Details of the Drug

General Information of Drug (ID: DMZHB37)

Drug Name
GSK2110183
Indication
Disease Entry ICD 11 Status REF
leukaemia 2A60-2B33 Phase 2 [1]
Solid tumour/cancer 2A00-2F9Z Phase 2 [2]
Multiple myeloma 2A83 Phase 1 [3]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 427.3
Logarithm of the Partition Coefficient (xlogp) 4
Rotatable Bond Count (rotbonds) 6
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 5
Chemical Identifiers
Formula
C18H17Cl2FN4OS
IUPAC Name
N-[(2S)-1-amino-3-(3-fluorophenyl)propan-2-yl]-5-chloro-4-(4-chloro-2-methylpyrazol-3-yl)thiophene-2-carboxamide
Canonical SMILES
CN1C(=C(C=N1)Cl)C2=C(SC(=C2)C(=O)N[C@@H](CC3=CC(=CC=C3)F)CN)Cl
InChI
InChI=1S/C18H17Cl2FN4OS/c1-25-16(14(19)9-23-25)13-7-15(27-17(13)20)18(26)24-12(8-22)6-10-3-2-4-11(21)5-10/h2-5,7,9,12H,6,8,22H2,1H3,(H,24,26)/t12-/m0/s1
InChIKey
AFJRDFWMXUECEW-LBPRGKRZSA-N
Cross-matching ID
PubChem CID
46843057
ChEBI ID
CHEBI:131168
CAS Number
1047644-62-1
UNII
8739X25QI3
DrugBank ID
DB11648
TTD ID
D02NXM
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
RAC-alpha serine/threonine-protein kinase (AKT1) TTWTSCV AKT1_HUMAN Modulator [4]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
(3R)-3-hydroxyacyl-CoA dehydrogenase (HSD17B8) OTX1DWEF DHB8_HUMAN Gene/Protein Processing [5]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 (PLCD1) OT6WFVXZ PLCD1_HUMAN Gene/Protein Processing [5]
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) OTRT3F3U HMDH_HUMAN Gene/Protein Processing [5]
3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 (HSD17B7) OTV7VOV3 DHB7_HUMAN Gene/Protein Processing [5]
5-hydroxytryptamine receptor 2B (HTR2B) OTM1AD9J 5HT2B_HUMAN Gene/Protein Processing [5]
5-oxoprolinase (OPLAH) OTX7S4OW OPLA_HUMAN Gene/Protein Processing [5]
A disintegrin and metalloproteinase with thrombospondin motifs 10 (ADAMTS10) OTNJ9VSU ATS10_HUMAN Gene/Protein Processing [5]
A disintegrin and metalloproteinase with thrombospondin motifs 13 (ADAMTS13) OTXKH5P9 ATS13_HUMAN Gene/Protein Processing [5]
Acetyl-CoA acetyltransferase, cytosolic (ACAT2) OTZ092ZJ THIC_HUMAN Gene/Protein Processing [5]
Acetyl-coenzyme A synthetase, cytoplasmic (ACSS2) OTB1FZJU ACSA_HUMAN Gene/Protein Processing [5]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease leukaemia
ICD Disease Classification 2A60-2B33
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
RAC-alpha serine/threonine-protein kinase (AKT1) DTT AKT1 4.61E-02 -0.04 -0.1
