Details of the Drug

General Information of Drug (ID: DMZAL8C)

Drug Name
Motesanib
Synonyms N-(2,3-dihydro-3,3-dimethyl-1H-indol-6-yl)-2-((4-pyridinylmethyl)amino)-3-pyridinecarboxamide; N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyridin-4-ylmethyl)amino]pyridine-3-carboxamide
Indication
Disease Entry ICD 11 Status REF
Non-small-cell lung cancer 2C25.Y Discontinued in Phase 3 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 373.5
Logarithm of the Partition Coefficient (xlogp) 3.9
Rotatable Bond Count (rotbonds) 5
Hydrogen Bond Donor Count (hbonddonor) 3
Hydrogen Bond Acceptor Count (hbondacc) 5
Chemical Identifiers
Formula
C22H23N5O
IUPAC Name
N-(3,3-dimethyl-1,2-dihydroindol-6-yl)-2-(pyridin-4-ylmethylamino)pyridine-3-carboxamide
Canonical SMILES
CC1(CNC2=C1C=CC(=C2)NC(=O)C3=C(N=CC=C3)NCC4=CC=NC=C4)C
InChI
InChI=1S/C22H23N5O/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3-9-24-20(17)25-13-15-7-10-23-11-8-15/h3-12,26H,13-14H2,1-2H3,(H,24,25)(H,27,28)
InChIKey
RAHBGWKEPAQNFF-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
11667893
ChEBI ID
CHEBI:51098
CAS Number
453562-69-1
UNII
U1JK633AYI
DrugBank ID
DB05575
TTD ID
D00DQX
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Platelet-derived growth factor receptor (PDGFR) TTI2WET NOUNIPROTAC Inhibitor [2]
Tyrosine-protein kinase Kit (KIT) TTX41N9 KIT_HUMAN Inhibitor [2]
Vascular endothelial growth factor receptor 2 (KDR) TTUTJGQ VGFR2_HUMAN Inhibitor [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Non-small-cell lung cancer
ICD Disease Classification 2C25.Y
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Tyrosine-protein kinase Kit (KIT) DTT KIT 2.06E-01 -0.1 -0.14
Vascular endothelial growth factor receptor 2 (KDR) DTT KDR 1.98E-01 0.11 0.2
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1; GDSC2 5.4116 7.518 2.6047 0.9948
CHSA0011 GDSC1; GDSC2 2.7459 25.8754 -8.4384 39.4806
HuO9 GDSC1; GDSC2 3.6085 12.3467 -0.954 22.7572
HuO-3N1 GDSC1; GDSC2 3.835 10.0729 0.3639 16.0932
EW-18 GDSC1; GDSC2 4.8258 9.9445 1.1647 9.3743
H-EMC-SS GDSC1; GDSC2 4.9078 21.2155 -4.34 29.3977
EW-7 GDSC1; GDSC2 4.9472 7.1542 2.5307 1.7602
ES1 GDSC1; GDSC2 4.9537 10.4477 1.0102 9.9514
SK-PN-DW GDSC1; GDSC2 4.9971 20.2275 -3.7786 27.9699
EW-24 GDSC1; GDSC2 5.1044 6.322 2.9268 0.2111
SaOS-2 GDSC1; GDSC2 5.1253 7.8264 2.3357 2.4709
CADO-ES1 GDSC1; GDSC2 5.1771 6.5959 2.8564 0.344
CAL-72 GDSC1; GDSC2 5.2651 7.0007 2.7414 0.6274
CHSA8926 GDSC1; GDSC2 5.3233 14.318 -0.6105 17.0608
EW-1 GDSC1; GDSC2 5.3275 14.2519 -0.5751 16.9001
A-673 GDSC1; GDSC2 5.3843 7.379 2.6471 0.8631
SJSA-1 GDSC1; GDSC2 5.4697 7.313 2.7086 0.605
EW-12 GDSC2 5.505 7.3721 2.701 0.6294
MHH-ES-1 GDSC1; GDSC2 5.5528 7.1626 2.7969 0.3301
HOS GDSC1; GDSC2 5.5948 6.9556 2.8848 0.1509
U-CH2 GDSC2 5.6445 7.4552 2.7265 0.4796
TC-71 GDSC1; GDSC2 5.7102 7.2958 2.8087 0.2508
MG-63 GDSC1; GDSC2 5.7531 10.4092 1.5409 5.6109
ES5 GDSC1; GDSC2 5.7953 9.5779 1.9353 3.5468
SK-ES-1 GDSC1; GDSC2 5.863 7.5607 2.7721 0.2741
ES8 GDSC1; GDSC2 5.8973 7.6761 2.7441 0.3192
EW-22 GDSC1; GDSC2 5.9934 7.8811 2.7075 0.3633
U2OS GDSC1; GDSC2 6.0028 7.8953 2.706 0.3632
NOS-1 [Human HNSCC] GDSC1; GDSC2 6.0074 8.0752 2.6429 0.511
EW-13 GDSC1; GDSC2 6.0976 13.4856 0.3254 11.1779
EW-11 GDSC1; GDSC2 6.1092 8.9025 2.3717 1.3031
CHSA0108 GDSC1; GDSC2 6.1211 8.1873 2.6465 0.4528
CAL-78 GDSC1; GDSC2 6.1283 7.9977 2.7166 0.2989
ES6 GDSC1; GDSC2 6.1377 8.5368 2.5244 0.7735
EW-16 GDSC1; GDSC2 6.1587 8.3182 2.6137 0.5168
ES4 GDSC1; GDSC2 6.177 8.4884 2.5585 0.6539
ES7 GDSC1; GDSC2 6.2911 8.8283 2.4782 0.8239
G-292 clone A141B1 GDSC1; GDSC2 6.2946 8.7914 2.4935 0.7766
NY GDSC1; GDSC2 6.6112 9.2724 2.443 0.7515
EW-3 GDSC1; GDSC2 6.6475 9.1351 2.5076 0.5664
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 168 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC1; GDSC2 5.8623 7.778 2.6943 0.4464
EoL-1 GDSC1; GDSC2 -8.9855 -3.2056 -9.0339 90.4154
Kasumi-1 GDSC2 -1.6184 0.5945 -1.6332 49.583
GDM-1 GDSC1; GDSC2 -0.7481 5.1113 -1.7107 42.1465
MHH-CALL-2 GDSC1 1.9664 5.408 -0.4598 8.3843
WSU-NHL GDSC1 2.4274 4.542 0.2295 2.4595
ST486 GDSC1 2.6691 6.8737 -0.6896 8.2019
CMK GDSC1 2.8262 4.2125 0.5455 0.4246
RC-K8 GDSC1 2.8938 4.4695 0.4778 0.6174
SUP-HD1 GDSC1; GDSC2 3.1535 6.2987 1.6909 10.4413
EHEB GDSC1 3.1625 5.131 0.3398 0.9595
SUP-B8 GDSC1; GDSC2 3.1767 5.1746 2.272 6.8374
P12-Ichikawa GDSC1 3.2125 4.4039 0.6196 0.1136
MOLM-13 GDSC1; GDSC2 3.4058 7.0862 1.5092 10.8149
Sc-1 GDSC1 3.4119 4.9324 0.5098 0.2611
TALL-1 [Human adult T-ALL] GDSC2 3.6231 9.1076 0.6761 15.4906
JURL-MK1 GDSC1; GDSC2 3.6739 5.7245 2.3999 4.7215
ARH-77 GDSC1; GDSC2 3.6751 7.1077 1.7147 8.8604
SUP-M2 GDSC1; GDSC2 3.7698 6.2686 2.2031 5.6792
JVM-2 GDSC1; GDSC2 3.7726 7.7108 1.4908 9.9475
MOLT-13 GDSC1; GDSC2 3.8238 8.0071 1.3833 10.4515
WSU-DLCL2 GDSC1; GDSC2 3.918 5.2383 2.8032 1.8361
SU-DHL-5 GDSC1; GDSC2 4.0055 6.2886 2.3624 4.2014
SCC-3 GDSC2 4.0309 7.415 1.832 7.5464
RPMI-8866 GDSC1; GDSC2 4.0391 6.6978 2.1879 5.1576
KE-37 GDSC1; GDSC2 4.0492 7.4554 1.8256 7.2843
SKM-1 GDSC1; GDSC2 4.0522 6.4028 2.3394 4.2387
TK [Human B-cell lymphoma] GDSC1; GDSC2 4.0534 6.2364 2.42 3.7665
P30/OHK GDSC1; GDSC2 4.0591 7.3282 1.895 6.8499
SU-DHL-6 GDSC1; GDSC2 4.0673 5.6994 2.682 2.2479
OCI-AML-5 GDSC1; GDSC2 4.0906 6.7926 2.1779 5.1056
HL-60 GDSC1; GDSC2 4.112 7.0294 2.0782 5.6473
P32/ISH GDSC1; GDSC2 4.1595 6.2893 2.4647 3.3025
SR GDSC1; GDSC2 4.1853 6.7536 2.2613 4.4218
Raji GDSC1; GDSC2 4.1937 8.1487 1.5908 8.3366
Jurkat GDSC1; GDSC2 4.2346 7.6867 1.8455 6.7506
BONNA-12 GDSC2 4.2357 8.3432 1.5261 8.9175
JeKo-1 GDSC1; GDSC2 4.2625 5.8547 2.7269 1.6949
Hs 445 GDSC2 4.3342 7.3033 2.0985 5.2459
P31/FUJ GDSC1; GDSC2 4.3386 5.6657 2.8496 0.9971
MV4-11 GDSC1; GDSC2 4.3505 12.0912 -0.2377 17.7026
SU-DHL-16 GDSC1; GDSC2 4.4019 5.8506 2.8038 1.1347
KMOE-2 GDSC1; GDSC2 4.4246 9.5964 1.0495 10.9074
EM-2 GDSC1; GDSC2 4.4379 7.3094 2.1639 4.4888
PF-382 GDSC1; GDSC2 4.4681 7.92 1.8937 5.9787
RPMI-8402 GDSC1; GDSC2 4.4954 6.2619 2.6763 1.6273
Jiyoye GDSC1; GDSC2 4.5476 7.8454 1.9819 5.3151
KCL-22 GDSC1; GDSC2 4.5551 6.5736 2.5724 2.0657
KG-1 GDSC1; GDSC2 4.5623 7.6659 2.0762 4.7515
Karpas-45 GDSC1; GDSC2 4.5742 6.367 2.6729 1.5426
BC-1 GDSC1; GDSC2 4.5969 6.3932 2.6735 1.5114
MC116 GDSC1; GDSC2 4.6006 5.7294 2.9449 0.3969
KOPN-8 GDSC1; GDSC2 4.6012 7.0231 2.3975 2.9101
GA-10 GDSC1; GDSC2 4.6529 6.4381 2.6834 1.398
