Details of the Drug

General Information of Drug (ID: DMWVH62)

Drug Name
SCH772984
Synonyms SCH-772984
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL is unavailable 2D MOL
#Ro5 Violations (Lipinski): 1 Molecular Weight (mw) 587.7
Logarithm of the Partition Coefficient (xlogp) 2.5
Rotatable Bond Count (rotbonds) 7
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 8
Chemical Identifiers
Formula
C33H33N9O2
IUPAC Name
(3R)-1-[2-oxo-2-[4-(4-pyrimidin-2-ylphenyl)piperazin-1-yl]ethyl]-N-(3-pyridin-4-yl-1H-indazol-5-yl)pyrrolidine-3-carboxamide
Canonical SMILES
C1CN(C[C@@H]1C(=O)NC2=CC3=C(C=C2)NN=C3C4=CC=NC=C4)CC(=O)N5CCN(CC5)C6=CC=C(C=C6)C7=NC=CC=N7
InChI
InChI=1S/C33H33N9O2/c43-30(42-18-16-41(17-19-42)27-5-2-24(3-6-27)32-35-11-1-12-36-32)22-40-15-10-25(21-40)33(44)37-26-4-7-29-28(20-26)31(39-38-29)23-8-13-34-14-9-23/h1-9,11-14,20,25H,10,15-19,21-22H2,(H,37,44)(H,38,39)/t25-/m1/s1
InChIKey
HDAJDNHIBCDLQF-RUZDIDTESA-N
Cross-matching ID
PubChem CID
24866313
TTD ID
D08XVZ
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Extracellular signal-regulated kinase 2 (ERK2) TT4TQBX MK01_HUMAN Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Post-Translational Modifications [2]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Post-Translational Modifications [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Extracellular signal-regulated kinase 2 (ERK2) DTT MAPK1 6.78E-05 1.12 2.73
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC2 3.4204 9.0699 -0.1861 12.6104
CHSA0011 GDSC2 0.1955 3.2277 -0.2965 23.979
U2OS GDSC2 1.4011 5.0146 0.1479 16.631
H-EMC-SS GDSC2 2.4246 9.4356 -1.1497 20.3473
ES1 GDSC2 2.87 4.9731 1.4207 4.296
NOS-1 [Human HNSCC] GDSC2 2.8886 6.9316 0.4706 10.1138
SJSA-1 GDSC2 3.1008 9.6067 -0.6935 16.1654
CAL-78 GDSC2 3.2368 5.1284 1.588 2.5638
MG-63 GDSC2 3.2388 6.8483 0.7699 7.438
CHSA8926 GDSC2 3.2765 6.2643 1.0784 5.488
ES7 GDSC2 3.3232 6.0404 1.2163 4.5665
CAL-72 GDSC2 3.3534 9.0344 -0.2183 12.9556
U-CH2 GDSC2 3.4431 6.2009 1.2183 4.3196
ES8 GDSC2 3.5171 10.1036 -0.6234 14.73
EW-18 GDSC2 3.5991 7.5236 0.6931 7.1043
SK-ES-1 GDSC2 3.5999 7.8779 0.5234 8.104
G-292 clone A141B1 GDSC2 3.7686 7.1727 0.97 5.1446
A-673 GDSC2 3.781 6.4683 1.3015 3.2504
CADO-ES1 GDSC2 3.8596 5.5108 1.754 0.9165
EW-3 GDSC2 3.9343 7.5295 0.9077 5.1948
EW-16 GDSC2 4.0208 8.3359 0.5855 6.8733
CHSA0108 GDSC2 4.0276 16.2622 -3.2828 24.3463
MHH-ES-1 GDSC2 4.0635 6.6979 1.3582 2.5287
SaOS-2 GDSC2 4.1657 6.6277 1.4421 1.9832
HOS GDSC2 4.2274 7.1714 1.2406 2.9034
ES5 GDSC2 4.2689 7.2438 1.2316 2.8923
TC-71 GDSC2 4.3831 6.1713 1.7261 0.6243
EW-24 GDSC2 4.4358 5.7417 1.9015 0.1678
HuO9 GDSC2 4.4436 10.2337 -0.0362 9.5036
EW-12 GDSC2 4.4625 6.0754 1.7935 0.3885
EW-1 GDSC2 4.526 8.551 0.7959 4.8026
EW-7 GDSC2 4.5379 7.005 1.4682 1.4658
SK-PN-DW GDSC2 4.5575 6.5332 1.662 0.7213
ES6 GDSC2 4.6934 6.8368 1.6038 0.8253
EW-11 GDSC2 4.7678 7.9971 1.1702 2.5545
EW-13 GDSC2 4.8552 7.0537 1.5894 0.7683
ES4 GDSC2 4.9058 8.0888 1.2009 2.2555
EW-22 GDSC2 5.0115 7.2075 1.5958 0.658
HuO-3N1 GDSC2 5.1043 7.3966 1.5632 0.703
NY GDSC2 5.3968 7.6467 1.587 0.4979
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 165 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC2 3.951 6.8755 1.2167 3.4412
SU-DHL-1 GDSC2 -7.0169 16.2087 -13.3856 59.983
OCI-Ly7 GDSC2 -6.2772 -4.5689 -6.2772 85.0507
OCI-AML-2 GDSC2 -4.1781 -2.0322 -4.1806 64.9626
NB4 GDSC2 -4.0312 1.6998 -4.452 60.102
SKM-1 GDSC2 -3.0585 5.1102 -4.4919 52.3344
OCI-AML-3 GDSC2 -2.9995 4.0107 -4.0208 52.2205
JURL-MK1 GDSC2 -2.6852 0.0602 -2.7299 50.2382
A4/Fukuda GDSC2 -2.0488 2.4984 -2.4973 44.8861
Ku812 GDSC2 -1.9212 0.7842 -1.9973 42.8503
IM-9 GDSC2 -1.4923 3.3958 -2.1765 40.6084
KMOE-2 GDSC2 -1.2183 1.4794 -1.3485 36.1319
ML-2 GDSC2 -1.1732 3.3597 -1.8189 37.6859
LAMA-84 GDSC2 -0.7536 1.1847 -0.806 31.1265
EoL-1 GDSC2 -0.7134 3.2763 -1.2928 33.2012
MV4-11 GDSC2 -0.6219 2.8074 -1.0354 31.5801
Kasumi-1 GDSC2 -0.5969 5.9611 -2.2708 36.1519
NOMO-1 GDSC2 -0.5488 6.071 -2.2713 35.9277
MOLM-13 GDSC2 -0.5009 2.0702 -0.6938 29.3093
H9 GDSC2 -0.3432 4.9975 -1.5869 32.5933
TALL-1 [Human adult T-ALL] GDSC2 -0.3399 5.2954 -1.7135 33.0648
PL-21 GDSC2 -0.0808 8.6882 -3.033 35.9947
KY821 GDSC2 -0.0066 7.1558 -2.2317 33.4003
HT GDSC2 0.0073 124.4987 -60.7059 48.8238
HL-60 GDSC2 0.2122 4.8748 -0.9632 27.3561
NKM-1 GDSC2 0.5131 4.8476 -0.6459 24.4951
KOPN-8 GDSC2 0.5287 5.7489 -1.0461 26.4299
THP-1 GDSC2 0.6905 7.3585 -1.6583 28.4879
MEG-01 GDSC2 0.6999 3.2335 0.2402 18.8041
JSC-1 GDSC2 0.7442 8.1956 -2.0149 29.6635
EM-2 GDSC2 0.9703 6.422 -0.9405 24.1912
U266B1 GDSC2 0.9745 6.409 -0.9302 24.1244
OCI-AML-5 GDSC2 0.9791 6.151 -0.8012 23.4599
JVM-3 GDSC2 0.9794 8.2718 -1.8346 28.108
OCI-M1 GDSC2 1.0602 4.6216 0.0044 18.7316
MC116 GDSC2 1.1413 52.1082 -23.5618 45.9271
NCI-H929 GDSC2 1.2204 6.7872 -0.8841 22.9883
SUP-B8 GDSC2 1.4442 4.8172 0.2841 15.6619
CTB-1 GDSC2 1.7995 26.5134 -10.2119 40.3657
RPMI-8402 GDSC2 2.0341 5.8127 0.3312 13.4048
BV-173 GDSC2 2.0357 5.935 0.2717 13.7616
MY-M12 GDSC2 2.0813 6.6609 -0.0512 15.5442
CML-T1 GDSC2 2.1263 6.2164 0.2094 13.8575
MOLP-8 GDSC2 2.1767 13.7288 -3.503 29.7259
OCI-Ly19 GDSC2 2.1917 8.027 -0.6399 18.4859
Mono-Mac-6 GDSC2 2.2425 6.5027 0.165 13.771
MOLM-16 GDSC2 2.2497 7.1587 -0.1569 15.6395
MOLT-13 GDSC2 2.3122 12.307 -2.6787 26.8402
VL51 GDSC2 2.3511 10.582 -1.7838 23.3882
SCC-3 GDSC2 2.3997 6.7586 0.1681 13.287
SR GDSC2 2.4001 11.2627 -2.0834 24.4416
DEL GDSC2 2.4008 7.1921 -0.0477 14.558
KCL-22 GDSC2 2.4042 6.2327 0.4346 11.6577
Farage GDSC2 2.4231 6.1693 0.4819 11.3128
BONNA-12 GDSC2 2.4477 9.0964 -0.9611 19.3603
697 GDSC2 2.4903 5.067 1.0871 7.3405
OPM-2 GDSC2 2.5184 4.8944 1.1955 6.5796
