Details of the Drug

General Information of Drug (ID: DMZA45C)

Drug Name
BX-912
Synonyms BX 912; BX912
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL is unavailable 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 471.4
Logarithm of the Partition Coefficient (xlogp) 2.9
Rotatable Bond Count (rotbonds) 7
Hydrogen Bond Donor Count (hbonddonor) 4
Hydrogen Bond Acceptor Count (hbondacc) 6
Chemical Identifiers
Formula
C20H23BrN8O
IUPAC Name
N-[3-[[5-bromo-4-[2-(1H-imidazol-5-yl)ethylamino]pyrimidin-2-yl]amino]phenyl]pyrrolidine-1-carboxamide
Canonical SMILES
C1CCN(C1)C(=O)NC2=CC=CC(=C2)NC3=NC=C(C(=N3)NCCC4=CN=CN4)Br
InChI
InChI=1S/C20H23BrN8O/c21-17-12-24-19(28-18(17)23-7-6-16-11-22-13-25-16)26-14-4-3-5-15(10-14)27-20(30)29-8-1-2-9-29/h3-5,10-13H,1-2,6-9H2,(H,22,25)(H,27,30)(H2,23,24,26,28)
InChIKey
DMMILYKXNCVKOJ-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
11754511
ChEBI ID
CHEBI:91357
CAS Number
702674-56-4
TTD ID
D0IX7Y
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Checkpoint kinase-1 (CHK1) TTTU902 CHK1_HUMAN Inhibitor [2]
Cyclin-dependent kinase 2 (CDK2) TT7HF4W CDK2_HUMAN Inhibitor [2]
Fungal Protein kinase A (Fung ypkA) TTYVI76 Q56921_YEREN Inhibitor [2]
Glycogen synthase kinase-3 beta (GSK-3B) TTRSMW9 GSK3B_HUMAN Inhibitor [2]
Phosphoinositide dependent protein kinase-1 (PDPK1) TT9QBI6 PDPK1_HUMAN Inhibitor [2]
Vascular endothelial growth factor receptor 2 (KDR) TTUTJGQ VGFR2_HUMAN Inhibitor [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Glycogen synthase kinase-3 beta (GSK-3B) DTT GSK3B 1.26E-01 -0.23 -0.77
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1 3.2558 4.5782 2.6596 5.8684
ES8 GDSC1 -2.9199 -1.7348 -2.9199 78.1806
EW-18 GDSC1 -1.7144 2.4687 -1.9629 60.3576
ES7 GDSC1 -1.4491 2.6032 -1.7033 57.954
ES5 GDSC1 -1.0381 5.5619 -2.1813 52.8666
MHH-ES-1 GDSC1 -0.7968 7.0399 -2.5268 50.9723
G-292 clone A141B1 GDSC1 0.0596 3.5077 -0.2839 42.5153
ES1 GDSC1 0.1237 7.6603 -1.8529 44.9788
TC-71 GDSC1 0.5957 4.7526 -0.1266 38.0101
EW-1 GDSC1 0.6268 5.9881 -0.6003 39.4119
SK-ES-1 GDSC1 1.1604 6.4312 -0.2506 34.9886
H-EMC-SS GDSC1 1.3285 7.2951 -0.482 34.9442
EW-7 GDSC1 1.3594 6.251 0.0315 32.6623
SK-PN-DW GDSC1 1.4135 5.5229 0.4125 30.4675
HuO9 GDSC1 1.5951 6.6968 0.0602 31.2518
EW-13 GDSC1 1.6457 6.3402 0.2764 29.9158
NY GDSC1 1.7895 6.0149 0.5699 27.562
NOS-1 [Human HNSCC] GDSC1 1.9011 6.8688 0.2772 28.6003
EW-11 GDSC1 2.1984 7.3834 0.3116 26.9804
ES6 GDSC1 2.3457 7.5581 0.3633 26.0188
CHSA0011 GDSC1 2.382 7.593 0.3797 25.7634
CAL-78 GDSC1 2.5872 5.038 1.812 15.2612
ES4 GDSC1 2.6726 8.7766 0.0572 26.1957
CHSA8926 GDSC1 2.7593 8.0096 0.515 23.348
CHSA0108 GDSC1 2.7641 5.0918 1.9562 13.3779
HuO-3N1 GDSC1 2.9027 8.8162 0.2396 24.2939
A-673 GDSC1 3.187 7.8092 0.9872 18.677
EW-3 GDSC1 3.6636 9.464 0.5545 19.6183
SJSA-1 GDSC1 3.6903 5.2685 2.6621 4.3757
CADO-ES1 GDSC1 3.8192 5.596 2.5947 4.5208
EW-16 GDSC1 4.392 11.7601 -0.0169 20.3376
HOS GDSC1 4.7474 6.3226 2.8095 1.2027
EW-24 GDSC1 5.0108 6.2471 2.9515 0.3619
U2OS GDSC1 5.4316 8.6746 2.1625 4.0239
MG-63 GDSC1 5.8055 7.0557 2.9579 0.0954
CAL-72 GDSC1 5.979 7.4028 2.9013 0.1403
SaOS-2 GDSC1 6.0501 7.5631 2.872 0.1704
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 146 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC1 0.2183 3.654 -0.154 40.8351
MOLM-13 GDSC1 -6.1434 -4.0637 -6.1435 97.7932
MV4-11 GDSC1 -5.7998 -3.0761 -5.8013 94.8673
ALL-PO GDSC1 -5.281 -1.3429 -5.3097 88.2809
EoL-1 GDSC1 -4.2847 5.0719 -5.507 68.9978
Mono-Mac-6 GDSC1 -4.1997 2.3427 -4.6368 74.1539
ALL-SIL GDSC1 -3.9677 -2.3868 -3.9678 88.5821
NKM-1 GDSC1 -3.6313 -0.1711 -3.6681 79.2581
Loucy GDSC1 -3.597 -1.1845 -3.6009 82.4644
ATN-1 GDSC1 -3.381 4.1723 -4.2344 67.2651
Kasumi-1 GDSC1 -3.1471 0.9646 -3.2595 73.3217
RS4;11 GDSC1 -3.1155 -1.6208 -3.1156 80.0416
MOLP-8 GDSC1 -2.6245 0.7921 -2.6896 70.4791
P12-Ichikawa GDSC1 -2.6173 -0.872 -2.6182 73.9282
RPMI-8402 GDSC1 -2.3573 0.7959 -2.4099 68.4309
Karpas-45 GDSC1 -2.3157 1.9353 -2.5117 65.8056
SU-DHL-5 GDSC1 -2.2931 -1.5661 -2.2931 70.6126
PF-382 GDSC1 -2.2482 0.7449 -2.292 67.6236
OCI-Ly19 GDSC1 -2.2336 0.0702 -2.2437 68.6809
BV-173 GDSC1 -2.2065 -0.7703 -2.2067 69.3402
CCRF-CEM GDSC1 -1.9138 -0.6238 -1.9139 65.805
NALM-6 GDSC1 -1.8795 0.7163 -1.9073 64.2619
SU-DHL-10 GDSC1 -1.8708 -0.9407 -1.8708 65.3294
KE-37 GDSC1 -1.858 2.117 -2.0501 62.0162
GDM-1 GDSC1 -1.7498 1.5907 -1.8521 61.8344
BE-13 GDSC1 -1.7308 2.2961 -1.946 60.7178
BL-41 GDSC1 -1.7162 1.5958 -1.8169 61.5198
KOPN-8 GDSC1 -1.684 0.9263 -1.7177 62.0326
ST486 GDSC1 -1.6093 2.0597 -1.7718 59.9663
OCI-AML-5 GDSC1 -1.5303 2.8819 -1.8549 58.3625
697 GDSC1 -1.4658 0.1131 -1.4676 60.1786
SR GDSC1 -1.4545 2.4456 -1.6762 58.1573
NU-DUL-1 GDSC1 -1.4028 2.0089 -1.5413 58.1026
NB4 GDSC1 -1.345 3.4982 -1.8138 56.283
P30/OHK GDSC1 -1.2983 0.7964 -1.3126 57.9188
OCI-M1 GDSC1 -1.2693 1.8186 -1.3702 56.9363
SIG-M5 GDSC1 -1.2649 1.4925 -1.3265 57.1247
SUP-B15 GDSC1 -1.2046 3.5029 -1.6619 55.1184
DND-41 GDSC1 -1.1559 2.8445 -1.4383 55.1079
SU-DHL-6 GDSC1 -1.0429 1.1329 -1.0659 54.8109
SUP-M2 GDSC1 -0.9835 5.839 -2.2309 52.4089
MY-M12 GDSC1 -0.7589 5.059 -1.6924 50.9175
EB2 GDSC1 -0.6159 4.8239 -1.4525 49.7661
SU-DHL-16 GDSC1 -0.3987 3.6932 -0.8384 47.5778
MOLT-13 GDSC1 -0.3472 1.3446 -0.3596 46.3336
QIMR-WIL GDSC1 -0.3401 5.0622 -1.2448 47.4524
MOLT-16 GDSC1 -0.2514 3.6043 -0.6514 46.0112
