Details of the Drug

General Information of Drug (ID: DMXRPT6)

Drug Name
GSK1070916
Synonyms GSK-1070916
Indication
Disease Entry ICD 11 Status REF
Advanced solid tumour 2A00-2F9Z Phase 1 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 1 Molecular Weight (mw) 507.6
Logarithm of the Partition Coefficient (xlogp) 3.9
Rotatable Bond Count (rotbonds) 7
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 4
Chemical Identifiers
Formula
C30H33N7O
IUPAC Name
3-[4-[4-[2-[3-[(dimethylamino)methyl]phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-ethylpyrazol-3-yl]phenyl]-1,1-dimethylurea
Canonical SMILES
CCN1C=C(C(=N1)C2=CC=C(C=C2)NC(=O)N(C)C)C3=C4C=C(NC4=NC=C3)C5=CC=CC(=C5)CN(C)C
InChI
InChI=1S/C30H33N7O/c1-6-37-19-26(28(34-37)21-10-12-23(13-11-21)32-30(38)36(4)5)24-14-15-31-29-25(24)17-27(33-29)22-9-7-8-20(16-22)18-35(2)3/h7-17,19H,6,18H2,1-5H3,(H,31,33)(H,32,38)
InChIKey
QTBWCSQGBMPECM-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
46885626
ChEBI ID
CHEBI:91362
CAS Number
942918-07-2
TTD ID
D0IQ0Z
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Aurora kinase B (AURKB) TT5LS6T AURKB_HUMAN Modulator [2]
Aurora kinase C (AURKC) TTLYXIT AURKC_HUMAN Modulator [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Advanced solid tumour
ICD Disease Classification 2A00-2F9Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Aurora kinase B (AURKB) DTT AURKB 3.52E-36 -0.82 -1.62
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1 3.9417 15.3543 -3.6226 22.8824
EW-18 GDSC1 -9.3279 6.8584 -12.161 70.8267
ES7 GDSC1 -8.9289 5.0024 -11.0394 72.3492
MHH-ES-1 GDSC1 -8.7234 12.3762 -13.8197 65.1214
ES8 GDSC1 -7.3233 -4.4093 -7.3271 92.2417
SK-ES-1 GDSC1 -6.0285 9.2706 -9.6926 61.6186
ES5 GDSC1 -3.7492 8.7294 -7.1314 54.661
EW-1 GDSC1 -3.4964 4.7857 -5.1532 55.1609
TC-71 GDSC1 -3.4309 3.1829 -4.4602 55.6973
SK-PN-DW GDSC1 -1.5052 40.7592 -20.7779 48.5259
CADO-ES1 GDSC1 -0.5103 2.12 -0.9306 26.0985
EW-7 GDSC1 -0.4997 12.2836 -5.722 41.2215
ES1 GDSC1 -0.2811 20.0321 -9.379 43.7411
EW-13 GDSC1 0.2259 8.4721 -3.1827 33.135
G-292 clone A141B1 GDSC1 0.3213 3.853 -0.1038 32.4047
ES4 GDSC1 0.5582 9.8937 -3.5945 33.0821
NOS-1 [Human HNSCC] GDSC1 0.6132 5.5062 -1.3665 23.274
EW-11 GDSC1 0.8533 7.5442 -2.1663 26.5419
ES6 GDSC1 1.2728 6.153 -1.112 18.9943
NY GDSC1 1.5138 3.0115 1.4281 18.8652
HuO9 GDSC1 1.899 4.2074 0.3537 6.1392
CAL-78 GDSC1 1.9132 3.1439 1.8339 14.8396
H-EMC-SS GDSC1 1.9914 9.298 -2.0986 22.0435
CHSA8926 GDSC1 2.3643 6.8769 -0.6158 11.9418
HuO-3N1 GDSC1 2.4222 7.642 -0.9487 14.0157
EW-3 GDSC1 2.5463 11.9068 -2.9631 24.1631
SJSA-1 GDSC1 2.7578 9.9443 -1.8331 18.2644
CHSA0011 GDSC1 3.0579 9.0328 -1.1731 13.6165
U2OS GDSC1 3.1219 7.8186 -0.5486 9.4261
EW-24 GDSC1 3.1516 4.5699 0.889 0.485
CHSA0108 GDSC1 3.4081 5.6658 0.5764 1.6342
MG-63 GDSC1 3.6958 5.032 0.9282 0.1605
CAL-72 GDSC1 3.7003 5.2978 0.8379 0.3545
HOS GDSC1 3.7436 4.9886 0.9592 0.104
A-673 GDSC1 3.7992 16.2784 -4.1798 25.0927
SaOS-2 GDSC1 3.8775 5.4182 0.8606 0.2373
EW-16 GDSC1 3.9842 14.5224 -3.1861 21.1474
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 146 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC1 -5.1215 10.8859 -9.4923 58.2215
NALM-6 GDSC1 -10.8228 -1.9473 -11.2008 87.0632
Reh GDSC1 -10.7038 4.6521 -12.8328 75.5027
Karpas-45 GDSC1 -10.4527 7.2868 -13.526 72.0958
SU-DHL-5 GDSC1 -10.3274 6.2446 -12.9981 73.0517
ST486 GDSC1 -10.3108 5.9277 -12.8632 73.3938
PF-382 GDSC1 -9.8423 1.6569 -10.9485 78.9158
RS4;11 GDSC1 -9.6547 1.2211 -10.6237 79.4646
OCI-AML-5 GDSC1 -9.0236 7.962 -12.272 69.1736
SUP-B15 GDSC1 -8.7037 4.7511 -10.7063 72.2757
ML-2 GDSC1 -8.4765 11.566 -13.212 65.2418
ALL-SIL GDSC1 -8.4682 -6.611 -8.4682 98.8451
Loucy GDSC1 -8.3552 -6.4257 -8.3552 98.5385
P30/OHK GDSC1 -8.1939 -6.5355 -8.1939 98.8614
697 GDSC1 -8.1705 -6.1288 -8.1706 97.9465
BV-173 GDSC1 -8.137 -1.4009 -8.4024 83.3387
OCI-Ly19 GDSC1 -7.9764 -2.8022 -8.0642 87.3163
KOPN-8 GDSC1 -7.7654 2.8942 -9.0573 73.1817
NKM-1 GDSC1 -7.6451 7.3192 -10.5564 67.145
MOLT-4 GDSC1 -7.375 11.7935 -12.1828 63.0236
KE-37 GDSC1 -7.3478 -2.1747 -7.4617 84.3937
P12-Ichikawa GDSC1 -7.1072 -5.4459 -7.1072 95.9081
RPMI-8402 GDSC1 -6.9188 2.305 -7.9505 72.161
CCRF-CEM GDSC1 -6.8348 -3.7455 -6.843 89.0225
CESS GDSC1 -6.5106 8.1083 -9.692 63.7541
BE-13 GDSC1 -6.2701 8.6219 -9.6608 62.7229
Kasumi-1 GDSC1 -6.0762 2.6327 -7.1363 69.051
SU-DHL-10 GDSC1 -6.0126 2.4848 -7.0198 69.0903
SU-DHL-16 GDSC1 -5.8463 33.0584 -20.8355 54.4904
SR GDSC1 -5.7809 3.4 -7.0731 66.8239
ALL-PO GDSC1 -5.7498 2.4265 -6.7155 68.2616
MV4-11 GDSC1 -5.6874 -1.8238 -5.7503 78.3803
MOLM-13 GDSC1 -5.5929 -1.7503 -5.6575 77.7138
MOLT-13 GDSC1 -5.5142 -4.4121 -5.5142 85.2525
NB4 GDSC1 -5.1972 6.6285 -7.6994 61.1606
P32/ISH GDSC1 -5.0707 -0.8211 -5.2053 72.3196
BL-41 GDSC1 -5.02 20.6464 -14.0088 55.0194
SUP-M2 GDSC1 -4.9662 8.4065 -8.2234 59.111
SIG-M5 GDSC1 -4.5416 1.7965 -5.2056 63.9137
GDM-1 GDSC1 -4.4061 2.1056 -5.1519 62.7105
MOLP-8 GDSC1 -4.2188 6.2179 -6.5057 57.7717
QIMR-WIL GDSC1 -3.9601 22.2098 -13.7759 52.7344
MOLT-16 GDSC1 -3.677 1.0824 -4.0644 59.311
VAL GDSC1 -3.5912 5.4569 -5.5306 55.3193
ATN-1 GDSC1 -3.4652 5.7606 -5.528 54.5397
Mono-Mac-6 GDSC1 -2.9656 1.5786 -3.4229 53.0035
HL-60 GDSC1 -2.9509 8.8388 -6.3843 51.3676
Karpas-620 GDSC1 -2.7912 4.146 -4.1498 51.0323
SU-DHL-8 GDSC1 -2.5964 51.299 -26.9811 49.9518
NOMO-1 GDSC1 -2.5887 27.3329 -15.0504 49.8995
NU-DUL-1 GDSC1 -2.4898 8.1718 -5.6179 49.2486