MHH-CALL-4 GDSC2 2.527 11.399 -2.0469 23.9309
AMO1 GDSC2 2.5332 7.5601 -0.1232 14.6106
SU-DHL-16 GDSC2 2.5519 5.365 0.9876 7.7985
P31/FUJ GDSC2 2.6006 8.9377 -0.7567 17.8788
K-562 GDSC2 2.6401 5.6024 0.9387 7.8686
GDM-1 GDSC2 2.7488 6.377 0.6383 9.4512
ST486 GDSC2 2.7851 7.0061 0.3538 11.0938
A3/Kawakami GDSC2 2.8024 6.5495 0.594 9.5831
SU-DHL-6 GDSC2 2.8341 5.6766 1.05 6.6772
NU-DUL-1 GDSC2 2.8412 5.6617 1.0626 6.5814
SU-DHL-5 GDSC2 2.8468 5.6516 1.0717 6.5109
JVM-2 GDSC2 2.8926 9.4315 -0.7692 17.1201
Karpas-620 GDSC2 2.9028 9.4899 -0.7903 17.2
Daudi GDSC2 2.9177 5.3817 1.2557 5.2025
NALM-6 GDSC2 2.9397 6.4239 0.7603 8.2103
PF-382 GDSC2 2.9667 5.5867 1.1907 5.4898
RPMI-8226 GDSC2 2.9684 6.5578 0.7157 8.4132
HAL-01 GDSC2 3.0342 6.8888 0.6015 8.9491
RPMI-8866 GDSC2 3.0479 7.4587 0.3306 10.5505
WSU-DLCL2 GDSC2 3.0562 6.2988 0.9072 7.0244
RPMI-6666 GDSC2 3.0923 9.2854 -0.5405 15.3831
P12-Ichikawa GDSC2 3.0953 7.916 0.1404 11.5564
DND-41 GDSC2 3.1402 7.2221 0.5159 9.2084
MOLT-16 GDSC2 3.1408 5.84 1.1897 5.1067
BC-3 GDSC2 3.1442 5.3287 1.4361 3.6196
SIG-M5 GDSC2 3.1549 4.3588 1.8853 1.0874
CESS GDSC2 3.1749 6.7469 0.7737 7.5623
Loucy GDSC2 3.1854 5.3755 1.4408 3.5109
BALL-1 GDSC2 3.2006 6.1246 1.0937 5.5587
SUP-M2 GDSC2 3.2047 4.7678 1.7328 1.813
KG-1 GDSC2 3.2235 5.5863 1.366 3.8776
U-698-M GDSC2 3.2289 5.7187 1.3069 4.2176
SUP-B15 GDSC2 3.2569 8.3168 0.0635 11.5975
SUP-T1 GDSC2 3.2702 5.4193 1.4741 3.1563
KMS-11 GDSC2 3.2765 7.4064 0.5246 8.83
SUP-HD1 GDSC2 3.2967 11.5336 -1.4989 19.5223
Namalwa GDSC2 3.3227 8.493 0.0255 11.6539
GA-10 GDSC2 3.3259 5.1682 1.6228 2.2204
WSU-NHL GDSC2 3.331 5.9709 1.2543 4.3258
DG-75 GDSC2 3.3471 5.7235 1.3807 3.5543
ARH-77 GDSC2 3.3892 9.1111 -0.2295 12.9289
KE-37 GDSC2 3.3917 5.24 1.6285 2.086
MM1.S GDSC2 3.4291 6.4255 1.1032 5.0245
KM-H2 GDSC2 3.4378 6.6939 0.9814 5.7306
L-540 GDSC2 3.4591 9.5042 -0.3712 13.5332
ALL-PO GDSC2 3.4868 10.8218 -1.0005 16.7093
JeKo-1 GDSC2 3.5031 5.1179 1.7423 1.3476
WIL2 NS GDSC2 3.512 5.8066 1.4431 2.9088
L-428 GDSC2 3.5237 5.8283 1.4402 2.9058
LC4-1 GDSC2 3.5299 6.9746 0.9089 5.9713
TUR GDSC2 3.5541 5.5213 1.5949 2.0231
ME1 GDSC2 3.5788 11.6498 -1.3404 18.0835
BC-1 GDSC2 3.5878 11.7098 -1.3633 18.1652
Karpas-422 GDSC2 3.6451 9.9355 -0.4464 13.4834
SU-DHL-10 GDSC2 3.6792 4.7125 1.983 0.2562
ROS-50 GDSC2 3.7468 7.4605 0.821 6.0513
CCRF-CEM GDSC2 3.7573 5.7211 1.6169 1.6404
BL-41 GDSC2 3.7692 5.2546 1.8147 0.754
VAL GDSC2 3.7707 7.8233 0.6647 6.9144
HEL GDSC2 3.7792 4.9119 1.9495 0.2976
P32/ISH GDSC2 3.79 5.3056 1.8039 0.7784
MHH-CALL-2 GDSC2 3.8323 5.9326 1.5656 1.7965
CA46 GDSC2 3.8661 6.4774 1.3463 2.8751
Karpas-1106P GDSC2 3.8665 11.5358 -1.0697 16.1075
Karpas-299 GDSC2 3.88 7.3443 0.96 4.9962
Raji GDSC2 3.9048 5.5325 1.766 0.8295
MOLT-4 GDSC2 3.9088 7.5159 0.8982 5.296
ATN-1 GDSC2 3.9186 6.4603 1.3831 2.6039
ALL-SIL GDSC2 3.9451 5.94 1.6196 1.4097
BE-13 GDSC2 3.9475 8.6843 0.3722 8.2417
Hs 445 GDSC2 3.9539 5.8779 1.6495 1.2671
Reh GDSC2 3.9613 5.6279 1.7537 0.8297
Karpas-45 GDSC2 3.9935 6.5301 1.3934 2.4454
CTV-1 GDSC2 3.9964 8.7292 0.3833 8.0774
DoHH2 GDSC2 4.0397 5.3811 1.8807 0.3568
KMS-12-BM GDSC2 4.0474 5.7158 1.7574 0.7475
SU-DHL-4 GDSC2 4.0654 14.1026 -2.186 20.4531
RC-K8 GDSC2 4.1212 5.632 1.8206 0.4865
TK [Human B-cell lymphoma] GDSC2 4.1312 5.8012 1.7607 0.6748
Karpas-231 GDSC2 4.1564 5.3708 1.9289 0.1971
L-1236 GDSC2 4.1592 8.1123 0.777 5.528
MN-60 GDSC2 4.1855 6.6748 1.4323 2.0063
L-363 GDSC2 4.1956 5.5734 1.8717 0.3094
NK-92MI GDSC2 4.2066 5.8767 1.7639 0.6137
HC-1 GDSC2 4.2474 6.9738 1.3369 2.3921
RL GDSC2 4.2502 33.9806 -11.9306 37.6328
RCH-ACV GDSC2 4.2619 6.244 1.6456 0.9969
P30/OHK GDSC2 4.2742 5.9848 1.7512 0.6119
EJM GDSC2 4.2807 6.0134 1.7431 0.634
JJN-3 GDSC2 4.2896 5.8038 1.8247 0.3869
MHH-PREB-1 GDSC2 4.2988 6.0019 1.755 0.5846
Jiyoye GDSC2 4.3775 18.0391 -3.8962 25.3528
SU-DHL-8 GDSC2 4.3806 5.7266 1.8868 0.2098
QIMR-WIL GDSC2 4.3869 8.2307 0.8594 4.6841
HDLM-2 GDSC2 4.4263 6.5621 1.5939 1.0598
Jurkat GDSC2 4.4894 5.9802 1.8379 0.2735
YT GDSC2 4.5215 6.3567 1.7135 0.5814
Ramos.2G6.4C10 GDSC2 4.5319 5.849 1.899 0.1488
LP-1 GDSC2 4.583 5.9909 1.8684 0.186
Granta-519 GDSC2 4.677 6.5986 1.6866 0.5748
SK-MM-2 GDSC2 4.7673 6.4264 1.7839 0.2916
CRO-AP2 GDSC2 4.8711 6.7201 1.7185 0.3988
HH [Human lymphoma] GDSC2 4.9992 7.1489 1.6126 0.6164
RS4;11 GDSC2 5.0239 6.5153 1.8452 0.126
EB2 GDSC2 5.2474 6.8042 1.8251 0.1136
GR-ST GDSC2 5.2639 7.4641 1.6017 0.5186
DB GDSC2 5.3682 6.9836 1.8065 0.1161
MLMA GDSC2 5.4817 16.959 -2.5599 18.7562
⏷ Show the Full List of 165 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ESO-51 GDSC2 -0.1076 2.2655 -0.3143 25.457
OACP4 C GDSC2 1.1953 5.1289 -0.1037 18.8522
HCE-4 GDSC2 1.3641 5.9042 -0.3189 19.4669
KYSE-220 GDSC2 1.7156 8.1671 -1.1201 22.4306
SK-GT-4 GDSC2 2.1604 12.5316 -2.9181 28.0576
KYSE-50 GDSC2 3.8111 7.2958 0.9394 5.2413
ESO-26 GDSC2 4.1852 8.5487 0.5905 6.53
OACM5.1 C GDSC2 4.2416 8.7718 0.5219 6.81
TE-12 GDSC2 4.2816 11.9254 -0.9609 14.6172
FLO-1 GDSC2 5.3437 13.3713 -0.933 12.267
KYAE-1 GDSC2 5.5571 7.5051 1.6959 0.2285
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC2 3.9064 8.3518 0.5032 7.5741
Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NB69 GDSC2 -4.5433 0.1668 -4.7109 65.2012
CHP-212 GDSC2 -3.4029 1.1905 -3.6571 56.1705
NB(TU)1 GDSC2 -2.269 2.5611 -2.7555 46.8112
SK-N-AS GDSC2 -0.0709 6.9158 -2.182 33.5106
LA-N-6 GDSC2 0.6545 6.282 -1.1753 26.5322
KP-N-RT-BM-1 GDSC2 1.0683 3.8746 0.3539 16.6458
SK-N-BE(2)-M17 GDSC2 1.2181 6.7181 -0.8525 22.8376
GI-ME-N GDSC2 2.0351 11.937 -2.7267 27.8146
SJNB-5 GDSC2 2.1408 10.8202 -2.0791 25.1983
SiMa GDSC2 2.4153 9.0688 -0.974 19.5209
SJNB-10 GDSC2 2.533 9.9241 -1.3047 20.7552