P32/ISH GDSC1 -0.2436 2.3609 -0.3523 45.3343
ML-2 GDSC1 -0.191 5.5502 -1.2757 46.358
Karpas-620 GDSC1 0.0042 4.0623 -0.5166 43.5902
BC-1 GDSC1 0.0154 3.8668 -0.4409 43.3122
OPM-2 GDSC1 0.0436 2.559 -0.0766 41.9415
MOLT-4 GDSC1 0.2014 4.3643 -0.4065 41.7692
SUP-T1 GDSC1 0.2251 6.7596 -1.3493 43.6577
MC116 GDSC1 0.3319 1.6013 0.3257 37.8405
Ku812 GDSC1 0.3534 7.2331 -1.4283 43.0092
HL-60 GDSC1 0.4589 3.2772 0.2155 37.5113
Sc-1 GDSC1 0.4743 6.3133 -0.8983 41.1785
Reh GDSC1 0.5005 4.5053 -0.1353 38.6982
JSC-1 GDSC1 0.6029 8.4907 -1.7555 42.1755
VAL GDSC1 0.6972 4.4193 0.1077 36.3539
SU-DHL-8 GDSC1 0.7331 11.7593 -3.1911 43.5166
Daudi GDSC1 0.8002 4.5144 0.1827 35.3317
CA46 GDSC1 0.86 6.436 -0.5571 37.8463
CTV-1 GDSC1 0.8735 5.0966 0.0316 35.5421
WIL2 NS GDSC1 0.9054 6.1434 -0.3811 36.9739
SUP-HD1 GDSC1 0.9253 6.2184 -0.3939 36.9003
LC4-1 GDSC1 0.9777 7.0108 -0.6982 37.6125
PL-21 GDSC1 1.0711 6.3239 -0.2926 35.6668
Ramos.2G6.4C10 GDSC1 1.1386 7.3945 -0.7155 36.7734
HH [Human lymphoma] GDSC1 1.2793 6.1841 -0.0189 33.3387
TUR GDSC1 1.2845 10.319 -1.9732 39.2765
EM-2 GDSC1 1.3226 8.5002 -1.0591 36.8647
CESS GDSC1 1.4005 7.6006 -0.5555 34.8323
OCI-AML-2 GDSC1 1.4497 4.2942 0.961 27.0265
Namalwa GDSC1 1.4628 7.2228 -0.3164 33.5945
BALL-1 GDSC1 1.4968 5.3237 0.5853 29.0445
NOMO-1 GDSC1 1.499 10.3344 -1.7801 37.9025
MLMA GDSC1 1.5792 7.1276 -0.1578 32.3226
H9 GDSC1 1.5914 7.6302 -0.3847 33.2016
Farage GDSC1 1.6317 5.6007 0.6004 28.2196
RPMI-6666 GDSC1 1.725 8.2089 -0.5349 33.1211
ARH-77 GDSC1 1.7861 6.4071 0.3838 28.6173
JJN-3 GDSC1 1.7973 3.982 1.4507 21.8203
JURL-MK1 GDSC1 1.8008 4.4825 1.2586 23.1262
VL51 GDSC1 1.8856 7.6852 -0.1295 30.6545
KCL-22 GDSC1 1.9247 7.494 -0.0002 29.8659
SU-DHL-4 GDSC1 1.9538 3.7243 1.7115 19.1545
A3/Kawakami GDSC1 1.987 6.4471 0.561 26.6115
Hs 445 GDSC1 2.0117 9.4158 -0.856 32.9592
KG-1 GDSC1 2.0689 7.9181 -0.0699 29.5026
WSU-DLCL2 GDSC1 2.3067 7.7468 0.2348 26.8867
DEL GDSC1 2.3414 8.6267 -0.1662 28.7037
A4/Fukuda GDSC1 2.3849 6.0483 1.1344 21.083
RL GDSC1 2.4166 6.7874 0.806 23.0897
Karpas-422 GDSC1 2.4687 8.4942 0.0147 27.2823
BC-3 GDSC1 2.5207 9.9373 -0.6542 30.0181
WSU-NHL GDSC1 2.6405 5.5035 1.6402 16.3085
KMS-12-BM GDSC1 2.6853 10.2875 -0.6833 29.4634
NK-92MI GDSC1 2.6974 5.2237 1.8293 14.6362
KMOE-2 GDSC1 2.7023 7.7935 0.5715 23.2585
AMO1 GDSC1 2.7347 7.9424 0.5266 23.3842
LAMA-84 GDSC1 2.736 6.4716 1.2556 18.6827
JVM-2 GDSC1 2.834 5.2601 1.9404 13.1969
THP-1 GDSC1 2.8398 6.1829 1.4923 16.5439
GR-ST GDSC1 2.8617 7.8239 0.6979 21.8277
L-363 GDSC1 2.8677 4.2441 2.46 9.0605
K-562 GDSC1 2.9086 7.0233 1.1374 18.7785
YT GDSC1 2.9782 8.083 0.6708 21.5156
HDLM-2 GDSC1 3.0067 4.8295 2.3112 9.5992
MEG-01 GDSC1 3.0575 6.9804 1.2895 17.1166
OCI-AML-3 GDSC1 3.1253 9.5149 0.0823 24.2374
EJM GDSC1 3.1968 5.9488 1.9248 11.8495
SU-DHL-1 GDSC1 3.1979 3.7764 3.003 3.4166
U-698-M GDSC1 3.232 4.466 2.6946 5.6852
RPMI-8226 GDSC1 3.345 4.7897 2.6301 5.767
KM-H2 GDSC1 3.3566 4.5127 2.7783 4.5557
KMS-11 GDSC1 3.3649 4.5841 2.7495 4.7528
LP-1 GDSC1 3.388 4.986 2.5676 6.1046
DB GDSC1 3.4467 7.4381 1.3902 14.9174
HEL GDSC1 3.4517 4.8356 2.6944 4.8829
HT GDSC1 3.4663 4.5469 2.8499 3.611
KY821 GDSC1 3.5241 4.8414 2.7484 4.2182
SCC-3 GDSC1 3.6235 6.4199 2.041 9.4197
Granta-519 GDSC1 3.7128 12.0055 -0.675 25.6326
MHH-PREB-1 GDSC1 3.7144 5.167 2.7291 3.7886
Karpas-299 GDSC1 3.7193 7.0376 1.8086 10.8773
P31/FUJ GDSC1 3.8608 5.1382 2.8424 2.5467
HAL-01 GDSC1 3.8937 8.3318 1.3008 13.9983
JVM-3 GDSC1 3.9132 6.8391 2.0543 8.3904
CTB-1 GDSC1 3.9276 10.7131 0.1424 21.0172
TK [Human B-cell lymphoma] GDSC1 3.9947 7.3719 1.8524 9.6683
SK-MM-2 GDSC1 4.0446 8.7987 1.1852 14.3014
RPMI-8866 GDSC1 4.1564 5.8839 2.6806 3.0318
L-1236 GDSC1 4.1569 7.8066 1.7578 9.8815
L-540 GDSC1 4.2243 7.4079 2.0002 7.8892
DG-75 GDSC1 4.2804 8.4543 1.5303 11.1628
MN-60 GDSC1 4.5206 11.3329 0.2918 18.2985
L-428 GDSC1 4.5583 6.5378 2.6202 2.632
Jiyoye GDSC1 4.6913 6.4565 2.7264 1.7449
ROS-50 GDSC1 5.0158 11.2404 0.6969 14.5194
ME1 GDSC1 5.212 7.2009 2.6723 1.3696
U266B1 GDSC1 5.5115 7.2861 2.7688 0.677
Raji GDSC1 5.6081 6.9045 2.9407 0.1605
RC-K8 GDSC1 5.7014 6.9977 2.9417 0.1372
HC-1 GDSC1 5.8807 17.1839 -1.5833 22.8928
⏷ Show the Full List of 146 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OACM5.1 C GDSC1 0.0557 7.2855 -1.7545 45.2678
OACP4 C GDSC1 0.9937 4.492 0.3982 33.0299
KYSE-50 GDSC1 1.9854 6.9513 0.3188 27.9635
ESO-26 GDSC1 2.4468 6.1662 1.1363 20.7861
TE-12 GDSC1 2.663 6.6601 1.0961 20.0983
FLO-1 GDSC1 3.2787 8.8278 0.5555 21.028
KYSE-220 GDSC1 3.401 8.8981 0.6225 20.167
SK-GT-4 GDSC1 3.7292 6.6021 2.0326 9.1362
HCE-4 GDSC1 3.8308 5.5534 2.6236 4.268
ESO-51 GDSC1 3.9891 6.2904 2.3771 5.7044
KYAE-1 GDSC1 4.6368 8.6621 1.6797 9.0957
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1 3.6649 15.57 -2.4954 31.8098
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IMR-5 GDSC1 -2.7703 -1.1718 -2.7706 75.915
MHH-NB-11 GDSC1 0.0228 2.8678 -0.1609 42.4214
KP-N-YS GDSC1 0.5147 3.5267 0.207 37.1551
CHP-134 GDSC1 0.5642 9.1715 -2.113 42.9405
GI-ME-N GDSC1 0.8251 6.1319 -0.4583 37.7283
NB69 GDSC1 1.2553 4.7525 0.5739 30.4886
CHP-212 GDSC1 1.3767 10.3029 -1.8789 38.6663
SK-N-MC-IXC GDSC1 1.7035 5.8617 0.5545 28.1
SJNB-7 GDSC1 1.9034 7.8053 -0.1708 30.7529
NH-12 GDSC1 1.9051 5.4813 0.9304 24.7683
TGW GDSC1 2.3805 5.8837 1.2093 20.5885
