Details of the Drug

General Information of Drug (ID: DMY0M8J)

Drug Name
Sargramostim
Synonyms Leukine; Leukine (TN); Sargramostim (genetical recombination); Sargramostim (USAN/INN); Sargramostim (genetical recombination) (JAN)
Indication
Disease Entry ICD 11 Status REF
Bone marrow transplantation QB63.6 Approved [1]
Therapeutic Class
Immunomodulatory Agents
Affected Organisms
Humans and other mammals
ATC Code
L03AA09: Sargramostim
L03AA: Colony stimulating factors
L03A: IMMUNOSTIMULANTS
L03: IMMUNOSTIMULANTS
L: ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
Sequence
APARSPSPSTQPWEHVNAIQEALRLLNLSRDTAAEMNETVEVISEMFDLQEPTCLQTRLE
LYKQGLRGSLTKLKGPLTMMASHYKQHCPPTPETSCATQIITFESFKENLKDFLLVIPFD
CWEPVQE
Cross-matching ID
UNII
5TAA004E22
DrugBank ID
DB00020
TTD ID
D0XT5Y

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
GMCSFR-alpha (CSF2RA) TT6MP2Z CSF2R_HUMAN Binder [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from Sargramostim (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Cladribine DM3JDRP Major Additive immunosuppressive effects by the combination of Sargramostim and Cladribine. Mature B-cell leukaemia [2A82] [3]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7905).
2 Stem cell transplantation and hematopoietic growth factors. Curr Hematol Rep. 2002 Nov;1(2):103-9.
3 Cerner Multum, Inc. "UK Summary of Product Characteristics.".