SU-DHL-1 GDSC2 4.677 6.3767 2.7214 1.2418
NU-DUL-1 GDSC1; GDSC2 4.68 6.0699 2.8475 0.6774
NK-92MI GDSC2 4.7033 6.5074 2.6798 1.4051
JJN-3 GDSC1; GDSC2 4.7204 9.5423 1.286 8.9224
GR-ST GDSC1; GDSC2 4.7347 7.0171 2.4765 2.2989
MY-M12 GDSC1; GDSC2 4.7392 6.8051 2.5714 1.8226
DG-75 GDSC1; GDSC2 4.76 11.2052 0.5051 13.0659
SUP-B15 GDSC1; GDSC2 4.7657 6.7219 2.621 1.555
L-1236 GDSC1; GDSC2 4.8371 7.2908 2.4126 2.4787
A3/Kawakami GDSC1; GDSC2 4.8447 6.0229 2.9348 0.295
DND-41 GDSC1; GDSC2 4.8594 6.8576 2.6114 1.491
NB4 GDSC1; GDSC2 4.8948 5.9801 2.9694 0.1942
697 GDSC1; GDSC2 4.8993 6.8394 2.6389 1.325
AMO1 GDSC1; GDSC2 4.9163 6.0939 2.9369 0.2586
ALL-SIL GDSC1; GDSC2 4.9298 6.4906 2.7935 0.6809
SIG-M5 GDSC2 4.9427 5.8698 3.025 0.0899
U-698-M GDSC1; GDSC2 4.9485 7.807 2.2461 3.1731
KMS-11 GDSC1; GDSC2 4.9558 8.0236 2.1528 3.6531
KMS-12-BM GDSC2 4.9951 6.3775 2.8642 0.427
SU-DHL-10 GDSC1; GDSC2 5.0184 6.0579 2.9875 0.1253
DoHH2 GDSC1; GDSC2 5.0307 6.4315 2.8586 0.4094
BL-41 GDSC1; GDSC2 5.0465 6.56 2.8169 0.5246
HT GDSC1; GDSC2 5.0491 6.3707 2.8882 0.3209
Karpas-1106P GDSC1; GDSC2 5.07 7.3302 2.5189 1.673
JVM-3 GDSC1; GDSC2 5.0702 6.9782 2.6639 1.0545
HEL GDSC1; GDSC2 5.0857 6.9459 2.684 0.9624
ME1 GDSC1; GDSC2 5.0933 6.2971 2.9315 0.2052
TUR GDSC1; GDSC2 5.0986 6.8032 2.7459 0.725
OCI-M1 GDSC1; GDSC2 5.117 6.2221 2.9663 0.1354
Karpas-231 GDSC1; GDSC2 5.122 6.3708 2.9161 0.2272
QIMR-WIL GDSC1; GDSC2 5.1276 7.6432 2.4158 2.0825
Reh GDSC1; GDSC2 5.1557 7.0114 2.6897 0.8835
HC-1 GDSC1; GDSC2 5.1837 7.3067 2.5843 1.2724
Karpas-620 GDSC1; GDSC2 5.1859 6.8934 2.7488 0.6546
OCI-Ly7 GDSC1; GDSC2 5.2004 6.5897 2.8676 0.3063
ML-2 GDSC1; GDSC2 5.2044 6.7798 2.7994 0.4856
Ramos.2G6.4C10 GDSC1; GDSC2 5.2306 6.4614 2.9245 0.1768
RL GDSC1; GDSC2 5.2421 6.5257 2.9062 0.2076
L-428 GDSC1; GDSC2 5.2649 6.9726 2.7519 0.5941
OCI-AML-2 GDSC1; GDSC2 5.2689 6.396 2.9606 0.1105
THP-1 GDSC1; GDSC2 5.319 6.9091 2.7978 0.4304
Karpas-422 GDSC1; GDSC2 5.3402 6.9504 2.791 0.4381
NOMO-1 GDSC1; GDSC2 5.3451 6.7677 2.8591 0.2698
MOLP-8 GDSC1; GDSC2 5.3469 6.9782 2.7834 0.4556
OPM-2 GDSC1; GDSC2 5.3572 6.657 2.9025 0.1808
Farage GDSC1; GDSC2 5.3581 6.8878 2.8209 0.3526
KY821 GDSC1; GDSC2 5.3678 6.8846 2.8259 0.3366
U266B1 GDSC1; GDSC2 5.3688 6.8768 2.829 0.3287
HDLM-2 GDSC1; GDSC2 5.3764 7.4566 2.6131 0.9917
BC-3 GDSC2 5.385 6.8649 2.8395 0.3088
VAL GDSC1; GDSC2 5.3879 7.4139 2.635 0.9032
SU-DHL-8 GDSC1; GDSC2 5.3938 6.6865 2.9055 0.166
SU-DHL-4 GDSC1; GDSC2 5.4026 6.9204 2.8263 0.3213
L-363 GDSC1; GDSC2 5.4097 6.6801 2.9134 0.1494
RS4;11 GDSC1; GDSC2 5.4175 7.5833 2.5816 1.0764
MOLM-16 GDSC1; GDSC2 5.4209 6.9038 2.8393 0.2852
ALL-PO GDSC1; GDSC2 5.4236 12.1981 0.4897 11.7
OCI-AML-3 GDSC1; GDSC2 5.424 6.8215 2.8695 0.2221
IM-9 GDSC1; GDSC2 5.4267 6.8007 2.8778 0.2056
Karpas-299 GDSC1; GDSC2 5.4334 16.3091 -1.507 20.3535
ATN-1 GDSC1; GDSC2 5.4572 7.1579 2.7613 0.4608
BE-13 GDSC1; GDSC2 5.4704 7.2003 2.7509 0.4823
OCI-Ly19 GDSC1; GDSC2 5.4797 7.2902 2.7213 0.5618
KM-H2 GDSC1; GDSC2 5.4808 10.4491 1.3567 7.0455
NCI-H929 GDSC1; GDSC2 5.4873 7.3172 2.7143 0.5781
Daudi GDSC1; GDSC2 5.488 6.9089 2.8624 0.2162
EJM GDSC1; GDSC2 5.51 7.2625 2.7438 0.4819
DB GDSC1; GDSC2 5.5132 7.3309 2.7198 0.5478
CTV-1 GDSC1; GDSC2 5.5377 8.7137 2.1718 2.7354
SUP-T1 GDSC1; GDSC2 5.544 7.0271 2.8416 0.2387
SK-MM-2 GDSC1; GDSC2 5.568 7.2413 2.7744 0.3766
BV-173 GDSC1; GDSC2 5.5721 16.6081 -1.5519 20.212
CESS GDSC1; GDSC2 5.5752 7.0848 2.8329 0.246
MM1.S GDSC1; GDSC2 5.577 7.0732 2.8376 0.2362
Namalwa GDSC1; GDSC2 5.5781 6.9434 2.883 0.1574
CML-T1 GDSC1; GDSC2 5.5815 6.9525 2.8811 0.1596
MOLT-4 GDSC1; GDSC2 5.5838 8.23 2.3984 1.6597
NALM-6 GDSC1; GDSC2 5.5955 7.2591 2.7785 0.3555
Mono-Mac-6 GDSC1; GDSC2 5.5973 8.6918 2.2123 2.4719
Loucy GDSC1; GDSC2 5.5974 7.0473 2.8542 0.2001
CRO-AP2 GDSC1; GDSC2 5.6041 7.2803 2.7743 0.362
L-540 GDSC1; GDSC2 5.6159 7.287 2.7763 0.3524
MLMA GDSC1; GDSC2 5.6183 13.5197 -0.0132 13.7441
WIL2 NS GDSC1; GDSC2 5.639 7.0257 2.8765 0.1537
CA46 GDSC1; GDSC2 5.6696 7.7944 2.6099 0.7923
RPMI-8226 GDSC1; GDSC2 5.6734 7.7717 2.6201 0.7568
YT GDSC1; GDSC2 5.6904 7.1552 2.8503 0.1824
A4/Fukuda GDSC1; GDSC2 5.7226 7.9019 2.5913 0.8181
LP-1 GDSC1; GDSC2 5.7689 7.4415 2.7791 0.2905
EB2 GDSC1; GDSC2 5.7692 7.2532 2.8448 0.1723
K-562 GDSC1; GDSC2 5.7747 7.337 2.8179 0.2153
LAMA-84 GDSC1; GDSC2 5.7877 7.5609 2.7438 0.3599
MHH-PREB-1 GDSC1; GDSC2 5.7879 7.4973 2.7665 0.3102
RPMI-6666 GDSC1; GDSC2 5.8056 7.1665 2.887 0.1078
Granta-519 GDSC1; GDSC2 5.8063 7.452 2.7893 0.2585
BALL-1 GDSC1; GDSC2 5.8241 16.9429 -1.5326 19.6023
CCRF-CEM GDSC1; GDSC2 5.8285 7.479 2.788 0.2542
MOLT-16 GDSC1; GDSC2 5.9147 7.5047 2.8104 0.1922
MEG-01 GDSC1; GDSC2 5.9361 7.9595 2.6571 0.5072
CTB-1 GDSC1; GDSC2 6.0186 8.4911 2.4918 0.9499
H9 GDSC1; GDSC2 6.0238 16.0613 -0.9607 17.0101
RCH-ACV GDSC1; GDSC2 6.0518 7.7295 2.7821 0.2043
HH [Human lymphoma] GDSC1; GDSC2 6.0537 7.9982 2.6885 0.3827
NKM-1 GDSC1; GDSC2 6.0732 8.5485 2.4931 0.9101
ROS-50 GDSC1; GDSC2 6.076 7.824 2.7581 0.2381
Ku812 GDSC1; GDSC2 6.1001 7.897 2.7415 0.2608
JSC-1 GDSC1; GDSC2 6.1162 7.9032 2.7452 0.2497
VL51 GDSC1; GDSC2 6.1728 7.9383 2.7535 0.2209
MHH-CALL-4 GDSC2 6.1778 7.9914 2.7369 0.2563
LC4-1 GDSC1; GDSC2 6.2897 8.2277 2.6954 0.2904
PL-21 GDSC1; GDSC2 6.2951 8.3545 2.6528 0.3728
HAL-01 GDSC1; GDSC2 6.3442 8.2865 2.6948 0.276
MN-60 GDSC1; GDSC2 6.4835 8.2598 2.7535 0.1553
DEL GDSC1; GDSC2 6.5615 15.7933 -0.4645 13.8924
⏷ Show the Full List of 168 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ESO-26 GDSC1; GDSC2 4.3411 9.1342 1.2152 10.1668
OACM5.1 C GDSC1; GDSC2 4.9586 8.404 1.9807 4.5755
HCE-4 GDSC1; GDSC2 5.0391 9.1187 1.6991 5.9812
ESO-51 GDSC1; GDSC2 5.1809 7.9235 2.3234 2.4586
KYSE-50 GDSC1; GDSC2 5.4341 7.0374 2.7962 0.3807
KYSE-220 GDSC1; GDSC2 6.2185 7.9058 2.7809 0.1692
FLO-1 GDSC1; GDSC2 6.2584 11.1053 1.5192 4.9575
KYAE-1 GDSC1; GDSC2 6.3015 7.9865 2.7825 0.1511
SK-GT-4 GDSC1; GDSC2 6.4937 8.8761 2.5416 0.549
TE-12 GDSC1; GDSC2 6.8663 12.6224 1.1877 5.7076
OACP4 C GDSC1; GDSC2 8.4782 21.0895 -1.7202 15.3682
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1; GDSC2 4.9305 7.7329 2.2689 3.0813
Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CHP-134 GDSC1 2.7793 13.3375 -3.7559 24.1607
GOTO GDSC1; GDSC2 3.1695 11.4068 -0.8482 23.5874
SK-N-BE(2)-M17 GDSC1; GDSC2 3.78 11.1585 -0.2215 19.1205
IMR-5 GDSC1; GDSC2 4.1419 6.5166 2.3455 4.021
