Details of the Drug

General Information of Drug (ID: DMX0TAM)

Drug Name
NSC-95397
Synonyms
NSC 95397; 93718-83-3; 2,3-Bis(2-hydroxyethylthio)-1,4-naphthalenedione; NSC95397; NSC-95397; 2,3-bis(2-hydroxyethylsulfanyl)naphthalene-1,4-dione; MLS002153403; CHEMBL429095; SMR001230781; SR-01000075930; 1,4-Naphthalenedione, 2,3-bis[(2-hydroxyethyl)thio]-; Tocris-1547; AC1Q6JAF; Lopac-N-1786; Lopac0_000629; KBioGR_000495; BSPBio_001155; KBioSS_000495; SCHEMBL2530685; AC1L66Q4; cid_262093; KBio3_000910; KBio2_005631; KBio2_003063; CHEBI:93193; KBio3_000909; KBio2_000495; CTK3I8111; DTXSID10294236; MolPort-003-958-936; HMS3268C19
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 310.4
Logarithm of the Partition Coefficient (xlogp) 1.5
Rotatable Bond Count (rotbonds) 6
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 6
Chemical Identifiers
Formula
C14H14O4S2
IUPAC Name
2,3-bis(2-hydroxyethylsulfanyl)naphthalene-1,4-dione
Canonical SMILES
C1=CC=C2C(=C1)C(=O)C(=C(C2=O)SCCO)SCCO
InChI
InChI=1S/C14H14O4S2/c15-5-7-19-13-11(17)9-3-1-2-4-10(9)12(18)14(13)20-8-6-16/h1-4,15-16H,5-8H2
InChIKey
MAASHDQFQDDECQ-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
262093
ChEBI ID
CHEBI:93193
CAS Number
93718-83-3
TTD ID
D0J1KH

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
M-phase inducer phosphatase 1 (MPIP1) TTLZS4Q MPIP1_HUMAN Inhibitor [2]
M-phase inducer phosphatase 2 (MPIP2) TTR0SWN MPIP2_HUMAN Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [3]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 125 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JK1 CTRP2 1.4668 3.3685 1.4395 23.9263
MEC1 CTRP2 1.542 2.0908 1.542 23.3337
JM1 CTRP2 0.4063 1.2466 0.4063 30.8997
P3HR-1 CTRP2; CTRP1 -1.0228 -0.2715 -1.0228 40.4779
SU-DHL-5 CTRP1 -0.7091 0.2776 -0.7091 81.9996
WSU-DLCL2 CTRP2; CTRP1 -0.6205 0.4092 -0.6205 37.8003
GDM-1 CTRP1 -0.5267 1.3136 -0.5288 77.7811
KMS-11 CTRP1 -0.4452 0.6277 -0.4452 78.312
SUP-T11 CTRP2 -0.3178 1.1614 -0.3182 35.7251
NOMO-1 CTRP1 -0.269 1.5254 -0.2714 74.7138
SKM-1 CTRP1 -0.2083 1.5504 -0.2105 74.0195
Ku812 CTRP2; CTRP1 -0.1815 1.0752 -0.1816 34.8789
KE-97 CTRP2; CTRP1 -0.1781 0.4671 -0.1781 34.8562
GA-10 CTRP2 -0.17 0.6973 -0.17 34.739
NCI-H929 CTRP2 -0.1068 0.8801 -0.1068 34.3182
OCI-AML-3 CTRP2; CTRP1 -0.0338 1.2657 -0.034 33.8959
OCI-Ly3 CTRP2 0.0782 6.0189 -0.6696 35.3147
PL21 CTRP1 0.3135 1.5995 0.3131 67.6186
MOLT-16 CTRP2 0.4341 1.7023 0.4337 30.7157
NU-DUL-1 CTRP2; CTRP1 0.4843 1.586 0.4842 30.4475
KMS-21-BM CTRP2 0.532 5.7313 -0.0835 32.0602
MC116 CTRP2; CTRP1 0.5703 1.3936 0.5703 29.875
SEM CTRP2 0.5777 2.4464 0.5688 29.7877
MOLP-8 CTRP2 0.7232 1.535 0.7232 28.7887
HT CTRP2; CTRP1 0.778 1.7041 0.7779 28.4927
PF-382 CTRP2 0.8553 1.9493 0.8551 27.909
OPM-2 CTRP2 0.9311 2.2722 0.9297 27.408
MHH-CALL-4 CTRP2 0.9395 3.1354 0.9071 27.456
ALL-SIL CTRP2 0.951 2.8635 0.9354 27.3228
SU-DHL-6 CTRP2 1.0014 2.4102 0.9991 26.9426
MOLM-6 CTRP2 1.0139 2.5033 1.0103 26.8637
KMS-28BM CTRP2 1.0379 4.9475 0.6981 27.8532
RS4;11 CTRP2 1.0675 2.0822 1.0673 26.4955
EM-2 CTRP2 1.0725 2.3672 1.0711 26.466
RCH-ACV CTRP2 1.0805 3.2225 1.0476 26.5187
Daudi CTRP2 1.0875 1.9888 1.0874 26.3618
NALM-6 CTRP2 1.0942 2.6755 1.0883 26.3362
THP-1 CTRP2; CTRP1 1.1412 2.3042 1.1406 26.0772
EoL-1 CTRP2 1.1627 3.3052 1.1269 25.9808
MM1.S CTRP2 1.3276 2.9385 1.3184 24.7926
JeKo-1 CTRP2 1.3435 2.0397 1.3435 24.6556
OCI-Ly19 CTRP2 1.3563 3.5165 1.3112 24.7225
NU-DHL-1 CTRP2 1.357 2.9859 1.3468 24.6001
ST486 CTRP2 1.4045 2.0845 1.4045 24.2495
MOLM-13 CTRP2 1.4061 2.2099 1.4061 24.239
Pfeiffer CTRP2 1.4108 2.403 1.4106 24.2082
SET-2 CTRP2 1.4353 1.9925 1.4353 24.0443
EJM CTRP2; CTRP1 1.4445 3.5944 1.397 24.2162
KHM-1B CTRP2 1.4654 2.2237 1.4654 23.8437
Kasumi-1 CTRP2 1.4835 2.8512 1.4794 23.737
LP-1 CTRP2; CTRP1 1.4974 3.2077 1.4815 23.7573
P31/FUJ CTRP2 1.511 2.0333 1.511 23.5398
Mino CTRP2 1.541 1.9431 1.541 23.3398
KMS-26 CTRP2 1.5801 2.1173 1.5801 23.0795
Hs 611.T CTRP2 1.5857 2.997 1.5799 23.0616
RPMI-8402 CTRP2 1.6048 2.9493 1.6004 22.9299
OCI-M1 CTRP2 1.6593 2.6878 1.6586 22.5543
Peer CTRP2 1.6725 2.3273 1.6724 22.4644
HL-60 CTRP2 1.6919 2.4137 1.6919 22.335
KMS-12-BM CTRP2 1.7046 2.5852 1.7044 22.2506
SU-DHL-8 CTRP2 1.7089 2.2653 1.7089 22.2215
TALL-1 [Human adult T-ALL] CTRP2 1.7156 3.0025 1.7116 22.1902
SIG-M5 CTRP2 1.7589 2.3463 1.7589 21.8881
DB CTRP2 1.7856 3.145 1.7793 21.7317
KO52 CTRP2 1.8136 2.3587 1.8136 21.5242
DEL CTRP2 1.8268 2.438 1.8268 21.4362
P12-Ichikawa CTRP2 1.84 2.8816 1.8389 21.3519
RPMI-8226 CTRP1 1.8504 3.6934 1.8145 45.9651
HPB-ALL CTRP2 1.8738 2.7152 1.8736 21.1233
KE-37 CTRP2 1.8916 2.8909 1.8907 21.0074
CML-T1 CTRP2 1.909 3.1963 1.9034 20.9071
BL-70 CTRP2; CTRP1 2.1176 3.3787 2.1155 23.1038
Granta-519 CTRP2 2.2401 4.6564 2.0805 19.2334
ME1 CTRP2 2.2516 3.5173 2.2426 18.6363
KMS-18 CTRP2 2.2523 4.1641 2.1846 18.8312
Ri-1 CTRP2 2.26 4.3405 2.1649 18.875
AML-193 CTRP2 2.2711 3.2534 2.2693 18.4818
