Details of the Drug

General Information of Drug (ID: DMXSEHF)

Drug Name
Y-39983
Synonyms RKI-983; SNJ-1656; ROCK inhibitors, Mitsubishi Tanabe Pharma/Senju/Novartis; Rho-associated protein kinase inhibitors, Mitsubishi Tanabe Pharma/Senju/Novartis
Indication
Disease Entry ICD 11 Status REF
Glaucoma/ocular hypertension 9C61 Phase 1/2 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 280.32
Logarithm of the Partition Coefficient (xlogp) 1.4
Rotatable Bond Count (rotbonds) 3
Hydrogen Bond Donor Count (hbonddonor) 3
Hydrogen Bond Acceptor Count (hbondacc) 3
Chemical Identifiers
Formula
C16H16N4O
IUPAC Name
4-[(1R)-1-aminoethyl]-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzamide
Canonical SMILES
C[C@H](C1=CC=C(C=C1)C(=O)NC2=C3C=CNC3=NC=C2)N
InChI
InChI=1S/C16H16N4O/c1-10(17)11-2-4-12(5-3-11)16(21)20-14-7-9-19-15-13(14)6-8-18-15/h2-10H,17H2,1H3,(H2,18,19,20,21)/t10-/m1/s1
InChIKey
JTVBXQAYBIJXRP-SNVBAGLBSA-N
Cross-matching ID
PubChem CID
9810884
ChEBI ID
CHEBI:91412
CAS Number
199433-58-4
TTD ID
D0U9LT
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Rho-associated protein kinase (ROCK) TTMQO60 NOUNIPROTAC Modulator [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1 5.7118 15.6495 -0.2293 24.4854
CHSA8926 GDSC1 -0.4879 13.6654 -4.7826 53.042
EW-13 GDSC1 1.0037 5.4743 0.3315 43.597
EW-7 GDSC1 2.2408 6.3967 1.2759 31.7936
ES7 GDSC1 3.0597 6.8538 1.8951 23.8295
CADO-ES1 GDSC1 3.4549 5.0759 3.1002 13.318
ES8 GDSC1 3.5372 8.4897 1.5526 23.7346
ES1 GDSC1 4.1136 6.6168 2.9965 11.2176
ES6 GDSC1 4.3653 8.7421 2.1479 16.5539
EW-1 GDSC1 4.4031 5.8354 3.6318 5.1561
ES4 GDSC1 4.421 7.0885 3.0203 9.893
TC-71 GDSC1 4.4216 6.8944 3.1178 9.1316
EW-18 GDSC1 4.5774 9.2817 2.0516 16.441
ES5 GDSC1 4.5988 10.0558 1.6823 18.7476
SK-PN-DW GDSC1 4.6257 7.2091 3.1231 8.3978
SK-ES-1 GDSC1 4.6548 6.7363 3.3797 6.3077
NOS-1 [Human HNSCC] GDSC1 4.7383 6.417 3.5978 4.3675
SJSA-1 GDSC1 5.0937 10.1917 2.0028 15.0243
MHH-ES-1 GDSC1 5.0977 9.1835 2.5034 11.559
A-673 GDSC1 5.1252 6.6643 3.7331 2.4155
HuO-3N1 GDSC1 5.2541 11.1122 1.6689 16.6322
EW-3 GDSC1 5.2832 7.5225 3.4342 4.1872
HOS GDSC1 5.3899 7.7004 3.4181 4.06
EW-16 GDSC1 5.4335 9.3679 2.6545 9.491
EW-24 GDSC1 5.5438 7.9017 3.4187 3.7241
H-EMC-SS GDSC1 5.6583 11.0839 1.9795 13.4637
CAL-78 GDSC1 5.7144 13.1815 0.9923 19.03
G-292 clone A141B1 GDSC1 5.728 9.988 2.5577 9.3818
U2OS GDSC1 6.1819 12.434 1.6918 13.8009
MG-63 GDSC1 6.4466 8.1477 3.7608 0.603
CAL-72 GDSC1 6.4795 8.0395 3.813 0.4152
CHSA0011 GDSC1 6.6205 8.9261 3.5375 1.39
CHSA0108 GDSC1 6.666 8.997 3.5299 1.3802
NY GDSC1 6.9657 9.2233 3.5712 0.9441
SaOS-2 GDSC1 7.3713 8.9785 3.8093 0.1403
HuO9 GDSC1 7.4042 9.4222 3.6694 0.3936
EW-11 GDSC1 7.9062 10.2577 3.5615 0.4615
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 144 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC1 4.1321 9.6057 1.5203 21.467
SR GDSC1 -2.2775 -0.9847 -2.2775 81.8418
ST486 GDSC1 -2.124 3.2433 -2.4502 69.7098
Ku812 GDSC1 -1.2516 0.9401 -1.2591 68.6664
SU-DHL-5 GDSC1 -0.6152 3.9373 -0.9662 58.6804
BE-13 GDSC1 -0.3635 2.9014 -0.4853 57.4485
GDM-1 GDSC1 -0.1787 6.7441 -1.4125 53.5075
NALM-6 GDSC1 0.2059 4.445 -0.2042 51.1262
EoL-1 GDSC1 0.4374 4.1525 0.1276 48.8047
P30/OHK GDSC1 0.5256 4.1401 0.2271 47.8666
SU-DHL-8 GDSC1 0.5974 7.2424 -0.793 48.0062
MOLM-13 GDSC1 0.6453 5.7151 -0.1416 47.1735
WSU-NHL GDSC1 0.6604 12.9483 -3.3245 48.5486
OCI-AML-2 GDSC1 0.9486 5.3765 0.3068 44.0793
ML-2 GDSC1 1.0045 10.2438 -1.7136 46.2292
SU-DHL-16 GDSC1 1.1912 2.5618 1.183 39.1821
SIG-M5 GDSC1 1.3407 3.8271 1.1889 38.0794
BL-41 GDSC1 1.355 4.7857 0.9464 39.0449
Ramos.2G6.4C10 GDSC1 1.6418 5.6484 0.9518 37.0194
P32/ISH GDSC1 1.6616 6.051 0.8146 37.4372
PL-21 GDSC1 1.6902 8.2806 -0.1252 40.144
MV4-11 GDSC1 1.9083 5.128 1.4309 32.996
RPMI-8402 GDSC1 1.9726 8.719 -0.0471 38.3737
JSC-1 GDSC1 2.5223 7.4281 1.0972 31.1155
NOMO-1 GDSC1 2.5672 10.7234 -0.4374 36.5013
NU-DUL-1 GDSC1 2.6678 5.9845 1.895 25.8387
U-698-M GDSC1 2.6732 5.8975 1.9381 25.5323
MY-M12 GDSC1 2.7457 11.3913 -0.5992 36.1441
VAL GDSC1 2.827 5.4968 2.2678 22.508
HH [Human lymphoma] GDSC1 2.8486 5.1746 2.4213 21.3274
CESS GDSC1 2.96 7.1882 1.6402 25.9082
SU-DHL-10 GDSC1 3.0754 4.8815 2.7762 17.6177
CCRF-CEM GDSC1 3.0957 7.6105 1.5701 25.6603
DND-41 GDSC1 3.1269 6.782 1.9947 22.8502
MOLT-13 GDSC1 3.1638 7.0767 1.8909 23.3522
CA46 GDSC1 3.1878 9.4856 0.7431 29.4947
Karpas-45 GDSC1 3.3148 9.9495 0.6303 29.4274
A3/Kawakami GDSC1 3.3241 4.9518 3.0139 14.6119
SUP-HD1 GDSC1 3.3493 5.834 2.6559 17.1177
KE-37 GDSC1 3.3609 9.3061 0.9897 27.5607
NB4 GDSC1 3.4015 4.7656 3.169 13.0938
SUP-M2 GDSC1 3.4252 5.5154 2.8771 15.1148
QIMR-WIL GDSC1 3.4365 7.0726 2.1535 20.3246
Namalwa GDSC1 3.4446 9.7718 0.8353 27.9364
U266B1 GDSC1 3.4459 6.4857 2.4449 18.2142
WIL2 NS GDSC1 3.4984 10.0431 0.7491 28.1049
EB2 GDSC1 3.5158 7.6029 1.9692 21.2154
Karpas-620 GDSC1 3.5219 7.4523 2.0485 20.6579
YT GDSC1 3.6042 5.1362 3.2283 11.6331
SU-DHL-6 GDSC1 3.6164 4.8838 3.3494 10.679
Loucy GDSC1 3.6391 8.134 1.8207 21.6418
Mono-Mac-6 GDSC1 3.6656 6.726 2.537 16.5602
ALL-PO GDSC1 3.7061 5.7017 3.0697 12.3553
MOLP-8 GDSC1 3.7467 4.3967 3.6722 7.6852
DEL GDSC1 3.7482 11.0103 0.4883 28.226
Farage GDSC1 3.7545 14.2104 -1.1028 33.5572
