Details of the Drug

General Information of Drug (ID: DMY2IB8)

Drug Name

FR-115427

Synonyms

FR-115427; 1-Methyl-1-phenyl-1,2,3,4-tetrahydroisoquinoline; (+)-1,2,3,4-Tetrahydro-1-methyl-1-phenylisoquinoline hydrochloride; Isoquinoline, 1,2,3,4-tetrahydro-1-methyl-1-phenyl-, hydrochloride, (+)-; FR115427; 126114-66-7; SCHEMBL6021932; AC1L2Y54; LS-172648; FR 115427; 1-methyl-1-phenyl-3,4-dihydro-2H-isoquinoline hydrochloride; (+)-1-methyl-1-phenyl-1,2,3,4-tetrahydroisoquinoline hydrochloride

Indication

Disease Entry	ICD 11	Status	REF
Cerebrovascular ischaemia	8B1Z	Terminated	[1]

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

#Ro5 Violations (Lipinski):
0

Molecular Weight

259.769

Logarithm of the Partition Coefficient

Not Available

Rotatable Bond Count

1

Hydrogen Bond Donor Count

2

Hydrogen Bond Acceptor Count

1

Chemical Identifiers

Formula: C16H18ClN
IUPAC Name: 1-methyl-1-phenyl-3,4-dihydro-2H-isoquinoline;hydrochloride
Canonical SMILES: CC1(C2=CC=CC=C2CCN1)C3=CC=CC=C3.Cl
InChI: InChI=1S/C16H17N.ClH/c1-16(14-8-3-2-4-9-14)15-10-6-5-7-13(15)11-12-17-16;/h2-10,17H,11-12H2,1H3;1H
InChIKey: LUSUZDOXGNAITA-UHFFFAOYSA-N

Cross-matching ID

PubChem CID: 130852
CAS Number: 126114-66-7
TTD ID: D02OTH

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
N-methyl-D-aspartate receptor (NMDAR)	TT9IK2Z	NOUNIPROTAC	Modulator	[2]

Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This Drug

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009401)
2	Non-competitive NMDA antagonists, FR115427 and MK801, enhance neuronal survival in primary culture. Neurosci Lett. 1995 Feb 9;185(2):107-10.