KMS-20 CTRP2 2.335 3.1296 2.3346 18.0518
SUP-HD1 CTRP2 2.3746 3.7954 2.3541 17.8557
F-36P CTRP2 2.4427 3.8336 2.4223 17.4012
KMS-34 CTRP2 2.4817 3.604 2.475 17.0955
L-540 CTRP2 2.5183 4.58 2.3991 17.239
Kasumi-2 CTRP2 2.5236 3.3366 2.5227 16.7969
MV4-11 CTRP2 2.5383 4.1912 2.4863 16.8723
AMO1 CTRP2; CTRP1 2.5659 3.4864 2.5637 16.6001
SU-DHL-1 CTRP2 2.5791 3.7637 2.5681 16.4611
MHH-CALL-3 CTRP2 2.638 5.191 2.3767 16.9509
U-937 CTRP2; CTRP1 2.6443 3.9111 2.627 16.1288
KCL-22 CTRP2 2.7304 4.3151 2.6744 15.6064
M-07e CTRP2 2.7804 3.656 2.7777 15.0923
OCI-Ly10 CTRP1 2.8172 4.5523 2.7299 32.6376
MOLM-16 CTRP2; CTRP1 2.8329 4.1884 2.8003 14.9253
SUP-B15 CTRP2 2.8487 5.458 2.5237 15.7844
Ci-1 CTRP2 2.9575 7.9599 1.6196 18.9533
JJN-3 CTRP2 2.9677 3.932 2.96 13.8608
SU-DHL-4 CTRP2; CTRP1 3.0902 4.6531 3.0061 13.3911
LAMA-84 CTRP2 3.1711 4.5305 3.1139 12.6752
L-428 CTRP2 3.2065 4.2448 3.1875 12.3084
Ki-JK CTRP2 3.244 4.7143 3.1589 12.287
MOLP-2 CTRP2 3.3202 4.5683 3.2681 11.6645
HEL CTRP2 3.3316 4.3968 3.3041 11.5039
TF-1 CTRP2 3.3476 5.1106 3.1741 11.9134
Mono-Mac-1 CTRP2 3.3557 6.1727 2.8056 13.2776
KM-H2 CTRP2 3.3776 4.8432 3.2761 11.4554
Jurkat CTRP2 3.3856 4.4458 3.3555 11.1528
U266B1 CTRP2 3.399 4.4333 3.3713 11.0552
KYO-1 CTRP2 3.4018 4.4709 3.3696 11.0521
HEL 92.1.7 CTRP2 3.4143 5.168 3.2302 11.5082
RL CTRP2 3.4886 4.6235 3.4401 10.5302
EHEB CTRP2 3.4986 4.3091 3.4876 10.3349
SU-DHL-10 CTRP2 3.5134 4.378 3.4977 10.2525
HuNS1 CTRP2 3.5841 5.1888 3.4091 10.3464
JURL-MK1 CTRP2 3.6302 4.4204 3.6164 9.468
HDLM-2 CTRP2 3.6904 4.6863 3.6469 9.1689
OCI-AML-5 CTRP2 3.8813 4.388 3.8783 7.7586
KMS-27 CTRP2 4.1102 4.9085 4.0586 6.4018
Karpas-620 CTRP2 4.1937 5.7803 3.8473 6.9583
A4/Fukuda CTRP2 4.3798 5.3505 4.2174 5.0179
CMK CTRP2 4.3828 8.552 2.7127 11.1507
Mono-Mac-6 CTRP2 4.3912 15.0107 -0.493 22.9577
HD-MY-Z CTRP2 4.4102 4.9959 4.365 4.382
Karpas-422 CTRP2 4.4124 5.0052 4.3649 4.3755
K-562 CTRP2 4.5437 5.0929 4.484 3.5463
RPMI-6666 CTRP2 4.5572 5.0662 4.5066 3.4237
REC-1 CTRP2 6.5031 13.4003 2.011 10.0861
⏷ Show the Full List of 125 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE8 CTRP2 3.5061 4.1121 3.504 10.2555
TE15 CTRP2 4.753 8.1394 3.2478 8.1327
KYSE-140 CTRP2; CTRP1 1.4727 3.9606 1.3811 24.1794
TE-5 CTRP2 1.5647 2.5347 1.5643 23.1835
KYSE-450 CTRP2; CTRP1 2.7933 3.7373 2.7889 15.0936
KYSE-410 CTRP1 3.5296 4.1474 3.5272 21.8624
KYSE-150 CTRP2 3.6952 4.3415 3.6893 9.0082
KYSE-30 CTRP2 3.9803 5.325 3.7959 7.7496
KYSE-510 CTRP2 4.0089 5.1899 3.8715 7.3857
COLO 680N CTRP2 4.4314 5.4642 4.2275 4.8361
EC-GI-10 CTRP2 4.5054 5.192 4.4102 3.9321
TE-1 CTRP2 4.6676 5.6283 4.3999 3.5365
KYSE-70 CTRP2 5.2775 8.9098 3.3024 6.8836
TE-10 CTRP2 5.372 7.4879 2.3432 0.6375
TE-9 CTRP2 5.428 7.8554 3.9443 3.9344
TE-11 CTRP2 5.7241 7.9333 4.1197 2.7543
TE-4 CTRP2 5.7419 7.4633 4.3551 1.7954
TE-6 CTRP2 5.7567 7.4539 4.3689 1.723
KYSE-520 CTRP2 6.0382 13.7154 1.5067 12.8217
KYSE-180 CTRP2 6.5857 11.7489 2.8734 6.531
TE-14 CTRP2 6.7786 8.779 4.348 0.8417
OE21 CTRP2 6.8065 9.3769 4.1105 1.5609
OE19 CTRP2 6.8429 8.2719 4.5734 0.2645
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 36 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
N2a-PK1 CTRP2 4.9881 5.6317 4.7026 1.5493
Panc 03.27 CTRP2; CTRP1 1.1164 1.9051 1.1164 26.2402
Panc 10.05 CTRP2; CTRP1 1.3847 2.5763 1.3835 24.4583
HuP-T4 CTRP2; CTRP1 1.5987 2.6486 1.598 23.0326
KP-3 CTRP2; CTRP1 1.7054 4.218 1.5897 22.7142
PaTu 8902 CTRP2; CTRP1 2.0758 3.4542 2.0722 23.3748
Capan-2 CTRP2; CTRP1 2.1112 6.9139 1.1971 22.9186
QGP-1 CTRP2; CTRP1 2.8532 4.3378 2.8034 14.849
SUIT-2 CTRP2; CTRP1 2.9622 4.5809 2.8813 14.2314
PK-59 CTRP2 3.2671 4.3 3.2461 11.9115
HPAC CTRP2; CTRP1 3.9138 4.7931 3.8705 7.7691
KP-4 CTRP2 3.9214 4.6569 3.8988 7.5581
Panc 08.13 CTRP2 4.2668 5.9745 3.8384 6.8017
PSN1 CTRP2 4.2671 7.9455 2.9042 10.6157
HPAF-II CTRP2 4.3268 7.3307 3.2594 9.0132
HuP-T3 CTRP2 4.4014 5.2271 4.2855 4.6996
PK-45H CTRP2 4.4894 14.2012 -0.0043 21.2196
MIA PaCa-2 CTRP2 4.493 4.9234 4.4708 3.7494
TCC-Pan2 CTRP2 4.4982 5.9424 4.0863 5.2223
SNU-410 CTRP2 4.5941 5.6093 4.3343 3.9851
AsPC-1 CTRP2 4.6291 6.0389 4.1694 4.5666
PaTu 8988t CTRP2 4.6364 5.1754 4.5576 3.0015
SW1990 CTRP2 4.6561 5.964 4.2313 4.2494
PaTu 8988s CTRP2 4.7161 5.2921 4.5976 2.6261
Panc 05.04 CTRP2 4.7238 5.3188 4.5945 2.6176
BxPC-3 CTRP2 4.8479 6.542 4.1261 4.2568
SU.86.86 CTRP2 4.9262 6.4926 4.2196 3.7021
Panc 02.03 CTRP2 4.9878 6.5377 4.2501 3.4494
KP-2 CTRP2 5.116 6.0625 4.5937 1.7607
YAPC CTRP2 5.1395 6.5402 4.3742 2.6389
SNU-213 CTRP2 5.4376 12.9049 1.4368 14.1796
Hs 766T CTRP2 5.5291 8.514 3.6951 4.802
Panc 04.03 CTRP2 5.7731 7.5233 4.3469 1.7877
L3.3 CTRP2 5.8278 7.1597 4.5462 0.98
DAN-G CTRP2 6.1229 7.6709 4.4837 0.9193
CFPAC-1 CTRP2; CTRP1 6.1819 8.2628 4.2678 1.6803
⏷ Show the Full List of 36 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 CTRP2 2.0366 3.9263 1.986 20.2094
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-N-FI CTRP2 1.4306 2.1167 1.4306 24.0756