KMS-12-BM GDSC1 3.7639 6.2021 2.8841 13.5194
NKM-1 GDSC1 3.7721 6.4209 2.7851 14.239
BC-1 GDSC1 3.7744 6.3351 2.8292 13.8937
BALL-1 GDSC1 3.803 7.2519 2.4048 16.9442
Sc-1 GDSC1 3.8248 4.6803 3.6522 7.4116
RPMI-8866 GDSC1 3.8338 6.807 2.6524 14.9831
MLMA GDSC1 3.8551 5.0916 3.5021 8.3825
MOLT-4 GDSC1 3.9033 7.3458 2.4484 16.211
RPMI-6666 GDSC1 3.9039 5.9702 3.1279 11.0453
Reh GDSC1 3.9074 5.7683 3.2297 10.242
Karpas-299 GDSC1 3.9166 4.876 3.6623 6.8845
MHH-PREB-1 GDSC1 3.9387 6.8931 2.7045 14.1572
OCI-AML-5 GDSC1 3.9397 7.7028 2.3032 17.1122
SU-DHL-4 GDSC1 3.9669 5.1118 3.6026 7.1044
TUR GDSC1 4.0356 5.0677 3.69 6.1278
Jiyoye GDSC1 4.0407 7.6319 2.4271 15.8132
AMO1 GDSC1 4.0469 6.9592 2.7676 13.2433
KG-1 GDSC1 4.0729 6.7943 2.8725 12.3364
BV-173 GDSC1 4.0814 6.3424 3.1048 10.5006
PF-382 GDSC1 4.0815 9.2122 1.6737 20.7395
L-363 GDSC1 4.151 5.2376 3.7149 5.4449
KCL-22 GDSC1 4.1513 7.3856 2.6457 13.7614
ATN-1 GDSC1 4.1693 5.8843 3.4101 7.7633
KOPN-8 GDSC1 4.182 5.2686 3.7274 5.2213
BC-3 GDSC1 4.1915 5.1807 3.7796 4.7745
SK-MM-2 GDSC1 4.1988 11.3754 0.692 25.5705
OCI-Ly19 GDSC1 4.212 6.6756 3.0523 10.4065
SUP-B15 GDSC1 4.2382 5.3013 3.7608 4.7379
EJM GDSC1 4.2728 5.4044 3.7392 4.7766
WSU-DLCL2 GDSC1 4.311 5.0515 3.948 2.9891
RL GDSC1 4.3213 5.1592 3.9028 3.3081
THP-1 GDSC1 4.325 7.0772 2.9468 10.8077
OPM-2 GDSC1 4.3351 9.2853 1.8512 18.6459
Hs 445 GDSC1 4.3487 6.3966 3.3068 7.9077
HC-1 GDSC1 4.3545 5.4907 3.7645 4.2796
CTV-1 GDSC1 4.3548 9.7779 1.6213 20.0119
TK [Human B-cell lymphoma] GDSC1 4.3603 11.599 0.7153 24.864
MOLT-16 GDSC1 4.366 6.7247 3.157 9.0215
Daudi GDSC1 4.3885 6.3293 3.3732 7.2438
697 GDSC1 4.4169 11.9232 0.6002 25.1919
MC116 GDSC1 4.4189 5.5839 3.7698 4.0157
ARH-77 GDSC1 4.4633 7.4103 2.8939 10.722
LC4-1 GDSC1 4.4927 6.118 3.5619 5.4036
P12-Ichikawa GDSC1 4.5206 6.6083 3.3398 7.0538
JVM-3 GDSC1 4.5673 7.6123 2.8765 10.4968
ALL-SIL GDSC1 4.5787 17.7262 -2.1674 33.4707
VL51 GDSC1 4.5901 9.1711 2.117 15.9529
HT GDSC1 4.5937 12.2578 0.5781 24.6657
L-540 GDSC1 4.6015 7.6295 2.895 10.239
A4/Fukuda GDSC1 4.608 8.5419 2.4454 13.5783
Raji GDSC1 4.6551 7.4269 3.0376 8.9637
JJN-3 GDSC1 4.6562 5.9944 3.7452 3.4711
SUP-T1 GDSC1 4.7458 6.674 3.4777 5.2703
OCI-M1 GDSC1 4.759 6.245 3.6957 3.5622
HEL GDSC1 4.7678 7.2703 3.2008 7.3443
SCC-3 GDSC1 4.7773 6.032 3.8101 2.6545
ROS-50 GDSC1 4.7848 6.6208 3.5317 4.7424
RPMI-8226 GDSC1 4.7915 7.5716 3.0699 8.2796
CTB-1 GDSC1 4.878 21.2632 -3.6898 35.5001
KY821 GDSC1 4.9376 6.724 3.5871 3.9076
L-1236 GDSC1 4.9673 9.2848 2.3556 13.0218
DB GDSC1 4.9675 14.1968 -0.0884 26.2052
DG-75 GDSC1 4.999 6.8603 3.5629 3.932
Karpas-422 GDSC1 5.0397 9.3842 2.3612 12.7517
P31/FUJ GDSC1 5.1417 7.0194 3.5798 3.4646
LP-1 GDSC1 5.2178 7.4064 3.447 4.2484
KMOE-2 GDSC1 5.2196 6.8723 3.6944 2.4897
OCI-AML-3 GDSC1 5.255 8.9623 2.7259 9.4777
JURL-MK1 GDSC1 5.3216 9.5285 2.4974 10.9308
EM-2 GDSC1 5.403 16.7054 -0.9935 28.0098
MEG-01 GDSC1 5.4432 7.7268 3.4384 3.7997
JVM-2 GDSC1 5.482 10.5263 2.1254 13.0207
KMS-11 GDSC1 5.6222 11.2607 1.8674 14.2821
K-562 GDSC1 5.6287 8.4094 3.2373 4.8088
MN-60 GDSC1 5.7735 8.6839 3.1991 4.7612
GR-ST GDSC1 5.7751 8.4149 3.3221 3.9152
ME1 GDSC1 6.0058 7.4485 3.842 0.6085
Granta-519 GDSC1 6.042 8.4762 3.4426 2.657
SU-DHL-1 GDSC1 6.0976 7.2948 3.9339 0.2569
HAL-01 GDSC1 6.1819 9.6075 3.0212 5.1274
RS4;11 GDSC1 6.2439 16.8032 -0.3984 23.6445
KM-H2 GDSC1 6.2643 12.6039 1.6665 13.7334
LAMA-84 GDSC1 6.535 8.2593 3.7549 0.568
HDLM-2 GDSC1 6.8124 8.7118 3.6988 0.5896
L-428 GDSC1 6.8938 8.5276 3.7949 0.2879
RC-K8 GDSC1 6.9076 8.4431 3.8289 0.2134
H9 GDSC1 6.9611 16.5623 0.2373 19.2316
HL-60 GDSC1 7.172 19.2902 -0.9404 23.2259
⏷ Show the Full List of 144 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OACP4 C GDSC1 2.1717 6.8899 0.9887 33.5716
ESO-26 GDSC1 2.8157 7.0562 1.5604 27.1076
OACM5.1 C GDSC1 4.7512 11.3611 1.1534 21.2621
KYSE-50 GDSC1 4.9053 6.9467 3.4582 4.9659
KYAE-1 GDSC1 5.0282 6.8573 3.5835 3.7075
FLO-1 GDSC1 5.396 10.1186 2.2626 12.3486
TE-12 GDSC1 5.6888 8.5323 3.2174 4.8165
KYSE-220 GDSC1 6.266 8.2592 3.6414 1.2574
SK-GT-4 GDSC1 6.323 8.4144 3.6057 1.3713
ESO-51 GDSC1 6.3317 8.3775 3.6242 1.272
HCE-4 GDSC1 6.5137 8.424 3.685 0.8401
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1 4.9271 9.0007 2.4658 12.3658
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
GI-ME-N GDSC1 0.1888 8.2736 -1.6547 50.8245
CHP-134 GDSC1 1.5587 3.4926 1.4856 34.9783
IMR-5 GDSC1 1.6326 5.2521 1.0891 36.4888
KP-N-YS GDSC1 1.8746 5.6014 1.2183 34.3
SJNB-14 GDSC1 2.8056 5.5228 2.2347 22.8491
Kelly GDSC1 2.8553 4.1871 2.756 18.9787
MHH-NB-11 GDSC1 3.1353 8.4062 1.2226 27.407
TGW GDSC1 3.4391 6.1293 2.6074 17.0539
SJNB-6 GDSC1 3.9052 6.7487 2.7459 13.9801
NB(TU)1 GDSC1 4.005 8.9707 1.7285 20.7033
SJNB-13 GDSC1 4.0503 7.8695 2.317 16.5708
NB69 GDSC1 4.4007 7.7876 2.6543 12.7682
NB1 GDSC1 4.4692 7.8395 2.6843 12.2973
SJNB-7 GDSC1 4.5501 7.5291 2.9043 10.3422
SK-N-DZ GDSC1 4.6768 7.9015 2.8187 10.5695
CHP-126 GDSC1 4.6794 6.1737 3.6744 3.9485
GOTO GDSC1 4.6888 7.0734 3.2387 7.2968
NH-12 GDSC1 4.934 6.6126 3.6377 3.5403
SJNB-17 GDSC1 5.0397 9.5331 2.2877 13.2668
SiMa GDSC1 5.0993 7.0987 3.5157 4.0322
SJNB-12 GDSC1 5.4643 7.7842 3.4248 3.8501
SJNB-10 GDSC1 5.6563 9.4777 2.7533 8.19
SK-N-BE(2)-M17 GDSC1 5.6832 7.7059 3.5845 2.3623