SK-N-FI GDSC2 2.6295 8.8334 -0.6812 17.4032
NH-12 GDSC2 2.8785 11.478 -1.8009 21.9465
MHH-NB-11 GDSC2 2.9122 10.0776 -1.0756 18.5946
SK-N-SH GDSC2 2.974 5.3335 1.3189 4.6864
KP-N-YN GDSC2 3.0874 9.0623 -0.4335 14.8212
GOTO GDSC2 3.3032 9.5311 -0.5011 14.6242
SK-N-DZ GDSC2 3.4699 6.8487 0.929 5.9759
CHP-126 GDSC2 3.6605 6.6794 1.132 4.4119
NB1 GDSC2 3.6762 6.3644 1.2868 3.5053
Kelly GDSC2 3.7519 8.7147 0.2245 9.5076
TGW GDSC2 3.8 8.0481 0.5772 7.364
SK-N-MC-IXC GDSC2 3.8567 4.9901 1.9514 0.2576
IMR-5 GDSC2 3.8852 10.7771 -0.6842 14.154
CHP-134 GDSC2 3.9161 6.1005 1.5375 1.8289
SJNB-17 GDSC2 4.021 17.7972 -4.0493 26.5622
SJNB-13 GDSC2 4.1382 6.2271 1.5951 1.3168
KP-N-YS GDSC2 4.2603 6.5881 1.5058 1.5822
SJNB-14 GDSC2 4.2724 5.8531 1.7997 0.4646
SJNB-6 GDSC2 4.515 6.0691 1.8159 0.3125
SJNB-12 GDSC2 4.5579 7.1825 1.4054 1.7148
SJNB-7 GDSC2 4.856 6.6485 1.7384 0.3586
⏷ Show the Full List of 32 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC2 1.4214 8.8668 -1.7283 26.1221
Cancer Drug Sensitivity Data Curated from 51 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DU4475 GDSC2 -5.789 -3.5415 -5.7897 79.6148
MDA-MB-231 GDSC2 1.4851 9.7457 -2.1085 27.3259
MDA-MB-175-VII GDSC2 1.8371 8.3487 -1.1044 21.8934
UACC-893 GDSC2 2.0811 8.0609 -0.7506 19.3509
HCC1569 GDSC2 2.5536 10.6333 -1.6423 22.1407
CAL-85-1 GDSC2 2.7827 10.2214 -1.2507 19.7342
HDQ-P1 GDSC2 3.0303 9.5602 -0.7252 16.4699
CAL-120 GDSC2 3.3128 6.4521 1.0129 5.7847
COLO 824 GDSC2 3.3273 9.2734 -0.3557 13.7356
YMB-1-E GDSC2 3.4776 7.7975 0.4773 8.6479
Hs 578T GDSC2 3.4839 12.7558 -1.9611 20.9442
AU565 GDSC2 3.4905 6.3232 1.1911 4.3723
HCC1500 GDSC2 3.5181 8.7269 0.0533 10.9878
HCC1419 GDSC2 3.6113 8.5094 0.2258 9.7838
CAMA-1 GDSC2 3.6183 7.344 0.7917 6.46
MDA-MB-453 GDSC2 3.6868 10.6177 -0.7507 14.9248
MDA-MB-157 GDSC2 3.8485 8.5088 0.3896 8.3215
MDA-MB-436 GDSC2 3.8498 6.7553 1.212 3.6182
HCC70 GDSC2 3.9305 15.9208 -3.1879 24.2294
BT-483 GDSC2 3.9336 7.545 0.9001 5.2215
UACC-812 GDSC2 3.9349 6.8369 1.2248 3.4227
HCC2218 GDSC2 3.9742 9.743 -0.1182 10.9078
JIMT-1 GDSC2 4.035 5.4409 1.8568 0.4254
BT-474 GDSC2 4.0451 8.256 0.6386 6.5007
Evsa-T GDSC2 4.0658 5.5484 1.8292 0.4908
HCC1428 GDSC2 4.114 7.5507 1.007 4.3103
HCC2157 GDSC2 4.115 5.9058 1.7131 0.8594
HCC1395 GDSC2 4.1161 9.614 0.041 9.7243
HCC38 GDSC2 4.1205 6.5894 1.4351 2.0649
MFM-223 GDSC2 4.1226 10.0993 -0.1876 10.9617
MRK-nu-1 GDSC2 4.1715 5.6839 1.8218 0.4534
BT-549 GDSC2 4.2077 11.1529 -0.6378 13.1396
T-47D GDSC2 4.2225 11.8035 -0.9435 14.6261
CAL-148 GDSC2 4.2312 5.7227 1.8313 0.3959
HCC1806 GDSC2 4.3039 17.863 -3.865 25.3834
HCC1187 GDSC2 4.3057 6.3849 1.6096 1.0969
EFM-19 GDSC2 4.306 11.3837 -0.6809 13.1405
MDA-MB-361 GDSC2 4.3252 7.7736 1.0291 3.855
OCUB-M GDSC2 4.4315 6.3307 1.686 0.7218
BT-20 GDSC2 4.4488 11.7019 -0.7357 13.1035
HCC1954 GDSC2 4.4946 9.2075 0.4773 6.5718
ZR-75-30 GDSC2 4.5996 6.5245 1.6828 0.6276
MCF-7 GDSC2 4.6808 7.1419 1.4793 1.2866
EFM-192A GDSC2 4.8498 7.5139 1.4084 1.4204
MDA-MB-330 GDSC2 4.8856 7.5049 1.4282 1.317
MDA-MB-468 GDSC2 5.0143 11.5988 -0.3106 9.8064
HCC1143 GDSC2 5.1006 15.2585 -2.0025 17.3823
HCC1599 GDSC2 5.304 6.8799 1.8192 0.1114
HCC1937 GDSC2 5.32 12.6714 -0.6185 10.7714
CAL-51 GDSC2 6.3585 15.5405 -1.3027 12.0502
MDA-MB-415 GDSC2 7.041 19.3457 -2.6516 16.1481
⏷ Show the Full List of 51 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 54 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ONS-76 GDSC2 -1.3836 1.8286 -1.5988 38.1033
AM-38 GDSC2 1.1924 10.1462 -2.5672 29.9752
KALS-1 GDSC2 1.2951 7.7034 -1.2661 24.5555
D-245MG GDSC2 1.3783 6.7998 -0.7449 21.7157
SF539 GDSC2 1.6374 6.9375 -0.5786 19.9455
A-172 GDSC2 1.6494 9.7789 -1.9808 26.3664
KS-1 [Human Krukenberg tumour] GDSC2 1.6942 7.1021 -0.6095 19.9202
D-247MG GDSC2 1.81 10.5659 -2.234 26.8033
H4 GDSC2 2.7029 5.2415 1.1662 6.2802
CAS-1 GDSC2 2.8771 10.4585 -1.2934 19.7227
MOG-G-UVW GDSC2 3.028 6.2935 0.8895 7.2002
8-MG-BA GDSC2 3.1885 6.6164 0.847 7.0849
D-502MG GDSC2 3.225 12.1738 -1.8731 21.3083
LN-18 GDSC2 3.2277 10.6647 -1.1207 17.9604
GI-1 GDSC2 3.3103 5.7466 1.3466 3.8232
KNS-81-FD GDSC2 3.3167 8.4442 0.0451 11.5563
SF126 GDSC2 3.3999 6.6771 0.964 5.9136
SF268 GDSC2 3.4129 11.5052 -1.3952 18.7555
U-118MG GDSC2 3.4571 6.3412 1.1613 4.6267
NMC-G1 GDSC2 3.4643 5.3551 1.6183 2.031
42-MG-BA GDSC2 3.5428 7.3156 0.7547 6.8589
GB-1 GDSC2 3.5527 5.4835 1.6108 1.9424
Hs 683 GDSC2 3.6141 8.7924 0.0901 10.5886
D-263MG GDSC2 3.6215 6.5395 1.1727 4.2496
DK-MG GDSC2 3.6437 14.5498 -2.7284 23.4552
SK-MG-1 GDSC2 3.6804 8.5964 0.232 9.6237
SF295 GDSC2 3.7686 5.7492 1.6108 1.656
M059J GDSC2 3.7711 12.4517 -1.5918 18.726
D283 Med GDSC2 3.8128 6.1069 1.48 2.252
LN-405 GDSC2 3.8599 5.9857 1.5574 1.8022
D-423MG GDSC2 3.8709 7.5679 0.8501 5.6424
D-392MG GDSC2 3.9276 11.3928 -0.9549 15.4064
Onda 10 GDSC2 3.9468 7.1635 1.0838 4.1797
SW1088 GDSC2 3.953 6.2579 1.4895 2.017
Daoy GDSC2 4.0994 8.2118 0.6936 6.1073
D-542MG GDSC2 4.1586 7.7822 0.9281 4.6859
D-336MG GDSC2 4.2009 11.9051 -1.0084 15.0295
SW1783 GDSC2 4.2694 6.5549 1.5239 1.4931
KINGS-1 GDSC2 4.3013 11.4424 -0.7126 13.3481
U-87MG ATCC GDSC2 4.3177 11.9903 -0.9668 14.5647
SNB-75 GDSC2 4.3301 8.4843 0.71 5.6
U-251MG GDSC2 4.3934 9.6489 0.2074 8.2711
YH-13 GDSC2 4.6012 10.3444 0.0139 8.9219
PFSK-1 GDSC2 4.6334 6.8278 1.5815 0.9445
YKG-1 GDSC2 4.6624 15.0649 -2.2199 19.218
MOG-G-CCM GDSC2 4.701 6.9776 1.5529 0.997
GaMG GDSC2 4.7478 6.4801 1.7575 0.3566
Onda 11 GDSC2 4.7525 14.2363 -1.7513 17.1379
LN-229 GDSC2 4.7986 13.3397 -1.2844 15.0012
D-566MG GDSC2 4.8033 6.5246 1.7626 0.3243
KNS-42 GDSC2 4.8482 6.2011 1.89 0.1013
T98G GDSC2 4.9345 6.8815 1.6848 0.4544