SJNB-6 GDSC1 2.8621 5.7293 1.7363 14.6327
Kelly GDSC1 3.2046 4.4171 2.6946 5.7931
SK-N-BE(2)-M17 GDSC1 3.3616 6.9451 1.5662 13.9471
SK-N-FI GDSC1 3.434 9.6367 0.2805 22.0137
SK-N-DZ GDSC1 3.4435 5.251 2.4805 6.5953
SK-N-SH GDSC1 3.5603 9.6426 0.3814 20.9898
SJNB-14 GDSC1 3.5855 6.8747 1.7842 11.5151
SiMa GDSC1 3.6653 5.7714 2.3955 6.5259
SJNB-13 GDSC1 3.7624 5.8699 2.4196 6.0369
NB(TU)1 GDSC1 3.8419 7.0979 1.873 9.9914
SJNB-12 GDSC1 3.8846 9.1169 0.9035 16.6952
SJNB-10 GDSC1 3.9508 6.8698 2.0669 8.1804
SJNB-5 GDSC1 4.0053 8.7191 1.1946 14.3647
LA-N-6 GDSC1 4.0309 7.2774 1.9255 9.0097
SK-N-AS GDSC1 4.4223 9.7243 1.011 14.2782
KP-N-YN GDSC1 4.7711 7.072 2.5028 3.0128
GOTO GDSC1 4.9396 9.0408 1.7003 8.1775
SJNB-17 GDSC1 5.2142 9.235 1.7831 6.9675
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC1 3.4202 6.3333 1.9206 11.0535
Cancer Drug Sensitivity Data Curated from 51 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MDA-MB-468 GDSC1 -0.3282 1.741 -0.3651 46.1675
HCC1187 GDSC1 0.1854 4.8661 -0.6083 42.4289
HCC70 GDSC1 1.8526 7.3425 0.004 30.2006
DU4475 GDSC1 1.9549 4.2305 1.5233 20.4698
BT-549 GDSC1 1.9885 5.7579 0.8864 24.6273
OCUB-M GDSC1 2.2463 9.5312 -0.6989 31.354
MCF-7 GDSC1 2.8029 6.5028 1.301 18.0787
CAL-85-1 GDSC1 2.8129 4.6123 2.2329 11.043
HCC1569 GDSC1 3.1811 7.4224 1.1753 17.4287
HCC1599 GDSC1 3.3366 11.9609 -0.9625 28.0942
Hs 578T GDSC1 3.4115 6.6237 1.7683 12.2498
AU565 GDSC1 3.5558 4.8813 2.7529 4.0822
HCC202 GDSC1 3.5583 5.9443 2.2265 8.1967
CAL-120 GDSC1 3.6282 9.2868 0.6144 19.3866
MDA-MB-157 GDSC1 3.7022 7.2935 1.6679 11.9892
UACC-893 GDSC1 3.7199 5.2925 2.6718 4.2135
BT-474 GDSC1 3.7448 5.1535 2.7571 3.4884
HCC1806 GDSC1 3.7454 6.5832 2.0544 8.9161
COLO 824 GDSC1 3.9327 10.3045 0.35 19.8653
HDQ-P1 GDSC1 3.9405 6.4251 2.2772 6.6048
MDA-MB-453 GDSC1 3.9791 9.0045 1.0328 15.5361
CAL-51 GDSC1 4.1994 14.3891 -1.4743 27.1216
JIMT-1 GDSC1 4.2673 5.9976 2.6953 2.6913
ZR-75-30 GDSC1 4.2696 8.5815 1.4601 11.6929
Evsa-T GDSC1 4.3524 6.0955 2.7006 2.4852
HCC1428 GDSC1 4.3657 5.9273 2.7825 1.9221
MDA-MB-330 GDSC1 4.5081 8.0665 1.878 8.0158
MFM-223 GDSC1 4.5646 10.9974 0.4899 17.0453
HCC1395 GDSC1 4.5776 8.0485 1.9332 7.4353
MDA-MB-175-VII GDSC1 4.6324 6.4109 2.7155 1.9006
HCC1937 GDSC1 4.9013 9.9787 1.2273 11.4893
HCC38 GDSC1 4.9265 8.5561 1.9193 6.6849
BT-20 GDSC1 4.9418 10.103 1.1952 11.5917
HCC2157 GDSC1 5.0567 7.4528 2.4912 2.5997
CAMA-1 GDSC1 5.1699 9.3423 1.7058 7.5922
HCC1419 GDSC1 5.2319 6.6595 2.8879 0.4406
MDA-MB-436 GDSC1 5.4016 7.1301 2.7822 0.7045
UACC-812 GDSC1 5.4206 7.164 2.7773 0.7093
T-47D GDSC1 5.4565 9.7703 1.6844 7.0962
MRK-nu-1 GDSC1 5.4631 6.7663 2.9366 0.2095
CAL-148 GDSC1 5.4984 7.344 2.7418 0.7889
MDA-MB-231 GDSC1 5.5139 11.7569 0.7894 12.6518
MDA-MB-415 GDSC1 5.5171 10.3316 1.4626 8.4182
EFM-192A GDSC1 5.7334 7.3576 2.8291 0.3635
HCC2218 GDSC1 5.7372 7.8666 2.6438 0.9957
HCC1500 GDSC1 5.7619 7.2895 2.8634 0.2688
HCC1954 GDSC1 5.874 7.8006 2.7239 0.6034
BT-483 GDSC1 6.0234 7.3471 2.935 0.0894
EFM-19 GDSC1 6.0646 16.7041 -1.2175 21.0726
MDA-MB-361 GDSC1 6.1147 8.0428 2.7292 0.4631
YMB-1-E GDSC1 6.4334 9.0562 2.4843 1.0905
⏷ Show the Full List of 51 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 54 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DK-MG GDSC1 0.7126 6.8181 -0.8778 39.6699
MOG-G-UVW GDSC1 0.7428 6.6014 -0.7501 39.1364
GI-1 GDSC1 1.7341 6.1794 0.4386 28.5884
GaMG GDSC1 1.8343 6.1054 0.5721 27.318
D-247MG GDSC1 1.9422 6.0628 0.6985 26.0237
D-392MG GDSC1 2.0701 11.6068 -1.8845 35.7647
SK-MG-1 GDSC1 2.0957 5.6171 1.0579 22.9776
KS-1 [Human Krukenberg tumour] GDSC1 2.1334 7.5351 0.177 27.9911
D-423MG GDSC1 2.199 6.0326 0.9634 23.0991
D-336MG GDSC1 2.2022 8.2401 -0.1035 29.0405
CAS-1 GDSC1 2.2334 7.787 0.1473 27.6756
D-566MG GDSC1 2.2413 4.3091 1.7921 17.0669
YH-13 GDSC1 2.263 7.1447 0.4884 25.7008
A-172 GDSC1 2.7372 7.4383 0.7788 21.8491
42-MG-BA GDSC1 2.7609 9.041 0.0036 26.0952
SF539 GDSC1 2.796 8.7399 0.1843 25.0254
Hs 683 GDSC1 2.8237 4.5394 2.278 10.6498
D-263MG GDSC1 2.8872 3.4148 2.8272 6.2602
M059J GDSC1 2.9202 4.0417 2.6058 7.7117
8-MG-BA GDSC1 3.0957 5.2238 2.1973 10.1249
H4 GDSC1 3.2072 4.6634 2.5746 6.7255
NMC-G1 GDSC1 3.2312 5.8522 2.0025 11.1163
MOG-G-CCM GDSC1 3.3327 8.7915 0.6189 20.4446
SF126 GDSC1 3.3498 4.9067 2.5756 6.1784
AM-38 GDSC1 3.4328 8.9045 0.6456 19.9095
SW1088 GDSC1 3.4816 5.3844 2.4446 6.7467
LN-18 GDSC1 3.5632 4.6438 2.8757 3.1019
Becker GDSC1 3.6715 10.6539 -0.0334 22.8116
SW1783 GDSC1 3.7572 6.3807 2.1637 8.0354
KNS-81-FD GDSC1 3.8152 6.5231 2.1371 8.0581
U-251MG GDSC1 3.8597 15.1779 -2.1405 30.2578
SF268 GDSC1 3.8825 9.2877 0.8168 17.2539
T98G GDSC1 3.9068 5.6537 2.6275 4.0314
Onda 11 GDSC1 3.9747 7.5418 1.7537 10.4666
SF295 GDSC1 3.977 5.7866 2.6113 3.9698
GB-1 GDSC1 4.0207 7.1376 1.9866 8.5797
D-502MG GDSC1 4.0711 8.3888 1.408 12.6721
LNZTA3WT4 GDSC1 4.1231 6.3955 2.4183 5.034
PFSK-1 GDSC1 4.1326 6.7639 2.2479 6.2862
SNB-75 GDSC1 4.1771 8.8139 1.2776 13.2484
KINGS-1 GDSC1 4.2746 8.7313 1.3903 12.1675
LN-405 GDSC1 4.3568 8.5028 1.5616 10.7156
ONS-76 GDSC1 4.4914 12.5438 -0.3293 21.5656
Onda 10 GDSC1 4.6037 8.1946 1.881 7.7449
Daoy GDSC1 4.8172 10.9465 0.699 15.066
U-87MG ATCC GDSC1 5.0925 10.5112 1.1018 11.7981
D-542MG GDSC1 5.1708 6.6553 2.8652 0.5569
LN-229 GDSC1 5.3832 6.9368 2.8462 0.4889
YKG-1 GDSC1 5.3962 12.8066 0.2042 16.2757
