3276 4.045 1.9798 11.9155
ME-180 GDSC2 2.3399 7.596 0.32 21.5136
PA-1 GDSC2 2.3503 3.4627 2.2201 10.4455
JEG-3 GDSC2 2.4152 3.8211 2.1622 10.4932
JAR GDSC2 2.4252 3.6021 2.2547 9.9218
C-4-I GDSC2 2.4789 3.4695 2.3577 9.1085
SiSo GDSC2 2.5769 4.6392 1.9723 10.9896
LB831-BLC GDSC2 2.5886 5.4447 1.6011 13.2226
HEY GDSC2 2.6036 3.9383 2.3131 8.8386
ACC-OV7 GDSC2 2.6416 4.9527 1.8879 11.2705
DSH1 GDSC2 2.6681 4.6201 2.0711 10.0503
DoTc2 4510 GDSC2 2.7325 4.0543 2.3956 7.8388
OVCA433 GDSC2 2.7431 7.855 0.5566 18.8578
OV17R GDSC2 2.7543 6.5643 1.2064 15.0643
JHOS-3 GDSC2 3.3144 8.4689 0.7422 16.0201
SW954 GDSC2 3.3987 7.0125 1.5402 11.023
OVMIU GDSC2 3.5856 7.6947 1.3512 11.6528
SW962 GDSC2 3.8365 5.8984 2.4333 4.2952
SiHa GDSC2 4.0144 6.1421 2.4389 3.8693
OMC-1 [Human cervical carcinoma] GDSC2 4.0525 9.4826 0.8272 13.4693
HEC-1 GDSC2 4.0975 6.3438 2.3982 3.9407
HT-3 GDSC2 4.1889 13.2348 -0.9319 21.6431
UWB1.289 GDSC2 4.2666 7.9942 1.7186 7.6849
PEO1 GDSC2 4.4702 9.5122 1.1238 10.7326
SW756 GDSC2 4.5456 12.807 -0.4434 18.6334
HeLa GDSC2; CTRP2 7.2881 8.2909 5.7133 0.1931
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5664).
2 Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds
3 A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22.
4 In vitro hepatic metabolism of cediranib, a potent vascular endothelial growth factor tyrosine kinase inhibitor: interspecies comparison and human enzymology. Drug Metab Dispos. 2010 Oct;38(10):1688-97.