Details of the Drug

General Information of Drug (ID: DMXA6B3)

Drug Name
RO-4929097
Synonyms
RO4929097; 847925-91-1; Ro 4929097; UNII-KK8645V7LE; KK8645V7LE; RG-4733; N1-[(7S)-6,7-dihydro-6-oxo-5H-dibenz[b,d]azepin-7-yl]-2,2-dimethyl-N3-(2,2,3,3,3-pentafluoropropyl)propanediamide; n1-((7s)-6,7-dihydro-6-oxo-5h-dibenz(b,d)azepin-7-yl)-2,2-dimethyl-n3-(2,2,3,3,3-pentafluoropropyl)propanediamide; OJPLJFIFUQPSJR-INIZCTEOSA-N; cc-19; MLS006011071; SCHEMBL1376366; GTPL7338; CHEBI:86474; DTXSID20233833; C22H20F5N3O3; MolPort-016-633-243; BCPP000088; EX-A1750; ZINC43208642; ABP000966; s1575; AKOS027250816
Indication
Disease Entry ICD 11 Status REF
Breast cancer 2C60-2C65 Phase 2 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 469.4
Logarithm of the Partition Coefficient (xlogp) 4.6
Rotatable Bond Count (rotbonds) 5
Hydrogen Bond Donor Count (hbonddonor) 3
Hydrogen Bond Acceptor Count (hbondacc) 8
Chemical Identifiers
Formula
C22H20F5N3O3
IUPAC Name
2,2-dimethyl-N-[(7S)-6-oxo-5,7-dihydrobenzo[d][1]benzazepin-7-yl]-N'-(2,2,3,3,3-pentafluoropropyl)propanediamide
Canonical SMILES
CC(C)(C(=O)NCC(C(F)(F)F)(F)F)C(=O)N[C@H]1C2=CC=CC=C2C3=CC=CC=C3NC1=O
InChI
InChI=1S/C22H20F5N3O3/c1-20(2,18(32)28-11-21(23,24)22(25,26)27)19(33)30-16-14-9-4-3-7-12(14)13-8-5-6-10-15(13)29-17(16)31/h3-10,16H,11H2,1-2H3,(H,28,32)(H,29,31)(H,30,33)/t16-/m0/s1
InChIKey
OJPLJFIFUQPSJR-INIZCTEOSA-N
Cross-matching ID
PubChem CID
49867930
ChEBI ID
CHEBI:86474
CAS Number
847925-91-1
UNII
KK8645V7LE
DrugBank ID
DB11870
TTD ID
D0I3WC

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Gamma-secretase (GS) TT9W8GU APH1A_HUMAN ; APH1B_HUMAN ; PEN2_HUMAN ; NICA_HUMAN ; PSN1_HUMAN Modulator [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Breast cancer
ICD Disease Classification 2C60-2C65
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Gamma-secretase (GS) DTT APH1A; APH1B; NCSTN; PSENEN; PSEN1 1.47E-02 -0.09 -0.37
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 60 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MEC1 CTRP2 6.2884 11.543 3.4957 10.2242
JM1 CTRP2 6.3155 7.6588 5.4505 2.0195
Pfeiffer CTRP2 3.2978 9.434 1.7381 23.9807
EoL-1 CTRP2 4.1282 7.0882 3.5981 14.7039
HH [Human lymphoma] CTRP2 4.1577 11.3668 1.6839 21.9308
Daudi CTRP2 4.3238 10.0835 2.4582 18.6509
EB1 CTRP2 5.293 10.3676 3.2286 13.3386
CA46 CTRP2 5.3822 13.0597 1.9707 18.0657
DND-41 CTRP2 5.6253 17.1021 0.1625 23.4772
GA-10 CTRP2 5.9396 12.7255 2.6161 14.4496
OCI-Ly3 CTRP2 5.9474 15.2852 1.3429 19.1151
697 CTRP2 6.0005 7.7281 5.1657 3.7789
NU-DHL-1 CTRP2 6.0428 9.0426 4.544 6.3096
BL-70 CTRP2 6.0734 7.4166 5.3823 2.7275
SUP-M2 CTRP2 6.1021 9.5599 4.3345 7.0761
LP-1 CTRP2 6.2016 7.8704 5.2589 3.0105
KMS-20 CTRP2 6.2301 10.0095 4.2144 7.3396
DB CTRP2 6.2462 7.8346 5.3114 2.7128
SEM CTRP2 6.2505 10.7665 3.8528 8.8135
