Details of the Drug

General Information of Drug (ID: DMY9ZAS)

• Drug Name: EUK-189
• Synonyms: EUK-189 (topical formulation, radiation burns); EUK-189 (topical formulation, radiation burns), Minerva/Proteome; EUK-189 (topicalformulation, radiation burns), Minerva/Tyrian

Indication

Disease Entry	ICD 11	Status	REF
Skin burns	ME65.0	Phase 1	[1]

• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight; 469.4
  Logarithm of the Partition Coefficient; Not Available
  Rotatable Bond Count; 6
  Hydrogen Bond Donor Count; 1
  Hydrogen Bond Acceptor Count; 8
• Chemical Identifiers:
  Formula: C22H26MnN2O6-2
  IUPAC Name: acetic acid;2-ethoxy-6-[2-[(3-ethoxy-2-oxidophenyl)methylideneamino]ethyliminomethyl]phenolate;manganese
  Canonical SMILES: CCOC1=CC=CC(=C1[O-])C=NCCN=CC2=C(C(=CC=C2)OCC)[O-].CC(=O)O.[Mn]
  InChI: InChI=1S/C20H24N2O4.C2H4O2.Mn/c1-3-25-17-9-5-7-15(19(17)23)13-21-11-12-22-14-16-8-6-10-18(20(16)24)26-4-2;1-2(3)4;/h5-10,13-14,23-24H,3-4,11-12H2,1-2H3;1H3,(H,3,4);/p-2
  InChIKey: SZYIPDLZPMRUNA-UHFFFAOYSA-L
• Cross-matching ID:
  PubChem CID: 146157762
  TTD ID: D06VAQ

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Catalase (CAT)	TTPS279	CATA_HUMAN	Modulator	[1]
Superoxide dismutase Cu-Zn (SOD Cu-Zn)	TT6RVLG	SODC_HUMAN	Modulator	[1]

References

• [1] Evaluation of EUK-189, a synthetic superoxide dismutase/catalase mimetic as a radiation countermeasure. Immunopharmacol Immunotoxicol. 2008;30(2):271-90.