KP-N-RT-BM-1 GDSC2 4.1809 6.7401 2.2648 4.5678
NH-12 GDSC1; GDSC2 4.3867 8.1566 1.7241 7.1301
SK-N-MC-IXC GDSC1; GDSC2 4.488 5.8795 2.8346 0.9035
NB(TU)1 GDSC1; GDSC2 4.8012 6.6402 2.6732 1.2785
NB1 GDSC1; GDSC2 4.9376 6.2891 2.8737 0.4161
SJNB-12 GDSC1; GDSC2 5.0716 7.1139 2.6095 1.2759
CHP-212 GDSC1; GDSC2 5.1561 6.6971 2.8106 0.4797
SK-N-SH GDSC1; GDSC2 5.1602 7.0979 2.6574 1.0015
SJNB-7 GDSC1; GDSC2 5.1964 6.7074 2.8231 0.4226
SK-N-AS GDSC1; GDSC2 5.261 6.5076 2.9195 0.1773
SJNB-14 GDSC1; GDSC2 5.344 6.9801 2.7816 0.4622
SK-N-DZ GDSC1; GDSC2 5.4703 7.1492 2.7697 0.4321
CHP-126 GDSC1; GDSC2 5.4735 7.2359 2.739 0.5141
SJNB-6 GDSC1; GDSC2 5.4916 7.0676 2.8075 0.3295
SK-N-FI GDSC1; GDSC2 5.5733 7.1507 2.8089 0.2958
MHH-NB-11 GDSC1; GDSC2 5.6088 7.1385 2.8265 0.2479
SJNB-10 GDSC1; GDSC2 5.6446 7.2049 2.8164 0.2564
Kelly GDSC1; GDSC2 5.6757 7.1491 2.8472 0.1913
TGW GDSC1; GDSC2 5.7252 7.0584 2.8956 0.1109
LA-N-6 GDSC1; GDSC2 5.7698 7.3968 2.7952 0.2583
KP-N-YN GDSC1; GDSC2 5.8017 7.79 2.6659 0.5484
NB69 GDSC1; GDSC2 5.8196 7.9187 2.6254 0.6539
SiMa GDSC1; GDSC2 5.8487 8.1562 2.5477 0.8784
SJNB-13 GDSC1; GDSC2 5.9391 7.4884 2.8246 0.165
KP-N-YS GDSC1; GDSC2 6.0249 8.228 2.5936 0.6345
SJNB-17 GDSC1; GDSC2 6.0734 8.1715 2.6337 0.5045
GI-ME-N GDSC1; GDSC2 6.1949 9.0719 2.3433 1.34
SJNB-5 GDSC1; GDSC2 6.2285 7.9768 2.7602 0.1972
⏷ Show the Full List of 32 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC1; GDSC2 5.1315 6.7294 2.7882 0.5622
Cancer Drug Sensitivity Data Curated from 52 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCC202 GDSC1 2.0476 4.2862 0.1262 3.892
HCC38 GDSC1; GDSC2 4.279 6.928 2.2406 4.3558
HCC2157 GDSC1; GDSC2 4.3962 8.3879 1.6188 7.721
HCC1569 GDSC1; GDSC2 4.5182 6.9847 2.3654 3.2189
DU4475 GDSC1; GDSC2 4.9209 6.4043 2.8231 0.5854
BT-474 GDSC1; GDSC2 4.9493 6.3078 2.8715 0.416
CAL-148 GDSC2 5.0139 6.553 2.8058 0.6013
MRK-nu-1 GDSC1; GDSC2 5.1201 6.4171 2.8989 0.2657
MFM-223 GDSC1; GDSC2 5.1576 6.8936 2.7365 0.7152
OCUB-M GDSC1; GDSC2 5.1885 6.9195 2.7399 0.6825
HCC1187 GDSC1; GDSC2 5.231 6.9042 2.7637 0.578
CAL-120 GDSC1; GDSC2 5.2318 6.6871 2.8445 0.3493
HDQ-P1 GDSC1; GDSC2 5.2407 6.8529 2.7869 0.5021
MDA-MB-468 GDSC1; GDSC2 5.2646 7.8197 2.4113 1.942
MDA-MB-175-VII GDSC1; GDSC2 5.2732 6.8319 2.8079 0.4256
HCC1806 GDSC1; GDSC2 5.3053 6.6802 2.8752 0.2495
EFM-19 GDSC1; GDSC2 5.323 7.6012 2.5306 1.3615
UACC-893 GDSC1; GDSC2 5.349 7.6587 2.5196 1.3822
HCC1395 GDSC1; GDSC2 5.4901 9.4346 1.8276 4.5313
UACC-812 GDSC2 5.499 7.0297 2.8239 0.3005
Evsa-T GDSC1; GDSC2 5.5144 6.9811 2.8469 0.2378
MDA-MB-157 GDSC1; GDSC2 5.5206 7.5109 2.6549 0.7425
HCC1954 GDSC1; GDSC2 5.5728 7.1982 2.7917 0.3339
ZR-75-30 GDSC1; GDSC2 5.5999 7.4315 2.7174 0.509
HCC1419 GDSC1; GDSC2 5.6148 20.7748 -3.5751 26.1845
HCC1428 GDSC1; GDSC2 5.661 12.2085 0.6443 10.4393
CAL-51 GDSC1; GDSC2 5.6803 7.3355 2.7835 0.3121
CAMA-1 GDSC1; GDSC2 5.6877 7.2377 2.8207 0.2348
HCC1500 GDSC1; GDSC2 5.7489 7.4088 2.7832 0.2888
BT-20 GDSC1; GDSC2 5.7569 7.0555 2.9075 0.0923
EFM-192A GDSC1; GDSC2 5.7571 7.4176 2.7832 0.2862
JIMT-1 GDSC1; GDSC2 5.7582 7.4946 2.7563 0.3431
MCF-7 GDSC1; GDSC2 5.7648 7.6419 2.7056 0.4612
COLO 824 GDSC1; GDSC2 5.8233 8.0954 2.5601 0.8543
HCC70 GDSC1; GDSC2 5.8309 7.6054 2.7442 0.3426
YMB-1-E GDSC2 5.8351 7.9359 2.6253 0.6688
MDA-MB-361 GDSC1; GDSC2 5.863 7.9095 2.6464 0.5711
MDA-MB-415 GDSC1; GDSC2 5.8663 7.5741 2.7686 0.28
HCC2218 GDSC1; GDSC2 5.8677 7.621 2.7526 0.3118
MDA-MB-453 GDSC1; GDSC2 5.8703 7.5915 2.7639 0.2878
Hs 578T GDSC1; GDSC2 5.8795 8.0247 2.6103 0.6649
HCC1599 GDSC2 5.9275 7.401 2.8502 0.1368
BT-483 GDSC1; GDSC2 5.9672 7.7328 2.7502 0.2842
BT-549 GDSC1; GDSC2 5.9805 7.8891 2.6997 0.3854
MDA-MB-330 GDSC1; GDSC2 6.0183 16.9982 -1.4201 18.7856
MDA-MB-231 GDSC1; GDSC2 6.0406 7.8034 2.7524 0.258
T-47D GDSC1; GDSC2 6.0466 8.3505 2.5568 0.7288
HCC1143 GDSC1; GDSC2 6.2389 8.4304 2.6042 0.5053
MDA-MB-436 GDSC1; GDSC2 6.4035 8.1816 2.7521 0.1721
HCC1937 GDSC1; GDSC2 6.4885 8.3704 2.7177 0.2032
AU565 GDSC1; GDSC2 6.5208 8.8716 2.5538 0.5085
CAL-85-1 GDSC1; GDSC2 6.7209 8.746 2.6716 0.2207
⏷ Show the Full List of 52 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 55 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U-87MG ATCC GDSC1 1.6977 3.7017 0.177 4.3551
YH-13 GDSC1; GDSC2 3.1892 13.756 -2.0061 27.6541
PFSK-1 GDSC1 3.9228 14.645 -3.5669 20.5283
42-MG-BA GDSC1; GDSC2 4.0023 13.1531 -1.0388 22.0293
CAS-1 GDSC1; GDSC2 4.3906 6.1668 2.6604 1.851
DK-MG GDSC1; GDSC2 4.5298 11.9553 -0.0341 16.3009
Hs 683 GDSC1; GDSC2 4.5965 6.6062 2.5809 1.9646
D-502MG GDSC1; GDSC2 4.7059 7.4189 2.2796 3.3744
D-247MG GDSC1; GDSC2 4.7412 9.0178 1.5523 7.3766
D283 Med GDSC1; GDSC2 4.7863 6.4344 2.7506 0.9647
ONS-76 GDSC1; GDSC2 4.8169 12.5412 -0.1089 15.9686
H4 GDSC1; GDSC2 4.8276 7.2515 2.4247 2.4308
DBTRG-05MG GDSC1; GDSC2 4.9087 8.9129 1.7124 6.1484
8-MG-BA GDSC1; GDSC2 5.0121 6.9249 2.6582 1.1309
LN-18 GDSC1; GDSC2 5.082 6.0569 3.0102 0.0806
NMC-G1 GDSC1; GDSC2 5.1148 6.5974 2.831 0.4433
SNB-75 GDSC1; GDSC2 5.1213 8.9492 1.829 5.1239
Becker GDSC1; GDSC2 5.1222 6.8827 2.7252 0.7803
D-263MG GDSC1; GDSC2 5.1233 6.7747 2.7675 0.6343
SW1783 GDSC1; GDSC2 5.2276 8.7717 1.9737 4.1739
SF295 GDSC1; GDSC2 5.2332 6.8142 2.7984 0.473
KNS-42 GDSC1; GDSC2 5.2632 6.7178 2.8456 0.3329
T98G GDSC1; GDSC2 5.3841 7.7652 2.4929 1.4592
SW1088 GDSC1; GDSC2 5.3844 8.668 2.109 3.2451
GB-1 GDSC1; GDSC2 5.425 6.9306 2.8312 0.3015
SF539 GDSC1; GDSC2 5.4443 10.026 1.5302 6.1807
D-245MG GDSC2 5.4664 8.4775 2.2357 2.6097
YKG-1 GDSC1; GDSC2 5.5263 6.7612 2.9268 0.1068
U-251MG GDSC1; GDSC2 5.5545 7.2162 2.7782 0.373
D-542MG GDSC1; GDSC2 5.7286 7.6813 2.6768 0.5556
Daoy GDSC1; GDSC2 5.7387 7.2147 2.8472 0.1758
SF126 GDSC1; GDSC2 5.74 7.3222 2.8104 0.2387
GI-1 GDSC1; GDSC2 5.7476 11.5905 0.9921 8.4862
MOG-G-UVW GDSC1; GDSC2 5.7493 8.0437 2.5483 0.9441
LNZTA3WT4 GDSC1; GDSC2 5.7511 7.2356 2.8444 0.1772
Onda 10 GDSC1; GDSC2 5.7638 7.6709 2.6947 0.49
D-566MG GDSC1; GDSC2 5.7664 7.5501 2.7395 0.378
LN-405 GDSC1; GDSC2 5.7686 12.9434 0.3657 11.6187
Onda 11 GDSC1; GDSC2 5.7697 7.7495 2.6681 0.5587
MOG-G-CCM GDSC1; GDSC2 5.7934 8.2352 2.4931 1.1058
LN-229 GDSC1; GDSC2 5.8019 7.3854 2.811 0.2201
U-118MG GDSC1; GDSC2 5.8312 7.4754 2.7903 0.2492
SK-MG-1 GDSC1; GDSC2 5.8699 7.3534 2.8462 0.1485
GaMG GDSC1; GDSC2 5.906 7.6663 2.7509 0.3024
A-172 GDSC1; GDSC2 5.9931 10.3339 1.7122 4.3772