IMR-32 CTRP2 1.5905 2.0065 1.5905 23.0103
SK-N-SH CTRP2 2.0848 3.8473 2.0457 19.8488
CHP-126 CTRP2 2.0979 3.6391 2.0772 19.6992
SK-N-BE(2) CTRP2 2.6107 4.0701 2.5775 16.3259
KP-N-YN CTRP2 3.0179 5.2852 2.7627 14.4032
NH-6 CTRP2 4.4581 5.6997 4.1554 5.0478
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-478 CTRP2 3.5601 4.1807 3.5572 9.8984
HuCC-T1 CTRP2 3.7797 4.6455 3.7491 8.5294
SNU-1079 CTRP2 3.7964 5.0239 3.688 8.693
HuH-28 CTRP2 4.8945 5.8018 4.5345 2.4516
SNU-869 CTRP2 5.2302 6.7459 4.3431 2.6083
SNU-1196 CTRP2 5.8565 11.2871 2.5713 8.902
SNU-308 CTRP2 6.1764 8.4201 4.1806 1.9404
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 14 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HOS CTRP2 1.6077 2.0457 1.6077 22.8958
A-673 CTRP2 2.0415 3.8381 2.0009 20.1427
SK-ES-1 CTRP2 2.6902 3.916 2.6741 15.7379
G-292 clone A141B1 CTRP2 3.2204 4.1268 3.2106 12.1844
Hs 822.T CTRP2 3.3142 3.7856 3.314 11.5275
Hs 888.T CTRP2 3.7087 4.273 3.7059 8.9078
SaOS-2 CTRP2 3.9257 4.8902 3.862 7.6728
MHH-ES-1 CTRP2 4.0587 5.4126 3.8497 7.3219
SJSA-1 CTRP2 4.2703 5.2166 4.147 5.597
TC71 CTRP2 4.3188 5.0321 4.2559 5.0539
MG-63 CTRP2 4.3697 18.2585 -2.133 27.3484
SK-N-MC CTRP2 4.388 4.8867 4.3642 4.4545
U2OS CTRP1 6.943 10.1587 3.8553 5.0471
SW1353 CTRP2 8.8757 18.0793 1.3762 9.0936
⏷ Show the Full List of 14 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 67 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MCF-7 CTRP2; CTRP1 2.0044 4.0919 1.931 20.5786
T-47D CTRP2 2.8136 3.8215 2.8066 14.8855
DU4475 CTRP2 2.8366 5.035 2.6375 15.405
HCC2218 CTRP2 3.3011 4.5228 3.2548 11.7715
CAL-148 CTRP2 3.3977 5.0618 3.2425 11.514
AU565 CTRP2 3.4609 4.3378 3.4461 10.5994
MDA-MB-361 CTRP2 3.466 4.6357 3.4138 10.6937
Hs 578Bst CTRP2 3.5451 4.9663 3.4289 10.393
MDA-MB-157 CTRP2 3.6197 4.4658 3.6012 9.5539
HCC1954 CTRP2 3.7616 6.2371 3.2039 10.6316
HCC1569 CTRP2 3.7814 4.9722 3.6851 8.7494
HMC-1-8 CTRP2 3.8771 4.4331 3.8722 7.7932
MDA-MB-453 CTRP2 3.8833 5.5187 3.6221 8.6813
HCC1143 CTRP2 3.9299 5.4703 3.69 8.2919
MDA-MB-468 CTRP2 3.9905 5.1283 3.8702 7.4451
ZR-75-1 CTRP2 4.0728 4.8555 4.029 6.6233
CAL-51 CTRP2 4.1209 5.0316 4.04 6.4352
CAL-85-1 CTRP2 4.2427 6.9942 3.3411 8.8734
HCC1500 CTRP2 4.2853 6.3732 3.6755 7.409
KPL-1 CTRP2 4.3148 4.8458 4.2922 4.9377
HCC38 CTRP2 4.4134 5.8328 4.0507 5.5793
HCC1419 CTRP2 4.4455 14.4297 -0.1562 21.8003
BT-549 CTRP2 4.507 15.3951 -0.5853 22.9886
ZR-75-30 CTRP2 4.5606 8.7903 2.7544 10.5951
BT-20 CTRP2 4.5788 5.0804 4.526 3.2878
CAMA-1 CTRP2 4.6165 5.218 4.5207 3.1978
HCC202 CTRP2 4.6904 5.8054 4.3397 3.7244
EFM-192A CTRP2 4.7131 5.7761 4.3758 3.5228
HCC1428 CTRP2 5.3346 6.5267 4.529 1.6665
HCC1937 CTRP2 5.3892 8.7369 3.4771 5.9515
JIMT-1 CTRP2 5.3895 7.2699 4.2046 2.9172
HDQ-P1 CTRP2 6.363 12.0018 2.594 7.9874
HCC1395 CTRP2 6.412 8.6079 4.232 1.5097
HCC1806 CTRP2 9.2516 18.8969 1.2316 9.1285
BT 112 CTRP2 1.9214 2.6378 1.9214 20.8059
BT164 CTRP2 2.1094 3.9969 2.0548 19.7379
BT 239 CTRP2 2.3773 2.9378 2.3773 17.7685
BT 330 CTRP2 2.508 3.3398 2.5071 16.901
BT 248 CTRP2 2.9416 3.8492 2.9365 14.026
BT 231 CTRP2 3.1048 4.4085 3.0613 13.0697
BT 428 CTRP2 3.2314 4.2705 3.2114 12.1459
BT 286 CTRP2 3.2801 4.0058 3.277 11.7642
BT 482 CTRP2 3.3476 4.0571 3.3442 11.3158
BT 245 CTRP2 3.4081 4.4742 3.3759 11.0101
BT 504 CTRP2 3.4476 3.9041 3.4474 10.6387
BT 340 CTRP2 3.4529 3.948 3.4525 10.6039
BT 422 CTRP2 3.4538 3.906 3.4536 10.5976
BT 328 CTRP2 3.4593 3.995 3.4586 10.5626
BT 228 CTRP2 3.4902 3.9835 3.4898 10.3556
BT 333 CTRP2 3.5098 4.0202 3.5092 10.2255
BT 131 CTRP2 3.6158 4.0779 3.6153 9.519
BT 159 CTRP2 3.6285 4.1646 3.627 9.4379
BT 216 CTRP2 3.6419 4.1484 3.6409 9.3471
BT 187 CTRP2 3.7296 5.0498 3.6081 9.1845
BT 145 CTRP2 3.7359 5.0441 3.6165 9.1352
BT 416 CTRP2 3.8618 5.0307 3.7575 8.2429
BT 440 CTRP2 3.871 4.6469 3.8464 7.9007
BT 172 CTRP2 3.9173 4.8703 3.8571 7.7163
BT147 CTRP2 3.9571 4.9499 3.8822 7.5033
BT 232 CTRP2 4.0657 5.0672 3.97 6.8557
BT 139 CTRP2 4.1079 4.7206 4.0891 6.3026
BT 444 CTRP2 4.3274 5.0385 4.2635 4.9998
BT 498 CTRP2 4.4171 5.016 4.3673 4.3526
BT 179 CTRP2 4.4511 9.5331 2.2883 12.7533
BT 359 CTRP2 4.9858 5.7662 4.6335 1.8435
BT 224 CTRP2 5.4418 7.5514 4.1047 3.2457
BT 320 CTRP2 6.736 7.9314 4.6553 0.1582
⏷ Show the Full List of 67 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Tongue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-38 CTRP2 4.329 4.8898 4.2998 4.8663
Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
AM-38 CTRP2 -11.9871 7.6897 -14.3269 73.3016
SNU-466 CTRP2 0.0072 0.96 0.0072 33.5584
Daoy CTRP2 1.9342 3.5222 1.9149 20.7853
SNU-201 CTRP2 1.974 15.6758 -8.5428 21.0611
SF539 CTRP2 2.9682 4.2829 2.932 13.9544
CAS-1 CTRP2 3.0759 4.1536 3.0585 13.173
GB-1 CTRP2 3.1329 4.5822 3.0639 12.9705
KNS-60 CTRP2 3.6507 4.0558 3.6505 9.2858
LN-229 CTRP2; CTRP1 3.786 4.8959 3.7106 8.7322
SF126 CTRP2 3.8979 4.7249 3.8637 7.7547
