Details of the Drug

General Information of Drug (ID: DMY91A3)

Drug Name
ML323
Synonyms ML 323; ML-323
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Preclinical [1]
Drug Type
Small molecular drug
Structure
3D MOL is unavailable 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 384.5
Logarithm of the Partition Coefficient (xlogp) 4.6
Rotatable Bond Count (rotbonds) 6
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 5
Chemical Identifiers
Formula
C23H24N6
IUPAC Name
5-methyl-2-(2-propan-2-ylphenyl)-N-[[4-(triazol-1-yl)phenyl]methyl]pyrimidin-4-amine
Canonical SMILES
CC1=CN=C(N=C1NCC2=CC=C(C=C2)N3C=CN=N3)C4=CC=CC=C4C(C)C
InChI
InChI=1S/C23H24N6/c1-16(2)20-6-4-5-7-21(20)23-24-14-17(3)22(27-23)25-15-18-8-10-19(11-9-18)29-13-12-26-28-29/h4-14,16H,15H2,1-3H3,(H,24,25,27)
InChIKey
VUIRVWPJNKZOSS-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
60167849
TTD ID
D0M5FO
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Deubiquitinating enzyme 1 (USP1) TTG9MT5 UBP1_HUMAN Inhibitor [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 38 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC2 6.1431 8.5287 3.4724 1.8664
CHSA8926 GDSC2 4.3698 9.9697 1.5378 16.9905
NOS-1 [Human HNSCC] GDSC2 4.5032 7.5472 2.8578 8.7473
CADO-ES1 GDSC2 4.5834 9.6259 1.8845 14.4231
EW-12 GDSC2 4.6309 6.6375 3.4105 4.9327
EW-7 GDSC2 4.7487 6.8084 3.4139 4.6207
EW-24 GDSC2 4.7837 6.3825 3.6465 3.1057
TC-71 GDSC2 4.8661 9.6194 2.1119 12.3209
EW-18 GDSC2 4.869 6.8408 3.4842 3.909
SK-PN-DW GDSC2 4.9278 10.1321 1.905 13.3567
A-673 GDSC2 4.9999 6.7701 3.6063 2.8975
ES8 GDSC2 5.1366 9.6851 2.2853 10.5977
CAL-78 GDSC2 5.1393 8.3903 2.9222 6.7394
HOS GDSC2 5.1723 8.4393 2.9217 6.6674
H-EMC-SS GDSC2 5.2761 9.7052 2.3782 9.7053
EW-13 GDSC2 5.3032 7.8977 3.2707 4.2838
ES5 GDSC2 5.3253 9.3115 2.6059 8.2288
EW-3 GDSC2 5.4175 9.2946 2.6789 7.5829
SaOS-2 GDSC2 5.46 9.8085 2.4595 8.7933
HuO-3N1 GDSC2 5.4976 8.1726 3.2659 3.9401
CHSA0011 GDSC2 5.5447 8.3171 3.2281 4.0715
ES7 GDSC2 5.5548 7.9358 3.4097 3.0233
SK-ES-1 GDSC2 5.5779 7.6727 3.5412 2.2705
CHSA0108 GDSC2 5.6503 8.4011 3.2543 3.7327
MG-63 GDSC2 5.6962 9.7266 2.6613 7.0879
U2OS GDSC2 5.8508 12.8521 1.2541 14.5488
EW-11 GDSC2 5.8509 12.8567 1.2519 14.5597
CAL-72 GDSC2 5.9603 7.9177 3.6363 1.3188
G-292 clone A141B1 GDSC2 5.9852 11.5086 2.0025 10.2498
NY GDSC2 6.0099 10.1373 2.6719 6.4002
EW-1 GDSC2 6.0894 16.9335 -0.5783 21.8552
EW-16 GDSC2 6.2587 13.6697 1.1473 14.1405
EW-22 GDSC2 6.3046 8.1714 3.6928 0.7889
MHH-ES-1 GDSC2 6.5298 13.2948 1.5154 11.6955
ES6 GDSC2 6.6897 9.4048 3.3776 1.7022
U-CH2 GDSC2 6.7998 8.6614 3.7122 0.4446
ES4 GDSC2 7.0909 9.3108 3.5895 0.634
HuO9 GDSC2 7.2118 9.1621 3.6897 0.3369
⏷ Show the Full List of 38 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 157 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC2 4.2794 7.7791 2.5578 11.262
HT GDSC2 -4.5707 63.9212 -33.1783 53.1252
SU-DHL-1 GDSC2 -2.2423 36.3661 -17.4529 52.234
MC116 GDSC2 -1.0574 71.7662 -33.9817 50.2988
SUP-B8 GDSC2 2.6801 7.1074 1.4023 23.5645
SR GDSC2 2.7994 5.3115 2.3147 17.9597
ALL-PO GDSC2 3.4438 9.6639 0.8879 23.3137
MOLT-4 GDSC2 3.4691 4.3315 3.3886 8.9828
OCI-AML-3 GDSC2 3.6166 10.548 0.6032 24.0407
SU-DHL-6 GDSC2 3.6172 5.2222 3.2034 9.4388
Jurkat GDSC2 3.7518 6.0525 2.9453 10.5269
BE-13 GDSC2 3.7534 9.3824 1.3035 20.1825
SK-MM-2 GDSC2 3.7596 7.6355 2.176 15.2298
BC-1 GDSC2 3.7656 4.9623 3.4702 7.2639
SUP-HD1 GDSC2 3.8222 13.781 -0.8303 28.7911
L-1236 GDSC2 3.84 6.688 2.7166 11.649
GDM-1 GDSC2 3.8895 7.1018 2.557 12.4775
AMO1 GDSC2 3.963 4.9765 3.6625 5.3507
EoL-1 GDSC2 3.9727 4.9467 3.6859 5.1721
DoHH2 GDSC2 3.9952 4.9019 3.729 4.8261
KMS-12-BM GDSC2 4.0082 7.6498 2.3898 13.1275
LAMA-84 GDSC2 4.0576 9.8921 1.3136 19.148
TALL-1 [Human adult T-ALL] GDSC2 4.0863 6.3476 3.1066 8.4072
JeKo-1 GDSC2 4.103 6.7713 2.9104 9.5908
L-540 GDSC2 4.1081 6.6118 2.9942 9.0471
Karpas-231 GDSC2 4.1545 5.3682 3.6535 4.7458
MM1.S GDSC2 4.1586 5.83 3.4278 6.1549
RS4;11 GDSC2 4.1748 6.3538 3.1809 7.6631
NK-92MI GDSC2 4.181 6.7001 3.0134 8.7017
A3/Kawakami GDSC2 4.1961 14.0122 -0.6284 27.0103
MOLM-16 GDSC2 4.2031 5.9923 3.3858 6.2821
CRO-AP2 GDSC2 4.209 5.5154 3.6287 4.729
U-698-M GDSC2 4.231 7.6697 2.5717 11.3202
DB GDSC2 4.2445 7.5386 2.6486 10.8014
CTV-1 GDSC2 4.2482 10.0478 1.3973 18.1149
KE-37 GDSC2 4.2586 6.4337 3.2128 7.2083
ML-2 GDSC2 4.2774 7.6588 2.6162 10.9056
MOLT-13 GDSC2 4.2814 6.4774 3.2102 7.1569
NB4 GDSC2 4.3245 6.3107 3.3297 6.2749
L-428 GDSC2 4.3338 7.2435 2.871 9.1446
MHH-CALL-2 GDSC2 4.3376 5.688 3.6519 4.1971
Kasumi-1 GDSC2 4.3407 6.0079 3.4945 5.1842
CA46 GDSC2 4.351 8.279 2.3675 12.2233
JVM-3 GDSC2 4.3557 11.0122 1.0049 19.8033
JVM-2 GDSC2 4.3637 7.4614 2.7869 9.5865
ST486 GDSC2 4.3691 7.6155 2.7143 10.0254
HAL-01 GDSC2 4.3692 6.5359 3.2541 6.6245
GR-ST GDSC2 4.3733 8.3875 2.3318 12.3761
KMS-11 GDSC2 4.3868 7.0337 3.0197 8.0551
ARH-77 GDSC2 4.3901 5.9487 3.5646 4.6004
BL-41 GDSC2 4.3907 6.7596 3.16 7.1582
BALL-1 GDSC2 4.3914 6.6342 3.2232 6.7566
SIG-M5 GDSC2 4.3941 10.7981 1.1438 18.9935
DND-41 GDSC2 4.4025 6.4572 3.3207 6.1089
697 GDSC2 4.4067 6.4333 3.336 6
SUP-M2 GDSC2 4.4069 6.8667 3.1196 7.3676
LP-1 GDSC2 4.4088 7.2227 2.9433 8.4743
DEL GDSC2 4.4198 6.1242 3.501 4.9198