KNS-81-FD GDSC1; GDSC2 6.0003 7.5711 2.818 0.1616
D-336MG GDSC1; GDSC2 6.0141 8.473 2.4969 0.9363
AM-38 GDSC1; GDSC2 6.0673 16.8699 -1.3228 18.3224
KS-1 [Human Krukenberg tumour] GDSC1; GDSC2 6.0803 8.5091 2.511 0.8486
SF268 GDSC1; GDSC2 6.1301 8.07 2.6918 0.3483
M059J GDSC1; GDSC2 6.1791 8.0152 2.7291 0.2609
KINGS-1 GDSC1; GDSC2 6.4311 8.5151 2.6468 0.3401
D-423MG GDSC1; GDSC2 6.4971 8.5734 2.6507 0.3126
D-392MG GDSC1; GDSC2 6.4985 8.9813 2.5052 0.6392
KALS-1 GDSC1; GDSC2 6.756 8.8967 2.6324 0.274
⏷ Show the Full List of 55 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ETK-1 GDSC1; GDSC2 4.1973 6.6312 2.3277 4.0145
TGBC1TKB GDSC1; GDSC2 5.6345 8.1221 2.466 1.3374
TGBC24TKB GDSC1; GDSC2 6.196 7.992 2.7433 0.2319
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
AN3-CA GDSC1; GDSC2 3.9091 8.6942 1.1081 11.8308
KLE GDSC1; GDSC2 4.8493 8.1329 2.0388 4.445
ESS-1 GDSC1; GDSC2 5.0669 6.6545 2.7895 0.5992
EN GDSC1; GDSC2 5.2761 7.1013 2.7075 0.7313
MFE-319 GDSC1; GDSC2 5.6006 7.1497 2.8195 0.2645
RL95-2 GDSC1; GDSC2 5.6761 7.2059 2.8276 0.2256
MFE-280 GDSC1; GDSC2 5.6991 8.2859 2.4302 1.4216
MFE-296 GDSC1; GDSC2 6.056 7.8611 2.7379 0.2804
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 33 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KTCTL-1M GDSC1; GDSC2 2.0972 35.1476 -13.6227 43.557
LB996-RCC GDSC1; GDSC2 4.2733 8.1115 1.6662 7.7154
A-498 GDSC1; GDSC2 5.0456 6.4393 2.8617 0.393
BFTC-909 GDSC1; GDSC2 5.0853 6.5811 2.825 0.477
KMRC-1 GDSC1; GDSC2 5.1528 6.7832 2.7768 0.5851
SN12C GDSC1; GDSC2 5.1822 6.7685 2.7946 0.5124
SW13 GDSC1; GDSC2 5.363 7.0084 2.7788 0.4602
CAL-54 GDSC1; GDSC2 5.3736 7.4869 2.5999 1.0432
OS-RC-2 GDSC1; GDSC2 5.4424 7.1521 2.7575 0.4786
KMRC-20 GDSC1; GDSC2 5.4444 7.0008 2.8135 0.3346
KTCTL-140 GDSC1; GDSC2 5.4606 7.8526 2.4936 1.3838
786-O GDSC1; GDSC2 5.4897 7.054 2.8117 0.3207
VMRC-RCZ GDSC1; GDSC2 5.5197 7.0562 2.8223 0.2862
BB65-RCC GDSC1; GDSC2 5.5239 8.9615 2.0569 3.3135
TK-10 GDSC1; GDSC2 5.5373 7.5739 2.6379 0.7872
RCC10RGB GDSC1; GDSC2 5.6143 7.0385 2.8632 0.1803
KTCTL-13 GDSC1; GDSC2 5.6184 7.7391 2.6092 0.8282
LB1047-RCC GDSC1; GDSC2 5.6697 16.6068 -1.48 19.7406
769-P GDSC1; GDSC2 5.6932 7.542 2.7139 0.4728
NCC010 GDSC1; GDSC2 5.7456 13.4228 0.1207 12.8489
ACHN GDSC1; GDSC2 5.8233 7.2903 2.8513 0.1509
A-704 GDSC1; GDSC2 5.9498 10.3627 1.6753 4.6236
KTCTL-195 GDSC1; GDSC2 5.9627 25.0084 -5.4069 29.4034
NCC021 GDSC1; GDSC2 5.9919 8.2784 2.5614 0.7465
VMRC-RCW GDSC1; GDSC2 6.0271 7.6886 2.7873 0.2019
LB2241-RCC GDSC1; GDSC2 6.039 8.2877 2.5772 0.6737
HA7-RCC GDSC1; GDSC2 6.1011 8.4898 2.527 0.7869
UO-31 GDSC1; GDSC2 6.1043 8.0034 2.7057 0.3283
Caki-1 GDSC1; GDSC2 6.1297 8.0823 2.6873 0.3579
SW156 GDSC1; GDSC2 6.3629 8.7513 2.5358 0.6231
KTCTL-26A GDSC1; GDSC2 6.5471 8.4857 2.699 0.2182
RXF 393L GDSC1; GDSC2 6.7691 9.1204 2.559 0.4057
KTCTL-21 GDSC1; GDSC2 6.802 8.9061 2.6456 0.2419
⏷ Show the Full List of 33 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 47 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-407 GDSC1; GDSC2 4.2435 6.8772 2.2413 4.4216
NCI-H716 GDSC1; GDSC2 4.2628 8.8532 1.2958 9.889
HT115 GDSC1; GDSC2 4.7243 6.2379 2.8009 0.8189
SW948 GDSC1; GDSC2 4.7413 6.2423 2.8069 0.7809
MDST8 GDSC1; GDSC2 4.8361 6.286 2.8321 0.614
LS411N GDSC1; GDSC2 4.8627 6.048 2.9327 0.2922
HCT 116 GDSC1; GDSC2 5.0312 6.6549 2.774 0.6756
COLO205 GDSC1; GDSC2 5.0683 6.6228 2.8022 0.5575
SNU-81 GDSC1; GDSC2 5.0732 6.7337 2.7617 0.6881
SW1463 GDSC1; GDSC2 5.1515 7.1112 2.6482 1.045
HT-55 GDSC1; GDSC2 5.1564 6.5921 2.8496 0.371
LS513 GDSC1; GDSC2 5.1883 6.6032 2.8581 0.3347
HCT 15 GDSC1; GDSC2 5.2315 6.7423 2.8242 0.4021
HT-29 GDSC1; GDSC2 5.2747 6.577 2.9002 0.209
NCI-H508 GDSC1; GDSC2 5.2819 6.855 2.8029 0.435
LS1034 GDSC1; GDSC2 5.3554 6.9325 2.8036 0.3975
GP5d GDSC1; GDSC2 5.4495 6.9717 2.8258 0.3043
SNU-283 GDSC2 5.4567 6.94 2.8399 0.2809
LoVo GDSC1; GDSC2 5.4656 7.5569 2.6134 0.9221
LS180 GDSC1; GDSC2 5.4915 7.0219 2.8238 0.2931
SW1116 GDSC1; GDSC2 5.5797 7.0581 2.8439 0.2235
SNU-C1 GDSC1; GDSC2 5.6199 7.1925 2.8116 0.2741
RKO GDSC1; GDSC2 5.6237 7.2818 2.7812 0.3381
SW48 GDSC1; GDSC2 5.7014 7.6248 2.6867 0.542
SK-CO-1 GDSC1; GDSC2 5.703 7.3791 2.7765 0.3189
KM12 GDSC1; GDSC2 5.7427 7.149 2.871 0.1396
SNU-175 GDSC2 5.7483 7.5187 2.7438 0.3886
COLO 320HSR GDSC1; GDSC2 5.7495 7.559 2.7298 0.4079
SNU-C5 GDSC1; GDSC2 5.7651 7.4993 2.7572 0.3385
SNU-61 GDSC1; GDSC2 5.7833 7.3587 2.8135 0.2207
C2BBe1 GDSC1; GDSC2 5.8008 7.6461 2.7181 0.4144
RCM-1 [Human ESC] GDSC1; GDSC2 5.8038 7.3225 2.8334 0.1822
NCI-H747 GDSC1; GDSC2 5.8337 7.7309 2.7002 0.4443
SW620 GDSC1; GDSC2 5.852 7.6827 2.7246 0.3785
CaR-1 GDSC1; GDSC2 5.8971 7.956 2.6429 0.5636
SW837 GDSC1; GDSC2 5.9177 7.6074 2.7758 0.2506
LS123 GDSC1; GDSC2 5.9409 7.5974 2.7878 0.223
COLO 678 GDSC1; GDSC2 5.9437 7.8516 2.6991 0.4011
CW-2 GDSC1; GDSC2 5.9765 7.56 2.8134 0.1734
SW1417 GDSC1; GDSC2 6.1707 7.8294 2.79 0.1661
SW626 GDSC1; GDSC2 6.1749 8.3424 2.6112 0.5158
CCK-81 GDSC1; GDSC2 6.1833 8.1734 2.6751 0.3649
HCC2998 GDSC1; GDSC2 6.2878 12.777 0.7781 8.6144
CL-11 GDSC1; GDSC2 6.4857 8.5048 2.6704 0.2802
SNU-C2B GDSC1; GDSC2 6.5086 8.5869 2.6502 0.3101
T84 GDSC1; GDSC2 6.6848 8.7099 2.6712 0.2294
DiFi GDSC1; GDSC2 7.5125 9.466 2.7017 0.077
⏷ Show the Full List of 47 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1; GDSC2 5.5347 7.2513 2.7577 0.433
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Hep 3B2.1-7 GDSC1; GDSC2 4.0982 17.3301 -3.0462 28.2244
JHH-6 GDSC1; GDSC2 4.5975 5.6839 2.9608 0.3499
JHH-1 GDSC1; GDSC2 4.7542 5.7821 2.9868 0.2073
SK-HEP-1 GDSC1; GDSC2 4.8215 6.1836 2.8652 0.5122
Hep-G2/C3A GDSC1; GDSC2 4.9858 6.4882 2.8186 0.5572
SNU-423 GDSC1; GDSC2 5.2354 12.6267 0.1517 13.7743
HuH-1 GDSC1; GDSC2 5.2476 6.7565 2.8254 0.3912
SNU-387 GDSC1; GDSC2 5.3542 7.5828 2.5527 1.243
Huh-7 GDSC1; GDSC2 5.402 6.7839 2.8746 0.2191
JHH-7 GDSC1; GDSC2 5.4609 7.0398 2.8058 0.3461
SNU-449 GDSC1; GDSC2 5.6666 7.4329 2.7433 0.4104
JHH-2 GDSC1; GDSC2 5.7581 8.2269 2.4806 1.1789
SNU-398 GDSC1; GDSC2 5.9432 7.6338 2.776 0.2431
HLE GDSC1; GDSC2 6.0559 7.9029 2.7232 0.309
JHH-4 GDSC1; GDSC2 6.3924 7.8525 2.858 0.0631
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 186 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H1703 GDSC1; GDSC2 -0.74 21.0747 -9.1314 47.2957
NCI-H1869 GDSC1 1.4148 3.1446 0.2507 4.5655