LC4-1 GDSC1 -2.2961 6.1914 -4.5169 47.932
BC-1 GDSC1 -2.151 6.901 -4.6937 47.2267
JSC-1 GDSC1 -1.5712 20.4137 -10.7101 47.3574
DND-41 GDSC1 -1.2912 6.2867 -3.5558 41.2455
SUP-T1 GDSC1 -1.0342 8.2414 -4.2367 41.2075
OCI-AML-2 GDSC1 -0.8353 12.6906 -6.2271 42.949
OPM-2 GDSC1 -0.5047 5.7316 -2.5258 34.2341
MY-M12 GDSC1 -0.3114 80.6319 -39.6798 48.4192
CTV-1 GDSC1 -0.254 2.6579 -0.8714 24.2981
HAL-01 GDSC1 -0.0659 2.5964 -0.6493 21.79
HH [Human lymphoma] GDSC1 -0.0052 7.3759 -2.852 33.0208
EM-2 GDSC1 0.1853 37.6398 -17.7705 45.8791
Sc-1 GDSC1 0.2305 15.5567 -6.7027 40.1002
KMS-12-BM GDSC1 0.2541 6.7436 -2.3033 29.7069
EB2 GDSC1 0.3261 10.0493 -3.8761 34.7464
SU-DHL-6 GDSC1 0.347 14.1567 -5.9034 38.682
Daudi GDSC1 0.4179 4.6695 -1.1353 22.7127
PL-21 GDSC1 0.6164 8.4922 -2.8457 30.3658
WIL2 NS GDSC1 0.6439 12.3979 -4.7689 35.7043
EoL-1 GDSC1 0.6571 7.2606 -2.1971 27.4904
OCI-M1 GDSC1 0.752 6.2053 -1.5887 23.9723
A3/Kawakami GDSC1 0.8033 8.8092 -2.8405 29.6085
LAMA-84 GDSC1 0.8424 6.7476 -1.7788 24.6388
MEG-01 GDSC1 0.8572 6.757 -1.7706 24.5345
GR-ST GDSC1 0.9604 6.1741 -1.39 21.9555
KG-1 GDSC1 1.0025 6.7595 -1.6456 23.2632
WSU-NHL GDSC1 1.2217 9.6752 -2.916 28.3278
OCI-AML-3 GDSC1 1.2325 18.5965 -7.3673 38.2136
JURL-MK1 GDSC1 1.2463 9.2226 -2.6689 27.2546
TUR GDSC1 1.2773 42.2816 -19.1723 44.7861
KMOE-2 GDSC1 1.3671 8.2445 -2.0789 24.1364
JJN-3 GDSC1 1.4956 7.8331 -1.7669 22.0462
H9 GDSC1 1.6713 21.2642 -8.3365 38.3172
WSU-DLCL2 GDSC1 1.7855 2.8756 0.9175 2.1786
RPMI-6666 GDSC1 1.8006 22.1692 -8.6824 38.408
HDLM-2 GDSC1 1.8461 7.3549 -1.2453 17.7674
JVM-2 GDSC1 1.8486 6.6704 -0.9026 15.5422
THP-1 GDSC1 1.9428 11.2866 -3.1291 26.6788
SK-MM-2 GDSC1 1.9574 7.2894 -1.1255 16.6362
CA46 GDSC1 1.9678 10.5639 -2.7485 25.0907
Ku812 GDSC1 1.9692 8.1067 -1.5228 19.0164
K-562 GDSC1 1.9808 7.9826 -1.4519 18.5629
SCC-3 GDSC1 2.0065 3.9615 0.5475 4.3706
KMS-11 GDSC1 2.0386 4.546 0.288 6.2433
TK [Human B-cell lymphoma] GDSC1 2.0423 10.1183 -2.4671 23.6252
NK-92MI GDSC1 2.0685 6.8936 -0.8437 14.4198
Namalwa GDSC1 2.0919 16.4951 -5.6093 33.1445
SU-DHL-1 GDSC1 2.1206 9.3735 -2.0347 21.2961
P31/FUJ GDSC1 2.1301 7.1265 -0.9121 14.6809
BALL-1 GDSC1 2.1412 7.7733 -1.224 16.6529
DEL GDSC1 2.1941 10.9332 -2.7533 24.3834
HEL GDSC1 2.1954 9.1866 -1.8835 20.2693
A4/Fukuda GDSC1 2.2339 13.0042 -3.7535 27.9527
U-698-M GDSC1 2.261 4.5877 0.4179 4.6899
KM-H2 GDSC1 2.3366 8.6068 -1.4881 17.6206
L-540 GDSC1 2.3371 8.9434 -1.6542 18.5684
HC-1 GDSC1 2.3891 24.2364 -9.235 37.7638
CTB-1 GDSC1 2.4288 5.0807 0.2939 5.1884
MN-60 GDSC1 2.4536 7.2626 -0.7399 12.5304
KY821 GDSC1 2.5073 7.9755 -1.0501 14.4159
ROS-50 GDSC1 2.5112 8.0767 -1.0968 14.7017
KCL-22 GDSC1 2.5182 13.2161 -3.6354 26.7263
AMO1 GDSC1 2.5301 9.7139 -1.8893 19.2472
Hs 445 GDSC1 2.5376 19.4562 -6.7291 34.1034
MC116 GDSC1 2.5399 3.525 1.0296 0.3863
MLMA GDSC1 2.5471 10.4441 -2.2375 20.9566
Karpas-422 GDSC1 2.5895 13.4992 -3.7207 26.8065
Ramos.2G6.4C10 GDSC1 2.6061 21.6767 -7.7822 35.5559
BC-3 GDSC1 2.6383 10.801 -2.345 21.1942
RL GDSC1 2.6999 7.7941 -0.8233 12.3789
DG-75 GDSC1 2.7128 4.8802 0.555 2.7777
SUP-HD1 GDSC1 2.9572 13.0831 -3.2323 24.0274
HT GDSC1 3.0127 4.5316 0.8462 0.7528
YT GDSC1 3.0784 7.5336 -0.4423 8.8155
ARH-77 GDSC1 3.0916 12.7039 -2.9443 22.5166
L-428 GDSC1 3.1412 5.1209 0.6715 1.455
Raji GDSC1 3.1751 4.4701 0.9343 0.329
SU-DHL-4 GDSC1 3.1889 4.4233 0.9561 0.2639
Jiyoye GDSC1 3.1996 5.1241 0.6972 1.2591
DB GDSC1 3.2069 8.567 -0.848 11.1798
U266B1 GDSC1 3.2405 5.977 0.3628 3.0934
RPMI-8226 GDSC1 3.2889 13.9102 -3.392 23.7187
Karpas-299 GDSC1 3.3081 5.2103 0.7118 1.0793
MHH-PREB-1 GDSC1 3.3279 4.9028 0.8368 0.5548
ME1 GDSC1 3.4063 11.5295 -2.1398 18.0207
VL51 GDSC1 3.4102 13.0244 -2.8672 21.3297
JVM-3 GDSC1 3.5756 5.4311 0.7408 0.7359
RC-K8 GDSC1 3.5932 4.9739 0.9117 0.2203
L-363 GDSC1 3.6794 16.107 -4.184 25.4004
LP-1 GDSC1 3.7616 14.2373 -3.2064 21.7837
Farage GDSC1 3.8137 13.1282 -2.6288 19.25
L-1236 GDSC1 3.8424 6.0926 0.6021 1.0819
EJM GDSC1 4.0241 14.0404 -2.9236 19.9891
RPMI-8866 GDSC1 4.1529 5.5702 0.9048 0.1049
Granta-519 GDSC1 4.2037 13.5198 -2.5473 17.9202
⏷ Show the Full List of 146 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OACP4 C GDSC1 -2.7867 19.3438 -11.287 50.3499
OACM5.1 C GDSC1 -0.7025 6.3249 -2.9995 36.8163
TE-12 GDSC1 1.8448 7.7746 -1.4555 19.0452
ESO-51 GDSC1 2.0128 5.32 -0.1087 9.3217
KYSE-50 GDSC1 2.2101 22.771 -8.6482 37.493
FLO-1 GDSC1 2.619 10.0326 -1.9799 19.4501
SK-GT-4 GDSC1 3.1523 8.2223 -0.7201 10.4875
HCE-4 GDSC1 3.4475 5.3441 0.7204 0.9166
ESO-26 GDSC1 3.5136 15.2695 -3.8947 24.8881
KYSE-220 GDSC1 3.5454 12.5212 -2.5238 19.4727
KYAE-1 GDSC1 4.1681 14.9925 -3.2845 21.0802
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1 3.7827 16.972 -4.5333 26.1982
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IMR-5 GDSC1 -6.4051 -5.3821 -6.4051 94.2849
CHP-134 GDSC1 -5.3717 6.3309 -7.7588 62.0062
KP-N-YS GDSC1 -4.73 -2.429 -4.7363 74.164
MHH-NB-11 GDSC1 -2.1967 1.4558 -2.5489 45.3439
NH-12 GDSC1 -1.5668 3.0098 -2.3996 40.0778
SJNB-6 GDSC1 -0.747 4.4478 -2.165 34.1166
NB69 GDSC1 -0.1558 9.819 -4.1931 37.3824
SK-N-FI GDSC1 0.4147 5.0192 -1.3089 23.8086
SJNB-10 GDSC1 0.4338 6.8948 -2.215 28.5223
SK-N-MC-IXC GDSC1 1.0473 3.2116 0.1599 10.6109
SJNB-7 GDSC1 1.2622 15.7455 -5.9169 35.9967
SJNB-5 GDSC1 1.3986 8.3817 -2.1213 24.229
GI-ME-N GDSC1 1.611 9.5378 -2.5243 25.3356
SiMa GDSC1 1.6762 6.9263 -1.167 17.8654
TGW GDSC1 1.7402 9.3434 -2.3221 23.9734