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 34 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC2 3.9066 5.9827 0.8904 0.7795
ES7 GDSC2 0.3897 6.6023 -1.9782 25.0453
SK-PN-DW GDSC2 1.2401 4.2413 -0.0405 11.3283
ES5 GDSC2 1.597 6.317 -0.771 14.6752
EW-7 GDSC2 2.3492 6.2665 -0.1535 8.9311
EW-3 GDSC2 2.3933 9.7769 -1.8584 18.2224
EW-24 GDSC2 2.4236 6.2021 -0.0675 8.2298
SaOS-2 GDSC2 2.7242 6.9242 -0.2051 8.3615
ES8 GDSC2 2.7473 8.4686 -0.9428 12.5638
EW-11 GDSC2 2.8975 11.1197 -2.1376 18.2177
CHSA8926 GDSC2 2.8989 7.3625 -0.2956 8.5066
EW-22 GDSC2 2.9279 6.3764 0.1947 5.5666
EW-18 GDSC2 2.9306 6.3862 0.1918 5.5781
HuO9 GDSC2 2.9472 6.4267 0.1834 5.5942
HOS GDSC2 2.9506 7.1726 -0.169 7.6535
SK-ES-1 GDSC2 3.1221 4.9273 0.9546 1.1806
EW-13 GDSC2 3.287 5.3002 0.8811 1.3331
NOS-1 [Human HNSCC] GDSC2 3.4977 14.0605 -3.1393 20.8756
A-673 GDSC2 3.5088 5.3573 0.9602 0.8168
HuO-3N1 GDSC2 3.5898 6.4243 0.5611 2.4815
MG-63 GDSC2 3.6097 8.4217 -0.3294 7.2514
H-EMC-SS GDSC2 3.6216 8.3346 -0.2812 6.9607
CAL-78 GDSC2 3.7955 5.8814 0.8818 1.0627
TC-71 GDSC2 3.8295 5.5334 1.0263 0.4191
CAL-72 GDSC2 3.9009 5.6112 1.0258 0.3888
ES4 GDSC2 4.093 6.1146 0.9176 0.7026
G-292 clone A141B1 GDSC2 4.0992 6.339 0.836 0.8334
CADO-ES1 GDSC2 4.1536 5.6741 1.0969 0.1676
MHH-ES-1 GDSC2 4.1731 5.7641 1.073 0.201
NY GDSC2 4.1983 15.4041 -3.2862 19.8534
EW-16 GDSC2 4.2184 6.4229 0.8538 0.8449
ES6 GDSC2 4.2787 6.7173 0.7677 0.9422
EW-1 GDSC2 4.3471 6.5956 0.8418 0.802
U2OS GDSC2 4.7608 6.945 0.8758 0.4005
⏷ Show the Full List of 34 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OACM5.1 C GDSC2 1.14 4.6136 -0.3145 13.3476
OACP4 C GDSC2 2.0805 5.3191 0.1131 7.9617
FLO-1 GDSC2 2.7601 7.1864 -0.3072 8.8844
SK-GT-4 GDSC2 2.9415 8.3592 -0.749 11.0193
KYSE-220 GDSC2 3.1425 6.1333 0.4403 3.7735
ESO-26 GDSC2 3.4756 13.8203 -3.0374 20.5451
KYSE-50 GDSC2 3.8341 5.5135 1.0353 0.3942
ESO-51 GDSC2 4.0221 6.3565 0.7962 1.2291
KYAE-1 GDSC2 4.1173 5.6875 1.0794 0.2044
TE-12 GDSC2 4.5141 7.8744 0.4162 2.1055
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC2 1.0491 6.602 -1.383 19.8091
Cancer Drug Sensitivity Data Curated from 19 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CHP-212 GDSC2 2.406 10.2263 -2.072 21.8693
SJNB-14 GDSC2 2.5323 4.7787 0.6916 3.4219
KP-N-YN GDSC2 2.6049 11.0979 -2.3505 19.9069
SJNB-13 GDSC2 2.8254 5.3805 0.5943 3.4506
SK-N-DZ GDSC2 2.8538 4.5317 0.9864 1.3322
Kelly GDSC2 3.0558 5.4409 0.7009 2.4994