NCI-H1304 GDSC1 1.5824 4.0599 -0.0759 6.5873
NCI-H187 GDSC1 2.8362 4.0259 0.6156 0.2241
SK-LU-1 GDSC1 3.3113 5.8288 0.132 1.7869
BEN GDSC1; GDSC2 3.8118 5.7 2.5123 3.7316
NCI-H2170 GDSC1; GDSC2 3.8636 5.4355 2.6753 2.6658
NCI-H446 GDSC1; GDSC2 3.9368 5.8073 2.5468 3.265
CAL-12T GDSC1; GDSC2 3.9929 6.1304 2.4299 3.8319
NCI-H1341 GDSC1; GDSC2 4.1867 7.1834 2.0558 5.6191
NCI-H596 GDSC1; GDSC2 4.2056 6.0999 2.5821 2.5611
A-427 GDSC1; GDSC2 4.2751 8.2008 1.624 7.9581
HCC366 GDSC1; GDSC2 4.3426 6.2905 2.5773 2.3602
NCI-H1694 GDSC1; GDSC2 4.3742 6.9328 2.3001 3.8359
EPLC-272H GDSC1; GDSC2 4.3908 10.7761 0.4438 14.2576
NCI-H1770 GDSC1; GDSC2 4.4408 7.3039 2.1683 4.4581
SBC-5 GDSC1; GDSC2 4.4884 6.3989 2.6124 1.9563
NCI-H2030 GDSC1; GDSC2 4.5055 6.7247 2.4764 2.6404
A-549 GDSC1; GDSC2 4.5502 6.5087 2.5983 1.9411
NCI-H82 GDSC1; GDSC2 4.5906 7.946 1.9624 5.3433
NCI-H460 GDSC1; GDSC2 4.6369 6.1478 2.7963 0.918
IST-SL2 GDSC1; GDSC2 4.668 9.1666 1.4311 8.2152
DMS 273 GDSC1; GDSC2 4.6973 9.5661 1.2585 9.1266
NCI-H64 GDSC1; GDSC2 4.7022 8.2161 1.9073 5.4431
Lu-135 GDSC1; GDSC2 4.7265 8.7441 1.6731 6.7218
IST-SL1 GDSC1; GDSC2 4.7406 6.8925 2.5344 2.0017
Calu-6 GDSC1; GDSC2 4.8039 6.3842 2.779 0.8353
NCI-H2141 GDSC1; GDSC2 4.8284 6.4593 2.7602 0.8876
COR-L88 GDSC1; GDSC2 4.8351 6.8823 2.5885 1.6239
NCI-H250 GDSC2 4.8529 7.3142 2.411 2.5526
Lu-165 GDSC1; GDSC2 4.8546 6.2863 2.84 0.5738
COR-L32 GDSC2 4.8587 7.209 2.4604 2.289
NCI-H2081 GDSC1; GDSC2 4.8589 6.9229 2.5835 1.6191
LCLC-103H GDSC1; GDSC2 4.8918 6.127 2.9153 0.3239
CPC-N GDSC1; GDSC2 4.9281 7.6932 2.2853 2.9998
NCI-H1963 GDSC2 4.9332 7.5581 2.3481 2.766
NCI-H2066 GDSC1; GDSC2 4.9371 6.9813 2.5985 1.463
NCI-H2135 GDSC1; GDSC2 4.9636 6.6875 2.7311 0.8844
NCI-H2444 GDSC1; GDSC2 5.0131 6.0295 2.9953 0.1143
NCI-H226 GDSC1; GDSC2 5.0402 6.1673 2.9575 0.1714
NCI-H1650 GDSC1; GDSC2 5.0479 8.4231 2.0258 4.1834
NCI-H2122 GDSC1; GDSC2 5.0543 6.6297 2.7937 0.5938
NCI-H345 GDSC1; GDSC2 5.0803 5.9578 3.0426 0.0471
COR-L279 GDSC1; GDSC2 5.0807 6.59 2.8197 0.4954
NCI-H1838 GDSC1; GDSC2 5.0887 9.0416 1.7661 5.5237
NCI-H2369 GDSC1; GDSC2 5.0982 6.6005 2.823 0.4755
NCI-H720 GDSC1; GDSC2 5.119 12.6471 0.0589 14.4795
NCI-H2029 GDSC1; GDSC2 5.1746 6.6804 2.8243 0.4304
LK-2 GDSC1; GDSC2 5.1766 7.3443 2.5655 1.3575
NCI-H1755 GDSC1; GDSC2 5.1767 6.939 2.7272 0.7336
NCI-H1836 GDSC1; GDSC2 5.1985 6.7641 2.8029 0.4787
HARA [Human squamous cell lung carcinoma] GDSC1; GDSC2 5.2006 9.4524 1.645 5.9871
NCI-H2171 GDSC2 5.2024 6.5813 2.8715 0.307
NCI-H1436 GDSC1; GDSC2 5.2052 6.7793 2.7999 0.4837
NCI-H2110 GDSC1; GDSC2 5.2141 7.7145 2.4301 1.9141
NCI-H2009 GDSC1; GDSC2 5.2327 7.0692 2.7011 0.7841
SBC-1 GDSC1; GDSC2 5.2717 6.9138 2.7769 0.5143
NCI-H838 GDSC1; GDSC2 5.2816 6.6742 2.8684 0.2727
NCI-H1299 GDSC1; GDSC2 5.2885 7.2123 2.6699 0.8532
UMC-11 GDSC1; GDSC2 5.2926 7.7006 2.4751 1.6268
NCI-H1793 GDSC1; GDSC2 5.3165 6.9663 2.7756 0.4935
NCI-H441 GDSC1; GDSC2 5.3582 7.2663 2.6793 0.7703
VMRC-LCD GDSC1; GDSC2 5.3766 6.8207 2.8521 0.2734
NCI-H661 GDSC1; GDSC2 5.3776 7.5853 2.5626 1.1832
NCI-H1155 GDSC1; GDSC2 5.4054 7.4907 2.6127 0.9704
NCI-H196 GDSC1; GDSC2 5.4076 6.9294 2.825 0.3223
NCI-H292 GDSC1; GDSC2 5.414 6.9213 2.8304 0.3076
NCI-H1105 GDSC1; GDSC2 5.4152 7.1836 2.7348 0.5581
IA-LM GDSC1; GDSC2 5.4283 7.2373 2.72 0.5947
RERF-LC-KJ GDSC1; GDSC2 5.4293 7.3205 2.6889 0.6912
DMS 79 GDSC1; GDSC2 5.4387 7.2405 2.723 0.5797
COLO 668 GDSC1; GDSC2 5.4434 7.3382 2.6881 0.6849
HCC827 GDSC1; GDSC2 5.4493 7.4419 2.6509 0.8036
SHP-77 GDSC1; GDSC2 5.4503 6.8117 2.8826 0.1903
Lu-139 GDSC1; GDSC2 5.4576 7.4233 2.6616 0.7619
COR-L311 GDSC2 5.4668 7.3616 2.6891 0.6911
COR-L95 GDSC1; GDSC2 5.4679 7.0851 2.7921 0.3761
NCI-H1092 GDSC1; GDSC2 5.4873 7.3552 2.7 0.6208
EBC-1 GDSC1; GDSC2 5.5006 7.2217 2.7551 0.4562
NCI-H650 GDSC1; GDSC2 5.5161 7.1985 2.7697 0.4108
LOU-NH91 GDSC1; GDSC2 5.5211 7.2538 2.7515 0.4559
Ms-1 GDSC1; GDSC2 5.5274 7.3115 2.7327 0.5037
NCI-H1915 GDSC1; GDSC2 5.531 7.4178 2.6946 0.612
NCI-H841 GDSC1; GDSC2 5.5606 7.4057 2.7111 0.547
NCI-H2803 GDSC2 5.566 7.0373 2.8462 0.2314
NCI-H526 GDSC1; GDSC2 5.5703 13.4078 0.0076 13.7467
NCI-H2196 GDSC2 5.5931 7.0184 2.8626 0.1935
NCI-H211 GDSC1; GDSC2 5.6065 7.6216 2.649 0.7069
NCI-H209 GDSC1; GDSC2 5.6106 7.7318 2.6087 0.8353
NCI-H847 GDSC1; GDSC2 5.6131 7.2046 2.8047 0.2907
HCC33 GDSC2 5.6261 7.2014 2.8107 0.2836
SBC-3 GDSC1; GDSC2 5.6317 7.5507 2.6861 0.5806
NCI-H524 GDSC1; GDSC2 5.6406 7.4001 2.745 0.4174
NCI-H1792 GDSC1; GDSC2 5.6435 7.5802 2.6799 0.5921
Lu-65 GDSC1; GDSC2 5.6595 7.5266 2.7062 0.5097
NCI-H2085 GDSC1; GDSC2 5.6597 7.8748 2.5747 0.9166
NCI-H1573 GDSC1; GDSC2 5.661 7.5983 2.6803 0.5815
NCI-H290 GDSC1; GDSC2 5.6814 7.3016 2.7959 0.2854
RERF-LC-MS GDSC1; GDSC2 5.6842 7.4447 2.7458 0.3966
COR-L321 GDSC1; GDSC2 5.6851 7.0371 2.8889 0.1267
NCI-H2795 GDSC1; GDSC2 5.7005 7.4945 2.7341 0.4183
EMC-BAC-2 GDSC1; GDSC2 5.7168 7.9727 2.5616 0.9212
NCI-H2810 GDSC1; GDSC2 5.7256 7.9754 2.5644 0.9057
LB647-SCLC GDSC1; GDSC2 5.732 7.4822 2.7507 0.3656
NCI-H1876 GDSC1; GDSC2 5.744 7.6577 2.6916 0.5075
Lu-99A GDSC1; GDSC2 5.7504 7.7306 2.6673 0.571
NCI-H23 GDSC1; GDSC2 5.7629 7.8868 2.614 0.721
COR-L303 GDSC2 5.7756 7.262 2.8441 0.1782
NCI-H1975 GDSC1; GDSC2 5.7891 7.4216 2.7936 0.2555
NCI-H358 GDSC1; GDSC2 5.7983 7.6934 2.7 0.4603
NCI-H1781 GDSC1; GDSC2 5.8097 7.4295 2.7984 0.2404
NCI-H1435 GDSC1; GDSC2 5.8169 7.3148 2.8407 0.1678
NCI-H835 GDSC1; GDSC2 5.8201 7.8731 2.6426 0.604
NCI-H1581 GDSC1; GDSC2 5.8407 7.4522 2.8018 0.2255
NCI-H1993 GDSC1; GDSC2 5.8438 7.4318 2.81 0.2105
NCI-H2172 GDSC1; GDSC2 5.8452 7.3695 2.832 0.1747
NCI-H522 GDSC1; GDSC2 5.8464 7.763 2.6935 0.4552
NCI-H1437 GDSC1; GDSC2 5.8557 7.7076 2.7171 0.3944
NCI-H810 GDSC1; GDSC2 5.8565 7.3826 2.8315 0.1728
NCI-H1734 GDSC2 5.8692 7.8269 2.6792 0.4984
NCI-H2087 GDSC1; GDSC2 5.8806 8.1468 2.5647 0.803
NCI-H1623 GDSC1; GDSC2 5.8808 7.7385 2.7157 0.3877
PC-14 GDSC1; GDSC2 5.8815 7.9064 2.655 0.5386
DMS 53 GDSC1; GDSC2 5.8836 8.0425 2.6053 0.6773
NCI-H513 GDSC1; GDSC2 5.8843 7.857 2.6741 0.4873
NCI-H1666 GDSC1; GDSC2 5.8844 7.4411 2.8214 0.182
NCI-H2227 GDSC1; GDSC2 5.8911 7.4436 2.8229 0.1781
NCI-H2405 GDSC1; GDSC2 5.8985 7.9449 2.6475 0.5503
NCI-H146 GDSC1; GDSC2 5.9003 7.6295 2.7617 0.2827
NCI-H748 GDSC2 5.9201 8.0668 2.6111 0.6633
NCI-H727 GDSC1; GDSC2 5.925 7.6824 2.7522 0.2935
NCI-H2722 GDSC1; GDSC2 5.9272 7.5968 2.783 0.235