DBTRG-05MG GDSC2 5.5407 22.353 -5.1541 26.1456
Becker GDSC2 5.9124 17.2759 -2.4157 17.3807
⏷ Show the Full List of 54 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TGBC24TKB GDSC2 3.1673 7.5524 0.3734 9.9976
ETK-1 GDSC2 3.5874 7.4979 0.6975 7.1034
TGBC1TKB GDSC2 4.217 8.7375 0.5224 6.8538
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ESS-1 GDSC2 1.4933 7.8238 -1.1468 23.3079
AN3-CA GDSC2 3.139 12.6256 -2.1658 22.6989
KLE GDSC2 3.2737 8.7467 -0.1358 12.6933
MFE-280 GDSC2 3.4647 7.0478 0.8302 6.5755
RL95-2 GDSC2 3.5968 10.3905 -0.7055 14.9572
MFE-296 GDSC2 4.4394 10.4558 -0.1445 10.0953
EN GDSC2 4.7361 11.7524 -0.5649 11.6784
MFE-319 GDSC2 5.867 16.936 -2.2835 16.974
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 33 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TK-10 GDSC2 2.1497 7.3869 -0.3555 17.0693
SW13 GDSC2 2.1785 8.3442 -0.8096 19.4104
RXF 393L GDSC2 2.7736 10.9364 -1.6149 21.451
KTCTL-140 GDSC2 2.8743 8.6826 -0.4106 15.2686
BB65-RCC GDSC2 3.1291 7.1221 0.5568 8.988
A-498 GDSC2 3.1649 8.8748 -0.2812 13.7835
RCC10RGB GDSC2 3.1953 8.0065 0.1706 11.128
KTCTL-21 GDSC2 3.2937 10.6538 -1.0644 17.5164
SN12C GDSC2 3.3144 8.3868 0.0716 11.4087
OS-RC-2 GDSC2 3.3441 7.9749 0.2954 10.032
BFTC-909 GDSC2 3.3871 9.1074 -0.2292 12.9323
UO-31 GDSC2 3.4332 7.8191 0.4354 8.9971
KTCTL-1M GDSC2 3.4363 8.9572 -0.119 12.1959
NCC010 GDSC2 3.4651 9.6995 -0.4629 14.0122
KMRC-1 GDSC2 3.479 7.0275 0.8496 6.4299
VMRC-RCW GDSC2 3.4903 5.7744 1.4448 2.9355
A-704 GDSC2 3.4904 5.9231 1.3768 3.318
NCC021 GDSC2 3.5176 6.5483 1.1027 4.8524
KTCTL-13 GDSC2 3.5274 8.0855 0.3725 9.1524
ACHN GDSC2 3.6093 9.7624 -0.3875 13.2542
HA7-RCC GDSC2 3.7936 8.5635 0.3262 8.832
CAL-54 GDSC2 3.8084 12.0915 -1.3862 17.7227
LB2241-RCC GDSC2 3.8256 7.1343 1.0236 4.7322
KMRC-20 GDSC2 3.9241 6.6809 1.2885 3.0957
LB996-RCC GDSC2 3.9245 6.9977 1.1461 3.8717
786-O GDSC2 3.9626 9.3309 0.0726 9.908
SW156 GDSC2 4.0926 6.9987 1.2423 3.0883
KTCTL-26A GDSC2 4.1025 7.5815 0.9861 4.4594
VMRC-RCZ GDSC2 4.2631 6.8674 1.3904 2.1125
KTCTL-195 GDSC2 4.4496 6.2556 1.7219 0.5975
769-P GDSC2 4.6641 12.6924 -1.065 14.2735
LB1047-RCC GDSC2 4.9604 8.7402 0.9533 3.3607
Caki-1 GDSC2 5.0016 18.3716 -3.594 23.1471
⏷ Show the Full List of 33 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 48 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-CO-1 GDSC2 -3.3269 1.7293 -3.6916 55.149
COLO205 GDSC2 -3.1151 2.231 -3.5871 53.3745
HT-29 GDSC2 -2.6895 4.8016 -3.9794 50.0712
HCC2998 GDSC2 -2.4232 3.0447 -3.0706 48.055
HCT 116 GDSC2 -2.1225 2.9271 -2.7062 45.5848
SNU-C1 GDSC2 -1.3735 8.2636 -4.0982 43.3128
NCI-H747 GDSC2 -1.1709 6.5021 -3.0963 40.8293
LS411N GDSC2 -1.1483 4.0288 -2.0376 38.1356
MDST8 GDSC2 -0.6736 6.709 -2.6857 37.5622
HT-55 GDSC2 -0.6118 4.154 -1.516 33.5072
KM12 GDSC2 -0.0113 6.5846 -1.9685 32.4379
SW1417 GDSC2 0.0156 12.5546 -4.824 39.0689
LoVo GDSC2 0.0205 9.0836 -3.1268 35.7505
SW48 GDSC2 0.0789 11.9526 -4.4703 38.2903
CL-11 GDSC2 0.102 4.9556 -1.1115 28.4467
SW620 GDSC2 0.1329 8.9443 -2.953 34.8719
LS513 GDSC2 0.1415 3.6018 -0.498 25.2148
DiFi GDSC2 0.2942 4.9243 -0.902 26.6218
NCI-H508 GDSC2 0.4063 12.4626 -4.4217 37.1222
RCM-1 [Human ESC] GDSC2 0.4976 5.8724 -1.1344 26.89
SNU-175 GDSC2 0.5782 8.3322 -2.2365 30.9988
SW626 GDSC2 0.6082 7.6664 -1.8851 29.6963
NCI-H716 GDSC2 0.6941 5.2136 -0.6331 23.6181
RKO GDSC2 1.3193 10.1749 -2.4685 29.1536
SW948 GDSC2 1.4735 8.0796 -1.2913 23.9811
SW1463 GDSC2 1.5897 6.3844 -0.3477 18.7824
LS180 GDSC2 1.6399 7.0204 -0.6173 20.0809
SNU-407 GDSC2 1.7175 10.9175 -2.4894 27.9338
SW837 GDSC2 1.9589 6.9335 -0.2929 17.262
SNU-61 GDSC2 2.1995 9.9173 -1.5782 22.9754
CCK-81 GDSC2 2.2602 7.7806 -0.459 17.249
SW1116 GDSC2 2.3387 6.8657 0.064 14.0383
COLO 678 GDSC2 2.3965 12.7791 -2.8447 27.0865
LS1034 GDSC2 2.4917 7.2764 -0.0153 14.0584
HT115 GDSC2 2.6845 5.3242 1.1112 6.6485
LS123 GDSC2 2.7444 10.6826 -1.5118 21.0281
C2BBe1 GDSC2 2.8351 8.2508 -0.2264 14.308
SNU-283 GDSC2 3.1663 11.2761 -1.4724 19.7494
SNU-C2B GDSC2 3.5332 12.2289 -1.6618 19.574
GP5d GDSC2 3.5891 10.6917 -0.8596 15.7119
SNU-81 GDSC2 3.634 10.6628 -0.812 15.3627
SNU-C5 GDSC2 3.656 16.2524 -3.5651 26.0187
T84 GDSC2 3.739 11.2471 -1.0218 16.1408
CW-2 GDSC2 3.7578 8.3195 0.419 8.3446
CaR-1 GDSC2 4.0086 10.3768 -0.4011 12.3567
HCT 15 GDSC2 4.6398 12.3796 -0.9308 13.6489
COLO 320HSR GDSC2 4.7514 6.2791 1.8295 0.2081
SNU-1040 GDSC2 5.5075 15.2881 -1.7369 15.473
⏷ Show the Full List of 48 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC2 4.2551 5.7427 1.8334 0.3801
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Hep 3B2.1-7 GDSC2 -2.4917 0.5632 -2.5763 48.3975
JHH-2 GDSC2 2.2937 4.9749 0.9718 8.6268
SNU-387 GDSC2 2.5616 11.1851 -1.9115 23.2937
JHH-4 GDSC2 2.786 5.5467 1.0781 6.6214
HuH-1 GDSC2 2.7908 6.0648 0.8254 8.1826
JHH-1 GDSC2 2.855 11.4248 -1.7932 21.9795
SNU-398 GDSC2 3.0103 11.2349 -1.5747 20.6213
SK-HEP-1 GDSC2 3.344 5.8649 1.3126 3.9577
Hep-G2/C3A GDSC2 3.3819 8.3481 0.1401 10.8489
Huh-7 GDSC2 3.6841 8.7889 0.1413 10.1362
SNU-423 GDSC2 3.7031 10.502 -0.682 14.5771
JHH-7 GDSC2 3.7464 12.5973 -1.6823 19.1772
JHH-6 GDSC2 3.8547 14.5592 -2.571 22.3884
HLE GDSC2 3.8597 11.8128 -1.2109 16.7919
SNU-449 GDSC2 3.9821 8.2838 0.585 6.9517
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 183 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Lu-65 GDSC2 -2.0386 7.44 -4.3978 46.7531
NCI-H2795 GDSC2 -1.4019 2.0779 -1.678 38.509
NCI-H2291 GDSC2 -1.3531 4.2943 -2.3585 40.2735
Calu-6 GDSC2 -1.1937 3.877 -2.0288 38.4724
NCI-H2122 GDSC2 -0.3662 3.0506 -0.8387 29.3819
EBC-1 GDSC2 0.0751 3.1439 -0.3952 25.049
NCI-H727 GDSC2 0.08 7.1624 -2.1504 32.7681
NCI-H1648 GDSC2 0.1205 4.5642 -0.9208 27.5491