JJN-3 GDSC2 4.42 5.8356 3.6452 4.0082
EJM GDSC2 4.4266 5.9931 3.5719 4.4534
OCI-AML-2 GDSC2 4.4312 5.8611 3.6415 4.0009
SCC-3 GDSC2 4.4453 7.6529 2.7581 9.5339
CML-T1 GDSC2 4.4557 8.0741 2.5562 10.7611
RPMI-8226 GDSC2 4.4658 9.1907 2.0064 14.0524
BC-3 GDSC2 4.4665 6.1726 3.5142 4.709
RPMI-6666 GDSC2 4.4682 7.529 2.8387 8.9647
Karpas-45 GDSC2 4.4718 5.9481 3.6301 3.9632
CCRF-CEM GDSC2 4.4823 8.3743 2.4278 11.4763
Reh GDSC2 4.4937 6.2413 3.5014 4.7171
K-562 GDSC2 4.5004 7.8365 2.7111 9.6727
MOLT-16 GDSC2 4.5039 10.0178 1.6242 16.1212
RPMI-8866 GDSC2 4.5116 6.3947 3.439 5.0625
SKM-1 GDSC2 4.5255 6.1817 3.5558 4.2903
A4/Fukuda GDSC2 4.5292 6.2465 3.5265 4.465
TUR GDSC2 4.5325 6.2968 3.504 4.5979
EB2 GDSC2 4.5461 6.4129 3.4569 4.859
Raji GDSC2 4.553 8.5447 2.3999 11.4478
H9 GDSC2 4.5545 7.2538 3.045 7.4306
ATN-1 GDSC2 4.5618 6.718 3.3174 5.6958
CTB-1 GDSC2 4.5625 25.9824 -6.3085 37.1763
Karpas-620 GDSC2 4.564 6.7997 3.2785 5.9348
U266B1 GDSC2 4.5683 6.8564 3.2537 6.0797
HL-60 GDSC2 4.5904 6.1857 3.6032 3.8272
WIL2 NS GDSC2 4.604 6.5536 3.4315 4.8689
MY-M12 GDSC2 4.6102 9.2209 2.1083 13.041
RCH-ACV GDSC2 4.6294 9.2568 2.1058 13.0024
NU-DUL-1 GDSC2 4.6508 6.4821 3.5022 4.3086
THP-1 GDSC2 4.6512 7.9311 2.7839 8.8066
OCI-Ly7 GDSC2 4.6663 6.4303 3.5391 4.0407
OCI-M1 GDSC2 4.6913 8.1244 2.719 9.1035
Ramos.2G6.4C10 GDSC2 4.6955 6.4125 3.5693 3.7828
Namalwa GDSC2 4.7014 12.4774 0.5559 20.9037
HEL GDSC2 4.7066 7.9589 2.8132 8.4774
P12-Ichikawa GDSC2 4.723 10.2659 1.6773 15.2021
PF-382 GDSC2 4.7319 6.1889 3.7041 2.8686
P30/OHK GDSC2 4.7375 7.3886 3.1197 6.4837
SU-DHL-4 GDSC2 4.7376 7.6986 2.9662 7.4423
SU-DHL-16 GDSC2 4.747 8.0609 2.7938 8.492
WSU-NHL GDSC2 4.7891 7.1113 3.2948 5.2638
VL51 GDSC2 4.8051 6.828 3.4452 4.2935
HC-1 GDSC2 4.8407 7.747 3.0201 6.8466
NALM-6 GDSC2 4.8491 11.0813 1.3709 16.5111
P32/ISH GDSC2 4.8512 6.3865 3.6904 2.6961
Daudi GDSC2 4.8525 6.4206 3.675 2.7858
Loucy GDSC2 4.8571 7.0535 3.3724 4.6224
VAL GDSC2 4.8624 8.3061 2.7604 8.4033
KCL-22 GDSC2 4.8686 8.7909 2.5251 9.8334
MOLM-13 GDSC2 4.8734 7.0434 3.3889 4.4839
GA-10 GDSC2 4.9075 7.8285 3.0295 6.6251
Karpas-422 GDSC2 4.9229 6.8569 3.5136 3.6117
OPM-2 GDSC2 4.9262 6.6774 3.6017 3.0733
NCI-H929 GDSC2 4.9267 8.027 2.9461 7.0949
KY821 GDSC2 4.9363 6.6398 3.6263 2.9056
Jiyoye GDSC2 4.9482 8.4548 2.7514 8.2435
SUP-B15 GDSC2 4.9571 7.0073 3.4646 3.8355
SU-DHL-5 GDSC2 4.9712 7.2015 3.3808 4.3147
EM-2 GDSC2 4.9862 7.3897 3.3002 4.7736
PL-21 GDSC2 4.9926 7.2366 3.3786 4.2814
LC4-1 GDSC2 5.0112 7.1717 3.4225 3.9752
SU-DHL-10 GDSC2 5.0171 6.3782 3.7992 1.7517
Ku812 GDSC2 5.0236 7.6834 3.184 5.4008
SUP-T1 GDSC2 5.0272 7.0102 3.5104 3.4132
MN-60 GDSC2 5.0316 7.9578 3.0561 6.1674
KOPN-8 GDSC2 5.0426 10.5168 1.8027 13.6339
Karpas-1106P GDSC2 5.0448 8.2453 2.9252 6.941
MHH-PREB-1 GDSC2 5.0596 6.9799 3.546 3.1363
MEG-01 GDSC2 5.0745 7.9675 3.0818 5.9112
DG-75 GDSC2 5.076 8.0087 3.0629 6.0239
NOMO-1 GDSC2 5.1127 6.8035 3.6619 2.3622
TK [Human B-cell lymphoma] GDSC2 5.1206 9.3895 2.419 9.8394
ALL-SIL GDSC2 5.1232 7.4023 3.3875 3.952
CESS GDSC2 5.1805 7.3744 3.4382 3.536
MLMA GDSC2 5.1847 11.1481 1.5985 14.3927
MOLP-8 GDSC2 5.2037 7.2431 3.5145 3.0451
IM-9 GDSC2 5.2129 7.0134 3.6263 2.3892
MHH-CALL-4 GDSC2 5.2348 8.112 3.1231 5.3073
L-363 GDSC2 5.2779 14.8231 -0.1548 22.2907
KM-H2 GDSC2 5.2947 9.1013 2.6865 7.8142
OCI-AML-5 GDSC2 5.2949 6.459 3.9141 0.7863
QIMR-WIL GDSC2 5.3076 14.1803 0.1882 20.8382
Farage GDSC2 5.3773 7.3886 3.5533 2.5203
KG-1 GDSC2 5.3894 7.2085 3.6413 2.0211
Granta-519 GDSC2 5.403 7.5279 3.5052 2.7455
KMOE-2 GDSC2 5.4185 7.5216 3.5172 2.6523
OCI-Ly19 GDSC2 5.4339 8.7945 2.9307 6.0411
RC-K8 GDSC2 5.4945 8.2204 3.2417 4.086
ME1 GDSC2 5.515 6.795 3.8817 0.7092
JSC-1 GDSC2 5.5422 7.2703 3.6976 1.5171
Karpas-299 GDSC2 5.6526 11.054 1.9901 11.0672
RL GDSC2 5.66 39.5095 -12.1696 39.9683
HDLM-2 GDSC2 5.9076 9.7961 2.7666 6.0533
SU-DHL-8 GDSC2 6.0181 7.6608 3.766 0.7386
ROS-50 GDSC2 6.2697 8.7013 3.4635 1.7628
HH [Human lymphoma] GDSC2 6.2718 8.357 3.6052 1.1482
Hs 445 GDSC2 6.3513 8.253 3.6815 0.7952
BONNA-12 GDSC2 6.3819 9.0148 3.3885 1.9817
JURL-MK1 GDSC2 6.4525 8.1621 3.7579 0.4893
⏷ Show the Full List of 157 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
FLO-1 GDSC2 4.4068 7.7848 2.6607 10.2512
KYSE-50 GDSC2 4.5691 15.9834 -1.3041 28.0766
ESO-51 GDSC2 4.6898 10.6862 1.4409 16.5849
KYSE-220 GDSC2 4.6937 7.3496 3.1057 6.6831
TE-12 GDSC2 4.841 9.7096 2.0475 12.7654
HCE-4 GDSC2 5.0344 10.437 1.836 13.4675
OACM5.1 C GDSC2 5.4928 9.3849 2.6873 7.3672
ESO-26 GDSC2 5.7609 13.8959 0.6748 17.5612
KYAE-1 GDSC2 6.1182 8.2231 3.5871 1.3714
OACP4 C GDSC2 6.2788 8.4219 3.5824 1.2351
SK-GT-4 GDSC2 6.9364 15.8254 0.5764 15.3328
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC2 4.7679 8.0318 2.8243 8.2486
Cancer Drug Sensitivity Data Curated from 28 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SJNB-17 GDSC2 4.2298 17.3095 -2.2488 31.4583
SJNB-14 GDSC2 4.2578 6.4509 3.2035 7.2691
Kelly GDSC2 4.4514 6.182 3.4975 4.8553
SK-N-MC-IXC GDSC2 4.4629 5.7878 3.7029 3.5285
CHP-134 GDSC2 4.5852 6.2857 3.5499 4.1742
GOTO GDSC2 4.6454 18.8914 -2.695 31.3861
TGW GDSC2 4.7303 6.4935 3.5548 3.7906
SK-N-BE(2)-M17 GDSC2 4.772 7.3602 3.1596 6.148
SiMa GDSC2 4.8013 7.1356 3.2918 5.2534