SK-N-SH GDSC1 1.8294 5.4648 -0.3184 11.4658
SJNB-12 GDSC1 1.8619 9.3205 -2.2128 23.0394
SJNB-13 GDSC1 2.1253 5.1417 0.0598 7.7234
NB(TU)1 GDSC1 2.1743 5.3945 -0.0285 8.245
LA-N-6 GDSC1 2.1981 7.0892 -0.8425 14.0006
SJNB-17 GDSC1 2.285 5.3794 0.0561 7.3059
SK-N-BE(2)-M17 GDSC1 2.5031 6.624 -0.394 9.9832
SK-N-DZ GDSC1 2.5338 5.1293 0.3373 4.6316
CHP-212 GDSC1 2.6595 16.4095 -5.1138 30.5513
Kelly GDSC1 2.7554 7.3983 -0.5933 10.6778
GOTO GDSC1 2.8967 8.7449 -1.1464 13.8959
SK-N-AS GDSC1 3.5327 14.9533 -3.7248 24.2661
KP-N-YN GDSC1 3.9211 14.7153 -3.3252 21.8406
SJNB-14 GDSC1 4.1098 13.5697 -2.636 18.5444
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC1 4.0221 14.8454 -3.3165 21.558
Cancer Drug Sensitivity Data Curated from 51 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCC1187 GDSC1 -7.3567 10.9748 -11.8026 63.5194
MDA-MB-468 GDSC1 -5.5281 -4.3595 -5.5281 88.2268
HCC1599 GDSC1 -4.2215 34.1341 -19.8853 52.248
OCUB-M GDSC1 -2.856 11.3504 -7.4738 50.7949
CAL-51 GDSC1 -0.771 4.4654 -1.4932 43.209
MFM-223 GDSC1 0.0037 3.1421 -0.8166 22.5893
MDA-MB-157 GDSC1 0.4428 5.4786 -0.5779 33.7827
CAL-85-1 GDSC1 0.7757 9.4863 -2.0568 36.7704
HCC38 GDSC1 0.8055 8.86 -1.7305 35.8227
BT-549 GDSC1 0.8092 10.3185 -2.423 37.4652
HCC70 GDSC1 0.8553 9.8409 -2.1496 36.67
ZR-75-30 GDSC1 1.1121 6.2423 -0.2144 29.1747
MDA-MB-231 GDSC1 1.1505 3.37 0.9453 23.1296
CAMA-1 GDSC1 1.3045 6.0142 0.0831 26.9628
CAL-120 GDSC1 1.5786 7.6273 -0.3957 28.0251
BT-20 GDSC1 1.8857 35.0214 -13.7179 44.2275
MDA-MB-436 GDSC1 1.9448 3.0724 1.8831 14.4314
HCC1569 GDSC1 2.0803 11.1444 -2.9484 25.5413
HCC2157 GDSC1 2.4907 6.4945 -0.34 9.6326
HCC1806 GDSC1 2.5024 6.7017 0.9277 17.8297
UACC-812 GDSC1 2.6632 5.3634 0.3086 4.5476
DU4475 GDSC1 2.67 15.8102 -4.8072 29.7625
EFM-19 GDSC1 2.7404 11.8564 -2.7897 22.8758
CAL-148 GDSC1 2.7522 4.2629 0.8359 1.0601
BT-474 GDSC1 2.7862 5.1739 0.4662 3.2253
JIMT-1 GDSC1 2.7969 7.3528 0.8746 17.1389
MRK-nu-1 GDSC1 3.0224 4.596 0.8256 0.834
Evsa-T GDSC1 3.0356 4.6701 0.8026 0.925
MDA-MB-415 GDSC1 3.0905 7.5403 1.0387 15.2446
EFM-192A GDSC1 3.1571 4.904 0.7648 0.9815
MDA-MB-361 GDSC1 3.2185 5.0953 0.7172 1.1429
HCC2218 GDSC1 3.4608 5.2134 0.7753 0.6881
Hs 578T GDSC1 3.5534 5.7941 0.5918 1.3977
HCC202 GDSC1 3.6374 14.664 -3.5056 23.2242
MDA-MB-330 GDSC1 3.71 10.193 -1.2882 12.625
HCC1500 GDSC1 3.7435 5.6719 2.5031 5.4479
HCC1954 GDSC1 3.8336 9.2575 0.7933 14.4874
HDQ-P1 GDSC1 3.9921 13.7577 -1.3246 23.8558
T-47D GDSC1 4.1383 16.4501 -2.5509 27.4293
BT-483 GDSC1 4.1434 5.7525 0.8404 0.2013
HCC1395 GDSC1 4.1934 8.5535 1.4179 9.9226
YMB-1-E GDSC1 4.347 6.3554 0.7054 0.4253
MDA-MB-453 GDSC1 4.3736 10.1788 0.7512 13.3079
UACC-893 GDSC1 4.4557 7.4812 2.1222 5.1121
HCC1428 GDSC1 4.5963 8.3056 1.8231 6.593
HCC1419 GDSC1 5.1368 6.7053 2.8325 0.5661
MCF-7 GDSC1 5.3362 8.0987 2.3608 2.3647
AU565 GDSC1 5.4162 14.3052 -0.5109 17.0361
MDA-MB-175-VII GDSC1 5.7569 7.6133 2.7462 0.4791
COLO 824 GDSC1 5.787 21.6446 -5.3748 24.1966
HCC1937 GDSC1 9.414 23.9088 -2.417 16.6149
⏷ Show the Full List of 51 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 54 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
GaMG GDSC1 -3.4193 22.1239 -13.234 51.6507
MOG-G-UVW GDSC1 -2.6131 6.0541 -4.7779 49.8203
SK-MG-1 GDSC1 -1.0185 6.6473 -2.594 46.1618
U-251MG GDSC1 0.1992 79.1054 -38.4868 48.0239
MOG-G-CCM GDSC1 0.9461 24.8919 -10.7552 41.9265
DK-MG GDSC1 0.9681 3.3365 0.0265 11.9698
H4 GDSC1 1.1536 7.9653 -2.1187 25.1343
NMC-G1 GDSC1 1.2683 9.8549 -2.9667 28.3533
D-566MG GDSC1 1.3217 16.4671 -6.2281 36.3532
Hs 683 GDSC1 1.3629 14.128 -3.7695 38.0279
CAS-1 GDSC1 1.6163 4.6521 -0.0803 10.3776
AM-38 GDSC1 1.7573 8.3141 -1.7944 21.2628
D-247MG GDSC1 1.9757 5.6873 -0.3173 10.9888
D-392MG GDSC1 2.0224 7.6342 -1.2464 17.1807
D-423MG GDSC1 2.123 8.4018 -0.2559 25.3338
M059J GDSC1 2.1759 10.3717 -2.488 23.2875
A-172 GDSC1 2.5031 6.71 -0.4357 10.2781
PFSK-1 GDSC1 2.5745 6.3304 -0.2035 8.4283
U-87MG ATCC GDSC1 2.6093 4.9065 0.4846 3.443
LN-405 GDSC1 2.7767 4.8539 0.6011 2.3741
D-502MG GDSC1 2.8115 6.5723 -0.1617 7.5268
LN-18 GDSC1 2.8284 4.0812 0.9398 0.5195
KS-1 [Human Krukenberg tumour] GDSC1 2.8917 8.8436 -1.1979 14.2276
YH-13 GDSC1 2.9256 9.5363 -0.0997 21.8594
D283 Med GDSC1 3.0407 4.3274 0.934 0.401
Becker GDSC1 3.0822 6.5414 0.0217 5.632
LNZTA3WT4 GDSC1 3.1253 4.9969 0.714 1.2568
SNB-75 GDSC1 3.1346 6.3489 0.1399 4.7252
D-542MG GDSC1 3.186 4.8406 0.8017 0.7943
D-263MG GDSC1 3.2405 4.6364 0.8996 0.3988
ONS-76 GDSC1 3.2526 24.7309 -8.7908 35.5452
KINGS-1 GDSC1 3.2535 6.4728 0.1525 4.4122
42-MG-BA GDSC1 3.2589 7.4493 -0.2885 7.3507
Onda 10 GDSC1 3.3443 5.4817 0.6208 1.4806
GB-1 GDSC1 3.4117 11.7059 -2.2218 18.4084
D-336MG GDSC1 3.453 18.7 -5.6362 29.8092
Daoy GDSC1 3.537 18.4603 -5.4533 29.1906
U-118MG GDSC1 3.5498 4.8938 0.9238 0.2089
KNS-42 GDSC1 3.6001 6.4414 0.3506 2.6193
SF295 GDSC1 3.6747 13.2145 -2.7694 20.2196
SF126 GDSC1 3.765 9.9842 -1.1535 11.6965
SW1088 GDSC1 3.7662 7.3335 0.0565 4.1124
KNS-81-FD GDSC1 3.8122 5.5201 0.8011 0.4037
LN-229 GDSC1 3.8836 7.402 0.089 3.7265
SW1783 GDSC1 4.0195 6.1586 0.6503 0.7644
GI-1 GDSC1 4.786 19.2934 -4.9396 25.0676
Onda 11 GDSC1 5.448 16.857 -3.3068 18.2943
8-MG-BA GDSC1 5.6538 16.1848 -2.8557 16.0603
T98G GDSC1 5.8115 12.7769 -1.2079 7.9201
YKG-1 GDSC1 6.1652 29.5664 -8.9695 30.6184
SF268 GDSC1 6.2702 24.6298 -6.4833 25.9507
SF539 GDSC1 6.342 18.2733 -3.3961 16.8597
DBTRG-05MG GDSC1 6.5626 17.3275 -2.8205 14.1748