KP-N-YN GDSC1 6.0103 14.136 0.741 19.4347
SK-N-MC-IXC GDSC1 6.1591 7.2339 3.9772 0.1413
SJNB-5 GDSC1 6.2766 7.798 3.8217 0.4997
SK-N-SH GDSC1 6.3271 8.6706 3.5042 1.8922
SK-N-FI GDSC1 6.3745 8.6575 3.5321 1.6861
LA-N-6 GDSC1 6.417 8.0906 3.77 0.5896
SK-N-AS GDSC1 6.467 8.131 3.775 0.5415
CHP-212 GDSC1 6.5514 11.3284 2.4563 8.0845
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC1 5.017 6.6659 3.6662 3.1299
Cancer Drug Sensitivity Data Curated from 51 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OCUB-M GDSC1 3.7746 7.2688 2.3708 17.3095
HCC1599 GDSC1 3.8585 8.0198 2.0739 19.0442
HCC70 GDSC1 3.8933 4.8317 3.6584 7.0251
Evsa-T GDSC1 4.1461 5.082 3.787 4.9021
HCC1187 GDSC1 4.2132 7.8644 2.4592 14.9098
CAL-120 GDSC1 4.2529 8.3407 2.2547 16.2296
CAL-85-1 GDSC1 4.5101 6.7869 3.2425 7.8509
BT-483 GDSC1 4.6327 5.9802 3.7353 3.6149
DU4475 GDSC1 4.6951 7.4342 3.0648 8.6234
EFM-19 GDSC1 4.7502 7.7393 2.9557 9.2858
HCC1806 GDSC1 4.7552 10.7465 1.4632 19.5128
MRK-nu-1 GDSC1 4.7747 7.3264 3.1783 7.4965
MDA-MB-436 GDSC1 4.861 7.2807 3.2642 6.5748
MDA-MB-468 GDSC1 5.1174 7.2894 3.4373 4.5654
BT-474 GDSC1 5.1412 8.4616 2.8888 8.6034
HCC1500 GDSC1 5.2363 6.9668 3.6614 2.6823
BT-549 GDSC1 5.2707 9.2792 2.5826 10.4713
CAMA-1 GDSC1 5.2879 7.5074 3.4442 4.1044
HCC38 GDSC1 5.295 8.088 3.1751 6.0546
CAL-148 GDSC1 5.3018 10.4594 2.0265 14.2159
Hs 578T GDSC1 5.3714 7.979 3.2766 5.121
HDQ-P1 GDSC1 5.6479 7.5078 3.6511 2.0062
HCC1428 GDSC1 5.6508 7.2985 3.741 1.4716
MDA-MB-157 GDSC1 5.6967 7.7423 3.5759 2.3936
JIMT-1 GDSC1 5.7077 7.1039 3.8466 0.8498
AU565 GDSC1 5.7111 11.3873 1.8694 14.0129
BT-20 GDSC1 5.7504 9.6077 2.7537 7.9492
HCC1395 GDSC1 5.8322 10.5579 2.3551 10.4988
MDA-MB-330 GDSC1 5.8356 8.8315 3.1689 4.8384
EFM-192A GDSC1 5.836 7.4536 3.766 1.1077
MDA-MB-361 GDSC1 5.8432 7.4625 3.7658 1.1007
UACC-893 GDSC1 5.8921 8.1776 3.4919 2.5948
HCC1569 GDSC1 5.9161 9.0069 3.1369 4.8886
HCC2218 GDSC1 6.0017 8.5053 3.4086 2.9338
ZR-75-30 GDSC1 6.1445 7.8431 3.7503 0.8739
MDA-MB-175-VII GDSC1 6.2327 8.0666 3.7021 1.0071
HCC1419 GDSC1 6.2455 7.9177 3.7646 0.7309
COLO 824 GDSC1 6.3134 12.4381 1.7796 12.9285
HCC1937 GDSC1 6.3471 8.3041 3.6599 1.0904
MDA-MB-453 GDSC1 6.3865 8.3855 3.6455 1.1186
YMB-1-E GDSC1 6.3973 9.9921 2.9727 5.025
HCC202 GDSC1 6.4976 8.245 3.7453 0.6245
MDA-MB-415 GDSC1 6.5813 8.2978 3.7591 0.5271
MCF-7 GDSC1 6.5943 8.2683 3.7748 0.4706
UACC-812 GDSC1 6.6187 8.4433 3.7206 0.6334
MFM-223 GDSC1 6.637 8.577 3.6784 0.7741
HCC2157 GDSC1 6.6825 8.4293 3.7507 0.4975
HCC1954 GDSC1 6.7797 8.6882 3.6946 0.6229
T-47D GDSC1 7.028 8.9467 3.6972 0.4814
MDA-MB-231 GDSC1 7.0369 9.1287 3.6349 0.6679
CAL-51 GDSC1 7.1267 8.6836 3.8241 0.1675
⏷ Show the Full List of 51 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 54 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
D-566MG GDSC1 2.8971 6.8866 1.7198 25.7422
U-251MG GDSC1 2.9014 7.5985 1.3888 27.6453
MOG-G-CCM GDSC1 3.2523 7.9702 1.5444 25.0701
GI-1 GDSC1 3.4818 11.3973 0.0618 30.9862
M059J GDSC1 3.5759 7.1157 2.2633 18.934
D-423MG GDSC1 3.7756 10.801 0.6165 27.5572
D-336MG GDSC1 3.8724 6.7736 2.7039 14.4336
D-247MG GDSC1 3.8798 7.0473 2.5753 15.3692
KS-1 [Human Krukenberg tumour] GDSC1 4.2239 8.1045 2.3484 15.6729
SNB-75 GDSC1 4.2297 7.8213 2.4948 14.5859
PFSK-1 GDSC1 4.304 7.5292 2.7033 12.7506
GB-1 GDSC1 4.4848 15.7038 -1.2339 31.479
DK-MG GDSC1 4.5408 5.7957 3.7585 3.7108
LN-18 GDSC1 4.5828 5.5698 3.8998 2.4949
AM-38 GDSC1 4.6854 8.2611 2.6464 11.8362
KALS-1 GDSC1 4.6872 8.2683 2.6443 11.8461
Daoy GDSC1 4.7094 5.9754 3.7916 2.9704
KNS-42 GDSC1 4.7408 5.8211 3.8861 2.1833
SF295 GDSC1 4.7625 8.4059 2.6345 11.6687
SF268 GDSC1 4.8892 10.3196 1.7818 17.1208
YKG-1 GDSC1 4.9884 8.7051 2.658 10.7725
LN-405 GDSC1 4.9914 7.2323 3.3799 5.3239
SF126 GDSC1 5.1336 8.8943 2.6719 10.2283
D-502MG GDSC1 5.2222 7.1646 3.5624 3.4072
SK-MG-1 GDSC1 5.2262 8.4708 2.9442 7.9502
GaMG GDSC1 5.2324 9.218 2.5849 10.5667
A-172 GDSC1 5.3008 8.4155 3.0223 7.1684
MOG-G-UVW GDSC1 5.3654 7.4246 3.5298 3.3264
YH-13 GDSC1 5.3689 10.6921 1.9617 14.4337
NMC-G1 GDSC1 5.4187 7.0627 3.7216 1.9428
D-263MG GDSC1 5.4819 8.3599 3.1684 5.6394
LNZTA3WT4 GDSC1 5.5308 8.8848 2.9522 7.0829
D-542MG GDSC1 5.5572 9.1951 2.822 7.9549
DBTRG-05MG GDSC1 5.6021 9.2358 2.8326 7.7631
SF539 GDSC1 5.6296 10.2201 2.3787 10.8859
KINGS-1 GDSC1 5.7574 9.1405 2.978 6.3466
42-MG-BA GDSC1 5.7919 10.1882 2.5049 9.5802
T98G GDSC1 5.8876 9.4121 2.9332 6.3598
CAS-1 GDSC1 5.9222 7.2815 3.8703 0.5611
Becker GDSC1 5.9517 9.9001 2.7459 7.513
Onda 11 GDSC1 5.9622 9.9236 2.7415 7.5181
8-MG-BA GDSC1 5.9964 10.1881 2.6393 8.1411
KNS-81-FD GDSC1 6.0274 9.6987 2.8869 6.3652
SW1783 GDSC1 6.0579 8.8814 3.2747 3.6916
U-87MG ATCC GDSC1 6.1421 8.7679 3.3699 2.9422
Hs 683 GDSC1 6.1456 7.3336 3.9379 0.2279
ONS-76 GDSC1 6.2036 7.8363 3.7779 0.7102
D283 Med GDSC1 6.2869 7.6876 3.8656 0.3572
Onda 10 GDSC1 6.4605 13.8587 1.1968 15.8717
U-118MG GDSC1 6.5724 8.1787 3.7985 0.4113
D-392MG GDSC1 6.5772 8.5547 3.6621 0.8823
H4 GDSC1 6.6914 8.5849 3.6975 0.6677
SW1088 GDSC1 7.1604 9.8679 3.4077 1.4645
LN-229 GDSC1 7.7883 14.7045 1.6561 10.2763
⏷ Show the Full List of 54 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ETK-1 GDSC1 5.2781 9.0886 2.6808 9.7401