U-118MG GDSC1 5.4691 7.5857 2.6361 1.2731
D283 Med GDSC1 5.5108 7.0589 2.8514 0.4043
DBTRG-05MG GDSC1 5.5365 10.9707 1.1764 10.2122
KNS-42 GDSC1 6.0669 11.386 1.3122 8.1864
KALS-1 GDSC1 6.7805 15.691 -0.2442 15.1813
⏷ Show the Full List of 54 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ETK-1 GDSC1 4.6467 8.1719 1.9202 7.3536
TGBC24TKB GDSC1 5.418 15.9209 -1.3017 23.0387
TGBC1TKB GDSC1 5.6782 7.2596 2.8431 0.3503
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MFE-280 GDSC1 1.3159 6.672 -0.2048 33.9317
ESS-1 GDSC1 3.1801 5.602 2.0833 10.6836
EN GDSC1 3.3756 10.1081 -0.0036 23.7282
MFE-319 GDSC1 3.6056 6.4607 2.0065 9.7458
MFE-296 GDSC1 3.8783 5.9799 2.4499 5.4618
AN3-CA GDSC1 3.9652 9.7901 0.6316 18.1175
KLE GDSC1 4.5706 8.8194 1.5585 10.1312
RL95-2 GDSC1 5.6006 7.1794 2.8424 0.3867
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SN12C GDSC1 2.5172 6.1607 1.2053 19.9928
RXF 393L GDSC1 2.6143 5.1965 1.7628 15.5081
KTCTL-140 GDSC1 2.685 5.3321 1.7652 15.1756
LB1047-RCC GDSC1 2.6912 6.6517 1.126 19.7724
786-O GDSC1 2.7518 5.8018 1.5992 16.1286
KTCTL-21 GDSC1 2.9879 7.9524 0.7444 21.0236
BFTC-909 GDSC1 3.1992 6.5394 1.6319 14.0691
VMRC-RCZ GDSC1 3.2253 6.3877 1.73 13.2309
HA7-RCC GDSC1 3.362 5.4862 2.296 8.3365
KTCTL-195 GDSC1 3.4451 10.5494 -0.1666 24.279
ACHN GDSC1 3.4735 6.8182 1.7219 12.3783
UO-31 GDSC1 3.5886 5.6836 2.38 6.8947
CAL-54 GDSC1 3.5999 7.3764 1.5454 13.2458
A-704 GDSC1 3.6065 6.4371 2.019 9.6468
769-P GDSC1 3.6721 6.073 2.2512 7.6279
LB996-RCC GDSC1 3.8288 6.179 2.3166 6.6326
TK-10 GDSC1 3.9245 6.9347 2.0156 8.6507
OS-RC-2 GDSC1 3.9365 7.3166 1.8363 9.9692
NCC021 GDSC1 4.0896 5.9768 2.5951 3.8076
BB65-RCC GDSC1 4.2014 9.6691 0.8734 15.8477
SW156 GDSC1 4.2575 6.8926 2.2709 5.7834
KTCTL-26A GDSC1 4.3253 7.5624 1.9957 7.6441
KTCTL-13 GDSC1 4.3984 7.1328 2.2498 5.5832
KTCTL-1M GDSC1 4.4227 10.2335 0.7608 15.8599
A-498 GDSC1 4.4534 6.4973 2.5783 3.1164
KMRC-20 GDSC1 4.5234 7.9884 1.9257 7.6301
SW13 GDSC1 4.6155 6.826 2.5244 3.1619
Caki-1 GDSC1 4.9423 8.9835 1.7291 7.9715
RCC10RGB GDSC1 5.2333 6.4217 2.9729 0.2071
LB2241-RCC GDSC1 5.2554 7.728 2.4766 2.3849
VMRC-RCW GDSC1 5.3168 7.453 2.6196 1.5182
KMRC-1 GDSC1 5.552 11.5252 0.9247 11.74
⏷ Show the Full List of 32 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 44 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H716 GDSC1 0.0716 3.9837 -0.4174 42.8006
SW48 GDSC1 0.3112 3.7959 -0.0966 39.9211
KM12 GDSC1 0.6481 5.4769 -0.3617 38.5132
SNU-175 GDSC1 0.9272 4.5491 0.3054 33.922
COLO205 GDSC1 1.6288 5.1969 0.7763 27.189
SW620 GDSC1 1.9204 6.1004 0.6594 26.3679
HCT 116 GDSC1 2.0753 9.1518 -0.6679 31.9898
NCI-H747 GDSC1 2.2689 5.1426 1.4496 19.4181
RKO GDSC1 2.5998 8.186 0.2851 25.3173
CW-2 GDSC1 2.6394 7.2573 0.7802 22.2605
GP5d GDSC1 3.2397 4.2477 2.81 4.7483
HCC2998 GDSC1 3.3146 5.7597 2.1196 9.8929
LS411N GDSC1 3.3895 6.1906 1.9667 10.8088
HT-29 GDSC1 3.5166 5.641 2.3445 7.4133
SW948 GDSC1 3.5766 7.8812 1.2746 15.2697
LS513 GDSC1 3.7968 6.791 1.9908 9.2394
LS123 GDSC1 3.839 12.1115 -0.6259 24.9974
SNU-61 GDSC1 3.8396 6.2348 2.2971 6.7503
LS1034 GDSC1 3.8764 5.9062 2.4843 5.2036
T84 GDSC1 3.9616 7.6888 1.6714 11.1171
SNU-C1 GDSC1 4.0631 7.1225 2.0247 8.1672
SNU-407 GDSC1 4.2138 7.9928 1.7079 10.079
SW837 GDSC1 4.3693 8.9825 1.3361 12.2599
SNU-81 GDSC1 4.38 6.8225 2.3838 4.6525
LS180 GDSC1 4.4668 10.3989 0.7121 16.0233
SNU-C5 GDSC1 4.5137 7.9453 1.9399 7.5522
SW1116 GDSC1 4.6023 6.5425 2.6425 2.4082
SW626 GDSC1 4.6728 6.7861 2.5743 2.724
SNU-C2B GDSC1 4.7022 7.1857 2.4128 3.7461
SW1463 GDSC1 4.7946 6.5387 2.7436 1.5007
MDST8 GDSC1 4.8416 10.6536 0.859 14.0174
SW1417 GDSC1 4.8876 7.023 2.5869 2.2833
CaR-1 GDSC1 4.9019 10.787 0.8368 13.9853
COLO 320HSR GDSC1 4.9021 9.7963 1.3155 10.9004
RCM-1 [Human ESC] GDSC1 4.9506 6.7429 2.7349 1.3503
HT115 GDSC1 5.0738 6.4189 2.9136 0.4491
C2BBe1 GDSC1 5.1089 7.5896 2.46 2.7077
CL-11 GDSC1 5.179 7.3959 2.5772 1.9168
CCK-81 GDSC1 5.2122 7.4771 2.5599 1.9689
HCT 15 GDSC1 5.4186 7.0076 2.8343 0.5074
HT-55 GDSC1 5.6345 6.9641 2.9297 0.1732
COLO 678 GDSC1 5.7865 7.4623 2.8119 0.386
LoVo GDSC1 6.6273 8.6347 2.7102 0.3138
SNU-1040 GDSC1 8.0021 24.5385 -3.6575 24.5095
⏷ Show the Full List of 44 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1 4.0797 7.5744 1.8154 9.6863
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-387 GDSC1 -0.2226 2.6254 -0.377 45.2016
SNU-423 GDSC1 1.6629 4.7613 0.9984 25.6032
JHH-7 GDSC1 2.1986 7.1352 0.4325 26.3175
Huh-7 GDSC1 2.8048 4.1301 2.4497 9.4331
JHH-1 GDSC1 3.1611 7.4429 1.148 17.6944
JHH-6 GDSC1 3.4424 4.2158 2.9959 2.5438
JHH-2 GDSC1 3.449 5.4555 2.3828 7.345
Hep 3B2.1-7 GDSC1 3.7912 6.2898 2.2342 7.3838
HLE GDSC1 3.8136 8.4614 1.174 15.1427
SK-HEP-1 GDSC1 3.9255 5.9171 2.5135 4.8437
SNU-475 GDSC1 4.1632 6.8278 2.2382 6.2767
JHH-4 GDSC1 4.3654 6.4791 2.5341 3.61
SNU-398 GDSC1 4.9142 15.3463 -1.3952 24.7542
HuH-1 GDSC1 5.2851 6.7145 2.8887 0.4088
Hep-G2/C3A GDSC1 5.3149 6.718 2.8988 0.3632
SNU-449 GDSC1 6.0637 7.6881 2.8343 0.2342
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 172 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H2227 GDSC1 -3.4817 -1.5914 -3.4823 82.9999
NCI-H2171 GDSC1 -1.006 1.0013 -1.0213 54.4119
LK-2 GDSC1 -0.5399 3.1664 -0.8454 48.9221
COR-L311 GDSC1 -0.2821 6.0027 -1.5551 47.2718
IST-SL1 GDSC1 -0.2794 7.0711 -2.0042 47.5618
NCI-H2731 GDSC1 -0.2086 3.1367 -0.4766 45.3014