NCI-H1734 GDSC2 0.1348 4.4971 -0.877 27.2726
NCI-H3122 GDSC2 0.1759 5.7061 -1.3759 29.3977
NCI-H1437 GDSC2 0.2551 7.6849 -2.2301 32.3185
NCI-H460 GDSC2 0.2989 4.3478 -0.643 25.3783
A-549 GDSC2 0.4833 4.9796 -0.7358 25.0817
HCC44 GDSC2 0.4967 5.3946 -0.9128 25.9153
NCI-H322M GDSC2 0.6428 11.903 -3.931 35.4459
NCI-H2087 GDSC2 0.6821 7.0585 -1.5212 27.9529
RERF-LC-MS GDSC2 0.6864 5.3094 -0.6853 23.9985
A-427 GDSC2 0.7998 12.1453 -3.9095 34.8867
NCI-H2135 GDSC2 0.8674 6.1986 -0.9307 24.5341
LCLC-97TM1 GDSC2 0.9244 7.5571 -1.5354 27.0911
NCI-H1666 GDSC2 0.9366 8.7607 -2.1141 29.3169
KNS-62 GDSC2 1.0607 7.0078 -1.1403 24.8174
NCI-H1993 GDSC2 1.133 6.5438 -0.8465 23.1172
NCI-H1915 GDSC2 1.1961 6.653 -0.841 22.8596
NCI-H358 GDSC2 1.3629 8.9072 -1.8005 26.6153
NCI-H1755 GDSC2 1.6137 5.243 0.2361 15.3595
RERF-LC-Sq1 GDSC2 1.7037 9.1406 -1.6154 24.7054
NCI-H290 GDSC2 1.7255 8.6214 -1.3377 23.4123
NCI-H2110 GDSC2 1.7375 7.2027 -0.6211 19.8373
SW1271 GDSC2 1.7576 8.5081 -1.2532 22.9187
COR-L105 GDSC2 1.7702 10.6823 -2.3265 27.2631
EPLC-272H GDSC2 1.7986 9.5137 -1.7188 24.8307
HARA [Human squamous cell lung carcinoma] GDSC2 1.8542 6.5617 -0.1993 17.1232
NCI-H1581 GDSC2 1.867 11.4203 -2.6117 27.945
NCI-H1792 GDSC2 2.0063 5.0719 0.6758 11.3636
EMC-BAC-2 GDSC2 2.1998 9.2767 -1.2578 21.5353
Lu-99A GDSC2 2.2105 8.5556 -0.8883 19.7115
HCC827 GDSC2 2.2955 8.1378 -0.6081 18.0004
HOP-92 GDSC2 2.2988 6.8896 0.0188 14.4703
EKVX GDSC2 2.4045 8.5396 -0.7184 18.2541
NCI-H1944 GDSC2 2.4185 9.3756 -1.1247 20.2456
NCI-H2009 GDSC2 2.4533 6.9448 0.119 13.4239
SK-MES-1 GDSC2 2.5479 6.5352 0.4005 11.458
HOP-62 GDSC2 2.5829 8.2702 -0.4376 16.2329
NCI-H1975 GDSC2 2.5925 5.7771 0.8143 8.7747
NCI-H1623 GDSC2 2.7363 11.1996 -1.7765 22.2424
NCI-H838 GDSC2 2.7552 6.5941 0.5353 10.0677
EMC-BAC-1 GDSC2 2.7606 12.0117 -2.1624 23.7148
NCI-H292 GDSC2 2.7919 10.7576 -1.5109 20.945
NCI-H2023 GDSC2 2.7968 6.499 0.6148 9.4701
NCI-H2373 GDSC2 2.8442 11.9019 -2.04 23.0082
NCI-H647 GDSC2 2.9014 9.6558 -0.8739 17.6285
LXF 289 GDSC2 2.9627 7.4362 0.2772 11.0872
PC-14 GDSC2 2.9921 7.8596 0.0898 12.118
NCI-H513 GDSC2 3.0263 6.007 1.0283 6.3502
DMS 53 GDSC2 3.0437 6.5673 0.7666 7.9171
NCI-H1568 GDSC2 3.0736 13.9774 -2.8919 25.4518
SBC-5 GDSC2 3.0856 6.6389 0.762 7.8442
NCI-H1693 GDSC2 3.0906 18.7543 -5.2628 31.4988
NCI-H2461 GDSC2 3.1183 9.4073 -0.5809 15.5291
LC-2/ad GDSC2 3.199 6.6005 0.8622 6.9685
COLO 668 GDSC2 3.2136 8.8414 -0.2278 13.3616
IA-LM GDSC2 3.2149 6.3216 1.0085 6.0438
NCI-H1573 GDSC2 3.2447 6.8879 0.7548 7.5157
NCI-H2228 GDSC2 3.2529 9.017 -0.2849 13.5781
NCI-H2405 GDSC2 3.2545 17.3552 -4.4324 29.3052
HCC15 GDSC2 3.2659 7.5834 0.4304 9.4189
LK-2 GDSC2 3.2877 10.1018 -0.7954 16.1978
LOU-NH91 GDSC2 3.2962 9.9444 -0.711 15.7438
NCI-H1355 GDSC2 3.3017 11.2978 -1.3779 18.9657
COR-L32 GDSC2 3.3458 7.0497 0.7474 7.3318
NCI-H1793 GDSC2 3.3637 9.1777 -0.2812 13.2783
NCI-H1155 GDSC2 3.4091 8.7979 -0.0607 11.9338
SBC-3 GDSC2 3.4145 7.2133 0.7161 7.3669
NCI-H510A GDSC2 3.4222 8.2177 0.2331 10.2118
NCI-H2369 GDSC2 3.436 5.8527 1.376 3.4192
NCI-H720 GDSC2 3.4597 5.1527 1.7045 1.5908
NCI-H2810 GDSC2 3.4631 6.8108 0.9425 5.9094
NCI-H596 GDSC2 3.4647 9.069 -0.153 12.3176
NCI-H2722 GDSC2 3.4882 7.5833 0.5884 7.9651
NCI-H1703 GDSC2 3.5072 7.6239 0.582 7.9615
COR-L23 GDSC2 3.5098 13.076 -2.1001 21.4809
NCI-H748 GDSC2 3.5268 6.2602 1.2434 4.0161
PaCa-3 GDSC2 3.5286 5.8078 1.4524 2.83
SK-LU-1 GDSC2 3.5341 11.2832 -1.1929 17.5121
NCI-H1876 GDSC2 3.5393 8.9455 -0.0382 11.4934
IST-SL2 GDSC2 3.567 8.636 0.1327 10.454
NCI-H2081 GDSC2 3.5844 7.9255 0.4897 8.3359
BEN GDSC2 3.6014 11.8007 -1.398 18.2883
NCI-H3255 GDSC2 3.6194 9.6848 -0.3422 12.9851
NCI-H1781 GDSC2 3.6344 9.9947 -0.4832 13.705
IST-SL1 GDSC2 3.6427 6.4793 1.2137 3.9764
NCI-H1694 GDSC2 3.671 8.0616 0.4837 8.1825
NCI-H1048 GDSC2 3.6736 6.2373 1.343 3.1966
ABC-1 GDSC2 3.6745 7.8345 0.5951 7.5216
NCI-H2444 GDSC2 3.6767 4.8402 1.9348 0.3963
NCI-H146 GDSC2 3.6894 6.3271 1.3116 3.3449
NCI-H2803 GDSC2 3.6939 8.6456 0.2176 9.6765
CAL-12T GDSC2 3.6994 14.1824 -2.5031 22.5235
LCLC-103H GDSC2 3.7057 8.3527 0.3673 8.7851
NCI-H2347 GDSC2 3.737 8.0469 0.5356 7.7379
NCI-H1688 GDSC2 3.7531 5.6947 1.626 1.6017
NCI-H345 GDSC2 3.8014 4.6458 2.0515 0.0812
NCI-H1299 GDSC2 3.8067 14.6388 -2.6471 22.774
CPC-N GDSC2 3.8079 6.2943 1.3948 2.7046
NCI-H1092 GDSC2 3.8086 5.7125 1.6467 1.4381
Calu-3 GDSC2 3.8558 6.6254 1.2742 3.2798
NCI-H1435 GDSC2 3.8619 5.9914 1.5559 1.8067
NCI-H2818 GDSC2 3.8841 9.5551 -0.09 10.9868
SBC-1 GDSC2 3.8985 5.8892 1.6178 1.4699
NCI-H23 GDSC2 3.9172 7.0566 1.1149 4.0568
NCI-H810 GDSC2 3.9264 5.3701 1.8385 0.5501
NCI-H211 GDSC2 3.9386 9.4371 0.0049 10.3389
NCI-H835 GDSC2 3.9726 12.9488 -1.6864 18.6443
NCI-H1341 GDSC2 3.9809 5.8923 1.6566 1.2089
SHP-77 GDSC2 3.9828 5.9424 1.637 1.2923
NCI-H526 GDSC2 3.9919 5.7167 1.7324 0.8868
NCI-H1869 GDSC2 4.0296 10.507 -0.4496 12.6024
COR-L279 GDSC2 4.049 5.8147 1.7194 0.8892
NCI-H2029 GDSC2 4.0663 5.7982 1.7336 0.8211
NCI-H2172 GDSC2 4.0787 6.1043 1.6168 1.2827
NCI-H2170 GDSC2 4.0917 6.2141 1.578 1.4392
COR-L88 GDSC2 4.1095 6.1353 1.6188 1.2437
NCI-H522 GDSC2 4.1108 12.3185 -1.2753 16.4941
DMS 79 GDSC2 4.1196 6.0285 1.6666 1.0367
NCI-H2227 GDSC2 4.1233 11.9107 -1.0667 15.4872
Lu-135 GDSC2 4.1295 7.0479 1.241 3.0408
COR-L303 GDSC2 4.1569 5.4733 1.8928 0.2747
NCI-H2066 GDSC2 4.175 6.4092 1.5381 1.5286
NCI-H1651 GDSC2 4.1835 7.1076 1.2446 2.9448
NCI-H661 GDSC2 4.1873 8.4382 0.6433 6.2285
Ms-1 GDSC2 4.2 6.2519 1.6141 1.1773
NCI-H2731 GDSC2 4.2075 10.076 -0.1185 10.4379
NCI-H2085 GDSC2 4.2145 9.3845 0.216 8.5784
NCI-H2591 GDSC2 4.2207 8.7103 0.5375 6.7619
NCI-H2141 GDSC2 4.228 6.0709 1.6984 0.8255
NCI-H2171 GDSC2 4.2346 5.656 1.8569 0.329