TGBC24TKB GDSC1 5.4724 7.6724 3.4806 3.4444
TGBC1TKB GDSC1 5.9817 7.8328 3.6812 1.3744
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RL95-2 GDSC1 4.611 7.9236 2.756 11.2653
KLE GDSC1 5.2369 8.718 2.8319 8.7514
EN GDSC1 5.8104 11.9732 1.6546 15.0487
ESS-1 GDSC1 6.4493 10.2204 2.9003 5.3963
MFE-319 GDSC1 6.4612 7.7525 3.9069 0.1903
AN3-CA GDSC1 6.5373 10.9498 2.6217 7.0384
MFE-296 GDSC1 6.5804 8.4639 3.6975 0.7423
MFE-280 GDSC1 6.7809 9.0659 3.5534 1.1672
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KTCTL-140 GDSC1 2.5395 9.4619 0.1487 34.8677
RXF 393L GDSC1 3.1483 8.2657 1.3031 26.9162
KTCTL-1M GDSC1 4.1416 8.2602 2.2005 17.0366
786-O GDSC1 4.3485 5.734 3.6379 5.299
UO-31 GDSC1 4.4622 10.6505 1.2737 21.6333
A-704 GDSC1 4.5345 9.0829 2.1162 16.1564
NCC021 GDSC1 4.6949 7.1748 3.1931 7.6314
KTCTL-21 GDSC1 4.7212 7.1246 3.2379 7.2018
KTCTL-26A GDSC1 4.7531 6.4384 3.5979 4.3249
VMRC-RCZ GDSC1 4.7559 11.5062 1.0847 21.6111
OS-RC-2 GDSC1 4.7657 7.1346 3.2661 6.8457
769-P GDSC1 4.9155 13.6277 0.154 25.4112
KMRC-1 GDSC1 4.9482 6.9527 3.4848 4.6484
KTCTL-195 GDSC1 4.9576 9.8787 2.0539 15.1272
BFTC-909 GDSC1 5.1608 7.078 3.5645 3.5308
TK-10 GDSC1 5.1626 7.7491 3.2482 5.856
BB65-RCC GDSC1 5.2535 7.5906 3.3834 4.6267
VMRC-RCW GDSC1 5.3518 7.1819 3.6316 2.6547
LB1047-RCC GDSC1 5.4223 7.9883 3.3045 4.7987
A-498 GDSC1 5.4364 6.7653 3.8566 1.1118
HA7-RCC GDSC1 5.4401 8.0748 3.2754 4.9664
RCC10RGB GDSC1 5.5883 12.1305 1.4162 17.0975
CAL-54 GDSC1 5.6538 8.153 3.3696 3.8358
LB2241-RCC GDSC1 6.0521 8.3141 3.5167 2.1971
Caki-1 GDSC1 6.2066 11.5889 2.1136 11.1199
LB996-RCC GDSC1 6.3386 8.8369 3.4412 2.226
KTCTL-13 GDSC1 6.3494 8.3517 3.6423 1.1689
KMRC-20 GDSC1 6.3886 10.0577 2.9383 5.2662
SW13 GDSC1 6.5736 8.1349 3.8146 0.3658
SN12C GDSC1 6.5743 8.6222 3.6352 0.9956
SW156 GDSC1 7.2858 15.8517 0.8007 15.8503
ACHN GDSC1 7.8778 14.2079 1.9336 8.5531
⏷ Show the Full List of 32 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 44 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-175 GDSC1 3.2939 5.9993 2.5246 18.3444
LS411N GDSC1 3.4699 8.6941 1.3907 24.9647
HCT 116 GDSC1 3.9767 7.4261 2.4735 15.7291
LS1034 GDSC1 4.1863 5.4517 3.6404 5.8871
SW48 GDSC1 4.2463 5.8441 3.497 6.7852
COLO205 GDSC1 4.3501 5.4729 3.7698 4.2535
T84 GDSC1 4.474 6.0255 3.5934 5.218
SNU-C2B GDSC1 4.4925 8.3276 2.4594 13.882
CCK-81 GDSC1 4.5012 6.6135 3.3219 7.2584
SW948 GDSC1 4.6745 7.6649 2.9344 9.6944
SW620 GDSC1 4.7432 6.5248 3.5488 4.73
RKO GDSC1 4.8027 6.3438 3.6782 3.5775
NCI-H747 GDSC1 4.8261 8.8233 2.4764 12.6176
LS513 GDSC1 4.9046 7.2971 3.2875 6.2691
SNU-1040 GDSC1 4.9585 8.7076 2.6343 11.04
HT-29 GDSC1 5.0249 6.812 3.6027 3.5746
KM12 GDSC1 5.1435 7.281 3.4583 4.3461
SNU-C1 GDSC1 5.218 7.1475 3.5677 3.3782
RCM-1 [Human ESC] GDSC1 5.2202 7.4404 3.4327 4.3475
HCT 15 GDSC1 5.28 9.7394 2.3642 11.9918
SNU-C5 GDSC1 5.3419 8.1399 3.1814 5.889
SNU-407 GDSC1 5.3497 12.1622 1.2219 18.9178
GP5d GDSC1 5.473 7.2062 3.6884 2.0605
COLO 320HSR GDSC1 5.5256 7.815 3.4473 3.5646
SNU-61 GDSC1 5.5865 7.2416 3.7326 1.611
MDST8 GDSC1 5.7907 7.3852 3.7725 1.1257
SW626 GDSC1 5.9163 7.9072 3.6191 1.7984
CW-2 GDSC1 5.9171 11.9301 1.7513 14.1624
HCC2998 GDSC1 5.919 8.8623 3.2041 4.4259
HT-55 GDSC1 6.1358 7.4365 3.898 0.3377
SNU-81 GDSC1 6.2547 11.4348 2.2185 10.3236
HT115 GDSC1 6.314 7.7768 3.844 0.4073
SW1116 GDSC1 6.3994 8.0437 3.7803 0.5651
NCI-H716 GDSC1 6.6036 11.3273 2.4888 7.7605
CL-11 GDSC1 6.6468 9.046 3.502 1.5328
CaR-1 GDSC1 6.6587 8.4137 3.7472 0.5216
SW1463 GDSC1 6.696 8.4213 3.7588 0.4661
SW1417 GDSC1 6.7057 8.4648 3.7469 0.497
C2BBe1 GDSC1 6.7555 8.9345 3.5928 1.022
SW837 GDSC1 6.8471 8.6879 3.7209 0.5019
LS123 GDSC1 6.9765 8.8396 3.7159 0.4532
LS180 GDSC1 6.9796 8.7691 3.742 0.3823
COLO 678 GDSC1 7.0284 8.8394 3.7353 0.3792
LoVo GDSC1 7.6117 9.3493 3.7676 0.1531
⏷ Show the Full List of 44 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1 6.828 8.3271 3.8404 0.2139
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHH-4 GDSC1 2.7552 5.1398 2.3355 22.4227
SNU-423 GDSC1 3.1267 6.8071 1.9827 22.9309
SNU-387 GDSC1 3.4124 4.752 3.1859 12.9153
HLE GDSC1 4.3206 7.0875 2.938 10.8919
SNU-398 GDSC1 4.3412 11.2986 0.8496 24.2889
SNU-449 GDSC1 4.8932 7.9022 2.9827 8.632
JHH-6 GDSC1 5.3252 9.8004 2.3672 11.8365
SNU-475 GDSC1 5.4364 9.9282 2.3846 11.3906
Hep 3B2.1-7 GDSC1 5.5884 7.5604 3.5966 2.4478
JHH-7 GDSC1 5.6876 7.5252 3.6643 1.8655
JHH-2 GDSC1 5.7532 8.1082 3.4466 3.1268
JHH-1 GDSC1 5.9296 7.4206 3.8205 0.7586
Hep-G2/C3A GDSC1 5.9638 7.3264 3.8705 0.5305
SK-HEP-1 GDSC1 6.1111 9.2737 3.1302 4.5411
HuH-1 GDSC1 6.1686 7.4903 3.8912 0.3412
Huh-7 GDSC1 6.6536 8.7871 3.6058 1.0525
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 170 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H847 GDSC1 2.382 5.8007 1.6754 28.771
NCI-H2227 GDSC1 3.0658 5.1497 2.6613 18.4873
IST-SL1 GDSC1 3.4339 6.035 2.6466 16.7885
NCI-H2110 GDSC1 3.5298 7.2637 2.1481 19.9428
NCI-H64 GDSC1 3.8023 4.1837 3.7858 6.601
NCI-H1975 GDSC1 3.8293 8.7103 1.7048 21.5667
SBC-3 GDSC1 3.8705 5.2444 3.446 8.7375
HCC44 GDSC1 3.9718 5.9677 3.1917 10.2661
EPLC-272H GDSC1 3.9909 6.8163 2.7892 13.3019
LK-2 GDSC1 3.9986 6.0983 3.1517 10.4666
UMC-11 GDSC1 4.1418 7.9176 2.3718 15.8192