SNU-738 CTRP2 3.9069 6.1315 3.3997 9.4769
U-87MG ATCC CTRP2 3.9531 4.8764 3.8947 7.4715
SF295 CTRP2; CTRP1 4.0219 5.7189 3.6973 8.0949
GaMG CTRP2; CTRP1 4.1629 5.0563 4.1467 10.1321
8-MG-BA CTRP2 4.181 5.1264 4.0785 6.114
GMS-10 CTRP2 4.3302 4.8463 4.3088 4.831
YH-13 CTRP2 4.4437 4.9732 4.4068 4.1294
SF268 CTRP2 4.4702 5.481 4.2615 4.5989
GOS-3 CTRP2 4.4729 12.6574 0.7517 18.6687
KNS-81 CTRP2 4.5118 5.0441 4.4632 3.7181
U-251MG CTRP2 4.5196 5.6936 4.221 4.6282
DK-MG CTRP2 4.5432 4.9485 4.5203 3.4175
U-118MG CTRP2 4.5461 5.1739 4.4604 3.6264
KALS-1 CTRP2 4.5479 8.7634 2.7564 10.6139
M059K CTRP2 4.6199 4.9707 4.599 2.8999
Becker CTRP2 4.6613 5.1606 4.5897 2.8093
ONS-76 CTRP2 4.7241 5.434 4.5448 2.8131
DBTRG-05MG CTRP2 4.9655 6.8826 4.0587 4.298
Hs 683 CTRP2 4.9883 6.7583 4.1403 3.9101
KG-1-C CTRP2 5.0337 7.0497 4.0328 4.2726
SNU-489 CTRP2 5.0587 10.9975 2.0797 12.3647
42-MG-BA CTRP2 5.4721 7.0569 4.3684 2.1143
SW1088 CTRP2 5.6154 10.8162 2.6194 9.1211
LN-18 CTRP2 5.8334 7.2572 4.5058 1.1193
CCF-STTG1 CTRP2 6.1889 7.8207 4.4541 0.9599
SNB-75 CTRP2 6.9215 11.7236 3.1096 5.1367
NMC-G1 CTRP2 7.0727 8.4277 4.6055 0.1504
T98G CTRP2 8.1069 18.7694 0.5362 13.0202
TM-31 CTRP2 8.7986 18.5325 1.1137 10.1016
SNU-1105 CTRP2 9.1976 18.951 1.1724 9.3963
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HEC-6 CTRP2; CTRP1 0.0297 0.9838 0.0297 33.4726
HEC-151 CTRP2; CTRP1 0.7857 2.5537 0.7778 28.4674
MFE-319 CTRP2; CTRP1 0.9161 2.7163 0.9058 27.6075
JHUEM-2 CTRP2; CTRP1 1.4802 3.7656 1.4156 24.037
JHUEM-1 CTRP2 1.5781 2.1199 1.5781 23.0928
HEC-265 CTRP1 1.6577 2.4919 1.6576 48.5848
KLE CTRP2; CTRP1 1.6677 3.4674 1.6566 25.9959
HEC-251 CTRP2; CTRP1 1.7867 3.2878 1.7755 21.8162
HEC-108 CTRP2; CTRP1 2.0024 3.3996 1.9988 23.8418
HEC-59 CTRP2; CTRP1 2.6584 3.7088 2.6569 19.6601
MFE-296 CTRP2 3.4954 4.4278 3.4739 10.3921
HEC-1-A CTRP2 3.6892 4.7753 3.6293 9.2342
JHUEM-7 CTRP2 4.0573 7.4596 2.9402 10.953
HEC-1-B CTRP2 4.2835 5.5377 4.0417 5.9593
HEC-50B CTRP2 4.2953 5.9097 3.8962 6.4985
ESS-1 CTRP2 4.374 14.7815 -0.3936 22.6927
EFE-184 CTRP2 5.0221 6.5115 4.2922 3.2052
RL95-2 CTRP2 5.0485 9.5547 2.7927 9.4477
EN CTRP2 5.2608 6.5604 4.4583 2.0761
AN3-CA CTRP2 7.9339 16.193 1.6552 9.3258
Ishikawa (Heraklio) 02 ER- CTRP2; CTRP1 1.5713 2.777 1.5707 26.576
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 19 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RCC10RGB CTRP2; CTRP1 1.6127 2.8608 1.6101 22.9456
VMRC-RCW CTRP2; CTRP1 2.3107 3.8207 2.286 18.374
UO-31 CTRP2 3.3877 5.7655 2.9986 12.4489
TUHR14TKB CTRP2 3.4299 4.5039 3.3952 10.8737
TUHR4TKB CTRP2 3.9163 5.2117 3.7638 8.0565
KMRC-2 CTRP2 4.3706 4.8605 4.3499 4.5597
VMRC-RCZ CTRP2 4.4386 13.2675 0.4177 19.9169
ACHN CTRP2 4.4963 9.1371 2.525 11.6825
KMRC-3 CTRP2 4.4975 5.6008 4.239 4.6141
769-P CTRP2 4.9025 6.4352 4.2275 3.718
786-O CTRP2 5.1788 6.4479 4.4513 2.2454
KMRC-1 CTRP2 5.2011 6.6754 4.3556 2.6067
TUHR10TKB CTRP2 5.4506 10.0657 2.8637 8.4027
OS-RC-2 CTRP2 5.5328 6.8314 4.5178 1.4294
BFTC-909 CTRP2 5.5636 6.866 4.5214 1.375
Caki-1 CTRP2 5.6342 8.8044 3.6304 4.8973
KMRC-20 CTRP2 6.2793 8.403 4.2484 1.583
SNU-1272 CTRP2 6.8365 8.3158 4.5546 0.3028
Caki-2 CTRP2 9.445 17.0217 2.2037 5.5727
⏷ Show the Full List of 19 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 49 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LS513 CTRP2; CTRP1 0.1394 1.3225 0.1393 32.7429
SW48 CTRP2; CTRP1 0.1844 1.4661 0.1842 32.4438
SNU-C1 CTRP2 0.6027 3.8715 0.4595 30.0714
SNU-C2A CTRP2; CTRP1 1.2048 3.7898 1.1191 25.9418
GP2d CTRP2; CTRP1 1.2269 2.6554 1.2234 25.5163
COLO205 CTRP2; CTRP1 1.3484 2.1897 1.3484 24.696
DLD-1 CTRP2; CTRP1 1.5351 2.6282 1.5342 23.4564
SNU-C5 CTRP2; CTRP1 1.6324 3.6457 1.5899 22.9487
LS180 CTRP2; CTRP1 1.6751 3.1234 1.6674 22.5472
CL-34 CTRP1 1.8632 4.4682 1.713 46.0886
SK-CO-1 CTRP2; CTRP1 2.0398 3.1942 2.0365 20.1053
CW-2 CTRP2; CTRP1 2.078 3.7817 2.0455 19.9492
C2BBe1 CTRP2; CTRP1 2.1752 4.0106 2.1239 19.3666
RCM-1 [Human ESC] CTRP2; CTRP1 2.2436 3.3275 2.2404 18.7484
RKO CTRP2; CTRP1 2.2778 4.0158 2.2321 18.6644
SNU-175 CTRP1 2.3179 3.529 2.3103 39.2081
COLO 678 CTRP2; CTRP1 2.4127 4.7267 2.2545 18.1582
SW480 CTRP1 2.4247 4.1915 2.3662 38.0063
SW403 CTRP1 2.4382 4.2357 2.3742 37.8466
HT-55 CTRP2; CTRP1 2.4573 4.0956 2.4131 17.4647
HCT 116 CTRP2; CTRP1 2.5246 4.3846 2.4438 17.1427
SNU-61 CTRP2; CTRP1 2.577 3.685 2.5697 16.543
SNU-81 CTRP1 2.6729 4.0905 2.6417 34.3042
SNU-C4 CTRP2; CTRP1 2.6791 3.8786 2.6653 15.8855
COLO 320 CTRP2; CTRP1 2.7979 5.077 2.5837 15.7168
SW948 CTRP2; CTRP1 2.8588 4.2584 2.8197 14.7754
SNU-1040 CTRP1 2.9614 4.5408 2.8876 30.4937
CL-40 CTRP1 3.1055 4.1032 3.0934 27.9928
HT115 CTRP2; CTRP1 3.2982 4.3712 3.2723 11.8059
KM12 CTRP2; CTRP1 3.3513 5.005 3.2097 11.8585
LS123 CTRP2; CTRP1 3.368 4.4625 3.3356 11.3637
SNU-1033 CTRP2 3.3702 4.4585 3.3376 11.2642
T84 CTRP2 3.4133 4.7736 3.3303 11.1522
NCI-H747 CTRP2 3.6462 4.8436 3.5683 9.5835
SNU-407 CTRP2 3.6886 4.7039 3.6419 9.1917