COR-L321 GDSC2 4.2589 5.9677 1.7513 0.6212
NCI-H250 GDSC2 4.2712 6.4374 1.5726 1.2827
NCI-H841 GDSC2 4.2783 5.9092 1.7813 0.5156
NCI-H524 GDSC2 4.2828 6.4308 1.5807 1.2383
Lu-134-A GDSC2 4.2905 6.7223 1.4651 1.7325
VMRC-LCD GDSC2 4.2924 6.7551 1.4524 1.7886
NCI-H520 GDSC2 4.3582 10.8204 -0.3734 11.4803
NCI-H847 GDSC2 4.3668 5.9866 1.7883 0.448
NCI-H82 GDSC2 4.3972 6.0799 1.766 0.4951
NCI-H2595 GDSC2 4.3993 8.2828 0.8431 4.7526
HCC366 GDSC2 4.4385 8.7593 0.6494 5.7456
NCI-H64 GDSC2 4.4386 5.612 1.9467 0.1009
NCI-H1436 GDSC2 4.4492 5.779 1.8935 0.1781
NCI-H69 GDSC2 4.4732 6.5239 1.6296 0.8907
HCC33 GDSC2 4.526 6.1658 1.7854 0.3808
NCI-H1105 GDSC2 4.5293 6.3694 1.7119 0.5817
LC-1/sq GDSC2 4.5452 8.2748 0.9305 4.0569
NCI-H1563 GDSC2 4.5537 6.1032 1.8184 0.2927
NCI-H2869 GDSC2 4.5712 11.4643 -0.5378 11.8818
NCI-H196 GDSC2 4.5717 6.1227 1.8182 0.2866
LB647-SCLC GDSC2 4.5837 6.1801 1.8023 0.3173
Lu-165 GDSC2 4.6016 5.8785 1.9134 0.1143
UMC-11 GDSC2 4.6317 6.5432 1.6889 0.593
NCI-H1836 GDSC2 4.6362 6.0863 1.8547 0.1957
Lu-139 GDSC2 4.6595 6.3975 1.7533 0.4029
NCI-H1838 GDSC2 4.697 6.8717 1.592 0.8626
NCI-H2804 GDSC2 4.8064 12.1291 -0.6976 12.1983
NCI-H650 GDSC2 4.8066 15.8501 -2.4998 19.9511
NCI-H446 GDSC2 4.8141 16.798 -2.9588 21.5397
NCI-H209 GDSC2 4.836 9.4077 0.5901 5.4053
DMS 114 GDSC2 4.8607 6.5661 1.7693 0.2903
DMS 273 GDSC2 4.9035 6.5684 1.7842 0.248
NCI-H1963 GDSC2 4.9361 7.1759 1.5769 0.7583
NCI-H2196 GDSC2 4.9397 6.7627 1.7293 0.3476
SW1573 GDSC2 4.9695 7.7204 1.3807 1.4309
NCI-H226 GDSC2 5.0042 14.3524 -1.6312 16.0919
NCI-H441 GDSC2 5.0127 13.5909 -1.2584 14.4341
HCC78 GDSC2 5.0467 17.5066 -3.1367 21.6303
NCI-H1770 GDSC2 5.0948 6.665 1.8192 0.1466
NCI-H1650 GDSC2 5.1205 7.4948 1.5331 0.7845
NCI-H2030 GDSC2 5.1471 19.2584 -3.9227 23.7978
ChaGo-K-1 GDSC2 5.4529 20.4606 -4.2889 24.1848
RERF-LC-KJ GDSC2 5.5 15.9345 -2.0524 16.8027
NCI-H2342 GDSC2 5.5425 7.2724 1.7697 0.1311
COR-L311 GDSC2 5.6402 7.3053 1.7919 0.0948
NCI-H740 GDSC2 5.8492 8.1664 1.5725 0.3668
⏷ Show the Full List of 183 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC2 4.6299 6.6636 1.6429 0.7373
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYSE-150 GDSC2 0.7979 4.3165 -0.1185 20.4583
OE33 GDSC2 0.9367 6.4744 -0.9976 24.5979
EC-GI-10 GDSC2 1.4021 6.5223 -0.5867 20.8
TE-11 GDSC2 1.4665 7.7345 -1.1265 23.3038
T.T GDSC2 2.0068 7.0358 -0.3025 17.2196
OE21 GDSC2 2.2911 6.3094 0.3025 12.7959
TE-15 GDSC2 2.4267 11.4423 -2.1512 24.6238
KYSE-140 GDSC2 2.4533 8.1736 -0.4951 16.9226
KYSE-520 GDSC2 2.6225 9.3395 -0.9397 18.7438
TE-4 GDSC2 3.0602 6.2549 0.9316 6.8653
OE19 GDSC2 3.1508 6.661 0.7983 7.4686
TE-10 GDSC2 3.3749 9.6567 -0.5091 14.4849
TE-6 GDSC2 3.3878 8.3465 0.1451 10.8056
TE-9 GDSC2 3.4112 5.0556 1.7206 1.5746
TE-8 GDSC2 3.4477 10.1758 -0.7108 15.3565
KYSE-270 GDSC2 3.7283 9.8411 -0.3398 12.7129
TE-5 GDSC2 3.9176 9.5804 -0.0789 10.8507
KYSE-70 GDSC2 3.95 8.7799 0.3283 8.4874
KYSE-410 GDSC2 4.1542 14.954 -2.5397 21.5652
COLO 680N GDSC2 4.1687 11.4776 -0.823 14.1971
KYSE-180 GDSC2 4.5227 11.5664 -0.6197 12.3996
KYSE-510 GDSC2 4.5573 6.8447 1.5413 1.1539
TE-1 GDSC2 4.8934 12.2916 -0.7171 12.1175
KYSE-450 GDSC2 5.0716 14.5624 -1.6859 16.1829
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OV-90 GDSC2 -0.6359 4.5798 -1.7146 34.4916
IGROV-1 GDSC2 -0.6277 5.8622 -2.2582 36.26
Caov-4 GDSC2 -0.1709 5.2638 -1.5266 31.5575
A2780 GDSC2 0.0904 7.1212 -2.1208 32.6244
OVCAR-5 GDSC2 1.4345 10.8359 -2.6955 29.5855
ES-2 GDSC2 1.7227 7.8474 -0.9547 21.6015
JHOS-4 GDSC2 2.0529 15.7746 -4.6299 32.7694
TYK-nu GDSC2 3.1596 12.7436 -2.2083 22.8068
OAW42 GDSC2 3.1649 4.6443 1.7653 1.6992
TOV-21G GDSC2 3.2874 9.6513 -0.5726 15.0442
RMG-I GDSC2 3.399 10.3219 -0.8197 16.0351
FU-OV-1 GDSC2 3.7047 13.8019 -2.3103 21.8002
DOV13 GDSC2 3.8683 6.1285 1.5005 2.0727
OC 314 GDSC2 3.9625 8.7759 0.3385 8.4033
OV56 GDSC2 3.9779 5.3165 1.8798 0.3908
OVK18 GDSC2 3.9803 12.7373 -1.5766 18.1525
EFO-21 GDSC2 3.9853 11.6758 -1.0516 15.7378
TOV-112D GDSC2 4.0765 13.5181 -1.8897 19.2469
OVKATE GDSC2 4.0834 9.2368 0.1994 8.9396
OVTOKO GDSC2 4.3053 8.9132 0.4961 6.8353
Kuramochi GDSC2 4.3311 10.9125 -0.4362 11.8668
JHOS-2 GDSC2 4.4416 13.6137 -1.6697 17.4818
OAW28 GDSC2 4.6113 8.8916 0.692 5.224
OVCAR-3 GDSC2 4.6447 12.5758 -1.0221 14.1123
OVCAR-8 GDSC2 4.7754 13.0329 -1.1525 14.4452
EFO-27 GDSC2 5.0081 15.1835 -2.031 17.7311
Caov-3 GDSC2 5.1278 13.4904 -1.1325 13.6231
OVISE GDSC2 5.5523 15.7405 -1.9235 16.1848
SK-OV-3 GDSC2 5.6848 15.2038 -1.5781 14.4961
OVCAR-4 GDSC2 5.7348 15.0017 -1.4491 13.8479
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PSN1 GDSC2 -1.2029 3.7674 -1.7447 42.7208
HPAC GDSC2 0.0793 6.2809 -1.3065 35.043
Panc 02.03 GDSC2 0.3823 6.2328 -0.9721 32.5986
Panc 04.03 GDSC2 1.0013 7.7913 -1.0526 30.3901
HPAF-II GDSC2 1.1139 7.5218 -0.8158 29.0773
PL4 GDSC2 2.13 9.3164 -0.7186 25.1369
Capan-1 GDSC2 2.1892 10.516 -1.2578 27.0165
MIA PaCa-2 GDSC2 2.4125 11.175 -1.386 26.782
DAN-G GDSC2 2.6491 7.8274 0.4865 17.9134
HuP-T3 GDSC2 2.654 10.7212 -0.9481 24.4256
Panc 03.27 GDSC2 2.788 11.1388 -1.04 24.3866
PaTu 8988t GDSC2 2.8188 13.2277 -2.0562 27.7979
KP-2 GDSC2 3.0234 9.8925 -0.2154 20.2314
Hs 766T GDSC2 3.0791 10.8028 -0.6227 21.8641
SUIT-2 GDSC2 3.1221 6.8726 1.3774 11.6997
Panc 10.05 GDSC2 3.2285 12.8655 -1.5279 24.9333
BxPC-3 GDSC2 3.2479 13.0718 -1.6149 25.1814
MZ-PC-1 GDSC2 3.3683 13.2858 -1.6214 24.8803
Capan-2 GDSC2 3.6739 11.4223 -0.4388 19.4536
SU.86.86 GDSC2 3.9569 11.9275 -0.4638 18.8381
AsPC-1 GDSC2 3.9796 11.9895 -0.4767 18.837
QGP-1 GDSC2 4.0454 13.9752 -2.1382 20.3151
KP-4 GDSC2 4.3263 10.2168 0.6715 12.514
KP-1N GDSC2 4.462 8.655 1.5354 7.599
KP-3 GDSC2 4.5426 7.0594 2.346 3.0919