OPM-2 CTRP2 6.3199 7.672 5.4472 2.026
TF-1 CTRP2 6.3444 8.3604 5.1259 3.3192
ST486 CTRP2 6.3781 8.0966 5.2814 2.6176
A4/Fukuda CTRP2 6.3964 10.9127 3.897 8.3615
Mino CTRP2 6.3995 10.6079 4.0514 7.7125
Hs 611.T CTRP2 6.5062 9.7026 4.5845 5.3007
HD-MY-Z CTRP2 6.6163 8.0904 5.4497 1.5875
JJN-3 CTRP2 6.726 10.2811 4.4637 5.4381
MOTN-1 CTRP2 6.7731 9.4056 4.9256 3.4686
HEL 92.1.7 CTRP2 6.7892 8.6746 5.2861 2.0037
HuT 78 CTRP2 6.7901 10.0345 4.6315 4.6447
SUP-HD1 CTRP2 6.8077 9.5314 4.8887 3.5672
OCI-AML-5 CTRP2 6.8266 8.0609 5.5892 0.8306
RPMI-6666 CTRP2 6.8548 8.6044 5.3602 1.6366
Karpas-422 CTRP2 6.8602 9.9853 4.7055 4.2348
K-562 CTRP2 6.867 8.819 5.2681 1.9751
CMK CTRP2 6.8746 9.0707 5.1546 2.4086
JeKo-1 CTRP2 6.8951 10.0259 4.7103 4.1627
Kasumi-1 CTRP2 6.9403 11.3109 4.1153 6.5301
HL-60 CTRP2 6.9441 12.9826 3.2936 9.8821
A3/Kawakami CTRP2 7.0135 10.6272 4.5018 4.8349
MOLT-3 CTRP2 7.0294 16.5584 1.5841 16.2176
SET-2 CTRP2 7.0695 9.9901 4.8465 3.3662
Namalwa CTRP2 7.0933 8.9569 5.3415 1.4404
Ci-1 CTRP2 7.1427 7.9678 5.7741 0.1308
F-36P CTRP2 7.1448 9.9366 4.9212 2.9719
L-428 CTRP2 7.1851 9.0176 5.3663 1.2607
OCI-M1 CTRP2 7.1931 8.8424 5.4469 0.98
HuNS1 CTRP2 7.2482 17.3412 1.3652 16.5801
U266B1 CTRP2 7.2842 9.8803 5.0348 2.3632
Kasumi-2 CTRP2 7.3712 14.2462 2.9898 10.3823
EJM CTRP2 7.4161 14.5248 2.886 10.7158
Granta-519 CTRP2 7.4258 15.1695 2.5757 11.8979
RL CTRP2 7.4289 9.3124 5.369 1.0358
Toledo CTRP2 7.6078 10.395 4.9925 2.1623
MOLP-8 CTRP2 7.6682 9.2592 5.505 0.4868
AML-193 CTRP2 7.9701 9.4393 5.5624 0.2433
SUP-B15 CTRP2 8.4006 15.6055 3.0563 8.5651
OCI-Ly10 CTRP2 8.438 19.3843 1.2489 14.9868
OCI-Ly19 CTRP2 8.9047 29.8781 -3.5807 26.1653
KO52 CTRP2 10.3929 22.5803 1.0591 12.7877
⏷ Show the Full List of 60 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 13 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE15 CTRP2 9.0439 18.3073 2.1967 10.8286
EC-GI-10 CTRP2 5.9307 6.8956 5.5206 2.4313
KYSE-520 CTRP2 6.495 8.3791 5.2279 2.6539
TE-14 CTRP2 6.5498 9.4913 4.7219 4.6566
OE19 CTRP2 6.8353 8.2177 5.5247 1.0492
TE-5 CTRP2 6.8676 9.0074 5.1799 2.3182
OE21 CTRP2 7.301 10.602 4.7085 3.6024
OE33 CTRP2 7.3608 9.298 5.3394 1.1904
TE-11 CTRP2 7.3778 9.962 5.0536 2.1864
KYSE-150 CTRP2 7.7451 8.8899 5.6734 0.1302
KYSE-450 CTRP2 7.7611 9.4726 5.4626 0.5434
KYSE-510 CTRP2 8.1591 9.7148 5.536 0.2321
KYSE-30 CTRP2 8.4594 9.6741 5.6577 0.0464
⏷ Show the Full List of 13 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 19 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
N2a-PK1 CTRP2 7.9775 9.8789 5.3994 0.5866
Panc 10.05 CTRP2 6.9165 9.8447 4.8128 3.7159
MIA PaCa-2 CTRP2 7.0385 13.772 2.9746 10.9977
PSN1 CTRP2 7.0522 8.9357 5.3272 1.536
Panc 04.03 CTRP2 7.3174 10.7755 4.6371 3.862
Panc 02.03 CTRP2 7.375 9.3812 5.311 1.2733
Panc 08.13 CTRP2 7.3817 15.573 2.3435 12.8503