KALS-1 GDSC1 7.7989 21.9192 -4.1809 17.0401
⏷ Show the Full List of 54 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TGBC24TKB GDSC1 1.4072 9.4938 -2.6703 26.6787
TGBC1TKB GDSC1 2.8814 7.8669 -0.7325 11.2765
ETK-1 GDSC1 3.2604 13.3278 -3.1263 22.7833
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
EN GDSC1 1.4133 15.1543 -4.2312 38.585
MFE-280 GDSC1 1.8386 6.8412 -0.9954 16.193
AN3-CA GDSC1 1.8844 5.7709 -0.4279 12.0919
KLE GDSC1 2.687 8.1385 -1.0001 13.5684
MFE-296 GDSC1 2.6879 5.2767 0.3631 4.1163
RL95-2 GDSC1 3.6055 5.1726 0.8467 0.3727
MFE-319 GDSC1 3.606 5.6564 2.407 5.3021
ESS-1 GDSC1 4.4988 14.5531 -2.8425 18.5108
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
786-O GDSC1 -0.5638 5.0341 -1.474 41.9134
VMRC-RCZ GDSC1 0.8302 8.9804 -1.7636 35.8081
LB1047-RCC GDSC1 1.1485 5.6226 0.0966 27.5693
769-P GDSC1 1.2267 10.5887 -2.1585 35.2589
ACHN GDSC1 1.5754 6.1055 0.3147 24.6809
UO-31 GDSC1 1.6049 8.5143 -0.7963 29.5533
CAL-54 GDSC1 1.8149 4.3803 0.2073 7.5185
SN12C GDSC1 2.2099 5.5254 1.2133 17.2111
RCC10RGB GDSC1 2.2823 7.7083 0.2311 27.0183
KTCTL-140 GDSC1 2.2857 5.7531 -0.1241 8.6377
BFTC-909 GDSC1 2.3311 5.4418 0.0577 7.1706
LB996-RCC GDSC1 2.3833 3.9323 2.0959 11.3107
KTCTL-26A GDSC1 2.4155 5.0457 0.3018 5.1624
SW13 GDSC1 2.663 4.478 2.1486 9.8977
BB65-RCC GDSC1 2.6685 8.3814 0.2497 20.9732
KMRC-20 GDSC1 2.7007 7.7531 0.5901 19.0571
KMRC-1 GDSC1 2.7511 5.7886 0.1665 5.3518
A-704 GDSC1 2.7797 4.9531 0.5597 2.6299
KTCTL-1M GDSC1 2.7813 8.6896 -1.2014 14.5627
SW156 GDSC1 2.8603 5.5263 1.8345 11.136
Caki-1 GDSC1 2.9157 10.4867 -0.5826 24.0713
KTCTL-21 GDSC1 3.2278 10.4904 -1.7608 16.5415
A-498 GDSC1 3.3277 4.6246 0.9367 0.2569
KTCTL-195 GDSC1 3.3306 11.0767 -1.9731 17.3825
OS-RC-2 GDSC1 3.4463 11.1103 -0.4461 21.8479
NCC021 GDSC1 3.515 5.5053 0.6874 0.9989
KTCTL-13 GDSC1 3.6516 5.9512 0.5739 1.3828
RXF 393L GDSC1 3.7625 17.4624 -3.3613 30.4557
HA7-RCC GDSC1 3.854 12.9743 -1.0446 23.1726
LB2241-RCC GDSC1 3.9694 7.0849 1.9749 7.0831
VMRC-RCW GDSC1 4.0191 5.6285 0.8389 0.2382
TK-10 GDSC1 4.0774 14.0065 -1.3805 23.8315
⏷ Show the Full List of 32 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 44 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-175 GDSC1 -5.5423 10.6057 -9.7895 59.5088
SW48 GDSC1 -5.0912 29.4375 -18.363 53.8648
NCI-H716 GDSC1 -0.4178 2.2188 -0.8687 25.1722
COLO205 GDSC1 -0.1002 94.1873 -46.2786 48.5196
HCT 116 GDSC1 0.1379 19.0169 -8.5089 42.1143
KM12 GDSC1 0.661 9.5307 -3.3239 31.8562
SW948 GDSC1 0.8536 5.6993 -1.2472 21.522
LS411N GDSC1 0.9897 17.11 -6.8282 38.141
LS513 GDSC1 1.0231 6.2453 -1.3713 21.5903
LS1034 GDSC1 1.2817 6.5972 -1.3266 20.308
NCI-H747 GDSC1 1.3539 5.9311 -0.9332 17.5087
SNU-407 GDSC1 1.8106 9.7312 -2.4589 24.3592
CW-2 GDSC1 1.8225 5.9152 -0.5473 13.1599
CCK-81 GDSC1 2.0504 7.3993 -1.1081 16.2176
COLO 320HSR GDSC1 2.1024 6.7234 -0.7337 13.5614
CL-11 GDSC1 2.3402 4.3376 0.5838 3.3144
T84 GDSC1 2.4791 9.8793 -2.0096 20.0299
SW626 GDSC1 2.5651 5.4094 0.2266 5.3504
HT115 GDSC1 2.6045 4.4258 0.6944 2.0755
HCC2998 GDSC1 2.6626 8.6883 -1.2864 15.4269
SW1417 GDSC1 2.7851 3.7718 2.5852 6.8202
HCT 15 GDSC1 2.8077 6.9375 -0.3373 8.7695
SNU-1040 GDSC1 2.8484 30.2886 -11.8861 39.2666
RCM-1 [Human ESC] GDSC1 3.0258 5.8759 0.2893 3.943
RKO GDSC1 3.3417 19.0031 -5.8722 30.5874
SW1116 GDSC1 3.345 4.8617 0.8586 0.4707
COLO 678 GDSC1 3.3461 5.5249 0.6043 1.5627
SNU-C1 GDSC1 3.4191 10.0677 -1.4234 14.1443
SW620 GDSC1 3.5523 14.0815 -3.282 22.6123
C2BBe1 GDSC1 3.5671 5.4726 0.7218 0.8152
SNU-C5 GDSC1 3.5982 12.4206 -2.4372 18.9374
SW1463 GDSC1 3.7384 6.0449 0.5756 1.2903
SNU-61 GDSC1 3.7594 13.235 -2.7191 19.7847
SNU-81 GDSC1 3.87 12.6503 -2.3579 17.8698
HT-55 GDSC1 3.9366 5.2405 0.941 0.0953
SNU-C2B GDSC1 3.9453 8.7587 -0.4749 7.1083
LS180 GDSC1 4.027 19.4901 -5.5926 28.3985
LoVo GDSC1 4.0274 5.9349 0.7346 0.4889
GP5d GDSC1 4.6126 14.6963 -2.834 18.212
SW837 GDSC1 4.6972 14.9582 -2.9022 18.3057
CaR-1 GDSC1 4.9461 16.3577 -3.4048 19.7444
MDST8 GDSC1 5.266 13.7589 -1.9688 12.8181
LS123 GDSC1 5.3482 20.1761 -4.9702 23.9755
HT-29 GDSC1 5.787 16.0245 -2.6964 15.119
⏷ Show the Full List of 44 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1 3.3673 15.1055 -3.9229 25.3568
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HLE GDSC1 -0.9506 9.6619 -3.8428 46.7054
SNU-398 GDSC1 -0.6812 35.8527 -17.618 47.0666
JHH-7 GDSC1 -0.4505 5.0904 -1.3736 41.0265
JHH-1 GDSC1 0.1538 8.582 -2.2428 39.8271
SNU-387 GDSC1 1.6997 12.6148 -3.9895 30.3149
JHH-6 GDSC1 2.1228 3.4564 0.8551 1.8896
Huh-7 GDSC1 2.6709 4.5791 0.6635 2.1589
SK-HEP-1 GDSC1 2.6908 3.8582 0.9668 0.5178
Hep 3B2.1-7 GDSC1 2.8234 4.8716 0.6181 2.1939
JHH-4 GDSC1 2.8579 13.851 -2.3121 30.2533
Hep-G2/C3A GDSC1 3.2285 4.5873 0.9127 0.3656
SNU-449 GDSC1 3.2427 8.0412 -0.5753 9.3085
HuH-1 GDSC1 3.3299 4.6459 0.93 0.2723
SNU-423 GDSC1 3.5695 16.4514 -4.4357 26.4334
JHH-2 GDSC1 5.2243 11.6159 0.6605 11.8091
SNU-475 GDSC1 7.6166 18.2883 -2.6373 11.6364
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 172 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H524 GDSC1 -9.8135 0.2002 -10.5385 81.6572
NCI-H847 GDSC1 -8.8354 -0.8431 -9.2522 82.8276
NCI-H2171 GDSC1 -8.6647 1.0038 -9.4857 78.4371
IST-SL1 GDSC1 -8.1735 11.2412 -12.7587 64.9229
LK-2 GDSC1 -7.3513 18.2235 -15.1039 59.8821
NCI-H2227 GDSC1 -6.2015 -0.1183 -6.541 75.3241
NCI-H2081 GDSC1 -5.2804 20.7348 -14.2985 55.4927
LC-2/ad GDSC1 -4.579 14.8216 -10.7922 55.3669
