Details of the Drug

General Information of Drug (ID: DMXT36M)

• Drug Name: Mivazerol
• Synonyms: 125472-02-8; Mivazerol [INN]; UNII-W5P1SSA8KD; Mivazerolum [INN-Latin]; alpha-Imidazol-4-yl-2,3-cresotamide; 2-HYDROXY-3-(1H-IMIDAZOL-4-YLMETHYL)-BENZAMIDE; W5P1SSA8KD; 3-((1H-Imidazol-4-yl)methyl)-2-hydroxybenzamide; Benzamide,2-hydroxy-3-(1H-imidazol-5-ylmethyl)-; Mivazerolum; ucb 22073; mivazerol[inn]; ACMC-20mrix; AC1L1TX2; 2-hydroxy-3-(1H-imidazol-5-ylmethyl)benzamide; SCHEMBL593707; SCHEMBL8097939; AC1Q5D40; CHEMBL2105189; CTK4B4380; DTXSID30154782; ZINC4674535; 3-((1H-imidazol-4-yl)methyl)-2-hydroxybenzamide; Closantel 6

Indication

Disease Entry	ICD 11	Status	REF
Angina pectoris	BA40	Discontinued in Phase 3	[1]

• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight (mw); 217.22
  Logarithm of the Partition Coefficient (xlogp); 1.1
  Rotatable Bond Count (rotbonds); 3
  Hydrogen Bond Donor Count (hbonddonor); 3
  Hydrogen Bond Acceptor Count (hbondacc); 3
• Chemical Identifiers:
  Formula: C11H11N3O2
  IUPAC Name: 2-hydroxy-3-(1H-imidazol-5-ylmethyl)benzamide
  Canonical SMILES: C1=CC(=C(C(=C1)C(=O)N)O)CC2=CN=CN2
  InChI: InChI=1S/C11H11N3O2/c12-11(16)9-3-1-2-7(10(9)15)4-8-5-13-6-14-8/h1-3,5-6,15H,4H2,(H2,12,16)(H,13,14)
  InChIKey: RLHGFJMGWQXPBW-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 60784
  CAS Number: 125472-02-8
  TTD ID: D0V1RX

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adrenergic receptor Alpha-2 (ADRA2)	TTQ8AFT	NOUNIPROTAC	Agonist	[2]

References

• [1] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002725)
• [2] Alpha-2 and imidazoline receptor agonists. Their pharmacology and therapeutic role. Anaesthesia. 1999 Feb;54(2):146-65.