KP-2 CTRP2 7.4079 8.6434 5.6303 0.3176
AsPC-1 CTRP2 7.4563 13.1432 3.5918 7.852
Panc 03.27 CTRP2 7.5598 9.3475 5.4196 0.7824
PaTu 8988t CTRP2 7.6175 8.8589 5.6356 0.2255
PaTu 8988s CTRP2 8.0579 13.4394 3.8602 5.9286
HuP-T3 CTRP2 8.0656 10.6857 5.1131 1.3392
PK-45H CTRP2 8.1237 15.8575 2.7441 10.1543
DAN-G CTRP2 8.1349 9.3236 5.6637 0.0748
Capan-2 CTRP2 8.218 10.0538 5.4348 0.3983
Hs 766T CTRP2 8.3523 9.9174 5.5369 0.1823
Capan-1 CTRP2 9.7062 22.4811 0.6414 15.0104
SW1990 CTRP2 10.2464 23.5832 0.4816 14.7363
⏷ Show the Full List of 19 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 28 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SH4 CTRP2 8.9895 11.1358 5.3436 0.3116
Hs 940.T CTRP2 6.9381 10.3641 4.5764 4.6437
SK-MEL-3 CTRP2 7.0517 9.3551 5.1342 2.2626
A101D CTRP2 7.2039 10.2958 4.7899 3.4098
SK-MEL-2 CTRP2 7.2667 8.3356 5.6879 0.2526
Hs 934.T CTRP2 7.3734 8.4921 5.6731 0.2405
A2058 CTRP2 7.5364 8.5983 5.6985 0.1437
COLO 792 CTRP2 7.5964 13.3517 3.5894 7.6494
MeWo CTRP2 7.615 9.4069 5.4217 0.7392
Hs 688(A).T CTRP2 7.6736 8.75 5.6961 0.1153
WT2-iPS CTRP2 7.691 12.106 4.2515 4.8842
IGR-1 CTRP2 7.6975 16.8925 1.9288 13.8434
K029AX CTRP2 7.7301 9.2706 5.5275 0.4039
CJM [Human melanoma] CTRP2 7.7711 8.9862 5.649 0.1588
IGR-37 CTRP2 7.8538 9.0335 5.6631 0.1209
HMCB CTRP2 7.9107 9.1488 5.6436 0.1343
Hs 839.T CTRP2 7.937 9.334 5.5877 0.2105
IGR-39 CTRP2 7.9915 8.9948 5.7247 0.0425
LOX-IMVI CTRP2 8.2357 10.123 5.4161 0.4298
Hs 895.T CTRP2 8.4697 15.058 3.3632 7.299
SK-MEL-24 CTRP2 8.5095 22.8316 -0.3938 19.7835
COLO 829 CTRP2 8.5714 10.3605 5.4619 0.2382
Malme-3M CTRP2 8.6039 11.957 4.8503 1.742
Hs 294T CTRP2 9.5263 15.6706 3.73 4.6887
WM266-4 CTRP2 9.5976 16.79 3.2647 6.2708
WM115 CTRP2 10.3094 28.6904 -1.9509 20.9112
UACC-62 CTRP2 10.9751 24.1063 0.718 13.0777
HT-144 CTRP2 11.8509 21.1442 2.6081 6.1594
⏷ Show the Full List of 28 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 CTRP2 8.3215 10.2842 5.391 0.4478
Cancer Drug Sensitivity Data Curated from 9 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CHP-212 CTRP2 6.3555 14.1674 2.2391 15.0882
NH-6 CTRP2 6.913 9.8311 4.8169 3.7043
SK-N-FI CTRP2 7.2158 20.7403 -0.3516 21.8503
SK-N-AS CTRP2 7.5265 9.1261 5.4937 0.5953
IMR-32 CTRP2 7.6098 8.7321 5.6786 0.1552
SK-N-SH CTRP2 7.7528 10.7398 4.9212 2.2682
SK-N-DZ CTRP2 7.7818 9.2886 5.5423 0.3491
SK-N-BE(2) CTRP2 8.5194 10.1207 5.5271 0.16
KP-N-YN CTRP2 8.6588 10.7202 5.3656 0.3738
⏷ Show the Full List of 9 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-869 CTRP2 9.3116 16.8391 3.0661 7.3295
Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-N-MC CTRP2 6.2811 7.5777 5.465 2.0148
TC71 CTRP2 6.6265 7.8469 5.5697 1.1121
Hs 822.T CTRP2 7.3172 8.2412 5.7428 0.1326
SK-ES-1 CTRP2 7.336 8.8897 5.4995 0.7032
SaOS-2 CTRP2 7.3915 9.3087 5.3511 1.125