NCI-H211 GDSC1 4.1988 7.3921 2.683 13.2983
NCI-H292 GDSC1 4.2904 5.6187 3.6471 5.4375
A-427 GDSC1 4.3008 6.0667 3.4319 7.0957
NCI-H810 GDSC1 4.3094 5.6883 3.6283 5.5162
NCI-H647 GDSC1 4.3427 8.466 2.2672 15.8055
Lu-135 GDSC1 4.3491 6.9501 3.0304 10.0706
NCI-H520 GDSC1 4.3564 5.9919 3.5155 6.2364
NCI-H226 GDSC1 4.3723 7.3229 2.8632 11.2818
EMC-BAC-1 GDSC1 4.3858 7.5895 2.7411 12.1663
HOP-62 GDSC1 4.4337 8.1046 2.5229 13.6265
LC-2/ad GDSC1 4.465 10.6017 1.3004 21.4748
DMS 273 GDSC1 4.4935 6.197 3.5233 5.7039
NCI-H2135 GDSC1 4.549 8.2743 2.5316 13.1534
NCI-H1869 GDSC1 4.5681 6.0846 3.6364 4.5777
NCI-H358 GDSC1 4.5983 7.8897 2.7629 11.2563
LCLC-97TM1 GDSC1 4.6183 6.144 3.6446 4.3599
NCI-H1944 GDSC1 4.6479 9.1628 2.1675 15.4042
NCI-H1155 GDSC1 4.6497 6.5404 3.4726 5.6006
NCI-H3122 GDSC1 4.6766 7.5694 2.9835 9.3106
CAL-12T GDSC1 4.6866 7.5727 2.9896 9.231
BEN GDSC1 4.7392 9.0067 2.3176 14.0436
NCI-H196 GDSC1 4.7778 5.9822 3.834 2.4763
SW1271 GDSC1 4.8042 19.223 -2.7306 33.9985
NCI-H1048 GDSC1 4.8055 6.5574 3.5771 4.3368
NCI-H2591 GDSC1 4.8137 9.2569 2.2513 14.2577
NCI-H1436 GDSC1 4.823 8.0501 2.8572 9.8034
COR-L105 GDSC1 4.8326 13.4778 0.1623 25.6496
NCI-H1092 GDSC1 4.8346 7.5505 3.1124 7.82
Lu-65 GDSC1 4.8444 9.2964 2.2555 14.1258
NCI-H510A GDSC1 4.9071 7.4756 3.2022 6.9141
NCI-H748 GDSC1 4.912 6.7449 3.5599 4.1784
SBC-5 GDSC1 4.9205 7.0776 3.4055 5.3245
PC-14 GDSC1 4.9738 7.9949 2.9963 8.286
NCI-H2373 GDSC1 4.9807 8.4825 2.7619 10.0268
LXF 289 GDSC1 4.99 6.9144 3.5313 4.1901
NCI-H1299 GDSC1 4.9921 6.643 3.6611 3.2256
HARA [Human squamous cell lung carcinoma] GDSC1 5.0724 10.8921 1.6394 17.3945
NCI-H2795 GDSC1 5.0803 7.6952 3.2179 6.3043
COR-L311 GDSC1 5.0822 6.742 3.6715 2.9415
Calu-6 GDSC1 5.1153 8.1022 3.0452 7.5065
EMC-BAC-2 GDSC1 5.1169 9.1966 2.5112 11.4445
NCI-H1915 GDSC1 5.1377 11.6027 1.337 18.9536
NCI-H2029 GDSC1 5.1518 6.8603 3.6595 2.8734
NCI-H187 GDSC1 5.1701 6.8751 3.6638 2.8039
NCI-H1781 GDSC1 5.1817 7.8771 3.1998 6.1669
NCI-H82 GDSC1 5.2093 10.5182 1.9287 15.1411
COR-L23 GDSC1 5.257 10.3821 2.0314 14.3219
NCI-H1876 GDSC1 5.2661 7.2481 3.5508 3.3922
NCI-H2122 GDSC1 5.2796 7.0768 3.6371 2.7613
NCI-H460 GDSC1 5.2966 7.189 3.5962 3.0091
NCI-H1563 GDSC1 5.2973 7.0896 3.6416 2.6944
COR-L321 GDSC1 5.3113 7.2995 3.5546 3.2682
NCI-H2030 GDSC1 5.3596 8.9022 2.8283 8.4362
HCC78 GDSC1 5.3912 7.2242 3.6352 2.5544
NCI-H3255 GDSC1 5.4035 8.2032 3.1917 5.6607
Lu-139 GDSC1 5.4333 11.4048 1.6586 16.1384
NCI-H1792 GDSC1 5.4403 8.2357 3.2001 5.5103
NCI-H345 GDSC1 5.4459 6.219 4.0709 0.1767
LOU-NH91 GDSC1 5.4542 8.5791 3.0469 6.5896
NCI-H838 GDSC1 5.4626 8.3351 3.1677 5.6911
NCI-H1437 GDSC1 5.4651 7.8295 3.4045 3.9908
Lu-99A GDSC1 5.4677 9.0403 2.8358 8.0896
LCLC-103H GDSC1 5.482 9.3826 2.681 9.1679
NCI-H23 GDSC1 5.5627 8.2719 3.2602 4.7939
NCI-H446 GDSC1 5.5708 11.8971 1.5181 16.5601
NCI-H1304 GDSC1 5.5746 7.6559 3.5469 2.7966
NCI-H1770 GDSC1 5.5781 7.782 3.4927 3.1509
NCI-H2085 GDSC1 5.5891 11.2238 1.8616 14.4155
NCI-H720 GDSC1 5.5942 7.482 3.6339 2.2007
NCI-H526 GDSC1 5.6058 8.4343 3.2117 5.0409
COLO 668 GDSC1 5.6101 11.201 1.8879 14.1878
NCI-H1581 GDSC1 5.6313 8.0069 3.4224 3.5216
NCI-H1694 GDSC1 5.6609 8.6908 3.127 5.516
NCI-H2803 GDSC1 5.666 10.5148 2.2615 11.5825
Lu-134-A GDSC1 5.6765 14.6063 0.2604 22.6031
NCI-H1688 GDSC1 5.695 9.0701 2.9714 6.5415
NCI-H727 GDSC1 5.7039 8.7358 3.1328 5.377
IA-LM GDSC1 5.7048 7.7876 3.5606 2.4766
NCI-H522 GDSC1 5.7056 12.1429 1.4961 16.2889
HCC15 GDSC1 5.7291 8.6633 3.1817 4.9777
NCI-H1838 GDSC1 5.7373 9.1692 2.9519 6.5788
RERF-LC-KJ GDSC1 5.7559 11.8957 1.6534 15.212
COR-L88 GDSC1 5.7751 8.0629 3.4787 2.8784
NCI-H2228 GDSC1 5.7813 8.6434 3.2222 4.585
NCI-H1573 GDSC1 5.784 7.9792 3.52 2.5992
SK-LU-1 GDSC1 5.8031 9.0354 3.0555 5.6971
NCI-H1734 GDSC1 5.8207 10.2897 2.4757 9.7064
NCI-H650 GDSC1 5.8843 13.0968 1.1586 17.6576
NCI-H2595 GDSC1 5.9028 9.0834 3.0941 5.2109
NCI-H596 GDSC1 5.9308 11.4695 1.9839 12.6742
NCI-H2009 GDSC1 5.942 7.8065 3.6731 1.4657
NCI-H1993 GDSC1 5.9689 11.3308 2.0769 11.975
PaCa-3 GDSC1 5.9707 8.7453 3.2862 3.7776
NCI-H2172 GDSC1 5.9916 9.9207 2.7616 7.31
NCI-H209 GDSC1 6.0082 16.3605 -0.3563 24.1285
NCI-H1703 GDSC1 6.0198 8.0181 3.6238 1.6338
NCI-H2444 GDSC1 6.0247 7.1786 3.9478 0.2516
NCI-H2196 GDSC1 6.0307 7.6505 3.7755 0.8655
NCI-H2869 GDSC1 6.0312 15.2601 0.2038 21.8275
HCC33 GDSC1 6.0553 13.9415 0.8691 18.6748
EBC-1 GDSC1 6.0859 9.8751 2.8414 6.5469
NCI-H2405 GDSC1 6.0869 10.2627 2.6621 7.77
NCI-H1963 GDSC1 6.0946 7.979 3.6748 1.2776
NCI-H1568 GDSC1 6.1044 8.1522 3.6095 1.6048
NCI-H2461 GDSC1 6.1264 9.2436 3.1525 4.3639
NCI-H2369 GDSC1 6.1381 11.0242 2.3366 9.838
NCI-H1623 GDSC1 6.1397 8.2556 3.5842 1.6968
NCI-H2170 GDSC1 6.1455 8.5986 3.444 2.4873
NCI-H2291 GDSC1 6.1688 10.5307 2.5886 8.0771
NCI-H2141 GDSC1 6.2141 7.797 3.797 0.6289
NCI-H1651 GDSC1 6.2159 8.3454 3.5838 1.6046
NCI-H1435 GDSC1 6.247 8.2014 3.6557 1.2086
NCI-H524 GDSC1 6.2522 7.9703 3.7475 0.7947
DMS 114 GDSC1 6.2634 7.8744 3.7882 0.6268
NCI-H2804 GDSC1 6.2709 10.7409 2.5548 8.0674
NCI-H1793 GDSC1 6.2718 8.3169 3.6212 1.3503
NCI-H2171 GDSC1 6.2814 8.0921 3.7133 0.9138
DMS 79 GDSC1 6.2972 14.1878 0.9226 17.7381
NCI-H2722 GDSC1 6.3056 14.6143 0.7206 18.7159
COR-L95 GDSC1 6.3242 13.0403 1.4976 14.561