SK-N-DZ GDSC2 4.8016 6.3324 3.6829 2.8457
KP-N-YS GDSC2 4.8313 7.4023 3.1829 5.8578
CHP-126 GDSC2 5.0966 6.9142 3.6004 2.7458
NB(TU)1 GDSC2 5.1241 8.3421 2.9348 6.6973
KP-N-YN GDSC2 5.1416 8.3326 2.9519 6.553
SJNB-13 GDSC2 5.1631 10.1395 2.081 11.7313
MHH-NB-11 GDSC2 5.1665 8.0213 3.1201 5.4732
SJNB-10 GDSC2 5.2178 9.4596 2.4561 9.3804
SJNB-7 GDSC2 5.2752 10.1393 2.1644 10.9664
SJNB-5 GDSC2 5.3421 12.8932 0.8539 17.782
CHP-212 GDSC2 5.4052 10.6465 2.0107 11.537
IMR-5 GDSC2 5.8379 14.7461 0.313 18.9727
SK-N-AS GDSC2 5.9471 14.774 0.3807 18.4175
NH-12 GDSC2 5.9781 8.1388 3.553 1.6801
NB69 GDSC2 5.9898 14.2153 0.687 16.9523
LA-N-6 GDSC2 5.9968 8.1052 3.5765 1.5494
SJNB-6 GDSC2 6.1462 7.8122 3.7629 0.657
KP-N-RT-BM-1 GDSC2 6.7377 8.6806 3.6807 0.5595
GI-ME-N GDSC2 6.8503 9.4603 3.4299 1.3399
⏷ Show the Full List of 28 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC2 4.7406 6.9831 3.3221 5.2119
Cancer Drug Sensitivity Data Curated from 46 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OCUB-M GDSC2 3.3981 5.9882 2.6332 13.7155
HCC2218 GDSC2 3.5147 6.0828 2.7031 12.861
HCC1954 GDSC2 3.8286 7.646 2.2327 14.6608
MDA-MB-468 GDSC2 3.8353 6.9609 2.5778 12.5263
MDA-MB-453 GDSC2 3.8691 5.83 3.1637 8.765
MDA-MB-157 GDSC2 3.9047 6.2047 3.0137 9.5803
UACC-893 GDSC2 4.0922 12.1738 0.2029 24.2273
BT-20 GDSC2 4.3059 10.7825 1.0783 19.5888
HCC1419 GDSC2 4.3588 12.1974 0.4149 22.5244
BT-474 GDSC2 4.4472 7.4169 2.8775 8.7798
MRK-nu-1 GDSC2 4.5116 5.9988 3.6358 3.8229
CAL-120 GDSC2 4.5181 6.9815 3.1519 6.8561
DU4475 GDSC2 4.5913 6.5516 3.4228 4.9561
HCC1187 GDSC2 4.6356 6.36 3.551 4.0417
MCF-7 GDSC2 4.7234 11.4099 1.1067 18.2236
HCC1599 GDSC2 4.7373 8.657 2.49 10.3928
MDA-MB-361 GDSC2 4.7463 8.7236 2.464 10.5275
HCC2157 GDSC2 4.8067 6.7235 3.4972 3.9694
CAMA-1 GDSC2 4.8249 7.3164 3.2204 5.64
Evsa-T GDSC2 4.8462 13.6822 0.0712 22.5596
EFM-192A GDSC2 4.8768 10.5039 1.6803 14.7611
MDA-MB-415 GDSC2 4.9384 7.3757 3.2733 5.046
HCC1500 GDSC2 4.9527 13.6828 0.1562 21.9196
HCC70 GDSC2 4.9645 7.8449 3.063 6.2819
T-47D GDSC2 5.0125 9.4778 2.2945 10.8564
HCC1569 GDSC2 5.1105 10.5933 1.8167 13.3774
HCC1937 GDSC2 5.3278 9.3862 2.5713 8.4306
MDA-MB-436 GDSC2 5.3554 10.1182 2.2334 10.369
YMB-1-E GDSC2 5.3986 8.0698 3.2513 4.2116
COLO 824 GDSC2 5.461 8.2458 3.2086 4.3418
CAL-51 GDSC2 5.4612 9.0122 2.8449 6.4952
CAL-85-1 GDSC2 5.4897 9.554 2.6035 7.8721
BT-549 GDSC2 5.4998 9.738 2.5216 8.3356
HCC1806 GDSC2 5.5942 7.6274 3.5704 2.0931
AU565 GDSC2 5.675 8.9105 3.0334 4.9546
HCC1143 GDSC2 5.6893 8.4641 3.249 3.6949
MFM-223 GDSC2 5.7325 11.0934 2.0275 10.6725
EFM-19 GDSC2 5.8127 13.0903 1.1096 15.3634
HDQ-P1 GDSC2 5.8285 8.0228 3.525 2.0026
Hs 578T GDSC2 5.8636 9.3876 2.9296 5.1996
ZR-75-30 GDSC2 6.3816 15.2672 0.4564 17.0734
HCC1428 GDSC2 6.5232 14.277 1.0381 14.0873
JIMT-1 GDSC2 6.5482 8.07 3.8281 0.2739
MDA-MB-330 GDSC2 6.6362 17.0797 -0.2462 19.377
HCC38 GDSC2 6.988 9.0433 3.6469 0.5279
MDA-MB-231 GDSC2 7.1125 9.3214 3.5943 0.6097
⏷ Show the Full List of 46 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 51 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
D-423MG GDSC2 4.175 8.0272 2.3455 12.8828
Hs 683 GDSC2 4.4583 6.1961 3.496 4.8463
AM-38 GDSC2 4.6927 7.5262 3.0173 7.2387
D-247MG GDSC2 4.7712 8.1279 2.7792 8.5204
PFSK-1 GDSC2 4.7747 7.0749 3.3021 5.2532
SK-MG-1 GDSC2 4.7784 7.7953 2.9495 7.4427
NMC-G1 GDSC2 4.8092 8.276 2.7348 8.6971
SF295 GDSC2 4.8203 7.6397 3.0578 6.6627
U-87MG ATCC GDSC2 4.9106 8.7103 2.5969 9.2865
A-172 GDSC2 4.9248 6.8489 3.5187 3.5768
U-251MG GDSC2 4.9353 14.8023 -0.4163 24.1805
KS-1 [Human Krukenberg tumour] GDSC2 4.9566 9.4976 2.2421 11.312
KALS-1 GDSC2 5.0213 7.26 3.387 4.1682
KNS-81-FD GDSC2 5.0641 8.1057 3.0073 6.3919
SF539 GDSC2 5.089 11.0415 1.5781 14.7538
42-MG-BA GDSC2 5.1013 7.6983 3.2309 4.9426
YKG-1 GDSC2 5.1768 6.9826 3.6185 2.4958
8-MG-BA GDSC2 5.1951 10.0011 2.1731 11.1137
D-502MG GDSC2 5.307 10.7452 1.8897 12.4658
T98G GDSC2 5.3195 7.6583 3.3937 3.5303
D-263MG GDSC2 5.3279 9.6518 2.4418 9.2038
GaMG GDSC2 5.3334 8.6052 2.9534 6.1186
D-542MG GDSC2 5.3646 7.2414 3.6123 2.2163
YH-13 GDSC2 5.4098 7.5323 3.5072 2.7227
Becker GDSC2 5.4143 7.2223 3.6491 1.9421
D-245MG GDSC2 5.4282 9.484 2.5946 8.0623
D-336MG GDSC2 5.4382 10.9876 1.8674 12.2677
GB-1 GDSC2 5.4536 9.3261 2.6887 7.4447
Onda 10 GDSC2 5.5059 12.6615 1.093 16.2009
LN-229 GDSC2 5.5377 11.5404 1.669 13.122
DK-MG GDSC2 5.5487 7.5071 3.5982 2.0137
H4 GDSC2 5.5962 17.1059 -1.0416 24.6144
SF126 GDSC2 5.6141 9.5887 2.672 7.1974
D-392MG GDSC2 5.6975 12.6168 1.2576 14.8997
SF268 GDSC2 5.7036 9.2522 2.8912 5.7266
LN-18 GDSC2 5.7588 13.7034 0.7682 17.1349
KNS-42 GDSC2 5.7936 7.5174 3.7202 1.1225
SW1088 GDSC2 5.9288 8.221 3.4926 2.0327
LN-405 GDSC2 5.9487 8.3794 3.4348 2.2961
CAS-1 GDSC2 6.1829 7.4862 3.8981 0.2528
ONS-76 GDSC2 6.2263 11.5158 2.1614 8.8583
SNB-75 GDSC2 6.2775 9.3616 3.1848 3.1207
U-118MG GDSC2 6.3256 8.1878 3.6955 0.7643
D283 Med GDSC2 6.3804 7.7854 3.8661 0.2516
Daoy GDSC2 6.3861 11.9675 2.0522 9.1381
KINGS-1 GDSC2 6.405 13.7479 1.2118 13.4974
M059J GDSC2 6.5747 8.2476 3.7747 0.3865
D-566MG GDSC2 6.8799 8.3689 3.8445 0.1543
Onda 11 GDSC2 6.9089 9.1399 3.5791 0.7677
DBTRG-05MG GDSC2 7.0879 15.1607 0.9982 13.0949
GI-1 GDSC2 7.1582 9.0145 3.7217 0.2903