NB69 GDSC2 3.0972 8.0053 -0.4691 9.0791
TGW GDSC2 3.1147 4.5627 1.0966 0.6191
NB(TU)1 GDSC2 3.157 5.4187 0.7653 2.4352
SJNB-7 GDSC2 3.25 5.3294 0.8508 1.5085
SK-N-BE(2)-M17 GDSC2 3.3124 5.1002 0.9737 0.9229
IMR-5 GDSC2 3.5661 5.5412 0.9136 0.9443
GOTO GDSC2 3.6082 6.0858 0.7133 1.7401
SiMa GDSC2 3.8519 5.7369 0.9603 0.5921
SK-N-AS GDSC2 3.861 5.5483 1.0331 0.3879
SJNB-10 GDSC2 3.9098 6.01 0.8813 0.8076
CHP-134 GDSC2 3.9266 6.0081 0.8891 0.7706
NH-12 GDSC2 4.0329 6.0253 0.9265 0.7103
GI-ME-N GDSC2 4.0549 8.3277 -0.0185 5.704
⏷ Show the Full List of 19 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC2 2.6713 5.4347 0.4726 4.4378
Cancer Drug Sensitivity Data Curated from 42 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Evsa-T GDSC2 -2.6023 1.7792 -3.0392 50.3293
OCUB-M GDSC2 -1.8862 0.1289 -1.927 35.0329
HCC2157 GDSC2 -0.9141 1.2279 -1.0538 25.7996
MDA-MB-453 GDSC2 -0.5716 2.1864 -0.9565 23.695
BT-20 GDSC2 -0.3904 3.7561 -1.3941 25.2485
HCC1569 GDSC2 -0.0176 5.7741 -1.9593 26.4937
HCC1954 GDSC2 0.3778 5.5579 -1.4794 22.653
CAL-51 GDSC2 0.546 4.4015 -0.7612 21.4816
MDA-MB-415 GDSC2 0.607 12.4785 -4.6968 33.3015
CAMA-1 GDSC2 1.0708 4.9751 -0.5555 15.0382
MFM-223 GDSC2 1.207 5.6053 -0.7483 15.7436
Hs 578T GDSC2 1.5404 5.7282 -0.5239 13.3776
MDA-MB-361 GDSC2 1.5897 5.8487 -0.5429 13.3456
MDA-MB-330 GDSC2 1.7532 7.0187 -0.993 15.4914
HCC70 GDSC2 1.798 8.1517 -1.5225 18.2177
T-47D GDSC2 1.8287 6.3042 -0.5747 12.8461
EFM-192A GDSC2 2.3844 5.8387 0.0819 7.412
CAL-85-1 GDSC2 2.4069 8.54 -1.2336 15.0128
EFM-19 GDSC2 2.444 8.0513 -0.9632 13.4362
DU4475 GDSC2 2.5568 4.2343 0.9557 1.8915
BT-474 GDSC2 2.59 7.2504 -0.4601 10.1822
AU565 GDSC2 3.1273 10.7928 -1.8054 18.4251
HCC1187 GDSC2 3.2184 7.2117 -0.0115 6.198
CAL-120 GDSC2 3.277 5.2884 0.881 1.3438
ZR-75-30 GDSC2 3.5486 5.1477 1.0564 0.476
COLO 824 GDSC2 3.5501 6.4181 0.5429 2.6237
HCC1143 GDSC2 3.573 9.3585 -0.7959 9.8994
HCC1806 GDSC2 3.5906 5.3211 1.0088 0.5962
HCC1419 GDSC2 3.6081 13.6154 -2.8387 19.4727
HCC1500 GDSC2 3.6906 5.4996 0.983 0.6166
BT-549 GDSC2 3.6999 6.2287 0.6991 2.0457
HDQ-P1 GDSC2 3.7414 5.6844 0.9343 0.7425
HCC1937 GDSC2 3.7537 10.8235 -1.3757 12.5639
MDA-MB-231 GDSC2 3.8088 5.9913 0.8449 1.0095
HCC38 GDSC2 3.8797 6.6251 0.6231 1.8535
MDA-MB-157 GDSC2 3.8989 6.3378 0.7486 1.3055
HCC1428 GDSC2 3.9127 5.1189 1.2005 0.0788
JIMT-1 GDSC2 3.9797 5.5499 1.0772 0.2965
MDA-MB-436 GDSC2 4.0772 6.2202 0.8718 0.732