LB647-SCLC GDSC1 -3.1063 12.6507 -8.3358 51.5711
COR-L321 GDSC1 -2.7819 24.2012 -13.6749 50.2786
Lu-134-A GDSC1 -2.6879 20.2761 -11.6544 50.1042
EPLC-272H GDSC1 -2.0869 19.8557 -10.8993 48.6244
NCI-H810 GDSC1 -1.3704 17.9852 -9.3272 46.4526
NCI-H647 GDSC1 -1.1615 7.3295 -3.0289 47.2548
A-427 GDSC1 -1.0287 6.0979 -2.3814 46.0243
COR-L311 GDSC1 -0.9588 45.2597 -22.5534 48.0044
NCI-H209 GDSC1 -0.8439 16.2554 -7.998 44.3652
LXF 289 GDSC1 -0.7906 5.3022 -1.8177 43.9049
HCC78 GDSC1 -0.5505 7.6375 -2.5302 43.6277
NCI-H446 GDSC1 -0.4985 3.051 -1.2922 28.3017
NCI-H1048 GDSC1 -0.4954 123.6403 -61.3357 49.0498
NCI-H1304 GDSC1 -0.2949 30.1424 -14.435 45.7999
LCLC-97TM1 GDSC1 -0.265 65.2708 -31.962 48.0102
NCI-H187 GDSC1 0.0803 7.7283 -2.947 32.9723
NCI-H1581 GDSC1 0.1329 7.4337 -2.7539 32.0549
NCI-H2795 GDSC1 0.2901 2.7333 0.1572 31.3232
DMS 273 GDSC1 0.3052 4.2164 -0.2426 33.103
NCI-H3255 GDSC1 0.4209 8.4842 -1.9322 37.976
NCI-H82 GDSC1 0.4634 42.1944 -19.8116 45.9339
NCI-H460 GDSC1 0.5254 5.518 -0.5074 33.1049
A-549 GDSC1 0.7031 6.4729 -0.7336 33.1308
SBC-3 GDSC1 0.7311 11.643 -4.317 34.3843
Lu-99A GDSC1 0.7313 7.0052 -0.9433 33.7523
NCI-H2731 GDSC1 1.0117 3.5198 -0.0246 12.1874
Lu-139 GDSC1 1.1134 16.0716 -6.2049 36.8907
NCI-H2122 GDSC1 1.2181 28.1867 -12.1743 42.2648
NCI-H358 GDSC1 1.2278 12.9127 -4.5294 33.2527
EBC-1 GDSC1 1.236 7.5223 -0.6794 30.5867
CAL-12T GDSC1 1.2919 14.3316 -5.1852 34.5257
NCI-H748 GDSC1 1.3095 21.1304 -8.5699 39.3814
NCI-H526 GDSC1 1.3373 13.6018 -4.7824 33.5086
HARA [Human squamous cell lung carcinoma] GDSC1 1.3412 14.921 -5.4388 34.8908
NCI-H1770 GDSC1 1.3613 17.9549 -6.939 37.3195
IST-SL2 GDSC1 1.3662 21.9174 -8.9161 39.594
NCI-H211 GDSC1 1.384 25.6145 -10.7498 41.0637
ChaGo-K-1 GDSC1 1.4098 9.2701 -1.3465 32.2557
NCI-H510A GDSC1 1.4576 8.1067 -1.935 23.0753
NCI-H2087 GDSC1 1.4637 12.1418 -3.9473 30.9444
NCI-H1693 GDSC1 1.5173 3.8492 0.2412 8.2204
NCI-H1688 GDSC1 1.5323 3.6527 1.2775 19.5947
EMC-BAC-1 GDSC1 1.5522 14.5427 -5.0745 33.5195
Ms-1 GDSC1 1.5656 6.7283 -1.1574 18.1988
NCI-H1944 GDSC1 1.5923 7.6414 -1.5919 20.7232
DMS 114 GDSC1 1.6626 3.7343 0.4118 6.4072
CPC-N GDSC1 1.6805 14.1156 -4.7553 32.4082
ABC-1 GDSC1 1.7642 22.7689 -9.0121 38.8265
NCI-H2228 GDSC1 1.8151 11.9604 -2.2892 33.4931
NCI-H1755 GDSC1 1.8185 8.6717 -1.9238 21.7376
NCI-H520 GDSC1 1.8286 9.3985 -2.2784 23.4653
NCI-H2818 GDSC1 1.8832 3.985 1.5418 16.5864
COR-L303 GDSC1 1.9285 15.3562 -5.1728 32.6596
PC-14 GDSC1 1.9354 11.5023 -3.2426 27.1224
NCI-H226 GDSC1 1.9361 3.9355 0.512 4.8268
SW1271 GDSC1 2.0236 7.5286 0.0768 24.1287
NCI-H1568 GDSC1 2.0388 6.148 0.7529 20.5076
NCI-H838 GDSC1 2.0879 9.2901 -0.7243 27.4632
COR-L23 GDSC1 2.1654 14.4632 -4.5358 30.443
NCI-H196 GDSC1 2.1719 4.9933 1.4205 16.1283
SK-MES-1 GDSC1 2.1916 7.8657 -1.2313 16.5364
SK-LU-1 GDSC1 2.2102 14.9626 -4.7491 30.8673
NCI-H1836 GDSC1 2.2342 6.7118 -0.6298 12.4307
LOU-NH91 GDSC1 2.2536 8.9754 -1.7338 19.275
NCI-H23 GDSC1 2.2624 4.704 1.6422 14.4621
NCI-H1869 GDSC1 2.2725 4.6695 0.3868 4.8898
UMC-11 GDSC1 2.2893 20.2714 -6.0062 38.5461
NCI-H2170 GDSC1 2.3177 28.6565 -11.5012 39.8874
NCI-H1092 GDSC1 2.339 7.1784 -0.782 13.1578
NCI-H1876 GDSC1 2.3558 18.5166 -6.4059 33.9832
NCI-H2135 GDSC1 2.3652 4.1629 0.6778 2.6148
NCI-H1155 GDSC1 2.4176 5.2566 0.2037 5.8723
BEN GDSC1 2.4334 9.0646 -1.6413 18.1946
NCI-H1436 GDSC1 2.4494 20.0226 -7.0824 34.8809
COR-L88 GDSC1 2.4856 11.2188 -2.6685 23.1178
NCI-H2869 GDSC1 2.4972 9.8697 -1.9911 19.8791
IA-LM GDSC1 2.5027 4.9466 0.4026 4.2375
SBC-1 GDSC1 2.508 9.5756 -1.8375 19.0398
SBC-5 GDSC1 2.5392 8.7136 -1.3892 16.4127
SHP-77 GDSC1 2.5669 5.4963 0.1872 5.6294
Lu-65 GDSC1 2.6427 8.6878 -1.3006 15.5715
DMS 79 GDSC1 2.661 8.7771 -1.331 15.7006
NCI-H345 GDSC1 2.6615 3.4681 1.0965 0.1292
NCI-H1694 GDSC1 2.6943 13.6961 -3.7372 26.5633
Calu-6 GDSC1 2.7196 4.6243 0.6697 2.0426
Lu-135 GDSC1 2.7354 9.3282 -1.547 16.7479
COR-L105 GDSC1 2.8056 11.4154 -2.5225 21.5184
NCI-H522 GDSC1 2.837 5.6338 0.2891 4.3167
NCI-H2196 GDSC1 2.8398 6.3292 -0.0295 6.528
HCC33 GDSC1 2.8553 31.7707 -12.6206 39.778
NCI-H720 GDSC1 2.8564 4.6337 0.7346 1.4698
SW1573 GDSC1 2.8565 5.636 0.2995 4.2058
NCI-H1993 GDSC1 2.8696 6.093 0.0987 5.5625
NCI-H2141 GDSC1 2.8803 17.1423 -5.3055 30.4392
NCI-H2291 GDSC1 2.9088 5.2839 0.4855 2.8802
NCI-H2804 GDSC1 2.9242 7.7886 -0.6658 10.7171
NCI-H322M GDSC1 2.9395 6.7727 -0.1737 7.3026
NCI-H1793 GDSC1 2.9839 6.5156 -0.0263 6.1758
NCI-H2110 GDSC1 3.0222 12.0376 -1.2659 26.4269
NCI-H1838 GDSC1 3.0286 4.9273 0.697 1.4562
HOP-92 GDSC1 3.0346 5.5572 1.9774 9.6749
NCI-H1648 GDSC1 3.0559 8.8166 -1.0701 12.9848
NCI-H1734 GDSC1 3.0591 10.7767 -2.0213 18.3789
COR-L95 GDSC1 3.0691 10.0661 -1.6669 16.4661
NCI-H2029 GDSC1 3.0798 4.9359 0.7174 1.2903
NCI-H1975 GDSC1 3.0865 9.8904 -1.569 15.8703
RERF-LC-MS GDSC1 3.09 4.8025 0.7749 1.0002
NCI-H841 GDSC1 3.1082 9.4627 -1.3461 14.5211
NCI-H2023 GDSC1 3.1706 6.2249 0.2159 4.1534
Calu-3 GDSC1 3.1734 10.0491 -1.5848 15.7197
NCI-H2722 GDSC1 3.2065 8.4275 -0.7819 10.7536
NCI-H1703 GDSC1 3.2119 11.0358 -0.6045 23.2414
COLO 668 GDSC1 3.2406 12.8633 -2.9124 21.9753
NCI-H2369 GDSC1 3.2516 4.6864 0.8858 0.4362
NCI-H2803 GDSC1 3.267 5.8008 0.4518 2.5135
NCI-H1437 GDSC1 3.2992 19.342 -6.0732 31.1059
NCI-H1650 GDSC1 3.315 7.3305 -0.1994 6.6284
NCI-H2172 GDSC1 3.3404 6.5202 0.1801 4.0737
NCI-H2461 GDSC1 3.387 7.5763 -0.2686 6.9348
EMC-BAC-2 GDSC1 3.393 11.649 -2.2074 18.3889
NCI-H650 GDSC1 3.4072 10.1655 -1.4786 14.4924