⏷ Show the Full List of 51 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TGBC24TKB GDSC2 3.9678 7.7272 2.3159 13.7072
ETK-1 GDSC2 5.7645 8.2976 3.3687 2.9106
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MFE-296 GDSC2 4.4396 6.1806 3.4887 4.9429
RL95-2 GDSC2 4.5681 8.8297 2.2698 12.1944
EN GDSC2 4.6063 8.1417 2.6435 9.8009
MFE-280 GDSC2 4.6392 7.8387 2.8205 8.6108
MFE-319 GDSC2 4.8843 6.9369 3.4483 4.0941
KLE GDSC2 5.7113 13.5548 0.806 17.0749
AN3-CA GDSC2 6.0353 18.2679 -1.2797 24.3189
ESS-1 GDSC2 6.7627 8.1081 3.8919 0.1131
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW13 GDSC2 4.5287 6.5308 3.3847 5.3591
KTCTL-140 GDSC2 4.6663 7.7322 2.8946 8.0753
KTCTL-21 GDSC2 4.8802 13.0623 0.4079 21.0547
KMRC-20 GDSC2 4.9794 8.1351 2.9317 7.0563
KTCTL-13 GDSC2 5.0221 7.1887 3.4217 3.9566
BFTC-909 GDSC2 5.0726 10.2606 1.9526 12.7033
ACHN GDSC2 5.1067 12.9566 0.6399 19.4019
CAL-54 GDSC2 5.1241 13.3724 0.4466 20.2203
LB1047-RCC GDSC2 5.1387 11.0502 1.6119 14.4391
SW156 GDSC2 5.1615 8.1566 3.0512 5.903
KTCTL-26A GDSC2 5.1648 7.423 3.405 3.7634
KTCTL-195 GDSC2 5.2377 10.4724 1.9725 12.1687
RCC10RGB GDSC2 5.288 7.1468 3.6103 2.3516
UO-31 GDSC2 5.2988 9.1385 2.6712 7.8968
BB65-RCC GDSC2 5.3176 8.2243 3.1251 5.1214
NCC010 GDSC2 5.3886 9.1126 2.7468 7.2402
LB996-RCC GDSC2 5.4013 8.4972 3.0508 5.392
NCC021 GDSC2 5.4514 8.7496 2.9639 5.8062
SN12C GDSC2 5.4765 12.9955 0.9057 17.1894
A-498 GDSC2 5.5373 7.5584 3.5692 2.1829
HA7-RCC GDSC2 5.6421 10.311 2.3435 9.0642
Caki-1 GDSC2 5.8096 13.013 1.1453 15.1937
VMRC-RCZ GDSC2 5.8504 8.0331 3.5321 1.9385
LB2241-RCC GDSC2 5.8812 8.1756 3.4869 2.1235
TK-10 GDSC2 5.9091 8.6009 3.3156 2.9739
RXF 393L GDSC2 5.9845 8.8261 3.258 3.1665
A-704 GDSC2 6.3229 8.1551 3.7069 0.7269
769-P GDSC2 6.4382 11.9995 2.0711 8.9307
VMRC-RCW GDSC2 6.4768 8.6058 3.5992 0.9989
OS-RC-2 GDSC2 6.8024 8.4908 3.7742 0.2997
786-O GDSC2 6.8616 16.7 0.1005 17.5143
KTCTL-1M GDSC2 7.2845 9.2127 3.6988 0.296
⏷ Show the Full List of 32 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 48 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CCK-81 GDSC2 4.0902 6.2695 3.1489 8.1285
HT-55 GDSC2 4.367 6.0375 3.5014 5.0653
SW626 GDSC2 4.5549 8.5438 2.4018 11.4302
C2BBe1 GDSC2 4.5582 12.5491 0.4035 21.9869
GP5d GDSC2 4.597 6.2489 3.577 3.9746
LS411N GDSC2 4.623 6.2073 3.6169 3.6612
LS513 GDSC2 4.6401 6.2504 3.6083 3.6734
SNU-81 GDSC2 4.6792 7.4074 3.0659 6.9693
NCI-H716 GDSC2 4.766 7.0101 3.3276 5.1162
COLO 320HSR GDSC2 4.7685 7.8494 2.9151 7.6818
HT-29 GDSC2 4.8012 8.2424 2.7454 8.6521
LoVo GDSC2 4.8034 7.0923 3.3146 5.1065
SW1417 GDSC2 4.8115 7.909 2.9183 7.553
DiFi GDSC2 4.8461 8.3273 2.7375 8.5858
SW620 GDSC2 4.8494 9.079 2.3674 10.8411
COLO205 GDSC2 4.8613 7.8565 2.9815 7.0358
SNU-175 GDSC2 4.9034 10.8834 1.5123 15.6082
HT115 GDSC2 4.9251 10.7753 1.5831 15.1646
RKO GDSC2 4.9546 8.2498 2.8571 7.5768
HCT 116 GDSC2 4.9867 6.6816 3.6394 2.7276
SNU-C5 GDSC2 5.0014 7.5772 3.2199 5.231
KM12 GDSC2 5.0135 8.8229 2.6186 8.896
CW-2 GDSC2 5.0443 9.069 2.5202 9.4179
HCC2998 GDSC2 5.0842 8.0119 3.0671 5.9793
SW948 GDSC2 5.1004 7.0258 3.5507 3.0294
HCT 15 GDSC2 5.1591 9.3251 2.4791 9.3842
SNU-C1 GDSC2 5.1884 8.3245 2.9887 6.2231
NCI-H747 GDSC2 5.2021 7.8585 3.2225 4.7779
SNU-1040 GDSC2 5.2111 7.1154 3.5783 2.6643
LS123 GDSC2 5.2233 7.2444 3.5261 2.9421
SW837 GDSC2 5.2718 9.768 2.3442 9.917
CL-11 GDSC2 5.2899 9.4205 2.5274 8.7816
SNU-61 GDSC2 5.3046 8.1937 3.1311 5.1126
SW1116 GDSC2 5.3688 8.9835 2.7954 6.9922
NCI-H508 GDSC2 5.5295 7.7907 3.4606 2.7832
RCM-1 [Human ESC] GDSC2 5.6245 8.6701 3.1138 4.5839
CaR-1 GDSC2 5.6526 8.0837 3.4002 2.9159
MDST8 GDSC2 5.6626 9.6199 2.6897 6.9907
T84 GDSC2 5.7651 7.8383 3.5709 1.8567
SW48 GDSC2 5.8391 8.1276 3.4852 2.1893
SW1463 GDSC2 5.9955 12.612 1.4753 13.0741
LS180 GDSC2 6.0812 7.7314 3.7661 0.6913
SNU-407 GDSC2 6.1441 18.576 -1.3493 24.2826
SK-CO-1 GDSC2 6.3414 8.0312 3.7615 0.5392
SNU-C2B GDSC2 6.3902 16.1759 0.0178 18.8936
LS1034 GDSC2 6.5061 8.0897 3.8052 0.341
SNU-283 GDSC2 6.5276 8.0302 3.8345 0.2674
COLO 678 GDSC2 7.1358 9.7182 3.4549 1.0296
⏷ Show the Full List of 48 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC2 4.9134 7.2971 3.2938 4.9772
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-398 GDSC2 4.1128 8.8991 1.8569 15.9796
JHH-6 GDSC2 4.3621 9.1563 1.9381 14.7544
Hep 3B2.1-7 GDSC2 4.4715 9.095 2.0588 13.728
Hep-G2/C3A GDSC2 4.5358 6.2061 3.5516 4.2899
JHH-2 GDSC2 4.6126 6.3279 3.5497 4.1064
JHH-4 GDSC2 4.6624 14.0486 -0.2607 24.3613
Huh-7 GDSC2 4.685 8.7944 2.3805 11.2013
SNU-449 GDSC2 4.8192 9.0745 2.3463 11.0483
JHH-7 GDSC2 4.8971 10.4048 1.7456 14.3421
JHH-1 GDSC2 4.9459 7.4002 3.2667 5.0697
HLE GDSC2 4.9527 9.1545 2.4091 10.3215
HuH-1 GDSC2 4.966 8.1769 2.9013 7.2761
SK-HEP-1 GDSC2 5.6182 8.4331 3.22 3.9847
SNU-387 GDSC2 6.0656 8.7774 3.3247 2.6976
SNU-423 GDSC2 6.3484 9.4574 3.1816 3.0374
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 166 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H23 GDSC2 3.5129 5.4313 3.0036 11.0412
NCI-H526 GDSC2 3.5658 5.4268 3.059 10.5056
NCI-H2122 GDSC2 3.6498 7.3094 2.2367 15.233
BEN GDSC2 3.7043 10.1454 0.8807 22.4639
NCI-H1581 GDSC2 3.9748 6.9183 2.7242 11.1621
A-427 GDSC2 4.0071 9.5869 1.4227 18.7286
NCI-H1963 GDSC2 4.0616 6.9886 2.7658 10.6271