A-673 CTRP2 7.5221 9.5036 5.3357 1.0665
MG-63 CTRP2 8.0375 9.7283 5.4827 0.3708
HOS CTRP2 8.1475 9.3016 5.6755 0.0633
Hs 888.T CTRP2 8.1756 10.0414 5.4219 0.4422
G-292 clone A141B1 CTRP2 9.15 10.6965 5.5523 0.0565
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 55 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DU4475 CTRP2 6.5357 9.5632 4.6757 4.8714
MDA-MB-453 CTRP2 6.5855 8.6079 5.1808 2.7094
BT-20 CTRP2 6.6413 8.804 5.1248 2.8539
AU565 CTRP2 6.702 8.7381 5.1984 2.4693
HCC2218 CTRP2 6.7415 12.7291 3.2637 10.3533
Hs 578Bst CTRP2 6.8775 8.8561 5.2574 2.0034
HCC1419 CTRP2 6.9148 9.2919 5.0761 2.6646
HCC1428 CTRP2 7.0123 8.6645 5.426 1.2211
HCC38 CTRP2 7.2233 10.0689 4.9093 2.9179
Hs 578T CTRP2 7.385 10.0103 5.0359 2.244
MDA-MB-415 CTRP2 7.3926 9.7606 5.1532 1.8073
T-47D CTRP2 7.3945 12.2824 3.9664 6.4379
HCC202 CTRP2 7.5574 9.7316 5.2567 1.2932
ZR-75-30 CTRP2 7.6906 9.3936 5.4622 0.5831
BT-549 CTRP2 7.8533 10.7864 4.9572 2.0407
HCC1500 CTRP2 8.0338 9.2924 5.6385 0.1166
MDA-MB-157 CTRP2 8.2889 9.8063 5.5525 0.175
CAL-85-1 CTRP2 8.5657 10.4061 5.4434 0.2685
UACC-812 CTRP2 8.6275 25.5278 -1.6372 22.6779
MDA-MB-468 CTRP2 8.726 15.332 3.4 6.8243
MDA-MB-361 CTRP2 8.9529 10.7696 5.4591 0.1611
EFM-192A CTRP2 10.0477 27.9327 -1.7693 20.8696
BT 239 CTRP2 4.1982 27.2322 -6.1248 37.324
BT 330 CTRP2 6.3091 8.8338 4.8637 4.4748
BT 428 CTRP2 6.4332 8.1539 5.2935 2.4801
BT 422 CTRP2 6.6258 9.5198 4.7642 4.3573
BT 320 CTRP2 6.9612 8.8712 5.3023 1.7306
BT 248 CTRP2 6.9946 11.8058 3.9121 7.2772
BT 444 CTRP2 7.0231 8.6382 5.4437 1.1478
BT 416 CTRP2 7.0244 8.8746 5.3385 1.5247
BT 112 CTRP2 7.1349 15.0101 2.4347 12.9281
BT 498 CTRP2 7.1665 8.5857 5.5422 0.6976
BT 224 CTRP2 7.2223 9.8647 5.0039 2.5543
BT147 CTRP2 7.3572 13.62 3.2872 9.2266
BT 232 CTRP2 7.4956 9.4097 5.3618 1.005
BT 504 CTRP2 7.5604 12.6154 3.9204 6.3798
BT 482 CTRP2 7.5624 9.0111 5.5552 0.4187
BT 179 CTRP2 7.6685 8.945 5.6242 0.2295
BT 328 CTRP2 7.7928 11.6005 4.553 3.5885
BT 245 CTRP2 7.8344 10.6919 4.9883 1.9507
BT 216 CTRP2 7.8463 9.823 5.362 0.7588
BT 159 CTRP2 7.8484 18.5143 1.2417 15.9649
BT 145 CTRP2 7.9576 14.6401 3.2177 8.5799
BT 340 CTRP2 7.9602 9.5572 5.515 0.3351
BT 333 CTRP2 7.9788 9.4353 5.5673 0.2324
BT 139 CTRP2 8.2721 15.8684 2.8422 9.5628
BT 172 CTRP2 8.4412 16.5099 2.6494 10.0412
BT 440 CTRP2 8.5708 15.2687 3.3295 7.2928
BT 271 CTRP2 8.8367 18.6854 1.8725 12.266
BT 286 CTRP2 9.0623 25.2526 -1.1753 20.9196
BT 359 CTRP2 9.716 19.3095 2.1653 10.0306
BT 231 CTRP2 10.2293 21.28 1.5682 11.3753
BT 131 CTRP2 10.739 23.7731 0.721 13.3705
BT164 CTRP2 10.84 24.8911 0.2557 14.601
BT 228 CTRP2 12.3033 35.7732 -3.9821 22.3809
⏷ Show the Full List of 55 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SF539 CTRP2 6.8536 9.8057 4.788 3.9088
CCF-STTG1 CTRP2 6.8631 9.7609 4.8163 3.7798
D283 Med CTRP2 6.9139 12.6754 3.4227 9.4106