MDST8 CTRP2; CTRP1 3.7304 4.8594 3.6582 9.0906
SW620 CTRP2; CTRP1 3.7553 6.4501 3.1111 11.0982
OUMS-23 CTRP2 3.7761 4.2571 3.7747 8.4542
LoVo CTRP2; CTRP1 3.8134 4.995 3.7166 8.6262
NCI-H508 CTRP2; CTRP1 3.9328 6.9042 3.0865 10.7445
HCT 8 CTRP2; CTRP1 4.0002 5.5562 3.7378 8
LS1034 CTRP2 4.4737 5.0245 4.4269 3.9654
LS411N CTRP2; CTRP1 4.5427 5.419 4.3683 4.0788
SW1417 CTRP2 4.6599 10.9588 1.761 14.446
HCT 15 CTRP2 4.6724 5.2608 4.5641 2.8754
HT-29 CTRP2; CTRP1 4.8645 5.5985 4.6139 2.2806
NCI-H716 CTRP2 4.8963 5.963 4.4566 2.7724
HCC-56 CTRP2 5.2086 6.4716 4.4626 2.1462
SNU-503 CTRP2 5.9741 8.3467 4.0888 2.5367
⏷ Show the Full List of 49 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 20 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-182 CTRP2 0.6591 3.0464 0.6213 29.342
JHH-2 CTRP2 2.103 3.7463 2.0742 19.6927
SNU-449 CTRP2; CTRP1 2.3015 3.7225 2.2953 21.9465
SNU-761 CTRP2 2.7226 3.5451 2.7211 15.4734
SNU-398 CTRP2; CTRP1 2.7398 6.8707 1.8768 18.6192
Hep 3B2.1-7 CTRP2 3.6262 4.1197 3.6254 9.4508
Hep-G2 CTRP2; CTRP1 3.8579 5.4739 3.6153 8.8672
JHH-6 CTRP2; CTRP1 4.0337 5.0568 4.0108 10.9763
JHH-5 CTRP2 4.2641 9.514 2.13 13.8032
SNU-423 CTRP2 4.4076 8.4837 2.769 10.8636
HLF CTRP2 4.4328 4.9116 4.4079 4.1597
JHH-4 CTRP2 4.515 6.9786 3.6071 7.1474
SK-HEP-1 CTRP2 4.5466 4.9362 4.5264 3.3854
SNU-387 CTRP2 4.6576 5.246 4.5541 2.9547
JHH-1 CTRP2 4.664 5.091 4.6157 2.7052
SNU-886 CTRP2 4.8394 21.1264 -3.168 28.6335
Li-7 CTRP2 5.091 6.698 4.2562 3.2243
SNU-878 CTRP2 5.2815 7.9322 3.793 4.8197
SNU-475 CTRP2 6.3974 10.6326 3.2816 5.1667
HuH-1 CTRP2 6.8882 8.4016 4.5437 0.3053
⏷ Show the Full List of 20 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 151 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCC33 CTRP1 -0.9678 1.0046 -0.97 82.3721
NCI-H1963 CTRP1 -0.6553 0.7263 -0.6555 80.5399
NCI-H810 CTRP2; CTRP1 -0.1504 1.0346 -0.1504 34.6716
NCI-H82 CTRP1 -0.0822 1.4389 -0.083 72.7928
NCI-H1568 CTRP2; CTRP1 0.0452 1.9284 0.0403 33.3857
NCI-H1299 CTRP2; CTRP1 0.1415 1.1993 0.1414 32.729
NCI-H1048 CTRP1 0.3812 1.3817 0.3812 66.7803
NCI-H2029 CTRP2; CTRP1 0.4235 1.4263 0.4234 30.8522
SHP-77 CTRP2; CTRP1 0.5812 1.4539 0.5812 29.8023
SCLC-21H CTRP1 0.6193 2.6556 0.6041 62.7216
NCI-H1666 CTRP1 0.6487 2.265 0.6451 62.7183
NCI-H23 CTRP1 0.6714 2.4979 0.663 62.233
COR-L51 CTRP1 0.8718 2.6891 0.8614 59.5025
COR-L88 CTRP1 0.9212 2.0991 0.9207 59.0732
NCI-H2141 CTRP1 0.9555 3.2006 0.9193 58.0473
NCI-H2106 CTRP2 1.0708 2.3344 1.0696 26.4766
NCI-H1694 CTRP2; CTRP1 1.1817 2.6606 1.1775 25.8194
NCI-H1876 CTRP1 1.2427 2.5281 1.241 54.4931
NCI-H526 CTRP2 1.2989 2.6597 1.296 24.9626
NCI-H727 CTRP2; CTRP1 1.3099 3.3613 1.2769 25.063
HCC1359 CTRP1 1.3853 2.7265 1.3823 52.4641
NCI-H2286 CTRP1 1.4871 2.6244 1.4868 55.3972
NCI-H1781 CTRP1 1.4912 3.5985 1.4457 50.9187
NCI-H1105 CTRP2; CTRP1 1.5532 3.228 1.538 23.3836
NCI-H522 CTRP2; CTRP1 1.5788 2.9389 1.5743 23.1775
Calu-6 CTRP2; CTRP1 1.5861 3.058 1.5787 23.1386
NCI-H211 CTRP2 1.5915 2.7637 1.5898 23.0092
COLO 668 CTRP2; CTRP1 1.6679 2.93 1.667 25.9622
COLO 699 CTRP2; CTRP1 1.668 3.573 1.634 22.683
NCI-H1975 CTRP1 1.6878 3.8933 1.6203 48.2642
NCI-H1836 CTRP1 1.7 2.6215 1.6997 47.9851
COR-L95 CTRP2 1.7187 2.4525 1.7187 22.1562
HCC78 CTRP2; CTRP1 1.7584 2.9677 1.7557 21.9761
LCLC-97TM1 CTRP1 1.774 3.7698 1.7265 47.0524
NCI-H2405 CTRP2; CTRP1 1.8076 3.1579 1.8014 21.6603
NCI-H841 CTRP2; CTRP1 1.8805 2.8238 1.88 21.1563
NCI-H3255 CTRP1 1.888 3.2343 1.8811 45.3313
ChaGo-K-1 CTRP2; CTRP1 1.9511 3.4473 1.9371 20.7315
COR-L279 CTRP1 1.9696 3.5054 1.953 44.2118
LCLC-103H CTRP2; CTRP1 1.9967 2.889 1.9963 20.3824
NCI-H2342 CTRP2; CTRP1 2.0554 4.1005 1.9843 20.2314
Lu-99 CTRP2; CTRP1 2.0646 3.0723 2.0632 19.9338
NCI-H2196 CTRP2 2.0697 3.7793 2.0364 19.9302
NCI-H1435 CTRP2; CTRP1 2.0865 3.6885 2.077 23.3254
DMS 273 CTRP2; CTRP1 2.0923 4.1104 2.0224 19.9819
NCI-H650 CTRP2; CTRP1 2.1875 3.8312 2.1559 19.2173
HCC2108 CTRP2; CTRP1 2.2308 3.9645 2.1882 18.9664
DMS 79 CTRP2 2.3056 6.1176 1.7064 20.4042
COR-L23 CTRP1 2.3125 3.5009 2.3058 39.2795
SK-LU-1 CTRP2; CTRP1 2.3253 4.6519 2.1761 18.7078
RERF-LC-KJ CTRP1 2.3901 3.9393 2.3781 43.7179
NCI-H446 CTRP2 2.4061 3.2384 2.4054 17.5789
NCI-H358 CTRP2; CTRP1 2.5063 3.7863 2.4919 17.0372
NCI-H1930 CTRP1 2.5305 3.595 2.5292 41.8404
NCI-H441 CTRP1 2.6155 4.4156 2.5365 35.4387
NCI-H2081 CTRP2; CTRP1 2.6192 4.9545 2.4241 16.9167
KNS-62 CTRP2; CTRP1 2.7563 3.7294 2.7514 15.3419
NCI-H2009 CTRP2; CTRP1 2.7641 4.6271 2.6579 15.638
NCI-H1184 CTRP2 2.7971 4.3106 2.7462 15.1445
DMS 53 CTRP2 2.8017 3.9686 2.7864 14.9923
A-549 CTRP2; CTRP1 2.827 6.6771 2.0482 17.7241
NCI-H596 CTRP1 2.8349 4.2608 2.7941 32.0615
NCI-H1373 CTRP2; CTRP1 2.8805 7.3231 1.8304 18.4184
NCI-H2073 CTRP1 2.967 4.8732 2.8239 30.9051
HCC1833 CTRP2; CTRP1 2.9743 5.8046 2.5442 15.4243
EPLC-272H CTRP2; CTRP1 3.0493 4.778 2.9356 13.7671
NCI-H2126 CTRP2; CTRP1 3.0721 4.3817 3.031 13.3626