DMS 53 GDSC2 4.1062 6.2037 3.1957 7.7836
Calu-3 GDSC2 4.3063 6.817 3.0614 8.0247
NCI-H211 GDSC2 4.3081 8.0485 2.4471 11.8612
RERF-LC-MS GDSC2 4.3085 9.6635 1.6399 16.6114
NCI-H2081 GDSC2 4.3475 6.1735 3.4174 5.6534
SBC-5 GDSC2 4.3785 5.6933 3.6828 3.8854
NCI-H1437 GDSC2 4.4056 6.3511 3.3762 5.7489
NCI-H810 GDSC2 4.4072 6.9748 3.0659 7.7063
NCI-H1155 GDSC2 4.416 7.5346 2.7933 9.3964
NCI-H2171 GDSC2 4.4221 5.8826 3.6235 4.1394
IST-SL2 GDSC2 4.4732 7.6387 2.7878 9.2694
NCI-H524 GDSC2 4.4866 5.9753 3.6281 3.9368
NCI-H838 GDSC2 4.4994 6.4782 3.3879 5.4177
Ms-1 GDSC2 4.5184 6.6637 3.3105 5.8548
NCI-H292 GDSC2 4.5247 9.9843 1.6579 15.8741
HOP-92 GDSC2 4.5573 8.1476 2.6016 10.1952
NCI-H1105 GDSC2 4.5627 6.1677 3.5912 3.9722
NCI-H2141 GDSC2 4.5732 6.5877 3.391 5.2029
NCI-H1770 GDSC2 4.5741 7.007 3.1833 6.5071
UMC-11 GDSC2 4.5776 9.6422 1.8717 14.5132
NCI-H250 GDSC2 4.6087 6.886 3.2704 5.8691
NCI-H146 GDSC2 4.6217 7.2597 3.0948 6.9383
NCI-H1048 GDSC2 4.6278 7.4886 2.9857 7.6071
NCI-H345 GDSC2 4.6401 6.1732 3.6463 3.437
NCI-H2029 GDSC2 4.6436 6.7402 3.3693 5.1587
Calu-6 GDSC2 4.6457 7.3162 3.0853 6.935
CAL-12T GDSC2 4.6719 10.0122 1.7629 14.8657
NCI-H1092 GDSC2 4.7022 6.5243 3.5193 4.0772
DMS 114 GDSC2 4.7025 6.3651 3.5976 3.5911
NCI-H1694 GDSC2 4.7149 6.5019 3.5396 3.9213
SBC-1 GDSC2 4.7523 6.5948 3.5211 3.9476
NCI-H209 GDSC2 4.7571 8.0125 2.8256 8.2687
NCI-H82 GDSC2 4.7571 6.5585 3.5423 3.8058
NCI-H510A GDSC2 4.7645 6.7179 3.4697 4.2369
LC-1/sq GDSC2 4.7713 7.0592 3.3074 5.2289
Lu-65 GDSC2 4.7795 6.6857 3.4962 4.0381
NCI-H2461 GDSC2 4.8133 9.8547 1.9536 13.3855
NCI-H748 GDSC2 4.8209 7.4837 3.1352 6.1796
Lu-134-A GDSC2 4.8493 8.3018 2.7526 8.4846
COR-L23 GDSC2 4.8734 6.9884 3.4156 4.3193
EPLC-272H GDSC2 4.8785 7.2707 3.2817 5.1326
CPC-N GDSC2 4.8837 7.018 3.4085 4.3397
ABC-1 GDSC2 4.8887 11.0487 1.4185 16.1505
NCI-H647 GDSC2 4.9025 7.1115 3.3763 4.4948
A-549 GDSC2 4.9085 13.4299 0.2471 21.6632
COR-L303 GDSC2 4.9089 6.9642 3.4522 4.0162
IST-SL1 GDSC2 4.9209 7.4175 3.2404 5.2891
NCI-H1975 GDSC2 4.9351 7.646 3.1391 5.8814
NCI-H1436 GDSC2 4.9358 7.0269 3.4406 4.0277
PC-14 GDSC2 4.9479 8.1507 2.9009 7.3226
LB647-SCLC GDSC2 4.9493 6.8884 3.5164 3.5387
SHP-77 GDSC2 4.9529 11.4929 1.2478 16.8676
COR-L311 GDSC2 4.958 6.9882 3.4744 3.7743
NCI-H2172 GDSC2 4.9595 6.7101 3.6082 2.9666
DMS 273 GDSC2 5.0024 7.5411 3.2381 5.1171
NCI-H596 GDSC2 5.0153 7.0388 3.4888 3.5668
NCI-H2444 GDSC2 5.0295 7.6938 3.1831 5.3932
NCI-H1876 GDSC2 5.0477 7.397 3.3391 4.4015
NCI-H1915 GDSC2 5.0789 7.0471 3.5267 3.2124
IA-LM GDSC2 5.084 7.6332 3.2503 4.8625
SBC-3 GDSC2 5.1039 7.8228 3.1726 5.2911
HCC44 GDSC2 5.1347 7.5787 3.311 4.3873
NCI-H1651 GDSC2 5.1412 10.9688 1.6541 14.2018
COR-L321 GDSC2 5.1606 9.4573 2.4152 9.7639
NCI-H2135 GDSC2 5.1702 8.8344 2.7276 7.8539
Lu-99A GDSC2 5.175 8.1952 3.0419 5.9293
EMC-BAC-2 GDSC2 5.1827 9.9055 2.211 10.9221
NCI-H1944 GDSC2 5.1857 10.4805 1.9295 12.5457
Lu-139 GDSC2 5.1959 8.7269 2.7985 7.3628
NCI-H2595 GDSC2 5.201 8.003 3.1525 5.2025
NCI-H1993 GDSC2 5.2126 10.9822 1.7018 13.7543
COLO 668 GDSC2 5.218 7.369 3.4647 3.3081
EMC-BAC-1 GDSC2 5.2409 9.2894 2.5562 8.7245
VMRC-LCD GDSC2 5.2419 9.4105 2.4976 9.0737
NCI-H2023 GDSC2 5.2598 8.5768 2.9163 6.5031
HCC827 GDSC2 5.2637 7.2577 3.5449 2.7616
NCI-H740 GDSC2 5.2836 8.7686 2.8401 6.9116
NCI-H720 GDSC2 5.2887 8.7 2.8769 6.6779
EKVX GDSC2 5.3014 12.9048 0.817 18.0632
NCI-H522 GDSC2 5.3307 10.9496 1.8066 12.8734
NCI-H3255 GDSC2 5.3414 10.5584 2.0071 11.7132
NCI-H1623 GDSC2 5.3854 8.8878 2.853 6.6099
HCC15 GDSC2 5.4553 11.7652 1.4975 14.2479
LK-2 GDSC2 5.4709 15.1964 -0.1899 21.9284
NCI-H2591 GDSC2 5.5 12.6224 1.108 16.1413
NCI-H841 GDSC2 5.5116 11.4411 1.6986 13.0239
NCI-H196 GDSC2 5.5346 9.2147 2.7974 6.6227
SW1271 GDSC2 5.5566 9.3391 2.7528 6.8411
NCI-H1299 GDSC2 5.5642 11.005 1.9506 11.4973
NCI-H2110 GDSC2 5.5747 8.3427 3.2349 3.9775
SK-MES-1 GDSC2 5.6238 8.1387 3.3584 3.1937
HCC78 GDSC2 5.6367 13.5098 0.7724 17.4169
NCI-H358 GDSC2 5.6371 10.2792 2.3554 9.006
NCI-H3122 GDSC2 5.641 11.8209 1.6069 13.2082
NCI-H2810 GDSC2 5.6451 9.4625 2.7531 6.6542
NCI-H1666 GDSC2 5.6572 9.2957 2.8404 6.1162
NCI-H513 GDSC2 5.6616 10.0589 2.4785 8.2329
NCI-H2804 GDSC2 5.663 8.6242 3.1592 4.2516
NCI-H661 GDSC2 5.6701 7.6856 3.5863 1.9054
NCI-H2731 GDSC2 5.6702 8.0481 3.4263 2.7458
NCI-H1355 GDSC2 5.6733 16.3354 -0.5991 22.9308
NCI-H2803 GDSC2 5.707 10.2329 2.426 8.4412
NCI-H2369 GDSC2 5.719 8.2854 3.3478 3.0962
NCI-H2373 GDSC2 5.7255 8.3789 3.3094 3.2971
DMS 79 GDSC2 5.7379 7.8364 3.5572 1.9611
RERF-LC-Sq1 GDSC2 5.7416 9.6745 2.7162 6.6729
Lu-165 GDSC2 5.7662 9.4964 2.8166 6.0384
NCI-H2170 GDSC2 5.7722 8.3005 3.3718 2.8819
NCI-H2196 GDSC2 5.7805 7.5212 3.7123 1.1707
NCI-H2291 GDSC2 5.7873 8.1391 3.4519 2.4338
NCI-H446 GDSC2 5.7939 7.5037 3.7259 1.0972
EBC-1 GDSC2 5.7952 8.7427 3.1852 3.8712
SW1573 GDSC2 5.803 8.3531 3.3658 2.8664
RERF-LC-KJ GDSC2 5.8053 10.071 2.5698 7.3962
NCI-H1568 GDSC2 5.8116 11.9675 1.6583 12.5281
Lu-135 GDSC2 5.8232 7.6692 3.672 1.3056
HCC33 GDSC2 5.8283 8.1674 3.462 2.3228
NCI-H1869 GDSC2 5.8409 9.128 3.0359 4.6345
LC-2/ad GDSC2 5.8666 8.5322 3.3221 3.0034
NCI-H1781 GDSC2 5.8759 14.954 0.2389 19.1939
NCI-H2227 GDSC2 5.8929 7.8863 3.6161 1.4837
NCI-H650 GDSC2 5.8938 11.0378 2.1665 9.5277
