Details of the Drug

General Information of Drug (ID: DMX04CA)

Drug Name
VB-111
Indication
Disease Entry ICD 11 Status REF
Malignant glioma 2A00.0 Phase 3 [1]
Ovarian cancer 2C73 Phase 3 [2]
Recurrent glioblastoma 2A00.00 Phase 3 [2]
Glioblastoma multiforme 2A00.0 Phase 2 [3]
Cross-matching ID
TTD ID
D0S4LV
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Apoptosis mediating surface antigen FAS (FAS) TTF0RCZ TNR6_HUMAN Modulator [4]
Tumor necrosis factor receptor type I (TNF-R1) TTG043C TNR1A_HUMAN Modulator [4]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3 VB-111 for cancer. Expert Opin Biol Ther. 2011 Dec;11(12):1669-76.
4 Phase I dose-escalation study of VB-111, an antiangiogenic virotherapy, in patients with advanced solid tumors.Clin Cancer Res.2013 Jul 15;19(14):3996-4007.