NCI-H2081 GDSC1 6.3262 8.2327 3.6785 1.0265
NCI-H1650 GDSC1 6.3338 9.938 2.9605 5.228
Calu-3 GDSC1 6.3414 8.2801 3.6667 1.065
NCI-H1755 GDSC1 6.3512 8.1223 3.7313 0.7815
ChaGo-K-1 GDSC1 6.3561 10.3237 2.799 6.2509
RERF-LC-Sq1 GDSC1 6.3637 10.1001 2.9048 5.5351
NCI-H1693 GDSC1 6.4175 8.0921 3.7697 0.5905
NCI-H322M GDSC1 6.4314 9.7826 3.0845 4.2413
NCI-H2023 GDSC1 6.4582 8.3188 3.7017 0.8168
SBC-1 GDSC1 6.4599 8.1459 3.7668 0.5738
SK-MES-1 GDSC1 6.461 9.0635 3.4074 2.2494
NCI-H2731 GDSC1 6.4781 8.8312 3.5104 1.677
NCI-H1836 GDSC1 6.5 8.2839 3.7319 0.6712
NCI-H69 GDSC1 6.5331 8.4583 3.6802 0.8445
ABC-1 GDSC1 6.5382 13.6055 1.3721 14.713
HCC827 GDSC1 6.5654 8.1956 3.7898 0.4403
NCI-H1355 GDSC1 6.597 8.5066 3.6884 0.765
NCI-H441 GDSC1 6.6052 8.7325 3.6061 1.0934
Ms-1 GDSC1 6.6211 8.3466 3.7569 0.5117
RERF-LC-MS GDSC1 6.6266 12.8846 1.7753 12.1678
COR-L303 GDSC1 6.6481 8.0325 3.8774 0.1939
Lu-165 GDSC1 6.6823 12.7857 1.8584 11.536
NCI-H1666 GDSC1 6.7879 8.3685 3.8117 0.2871
A-549 GDSC1 6.8192 8.928 3.6218 0.8576
DMS 53 GDSC1 6.9227 8.4842 3.8203 0.2257
NCI-H661 GDSC1 6.9357 8.9853 3.6475 0.6868
HOP-92 GDSC1 6.9681 9.6044 3.4259 1.5658
LC-1/sq GDSC1 7.0473 9.2521 3.5937 0.8031
SW1573 GDSC1 7.1097 8.8863 3.7487 0.3165
NCI-H2818 GDSC1 7.1343 17.5751 -0.1324 20.3482
NCI-H1648 GDSC1 7.1465 9.1324 3.6758 0.4857
NCI-H841 GDSC1 7.1512 13.9704 1.6024 11.9389
NCI-H2087 GDSC1 7.1675 9.1846 3.6652 0.5057
SHP-77 GDSC1 7.1948 15.2628 1.0206 14.9689
NCI-H513 GDSC1 7.3225 9.4878 3.6157 0.5728
NCI-H2347 GDSC1 7.3987 9.4419 3.6605 0.4173
EKVX GDSC1 7.458 14.0811 1.7422 10.4747
CPC-N GDSC1 7.6667 16.9178 0.5459 16.1806
NCI-H2342 GDSC1 7.7371 9.3367 3.814 0.0831
⏷ Show the Full List of 170 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1 6.6173 8.897 3.5475 1.3462
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYSE-180 GDSC1 4.1308 11.5922 0.5263 26.5764
KYSE-450 GDSC1 4.4212 7.0725 3.0285 9.8291
T.T GDSC1 4.4584 7.3453 2.9224 10.5198
KYSE-270 GDSC1 4.587 6.8937 3.2497 7.539
KYSE-150 GDSC1 5.1213 7.4841 3.3472 5.2253
TE-8 GDSC1 5.2469 9.1741 2.6168 10.2942
EC-GI-10 GDSC1 5.3867 9.0054 2.7972 8.5887
OE33 GDSC1 5.4003 7.1872 3.6569 2.3936
TE-10 GDSC1 5.4564 8.2364 3.2101 5.3994
KYSE-510 GDSC1 5.6457 9.5711 2.7017 8.5841
TE-5 GDSC1 5.7605 8.4122 3.3148 3.9938
TE-9 GDSC1 5.7712 7.4525 3.7361 1.3404
TE-1 GDSC1 5.7753 8.0297 3.4933 2.7841
TE-15 GDSC1 5.9027 8.192 3.4913 2.5813
KYSE-140 GDSC1 5.9326 10.6486 2.3792 10.0731
OE19 GDSC1 5.9417 7.3167 3.8651 0.5667
OE21 GDSC1 6.033 8.9521 3.2294 4.0342
TE-4 GDSC1 6.0772 8.0713 3.6295 1.5314
KYSE-70 GDSC1 6.1589 9.3811 3.1096 4.5848
COLO 680N GDSC1 6.3209 8.5776 3.5392 1.7127
TE-11 GDSC1 6.6814 8.6239 3.679 0.7408
TE-6 GDSC1 6.8102 8.7539 3.6826 0.6447
KYSE-520 GDSC1 7.2508 9.4105 3.616 0.6086
KYSE-410 GDSC1 8.831 17.6835 0.9199 12.0227
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A2780 GDSC1 0.0129 11.3846 -3.2262 51.4223
IGROV-1 GDSC1 3.8247 5.8509 3.1118 11.5081
OVCAR-8 GDSC1 3.8945 6.7932 2.7142 14.2644
TOV-112D GDSC1 4.2098 6.0306 3.3725 7.9034
SK-OV-3 GDSC1 4.2124 7.3422 2.7196 12.9697
OC 314 GDSC1 4.3801 5.6117 3.7248 4.5028
EFO-27 GDSC1 4.4203 8.3163 2.4061 14.5276
OV56 GDSC1 4.6142 6.2225 3.6028 4.6969
OVTOKO GDSC1 4.631 6.4778 3.4895 5.5267
ES-2 GDSC1 4.6383 7.837 2.8206 10.6833
OVCAR-5 GDSC1 4.6772 9.6411 1.9523 16.7499
FU-OV-1 GDSC1 4.9576 6.7207 3.602 3.7463
Caov-3 GDSC1 5.0292 6.8616 3.5821 3.715
Kuramochi GDSC1 5.1614 7.3943 3.4164 4.6101
OVKATE GDSC1 5.2435 7.0497 3.628 2.8987
TYK-nu GDSC1 5.2826 6.9653 3.689 2.4018
OAW42 GDSC1 5.2976 6.7628 3.7867 1.7359
OV-90 GDSC1 5.3184 8.0619 3.2029 5.7901
JHOS-2 GDSC1 5.3923 7.3881 3.5623 3.0464
OVISE GDSC1 5.6963 9.8285 2.6126 9.0805
DOV13 GDSC1 5.9368 7.4524 3.8114 0.792
OVK18 GDSC1 6.1716 7.8417 3.7624 0.7991
TOV-21G GDSC1 6.1872 8.4088 3.5442 1.8539
Caov-4 GDSC1 6.2241 8.0061 3.7218 0.9274
EFO-21 GDSC1 6.4281 8.0121 3.803 0.4728
OVCAR-3 GDSC1 6.6233 8.4495 3.7202 0.6319
RMG-I GDSC1 6.8827 8.9547 3.6376 0.755
OAW28 GDSC1 6.9355 8.9458 3.6618 0.639
OVCAR-4 GDSC1 7.0694 9.5527 3.4899 1.1897
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SUIT-2 GDSC1 3.3504 10.7971 0.2429 30.8541
MZ-PC-1 GDSC1 4.2091 6.6604 3.0573 10.3778
KP-4 GDSC1 4.445 8.2366 2.4661 14.0026
PSN1 GDSC1 4.6487 13.6492 -0.0723 27.188
Panc 03.27 GDSC1 4.6728 6.1932 3.6602 4.0773
Panc 08.13 GDSC1 4.6813 6.8776 3.3298 6.6126
QGP-1 GDSC1 4.8079 7.1656 3.2819 6.5961
Panc 10.05 GDSC1 4.8483 6.4713 3.648 3.6838
HuP-T3 GDSC1 5.0666 6.7909 3.6391 3.2099
PaTu 8988t GDSC1 5.0824 6.839 3.6266 3.2639
HuP-T4 GDSC1 5.1355 10.4338 1.9147 15.4652
SU.86.86 GDSC1 5.1404 7.1495 3.5182 3.9146
HPAC GDSC1 5.1804 6.8343 3.6886 2.6094
BxPC-3 GDSC1 5.2144 8.2545 3.0406 7.2663
Panc 02.03 GDSC1 5.2854 6.9225 3.7097 2.2583
KP-3 GDSC1 5.399 9.6132 2.5113 10.609
PaTu 8902 GDSC1 5.6323 10.3536 2.3161 11.3067
YAPC GDSC1 5.6759 8.2347 3.3456 3.9555
DAN-G GDSC1 5.6884 8.4267 3.2656 4.4814
Capan-1 GDSC1 5.9086 7.5683 3.7535 1.0901
AsPC-1 GDSC1 5.9461 8.0766 3.563 2.0802
Capan-2 GDSC1 6.3316 8.0458 3.752 0.7151
MIA PaCa-2 GDSC1 6.499 7.7458 3.9225 0.1513
PL4 GDSC1 6.7285 8.4815 3.7496 0.4768
Hs 766T GDSC1 6.7452 8.9142 3.5962 1.0162
Panc 04.03 GDSC1 6.7754 8.5086 3.7578 0.43
KP-2 GDSC1 6.847 8.2721 3.8658 0.1636