NCI-H1693 GDSC1; GDSC2 5.9296 7.8111 2.7083 0.3856
NCI-H1048 GDSC1; GDSC2 5.9319 7.4128 2.8478 0.1345
HOP-62 GDSC1; GDSC2 5.9334 7.5575 2.7989 0.2062
NCI-H1355 GDSC1; GDSC2 5.9336 8.1897 2.5706 0.7525
HOP-92 GDSC1; GDSC2 5.9396 8.4663 2.4673 1.0887
NCI-H647 GDSC1; GDSC2 5.9592 7.8503 2.7055 0.3805
DMS 114 GDSC1; GDSC2 5.9615 8.1748 2.5877 0.6855
NCI-H1648 GDSC1; GDSC2 5.9766 8.1547 2.6013 0.638
SK-MES-1 GDSC1; GDSC2 5.9845 7.6352 2.7904 0.2074
HCC78 GDSC1; GDSC2 5.9865 7.916 2.6924 0.3998
NCI-H2342 GDSC1; GDSC2 5.9869 8.0824 2.6322 0.5484
ChaGo-K-1 GDSC1; GDSC2 5.9991 7.865 2.7153 0.3444
LCLC-97TM1 GDSC1; GDSC2 6.0178 8.3936 2.5287 0.8317
NCI-H2804 GDSC1; GDSC2 6.0231 8.895 2.3357 1.5091
EMC-BAC-1 GDSC1; GDSC2 6.0313 8.7736 2.3876 1.3058
LXF 289 GDSC1; GDSC2 6.038 18.1716 -1.979 20.706
KNS-62 GDSC1; GDSC2 6.0414 7.4864 2.8608 0.1011
Calu-3 GDSC1; GDSC2 6.053 7.6533 2.8086 0.1641
ABC-1 GDSC1; GDSC2 6.0636 8.4891 2.5117 0.857
NCI-H2228 GDSC1; GDSC2 6.0839 8.2189 2.6205 0.5333
NCI-H3255 GDSC1; GDSC2 6.1039 7.8167 2.7707 0.2099
NCI-H3122 GDSC1; GDSC2 6.1067 8.3298 2.5889 0.6059
NCI-H2023 GDSC1; GDSC2 6.1108 8.0101 2.7058 0.3261
NCI-H1568 GDSC1; GDSC2 6.1172 8.2167 2.6343 0.4837
PaCa-3 GDSC1; GDSC2 6.1324 8.2773 2.6182 0.517
NCI-H69 GDSC1; GDSC2 6.1383 7.9554 2.7351 0.2616
HCC15 GDSC1; GDSC2 6.1437 8.0158 2.7159 0.2956
LC-2/ad GDSC1; GDSC2 6.17 7.9933 2.7334 0.2557
HCC44 GDSC1; GDSC2 6.1786 8.1476 2.6825 0.3511
NCI-H2291 GDSC1; GDSC2 6.1822 7.7796 2.8109 0.1364
NCI-H2591 GDSC1; GDSC2 6.2164 8.0209 2.7406 0.2311
NCI-H1651 GDSC1; GDSC2 6.2257 8.304 2.6446 0.4159
LC-1/sq GDSC1; GDSC2 6.2558 8.5175 2.5791 0.5605
SW1573 GDSC1; GDSC2 6.2637 8.2382 2.6822 0.3236
SW1271 GDSC1; GDSC2 6.2679 8.2902 2.6654 0.356
NCI-H510A GDSC1; GDSC2 6.3217 7.7065 2.8824 0.0521
NCI-H2818 GDSC1; GDSC2 6.351 8.1514 2.7438 0.1946
EKVX GDSC1; GDSC2 6.3536 8.8895 2.481 0.7805
NCI-H322M GDSC1; GDSC2 6.386 8.3817 2.6769 0.2965
NCI-H2731 GDSC1; GDSC2 6.393 8.6099 2.5988 0.4551
NCI-H2595 GDSC1; GDSC2 6.409 8.3019 2.7129 0.2288
NCI-H2869 GDSC1; GDSC2 6.4692 8.6304 2.6203 0.3808
COR-L105 GDSC1; GDSC2 6.4849 8.3897 2.7098 0.2158
NCI-H2461 GDSC1; GDSC2 6.5046 8.5105 2.6753 0.2667
NCI-H520 GDSC1; GDSC2 6.5164 8.3001 2.7513 0.1522
NCI-H2347 GDSC1; GDSC2 6.5652 8.3903 2.7378 0.1606
Lu-134-A GDSC1; GDSC2 6.6501 8.957 2.5724 0.4185
NCI-H740 GDSC2 6.75 8.6231 2.7234 0.152
RERF-LC-Sq1 GDSC1; GDSC2 6.7557 14.9496 0.0599 11.2176
NCI-H1944 GDSC1; GDSC2 6.76 8.935 2.6206 0.2929
COR-L23 GDSC1; GDSC2 7.6193 21.4048 -2.4372 19.1692
NCI-H2373 GDSC1; GDSC2 7.9254 25.7596 -4.3304 23.7235
NCI-H1563 GDSC1; GDSC2 8.1952 24.3597 -3.4648 21.1304
NCI-H1688 GDSC1; GDSC2 8.9033 21.472 -1.6307 14.3905
⏷ Show the Full List of 186 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1; GDSC2 5.8897 7.6308 2.7573 0.2948
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OE19 GDSC1; GDSC2 4.9378 6.7871 2.679 1.1158
KYSE-180 GDSC1; GDSC2 4.9473 6.5881 2.7631 0.7773
KYSE-150 GDSC1; GDSC2 5.1456 6.4238 2.9062 0.24
EC-GI-10 GDSC1; GDSC2 5.1561 7.4704 2.5034 1.6479
TE-5 GDSC1; GDSC2 5.3988 7.1029 2.7581 0.4994
TE-9 GDSC1; GDSC2 5.4922 6.9869 2.8366 0.2658
KYSE-410 GDSC1; GDSC2 5.5469 7.3941 2.7099 0.5579
TE-11 GDSC1; GDSC2 5.5535 7.579 2.6429 0.7602
T.T GDSC1; GDSC2 5.5849 7.4419 2.7076 0.5443
KYSE-70 GDSC1; GDSC2 5.5906 7.1753 2.8067 0.2944
KYSE-450 GDSC1; GDSC2 5.6065 7.0551 2.8547 0.1966
KYSE-510 GDSC1; GDSC2 5.6851 7.0246 2.8931 0.1212
COLO 680N GDSC1; GDSC2 5.7125 7.244 2.8276 0.2153
OE33 GDSC1; GDSC2 5.7521 7.6057 2.7139 0.4461
TE-1 GDSC1; GDSC2 5.7942 7.7596 2.6742 0.5298
KYSE-270 GDSC1; GDSC2 5.8166 7.6627 2.7182 0.4076
TE-10 GDSC1; GDSC2 5.8232 7.4225 2.8058 0.2234
OE21 GDSC1; GDSC2 5.8296 9.1089 2.1545 2.4681
TE-8 GDSC1; GDSC2 5.8943 7.8605 2.6768 0.476
TE-4 GDSC1; GDSC2 5.9678 7.5086 2.8279 0.1543
TE-15 GDSC1; GDSC2 6.037 8.3615 2.5487 0.7585
TE-6 GDSC1; GDSC2 6.1155 7.972 2.7209 0.2947
KYSE-520 GDSC1; GDSC2 6.2279 8.3481 2.6296 0.4491
KYSE-140 GDSC1; GDSC2 6.9563 9.0711 2.6438 0.2112
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OAW28 GDSC1; GDSC2 1.7972 7.3911 -0.0903 24.805
OAW42 GDSC1 2.323 3.4966 0.6078 0.5387
OV56 GDSC1; GDSC2 4.5247 12.2201 -0.1689 16.9503
TYK-nu GDSC1; GDSC2 4.8102 6.871 2.5805 1.6911
OVISE GDSC1; GDSC2 4.8528 10.7144 0.8107 11.2464
OVTOKO GDSC1; GDSC2 4.9269 11.3319 0.5629 12.3893
SK-OV-3 GDSC1; GDSC2 5.0431 9.0079 1.7533 5.6752
JHOS-2 GDSC1; GDSC2 5.0738 9.2786 1.6463 6.2089
OVK18 GDSC1; GDSC2 5.1198 6.8666 2.7305 0.7635
OC 314 GDSC1; GDSC2 5.1884 9.4208 1.6521 5.9703
Caov-3 GDSC2 5.2485 6.7591 2.8248 0.4065
DOV13 GDSC1; GDSC2 5.321 6.9212 2.7941 0.4394
OVCAR-5 GDSC1; GDSC2 5.3694 10.394 1.3118 7.4892
OVKATE GDSC1; GDSC2 5.3952 6.9862 2.7997 0.3894
RMG-I GDSC1; GDSC2 5.4094 7.4893 2.615 0.9589
TOV-21G GDSC1; GDSC2 5.4464 6.8005 2.885 0.1871
ES-2 GDSC1; GDSC2 5.4618 7.0785 2.7921 0.3787
Kuramochi GDSC1; GDSC2 5.6519 7.8831 2.5682 0.9448
A2780 GDSC1; GDSC2 5.6945 7.2884 2.8054 0.262
EFO-27 GDSC1; GDSC2 5.7942 7.5909 2.7355 0.3762
Caov-4 GDSC1; GDSC2 5.8288 7.9142 2.6309 0.6329
EFO-21 GDSC1; GDSC2 5.948 7.9149 2.6779 0.4496
TOV-112D GDSC1; GDSC2 5.9491 7.8557 2.6997 0.3977
OVCAR-3 GDSC1; GDSC2 5.9834 7.7344 2.7555 0.269
OV-90 GDSC1; GDSC2 5.9871 7.6335 2.7919 0.2042
IGROV-1 GDSC1; GDSC2 6.001 7.8122 2.7347 0.3038
OVCAR-4 GDSC1; GDSC2 6.0235 8.0793 2.6477 0.4916
FU-OV-1 GDSC1; GDSC2 6.0438 7.6425 2.809 0.1654
OVCAR-8 GDSC1; GDSC2 6.1128 7.7979 2.7803 0.1927
JHOS-4 GDSC1; GDSC2 7.3294 17.7395 -0.8832 14.214
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Capan-2 GDSC1 3.1968 5.236 0.3142 1.0397
HPAF-II GDSC1 3.8339 5.7061 0.3942 0.3761
KP-1N GDSC1; GDSC2 4.3034 8.4337 1.5307 8.4382
HPAC GDSC1; GDSC2 4.3923 6.5723 2.4784 2.8131
DAN-G GDSC1; GDSC2 4.7473 6.352 2.7656 0.9397
YAPC GDSC1; GDSC2 4.7747 6.1427 2.8609 0.5582
SU.86.86 GDSC1; GDSC2 4.8699 6.4336 2.7893 0.7418
PaTu 8902 GDSC1; GDSC2 4.8928 6.2799 2.8586 0.4881
Panc 02.03 GDSC1; GDSC2 5.1373 12.4534 0.1664 13.9187
Panc 08.13 GDSC1; GDSC2 5.2345 7.0424 2.7123 0.7441
PaTu 8988t GDSC1; GDSC2 5.2415 6.6419 2.8647 0.2965
QGP-1 GDSC1; GDSC2 5.2585 7.0513 2.7192 0.7042
KP-4 GDSC1; GDSC2 5.2768 6.6927 2.8599 0.2935
CFPAC-1 GDSC1; GDSC2 5.2804 6.9748 2.7576 0.5673
Panc 03.27 GDSC1; GDSC2 5.2841 7.3086 2.63 1.0028
KP-2 GDSC1; GDSC2 5.3744 7.8244 2.4639 1.5912
MIA PaCa-2 GDSC1; GDSC2 5.3849 6.8174 2.8564 0.2614
SW1990 GDSC1; GDSC2 5.3882 7.3953 2.6424 0.8766