GMS-10 CTRP2 7.1303 9.9515 4.9048 3.0548
M059K CTRP2 7.1612 9.214 5.2652 1.6454
SF268 CTRP2 7.1822 8.97 5.3857 1.1966
T98G CTRP2 7.3317 11.5328 4.2848 5.2471
Hs 683 CTRP2 7.4067 8.9094 5.5252 0.5827
DK-MG CTRP2 7.4387 9.0704 5.4749 0.7042
TM-31 CTRP2 7.4811 9.7318 5.2156 1.5007
KNS-42 CTRP2 7.5096 8.8536 5.5932 0.3554
YH-13 CTRP2 7.7217 10.9124 4.8254 2.6496
U-118MG CTRP2 7.7616 9.5931 5.4151 0.6661
8-MG-BA CTRP2 7.8697 11.4563 4.6658 3.0754
KG-1-C CTRP2 8.1845 9.2793 5.6957 0.0449
42-MG-BA CTRP2 8.1863 14.9224 3.2387 8.1681
U-251MG CTRP2 8.252 13.5768 3.9206 5.4436
Becker CTRP2 8.2943 9.656 5.6067 0.108
SW1783 CTRP2 8.3494 10.8378 5.1877 0.9264
GOS-3 CTRP2 8.5731 13.803 4.0151 4.6976
YKG-1 CTRP2 8.5991 10.087 5.5673 0.1025
SNB-75 CTRP2 8.6191 14.9383 3.5164 6.5207
A-172 CTRP2 12.5396 25.106 1.2284 9.7361
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 9 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHUEM-1 CTRP2 6.5795 8.7829 5.0914 3.0834
JHUEM-3 CTRP2 6.8211 9.898 4.7203 4.2333
ESS-1 CTRP2 7.1487 10.346 4.7297 3.7228
HEC-1-A CTRP2 7.281 8.7812 5.5175 0.6888
JHUEM-7 CTRP2 7.291 12.5695 3.7534 7.4556
AN3-CA CTRP2 7.4675 10.6968 4.7702 3.1516
EN CTRP2 7.6369 9.4872 5.3994 0.7886
MFE-319 CTRP2 7.9546 9.7197 5.4511 0.4748
MFE-296 CTRP2 8.3262 9.8728 5.5429 0.1798
⏷ Show the Full List of 9 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 12 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
UO-31 CTRP2 6.5335 9.2987 4.8046 4.3399
786-O CTRP2 7.2539 9.1397 5.3506 1.2499
RCC10RGB CTRP2 7.3309 10.1124 4.9563 2.6054
KMRC-2 CTRP2 7.4553 11.602 4.3353 4.8717
KMRC-1 CTRP2 7.55 10.3209 4.9923 2.2241
VMRC-RCZ CTRP2 7.7906 9.4341 5.4905 0.4607
KMRC-3 CTRP2 7.9535 10.555 5.1112 1.4342
ACHN CTRP2 8.4001 10.0966 5.4911 0.2378
Caki-1 CTRP2 8.8154 10.371 5.5466 0.0932
TUHR14TKB CTRP2 8.8405 10.9252 5.3622 0.3234
CAL-54 CTRP2 9.3773 17.904 2.6089 8.9042
Caki-2 CTRP2 9.4494 14.3959 4.2486 2.9828
⏷ Show the Full List of 12 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 320 CTRP2 6.9129 9.5363 4.9584 3.1354
T84 CTRP2 6.9675 13.4099 3.0998 10.6207
HCT 15 CTRP2 7.0087 9.0633 5.2428 1.8998
NCI-H747 CTRP2 7.0187 13.929 2.8817 11.3985
RCM-1 [Human ESC] CTRP2 7.1083 10.1456 4.7983 3.5049
NCI-H716 CTRP2 7.1196 10.2788 4.7423 3.7123
HCC-56 CTRP2 7.3018 8.2683 5.7271 0.1634
SNU-C4 CTRP2 7.4227 8.7366 5.6008 0.3788
SNU-503 CTRP2 7.6222 16.4966 2.0679 13.4661
SW948 CTRP2 7.6998 8.9225 5.6446 0.1847
HCT 8 CTRP2 7.7901 8.9736 5.6606 0.1377
LS1034 CTRP2 7.9189 14.873 3.0779 9.1811
GP2d CTRP2 7.9384 20.0004 0.5751 17.9382
C2BBe1 CTRP2 8.0374 11.914 4.5572 3.2905
COLO 678 CTRP2 8.4454 16.7759 2.5239 10.501
SNU-1033 CTRP2 8.5321 10.8383 5.2689 0.6248
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 13 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHH-5 CTRP2 6.7286 9.0705 5.0566 3.0025