CFPAC-1 GDSC1 6.8521 8.4494 3.8069 0.2756
SW1990 GDSC1 6.8691 8.8288 3.6784 0.6232
HPAF-II GDSC1 7.1089 8.7281 3.8028 0.2075
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H28 GDSC1 5.5884 9.3401 2.7736 8.2206
IST-Mes1 GDSC1 5.7676 7.8507 3.5669 2.3331
NCI-H2052 GDSC1 6.4141 10.6992 2.6622 7.0348
MPP 89 GDSC1 6.4817 8.4586 3.6584 0.976
MSTO-211H GDSC1 7.0324 8.7918 3.7534 0.3335
NCI-H2452 GDSC1 7.0739 8.9028 3.7299 0.3746
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LNCaP clone FGC GDSC1 3.1689 10.4909 0.2308 31.6772
PC-3 GDSC1 6.051 9.6134 2.9406 5.9453
22Rv1 GDSC1 6.2091 10.0294 2.8454 6.251
DU145 GDSC1 6.4363 11.1141 2.4845 8.1565
VCaP GDSC1 6.5794 8.0385 3.8506 0.2727
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1 6.3125 8.117 3.7171 0.8711
Cancer Drug Sensitivity Data Curated from 56 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-7951 GDSC1 3.591 7.8757 1.9043 21.3109
WM1552C GDSC1 3.7006 6.6463 2.6086 15.8768
A-431 GDSC1 4.534 6.7714 3.2691 7.5621
WM35 GDSC1 4.6843 7.0483 3.2477 7.2414
IST-MEL1 GDSC1 4.7778 9.1808 2.2612 14.3095
SK-MEL-24 GDSC1 4.8099 6.2782 3.7145 3.2847
SK-MEL-30 GDSC1 4.971 6.5765 3.6788 3.1471
IPC-298 GDSC1 4.9922 6.4081 3.7704 2.4376
M14 GDSC1 5.0641 8.9025 2.6169 10.8408
IGR-1 GDSC1 5.1309 6.7779 3.6847 2.7411
LB2518-MEL GDSC1 5.155 7.847 3.1961 6.2656
SK-MEL-28 GDSC1 5.2312 7.328 3.4922 3.8899
RVH-421 GDSC1 5.2515 8.9033 2.7521 9.2961
SH-4 GDSC1 5.3169 9.8106 2.3562 11.9377
A-375 GDSC1 5.3239 7.7759 3.3415 4.7632
WM115 GDSC1 5.3444 6.8592 3.77 1.7625
HT-144 GDSC1 5.348 7.3695 3.5446 3.2604
UACC-257 GDSC1 5.3582 7.6589 3.4176 4.1343
COLO 679 GDSC1 5.3584 7.1451 3.6519 2.5057
CHL-1 GDSC1 5.4049 8.9857 2.8192 8.3787
Mel Ho GDSC1 5.4084 7.8285 3.3702 4.3596
WM278 GDSC1 5.4626 9.5626 2.5806 9.9382
A2058 GDSC1 5.483 6.6992 3.9053 0.8012
Mel JuSo GDSC1 5.5156 10.6447 2.0917 13.1456
G-mel GDSC1 5.5331 8.306 3.2261 5.104
COLO 800 GDSC1 5.5574 8.1731 3.3026 4.5059
CP66-MEL GDSC1 5.5719 7.4116 3.6524 2.1218
SK-MEL-2 GDSC1 5.6028 6.5408 4.0155 0.2591
Hs 938.T GDSC1 5.7191 9.4442 2.8106 7.6242
G-361 GDSC1 5.8326 7.3549 3.8036 0.9271
LB373-MEL-D GDSC1 5.8426 7.7203 3.6604 1.6653
SK-MEL-5 GDSC1 5.8442 7.0239 3.9342 0.3829
HMV-II GDSC1 5.8747 9.8879 2.7022 8.0019
IGR-37 GDSC1 5.9377 7.8529 3.652 1.5857
451Lu GDSC1 6.0024 8.1711 3.5517 2.0647
A-388 GDSC1 6.0658 8.6477 3.3813 2.9978
SK-MEL-1 GDSC1 6.0718 7.2686 3.9335 0.2687
UACC-62 GDSC1 6.0974 7.2699 3.9426 0.2352
MZ-MEL-7 GDSC1 6.131 7.9934 3.6857 1.1847
MZ-MEL-2 GDSC1 6.1692 8.7634 3.3861 2.7996
GAK GDSC1 6.1772 7.5982 3.8555 0.4464
SK-MEL-3 GDSC1 6.1833 7.5553 3.8735 0.3863
WT2-iPS GDSC1 6.1938 7.5018 3.8966 0.314
COLO 783 GDSC1 6.2016 7.5875 3.8689 0.3906
DJM-1 GDSC1 6.2686 9.9894 2.8992 5.7655
LOX-IMVI GDSC1 6.2794 8.3921 3.5946 1.4748
A101D GDSC1 6.3081 9.4053 3.1824 3.8378
CP50-MEL-B GDSC1 6.3363 8.068 3.7456 0.7364
WM793 GDSC1 6.4015 12.0056 2.0443 11.0733
MMAc-SF GDSC1 6.4414 8.0654 3.7889 0.5108
Hs 940.T GDSC1 6.5915 8.1326 3.8221 0.3382
VMRC-MELG GDSC1 6.6081 8.0814 3.8461 0.2727
MeWo GDSC1 6.6582 11.2993 2.5345 7.3493
COLO 792 GDSC1 6.6973 8.0737 3.8807 0.1747
COLO 829 GDSC1 7.461 9.3216 3.7246 0.2567
EquiPSC Line K2 GDSC1 7.1999 9.6116 3.522 0.9616
⏷ Show the Full List of 56 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1 4.6155 8.4958 2.4743 13.3421
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Hs 633.T GDSC1 3.6888 6.3616 2.7361 14.97
EW-8 GDSC1 4.3087 6.2991 3.3223 7.9296
SW982 GDSC1 4.4481 10.981 1.097 22.6398
RKN GDSC1 4.6665 7.5175 3.0015 9.2049
TE 441.T GDSC1 5.2245 7.1696 3.5615 3.4083
G-401 GDSC1 5.2627 9.8475 2.2986 12.4996
Rh41 GDSC1 5.2854 7.1352 3.614 2.9086
A-204 GDSC1 5.3394 10.1083 2.2266 12.7625
SW872 GDSC1 5.3856 7.1146 3.6807 2.2638
VA-ES-BJ GDSC1 5.5091 7.2743 3.6783 2.0638
Rh30 GDSC1 5.5861 8.5758 3.1336 5.6425
HT-1080 GDSC1 5.6775 7.8125 3.5349 2.688
RD GDSC1 5.6993 8.9756 3.0183 6.1976
SK-UT-1 GDSC1 5.7492 7.8822 3.5434 2.5099
GCT GDSC1 5.7785 8.0504 3.486 2.8251
KYM-1 GDSC1 5.8751 7.232 3.8694 0.6001
SW684 GDSC1 6.0377 7.2932 3.9118 0.3461
G-402 GDSC1 6.0734 10.5029 2.5407 8.6277
MFH-ino GDSC1 6.1097 8.965 3.2666 3.6503
MES-SA GDSC1 6.3616 7.5176 3.9518 0.1348
SK-LMS-1 GDSC1 7.4135 19.1364 -0.6938 21.8064
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RERF-GC-1B GDSC1 3.7844 6.5023 2.7567 14.4025
RF-48 GDSC1 3.8364 6.7987 2.6588 14.9237
SNU-1 GDSC1 3.9411 8.8115 1.7523 20.8114
NUGC-4 GDSC1 4.1648 8.6812 2.01 18.2505
23132/87 GDSC1 4.5206 7.0049 3.1422 8.5991
IM95 GDSC1 4.8688 8.2387 2.7986 10.1006
MKN1 GDSC1 5.0036 8.6713 2.6859 10.5198
ECC10 GDSC1 5.0042 7.7503 3.1377 7.1242
HGC-27 GDSC1 5.0937 7.0645 3.5281 3.9545
MKN28 GDSC1 5.135 8.4776 2.8765 8.7124
OCUM-1 GDSC1 5.4814 7.8228 3.4174 3.8646
Fu97 GDSC1 5.6673 7.4948 3.6667 1.8814
MKN45 GDSC1 5.6709 6.8508 3.9284 0.5234
TMK-1 GDSC1 5.6862 7.8989 3.5017 2.8883
AGS GDSC1 5.8189 7.4225 3.7706 1.1034
SCH GDSC1 5.9882 7.4133 3.848 0.5984
HSC-39 GDSC1 6.005 7.6066 3.7814 0.863
NUGC-3 GDSC1 6.1029 9.4509 3.0457 5.1229
MKN7 GDSC1 6.1757 9.3831 3.1183 4.4951
GCIY GDSC1 6.1761 7.9304 3.7303 0.9335
SNU-5 GDSC1 6.184 7.3325 3.9523 0.1828
SNU-16 GDSC1 6.3667 7.601 3.9252 0.182
TGBC11TKB GDSC1 6.4584 8.2394 3.7316 0.7012
NCI-N87 GDSC1 7.4549 9.5309 3.65 0.4211