SW1990 GDSC2 4.6054 10.6757 0.6521 11.988
HuP-T4 GDSC2 4.606 11.589 0.2036 14.2147
CFPAC-1 GDSC2 4.7161 10.1899 0.9691 10.1102
YAPC GDSC2 5.3668 10.4015 1.3067 7.1035
PaTu 8902 GDSC2 5.5372 15.0885 -0.8329 16.7839
Panc 08.13 GDSC2 5.7044 13.3995 0.1039 12.3888
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MSTO-211H GDSC2 2.2409 7.8055 -0.4877 17.518
MPP 89 GDSC2 3.1776 9.202 -0.4336 14.5853
NCI-H28 GDSC2 3.4685 9.0098 -0.1212 12.1304
NCI-H2452 GDSC2 3.8157 7.4759 0.8581 5.7016
IST-Mes1 GDSC2 3.8604 13.6188 -2.1013 20.6149
NCI-H2052 GDSC2 4.9023 11.8572 -0.5048 11.041
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LNCaP clone FGC GDSC2 3.4569 6.2795 1.1901 4.4577
NCI-H660 GDSC2 3.9553 5.1097 1.9462 0.2303
22Rv1 GDSC2 3.963 11.6605 -1.0603 15.8322
DU145 GDSC2 4.6643 6.2572 1.8052 0.2819
VCaP GDSC2 4.6916 6.3443 1.7846 0.3165
PC-3 GDSC2 5.0294 7.248 1.5881 0.6709
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC2 3.8494 6.4015 1.3705 2.7715
Cancer Drug Sensitivity Data Curated from 57 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CP50-MEL-B GDSC2 -3.8936 0.9286 -4.1379 59.9669
WM35 GDSC2 -3.0149 3.3454 -3.8109 52.4754
M14 GDSC2 -2.9677 2.7951 -3.5867 52.2788
COLO 800 GDSC2 -2.9318 0.8375 -3.0852 52.4375
G-mel GDSC2 -2.6375 -0.1276 -2.6669 49.7744
SH-4 GDSC2 -2.6258 1.4672 -2.8706 49.6956
SK-MEL-30 GDSC2 -2.5593 3.8312 -3.4821 49.2944
HT-144 GDSC2 -2.5432 2.9057 -3.1577 49.1009
IPC-298 GDSC2 -2.4356 1.0561 -2.5874 47.9313
WT2-iPS GDSC2 -2.0879 1.0786 -2.2171 44.6131
MZ-MEL-7 GDSC2 -2.0433 9.22 -5.2065 47.2088
HMV-II GDSC2 -2.0039 2.3368 -2.403 44.4039
UACC-62 GDSC2 -1.932 4.4012 -3.0172 44.907
SK-MEL-28 GDSC2 -1.9156 9.5148 -5.2153 46.6753
COLO 679 GDSC2 -1.8165 4.7558 -3.032 44.2433
Mel Ho GDSC2 -1.7804 6.3447 -3.6535 44.8276
LOX-IMVI GDSC2 -1.4722 3.5375 -2.2045 40.5638
IGR-37 GDSC2 -1.1595 2.4426 -1.511 36.4823
451Lu GDSC2 -1.1541 4.1739 -2.0997 38.4668
COLO 783 GDSC2 -1.1152 7.6275 -3.5482 41.4619
G-361 GDSC2 -1.0759 3.837 -1.8875 37.3779
A-375 GDSC2 -1.0526 4.3666 -2.0676 37.8228
UACC-257 GDSC2 -0.7099 6.7216 -2.728 37.9288
LB2518-MEL GDSC2 -0.3395 6.4454 -2.2304 34.8436
MZ-MEL-2 GDSC2 -0.1802 4.6706 -1.2776 30.5514
COLO 792 GDSC2 -0.1481 8.3426 -2.9322 36.0109
Hs 938.T GDSC2 0.2504 12.2618 -4.4647 37.7743
COLO 829 GDSC2 0.3037 11.6119 -4.0962 36.9173
SK-MEL-2 GDSC2 0.347 4.3746 -0.605 24.9752
CP66-MEL GDSC2 0.6332 7.1944 -1.6332 28.608
A101D GDSC2 0.6689 8.7802 -2.3705 31.1863
MMAc-SF GDSC2 0.7675 12.2603 -3.9955 35.177
GAK GDSC2 0.8984 4.4394 -0.0727 19.8002
A-431 GDSC2 0.9989 6.9273 -1.1588 25.1334
SK-MEL-1 GDSC2 1.0091 6.4976 -0.9404 24.0455
WM278 GDSC2 1.299 16.2238 -5.4988 36.3839
SK-MEL-31 GDSC2 1.9174 10.9231 -2.3203 26.7799
WM115 GDSC2 2.3851 11.2492 -2.0892 24.5078
MeWo GDSC2 2.408 10.8932 -1.8922 23.6633
A-388 GDSC2 2.4247 9.0477 -0.9557 19.4023
A2058 GDSC2 2.4502 8.7913 -0.8065 18.5741
DJM-1 GDSC2 2.6331 8.4377 -0.4807 16.3241
Mel JuSo GDSC2 2.6526 9.6095 -1.0501 19.2012
SK-MEL-5 GDSC2 2.7093 12.2413 -2.3188 24.4453
IST-MEL1 GDSC2 2.7433 9.2525 -0.7988 17.6883
LB373-MEL-D GDSC2 2.7486 11.0534 -1.6935 21.8581
IGR-1 GDSC2 2.7896 10.4592 -1.3639 20.2915
WM1552C GDSC2 2.822 9.3131 -0.7661 17.3
RPMI-7951 GDSC2 2.9326 7.4226 0.2609 11.2623
RVH-421 GDSC2 2.9922 11.9932 -1.9671 22.3129
SK-MEL-24 GDSC2 3.0664 10.4594 -1.1442 18.5031
Hs 940.T GDSC2 3.4603 7.2373 0.7361 7.1467
SK-MEL-3 GDSC2 3.7008 23.7544 -7.268 33.6083
WM793 GDSC2 3.795 15.8398 -3.2521 24.7985
CHL-1 GDSC2 3.8457 6.958 1.1171 4.1669
VMRC-MELG GDSC2 4.0285 5.6016 1.7934 0.6337
EquiPSC Line K2 GDSC2 -2.8533 3.88 -3.8169 51.2979
⏷ Show the Full List of 57 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC2 0.9677 9.8788 -2.637 30.9701
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Hs 633.T GDSC2 0.8789 6.0917 -0.8684 24.1801
G-401 GDSC2 2.6076 7.4829 -0.0245 13.8281
G-402 GDSC2 2.8343 10.819 -1.5076 20.8117
STS-0421 GDSC2 3.1596 6.9923 0.6427 8.3945
SK-LMS-1 GDSC2 3.2228 10.3148 -0.9508 17.1468
MES-SA GDSC2 3.2852 7.9279 0.2755 10.2907
KYM-1 GDSC2 3.3788 6.4819 1.0431 5.4849
SW982 GDSC2 3.51 13.9514 -2.5348 23.1087
SW684 GDSC2 3.5402 8.6731 0.0955 10.7299
HT-1080 GDSC2 3.545 8.5061 0.1803 10.2308
SK-UT-1 GDSC2 3.6162 6.0592 1.39 3.0313
A-204 GDSC2 3.6638 8.3587 0.3355 9.0625
Rh30 GDSC2 3.742 5.8822 1.5396 2.0448
TE 441.T GDSC2 3.8939 5.3746 1.8229 0.6262
VA-ES-BJ GDSC2 3.9094 6.7746 1.2381 3.3912
MFH-ino GDSC2 3.9193 8.0865 0.6374 6.7747
EW-8 GDSC2 3.9586 5.4572 1.8189 0.5947
SW872 GDSC2 3.9679 8.7579 0.3507 8.3222
GCT GDSC2 4.4571 13.3591 -1.5342 16.8618
RD GDSC2 4.6255 20.2688 -4.8115 27.1612
RKN GDSC2 4.9693 14.9068 -1.9241 17.3841
Rh41 GDSC2 5.0939 14.6663 -1.7207 16.2827
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
AGS GDSC2 -3.7221 0.6489 -3.9042 58.9831
OCUM-1 GDSC2 -3.6766 2.613 -4.3062 57.1148
ECC10 GDSC2 -0.9269 2.6658 -1.3232 34.4433
MKN45 GDSC2 -0.2263 4.7334 -1.3523 31.0868
TGBC11TKB GDSC2 0.3633 9.968 -3.235 34.8082
NUGC-4 GDSC2 0.5057 8.4627 -2.3681 31.7928
SNU-5 GDSC2 0.8582 8.1641 -1.8936 28.7819
KATO III GDSC2 1.2484 6.9617 -0.9438 23.1845
NCI-N87 GDSC2 1.255 12.4735 -3.6683 32.8828
Hs 746.T GDSC2 1.5206 9.5156 -1.9627 26.7214
MKN28 GDSC2 1.5548 7.2444 -0.8046 21.4103
HSC-39 GDSC2 2.0412 4.5159 0.983 9.3286
23132/87 GDSC2 2.3237 7.9472 -0.4892 17.276
SK-GT-2 GDSC2 2.7414 7.3578 0.1445 12.4646
GCIY GDSC2 2.7931 5.5351 1.0892 6.5349
TMK-1 GDSC2 3.1431 12.9569 -2.3276 23.2996
SNU-16 GDSC2 3.1885 6.2682 1.016 6.0571
SCH GDSC2 3.3006 6.2328 1.1097 5.2492
RERF-GC-1B GDSC2 3.3017 11.694 -1.5747 19.8431
IM95 GDSC2 3.3041 8.7246 -0.1022 12.4276
SNU-1 GDSC2 3.4661 7.033 0.8382 6.525
MKN1 GDSC2 3.5732 8.8617 0.0272 11.0426