NCI-H524 GDSC1 -0.1343 1.9493 -0.1809 43.8241
EPLC-272H GDSC1 -0.1158 7.4977 -2.0237 46.5685
NCI-H847 GDSC1 -0.1123 2.3897 -0.2157 43.7528
NCI-H810 GDSC1 0.2572 9.4553 -2.547 45.0094
NCI-H2081 GDSC1 0.3859 5.7978 -0.7699 41.4355
NCI-H1703 GDSC1 0.5298 6.4235 -0.8893 40.8088
COR-L321 GDSC1 0.5685 8.9877 -2.0221 42.784
LCLC-97TM1 GDSC1 0.6804 8.4556 -1.6627 41.6004
NCI-H2795 GDSC1 0.7693 4.2494 0.2471 35.2285
LB647-SCLC GDSC1 0.9559 6.9294 -0.6828 37.688
SBC-3 GDSC1 1.0407 5.4646 0.0529 34.4137
EMC-BAC-1 GDSC1 1.0582 6.6556 -0.4553 36.3422
Lu-134-A GDSC1 1.0753 4.6741 0.4146 32.4391
NCI-H647 GDSC1 1.1252 4.5891 0.5011 31.6702
NCI-H1048 GDSC1 1.3029 6.1412 0.0243 33.0118
Lu-99A GDSC1 1.3195 6.0223 0.0946 32.5935
NCI-H1304 GDSC1 1.4199 10.7232 -2.0436 38.8247
LXF 289 GDSC1 1.5031 6.0592 0.2633 30.7497
NCI-H1694 GDSC1 1.5164 6.7 -0.0188 32.0357
NCI-H446 GDSC1 1.5448 5.5829 0.5201 29.1484
A-427 GDSC1 1.6151 9.711 -1.3677 36.3426
NCI-H211 GDSC1 1.6923 6.7514 0.13 30.4074
NCI-H209 GDSC1 1.7986 8.5873 -0.6488 33.1944
LC-2/ad GDSC1 1.9412 8.855 -0.6462 32.5178
IST-SL2 GDSC1 1.9661 6.8991 0.3253 28.0237
NCI-H196 GDSC1 2.0269 5.9259 0.8459 24.6921
EMC-BAC-2 GDSC1 2.0871 5.7651 0.9803 23.5319
NCI-H2869 GDSC1 2.1596 6.6672 0.6218 25.4147
NCI-H358 GDSC1 2.2575 8.7602 -0.3084 29.7139
NCI-H1755 GDSC1 2.4472 7.1471 0.6585 23.8586
NCI-H82 GDSC1 2.4663 10.035 -0.751 30.6197
HARA [Human squamous cell lung carcinoma] GDSC1 2.5394 7.684 0.4789 24.5032
NCI-H2722 GDSC1 2.549 4.3205 2.1048 13.2418
NCI-H526 GDSC1 2.6232 8.3085 0.2454 25.4298
EBC-1 GDSC1 2.6253 8.5125 0.1462 25.942
PC-14 GDSC1 2.6258 5.4659 1.6444 16.3421
ABC-1 GDSC1 2.6544 13.071 -2.0977 34.1077
SW1271 GDSC1 2.6741 6.6989 1.0872 20.1103
NCI-H748 GDSC1 2.6812 6.9016 0.9937 20.7053
NCI-H69 GDSC1 2.7149 8.9746 -0.0039 26.3233
COR-L23 GDSC1 2.7648 8.5166 0.2679 24.7096
NCI-H520 GDSC1 2.7957 8.9627 0.0731 25.602
LCLC-103H GDSC1 2.8504 5.9151 1.6342 15.4495
NCI-H650 GDSC1 2.9613 9.3064 0.0459 25.0689
NCI-H226 GDSC1 3.0452 3.9543 2.7703 5.8849
NCI-H292 GDSC1 3.053 6.7202 1.4152 16.2356
NCI-H1436 GDSC1 3.0738 6.6744 1.4563 15.8547
NCI-H2087 GDSC1 3.0755 7.6512 0.9705 19.2252
HCC44 GDSC1 3.0816 4.8657 2.3619 8.8951
Lu-65 GDSC1 3.1365 9.2037 0.2474 23.3218
NCI-H2804 GDSC1 3.1777 7.5907 1.0884 18.0357
NCI-H1792 GDSC1 3.1934 5.723 2.0345 11.0124
HCC33 GDSC1 3.2315 8.7989 0.5302 21.3582
CAL-12T GDSC1 3.2485 5.746 2.0703 10.5237
NCI-H1581 GDSC1 3.2548 10.2092 -0.1552 24.927
RERF-LC-KJ GDSC1 3.2572 11.0419 -0.5695 26.7974
NCI-H187 GDSC1 3.258 10.5141 -0.305 25.6219
SK-MES-1 GDSC1 3.2973 5.7977 2.086 10.2195
NCI-H64 GDSC1 3.3517 4.0554 3.0028 2.8025
NCI-H1648 GDSC1 3.3593 5.2439 2.4149 7.4107
SK-LU-1 GDSC1 3.3796 6.064 2.0217 10.4182
NCI-H1563 GDSC1 3.3826 5.2859 2.4132 7.3404
Ms-1 GDSC1 3.389 5.5262 2.2984 8.2205
NCI-H1836 GDSC1 3.3928 7.4667 1.3313 15.5351
NCI-H1437 GDSC1 3.4052 6.7598 1.695 12.8266
NCI-H2030 GDSC1 3.4172 8.1009 1.0345 17.49
NCI-H1568 GDSC1 3.4258 6.9365 1.6236 13.2861
COR-L88 GDSC1 3.4263 7.0192 1.5828 13.5874
LOU-NH91 GDSC1 3.4287 9.6057 0.2916 21.9719
NCI-H2141 GDSC1 3.4398 12.5428 -1.1676 28.4944
NCI-H1876 GDSC1 3.4414 11.4734 -0.6317 26.3947
NCI-H596 GDSC1 3.4548 7.1397 1.5459 13.7565
CPC-N GDSC1 3.4672 8.6383 0.8071 18.7825
NCI-H1944 GDSC1 3.4844 8.4424 0.9191 18.0018
NCI-H2228 GDSC1 3.5171 6.9833 1.6749 12.5763
UMC-11 GDSC1 3.5225 9.6468 0.3484 21.313
NCI-H460 GDSC1 3.5283 4.5184 2.9115 2.9306
Lu-135 GDSC1 3.5334 7.228 1.5659 13.3286
HOP-62 GDSC1 3.5682 7.6266 1.395 14.4468
NCI-H2818 GDSC1 3.5742 5.3703 2.5245 5.8098
PaCa-3 GDSC1 3.6315 7.2858 1.6159 12.6167
NCI-H727 GDSC1 3.6874 7.4203 1.5931 12.5936
NCI-H2135 GDSC1 3.7157 6.8228 1.9126 10.0991
NCI-H2170 GDSC1 3.7175 8.3279 1.1646 15.5356
NCI-H2122 GDSC1 3.7276 8.3713 1.151 15.5935
DMS 114 GDSC1 3.7475 6.3482 2.1724 7.9985
NCI-H2196 GDSC1 3.7486 8.6305 1.0385 16.2777
Calu-6 GDSC1 3.7521 6.4169 2.1419 8.2198
RERF-LC-Sq1 GDSC1 3.7539 11.4689 -0.3737 24.1649
NCI-H1688 GDSC1 3.7742 8.628 1.06 16.0461
NCI-H838 GDSC1 3.787 6.3776 2.1878 7.7556
A-549 GDSC1 3.8434 7.5864 1.6321 11.786
NCI-H1770 GDSC1 3.8564 8.5548 1.1611 15.0857
DMS 273 GDSC1 3.9583 13.706 -1.3259 27.3495
NCI-H1651 GDSC1 3.9915 5.8329 2.5988 4.0252
NCI-H841 GDSC1 3.996 5.9814 2.5309 4.5231
NCI-H345 GDSC1 4.0103 4.8964 3.0386 0.9086
BEN GDSC1 4.0398 7.7985 1.6758 10.8395
DMS 79 GDSC1 4.046 7.4892 1.8325 9.6607
Lu-165 GDSC1 4.0638 8.7232 1.2371 13.8849
NCI-H510A GDSC1 4.0784 8.6405 1.2891 13.4805
Calu-3 GDSC1 4.0788 8.3052 1.455 12.3146
HCC827 GDSC1 4.104 7.4398 1.8991 8.9902
COR-L105 GDSC1 4.1213 10.9747 0.1643 20.2561
NCI-H1915 GDSC1 4.1266 10.4658 0.4212 18.8176
NCI-H1734 GDSC1 4.1359 10.007 0.6561 17.4053
SHP-77 GDSC1 4.1383 5.5299 2.8311 2.0212
ChaGo-K-1 GDSC1 4.1518 10.7555 0.2969 19.4346
NCI-H1693 GDSC1 4.156 11.41 -0.0252 21.1324
NCI-H1993 GDSC1 4.1568 6.0685 2.595 3.6464
NCI-H1092 GDSC1 4.165 9.9933 0.6852 17.1348
COR-L95 GDSC1 4.1655 7.3771 1.9737 8.2532
SBC-1 GDSC1 4.1802 5.9935 2.6446 3.2355
NCI-H1838 GDSC1 4.1958 6.1868 2.5644 3.7772
NCI-H1975 GDSC1 4.2427 6.4062 2.4915 4.1961
NCI-H1650 GDSC1 4.3413 8.4962 1.5537 10.8162
COR-L303 GDSC1 4.3883 13.2767 -0.7723 23.8579
HOP-92 GDSC1 4.3956 8.9064 1.3924 11.7924
LC-1/sq GDSC1 4.4543 7.6476 2.0422 6.9608
NCI-H2085 GDSC1 4.5132 7.3753 2.2096 5.5957
NCI-H2369 GDSC1 4.5319 7.0827 2.3577 4.4908
