Details of the Drug

General Information of Drug (ID: DMYNPK8)

Drug Name
Hexylcarbamoyl fluorouracil
Synonyms Carmofur; HCFU; Yamaful; 1-hexylcarbamoyl-5-fluorouracil
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Withdrawn from market [1]
Coronavirus Disease 2019 (COVID-19) 1D6Y Investigative [2]
ATC Code
L01BC04: Hexylcarbamoyl fluorouracil
L01BC: Pyrimidine analogues
L01B: ANTIMETABOLITES
L01: ANTINEOPLASTIC AGENTS
L: ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
Chemical Identifiers
Formula
C11H16FN3O3
Canonical SMILES
CCCCCCNC(=O)N1C=C(C(=O)NC1=O)F
InChI
InChI=1S/C11H16FN3O3/c1-2-3-4-5-6-13-10(17)15-7-8(12)9(16)14-11(15)18/h7H,2-6H2,1H3,(H,13,17)(H,14,16,18)
InChIKey
AOCCBINRVIKJHY-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
2577
ChEBI ID
CHEMBL460499
CAS Number
61422-45-5
UNII
HA82M3RAB2
DrugBank ID
DB09010
TTD ID
D00IKH
Drug-Molecule Activity Atlas (DMA)NEW Click to Jump to the Detailed DMA Information of This Drug
Drug Pharmacogenomic Perturbation (DPP)NEW Click to Jump to the Detailed DPP Information of This Drug
Drug ADMET Endpoint Profile (DAE)NEW Click to Jump to the Detailed DAE Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
COVID-19 papain-like proteinase (PL-PRO) TTNHMO8 R1AB_SARS2 (819-2763) Inhibitor [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2 Structure of Mpro from COVID-19 virus and discovery of its inhibitors. Nature. 2020 Apr 9.