NCI-H2347 GDSC1 3.4724 11.7995 -2.2242 18.2586
NCI-H2373 GDSC1 3.476 5.3781 0.7195 0.8966
NCI-H513 GDSC1 3.5175 5.5442 0.6735 1.0569
NCI-H1651 GDSC1 3.5482 9.675 -1.1489 12.1956
LCLC-103H GDSC1 3.5511 12.5584 -2.5378 19.5211
NCI-H1781 GDSC1 3.5512 11.4006 -1.9752 16.8067
NCI-H727 GDSC1 3.6238 12.6266 -2.5193 19.2468
RERF-LC-Sq1 GDSC1 3.6595 13.3301 -2.8367 20.5459
NCI-H1573 GDSC1 3.6696 5.2775 0.8336 0.3795
NCI-H64 GDSC1 3.6891 4.8266 0.9944 0.0711
NCI-H1666 GDSC1 3.6931 10.0906 -1.2507 12.4461
NCI-H2030 GDSC1 3.7411 13.5357 -2.8786 20.5122
NCI-H2085 GDSC1 3.7936 14.8382 -3.4772 22.7257
NCI-H69 GDSC1 3.8384 23.6344 -7.7879 32.996
NCI-H292 GDSC1 3.8601 22.1351 -7.0274 31.6926
NCI-H290 GDSC1 3.871 13.2784 -2.6614 19.2492
NCI-H1355 GDSC1 3.8811 13.0308 -2.5343 18.6564
NCI-H2342 GDSC1 3.8868 6.2134 0.5748 1.1598
NCI-H1435 GDSC1 3.8894 5.4448 0.8557 0.2436
NCI-H661 GDSC1 3.8929 9.4118 -0.8051 9.2819
NCI-H441 GDSC1 3.9003 10.6664 -1.3878 12.7409
DMS 53 GDSC1 4.1034 5.9118 0.7711 0.359
NCI-H2009 GDSC1 4.1386 6.1419 0.7029 0.5263
NCI-H1623 GDSC1 4.262 5.8737 0.8407 0.1729
HCC15 GDSC1 4.3157 12.4473 -1.9593 14.8375
LC-1/sq GDSC1 4.3567 8.5769 1.5253 8.8926
HCC827 GDSC1 4.4464 6.1591 0.8085 0.1832
NCI-H1563 GDSC1 4.4552 11.39 0.2143 15.9338
NCI-H2444 GDSC1 4.5921 5.9468 2.8886 0.7793
NCI-H1915 GDSC1 4.6622 13.8582 -2.4009 16.1805
Lu-165 GDSC1 4.7456 14.5146 -2.6579 17.1499
NCI-H2595 GDSC1 4.7773 12.7737 -1.8157 13.0693
EKVX GDSC1 4.7894 6.7382 0.7322 0.2286
HCC44 GDSC1 5.1232 21.4472 -5.7492 26.4478
PaCa-3 GDSC1 5.2372 16.0027 -3.0401 17.6851
HOP-62 GDSC1 5.2717 20.7656 -5.3106 25.05
NCI-H2591 GDSC1 5.4077 16.014 -2.9338 16.8904
NCI-H3122 GDSC1 5.4313 18.9106 -4.3009 21.8109
NCI-H1299 GDSC1 5.5186 13.6748 -1.7772 11.3675
NCI-H1792 GDSC1 5.6372 20.088 -3.1931 25.715
NCI-H596 GDSC1 5.683 19.6247 -4.4721 21.8346
NCI-H2405 GDSC1 5.6951 14.3438 -1.9769 12.0134
RERF-LC-KJ GDSC1 6.6905 26.0731 -6.8885 26.0799
⏷ Show the Full List of 172 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1 3.0856 9.796 -1.5238 15.6158
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYSE-450 GDSC1 1.1296 8.0773 -2.195 25.5929
TE-6 GDSC1 2.176 5.9459 -0.2965 10.2228
KYSE-520 GDSC1 2.3841 5.6737 -0.0176 7.5839
KYSE-150 GDSC1 2.4418 5.7053 0.0063 7.2559
KYSE-510 GDSC1 2.5078 5.0325 0.3661 4.4858
TE-15 GDSC1 2.5823 10.3338 -2.1563 20.4525
KYSE-180 GDSC1 2.6593 6.0744 -0.0254 6.9325
TE-8 GDSC1 2.6904 5.2005 0.3992 3.8627
TE-5 GDSC1 2.8781 6.2348 0.0384 5.9637
TE-1 GDSC1 2.9803 6.4805 -0.0122 6.0865
KYSE-70 GDSC1 3.1466 6.6788 -0.0025 5.6599
OE19 GDSC1 3.1729 4.2764 1.0013 0.1663
TE-10 GDSC1 3.3875 6.6347 0.1558 4.1449
COLO 680N GDSC1 3.5898 8.7506 -0.6868 9.2176
KYSE-140 GDSC1 3.6134 12.8738 -2.6471 19.8464
TE-4 GDSC1 3.6337 5.5907 0.7049 0.8313
T.T GDSC1 3.7619 5.3156 0.8543 0.2895
OE21 GDSC1 3.9226 5.9993 0.6702 0.7569
OE33 GDSC1 3.9567 5.8994 0.7202 0.5686
TE-9 GDSC1 4.0263 5.3269 0.9426 0.0808
EC-GI-10 GDSC1 4.0277 5.5985 0.8521 0.2105
KYSE-270 GDSC1 4.4985 15.5383 -3.3176 20.4252
TE-11 GDSC1 4.7236 12.8125 -1.8678 13.4526
KYSE-410 GDSC1 4.9621 12.8246 -1.7241 12.2068
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Caov-3 GDSC1 -7.1432 10.3058 -11.2907 63.5336
A2780 GDSC1 -3.461 6.5042 -5.8447 54.2241
TOV-112D GDSC1 -1.4595 6.2319 -2.8913 48.8698
OC 314 GDSC1 -0.2575 12.6344 -4.5555 44.4478
FU-OV-1 GDSC1 1.7652 6.2451 -0.7564 14.8283
TOV-21G GDSC1 2.3971 4.2004 0.6792 2.543
Kuramochi GDSC1 2.8647 9.1673 -1.3748 15.3706
OV56 GDSC1 2.9736 4.665 0.7769 1.1104
DOV13 GDSC1 3.2913 5.1455 0.7297 1.0144
JHOS-2 GDSC1 3.3597 4.9621 0.8276 0.5664
OVCAR-4 GDSC1 3.4349 10.2507 -1.5006 14.5454
ES-2 GDSC1 3.4434 5.1217 0.8022 0.6018
OAW42 GDSC1 3.5102 9.9143 -1.2882 13.1219
Caov-4 GDSC1 3.5186 11.3802 -1.9881 16.958
TYK-nu GDSC1 3.5252 5.2035 0.8047 0.5423
IGROV-1 GDSC1 3.6415 38.6387 -15.4165 40.3097
OVCAR-5 GDSC1 3.8041 10.3445 -1.2983 12.4559
SK-OV-3 GDSC1 3.8121 10.9806 -1.5953 14.1193
OVCAR-3 GDSC1 3.8441 5.4323 0.8436 0.2847
OVK18 GDSC1 4.0905 5.87 0.7811 0.3401
RMG-I GDSC1 4.1036 13.2645 -2.493 17.9169
OVTOKO GDSC1 4.1477 10.603 -1.1996 11.0843
OAW28 GDSC1 4.5771 19.8521 -5.3642 26.6377
EFO-21 GDSC1 5.08 15.2212 -2.7727 16.9091
OVCAR-8 GDSC1 5.111 14.4595 -2.393 15.1591
OVKATE GDSC1 5.7179 16.6871 -3.0505 16.7309
OVISE GDSC1 5.7888 20.1801 -4.667 22.2146
OV-90 GDSC1 7.0396 22.0924 -4.7441 20.1046
EFO-27 GDSC1 7.1952 20.962 -4.1129 17.8424
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KP-4 GDSC1 -2.3161 20.3995 -10.2559 51.5941
HPAC GDSC1 -1.4368 6.9082 -3.1407 48.805
KP-1N GDSC1 -0.2659 17.6774 -7.009 48.8657
HuP-T4 GDSC1 0.2719 14.0707 -4.7475 42.8005
Capan-1 GDSC1 0.6298 47.9602 -22.5539 46.2187
SUIT-2 GDSC1 1.0032 4.989 0.2121 27.6471
Panc 02.03 GDSC1 1.4201 6.5026 -0.0229 26.9854
MIA PaCa-2 GDSC1 1.4233 13.6086 -4.7142 33.0853
PSN1 GDSC1 2.145 14.2802 -4.4608 30.3016
MZ-PC-1 GDSC1 2.2784 9.5546 -0.6815 26.6134
Panc 03.27 GDSC1 2.5086 10.757 -2.4218 21.9452
KP-2 GDSC1 2.6808 11.0052 -1.0448 26.6853
PaTu 8902 GDSC1 2.7227 7.3454 0.8118 17.7441
Panc 08.13 GDSC1 2.9392 4.2849 2.5109 6.6778
HPAF-II GDSC1 2.9883 11.1279 -0.8404 24.9089
KP-3 GDSC1 2.9907 6.9633 -0.2304 7.5741
PaTu 8988t GDSC1 3.0335 10.7467 -0.6114 23.8218
AsPC-1 GDSC1 3.118 6.2342 1.7142 11.0563
Capan-2 GDSC1 3.2557 6.0401 0.3436 3.187
HuP-T3 GDSC1 3.2731 10.0625 -0.0664 20.6126
BxPC-3 GDSC1 3.4267 8.2161 0.9847 14.5452
PL4 GDSC1 3.5832 4.9266 2.7512 3.2072