SBC-5 GDSC1 4.5661 9.9194 1.0201 13.7897
COLO 668 GDSC1 4.5753 10.2656 0.8573 14.7994
NCI-H2803 GDSC1 4.5838 8.2123 1.8592 7.9528
NCI-H1355 GDSC1 4.5856 8.6708 1.6405 9.5114
NCI-H23 GDSC1 4.5874 8.2214 1.8573 7.9571
NCI-H2029 GDSC1 4.6164 11.9919 0.0383 19.3643
NCI-H3255 GDSC1 4.6346 9.9452 1.0567 13.3526
NCI-H1869 GDSC1 4.6362 7.8325 2.0736 6.279
NCI-H2591 GDSC1 4.6699 8.4973 1.7808 8.2911
NCI-H1155 GDSC1 4.6803 8.8268 1.6302 9.3294
Lu-139 GDSC1 4.6994 14.0483 -0.9159 23.5195
NCI-H1666 GDSC1 4.7018 8.0111 2.0318 6.4203
NCI-H2444 GDSC1 4.7158 6.0007 2.9229 0.6818
NCI-H2347 GDSC1 4.7163 6.9438 2.5289 2.9419
NCI-H522 GDSC1 4.916 10.6532 0.9117 13.481
NCI-H2595 GDSC1 4.9185 6.7311 2.7245 1.4455
NCI-H661 GDSC1 4.9218 10.7673 0.8604 13.784
NCI-H2009 GDSC1 4.9389 7.2239 2.5276 2.5653
NCI-H322M GDSC1 4.965 6.9309 2.6648 1.7136
NCI-H1573 GDSC1 4.9723 7.1946 2.5576 2.3285
IA-LM GDSC1 4.9732 7.3195 2.5045 2.6522
NCI-H513 GDSC1 4.9833 7.1194 2.5951 2.0884
NCI-H290 GDSC1 5.0023 7.2084 2.5672 2.2252
NCI-H2172 GDSC1 5.053 6.3145 2.9434 0.3641
NCI-H2461 GDSC1 5.0814 7.7773 2.3638 3.3565
RERF-LC-MS GDSC1 5.109 6.7957 2.7859 0.9314
NCI-H2373 GDSC1 5.2192 7.1813 2.6834 1.306
NCI-H1781 GDSC1 5.268 6.6517 2.9047 0.3694
SW1573 GDSC1 5.2966 14.0691 -0.4819 19.9483
HCC78 GDSC1 5.4439 13.9722 -0.3285 18.8354
NCI-H2342 GDSC1 5.4576 9.4543 1.8293 6.1378
NCI-H2110 GDSC1 5.4696 12.1955 0.5497 14.1684
NCI-H1435 GDSC1 5.4906 6.9457 2.884 0.3234
NCI-H1299 GDSC1 5.5361 10.4214 1.4327 8.5698
NCI-H2405 GDSC1 5.5497 12.3515 0.5291 14.0802
NCI-H720 GDSC1 5.5999 7.0601 2.8843 0.2791
EKVX GDSC1 5.6189 8.3236 2.4087 2.2683
NCI-H2291 GDSC1 5.6438 7.72 2.6601 1.0049
NCI-H2023 GDSC1 5.6774 7.5514 2.7374 0.679
DMS 53 GDSC1 5.6848 7.4515 2.7769 0.5405
NCI-H1623 GDSC1 5.7218 8.1186 2.5394 1.4752
NCI-H3122 GDSC1 5.9003 10.0057 1.8358 5.2456
NCI-H1793 GDSC1 6.021 8.3872 2.5653 1.0876
NCI-H441 GDSC1 6.133 12.4599 0.8579 10.782
HCC15 GDSC1 6.539 14.3476 0.2325 13.3414
⏷ Show the Full List of 172 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1 3.0746 11.4996 -0.9525 29.0044
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE-15 GDSC1 3.3277 6.4717 1.7746 12.5084
TE-8 GDSC1 3.4465 7.6816 1.2683 15.7823
KYSE-270 GDSC1 3.5018 6.6778 1.8151 11.5724
KYSE-150 GDSC1 3.7319 4.9089 2.8662 2.6967
KYSE-520 GDSC1 3.7732 6.3041 2.2137 7.5985
TE-5 GDSC1 3.8149 5.8828 2.4517 5.6317
KYSE-410 GDSC1 3.8202 5.8453 2.4739 5.4456
TE-6 GDSC1 3.8761 8.9619 0.9739 16.2669
KYSE-450 GDSC1 4.0731 9.3709 0.9234 15.9413
KYSE-510 GDSC1 4.0755 5.9466 2.6001 3.8049
TE-9 GDSC1 4.1243 5.9789 2.6163 3.5688
KYSE-140 GDSC1 4.1839 9.3988 0.9939 15.1284
TE-4 GDSC1 4.2422 6.732 2.3372 5.331
KYSE-70 GDSC1 4.354 7.9946 1.8067 8.9536
COLO 680N GDSC1 4.4854 6.0953 2.7737 1.777
TE-1 GDSC1 4.5861 9.7015 1.1409 12.9408
TE-11 GDSC1 4.632 7.1086 2.4064 3.9335
TE-10 GDSC1 4.7047 7.9627 2.0564 6.2385
OE21 GDSC1 5.1004 7.2095 2.6158 1.8061
OE19 GDSC1 5.4816 6.6284 2.9899 0.1102
KYSE-180 GDSC1 5.8958 12.4873 0.6939 12.2824
EC-GI-10 GDSC1 6.0733 7.7208 2.8265 0.2467
T.T GDSC1 6.0896 7.7489 2.8227 0.2495
OE33 GDSC1 6.3668 8.1071 2.7984 0.2187
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A2780 GDSC1 -0.9188 3.8089 -1.4403 52.5085
TOV-112D GDSC1 0.4221 11.0442 -3.1418 44.8
Caov-3 GDSC1 0.5199 3.5791 0.1972 37.1656
TOV-21G GDSC1 2.6696 4.5269 2.1325 12.4618
OV-90 GDSC1 2.9424 7.7621 0.7996 20.8631
FU-OV-1 GDSC1 3.4779 6.7994 1.7349 12.2647
OVK18 GDSC1 3.5002 4.6728 2.8136 3.7846
OC 314 GDSC1 3.5034 9.4781 0.417 20.9943
ES-2 GDSC1 3.5485 5.604 2.3882 6.9628
OVCAR-5 GDSC1 3.8258 8.429 1.1997 14.9254
EFO-21 GDSC1 3.9396 9.527 0.7425 17.5259
Caov-4 GDSC1 3.9665 8.9743 1.0382 15.5425
OVCAR-8 GDSC1 3.9914 7.5172 1.7784 10.2311
OVKATE GDSC1 4.1572 7.6524 1.8335 9.3213
IGROV-1 GDSC1 4.1735 12.028 -0.3189 22.5157
RMG-I GDSC1 4.1873 9.5697 0.9119 15.6469
OVTOKO GDSC1 4.3079 7.4594 2.0333 7.4134
JHOS-2 GDSC1 4.3205 8.8445 1.3683 12.1827
OAW42 GDSC1 4.4057 10.6892 0.5234 17.3377
SK-OV-3 GDSC1 4.6153 10.5315 0.7561 15.3078
OV56 GDSC1 4.6508 8.4269 1.8017 8.1915
OVISE GDSC1 4.8316 10.5241 0.9149 13.6965
EFO-27 GDSC1 4.8472 7.764 2.236 4.6595
Kuramochi GDSC1 4.8835 7.6495 2.3091 4.0867
OAW28 GDSC1 5.062 15.0361 -1.1303 23.3423
DOV13 GDSC1 5.1956 6.8104 2.8172 0.7228
OVCAR-3 GDSC1 5.4571 9.5561 1.7827 6.4461
TYK-nu GDSC1 5.9283 7.9381 2.6951 0.6669
OVCAR-4 GDSC1 6.09 7.9692 2.746 0.4285
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KP-4 GDSC1 0.8509 3.9551 0.4379 33.7268
HuP-T4 GDSC1 1.1097 5.5123 0.1041 33.7663
KP-2 GDSC1 2.074 4.3882 1.5843 19.4179
HPAC GDSC1 2.2064 6.5558 0.7201 24.6002
PSN1 GDSC1 2.3843 6.1571 1.0815 21.4443
PaTu 8902 GDSC1 2.7002 5.9342 1.4866 17.1809
MZ-PC-1 GDSC1 3.0227 4.978 2.2529 9.9866
PaTu 8988t GDSC1 3.0328 6.74 1.3878 16.5142
SUIT-2 GDSC1 3.3326 5.3979 2.3156 8.2898
Capan-2 GDSC1 3.3572 7.082 1.4941 14.4936
BxPC-3 GDSC1 3.4868 8.2159 1.0343 17.2355
KP-1N GDSC1 3.5137 5.79 2.2679 8.0234
HuP-T3 GDSC1 3.6807 7.3449 1.6254 12.3777
CFPAC-1 GDSC1 3.9241 6.4251 2.2654 6.7428
DAN-G GDSC1 3.9894 6.9867 2.0378 8.2864
Panc 10.05 GDSC1 4.0342 9.6024 0.7785 16.9868
SU.86.86 GDSC1 4.0676 9.0777 1.0645 15.037
Panc 08.13 GDSC1 4.0746 6.0486 2.5513 4.168
MIA PaCa-2 GDSC1 4.2302 14.8531 -1.6811 27.7276
Capan-1 GDSC1 4.2386 6.7241 2.3387 5.3296
KP-3 GDSC1 4.3066 7.2629 2.1268 6.7237
Panc 03.27 GDSC1 4.4609 8.0531 1.8524 8.3273
