Details of the Drug

General Information of Drug (ID: DMX82DO)

Drug Name
Buformin
Synonyms
Buformin; 1-Butylbiguanide; Buformine; Butyldiguanide; Butylbiguanide; Butformin; Butylbiguanidum; Glybigid; 1-Butyldiguanide; Glybigidum; N-Butylbiguanide; Buformina; Buforminum; Buformine [INN-French]; Buforminum [INN-Latin]; Buformina [INN-Spanish]; Silubin; Adebit; BIGUANIDE, 1-BUTYL-; Buformin [USAN:INN]; W 37; Buformin HCl; Imidodicarbonimidic diamide, N-butyl-; Sindiatil; Panformin; Diabrin; Biforon; Andere; UNII-W2115E9C7B; Buformine HCl; N-butylimidodicarbonimidic diamide; DBV hydrochloride; H 224
Affected Organisms
Humans and other mammals
ATC Code
A10BA03: Buformin
A10BA: Biguanides
A10B: BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
A10: DRUGS USED IN DIABETES
A: ALIMENTARY TRACT AND METABOLISM
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski):
0		 Molecular Weight 157.22
Logarithm of the Partition Coefficient Not Available
Rotatable Bond Count 4
Hydrogen Bond Donor Count 3
Hydrogen Bond Acceptor Count 1
ADMET Property
Clearance
The drug present in the plasma can be removed from the body at the rate of 6.58 mL/min/kg [1]
Half-life
The concentration or amount of drug in body reduced by one-half in 4.62 hours [1]
Unbound Fraction
The unbound fraction of drug in plasma is 0.9% [1]
Vd
Fluid volume that would be required to contain the amount of drug present in the body at the same concentration as in the plasma 1.84 L/kg [1]
Chemical Identifiers
Formula
C6H15N5
IUPAC Name
2-butyl-1-(diaminomethylidene)guanidine
Canonical SMILES
CCCCN=C(N)N=C(N)N
InChI
InChI=1S/C6H15N5/c1-2-3-4-10-6(9)11-5(7)8/h2-4H2,1H3,(H6,7,8,9,10,11)
InChIKey
XSEUMFJMFFMCIU-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
2468
ChEBI ID
CHEMBL3209
CAS Number
692-13-7
UNII
W2115E9C7B
DrugBank ID
DB04830
VARIDT ID
DR01669
Drug ADMET Endpoint Profile (DAE)NEW Click to Jump to the Detailed DAE Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Organic cation transporter 1 (SLC22A1) DTT79CX S22A1_HUMAN Substrate [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds
2 Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007.