Capan-1 GDSC1; GDSC2 5.4877 7.0715 2.8047 0.3377
Panc 04.03 GDSC1; GDSC2 5.5455 7.4974 2.6706 0.6769
HuP-T4 GDSC1; GDSC2 5.7453 7.7366 2.663 0.5857
BxPC-3 GDSC1; GDSC2 5.8283 7.7082 2.7063 0.4314
Hs 766T GDSC1; GDSC2 5.8822 7.7131 2.7253 0.3654
PSN1 GDSC1; GDSC2 5.9022 7.6204 2.7656 0.2746
MZ-PC-1 GDSC1; GDSC2 5.9235 8.1121 2.5956 0.6836
AsPC-1 GDSC1; GDSC2 6.1163 8.1672 2.6518 0.4421
Panc 10.05 GDSC1; GDSC2 6.1361 7.783 2.7937 0.1681
HuP-T3 GDSC1; GDSC2 6.2125 7.9742 2.7553 0.2083
KP-3 GDSC1; GDSC2 6.3168 8.8385 2.485 0.7892
PL4 GDSC1; GDSC2 6.3321 8.1949 2.7222 0.2324
SUIT-2 GDSC1; GDSC2 6.9128 18.6425 -1.5917 17.6427
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H28 GDSC1; GDSC2 5.5004 7.1845 2.7686 0.4207
IST-Mes1 GDSC1; GDSC2 5.5959 7.5048 2.6886 0.5929
MPP 89 GDSC1; GDSC2 5.7861 7.5044 2.7633 0.3176
NCI-H2052 GDSC1; GDSC2 5.8916 7.5603 2.7827 0.2455
MSTO-211H GDSC1; GDSC2 6.008 7.7909 2.7448 0.2819
NCI-H2452 GDSC1; GDSC2 6.072 8.1031 2.6579 0.4459
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H660 GDSC2 4.8847 6.5289 2.7583 0.877
VCaP GDSC1; GDSC2 5.4704 7.2118 2.7467 0.4941
22Rv1 GDSC1; GDSC2 5.9346 7.9014 2.6776 0.4561
DU145 GDSC1; GDSC2 5.9566 7.7524 2.7393 0.3091
PC-3 GDSC1; GDSC2 5.9991 7.9548 2.6832 0.4159
LNCaP clone FGC GDSC1; GDSC2 6.0986 7.8091 2.7714 0.2101
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1; GDSC2 5.9663 7.7482 2.7444 0.2957
Cancer Drug Sensitivity Data Curated from 57 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Hs 940.T GDSC1; GDSC2 1.5442 17.3305 -5.2139 38.8895
M14 GDSC1 2.8678 4.4286 0.4825 0.6182
IPC-298 GDSC1; GDSC2 3.8762 6.712 2.0637 6.2651
SK-MEL-28 GDSC1; GDSC2 4.3082 5.5135 2.8981 0.8144
SK-MEL-2 GDSC1; GDSC2 4.3337 6.1611 2.6305 2.0909
RPMI-7951 GDSC1; GDSC2 4.5656 6.4087 2.6503 1.6628
A101D GDSC1; GDSC2 4.658 6.2181 2.7776 0.9754
A-431 GDSC1; GDSC2 4.8733 6.632 2.7115 1.043
UACC-257 GDSC1; GDSC2 4.8786 6.2155 2.8771 0.4397
IGR-37 GDSC1; GDSC2 4.8951 6.1807 2.8968 0.3728
WT2-iPS GDSC1; GDSC2 4.942 6.2813 2.8784 0.4001
CP66-MEL GDSC1; GDSC2 4.9546 6.3834 2.8453 0.4919
SK-MEL-24 GDSC1; GDSC2 4.9837 7.0878 2.5772 1.5068
A2058 GDSC1; GDSC2 5.0154 6.3573 2.8798 0.3586
A-388 GDSC1; GDSC2 5.0681 7.4031 2.4872 1.8201
G-361 GDSC1; GDSC2 5.0745 6.787 2.7416 0.7576
LB373-MEL-D GDSC1; GDSC2 5.092 6.2961 2.9313 0.206
COLO 783 GDSC1; GDSC2 5.117 6.3787 2.9114 0.2389
GAK GDSC1; GDSC2 5.1455 6.3705 2.925 0.2013
SK-MEL-5 GDSC1; GDSC2 5.1831 6.6289 2.8467 0.366
SK-MEL-30 GDSC1; GDSC2 5.1947 6.506 2.8955 0.2454
RVH-421 GDSC1; GDSC2 5.203 6.5543 2.8814 0.2733
LB2518-MEL GDSC1; GDSC2 5.2595 6.5998 2.8865 0.2417
COLO 829 GDSC1; GDSC2 5.2619 9.7767 1.5325 6.4902
UACC-62 GDSC1; GDSC2 5.2922 6.9877 2.7576 0.5603
IGR-1 GDSC1; GDSC2 5.3113 7.298 2.6465 0.9203
CHL-1 GDSC1; GDSC2 5.3298 7.0399 2.7535 0.5509
LOX-IMVI GDSC1; GDSC2 5.3457 6.8497 2.8299 0.3361
MeWo GDSC1; GDSC2 5.4076 6.8352 2.8586 0.249
VMRC-MELG GDSC2 5.4141 6.7364 2.8955 0.1839
WM1552C GDSC1; GDSC2 5.4243 7.0312 2.7947 0.3889
HT-144 GDSC1; GDSC2 5.4412 7.1851 2.7448 0.5148
SK-MEL-1 GDSC1; GDSC2 5.4557 6.6157 2.9514 0.0891
MZ-MEL-2 GDSC1; GDSC2 5.4558 14.9409 -0.8195 17.6449
WM278 GDSC1; GDSC2 5.4615 7.7405 2.5391 1.2021
WM115 GDSC1; GDSC2 5.4689 6.7734 2.9025 0.1526
MZ-MEL-7 GDSC1; GDSC2 5.4862 7.3466 2.7028 0.6131
DJM-1 GDSC1; GDSC2 5.5442 7.5047 2.6672 0.6881
CP50-MEL-B GDSC1; GDSC2 5.553 7.027 2.845 0.2296
SK-MEL-3 GDSC1; GDSC2 5.5651 6.9624 2.8719 0.1784
Mel Ho GDSC1; GDSC2 5.6339 7.1857 2.8191 0.2543
COLO 679 GDSC1; GDSC2 5.6351 7.0597 2.8635 0.1748
SK-MEL-31 GDSC1; GDSC2 5.6454 15.8752 -1.1394 18.5111
WM793 GDSC1; GDSC2 5.6495 6.9933 2.8912 0.1304
A-375 GDSC1; GDSC2 5.7604 7.632 2.7075 0.4583
MMAc-SF GDSC1; GDSC2 5.7792 7.4097 2.7941 0.2575
SH-4 GDSC1; GDSC2 5.8168 7.6932 2.7073 0.4339
Hs 938.T GDSC1; GDSC2 5.8536 7.3127 2.8543 0.1406
G-mel GDSC1; GDSC2 5.9723 7.5366 2.8199 0.1647
COLO 800 GDSC1; GDSC2 5.9923 7.5438 2.8245 0.1541
451Lu GDSC1; GDSC2 6.0207 8.0439 2.6594 0.4636
HMV-II GDSC1; GDSC2 6.0222 8.0255 2.6667 0.4455
Mel JuSo GDSC1; GDSC2 6.0737 18.8398 -2.2804 21.6112
WM35 GDSC1; GDSC2 6.1284 8.2223 2.6366 0.4733
IST-MEL1 GDSC1; GDSC2 6.2022 8.0645 2.7204 0.2701
COLO 792 GDSC1; GDSC2 6.3864 8.2303 2.7294 0.2082
EquiPSC Line K2 GDSC1; GDSC2 6.8404 8.9545 2.6427 0.2375
⏷ Show the Full List of 57 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1; GDSC2 4.4686 6.6102 2.5065 2.5382
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-204 GDSC1; GDSC2 -0.6056 3.981 -1.1608 39.9943
G-402 GDSC1; GDSC2 0.711 4.567 0.0568 28.5489
Rh18 GDSC1 2.2353 9.6385 -2.338 19.5436
SK-LMS-1 GDSC1; GDSC2 2.6373 8.8641 -0.0386 21.6465
MES-SA GDSC1; GDSC2 3.6818 5.4728 2.5297 3.9215
Rh41 GDSC1; GDSC2 4.5785 8.6401 1.6232 7.3076
SW684 GDSC1; GDSC2 4.71 5.7742 2.9726 0.2598
RKN GDSC1; GDSC2 4.9564 7.1208 2.5496 1.6622
VA-ES-BJ GDSC1; GDSC2 5.0809 6.842 2.7229 0.8201
KYM-1 GDSC1; GDSC2 5.0884 6.6837 2.7875 0.5918
MFH-ino GDSC1; GDSC2 5.1019 6.7812 2.7558 0.6882
SW982 GDSC1; GDSC2 5.2038 6.5258 2.8919 0.2499
HT-1080 GDSC1; GDSC2 5.2909 6.7895 2.8304 0.3585
SW872 GDSC1; GDSC2 5.3119 7.7518 2.4634 1.6578
TE 441.T GDSC2 5.5 6.7476 2.9222 0.1217
GCT GDSC1; GDSC2 5.5146 8.021 2.4507 1.5086
G-401 GDSC1; GDSC2 5.6348 7.8979 2.5549 1.0042
Rh30 GDSC1; GDSC2 5.7401 7.1965 2.8539 0.1651
Hs 633.T GDSC1; GDSC2 5.7871 7.1139 2.8983 0.0979
EW-8 GDSC1; GDSC2 5.8769 7.6273 2.7538 0.3061
SK-UT-1 GDSC1; GDSC2 5.9346 7.6198 2.7777 0.2424
RD GDSC1; GDSC2 5.9655 8.2259 2.5702 0.7352
STS-0421 GDSC1; GDSC2 7.0083 9.2547 2.5995 0.2655
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KATO III GDSC1; GDSC2 3.3152 7.1845 1.385 11.8099
SNU-16 GDSC1; GDSC2 3.3747 5.1295 2.4618 5.1114
NCI-N87 GDSC1 3.8164 6.353 0.1505 1.2053
HGC-27 GDSC1; GDSC2 3.9748 10.5982 0.2125 16.4952
MKN45 GDSC1; GDSC2 4.4719 5.5641 2.9534 0.4543
SCH GDSC1; GDSC2 4.5193 5.9062 2.8387 0.855
SNU-5 GDSC1; GDSC2 4.6367 12.5766 -0.2606 17.1024
ECC12 GDSC2 4.6437 6.4804 2.6607 1.5692
AGS GDSC1; GDSC2 5.2269 6.7306 2.8267 0.3978
GCIY GDSC1; GDSC2 5.2854 7.1389 2.6971 0.7606
OCUM-1 GDSC1; GDSC2 5.3213 8.3949 2.1941 2.9078
HSC-39 GDSC1; GDSC2 5.3699 6.9845 2.7903 0.4256
ECC10 GDSC1; GDSC2 5.392 6.9572 2.809 0.3674
NUGC-4 GDSC1; GDSC2 5.4675 7.3023 2.7117 0.5971
MKN1 GDSC1; GDSC2 5.4837 6.9799 2.8359 0.2701
MKN7 GDSC1; GDSC2 5.4925 7.4286 2.6744 0.6976
TMK-1 GDSC1; GDSC2 5.5365 8.0608 2.4449 1.5117