SNU-449 CTRP2 6.8197 8.6883 5.2992 1.914
HuH-1 CTRP2 6.9721 8.6045 5.4298 1.2484
SNU-475 CTRP2 7.0412 10.3114 4.6736 4.0981
JHH-6 CTRP2 7.2839 8.1847 5.7504 0.1297
SNU-423 CTRP2 7.2902 10.0007 4.9829 2.5528
JHH-1 CTRP2 7.3689 10.1954 4.9414 2.6171
JHH-4 CTRP2 7.4686 11.0328 4.6137 3.7558
PLC/PRF/5 CTRP2 7.5469 9.6484 5.2868 1.2034
HLF CTRP2 7.793 11.3269 4.679 3.1129
SK-HEP-1 CTRP2 8.1198 9.6062 5.5599 0.2049
SNU-387 CTRP2 8.5308 10.0432 5.5581 0.1221
JHH-2 CTRP2 12.08 25.6315 0.7073 11.7772
⏷ Show the Full List of 13 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 59 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DV-90 CTRP2 4.7043 11.8703 1.951 19.654
NCI-H1341 CTRP2 5.856 9.2784 4.2678 7.8387
NCI-H2171 CTRP2 5.9481 8.2554 4.8577 5.1773
NCI-H1563 CTRP2 6.0385 6.8225 5.6504 1.6674
NCI-H1703 CTRP2 6.2466 8.6407 4.9107 4.3892
NCI-H810 CTRP2 6.3081 9.0375 4.7615 4.9044
LK2 CTRP2 6.3736 7.665 5.4894 1.769
NCI-H1568 CTRP2 6.4431 8.6546 5.0549 3.4502
NCI-H2081 CTRP2 6.5096 9.1303 4.8699 4.1085
DMS 53 CTRP2 6.6578 9.3253 4.8828 3.8185
SK-MES-1 CTRP2 6.6896 10.5631 4.2976 6.1857
DMS 454 CTRP2 6.805 13.8972 2.7325 12.3589
NCI-H841 CTRP2 6.8163 8.6211 5.3285 1.805
NCI-H1915 CTRP2 6.8306 10.8126 4.2796 6.0295
NCI-H838 CTRP2 6.9069 8.5241 5.4282 1.3233
VMRC-LCD CTRP2 6.9111 11.9415 3.7833 7.9422
NCI-H520 CTRP2 6.9435 9.0035 5.2302 2.0264
NCI-H2029 CTRP2 7.0259 9.9466 4.8382 3.459
ChaGo-K-1 CTRP2 7.0509 9.5229 5.0554 2.5686
DMS 114 CTRP2 7.0823 9.2252 5.2132 1.9259
EKVX CTRP2 7.0967 12.849 3.4743 8.8962
DMS 273 CTRP2 7.1597 8.9942 5.3626 1.2984
NCI-H2196 CTRP2 7.1643 12.0441 3.919 6.98
NCI-H1105 CTRP2 7.1911 9.5676 5.122 2.143
RERF-LC-MS CTRP2 7.1944 9.3953 5.2026 1.8386
NCI-H522 CTRP2 7.2171 9.289 5.2638 1.5916
IA-LM CTRP2 7.2392 9.2576 5.2904 1.4741
NCI-H1793 CTRP2 7.2564 9.1841 5.3324 1.3101
COLO 668 CTRP2 7.3432 12.077 4.0299 6.2576
NCI-H1092 CTRP2 7.3505 9.4257 5.2781 1.4084
HCC1438 CTRP2 7.351 9.4472 5.269 1.4396
NCI-H23 CTRP2 7.3744 10.1751 4.9541 2.5626
NCI-H1395 CTRP2 7.479 11.8239 4.2451 5.198
HCC4006 CTRP2 7.5081 13.7721 3.322 8.8497
LC-1/sq-SF CTRP2 7.6471 9.0623 5.5718 0.3423
NCI-H1339 CTRP2 7.6594 11.7602 4.3943 4.3664
NCI-H2342 CTRP2 7.6986 11.1125 4.7203 3.0667
RERF-LC-Ad2 CTRP2 7.7682 9.7581 5.3516 0.8383
NCI-H1694 CTRP2 7.7917 9.1935 5.5819 0.2663
NCI-H1623 CTRP2 7.812 12.3212 4.2285 4.8153
NCI-H2170 CTRP2 7.8243 9.6063 5.4383 0.5706
KNS-62 CTRP2 7.874 9.3835 5.5447 0.3085
HOP-92 CTRP2 7.9147 10.4695 5.1275 1.4135
NCI-H647 CTRP2 7.9976 13.3547 3.8608 6.0067
NCI-H1944 CTRP2 8.0707 13.662 3.763 6.2901
HCC2935 CTRP2 8.0777 9.9782 5.4046 0.5245
Calu-1 CTRP2 8.1164 9.6456 5.5445 0.2303
NCI-H322 CTRP2 8.2122 9.6856 5.5665 0.1729
NCI-H2110 CTRP2 8.2521 10.6042 5.2364 0.8536
T3M-10 CTRP2 8.2576 17.027 2.2704 11.7142