Panc 02.03 GDSC1 4.4862 9.4127 1.2102 12.771
Hs 766T GDSC1 4.532 6.589 2.5826 2.932
AsPC-1 GDSC1 4.5485 6.7797 2.5064 3.4168
HPAF-II GDSC1 4.5531 7.1435 2.3427 4.55
YAPC GDSC1 4.5619 8.5629 1.6762 9.3223
Panc 04.03 GDSC1 4.5758 6.3856 2.6965 2.1102
SW1990 GDSC1 4.7734 8.923 1.6468 8.9688
PL4 GDSC1 5.5802 7.3633 2.7679 0.6344
QGP-1 GDSC1 6.0177 14.3774 -0.1252 16.3808
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MPP 89 GDSC1 3.5101 4.9003 2.7083 4.5779
NCI-H2052 GDSC1 3.9188 6.0339 2.4523 5.329
NCI-H2452 GDSC1 4.0633 6.4577 2.3478 5.7223
MSTO-211H GDSC1 4.0726 6.1045 2.5234 4.3801
IST-Mes1 GDSC1 4.115 6.8297 2.2039 6.6665
NCI-H28 GDSC1 4.773 6.9306 2.5659 2.6023
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
VCaP GDSC1 3.4113 7.1364 1.5118 14.1653
PC-3 GDSC1 4.429 10.4533 0.6571 16.4721
22Rv1 GDSC1 5.9744 9.515 2.0879 3.5933
LNCaP clone FGC GDSC1 6.0584 8.1639 2.6638 0.6934
DU145 GDSC1 6.2052 7.9984 2.7781 0.3061
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1 4.9544 9.3372 1.5697 9.0411
Cancer Drug Sensitivity Data Curated from 56 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IGR-1 GDSC1 0.1684 3.4655 -0.1532 41.2204
A-431 GDSC1 0.3138 5.064 -0.5478 41.3482
Mel JuSo GDSC1 1.3939 5.289 0.4942 30.1335
Hs 940.T GDSC1 1.4212 4.3501 0.9091 27.5176
A-375 GDSC1 1.9748 5.313 1.077 23.4536
LOX-IMVI GDSC1 2.0615 5.0118 1.3004 21.4916
A101D GDSC1 2.8781 6.8088 1.2168 18.3561
CHL-1 GDSC1 2.8886 6.9425 1.1599 18.7065
RPMI-7951 GDSC1 3.0061 4.467 2.4875 8.233
Mel Ho GDSC1 3.0359 7.5017 1.0108 19.1165
A2058 GDSC1 3.2505 8.7038 0.5938 20.9083
SK-MEL-3 GDSC1 3.3187 6.2962 1.8548 11.9298
WM1552C GDSC1 3.3214 4.7809 2.6146 5.9756
SK-MEL-2 GDSC1 3.3421 4.1319 2.9565 3.203
WT2-iPS GDSC1 3.3584 4.1285 2.9718 3.0229
G-mel GDSC1 3.3591 5.5793 2.247 8.732
M14 GDSC1 3.435 5.3385 2.4299 7.0234
WM35 GDSC1 3.487 5.1785 2.5516 5.8865
CP66-MEL GDSC1 3.5473 4.812 2.7807 3.8915
MZ-MEL-7 GDSC1 3.5618 6.9901 1.7076 12.1743
MZ-MEL-2 GDSC1 3.5693 7.2619 1.5779 13.1137
SK-MEL-30 GDSC1 3.6334 9.37 0.577 19.5923
A-388 GDSC1 3.6852 7.0391 1.7812 11.1981
IPC-298 GDSC1 3.695 7.7451 1.4373 13.7013
RVH-421 GDSC1 3.6991 6.0018 2.3072 7.1065
SK-MEL-5 GDSC1 3.7297 5.6122 2.5223 5.3403
WM278 GDSC1 3.8285 7.5037 1.6617 11.616
IST-MEL1 GDSC1 3.8675 8.327 1.283 14.21
MMAc-SF GDSC1 3.9014 7.4967 1.7209 10.9421
COLO 679 GDSC1 4.0062 7.2511 1.9203 9.1237
G-361 GDSC1 4.0433 9.5425 0.8153 16.7261
HMV-II GDSC1 4.0562 10.1695 0.5139 18.5128
GAK GDSC1 4.1496 6.2521 2.504 4.3303
SK-MEL-1 GDSC1 4.1555 7.0009 2.1493 6.9648
SH-4 GDSC1 4.196 8.4996 1.4463 12.0132
IGR-37 GDSC1 4.2307 8.9625 1.2442 13.3109
WM793 GDSC1 4.4347 10.2125 0.78 15.7044
LB373-MEL-D GDSC1 4.4575 6.2379 2.6966 2.3156
HT-144 GDSC1 4.4676 9.6136 1.0984 13.57
COLO 792 GDSC1 4.4975 8.3363 1.7411 9.0327
WM115 GDSC1 4.6743 8.2244 1.9134 7.3335
SK-MEL-28 GDSC1 4.734 5.7179 3.0356 0.2523
MeWo GDSC1 4.7765 6.3385 2.8168 1.13
COLO 783 GDSC1 4.829 6.1378 2.9187 0.603
451Lu GDSC1 4.8422 6.6655 2.7145 1.6002
UACC-257 GDSC1 4.9298 9.0371 1.6957 8.2338
Hs 938.T GDSC1 4.9552 7.3052 2.5012 2.703
COLO 800 GDSC1 4.9776 12.9277 -0.1547 19.281
UACC-62 GDSC1 5.0318 6.0695 3.0221 0.1675
LB2518-MEL GDSC1 5.2226 7.5667 2.5278 2.1362
VMRC-MELG GDSC1 5.3103 6.7972 2.8685 0.4585
DJM-1 GDSC1 5.4022 7.5857 2.6059 1.4911
CP50-MEL-B GDSC1 5.5092 6.9977 2.8726 0.3457
COLO 829 GDSC1 5.9643 7.667 2.8058 0.3288
SK-MEL-24 GDSC1 8.113 17.8028 -0.3932 13.1621
EquiPSC Line K2 GDSC1 5.1103 7.1706 2.6366 1.6787
⏷ Show the Full List of 56 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1 -1.9645 -0.2623 -1.9661 66.2175
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
EW-8 GDSC1 -2.1296 -1.1778 -2.1296 68.5552
STS-0421 GDSC1 -0.4709 1.6541 -0.5072 47.9065
G-402 GDSC1 -0.4326 3.9943 -0.969 47.998
Rh41 GDSC1 -0.3124 2.8398 -0.5192 46.3403
A-204 GDSC1 -0.1546 4.1701 -0.7248 45.3113
MES-SA GDSC1 1.1966 5.1174 0.3621 31.9851
RKN GDSC1 2.3669 6.1894 1.0493 21.7403
Rh18 GDSC1 2.5816 4.2177 2.1836 12.4975
TE 441.T GDSC1 2.6683 7.3303 0.7703 22.1977
G-401 GDSC1 3.0478 6.6205 1.4604 15.9279
Hs 633.T GDSC1 3.1433 5.1774 2.2626 9.4247
GCT GDSC1 3.3344 4.3222 2.8549 4.0325
SK-UT-1 GDSC1 3.5791 6.6399 1.8962 10.6844
VA-ES-BJ GDSC1 3.6058 5.8471 2.3121 7.3693
SK-LMS-1 GDSC1 3.7156 9.5879 0.5346 19.5524
MFH-ino GDSC1 4.1027 7.3391 1.9474 8.6323
HT-1080 GDSC1 4.303 9.1473 1.2068 13.3432
Rh30 GDSC1 4.3569 8.3188 1.6513 10.0724
RD GDSC1 4.3996 8.2408 1.7192 9.4615
KYM-1 GDSC1 4.6511 6.2147 2.8074 1.336
SW684 GDSC1 4.756 5.9972 2.9414 0.5689
SW872 GDSC1 4.8676 7.3905 2.4158 3.4058
SW982 GDSC1 5.1804 6.5414 2.9107 0.397
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Hs 746.T GDSC1 1.0224 6.2092 -0.2908 35.9446
HSC-39 GDSC1 1.0884 5.3199 0.164 33.614
ECC10 GDSC1 1.7893 5.4473 0.829 26.0092
HGC-27 GDSC1 2.014 6.464 0.5791 26.3724
Fu97 GDSC1 2.1319 3.9561 1.819 17.4392
RF-48 GDSC1 2.4574 7.6881 0.4021 25.3006
SNU-1 GDSC1 2.5619 6.4949 1.0841 20.6231
RERF-GC-1B GDSC1 2.5691 7.6967 0.4994 24.2551
IM95 GDSC1 2.7996 10.4044 -0.6418 28.8417
MKN7 GDSC1 3.6078 5.7419 2.366 6.9414
OCUM-1 GDSC1 3.852 8.4328 1.2183 14.709
NUGC-4 GDSC1 3.994 5.9341 2.5522 4.3682
MKN1 GDSC1 4.0002 8.5662 1.2665 13.8878
23132/87 GDSC1 4.0049 6.2648 2.4006 5.4829
NUGC-3 GDSC1 4.3761 7.98 1.8292 8.7282
MKN28 GDSC1 4.4067 7.5171 2.0727 6.8607
SNU-16 GDSC1 4.6054 9.8405 1.0869 13.2403