NCI-H2087 GDSC2 5.9084 8.2501 3.4693 2.1762
HCC366 GDSC2 5.9123 11.1864 2.1076 9.8203
NCI-H2085 GDSC2 5.9472 11.0028 2.2197 9.1113
NCI-H2030 GDSC2 6.0123 8.9935 3.1991 3.4402
NCI-H460 GDSC2 6.0195 7.2611 3.9164 0.2744
LCLC-97TM1 GDSC2 6.051 13.7479 0.9608 15.5239
NCI-H1792 GDSC2 6.0569 11.2598 2.1706 9.1565
NCI-H2405 GDSC2 6.0909 9.4722 3.029 4.242
LOU-NH91 GDSC2 6.1004 8.1235 3.6193 1.2504
NCI-H1755 GDSC2 6.121 8.2287 3.5862 1.3727
NCI-H1793 GDSC2 6.1855 12.5714 1.628 11.8457
NCI-H1734 GDSC2 6.1895 8.2639 3.6044 1.2272
HOP-62 GDSC2 6.1912 8.9555 3.315 2.5749
NCI-H290 GDSC2 6.1928 13.1816 1.3378 13.3346
HARA [Human squamous cell lung carcinoma] GDSC2 6.2052 8.5254 3.5048 1.6459
NCI-H1836 GDSC2 6.2071 7.5109 3.8983 0.2434
LXF 289 GDSC2 6.2257 12.8792 1.5073 12.3905
NCI-H2795 GDSC2 6.2329 14.7597 0.5973 16.7896
NCI-H1563 GDSC2 6.2391 12.4865 1.7058 11.3164
NCI-H2228 GDSC2 6.2624 9.5015 3.1146 3.5095
NCI-H1435 GDSC2 6.3196 8.6677 3.5018 1.5381
SK-LU-1 GDSC2 6.3943 12.318 1.8911 9.9963
NCI-H2869 GDSC2 6.4172 9.1973 3.3296 2.2174
NCI-H727 GDSC2 6.4318 15.7822 0.2409 17.8824
COR-L32 GDSC2 6.4472 8.5307 3.6155 0.9615
NCI-H2722 GDSC2 6.5782 10.8361 2.6977 5.2474
LCLC-103H GDSC2 6.6069 15.19 0.6543 15.6923
NCI-H2818 GDSC2 6.6475 9.2066 3.4381 1.4879
NCI-H322M GDSC2 6.6902 9.7949 3.2161 2.4301
NCI-H226 GDSC2 6.6978 17.0046 -0.1649 18.9277
KNS-62 GDSC2 6.7729 14.9539 0.884 14.2811
NCI-H1693 GDSC2 6.8821 8.5936 3.7676 0.2869
NCI-H520 GDSC2 7.09 17.1079 0.0631 17.1812
NCI-H1650 GDSC2 7.1045 14.9948 1.0883 12.6357
COR-L105 GDSC2 7.2919 18.39 -0.417 18.6203
ChaGo-K-1 GDSC2 7.4958 21.7119 -1.8907 23.0063
NCI-H441 GDSC2 7.8878 19.9665 -0.7649 18.6812
⏷ Show the Full List of 166 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC2 4.7171 7.4624 3.0677 6.8607
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE-10 GDSC2 4.4709 6.7763 3.2165 6.5771
TE-9 GDSC2 4.7473 6.5704 3.5294 3.9079
OE19 GDSC2 4.7852 6.6411 3.5221 3.8655
TE-4 GDSC2 4.868 10.1112 1.8688 13.7242
EC-GI-10 GDSC2 4.8897 7.0012 3.4209 4.2501
TE-1 GDSC2 4.9565 7.2727 3.3361 4.6202
TE-11 GDSC2 5.0482 8.0107 3.0422 6.2142
TE-5 GDSC2 5.1768 9.3014 2.5037 9.1929
OE33 GDSC2 5.1878 8.3757 2.9635 6.3777
TE-6 GDSC2 5.304 9.3836 2.5556 8.5799
TE-8 GDSC2 5.4639 10.1778 2.2826 9.8251
KYSE-140 GDSC2 5.6679 9.079 2.9498 5.4544
KYSE-70 GDSC2 5.709 9.5511 2.7533 6.5221
KYSE-270 GDSC2 5.9538 11.2488 2.1061 9.7391
KYSE-180 GDSC2 5.9945 11.5195 2.0037 10.2234
KYSE-410 GDSC2 6.02 15.1008 0.2739 18.6995
KYSE-520 GDSC2 6.2183 13.9738 0.9706 15.0907
OE21 GDSC2 6.4149 8.7276 3.5227 1.355
TE-15 GDSC2 6.6679 9.3332 3.3965 1.6431
COLO 680N GDSC2 6.7642 14.9736 0.8685 14.3717
KYSE-510 GDSC2 7.9692 17.8159 0.3187 14.3901
KYSE-450 GDSC2 8.1247 18.7357 -0.0154 15.4509
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 25 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHOS-4 GDSC2 3.1985 8.5094 1.2314 22.481
OV-90 GDSC2 4.1815 7.9243 2.4024 12.5146
A2780 GDSC2 4.47 8.334 2.4379 11.4492
OVK18 GDSC2 4.5308 6.5143 3.3946 5.2913
Caov-3 GDSC2 4.6109 6.0558 3.6824 3.2824
OVISE GDSC2 4.9598 8.0475 2.9603 6.9268
OVCAR-8 GDSC2 4.9784 6.8363 3.5608 3.2114
OVCAR-3 GDSC2 4.9801 7.9976 2.9996 6.6362
ES-2 GDSC2 5.1221 11.9341 1.1604 16.8572
TOV-21G GDSC2 5.2149 11.1127 1.639 14.094
TOV-112D GDSC2 5.2655 10.4673 1.9958 11.9657
OV56 GDSC2 5.3663 9.6029 2.4931 8.8087
EFO-21 GDSC2 5.5449 10.0637 2.3954 8.9786
TYK-nu GDSC2 5.6274 11.45 1.7786 12.3059
JHOS-2 GDSC2 5.6759 9.9672 2.5324 7.8865
Kuramochi GDSC2 6.0939 13.6269 1.0508 14.9891
OAW28 GDSC2 6.228 11.5736 2.1351 9.0011
OVCAR-5 GDSC2 6.4884 13.0418 1.6085 11.3001
SK-OV-3 GDSC2 6.5195 7.8949 3.8788 0.1849
IGROV-1 GDSC2 6.6185 18.4537 -0.9333 21.8808
OVCAR-4 GDSC2 6.7454 12.7142 1.9326 9.0787
DOV13 GDSC2 6.7486 8.1346 3.878 0.1336
EFO-27 GDSC2 7.1051 14.504 1.3215 11.5071
OAW42 GDSC2 7.9941 18.1532 0.1751 14.9334
OVTOKO GDSC2 9.036 19.8383 0.0521 13.5785
⏷ Show the Full List of 25 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 27 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HPAC GDSC2 4.0135 7.4892 2.4745 12.5906
Capan-1 GDSC2 4.6692 6.6877 3.4145 4.8108
SUIT-2 GDSC2 4.7247 7.7587 2.9266 7.7231
BxPC-3 GDSC2 4.799 8.7146 2.5094 10.1108
KP-4 GDSC2 4.8889 9.0019 2.436 10.3228
SU.86.86 GDSC2 4.9107 7.7691 3.061 6.4224
HPAF-II GDSC2 4.9605 7.5409 3.2086 5.3935
MZ-PC-1 GDSC2 5.157 8.1505 3.051 5.914
PL4 GDSC2 5.1646 7.3769 3.4267 3.635
Panc 02.03 GDSC2 5.1802 9.9083 2.2078 10.9473
QGP-1 GDSC2 5.1983 10.6184 1.8709 12.846
MIA PaCa-2 GDSC2 5.2076 8.8658 2.7391 7.6964
KP-2 GDSC2 5.217 7.8459 3.2385 4.6508
HuP-T4 GDSC2 5.2405 8.3393 3.0177 5.9321
PaTu 8902 GDSC2 5.3208 8.7928 2.8542 6.7437
PSN1 GDSC2 5.3531 8.7993 2.8734 6.5573
CFPAC-1 GDSC2 5.4973 10.552 2.1238 10.6686
Panc 08.13 GDSC2 5.5695 7.8515 3.4565 2.7406
KP-3 GDSC2 5.6687 9.9231 2.5487 7.8067
Panc 10.05 GDSC2 5.6797 10.3793 2.3365 9.021
DAN-G GDSC2 5.8292 12.4893 1.4161 13.7686
AsPC-1 GDSC2 6.0575 13.5535 1.0605 15.0263
Capan-2 GDSC2 6.058 11.8015 1.9115 10.595
HuP-T3 GDSC2 6.1553 9.2451 3.1682 3.3866
KP-1N GDSC2 6.2114 8.3339 3.5864 1.2821
PaTu 8988t GDSC2 7.1745 21.1961 -1.872 23.5986
YAPC GDSC2 7.5564 20.0973 -1.0598 20.334