HOP-62 CTRP2 8.5349 10.304 5.4682 0.2379
LUDLU-1 CTRP2 8.6141 15.9123 3.0527 8.2834
NCI-H1869 CTRP2 8.8549 10.7366 5.4348 0.2104
COR-L105 CTRP2 9.1477 18.0358 2.396 9.9741
NCI-H1651 CTRP2 9.2456 10.8316 5.5398 0.0567
COR-L95 CTRP2 9.6263 20.3334 1.6195 12.0087
NCI-H1693 CTRP2 9.6472 26.6816 -1.4473 20.6999
Lu-65 CTRP2 11.0889 28.9648 -1.5327 18.9077
Hs 888.Lu CTRP2 7.7412 10.9075 4.8391 2.5781
⏷ Show the Full List of 59 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Thigh Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
H-STS CTRP2 6.363 9.6949 4.4774 5.9966
P-STS CTRP2 7.24 10.9227 4.5153 4.4523
SYO-1 CTRP2 7.3142 10.9449 4.5544 4.1937
Cancer Drug Sensitivity Data Curated from 17 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
2004 CTRP2 6.6481 9.5607 4.7605 4.3373
OV-90 CTRP2 7.0659 8.9117 5.346 1.4529
COV362 CTRP2 7.2348 9.1511 5.335 1.3217
OAW42 CTRP2 7.3304 8.6568 5.5911 0.4515
TOV-112D CTRP2 7.4028 9.437 5.3017 1.2795
JHOM-1 CTRP2 7.4047 9.547 5.2547 1.438
TOV-21G CTRP2 7.4567 9.0097 5.5081 0.5987
EFO-27 CTRP2 7.4675 9.9355 5.1178 1.8571
OV7 CTRP2 7.5584 10.8526 4.7543 3.1023
COV434 CTRP2 7.6269 10.2115 5.0851 1.8138
OC 314 CTRP2 7.7677 9.003 5.6417 0.1708
OV56 CTRP2 7.8209 8.9374 5.6846 0.1011
OAW28 CTRP2 7.9838 13.0775 3.983 5.5481
JHOS-2 CTRP2 8.244 9.5405 5.6283 0.0934
EFO-21 CTRP2 8.2732 9.6559 5.5992 0.1197
COV644 CTRP2 8.7478 16.2807 2.966 8.4276
OVCAR-5 CTRP2 13.2007 33.1513 -2.1094 17.6226
⏷ Show the Full List of 17 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 20 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Aska-SS CTRP2 7.2762 8.7079 5.5453 0.6106
Yamato-SS CTRP2 12.1124 29.3536 -1.0237 16.3905
TE 617.T CTRP2 6.5328 10.499 4.2099 6.8162
G-401 CTRP2 6.8233 10.3215 4.5151 5.071
BT-12 CTRP2 7.0538 8.2918 5.6087 0.5789
A-204 CTRP2 7.2504 11.9841 4.0097 6.4787
KYM-1 CTRP2 7.2761 8.9007 5.4651 0.8528
SK-LMS-1 CTRP2 7.28 9.5257 5.1938 1.7786
BT-16 CTRP2 7.3296 9.7315 5.1298 1.9588
HT-1080 CTRP2 7.3565 12.3489 3.9074 6.7324
TE 441.T CTRP2 7.3655 11.8115 4.1738 5.645
SW982 CTRP2 7.4279 9.3259 5.3627 1.0568
Hs 729.T CTRP2 7.4897 10.5657 4.8446 2.8413
GCT CTRP2 7.6134 11.617 4.4321 4.2782
MES-SA CTRP2 7.6469 8.8955 5.6338 0.2191
Tm87-16 CTRP2 7.7604 9.2158 5.5609 0.319
SK-UT-1 CTRP2 7.7758 11.9929 4.3596 4.3523
G-402 CTRP2 7.7789 11.4939 4.5937 3.4504
TTC-709 CTRP2 7.8285 9.41 5.5159 0.3861
RD CTRP2 8.6102 14.2184 3.8463 5.2856
⏷ Show the Full List of 20 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Clivus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U-CH1 CTRP2 7.7827 15.4983 2.6762 10.9371
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IST-Mes1 CTRP2 7.0508 8.9343 5.327 1.5384
MPP 89 CTRP2 8.7488 19.6388 1.3479 14.1795
JL-1 CTRP2 11.492 20.4468 2.7165 6.1547
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PaCa-3 CTRP2 5.7358 6.2035 5.654 2.3545