MKN45 GDSC1 4.9318 11.5498 0.4866 15.9877
SCH GDSC1 5.2443 6.4652 2.9618 0.2284
TGBC11TKB GDSC1 5.3024 7.08 2.7597 0.8733
GCIY GDSC1 5.305 9.1522 1.8761 6.1436
TMK-1 GDSC1 5.3595 7.6402 2.5639 1.7577
SNU-5 GDSC1 5.5715 6.9169 2.9236 0.2027
NCI-N87 GDSC1 6.5166 8.6436 2.6668 0.4536
AGS GDSC1 6.9851 16.2469 -0.3739 15.3416
SNG-M GDSC1 2.4299 5.0784 1.6389 17.2762
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CGTH-W-1 GDSC1 1.9564 6.3475 0.5784 26.6629
KMH-2 GDSC1 2.1709 4.9325 1.4469 19.9141
8505C GDSC1 2.6415 7.6119 0.6068 23.3105
B-CPAP GDSC1 2.7921 5.2781 1.8924 13.7433
IHH-4 GDSC1 2.8637 7.3771 0.9219 20.4035
ML-1 [Human leukemia] GDSC1 3.0384 7.7431 0.8925 19.8819
TT GDSC1 3.3148 5.64 2.1796 9.4225
TT2609-C02 GDSC1 3.4851 9.3925 0.4448 20.9024
WRO GDSC1 3.5419 4.9308 2.7178 4.4005
ASH-3 GDSC1 3.5639 5.7559 2.3247 7.4093
BHT-101 GDSC1 3.7613 5.397 2.6505 4.2578
CAL-62 GDSC1 3.8058 7.6343 1.5793 12.2974
K5 GDSC1 3.897 7.0827 1.9222 9.4448
HTC-C3 GDSC1 3.9723 5.9031 2.5523 4.4242
8305C GDSC1 4.4235 9.268 1.2357 12.7846
FTC-133 GDSC1 5.2233 6.7943 2.8348 0.6333
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
UPCI-SCC-090 GDSC1 1.8452 9.1881 -0.8982 33.8571
NCI-H3118 GDSC1 2.1815 6.1942 0.8695 23.7877
OSC-20 GDSC1 2.3209 5.5911 1.2911 20.2964
PCI-30 GDSC1 3.1519 4.136 2.7853 5.3008
PCI-04B GDSC1 3.1701 7.3677 1.1933 17.3474
CAL-33 GDSC1 3.276 8.2575 0.8384 19.3004
SCC-15 GDSC1 3.2782 6.6052 1.6662 13.5118
SCC-25 GDSC1 3.2832 9.6025 0.1719 23.1638
BICR 10 GDSC1 3.4294 4.5999 2.7942 4.1735
HO-1-N-1 GDSC1 3.5786 7.416 1.5085 13.5901
BB30-HNC GDSC1 3.7779 8.8692 0.9428 16.8056
SAS GDSC1 3.8288 7.9336 1.4484 13.1697
OSC-19 GDSC1 3.8437 7.7066 1.5727 12.221
CAL-27 GDSC1 3.8589 9.8984 0.494 19.2928
PCI-15A GDSC1 3.8933 8.0925 1.4194 13.1642
JHU-011 GDSC1 3.8966 8.2269 1.3552 13.6078
BICR 22 GDSC1 3.9671 5.9994 2.5026 4.8135
DOK GDSC1 3.9842 7.3813 1.84 9.7938
BB49-HNC GDSC1 3.9884 9.2656 0.9103 16.3038
SAT [Human HNSCC] GDSC1 4.1176 6.8201 2.2103 6.6109
FaDu GDSC1 4.2429 7.9944 1.728 9.8465
HO-1-u-1 GDSC1 4.2836 7.8355 1.8344 8.9496
PCI-06A GDSC1 4.4262 12.4894 -0.3523 21.8749
LB771-HNC GDSC1 4.4297 8.3827 1.6716 9.7203
BICR 78 GDSC1 4.4827 7.3009 2.225 5.5582
HSC-3 GDSC1 4.52 9.9866 0.9538 14.3533
Ca9-22 GDSC1 4.5682 7.2515 2.302 4.8048
SKN-3 GDSC1 4.6047 6.9449 2.4646 3.5893
BHY GDSC1 4.6231 12.0002 0.0392 19.3388
KON GDSC1 4.685 9.0197 1.5407 9.9433
SCC-9 GDSC1 4.7307 9.7321 1.2283 11.9496
PCI-38 GDSC1 4.8871 8.4904 1.9251 6.7359
PE/CA-PJ15 GDSC1 4.9094 8.939 1.7288 8.0541
SCC-4 GDSC1 5.135 7.5638 2.4846 2.5174
BICR 31 GDSC1 5.1669 10.1865 1.3065 10.2759
JHU-022 GDSC1 5.1757 10.052 1.3761 9.795
Detroit 562 GDSC1 5.4215 11.6719 0.7681 13.0135
HSC-4 GDSC1 5.5093 7.0225 2.8639 0.3696
HSC-2 GDSC1 5.8007 10.3771 1.613 6.8426
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
5637 GDSC1 0.425 3.7539 0.0405 38.5389
BFTC-905 GDSC1 0.7657 4.8514 0.016 36.3018
RT-112 GDSC1 0.8521 5.2407 -0.0499 36.0247
RT-4 GDSC1 1.8707 7.6676 -0.1352 30.7532
UM-UC-3 GDSC1 2.8621 5.4835 1.8571 13.7145
SW1710 GDSC1 3.1693 4.7433 2.5013 7.4504
SW780 GDSC1 3.6373 5.2613 2.6266 4.8125
639V GDSC1 4.3549 9.5135 1.065 14.1299
KU-19-19 GDSC1 4.4105 6.816 2.406 4.4213
TCCSUP GDSC1 4.4673 6.5448 2.565 3.1798
647V GDSC1 4.4826 8.8808 1.467 11.0201
CAL-29 GDSC1 4.6789 6.3908 2.7479 1.6374
HT-1197 GDSC1 5.1729 6.7629 2.8257 0.7064
T24 GDSC1 5.8667 12.0202 0.895 11.1677
HT-1376 GDSC1 5.8849 7.5116 2.8309 0.2991
J82 GDSC1 6.1223 8.1998 2.6757 0.6173
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BPH-1 GDSC1 -1.11 1.4408 -1.1585 55.4576
SW954 GDSC1 -0.8398 2.151 -0.9592 52.2017
PA-1 GDSC1 -0.3631 2.1888 -0.4539 46.7097
KGN GDSC1 0.9741 4.374 0.4217 33.0283
SW962 GDSC1 1.5434 2.9291 1.476 23.0915
Ca Ski GDSC1 1.5954 6.7075 0.0556 31.2717
SKN GDSC1 2.1608 4.7143 1.5339 19.341
ME-180 GDSC1 2.3872 8.0737 0.1482 26.9722
NT2-D1 GDSC1 2.7602 6.7364 1.1469 19.3345
LB831-BLC GDSC1 3.0002 4.2544 2.5843 7.5116
JAR GDSC1 3.1798 4.839 2.4631 7.7091
NCC-IT GDSC1 3.2623 8.4956 0.7078 20.171
DSH1 GDSC1 3.3464 4.7825 2.6348 5.7242
NEC8 GDSC1 3.3594 4.9017 2.586 6.0617
HEY GDSC1 3.4757 6.6481 1.8087 11.7125
PEO1 GDSC1 3.7521 8.2247 1.2435 14.8738
OMC-1 [Human cervical carcinoma] GDSC1 3.8944 7.2006 1.8619 9.9086
ACC-OV7 GDSC1 4.008 7.3006 1.8973 9.2911
HT-3 GDSC1 4.0312 6.6166 2.2485 6.5634
SiHa GDSC1 4.1577 6.0062 2.6246 3.4301
OV17R GDSC1 4.1775 7.4495 1.947 8.4182
DoTc2 4510 GDSC1 4.1915 6.9425 2.2023 6.4693
SiSo GDSC1 4.4523 8.0662 1.8402 8.439
HeLa GDSC1 4.4613 7.7967 1.9756 7.4287
C-4-I GDSC1 4.4815 7.0397 2.3464 4.6857
OVCA433 GDSC1 4.4949 9.3814 1.2317 12.6005
C-33 A GDSC1 4.6811 9.104 1.4974 10.2552
OVMIU GDSC1 4.726 11.0919 0.562 16.1443
CAL-39 GDSC1 4.8228 7.5478 2.3196 4.1372
UWB1.289 GDSC1 4.8527 9.3715 1.4857 9.8782
SKG-IIIa GDSC1 4.8617 6.9093 2.6219 2.1113
OVCA420 GDSC1 4.8694 7.0914 2.5478 2.5536
MS751 GDSC1 4.8766 9.9359 1.231 11.5318
HEC-1 GDSC1 5.1998 7.3817 2.5931 1.8011
JHOS-3 GDSC1 5.3338 7.7283 2.5155 2.054
SW756 GDSC1 5.3624 6.5233 2.984 0.1466
JEG-3 GDSC1 5.4386 6.8979 2.8815 0.3534
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug

References

1 Role of Akt signaling in vascular homeostasis and angiogenesis. Circ Res. 2002 Jun 28;90(12):1243-50.
2 Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1. J Biol Chem. 2005 May 20;280(20):19867-74.