⏷ Show the Full List of 27 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MSTO-211H GDSC2 4.6698 10.3065 1.6144 15.6998
NCI-H2052 GDSC2 4.9089 12.1056 0.9078 18.6834
NCI-H28 GDSC2 5.246 10.8895 1.7729 13.2748
MPP 89 GDSC2 5.3155 10.288 2.121 11.1205
IST-Mes1 GDSC2 6.7945 14.3333 1.1967 12.7424
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LNCaP clone FGC GDSC2 4.3219 9.3689 1.7984 15.6787
VCaP GDSC2 4.5272 8.1151 2.5936 10.3284
22Rv1 GDSC2 4.6255 6.3527 3.5471 4.0906
DU145 GDSC2 4.645 7.2631 3.1112 6.7743
PC-3 GDSC2 5.1362 9.2366 2.5057 9.2795
NCI-H660 GDSC2 5.8989 7.2381 3.877 0.4435
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC2 5.9675 10.8476 2.3077 8.5685
Cancer Drug Sensitivity Data Curated from 54 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
GAK GDSC2 4.3832 7.62 2.7237 9.926
A-431 GDSC2 4.5231 6.948 3.1725 6.7122
DJM-1 GDSC2 4.5855 7.5028 2.9454 7.9725
SK-MEL-5 GDSC2 4.5873 7.7364 2.8305 8.6876
MZ-MEL-2 GDSC2 4.593 10.3431 1.5341 16.358
IGR-37 GDSC2 4.5954 6.7229 3.3411 5.4588
G-mel GDSC2 4.6751 6.5785 3.4727 4.433
SK-MEL-3 GDSC2 4.6883 7.6938 2.9307 7.792
SK-MEL-31 GDSC2 4.7632 22.7453 -4.5247 34.4427
SK-MEL-28 GDSC2 4.7651 13.8077 -0.0569 23.2942
IGR-1 GDSC2 4.8427 9.313 2.246 11.5877
G-361 GDSC2 4.8657 14.9732 -0.5576 24.8732
A2058 GDSC2 4.8877 10.8995 1.492 15.7604
A101D GDSC2 4.8897 7.2791 3.2856 5.0826
UACC-257 GDSC2 4.9844 7.0382 3.4683 3.7547
VMRC-MELG GDSC2 4.9926 7.0913 3.4484 3.858
A-388 GDSC2 5.0004 8.0196 3.0035 6.5636
COLO 783 GDSC2 5.1023 6.7631 3.6741 2.3108
CHL-1 GDSC2 5.1065 8.0939 3.0431 6.0757
451Lu GDSC2 5.1174 8.6672 2.7713 7.7117
LOX-IMVI GDSC2 5.1787 8.3093 2.9893 6.2412
CP50-MEL-B GDSC2 5.2114 11.0514 1.6666 13.9514
IPC-298 GDSC2 5.2357 12.4443 0.9949 17.3795
SK-MEL-2 GDSC2 5.2574 6.3009 3.9607 0.6223
Hs 938.T GDSC2 5.2656 9.2013 2.617 8.3002
CP66-MEL GDSC2 5.286 7.4269 3.4804 3.0909
SH-4 GDSC2 5.3118 7.9295 3.2613 4.3224
COLO 800 GDSC2 5.3717 9.424 2.584 8.2536
WM35 GDSC2 5.4088 9.7079 2.4722 8.8354
COLO 679 GDSC2 5.4132 7.1174 3.6947 1.7048
MZ-MEL-7 GDSC2 5.4247 7.6249 3.4738 2.8841
M14 GDSC2 5.4793 7.7379 3.4549 2.8978
COLO 792 GDSC2 5.5375 9.1158 2.8467 6.3243
WT2-iPS GDSC2 5.575 8.2908 3.2591 3.8383
COLO 829 GDSC2 5.6711 12.898 1.0997 15.7567
Mel JuSo GDSC2 5.7298 7.6008 3.6539 1.4966
LB373-MEL-D GDSC2 5.8748 7.3174 3.8367 0.5915
LB2518-MEL GDSC2 5.8974 7.6746 3.7056 1.082
WM1552C GDSC2 6.0356 8.1872 3.5616 1.5743
WM793 GDSC2 6.1463 8.0972 3.6514 1.0741
SK-MEL-30 GDSC2 6.1919 7.488 3.9008 0.2436
WM278 GDSC2 6.2437 14.1769 0.8897 15.4174
RPMI-7951 GDSC2 6.256 8.0426 3.7215 0.7231
UACC-62 GDSC2 6.2601 7.7218 3.843 0.353
RVH-421 GDSC2 6.3622 14.0473 1.0368 14.4475
MMAc-SF GDSC2 6.403 7.8908 3.8371 0.3073
Mel Ho GDSC2 6.4356 9.1944 3.3401 2.1458
WM115 GDSC2 6.4374 7.7647 3.8942 0.18
Hs 940.T GDSC2 6.5173 8.1273 3.7959 0.3587
A-375 GDSC2 6.5213 13.2453 1.5334 11.621
HMV-II GDSC2 6.6276 9.0188 3.5041 1.2393
HT-144 GDSC2 6.9175 22.8183 -2.8623 26.6848
SK-MEL-24 GDSC2 7.4494 14.8127 1.3975 10.4842
EquiPSC Line K2 GDSC2 6.1854 8.7358 3.4063 2.1309
⏷ Show the Full List of 54 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC2 3.4951 6.8409 2.321 15.259
Cancer Drug Sensitivity Data Curated from 20 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Rh41 GDSC2 4.2497 6.2651 3.2895 6.7496
KYM-1 GDSC2 4.4695 8.0388 2.5849 10.544
TE 441.T GDSC2 4.5711 6.4333 3.466 4.7367
A-204 GDSC2 4.6204 7.0993 3.1735 6.4473
G-402 GDSC2 4.6227 7.8889 2.7825 8.892
EW-8 GDSC2 4.8723 6.8228 3.4952 3.8343
SW982 GDSC2 5.0443 10.4087 1.8576 13.3193
MES-SA GDSC2 5.095 10.8242 1.6905 14.1219
SK-LMS-1 GDSC2 5.4254 10.6053 2.0457 11.288
STS-0421 GDSC2 5.4596 8.8921 2.9013 6.1623
HT-1080 GDSC2 5.4878 10.1875 2.2948 9.698
SK-UT-1 GDSC2 5.5098 9.5638 2.6128 7.7731
RKN GDSC2 5.6903 7.9654 3.4746 2.4567
SW684 GDSC2 5.7304 9.6992 2.6971 6.8079
RD GDSC2 5.8747 9.3141 2.9707 4.9448
G-401 GDSC2 5.8865 17.0083 -0.7692 23.0052
Rh30 GDSC2 5.9329 9.2578 3.0323 4.492
VA-ES-BJ GDSC2 5.9847 11.6085 1.954 10.5203
SW872 GDSC2 5.992 13.8702 0.8581 16.1518
GCT GDSC2 6.2258 13.6452 1.1359 14.2704
⏷ Show the Full List of 20 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 25 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-5 GDSC2 4.2616 21.0453 -4.0901 34.9068
KATO III GDSC2 4.3303 6.3679 3.3059 6.4082
MKN45 GDSC2 4.4045 5.9128 3.5942 4.373
RF-48 GDSC2 4.4718 10.1113 1.5512 16.6162
GCIY GDSC2 4.5149 6.3697 3.4541 4.9588
ECC10 GDSC2 4.5553 8.5245 2.4118 11.3682
ECC12 GDSC2 4.6784 7.6023 2.9686 7.5809
AGS GDSC2 4.6845 11.9412 0.8101 19.7811
NUGC-4 GDSC2 4.7708 7.0125 3.3299 5.09
SNU-1 GDSC2 4.8317 8.2238 2.7778 8.3734
MKN1 GDSC2 4.842 8.0643 2.8645 7.81
NUGC-3 GDSC2 4.8422 12.2931 0.7612 19.5661
23132/87 GDSC2 4.8845 11.3396 1.2702 16.9392
IM95 GDSC2 4.9505 9.1435 2.4128 10.3044
NCI-N87 GDSC2 5.2122 13.8519 0.277 20.7163
HGC-27 GDSC2 5.2296 8.2686 3.0442 5.7955
OCUM-1 GDSC2 5.3933 11.3703 1.6459 13.6032
MKN28 GDSC2 5.5668 12.1997 1.3663 14.6608
SK-GT-2 GDSC2 5.5692 9.3732 2.7449 6.8609
SCH GDSC2 5.611 13.2165 0.8979 16.8881
TMK-1 GDSC2 5.7113 8.0484 3.4496 2.5579
RERF-GC-1B GDSC2 5.898 15.0652 0.2006 19.3011
Hs 746.T GDSC2 6.1598 12.5988 1.597 12.066
MKN7 GDSC2 6.7999 19.2032 -1.1682 22.2572
SNG-M GDSC2 5.2722 8.2253 3.0941 5.4023