Panc 04.03 GDSC1 3.8429 5.6179 2.6008 3.5268
SW1990 GDSC1 3.8946 8.9317 1.0034 13.1255
Hs 766T GDSC1 3.9306 6.3506 2.3064 5.1318
YAPC GDSC1 4.1033 9.8486 0.7097 14.2289
DAN-G GDSC1 4.2658 12.735 -0.5984 20.2272
SU.86.86 GDSC1 4.3406 14.6395 -1.4875 23.5286
QGP-1 GDSC1 4.6165 17.6468 -4.2578 23.4266
Panc 10.05 GDSC1 4.8274 23.4638 -5.4994 32.2453
CFPAC-1 GDSC1 6.5464 15.1788 -0.1547 13.0888
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H2052 GDSC1 2.8516 6.173 0.0506 5.9382
MSTO-211H GDSC1 3.1238 5.1015 0.6712 1.4771
IST-Mes1 GDSC1 3.1311 6.2308 0.1909 4.3934
NCI-H28 GDSC1 3.3468 9.504 -1.202 13.0257
MPP 89 GDSC1 3.4188 5.4153 0.6805 1.1166
NCI-H2452 GDSC1 4.2041 11.5926 -1.6278 13.3598
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
VCaP GDSC1 2.141 9.4591 -2.0613 21.3642
22Rv1 GDSC1 3.0077 19.1308 -6.1951 32.0281
LNCaP clone FGC GDSC1 3.3534 10.8934 -1.8679 16.7729
PC-3 GDSC1 3.6263 14.8655 -3.6126 23.636
DU145 GDSC1 3.8036 5.5404 0.7906 0.437
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1 6.6449 18.8812 -3.4888 16.6412
Cancer Drug Sensitivity Data Curated from 56 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-431 GDSC1 -5.473 6.5462 -7.9541 62.1461
A-375 GDSC1 -3.3911 6.3713 -5.7148 53.9343
A2058 GDSC1 0.1657 6.2163 -1.1762 37.1932
Mel JuSo GDSC1 0.3099 20.6881 -9.1949 42.2217
IGR-1 GDSC1 0.5199 9.7832 -3.5731 33.1649
A101D GDSC1 1.442 5.8671 -0.8282 16.4682
Mel Ho GDSC1 1.4921 22.6156 -9.1605 39.5511
CHL-1 GDSC1 1.7467 9.6914 -2.4907 24.7189
IGR-37 GDSC1 1.8041 4.6995 0.0415 8.8275
WM1552C GDSC1 1.8805 10.2977 -2.6855 25.1132
G-mel GDSC1 1.9252 3.9305 0.5068 4.8957
MMAc-SF GDSC1 1.9981 7.3741 -1.136 16.5681
COLO 783 GDSC1 2.0101 6.5346 -0.7103 13.6955
SK-MEL-2 GDSC1 2.0868 8.3138 -1.5341 18.6911
LB2518-MEL GDSC1 2.1888 5.2458 0.054 7.5874
LOX-IMVI GDSC1 2.2384 5.9108 -0.2343 9.5839
Hs 940.T GDSC1 2.3626 4.8811 0.3452 4.974
WM115 GDSC1 2.3641 8.7088 -1.5177 17.7057
GAK GDSC1 2.5609 7.5856 -0.8206 12.7584
UACC-62 GDSC1 2.5636 4.9935 0.418 3.997
RVH-421 GDSC1 2.5735 8.2859 -1.154 14.8758
Hs 938.T GDSC1 2.5854 3.7432 2.3848 8.8053
SK-MEL-28 GDSC1 2.6234 3.7841 0.9665 0.574
MeWo GDSC1 2.6486 4.6721 0.6111 2.5287
WT2-iPS GDSC1 2.7424 4.2311 0.8441 1.0294
CP66-MEL GDSC1 2.7438 4.8495 0.5854 2.5281
M14 GDSC1 2.7721 4.61 0.7027 1.7661
SK-MEL-1 GDSC1 2.7972 4.4904 0.7648 1.3806
SK-MEL-24 GDSC1 2.8002 7.089 -0.4145 9.327
SK-MEL-5 GDSC1 2.8135 5.0835 2.007 10.2258
SK-MEL-3 GDSC1 2.8356 5.0926 2.0234 10.0484
VMRC-MELG GDSC1 2.9491 4.4096 0.8658 0.7239
G-361 GDSC1 2.9686 22.5538 -7.9307 34.987
COLO 679 GDSC1 3.0116 11.3533 -2.3388 20.0753
LB373-MEL-D GDSC1 3.0413 4.1161 1.0093 0.192
WM35 GDSC1 3.1083 14.6521 -3.894 25.9431
CP50-MEL-B GDSC1 3.1556 4.8838 0.772 0.9504
IPC-298 GDSC1 3.3886 9.4971 -1.1705 12.7278
HT-144 GDSC1 3.4027 16.0166 -4.3462 26.586
COLO 800 GDSC1 3.4725 16.1879 -4.3783 26.5056
SK-MEL-30 GDSC1 3.473 13.5577 -3.083 22.0444
451Lu GDSC1 3.6042 5.5397 0.7119 0.8263
DJM-1 GDSC1 3.6606 6.6186 0.3066 2.7854
MZ-MEL-2 GDSC1 3.7994 11.6196 -1.9098 15.8331
MZ-MEL-7 GDSC1 3.8278 16.8278 -4.4288 25.7829
SH-4 GDSC1 3.8854 13.0708 -2.5507 18.7192
RPMI-7951 GDSC1 4.1864 16.0387 -3.7809 22.8459
IST-MEL1 GDSC1 4.5003 15.3192 -3.2106 20.0066
HMV-II GDSC1 4.5335 18.6571 -4.8105 25.258
COLO 792 GDSC1 4.7417 11.2236 0.5089 13.7111
UACC-257 GDSC1 5.0039 12.8398 -1.7054 12.0236
A-388 GDSC1 5.1701 18.4989 -4.2825 22.2987
WM278 GDSC1 5.2703 17.6379 -3.7989 20.4746
COLO 829 GDSC1 6.7278 18.5501 -3.2832 15.7169
WM793 GDSC1 7.178 24.2699 -5.6875 22.4697
EquiPSC Line K2 GDSC1 3.2698 9.4739 -1.2399 13.4549
⏷ Show the Full List of 56 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1 -8.6696 0.2945 -9.3146 79.9479
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
EW-8 GDSC1 -6.2591 -5.3054 -6.2591 93.3181
STS-0421 GDSC1 -2.1439 3.2684 -3.1146 45.817
G-401 GDSC1 -2.099 3.1064 -2.5309 53.5634
G-402 GDSC1 -1.6368 4.631 -2.4875 49.9504
MES-SA GDSC1 0.4053 21.647 -9.5922 42.2868
Rh18 GDSC1 1.0852 3.6368 -0.0172 11.8355
Rh41 GDSC1 1.6368 5.4339 -0.4538 13.1119
Rh30 GDSC1 2.5132 6.5602 -0.3561 9.6855
KYM-1 GDSC1 2.5629 4.001 0.8526 1.2018
SW982 GDSC1 2.6629 16.8722 -5.3416 31.0745
VA-ES-BJ GDSC1 2.8173 5.8777 0.1659 5.2092
RKN GDSC1 2.9591 4.1414 0.9696 0.3337
SW684 GDSC1 3.0038 4.2138 0.9608 0.3372
RD GDSC1 3.1117 7.1928 -0.2611 7.5011
SK-UT-1 GDSC1 3.6026 6.1386 0.4765 1.9239
MFH-ino GDSC1 3.6611 5.9402 0.5824 1.3336
SW872 GDSC1 3.8641 10.7971 -1.4734 13.3134
GCT GDSC1 3.8649 5.3704 0.8725 0.2173
TE 441.T GDSC1 4.1174 19.1854 -5.375 27.6722
HT-1080 GDSC1 4.3027 14.5605 -2.9809 19.5503
A-204 GDSC1 4.3487 18.1264 -4.6846 25.3139
SK-LMS-1 GDSC1 5.0736 18.81 -4.5003 23.1798
Hs 633.T GDSC1 5.1987 14.1479 -2.1914 14.0325
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HSC-39 GDSC1 -1.1888 6.6515 -3.6265 40.8483
MKN7 GDSC1 -0.9126 2.4037 -1.468 31.7295
IM95 GDSC1 -0.3549 11.2984 -4.0137 44.3597
RERF-GC-1B GDSC1 -0.3398 7.6196 -3.281 35.8944
HGC-27 GDSC1 -0.1425 87.826 -43.1339 48.4399
ECC10 GDSC1 0.743 21.1501 -9.0564 41.1158
MKN1 GDSC1 1.6604 14.9022 -5.165 33.4025
SCH GDSC1 2.6942 3.9377 0.9379 0.6355
GCIY GDSC1 2.7041 5.2775 0.3724 4.0187
NUGC-3 GDSC1 2.7949 8.5531 -1.1252 14.0516
23132/87 GDSC1 2.8519 4.7291 0.6929 1.7095
SNU-16 GDSC1 3.0258 11.5802 -2.4399 20.5077
NUGC-4 GDSC1 3.0417 5.1819 0.5983 1.9858
Fu97 GDSC1 3.3257 10.926 -0.4541 22.2434
RF-48 GDSC1 3.3639 13.7091 -3.2374 22.9371
OCUM-1 GDSC1 3.4165 7.7515 -0.3312 7.2863