Hs 746.T GDSC1 7.7555 15.4997 1.2695 12.424
SNG-M GDSC1 3.5337 6.9368 2.3109 18.783
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
B-CPAP GDSC1 4.7089 8.5371 2.5275 12.6354
BHT-101 GDSC1 5.0471 6.7272 3.6565 3.1297
HTC-C3 GDSC1 5.2286 9.3028 2.5407 10.8958
K5 GDSC1 5.2293 8.389 2.9859 7.6321
8505C GDSC1 5.351 7.6532 3.4158 4.1636
WRO GDSC1 5.4967 8.1173 3.291 4.7243
KMH-2 GDSC1 5.5491 7.6106 3.5526 2.8061
FTC-133 GDSC1 5.6017 8.3282 3.2582 4.7213
ML-1 [Human leukemia] GDSC1 5.8953 7.8347 3.6388 1.7152
ASH-3 GDSC1 6.0456 7.56 3.8165 0.679
CAL-62 GDSC1 6.1155 7.6335 3.8178 0.621
CGTH-W-1 GDSC1 6.1363 7.7495 3.7826 0.7443
TT GDSC1 6.2809 8.2056 3.6692 1.1114
8305C GDSC1 6.4011 8.0291 3.7863 0.5435
IHH-4 GDSC1 6.5486 8.1428 3.8023 0.4119
TT2609-C02 GDSC1 6.9279 13.8196 1.5297 12.8678
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BB49-HNC GDSC1 4.2534 11.1127 0.8693 24.5187
PCI-06A GDSC1 4.8987 7.5314 3.1688 7.1948
BHY GDSC1 4.9643 6.7301 3.6019 3.73
SKN-3 GDSC1 4.9818 7.4028 3.2907 6.026
HSC-3 GDSC1 5.0299 7.7133 3.1738 6.7774
PCI-38 GDSC1 5.167 8.4203 2.9272 8.2431
JHU-011 GDSC1 5.2612 7.6112 3.3787 4.6428
CAL-27 GDSC1 5.3149 9.4589 2.5265 10.7437
PCI-04B GDSC1 5.342 7.673 3.401 4.2908
BICR 22 GDSC1 5.4065 7.3134 3.6041 2.7335
SCC-15 GDSC1 5.4107 7.5297 3.5089 3.3768
SCC-9 GDSC1 5.436 7.3755 3.5933 2.7495
BICR 31 GDSC1 5.4452 7.9562 3.3338 4.5362
SAS GDSC1 5.4548 9.6814 2.5175 10.4067
Detroit 562 GDSC1 5.4649 7.9921 3.3294 4.5231
HO-1-u-1 GDSC1 5.4674 7.9999 3.3273 4.5322
BB30-HNC GDSC1 5.5065 7.5493 3.5558 2.8653
OSC-19 GDSC1 5.5143 7.7479 3.4711 3.4241
OSC-20 GDSC1 5.5379 8.2302 3.2642 4.8214
HO-1-N-1 GDSC1 5.7093 8.2015 3.38 3.6537
HSC-4 GDSC1 5.7357 8.9178 3.0682 5.7603
FaDu GDSC1 5.7874 8.8185 3.1458 5.1013
SCC-4 GDSC1 5.868 8.0782 3.522 2.4481
SCC-25 GDSC1 5.8697 8.0017 3.5556 2.2399
JHU-022 GDSC1 5.9351 9.1111 3.1008 5.0963
PCI-30 GDSC1 5.9849 8.7501 3.292 3.7125
KON GDSC1 6.083 8.1896 3.5839 1.7714
PE/CA-PJ15 GDSC1 6.0931 8.6744 3.3842 2.934
CAL-33 GDSC1 6.1053 8.3239 3.5392 1.9913
LB771-HNC GDSC1 6.1163 8.9907 3.2589 3.688
Ca9-22 GDSC1 6.1418 8.8755 3.3232 3.2341
KOSC-2 GDSC1 6.231 9.0489 3.2959 3.2553
BICR 78 GDSC1 6.283 8.1205 3.7031 0.9568
BICR 10 GDSC1 6.4926 8.4593 3.6627 0.9485
HSC-2 GDSC1 6.6186 7.881 3.9184 0.1307
SAT [Human HNSCC] GDSC1 6.6266 10.2735 2.9764 4.5784
PCI-15A GDSC1 6.701 8.5718 3.7061 0.6318
NCI-H3118 GDSC1 6.9071 9.2268 3.5455 1.0932
DOK GDSC1 7.3678 9.5437 3.6129 0.5584
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW1710 GDSC1 -0.3249 1.9412 -0.3475 57.7376
RT-112 GDSC1 3.8216 6.607 2.7396 14.3749
639V GDSC1 5.1095 7.3192 3.4179 4.7295
BFTC-905 GDSC1 5.1734 6.8834 3.662 2.8096
T24 GDSC1 5.1919 9.4387 2.4474 11.6713
CAL-29 GDSC1 5.3113 7.011 3.685 2.374
KU-19-19 GDSC1 5.4678 10.1474 2.3001 11.8825
RT-4 GDSC1 5.7873 9.4357 2.8588 7.1173
TCCSUP GDSC1 5.8844 8.8422 3.193 4.5719
5637 GDSC1 5.9887 11.3143 2.0984 11.7832
SW780 GDSC1 6.0116 7.9634 3.6422 1.5447
J82 GDSC1 6.159 9.2798 3.1548 4.287
UM-UC-3 GDSC1 6.2613 11.4459 2.2175 10.3134
647V GDSC1 6.285 7.3893 3.9685 0.1252
HT-1197 GDSC1 6.3442 7.6196 3.9108 0.2193
HT-1376 GDSC1 6.9813 8.7843 3.7372 0.3937
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LB831-BLC GDSC1 3.8599 8.3015 1.9351 19.9671
PA-1 GDSC1 4.0188 4.9131 3.747 5.7662
HEY GDSC1 4.0261 7.9149 2.2733 16.9782
ACC-OV7 GDSC1 4.0846 12.4457 0.0606 28.6618
SKN GDSC1 4.1428 6.4858 3.0873 10.3973
NEC8 GDSC1 4.1823 6.0493 3.3393 8.2693
SW954 GDSC1 4.2265 8.3546 2.2255 16.5354
KGN GDSC1 4.2965 5.6076 3.6578 5.3309
CAL-39 GDSC1 4.3119 5.9937 3.4777 6.694
Ca Ski GDSC1 4.384 8.1611 2.4538 14.313
C-33 A GDSC1 4.482 9.806 1.7121 18.9842
NT2-D1 GDSC1 4.8981 8.8208 2.5328 11.9742
C-4-I GDSC1 5.0676 8.0073 3.0576 7.549
OVCA420 GDSC1 5.1436 6.9547 3.611 3.2359
SW962 GDSC1 5.2094 9.4637 2.4479 11.6152
HeLa GDSC1 5.3215 8.1522 3.1621 6.0825
OVMIU GDSC1 5.4117 7.8527 3.3609 4.4184
JAR GDSC1 5.4324 6.994 3.7585 1.6905
SW756 GDSC1 5.5189 8.1796 3.2759 4.7814
DoTc2 4510 GDSC1 5.7355 8.5314 3.246 4.5173
HT-3 GDSC1 5.78 8.4376 3.3147 3.9557
OVCA433 GDSC1 5.8576 12.5242 1.4195 16.2896
ME-180 GDSC1 5.9408 8.2116 3.5029 2.4485
OMC-1 [Human cervical carcinoma] GDSC1 6.0893 8.0437 3.6464 1.4286
OV17R GDSC1 6.1148 10.088 2.7608 7.0323
SiHa GDSC1 6.1971 7.5809 3.8695 0.3911
MS751 GDSC1 6.2303 8.6482 3.4661 2.2347
JEG-3 GDSC1 6.2487 7.8288 3.7992 0.5966
HEC-1 GDSC1 6.301 7.6964 3.8678 0.3443
SKG-IIIa GDSC1 6.326 7.8842 3.8097 0.5102
PEO1 GDSC1 6.4475 8.526 3.6175 1.1882
NCC-IT GDSC1 6.4767 8.0633 3.8034 0.4455
JHOS-3 GDSC1 6.6155 8.4825 3.7048 0.6913
SiSo GDSC1 6.6199 12.8372 1.7933 12.0768
DSH1 GDSC1 7.034 8.9701 3.6911 0.4958
BPH-1 GDSC1 7.0697 9.3555 3.5644 0.8948
UWB1.289 GDSC1 7.9341 9.8012 3.7269 0.1503
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug

References

1 ClinicalTrials.gov (NCT00846989) Efficacy, Tolerability and Safety of RKI983 (0.05% & 0.10%) vs Xalatan in Patients With POAG or Ocular Hypertension. U.S. National Institutes of Health.
2 Effects of Y-39983, a selective Rho-associated protein kinase inhibitor, on blood flow in optic nerve head in rabbits and axonal regeneration of retinal ganglion cells in rats.Curr Eye Res. 2011 Oct;36(10):964-70.