⏷ Show the Full List of 25 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 14 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HTC-C3 GDSC2 2.7796 6.5972 1.7361 21.3515
IHH-4 GDSC2 4.8766 8.1027 2.8716 7.6795
CAL-62 GDSC2 5.1249 9.083 2.5729 8.9008
8305C GDSC2 5.2675 9.3563 2.5427 8.7427
ML-1 [Human leukemia] GDSC2 5.2817 9.7726 2.3492 9.8635
K5 GDSC2 5.595 9.4093 2.745 6.8062
ASH-3 GDSC2 5.7285 7.6614 3.6275 1.6252
B-CPAP GDSC2 5.8479 11.7693 1.7806 11.781
KMH-2 GDSC2 6.0018 11.6685 1.9369 10.5775
WRO GDSC2 6.0867 14.5626 0.5875 17.1741
TT2609-C02 GDSC2 6.2115 11.0337 2.3798 7.6664
BHT-101 GDSC2 6.2368 13.1055 1.4055 12.8913
8505C GDSC2 6.4861 17.2296 -0.4292 20.4005
FTC-133 GDSC2 6.495 12.377 1.9296 9.585
⏷ Show the Full List of 14 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 38 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HSC-4 GDSC2 3.9764 4.7297 3.7884 4.5385
BICR 78 GDSC2 4.2774 8.4859 2.2027 13.4399
BB30-HNC GDSC2 4.3047 12.5974 0.1698 23.7176
OSC-19 GDSC2 4.4091 9.2609 1.9247 14.694
KON GDSC2 4.4604 8.2656 2.4643 11.3144
PCI-15A GDSC2 4.476 9.7934 1.7135 15.7042
CAL-33 GDSC2 4.5421 6.9507 3.1862 6.5745
SCC-4 GDSC2 4.5582 7.4693 2.9406 8.0766
PCI-06A GDSC2 4.6722 11.3105 1.1151 18.3268
Detroit 562 GDSC2 4.6739 7.9683 2.7831 8.7511
SCC-15 GDSC2 4.6784 6.7437 3.3938 4.9179
Ca9-22 GDSC2 4.6835 7.1136 3.2148 6.0255
LB771-HNC GDSC2 4.7181 9.2397 2.1849 12.2876
HO-1-N-1 GDSC2 4.7393 8.4489 2.5951 9.7427
CAL-27 GDSC2 4.8695 7.053 3.3815 4.538
BICR 10 GDSC2 4.8923 12.6844 0.606 20.1415
BB49-HNC GDSC2 4.9039 9.0234 2.4369 10.2789
HSC-2 GDSC2 4.9316 7.3199 3.2956 4.9248
SAS GDSC2 4.9675 11.5957 1.2081 17.0314
KOSC-2 GDSC2 5.234 9.6729 2.3632 9.8955
SCC-25 GDSC2 5.2683 10.5234 1.9702 12.1054
UPCI-SCC-090 GDSC2 5.3225 16.9217 -1.1648 25.6844
BICR 31 GDSC2 5.3408 8.7675 2.8803 6.5425
BICR 22 GDSC2 5.3516 15.61 -0.4886 23.3451
PCI-04B GDSC2 5.4 8.0728 3.2508 4.2119
HSC-3 GDSC2 5.4386 8.0833 3.2704 4.0238
BHY GDSC2 5.5351 9.753 2.5389 8.1549
PE/CA-PJ15 GDSC2 5.6632 8.5134 3.2105 3.9582
DOK GDSC2 5.7217 10.676 2.2223 9.5872
JHU-029 GDSC2 5.8712 10.3066 2.5014 7.6564
JHU-011 GDSC2 6.0526 11.0605 2.2629 8.6457
JHU-022 GDSC2 6.0643 11.6248 2.0007 10.0891
SAT [Human HNSCC] GDSC2 6.1407 11.6855 2.0234 9.801
SKN-3 GDSC2 6.2436 11.9831 1.9503 9.9867
FaDu GDSC2 6.3511 14.5315 0.7935 15.6246
NCI-H3118 GDSC2 6.6397 8.7849 3.6008 0.8721
SCC-9 GDSC2 6.8422 17.6961 -0.3989 19.5021
OSC-20 GDSC2 7.0997 16.6563 0.2882 16.2334
⏷ Show the Full List of 38 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 14 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HT-1197 GDSC2 4.4656 6.6837 3.2586 6.3257
BFTC-905 GDSC2 4.4909 7.5977 2.8227 9.0017
647V GDSC2 4.6256 6.1275 3.6581 3.3984
SW780 GDSC2 4.7429 11.5787 1.0381 18.5107
KU-19-19 GDSC2 4.754 11.7851 0.9441 18.9407
RT-112 GDSC2 4.7628 8.6441 2.5164 10.1634
RT-4 GDSC2 5.1845 11.01 1.6668 14.0197
J82 GDSC2 5.4173 8.8029 2.9155 6.1665
639V GDSC2 5.5125 11.3088 1.7642 12.6611
T24 GDSC2 5.7476 10.5922 2.2807 9.1942
SW1710 GDSC2 5.826 9.4265 2.8878 5.5102
5637 GDSC2 6.1824 8.3885 3.5502 1.4672
CAL-29 GDSC2 6.2723 8.9531 3.3587 2.2541
TCCSUP GDSC2 6.3254 11.8601 2.0633 9.1995
⏷ Show the Full List of 14 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 36 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JEG-3 GDSC2 3.9954 6.2735 3.0623 8.9776
C-33 A GDSC2 4.2795 9.2683 1.8133 15.7207
PA-1 GDSC2 4.3308 6.368 3.3063 6.4045
DoTc2 4510 GDSC2 4.3469 7.3575 2.8249 9.3966
DSH1 GDSC2 4.4167 6.9245 3.0987 7.4718
HEC-1 GDSC2 4.6806 9.197 2.1765 12.4408
NEC8 GDSC2 4.7604 6.7909 3.4311 4.4865
MS751 GDSC2 4.8296 7.6877 3.0411 6.7436
OV17R GDSC2 4.8817 9.143 2.3606 10.7978
SiSo GDSC2 4.8994 10.802 1.5497 15.4166
HT-3 GDSC2 4.949 8.4216 2.7683 8.1378
TC-YIK GDSC2 4.9922 7.2372 3.378 4.2859
C-4-I GDSC2 5.0226 8.3654 2.8503 7.454
LB831-BLC GDSC2 5.0665 8.2863 2.9208 6.9169
ME-180 GDSC2 5.1087 7.8372 3.1689 5.3029
UWB1.289 GDSC2 5.1199 8.7012 2.7565 7.7965
HeLa GDSC2 5.1549 12.0469 1.1298 16.9242
OVCA433 GDSC2 5.167 7.4369 3.3999 3.7891
SKG-IIIa GDSC2 5.272 11.4851 1.4981 14.7085
HEY GDSC2 5.2764 9.3117 2.5708 8.5526
JAR GDSC2 5.3133 6.9361 3.7193 1.7202
SW954 GDSC2 5.3709 7.3737 3.5562 2.5146
OVCA420 GDSC2 5.4382 8.7832 2.939 5.9821
JHOS-3 GDSC2 5.4682 9.3428 2.6907 7.4005
OVMIU GDSC2 5.5695 10.0297 2.429 8.726
OMC-1 [Human cervical carcinoma] GDSC2 5.5854 8.0397 3.3806 3.1342
SKN GDSC2 5.7489 8.4594 3.2867 3.3839
SiHa GDSC2 5.9063 11.7211 1.8451 11.2948
PEO1 GDSC2 5.9716 9.7769 2.8161 5.6486
Ca Ski GDSC2 5.9935 13.3904 1.0941 15.0108
ACC-OV7 GDSC2 6.1236 12.3785 1.6783 11.7143
BPH-1 GDSC2 6.3811 17.5386 -0.6586 21.4665
PWR-1E GDSC2 6.6062 8.3284 3.7577 0.4154
CAL-39 GDSC2 6.7149 13.7527 1.4209 11.7936
SW962 GDSC2 6.7335 8.3256 3.8068 0.2561
SW756 GDSC2 6.9566 18.7337 -0.8236 20.7752
⏷ Show the Full List of 36 Cancer Drug Sensitivity Data of This Drug

References

1 Deubiquitylating enzymes and drug discovery: emerging opportunities. Nat Rev Drug Discov. 2018 Jan;17(1):57-78.
2 Synthesis and structure-activity relationship studies of N-benzyl-2-phenylpyrimidin-4-amine derivatives as potent USP1/UAF1 deubiquitinase inhibitors with anticancer activity against nonsmall cell lung cancer. J Med Chem. 2014 Oct 9;57(19):8099-110.