HARA [Human squamous cell lung carcinoma] CTRP2; CTRP1 3.1516 6.3658 2.5172 15.0314
EBC-1 CTRP2; CTRP1 3.1651 8.3082 1.6744 18.2852
HCC4006 CTRP2; CTRP1 3.179 4.6947 3.0941 12.803
NCI-H1581 CTRP2 3.1982 4.1356 3.187 12.3372
SBC-5 CTRP2 3.2527 4.4148 3.2181 12.0538
NCI-H1755 CTRP2; CTRP1 3.2591 5.1188 3.0781 12.6134
NCI-H1155 CTRP2 3.3224 4.4272 3.2907 11.5794
HOP-92 CTRP2 3.3318 4.6561 3.2653 11.6374
DMS 454 CTRP2 3.3402 4.7679 3.2521 11.6572
LC-1/sq-SF CTRP2; CTRP1 3.3599 4.6098 3.3052 11.4945
HCC827 CTRP2; CTRP1 3.4262 4.5215 3.3899 10.9897
RERF-LC-A1 CTRP2 3.4407 4.77 3.3608 10.959
NCI-H1944 CTRP2; CTRP1 3.4544 5.1072 3.2945 11.2393
HCC15 CTRP2; CTRP1 3.4603 7.045 2.5466 14.0976
NCI-H1437 CTRP1 3.4819 4.4038 3.4628 22.6645
NCI-H1915 CTRP2; CTRP1 3.5406 4.9767 3.4974 14.1803
NCI-H2122 CTRP2; CTRP1 3.5578 4.4623 3.5369 10.061
DMS 114 CTRP2 3.5618 4.4964 3.5365 9.9626
NCI-H1734 CTRP2 3.599 4.4298 3.5829 9.6836
NCI-H1355 CTRP1 3.6139 5.346 3.3951 22.3026
NCI-H1573 CTRP2; CTRP1 3.6244 4.688 3.5768 9.7097
NCI-H520 CTRP2 3.6943 4.5646 3.669 9.0802
HCC2279 CTRP2 3.7006 4.5618 3.6759 9.0362
BEN CTRP2; CTRP1 3.7223 4.5547 3.7006 8.9691
CAL-12T CTRP2; CTRP1 3.7234 5.8878 3.3139 10.3918
Calu-3 CTRP2; CTRP1 3.7528 4.3753 3.7472 8.7119
NCI-H2085 CTRP2 3.8206 5.0383 3.7105 8.538
DV-90 CTRP1 3.9544 5.4959 3.7112 17.6619
NCI-H460 CTRP2; CTRP1 3.9613 5.1375 3.8387 7.7367
SW1271 CTRP2 4.0381 5.0844 3.9351 7.0657
LXF 289 CTRP2; CTRP1 4.0759 6.9261 3.506 12.6448
Sq-1 CTRP2; CTRP1 4.1768 5.118 4.0794 6.2134
NCI-H1563 CTRP2 4.2064 5.7846 3.8587 6.8798
Calu-1 CTRP2 4.2106 6.5899 3.5008 8.2997
HCC1195 CTRP2; CTRP1 4.2262 6.4702 3.5788 8.0323
RERF-LC-Ad2 CTRP2 4.251 9.2546 2.2463 13.3586
COR-L105 CTRP2 4.266 5.4388 4.0621 5.9297
NCI-H1341 CTRP2 4.2671 5.8515 3.8927 6.5857
IA-LM CTRP2 4.2832 5.6816 3.9822 6.1914
NCI-H2444 CTRP2 4.2837 5.0157 4.2219 5.283
NCI-H292 CTRP2 4.2917 5.0296 4.2269 5.2407
VMRC-LCD CTRP2; CTRP1 4.3013 5.4148 4.1135 5.7249
NCI-H1650 CTRP2 4.347 5.3777 4.1719 5.2835
NCI-H2291 CTRP2 4.3844 5.579 4.1309 5.3388
HCC2935 CTRP2; CTRP1 4.4161 5.7002 4.1179 5.3959
HCC1588 CTRP2 4.4445 4.9995 4.4014 4.1463
NCI-H1703 CTRP2 4.4586 11.4338 1.3493 16.4768
RERF-LC-MS CTRP2 4.4924 5.3898 4.322 4.3039
SK-MES-1 CTRP2 4.5681 5.1927 4.4777 3.4979
NCI-H2172 CTRP1 4.5899 5.4298 4.4135 8.1033
NCI-H1838 CTRP2 4.6266 5.9749 4.1975 4.4578
Lu-65 CTRP2; CTRP1 4.6313 6.5944 3.911 5.7137
NCI-H1869 CTRP2 4.6704 5.681 4.3784 3.6163
NCI-H196 CTRP2 4.6733 5.678 4.3827 3.5916
HCC44 CTRP2; CTRP1 4.677 8.0612 3.2288 8.4539
EKVX CTRP2 4.6907 7.2513 3.6339 6.6485
RERF-LC-Ad1 CTRP2 4.7464 5.0793 4.709 2.1175
NCI-H1793 CTRP2; CTRP1 4.9091 7.0055 3.9581 4.9196
NCI-H661 CTRP2; CTRP1 4.9431 7.7853 3.598 6.3615
T3M-10 CTRP2; CTRP1 4.9876 10.6935 2.1819 12.1651
NCI-H1339 CTRP2 5.0007 6.0469 4.5063 2.3479
HCC366 CTRP2 5.0152 6.3607 4.3618 2.926
NCI-H838 CTRP2 5.2637 6.5981 4.4419 2.1396
NCI-H2228 CTRP2 5.274 7.1841 4.1594 3.2999
NCI-H226 CTRP2 5.3527 6.7934 4.4116 2.1208
LK2 CTRP2 5.4679 7.0512 4.3683 2.1209
HCC1171 CTRP2 5.5008 13.2978 1.2916 14.6147
PC-14 CTRP2 5.5651 7.3786 4.2776 2.3461
NCI-H2170 CTRP2 5.5925 7.4045 4.284 2.2805
LUDLU-1 CTRP2 5.6598 8.2952 3.899 3.7487
HOP-62 CTRP2 5.683 8.3417 3.8929 3.7379
NCI-H647 CTRP2 5.9103 8.4085 4.0177 2.9024
MOR/CPR CTRP2 6.0847 7.7628 4.423 1.1601
NCI-H2030 CTRP2; CTRP1 6.194 9.7099 3.5979 4.2604
HCC95 CTRP2 6.2232 9.1924 3.8513 3.1438
NCI-H2023 CTRP2; CTRP1 6.3399 8.89 4.0763 2.2124
NCI-H1792 CTRP2; CTRP1 6.5195 11.3093 3.0512 5.9882
NCI-H2110 CTRP2; CTRP1 6.5977 12.8742 2.3476 8.6811
NCI-H1651 CTRP2 6.6725 9.2528 4.0921 1.7455
HCC1438 CTRP2 7.2245 14.5003 1.9869 9.081
NCI-H322 CTRP2 7.7393 8.9703 4.6538 0.0303
LOU-NH91 CTRP2 7.807 16.2235 1.5558 9.8653
NCI-H1623 CTRP2 7.8444 16.1085 1.6359 9.5198
Hs 888.Lu CTRP2 5.1886 7.2711 4.0488 3.9146
⏷ Show the Full List of 151 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Thigh Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
P-STS CTRP2 1.3519 2.2838 1.3518 24.6004
H-STS CTRP2 1.9453 3.4094 1.9327 20.6891
SYO-1 CTRP2 4.0751 16.6702 -1.5948 26.6731
Cancer Drug Sensitivity Data Curated from 44 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
2004 CTRP2 1.8989 4.1875 1.8019 21.286
OVCAR-8 CTRP2; CTRP1 -0.267 1.6169 -0.2705 35.4591
OVCAR-4 CTRP2; CTRP1 -0.0557 1.1153 -0.0558 34.0416
HEY A8 CTRP2; CTRP1 -0.0182 0.9414 -0.0182 33.7918
OVK18 CTRP2; CTRP1 0.0248 1.4459 0.0242 33.5075
JHOS-4 CTRP1 0.8556 2.2466 0.855 63.5227
COV434 CTRP2; CTRP1 0.8976 2.3321 0.8954 27.7035
OVKATE CTRP1 1.078 2.8571 1.0662 56.6797
RMUG-S CTRP1 1.2283 3.4681 1.1818 54.4227
A2780 CTRP1 2.13 3.3156 2.1253 41.8704
TYK-nu CTRP2; CTRP1 2.1775 4.0386 2.1229 19.3622
COV318 CTRP1 2.2788 3.5768 2.2755 45.122
JHOC-5 CTRP2; CTRP1 2.4163 3.5207 2.4111 17.6055
EFO-27 CTRP2; CTRP1 2.6166 3.7841 2.606 16.2905
RMG-I CTRP2; CTRP1 2.7143 4.3839 2.6479 15.8307
COV644 CTRP2; CTRP1 2.7576 4.6168 2.6529 15.676
OV-90 CTRP2; CTRP1 2.8149 4.1438 2.786 15.0329