RF-48 GDSC2 3.6182 6.7525 1.0713 4.8424
HGC-27 GDSC2 3.7931 8.8103 0.2069 9.5179
ECC12 GDSC2 3.9525 5.2819 1.8825 0.3968
NUGC-3 GDSC2 4.0712 11.6157 -0.9601 15.0944
MKN7 GDSC2 4.1359 15.1258 -2.6383 21.9599
Fu97 GDSC2 5.0728 14.4436 -1.6278 15.9337
SNG-M GDSC2 3.0388 4.9581 1.5427 3.197
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KMH-2 GDSC2 -0.922 4.3397 -1.9185 36.6601
BHT-101 GDSC2 -0.6496 3.3409 -1.247 32.6788
IHH-4 GDSC2 0.5093 7.8832 -2.0835 30.8081
K5 GDSC2 0.7657 7.9557 -1.8778 29.0671
TT2609-C02 GDSC2 1.4102 8.5906 -1.6013 25.6316
HTC-C3 GDSC2 1.7541 8.9905 -1.4966 24.0273
CAL-62 GDSC2 2.4411 8.2764 -0.5566 17.2906
ASH-3 GDSC2 2.673 9.9256 -1.1915 19.8212
8505C GDSC2 3.1588 13.592 -2.6318 24.3513
CGTH-W-1 GDSC2 3.4293 6.166 1.2258 4.3019
TT GDSC2 3.6308 7.5394 0.7069 6.9564
WRO GDSC2 3.7755 7.7544 0.7006 6.6957
B-CPAP GDSC2 3.8826 12.2573 -1.4127 17.6619
ML-1 [Human leukemia] GDSC2 3.9419 8.559 0.4282 7.9326
8305C GDSC2 4.2677 12.8305 -1.4122 16.7523
FTC-133 GDSC2 4.7452 6.3178 1.8138 0.2391
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SAS GDSC2 -1.0314 6.9517 -3.1563 40.3737
UPCI-SCC-090 GDSC2 -0.8338 8.1936 -3.5305 40.1863
DOK GDSC2 -0.4811 7.5479 -2.8814 37.2826
JHU-029 GDSC2 -0.3099 11.166 -4.4477 39.6704
PCI-15A GDSC2 -0.0807 4.645 -1.1635 29.5882
NCI-H3118 GDSC2 0.1812 8.3887 -2.6389 33.89
BB30-HNC GDSC2 0.25 4.3427 -0.6913 25.8372
JHU-011 GDSC2 0.4159 6.2827 -1.4073 28.5287
KOSC-2 GDSC2 0.5534 6.2036 -1.236 27.2137
KON GDSC2 1.4822 8.5116 -1.4978 24.9406
Detroit 562 GDSC2 1.5325 8.0511 -1.2245 23.5387
PCI-04B GDSC2 1.5499 8.9575 -1.6594 25.4016
PE/CA-PJ15 GDSC2 1.7002 7.7078 -0.9053 21.4297
BB49-HNC GDSC2 1.7245 8.735 -1.3951 23.6752
HO-1-u-1 GDSC2 1.855 7.0787 -0.456 18.5597
HO-1-N-1 GDSC2 1.862 5.2676 0.4502 13.2257
BICR 22 GDSC2 2.4178 7.7545 -0.3149 16.0342
SKN-3 GDSC2 2.4512 13.4568 -3.1382 27.9073
JHU-022 GDSC2 2.5008 11.9868 -2.3623 25.1939
OSC-19 GDSC2 2.5544 8.8343 -0.7426 17.9394
Ca9-22 GDSC2 2.6928 12.5768 -2.4998 25.145
SCC-9 GDSC2 2.7591 13.6945 -3.0043 26.6495
HSC-2 GDSC2 2.8733 4.987 1.4162 4.316
CAL-27 GDSC2 2.9304 9.8299 -0.9378 17.8682
SAT [Human HNSCC] GDSC2 3.0588 10.5266 -1.1837 18.7109
SCC-25 GDSC2 3.1018 8.127 0.0409 12.1196
BICR 31 GDSC2 3.1494 8.2571 0.0126 12.1617
CAL-33 GDSC2 3.3586 8.8358 -0.1166 12.3736
BICR 78 GDSC2 3.375 8.6214 0.0009 11.6669
HSC-4 GDSC2 3.452 8.5116 0.1109 10.8499
SCC-15 GDSC2 3.5666 8.4088 0.2431 9.8181
HSC-3 GDSC2 3.7275 13.6173 -2.2014 21.3297
OSC-20 GDSC2 3.8127 6.4573 1.3248 3.073
LB771-HNC GDSC2 3.8483 8.0601 0.6035 7.1126
BICR 10 GDSC2 3.9083 11.1315 -0.8409 14.8897
SCC-4 GDSC2 3.9111 13.0651 -1.7896 19.2282
PCI-06A GDSC2 4.072 10.633 -0.4809 12.6712
PCI-30 GDSC2 4.0907 10.2731 -0.2935 11.6364
BHY GDSC2 4.2158 8.7501 0.5158 6.8934
FaDu GDSC2 6.7794 28.6662 -7.3452 28.2991
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KU-19-19 GDSC2 -2.4584 1.3372 -2.6629 48.1862
BFTC-905 GDSC2 -0.3595 3.6242 -1.0404 30.3189
RT-4 GDSC2 1.7687 7.7675 -0.8746 21.0483
RT-112 GDSC2 2.4036 12.9115 -2.9049 27.3169
CAL-29 GDSC2 2.8351 9.8896 -1.0432 18.6513
SW780 GDSC2 3.1107 7.4413 0.3862 10.061
5637 GDSC2 3.2737 8.0085 0.2276 10.6007
HT-1197 GDSC2 3.2754 5.948 1.2287 4.5898
SW1710 GDSC2 3.3381 8.2442 0.159 10.8447
HT-1376 GDSC2 3.9489 8.8951 0.2724 8.8083
UM-UC-3 GDSC2 4.1479 10.386 -0.3085 11.5905
647V GDSC2 4.2027 9.863 -0.0198 9.9088
TCCSUP GDSC2 4.7235 6.6723 1.678 0.5747
T24 GDSC2 5.0335 8.953 0.9004 3.5257
J82 GDSC2 5.4089 12.8712 -0.6556 10.8168
639V GDSC2 6.2358 17.5955 -2.3509 16.5292
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CAL-39 GDSC2 -0.6494 3.7844 -1.4113 33.3762
BPH-1 GDSC2 -0.5859 5.4237 -2.0223 35.3187
DSH1 GDSC2 0.8874 6.6006 -1.1053 25.3014
HEY GDSC2 1.0648 9.2509 -2.2389 29.3047
JHOS-3 GDSC2 1.0669 6.4716 -0.8733 23.4962
SW954 GDSC2 1.6263 5.8596 -0.0555 17.0483
TC-YIK GDSC2 1.7851 10.4642 -2.2048 26.7751
OVCA420 GDSC2 2.5335 7.2556 0.0291 13.7248
OVMIU GDSC2 2.5529 13.8928 -3.2722 28.0269
ACC-OV7 GDSC2 2.7485 9.325 -0.8308 17.8365
NEC8 GDSC2 2.7605 6.1898 0.7402 8.7899
OV17R GDSC2 2.8009 7.7755 -0.0167 13.2477
OVCA433 GDSC2 3.0096 10.8057 -1.3613 19.6704
OMC-1 [Human cervical carcinoma] GDSC2 3.0157 9.6074 -0.76 16.7372
UWB1.289 GDSC2 3.0398 7.6351 0.2373 11.1264
NT2-D1 GDSC2 3.0648 5.7421 1.1844 5.3057
C-33 A GDSC2 3.228 10.9724 -1.2734 18.6791
HeLa GDSC2 3.2571 7.329 0.5485 8.732
PA-1 GDSC2 3.3094 10.8225 -1.136 17.8191
DoTc2 4510 GDSC2 3.4386 8.2837 0.2127 10.2925
SKG-IIIa GDSC2 3.5037 13.8843 -2.5063 23.0224
HT-3 GDSC2 3.5088 9.8195 -0.4895 14.0458
PWR-1E GDSC2 3.6089 7.9403 0.4995 8.2247
Ca Ski GDSC2 3.713 9.1589 -0.018 10.9735
SW962 GDSC2 3.8266 9.8032 -0.251 12.0018
JEG-3 GDSC2 3.8736 10.2997 -0.4594 13.0117
KGN GDSC2 3.9408 12.3424 -1.4115 17.5161
LB831-BLC GDSC2 4.0059 11.3326 -0.8688 14.7988
HEC-1 GDSC2 4.0686 6.0184 1.6469 1.1643
C-4-I GDSC2 4.1311 13.2842 -1.7343 18.4714
JAR GDSC2 4.2489 5.9501 1.7538 0.6195
PEO1 GDSC2 4.2743 13.6585 -1.813 18.4675
MS751 GDSC2 4.431 9.8342 0.1444 8.5443
SiHa GDSC2 4.506 5.7771 1.9144 0.1316
SKN GDSC2 4.528 7.6434 1.1969 2.7214
SW756 GDSC2 4.5587 11.4278 -0.5288 11.8619
NCC-IT GDSC2 4.5983 6.9955 1.5 1.2808
SiSo GDSC2 4.8404 7.0518 1.5839 0.7951
ME-180 GDSC2 4.9268 15.0828 -2.0396 17.9382
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug

References

1 Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors. Cancer Discov. 2013 Jul;3(7):742-50.
2 3,4,5-Tri-O-caffeoylquinic acid methyl ester isolated from Lonicera japonica Thunb. Flower buds facilitates hepatitis B virus replication in HepG2.2.15 cells. Food Chem Toxicol. 2020 Apr;138:111250. doi: 10.1016/j.fct.2020.111250. Epub 2020 Mar 7.