Details of the Drug

General Information of Drug (ID: DMWXEZD)

Drug Name
PMID27376512-Compound-MTC-427
Drug Type
Nucleotide
Sequence
5CCTATG[methylcytosine]GAT[methylcytosine]GAGTTTTCT[zebulari
ne]GCATAGG3
Cross-matching ID
TTD ID
D0HA0J

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
DNA [cytosine-5]-methyltransferase 1 (DNMT1) TT6S2FE DNMT1_HUMAN Inhibitor [1]
DNA [cytosine-5]-methyltransferase 3A (DNMT3A) TTJUALD DNM3A_HUMAN Inhibitor [1]
DNA [cytosine-5]-methyltransferase 3B (DNMT3B) TT6VZ78 DNM3B_HUMAN Inhibitor [1]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
DNA [cytosine-5]-methyltransferase 1 (DNMT1) DTT DNMT1 2.06E-08 0.71 15.47
DNA [cytosine-5]-methyltransferase 1 (DNMT1) DTT DNMT1 1.27E-05 0.97 2.41
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

References

1 DNA methyltransferase inhibitors: an updated patent review (2012-2015).Expert Opin Ther Pat. 2016 Sep;26(9):1017-30.