VCaP CTRP2 6.9826 9.8673 4.847 3.4842
DU145 CTRP2 7.3191 9.5195 5.219 1.647
LNCaP clone FGC CTRP2 7.4362 9.8773 5.126 1.86
NCI-H660 CTRP2 7.4695 8.9688 5.5304 0.5308
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 CTRP2 8.0195 9.8028 5.447 0.4546
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-16 CTRP2 5.7581 7.1128 5.2562 3.9105
HGC-27 CTRP2 6.1299 7.0003 5.6357 1.5597
SH-10-TC CTRP2 6.8602 8.1142 5.5843 0.8162
Hs 746.T CTRP2 6.9388 11.1601 4.1883 6.2327
HuG1-N CTRP2 7.2063 14.4473 2.7676 11.5257
IM95 CTRP2 7.2236 12.4501 3.7632 7.5207
SNU-601 CTRP2 7.2281 9.276 5.2759 1.5368
SNU-1 CTRP2 7.2934 10.9459 4.5401 4.2791
KATO III CTRP2 7.4145 16.0343 2.1403 13.5498
SNU-216 CTRP2 7.9324 9.845 5.3927 0.6275
LMSU CTRP2 7.9356 10.8566 4.9716 1.9129
MKN7 CTRP2 8.0317 13.5744 3.7789 6.2806
MKN74 CTRP2 10.4632 19.9262 2.3491 8.4761
KE-39 CTRP2 10.9055 19.2575 2.9143 6.0834
SNU-685 CTRP2 7.2239 9.4503 5.1951 1.8341
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 4 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
FTC-133 CTRP2 6.997 9.2152 5.1651 2.2112
FTC-238 CTRP2 7.3578 10.0074 5.021 2.3302
TT2609-C02 CTRP2 8.7562 15.7927 3.2026 7.5288
SW579 CTRP2 9.6975 17.1493 3.1603 6.5304
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PE/CA-PJ49 CTRP2 7.0699 9.9403 4.8705 3.2705
FaDu CTRP2 7.1824 9.112 5.323 1.4153
BICR 16 CTRP2 7.2258 9.3883 5.2242 1.7257
PE/CA-PJ34 (clone C12) CTRP2 7.2961 9.5235 5.2041 1.7246
BICR 22 CTRP2 7.2987 8.6627 5.5743 0.5149
HSC-2 CTRP2 7.722 11.2227 4.6838 3.1766
BICR 6 CTRP2 7.867 14.9017 3.0274 9.4552
BICR 56 CTRP2 8.0546 9.647 5.5198 0.2924
CAL-27 CTRP2 8.0802 9.456 5.5984 0.1585
SCC-4 CTRP2 8.1195 9.6444 5.5461 0.2269
PE/CA-PJ41 (clone D2) CTRP2 8.2554 9.7973 5.5431 0.196
SCC-9 CTRP2 8.3967 10.4473 5.3607 0.481
BICR 31 CTRP2 8.4247 16.4207 2.681 9.9471
PE/CA-PJ15 CTRP2 8.6014 9.9592 5.6111 0.0652
BICR 18 CTRP2 8.6037 15.4462 3.2671 7.4863
CAL-33 CTRP2 8.6279 10.0787 5.5802 0.087
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 9 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U-BLC1 CTRP2 6.343 8.108 5.2496 2.8067
UM-UC-1 CTRP2 6.45 16.0013 1.3998 17.9307
HT-1197 CTRP2 7.0426 9.2125 5.1947 2.0422
SCaBER CTRP2 7.3491 8.9822 5.4676 0.7895
KMBC-2 CTRP2 7.985 11.5673 4.6835 2.8839
BC-3C CTRP2 7.9878 9.3733 5.593 0.1884
647V CTRP2 8.2137 9.4542 5.6471 0.0798
J82 CTRP2 8.2892 14.8436 3.3456 7.6114
T24 CTRP2 8.3091 9.8954 5.5284 0.2045
⏷ Show the Full List of 9 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HeLa CTRP2 7.6016 8.5387 5.7433 0.0728

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7338).
2 Phase I study of RO4929097, a gamma secretase inhibitor of Notch signaling, in patients with refractory metastatic or locally advanced solid tumors. J Clin Oncol. 2012 Jul 1;30(19):2348-53.