SNU-5 GDSC1 3.481 5.0007 0.8609 0.3914
TGBC11TKB GDSC1 3.6541 5.4988 0.7474 0.6585
MKN28 GDSC1 3.6737 9.096 -0.795 9.7117
NCI-N87 GDSC1 3.9959 7.095 0.2739 2.5144
SNU-1 GDSC1 4.4589 16.5226 -3.8226 22.3514
TMK-1 GDSC1 4.4795 6.3292 0.7624 0.2544
MKN45 GDSC1 4.7136 14.1646 -2.5125 16.5743
Hs 746.T GDSC1 5.9395 15.4349 -2.3294 13.2009
AGS GDSC1 6.819 17.1916 -2.6052 12.8182
SNG-M GDSC1 1.1557 10.7739 -3.5208 30.6813
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IHH-4 GDSC1 -0.5028 5.4467 -1.566 41.7567
KMH-2 GDSC1 0.65 5.5547 -0.3922 32.0402
TT2609-C02 GDSC1 1.0892 55.0375 -25.7073 46.2146
HTC-C3 GDSC1 2.2898 5.291 0.102 6.9528
CGTH-W-1 GDSC1 2.6702 5.2663 0.3573 4.1932
BHT-101 GDSC1 2.7099 6.4593 -0.1746 7.8712
K5 GDSC1 2.7596 4.7773 0.6251 2.2529
ASH-3 GDSC1 2.8709 5.1896 2.0092 10.0158
CAL-62 GDSC1 2.9855 4.7806 0.7361 1.3031
FTC-133 GDSC1 3.4461 4.93 0.8729 0.374
8305C GDSC1 3.487 10.0532 -1.3703 13.6615
TT GDSC1 3.5859 5.0376 0.887 0.278
WRO GDSC1 3.5868 5.3119 0.7894 0.5566
ML-1 [Human leukemia] GDSC1 3.7373 13.1496 -1.2267 24.1916
8505C GDSC1 4.2809 16.2811 -3.8316 22.7965
B-CPAP GDSC1 5.2878 17.8321 -3.8803 20.72
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PCI-06A GDSC1 -9.1056 16.0615 -15.853 63.6133
OSC-20 GDSC1 -0.6627 12.3865 -4.8283 46.1051
HO-1-N-1 GDSC1 -0.5924 35.5221 -17.3766 46.899
JHU-011 GDSC1 -0.5004 106.4397 -52.7406 48.8998
UPCI-SCC-090 GDSC1 -0.0502 13.7152 -6.0312 40.1153
CAL-33 GDSC1 0.1163 42.1365 -20.0763 46.4111
NCI-H3118 GDSC1 1.2864 5.8737 0.1275 26.8232
SCC-15 GDSC1 1.9378 11.9317 -2.1643 32.7509
PCI-15A GDSC1 2.2513 7.4191 -0.9655 14.6505
SAS GDSC1 2.6013 7.8382 -0.9148 13.2636
PCI-30 GDSC1 2.7818 3.5004 2.6848 6.2641
SCC-25 GDSC1 2.8539 20.8589 -7.1769 34.1112
PCI-38 GDSC1 2.8858 6.3807 -0.0245 6.3863
BB49-HNC GDSC1 2.9706 7.0252 -0.2724 7.9129
SCC-4 GDSC1 2.9784 6.6454 -0.0898 6.6281
OSC-19 GDSC1 3.0946 9.1899 -1.2236 13.8242
KON GDSC1 3.1536 5.3006 0.6041 1.8007
HSC-2 GDSC1 3.2156 4.7073 0.864 0.5315
SAT [Human HNSCC] GDSC1 3.2968 8.814 -0.9059 11.3211
LB771-HNC GDSC1 3.3496 8.4534 -0.7005 9.8715
FaDu GDSC1 3.3543 7.7033 -0.3471 7.5293
BICR 22 GDSC1 3.4456 4.9523 0.8648 0.3977
HSC-3 GDSC1 3.4741 4.9071 0.8915 0.3109
CAL-27 GDSC1 3.5878 26.1974 -9.2571 35.4731
DOK GDSC1 3.6026 6.0589 0.5087 1.7565
PCI-04B GDSC1 3.6301 18.7113 -5.5069 29.0993
Ca9-22 GDSC1 3.687 6.1965 0.4926 1.7423
HO-1-u-1 GDSC1 3.7081 14.3499 -1.8502 26.4424
Detroit 562 GDSC1 3.7135 10.3659 -1.368 13.0799
SKN-3 GDSC1 4.0943 10.0062 -0.9558 9.7609
BICR 10 GDSC1 4.1126 5.764 0.8256 0.237
BICR 78 GDSC1 4.1629 6.7769 0.4766 1.3409
SCC-9 GDSC1 4.2836 18.3613 -4.8472 25.9189
BB30-HNC GDSC1 4.9498 19.3295 -4.8402 24.4397
HSC-4 GDSC1 5.1227 10.9731 0.9004 10.7435
JHU-022 GDSC1 5.3385 15.3958 -2.6871 15.9911
BICR 31 GDSC1 5.7214 14.431 -2.001 12.0795
PE/CA-PJ15 GDSC1 6.4203 16.8672 -1.0476 17.1094
BHY GDSC1 7.3682 22.2635 -4.6125 19.1336
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
5637 GDSC1 -7.9546 10.5276 -12.2236 65.0237
RT-112 GDSC1 -4.0776 7.5788 -6.9489 56.4196
BFTC-905 GDSC1 0.93 27.8869 -12.2661 42.8307
RT-4 GDSC1 1.9615 11.5116 -1.9351 32.0353
HT-1376 GDSC1 2.0297 4.0096 1.6894 15.1252
KU-19-19 GDSC1 2.0618 5.8424 -0.3295 10.8107
SW780 GDSC1 2.318 3.903 0.7668 2.1093
639V GDSC1 2.4396 7.4684 -0.8508 13.3168
SW1710 GDSC1 2.58 7.4248 -0.7286 12.0864
CAL-29 GDSC1 3.1876 5.1756 0.6711 1.4031
TCCSUP GDSC1 3.481 8.1405 -0.4712 8.0667
HT-1197 GDSC1 3.5029 5.2535 0.7774 0.6513
J82 GDSC1 3.8857 6.1847 0.5852 1.1163
UM-UC-3 GDSC1 4.0876 12.7675 -2.2649 16.889
647V GDSC1 5.1417 13.9021 -2.1126 13.7742
T24 GDSC1 5.329 12.1723 -1.2098 8.7638
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BPH-1 GDSC1 -5.7677 1.9923 -6.6009 69.0995
SW954 GDSC1 -5.3907 4.116 -6.9096 64.4365
Ca Ski GDSC1 -2.8161 30.1196 -16.6352 50.2856
PA-1 GDSC1 -1.2476 13.8381 -7.1685 45.0707
KGN GDSC1 -0.0858 9.5084 -3.9763 36.6114
SKN GDSC1 1.3175 3.2627 1.1561 21.2292
JAR GDSC1 1.6447 4.6038 -0.0339 9.9259
NEC8 GDSC1 1.7696 3.7642 0.4769 5.5714
ACC-OV7 GDSC1 2.1662 9.2661 -1.9457 20.6902
SKG-IIIa GDSC1 2.507 4.6277 0.5508 3.1969
JHOS-3 GDSC1 2.518 5.9769 -0.0724 7.6302
OMC-1 [Human cervical carcinoma] GDSC1 2.5227 6.4055 -0.2749 9.079
NT2-D1 GDSC1 2.7133 6.2243 -0.0611 7.055
NCC-IT GDSC1 2.7605 8.3306 -1.0413 13.6211
HEY GDSC1 2.7962 8.1413 -0.9241 12.7687
C-33 A GDSC1 2.9106 10.0315 -1.7642 17.4483
OVMIU GDSC1 2.9213 7.645 -0.5989 10.2746
DSH1 GDSC1 2.9361 6.162 0.1074 5.3567
HEC-1 GDSC1 3.0826 4.6164 0.8435 0.7063
JEG-3 GDSC1 3.0878 4.5102 0.8855 0.5392
SW962 GDSC1 3.1028 5.9868 0.2834 3.838
LB831-BLC GDSC1 3.1189 9.0945 -1.1607 13.3757
SiHa GDSC1 3.1541 4.4043 0.9498 0.2956
OVCA420 GDSC1 3.2219 5.2738 0.6476 1.4842
HT-3 GDSC1 3.377 5.7913 0.5105 2.0246
DoTc2 4510 GDSC1 3.3936 6.6824 0.1382 4.2467
ME-180 GDSC1 3.4519 15.1694 -3.8912 25.0347
OV17R GDSC1 3.4977 8.1896 -0.4836 8.1107
SW756 GDSC1 3.5647 5.2152 0.8158 0.4838
MS751 GDSC1 3.8433 7.1391 0.18 3.2521
CAL-39 GDSC1 3.9999 10.5563 -1.2715 11.838
OVCA433 GDSC1 4.011 10.5041 -1.2399 11.6289
PEO1 GDSC1 4.0176 12.3344 -2.1046 16.279
C-4-I GDSC1 4.3038 12.9567 -2.2096 16.1048
UWB1.289 GDSC1 4.4784 9.5683 -0.5325 6.4507
SiSo GDSC1 4.8092 16.0368 -3.3439 19.8175
HeLa GDSC1 4.9208 12.662 -1.6744 12.0342
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8358).
2 Discovery of GSK1070916, a potent and selective inhibitor of Aurora B/C kinase. J Med Chem. 2010 May 27;53(10):3973-4001.