SK-OV-3 CTRP2; CTRP1 3.0129 12.1594 -0.3134 25.6418
Caov-3 CTRP2; CTRP1 3.0671 3.9193 3.0626 13.2718
EFO-21 CTRP2; CTRP1 3.1905 4.5837 3.1272 12.6514
IGROV-1 CTRP2; CTRP1 3.2183 4.861 3.1005 12.6578
OC 314 CTRP2 3.2756 4.0287 3.2717 11.7968
OVMANA CTRP1 3.277 4.4857 3.2648 32.2027
OVSAHO CTRP2 3.3856 3.9603 3.3847 11.054
ES2 CTRP2 3.5494 4.2651 3.5428 9.9821
DOV13 CTRP2 3.6708 4.2588 3.6677 9.1614
SNU-119 CTRP2 3.6994 4.5801 3.6723 9.0522
FU-OV-1 CTRP2 3.7264 4.758 3.6728 8.9644
ONCO-DG-1 CTRP2 3.7527 4.6924 3.7129 8.7411
OVISE CTRP2 3.904 4.5906 3.8882 7.6508
OV7 CTRP2; CTRP1 3.9684 5.1795 3.8338 7.7334
TOV-112D CTRP2 3.9702 5.7878 3.6098 8.4867
OAW28 CTRP2 4.0913 5.6561 3.791 7.4547
OVCAR-5 CTRP2 4.143 5.0662 4.0546 6.3151
OAW42 CTRP2; CTRP1 4.1893 4.9179 4.1443 5.9426
SNU-8 CTRP2 4.2171 4.8406 4.1879 5.6115
JHOM-1 CTRP2; CTRP1 4.2993 7.1515 3.3276 8.8807
TOV-21G CTRP2 4.5128 5.0159 4.4718 3.6842
JHOS-2 CTRP2 4.56 5.0219 4.5217 3.3604
Kuramochi CTRP2 4.5867 5.9475 4.1715 4.6599
OV56 CTRP2 4.7242 5.1685 4.6546 2.3847
COV362 CTRP2; CTRP1 4.8144 6.1261 4.31 3.6501
SNU-840 CTRP2; CTRP1 4.8206 5.5491 4.5949 2.4623
OVTOKO CTRP2 6.3227 11.8058 2.6608 7.7807
⏷ Show the Full List of 44 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Aska-SS CTRP2 3.5283 4.5255 3.4972 10.206
Yamato-SS CTRP2 3.9309 4.5856 3.917 7.4652
G-401 CTRP2; CTRP1 -0.4038 1.2474 -0.4049 36.3618
TE 441.T CTRP2 1.7528 4.012 1.6724 22.202
GCT CTRP2 2.1971 3.4943 2.1876 19.0009
TTC-709 CTRP2 2.2908 3.126 2.2903 18.3467
A-204 CTRP2 2.8827 22.0707 -5.3311 35.9455
KYM-1 CTRP2 3.184 4.2511 3.1634 12.4638
Tm87-16 CTRP2 3.2248 4.168 3.2126 12.1633
RKN CTRP2; CTRP1 3.2331 4.6335 3.1643 12.3872
Rh41 CTRP2 3.4888 4.0257 3.4879 10.3666
HT-1080 CTRP2; CTRP1 3.813 6.309 3.2318 10.4711
TE 617.T CTRP2 4.0176 5.5665 3.7479 7.8247
SK-LMS-1 CTRP2 4.1706 5.414 3.9694 6.5507
BT-12 CTRP2 4.3249 4.8308 4.3055 4.8596
G-402 CTRP2 4.3276 5.6694 4.0336 5.8715
SW982 CTRP2 4.4276 12.8195 0.6316 19.1936
SK-UT-1 CTRP2 4.4304 18.8967 -2.3998 27.8279
Hs 729.T CTRP2 4.4779 4.9224 4.4547 3.8534
RD CTRP2 4.482 16.8616 -1.3391 25.1543
MES-SA CTRP2 4.8466 6.7399 4.0267 4.6755
BT-16 CTRP2 6.2655 7.6621 4.5589 0.5788
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Clivus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U-CH1 CTRP2 4.5581 5.1447 4.4832 3.5068
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MSTO-211H CTRP1 1.5194 2.9236 1.5144 50.5553
NCI-H2052 CTRP2; CTRP1 2.1017 3.4452 2.092 19.7145
NCI-H28 CTRP2; CTRP1 3.0413 5.1254 2.8385 14.1395
IST-Mes1 CTRP2 4.5579 5.0908 4.5001 3.4449
NCI-H2452 CTRP2 4.6703 6.0197 4.2182 4.2692
JL-1 CTRP2 5.8804 10.7231 2.8681 7.6444
ACC-MESO-1 CTRP2 6.0608 8.7074 3.9748 2.8708
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PaCa-3 CTRP2; CTRP1 0.6944 2.4492 0.6916 32.1638
VCaP CTRP2 2.9158 6.2643 2.3032 16.4233
22Rv1 CTRP2 3.6794 4.8171 3.6101 9.3326
DU145 CTRP2 4.7337 6.3447 4.1201 4.5295
LNCaP clone FGC CTRP2 5.1647 6.9632 4.1833 3.3938
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 CTRP2 4.3215 10.7474 1.5701 15.9151
YD-15 CTRP2 5.4534 6.6007 4.575 1.3091
Cancer Drug Sensitivity Data Curated from 47 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Hs 852.T CTRP2; CTRP1 0.5525 2.3876 0.5491 33.0687
G-361 CTRP2; CTRP1 1.1858 3.2589 1.1552 25.8807
UACC-62 CTRP2 1.4333 3.1177 1.4196 24.1037
WT2-iPS CTRP2 1.5451 1.9488 1.5451 23.3131
SK-MEL-5 CTRP2; CTRP1 1.5875 2.9777 1.5822 23.1222
Hs 936.T CTRP2; CTRP1 1.6306 2.6009 1.6302 22.8191
COLO 741 CTRP1 2.4805 3.4912 2.4771 36.855
A-375 CTRP2; CTRP1 2.528 5.0605 2.2964 17.6538
Hs 934.T CTRP2 2.9685 3.8789 2.9631 13.848
MDA-MB-435S CTRP2 3.2037 3.9994 3.1992 12.278
WM266-4 CTRP2 3.2062 4.6471 3.1311 12.5038
COLO 792 CTRP2 3.2491 7.4075 2.1636 16.076
Hs 944.T CTRP2; CTRP1 3.2523 6.7749 2.4513 15.0167
SK-MEL-3 CTRP2 3.2686 5.1913 3.0643 12.5507
Hs 688(A).T CTRP2 3.517 3.9741 3.5167 10.1765
Hs 294T CTRP2 3.5488 4.6625 3.4983 10.1362
RPMI-7951 CTRP2 3.6795 4.3022 3.675 9.1081
WM115 CTRP2 3.7991 6.6899 3.0433 11.1705
SK-MEL-1 CTRP2; CTRP1 3.8659 4.9695 3.7803 8.2371
HMCB CTRP2 3.9053 4.5381 3.8944 7.6255
Mel Ho CTRP2 4.0322 4.8922 3.9773 6.9328
SK-MEL-28 CTRP2; CTRP1 4.0382 4.3845 4.0378 6.7947
SK-MEL-30 CTRP2 4.1243 4.8191 4.0916 6.2414
RVH-421 CTRP2 4.133 5.3748 3.9434 6.756
MeWo CTRP2 4.1783 4.9333 4.1271 5.9469
CJM [Human melanoma] CTRP2 4.2846 4.9449 4.2401 5.2158
LOX-IMVI CTRP2 4.3366 5.4104 4.1484 5.4024
UACC-257 CTRP2 4.3704 4.8733 4.3475 4.5682
WM1799 CTRP2 4.4466 5.0026 4.4029 4.1344
Hs 839.T CTRP2 4.4488 4.8911 4.4289 4.036
IGR-1 CTRP2 4.4522 5.0434 4.3984 4.1334
IPC-298 CTRP2 4.4927 4.874 4.4789 3.7224
SK-MEL-2 CTRP2 4.5097 5.0407 4.4619 3.7295
A101D CTRP2 4.5168 11.2515 1.4909 15.8068
HT-144 CTRP2 4.6769 11.2416 1.6345 14.9108
COLO 800 CTRP2 4.7265 5.477 4.5279 2.8743
Hs 895.T CTRP2 4.8339 6.6791 4.0457 4.6227
IGR-39 CTRP2 5.005 6.7077 4.1797 3.7114
COLO 829 CTRP2 5.0145 6.464 4.3095 3.1469