IM95 GDSC1; GDSC2 5.6694 7.6606 2.6604 0.6349
Fu97 GDSC1; GDSC2 5.7081 7.6088 2.6953 0.5151
23132/87 GDSC1; GDSC2 5.9191 12.5681 0.6427 9.9535
RF-48 GDSC1; GDSC2 5.9662 7.6944 2.7632 0.2597
TGBC11TKB GDSC1; GDSC2 6.0757 7.571 2.8443 0.1143
RERF-GC-1B GDSC1; GDSC2 6.1333 14.9205 -0.3347 14.1579
NUGC-3 GDSC1; GDSC2 6.2697 7.9544 2.7823 0.1573
MKN28 GDSC1; GDSC2 6.328 8.3596 2.6633 0.3403
SK-GT-2 GDSC1; GDSC2 6.4744 8.6888 2.6015 0.4186
SNU-1 GDSC1; GDSC2 8.7921 22.3218 -2.0979 16.1311
Hs 746.T GDSC1; GDSC2 8.9534 19.8575 -0.8577 11.5094
SNG-M GDSC1; GDSC2 5.7796 7.6056 2.7246 0.4078
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CGTH-W-1 GDSC1; GDSC2 -1.2212 1.0382 -1.2457 44.0975
B-CPAP GDSC1; GDSC2 4.836 10.507 0.8996 10.8051
ASH-3 GDSC1; GDSC2 5.128 6.505 2.8702 0.331
8305C GDSC1; GDSC2 5.1798 7.2214 2.617 1.1432
FTC-133 GDSC1; GDSC2 5.1861 6.9073 2.7435 0.672
IHH-4 GDSC1; GDSC2 5.2551 6.7087 2.8458 0.3361
CAL-62 GDSC1; GDSC2 5.5152 7.5718 2.6293 0.8314
TT GDSC1; GDSC2 5.5373 8.1311 2.4166 1.6289
K5 GDSC1; GDSC2 5.8368 7.4605 2.7975 0.2343
WRO GDSC1; GDSC2 5.8395 7.5001 2.7847 0.2572
KMH-2 GDSC1; GDSC2 5.8452 7.462 2.8 0.2275
BHT-101 GDSC1; GDSC2 5.8779 7.201 2.9002 0.0831
HTC-C3 GDSC1; GDSC2 5.9204 7.8332 2.6968 0.4159
ML-1 [Human leukemia] GDSC1; GDSC2 5.9548 7.9175 2.6796 0.4425
TT2609-C02 GDSC1; GDSC2 6.0522 7.6337 2.815 0.1553
8505C GDSC1; GDSC2 6.3049 15.0798 -0.2954 13.6481
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 41 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PCI-38 GDSC1 0.072 9.6651 -4.1283 34.08
BB49-HNC GDSC1 3.4817 5.673 0.2681 0.9942
PCI-15A GDSC1; GDSC2 4.047 6.6389 2.222 4.9395
HSC-3 GDSC1; GDSC2 4.7266 6.0988 2.857 0.6067
KOSC-2 GDSC1; GDSC2 4.9054 7.8891 2.1841 3.5662
BICR 10 GDSC1 4.9575 13.9614 -2.5544 13.8278
HSC-2 GDSC1; GDSC2 4.9818 6.2794 2.8951 0.3343
HSC-4 GDSC2 4.9837 6.5163 2.807 0.6182
BICR 31 GDSC2 5.1971 7.0344 2.6991 0.8468
JHU-022 GDSC1; GDSC2 5.4077 7.766 2.5037 1.3917
OSC-20 GDSC1; GDSC2 5.4078 7.1827 2.732 0.5704
HO-1-N-1 GDSC1; GDSC2 5.4188 7.0997 2.7674 0.4634
SCC-9 GDSC1; GDSC2 5.4467 7.12 2.771 0.4398
UPCI-SCC-090 GDSC1; GDSC2 5.502 7.6 2.6126 0.8983
KON GDSC1; GDSC2 5.5555 7.3901 2.7149 0.539
FaDu GDSC1; GDSC2 5.5917 7.0937 2.8359 0.235
CAL-27 GDSC1; GDSC2 5.6137 6.9754 2.8847 0.1469
PE/CA-PJ15 GDSC1; GDSC2 5.6214 7.3424 2.7585 0.3926
BB30-HNC GDSC1; GDSC2 5.6283 7.7725 2.6006 0.8502
SCC-4 GDSC1; GDSC2 5.6476 7.6003 2.6741 0.6068
PCI-30 GDSC1; GDSC2 5.6929 7.4614 2.7432 0.3995
BHY GDSC1; GDSC2 5.7423 7.5568 2.7278 0.4159
PCI-04B GDSC1; GDSC2 5.8032 8.2117 2.5066 1.0503
Ca9-22 GDSC1; GDSC2 5.8041 7.7619 2.6772 0.5168
BICR 22 GDSC1; GDSC2 5.8344 7.298 2.8526 0.1468
HO-1-u-1 GDSC1; GDSC2 5.8522 7.7859 2.6874 0.468
OSC-19 GDSC1; GDSC2 5.8875 7.5306 2.7916 0.2307
JHU-029 GDSC1; GDSC2 5.9271 8.3178 2.5192 0.9202
SCC-25 GDSC1; GDSC2 5.9675 7.6883 2.7658 0.2545
NCI-H3118 GDSC1; GDSC2 5.9999 8.1322 2.619 0.5772
SAS GDSC1; GDSC2 6.0613 8.0153 2.6853 0.3869
SKN-3 GDSC1; GDSC2 6.1389 7.9786 2.7272 0.2758
CAL-33 GDSC1; GDSC2 6.243 8.0419 2.743 0.2207
JHU-011 GDSC1; GDSC2 6.2682 8.6633 2.5304 0.6849
BICR 78 GDSC1; GDSC2 6.284 8.2757 2.6765 0.3283
PCI-06A GDSC1; GDSC2 6.2987 8.4348 2.6256 0.4307
Detroit 562 GDSC1; GDSC2 6.3009 7.9814 2.784 0.1492
SCC-15 GDSC1; GDSC2 6.3152 8.3187 2.6729 0.3254
LB771-HNC GDSC1; GDSC2 6.4011 8.4806 2.6478 0.3476
DOK GDSC1; GDSC2 6.4136 8.5731 2.6198 0.4012
SAT [Human HNSCC] GDSC1; GDSC2 6.527 8.8793 2.5534 0.507
⏷ Show the Full List of 41 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BFTC-905 GDSC1; GDSC2 4.5347 6.1738 2.7348 1.2984
RT-112 GDSC1; GDSC2 4.6274 6.472 2.6557 1.5584
KU-19-19 GDSC1; GDSC2 4.8654 6.2343 2.8645 0.4867
639V GDSC1; GDSC2 4.9207 5.816 3.0355 0.0772
HT-1197 GDSC1; GDSC2 5.0013 7.9837 2.1972 3.3488
UM-UC-3 GDSC1; GDSC2 5.0746 6.8117 2.732 0.792
CAL-29 GDSC1; GDSC2 5.1812 6.7632 2.7962 0.5083
SW1710 GDSC1; GDSC2 5.3241 7.5161 2.5655 1.2188
TCCSUP GDSC1; GDSC2 5.3262 7.0701 2.7406 0.592
647V GDSC1; GDSC2 5.4341 6.7599 2.8947 0.1738
RT-4 GDSC1; GDSC2 5.5195 7.3829 2.7029 0.5936
5637 GDSC1; GDSC2 5.9411 7.6753 2.7607 0.272
SW780 GDSC1; GDSC2 5.9748 7.6429 2.7843 0.22
T24 GDSC1; GDSC2 6.0963 8.0347 2.6916 0.3604
J82 GDSC1; GDSC2 6.5968 8.4437 2.7308 0.1639
HT-1376 GDSC1; GDSC2 6.8406 9.0355 2.6149 0.2817
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HEC-1 GDSC1; GDSC2 3.9162 6.5046 2.1946 5.3902
PA-1 GDSC1; GDSC2 4.3253 6.7755 2.3426 3.686
HeLa GDSC1; GDSC2 4.4533 5.428 2.9975 0.3229
CAL-39 GDSC1; GDSC2 4.9756 7.2198 2.5175 1.7881
KGN GDSC1; GDSC2 5.0184 8.0855 2.1614 3.5102
NCC-IT GDSC2 5.2213 6.709 2.8325 0.399
SW962 GDSC1; GDSC2 5.3027 8.1595 2.2862 2.4828
SKG-IIIa GDSC1; GDSC2 5.3303 6.9703 2.7797 0.4746
DoTc2 4510 GDSC1; GDSC2 5.4546 7.2399 2.7298 0.5506
NEC8 GDSC1; GDSC2 5.507 28.9376 -7.7136 33.7107
PWR-1E GDSC1; GDSC2 5.5174 7.4135 2.6906 0.632
SiHa GDSC1; GDSC2 5.6103 6.8753 2.9175 0.1038
OVCA420 GDSC1; GDSC2 5.6262 7.2653 2.788 0.3219
JAR GDSC1; GDSC2 5.6309 7.2087 2.8099 0.2738
ACC-OV7 GDSC1; GDSC2 5.6331 9.2688 1.982 3.5362
JHOS-3 GDSC1; GDSC2 5.6955 7.9278 2.5698 0.9083
HT-3 GDSC1; GDSC2 5.7124 7.4061 2.7705 0.3287
C-4-I GDSC1; GDSC2 5.7294 7.2195 2.8422 0.1861
NT2-D1 GDSC1; GDSC2 5.7618 7.4082 2.7882 0.2745
MS751 GDSC1; GDSC2 5.7725 7.216 2.8587 0.1509
OMC-1 [Human cervical carcinoma] GDSC1; GDSC2 5.7893 7.5075 2.7634 0.3163
PEO1 GDSC1; GDSC2 5.8184 7.6528 2.7225 0.3967
HEY GDSC1; GDSC2 5.8524 7.8863 2.6507 0.5645
DSH1 GDSC1; GDSC2 5.8655 7.6458 2.743 0.3328
JEG-3 GDSC1; GDSC2 5.8992 7.5097 2.8031 0.2079
SiSo GDSC1; GDSC2 5.9503 8.2042 2.5721 0.7383
C-33 A GDSC1; GDSC2 5.9677 7.8538 2.7074 0.373
BPH-1 GDSC1; GDSC2 5.9952 9.2588 2.1744 2.1994
OV17R GDSC1; GDSC2 6.0285 16.1494 -1.0001 17.1574
TC-YIK GDSC1; GDSC2 6.0491 7.9459 2.7054 0.3479
OVCA433 GDSC1; GDSC2 6.1001 7.9968 2.7065 0.3282
SW954 GDSC1; GDSC2 6.1092 7.7251 2.8039 0.1592
LB831-BLC GDSC1; GDSC2 6.1118 7.7223 2.8058 0.1561
Ca Ski GDSC1; GDSC2 6.1545 8.5918 2.5107 0.8051
SKN GDSC1; GDSC2 6.2566 8.1969 2.694 0.3029
UWB1.289 GDSC1; GDSC2 6.4899 8.9068 2.529 0.582
OVMIU GDSC1; GDSC2 6.7181 9.1373 2.5339 0.4771
ME-180 GDSC1; GDSC2 7.3844 17.6519 -0.8064 13.8123
SW756 GDSC1; GDSC2 8.7648 29.6248 -5.6159 25.1138
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5660).
2 Clinical pipeline report, company report or official report of Amgen (2009).