WM793 CTRP2 5.2226 6.5498 4.4345 2.2394
SK-MEL-31 CTRP2 5.2394 6.6426 4.4014 2.3489
Mel JuSo CTRP2 5.4482 8.8511 3.4662 5.8936
WM88 CTRP2 5.9099 13.3495 1.5893 12.7296
A2058 CTRP2 6.1494 10.1862 3.326 5.3465
WM983B CTRP2 6.4571 15.3231 1.0296 13.8822
K029AX CTRP2 6.4995 14.6403 1.3986 12.4467
IGR-37 CTRP2 6.5115 7.8865 4.5813 0.3819
⏷ Show the Full List of 47 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
AGS CTRP2; CTRP1 -0.0362 1.1415 -0.0363 33.9118
MKN7 CTRP2; CTRP1 1.4787 3.1459 1.4653 23.8736
ECC10 CTRP2 2.066 4.0673 1.9993 20.0688
Fu97 CTRP2; CTRP1 2.2752 3.313 2.2726 18.5361
MKN74 CTRP2; CTRP1 3.0771 4.4935 3.0569 17.0553
HGC-27 CTRP2 3.1996 4.0454 3.1933 12.3113
SNU-216 CTRP2 3.2048 4.1953 3.1898 12.306
MKN1 CTRP2 3.4346 4.2181 3.4269 10.7506
GSS CTRP2 3.4558 4.4211 3.4328 10.661
KE-39 CTRP2 3.6069 4.792 3.5366 9.8185
SNU-601 CTRP2 3.8456 4.7555 3.8021 8.1353
SH-10-TC CTRP2; CTRP1 3.9975 5.9576 3.5734 8.6416
NCI-N87 CTRP2 4.3264 5.5417 4.0854 5.6728
NUGC-3 CTRP2 4.3887 5.0916 4.3154 4.6265
GSU CTRP2 4.4257 4.8071 4.4162 4.1539
SNU-1 CTRP2 4.4913 5.3054 4.3538 4.1849
SNU-16 CTRP2 4.5393 4.9986 4.505 3.4839
Hs 746.T CTRP2 4.5592 5.0164 4.5223 3.3609
LMSU CTRP2 4.5688 4.945 4.5487 3.2374
SNU-5 CTRP2 4.7984 6.2509 4.2256 3.9478
SNU-719 CTRP2 4.8421 5.8408 4.4672 2.8472
HuG1-N CTRP2 5.147 8.3471 3.4778 6.3893
IM95 CTRP2 5.5986 9.054 3.4807 5.577
SNU-668 CTRP2 5.8158 10.0257 3.1638 6.5316
NUGC-4 CTRP2; CTRP1 6.0042 8.0018 4.2807 1.8318
ECC12 CTRP2 6.016 8.0185 4.2679 1.7967
MKN45 CTRP2 6.293 7.3868 4.6795 0.2596
SNU-620 CTRP2 6.573 7.7285 4.6657 0.1864
23132/87 CTRP2 9.2316 21.4488 0.0146 13.14
SNG-M CTRP1 1.1197 2.7119 1.1172 60.0621
SNU-1077 CTRP2 4.1766 7.3484 3.1081 9.9844
SNU-685 CTRP2 4.3932 10.0599 1.9752 14.1499
⏷ Show the Full List of 32 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 12 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
8505C CTRP2 2.444 3.863 2.4213 17.4005
CAL-62 CTRP2 3.5964 4.1281 3.5952 9.6507
B-CPAP CTRP2 4.0436 5.0016 3.9635 6.9466
FTC-238 CTRP2 4.1074 5.3733 3.9163 6.9313
FTC-133 CTRP2 4.3733 4.982 4.3281 4.6276
8305C CTRP2 4.4771 5.0129 4.4336 3.931
SW579 CTRP2 4.7021 5.4006 4.537 2.9011
BHT-101 CTRP2 5.0626 6.1938 4.4847 2.3176
TT CTRP2 5.3894 9.2645 3.2146 7.0489
ML-1 [Human leukemia] CTRP2 5.6912 7.1913 4.4502 1.4905
TT2609-C02 CTRP2 5.9295 10.1454 3.1887 6.2456
CGTH-W-1 CTRP2 6.1653 9.3238 3.7513 3.6142
⏷ Show the Full List of 12 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HSC-2 CTRP2; CTRP1 0.61 1.8655 0.6096 29.6119
SCC-9 CTRP2; CTRP1 2.7295 4.875 2.5646 16.0756
SCC-4 CTRP2 3.1038 24.7263 -6.4571 36.8153
YD-8 CTRP2 3.5919 4.2346 3.5879 9.6901
SNU-46 CTRP2 3.8 4.6785 3.7659 8.4063
FaDu CTRP2 3.9774 4.8265 3.9313 7.2666
HSC-4 CTRP2 3.9846 4.6835 3.9626 7.1351
HSC-3 CTRP2 4.14 5.0089 4.0669 6.2801
SNU-1214 CTRP2 4.3588 5.241 4.2346 5.0131
SNU-1076 CTRP2 4.3906 4.8429 4.374 4.4121
SNU-899 CTRP2 4.4091 6.1978 3.8796 6.2782
BICR 6 CTRP2 4.4411 4.9067 4.4178 4.0991
PE/CA-PJ34 (clone C12) CTRP2 4.5434 4.9234 4.5253 3.3993
PE/CA-PJ15 CTRP2 4.5822 5.9894 4.1474 4.7689
CAL-27 CTRP2 4.6422 5.0658 4.5994 2.8298
BICR 31 CTRP2 4.7745 5.5352 4.5491 2.669
BHY CTRP2 4.8975 7.5822 3.6511 6.1462
PE/CA-PJ41 (clone D2) CTRP2 4.9187 5.6414 4.6356 1.9772
Detroit 562 CTRP2 4.9842 6.2623 4.3846 2.8918
BICR 18 CTRP2 5.2403 6.7714 4.3382 2.611
SNU-1041 CTRP2 5.8493 7.7077 4.3088 1.8397
SNU-1066 CTRP2 6.2384 8.1735 4.3272 1.3455
BICR 16 CTRP2 6.2929 7.8584 4.4913 0.7588
CAL-33 CTRP2 6.6462 12.3567 2.6218 7.4464
BICR 22 CTRP2 6.9743 8.4459 4.5617 0.2433
BICR 56 CTRP2 7.0606 8.3795 4.618 0.1367
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KMBC-2 CTRP2; CTRP1 0.8675 2.0374 0.8671 27.8978
RT-4 CTRP2; CTRP1 1.2747 2.771 1.2695 25.204
UM-UC-3 CTRP2; CTRP1 1.7007 2.9917 1.6969 22.3639
HT-1376 CTRP2; CTRP1 1.8903 3.2964 1.8813 21.1193
5637 CTRP2; CTRP1 2.0222 7.4246 0.895 24.2643
HT-1197 CTRP2 2.8908 4.9694 2.7141 14.9636
BFTC-905 CTRP2 3.526 4.2607 3.519 10.1392
U-BLC1 CTRP2 3.7201 4.3834 3.7127 8.8473
KU-19-19 CTRP2 3.875 4.4796 3.8673 7.8164
CAL-29 CTRP2 3.8882 4.8454 3.8308 7.9001
TCCSUP CTRP2 3.9433 4.8902 3.881 7.5505
JMSU-1 CTRP2 4.1626 5.1625 4.0474 6.2826
SCaBER CTRP2 4.412 4.9486 4.3779 4.3306
647V CTRP2 4.4295 4.9452 4.3976 4.2062
639V CTRP2 4.6501 5.0079 4.6235 2.7189
UM-UC-1 CTRP2 4.7308 5.5997 4.476 3.0725
253J-BV CTRP2 4.7668 5.7028 4.4626 3.0401
T24 CTRP2 4.8074 6.81 3.957 5.0496
J82 CTRP2 4.8837 14.7309 0.0666 20.1686
BC-3C CTRP2 5.1153 6.954 4.148 3.6332
253J CTRP2 5.2321 10.2434 2.5996 9.9004
VM-CUB-1 CTRP2 6.1235 7.9421 4.3653 1.3246
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HeLa CTRP2 5.1265 6.2385 4.5143 2.0745

References

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3 The cytotoxic agents NSC-95397, brefeldin A, bortezomib and sanguinarine induce apoptosis in neuroendocrine tumors in vitro. Anticancer Res. 2010 Jan;30(1):149-56.