MRK-nu-1 GDSC2 4.0926 5.3509 1.1844 0.0716
MCF-7 GDSC2 4.1424 5.941 0.9998 0.3534
MDA-MB-468 GDSC2 4.6209 13.2478 -1.9517 13.5402
⏷ Show the Full List of 42 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 34 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SF539 GDSC2 1.2554 5.7016 -0.754 15.6232
LN-405 GDSC2 2.1177 5.4196 0.0915 9.5683
GI-1 GDSC2 2.2637 6.2722 -0.2199 9.546
8-MG-BA GDSC2 2.2905 5.5884 0.1365 7.3001
42-MG-BA GDSC2 2.3153 7.8472 -0.9603 13.7541
CAS-1 GDSC2 2.3568 5.2801 0.3344 5.9316
SK-MG-1 GDSC2 2.4204 4.6918 0.6605 3.8233
LN-229 GDSC2 2.5094 6.805 -0.3004 9.4286
SW1088 GDSC2 2.6278 7.077 -0.3479 9.4304
H4 GDSC2 2.6472 11.0617 -2.2998 19.5764
LN-18 GDSC2 2.7078 4.2836 1.0166 1.6387
KS-1 [Human Krukenberg tumour] GDSC2 2.7955 9.469 -1.3993 14.8941
Becker GDSC2 2.9293 5.5054 0.5994 3.2455
U-251MG GDSC2 2.9387 5.5821 0.5702 3.3922
T98G GDSC2 2.9797 6.6025 0.1215 5.8918
DK-MG GDSC2 3.0171 4.8288 0.9439 1.6102
ONS-76 GDSC2 3.0637 5.4296 0.7102 2.4392
D-263MG GDSC2 3.3126 5.3573 0.8699 1.3555
U-118MG GDSC2 3.3192 6.083 0.5639 2.8347
GaMG GDSC2 3.3804 10.9786 -1.7126 15.0633
AM-38 GDSC2 3.3808 5.3793 0.8934 1.424
D283 Med GDSC2 3.3843 4.8448 1.1024 0.4309
U-87MG ATCC GDSC2 3.3957 4.7253 1.1505 0.2973
KINGS-1 GDSC2 3.4089 6.5829 0.3925 3.6074
YH-13 GDSC2 3.4956 11.3346 -1.8038 15.2371
Daoy GDSC2 3.5319 5.3915 0.957 0.9732
M059J GDSC2 3.9368 6.128 0.8476 0.9045
KALS-1 GDSC2 4.1399 10.0112 -0.7369 8.475
SF268 GDSC2 4.1434 6.1667 0.9185 0.557
GB-1 GDSC2 4.2648 5.7401 1.1134 0.148
D-392MG GDSC2 4.2933 6.7244 0.7712 0.9209
DBTRG-05MG GDSC2 4.352 6.1101 1.0179 0.2987
PFSK-1 GDSC2 4.3686 7.1111 0.6544 1.2786
A-172 GDSC2 4.4701 5.9683 1.1074 0.0987
⏷ Show the Full List of 34 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ETK-1 GDSC2 4.3081 6.554 0.8414 0.6908
TGBC24TKB GDSC2 4.3604 6.3882 0.9227 0.4467
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RL95-2 GDSC2 0.3036 4.5791 -1.0791 20.7799
EN GDSC2 1.3404 8.2105 -1.9338 21.6295
MFE-280 GDSC2 2.0369 5.3364 0.0713 8.3328
AN3-CA GDSC2 2.3669 10.1422 -2.0607 21.9386
ESS-1 GDSC2 3.2531 6.8943 0.1581 5.1654
KLE GDSC2 3.4244 5.3379 0.9302 0.9981
MFE-319 GDSC2 3.9439 5.7548 0.9905 0.4596
MFE-296 GDSC2 4.2184 6.0445 0.9916 0.3436
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 128 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H929 GDSC2 -2.6787 0.1767 -2.7729 43.1063
DoHH2 GDSC2 -2.6742 -0.701 -2.6897 42.8035
SU-DHL-6 GDSC2 -2.1611 -0.9286 -2.1625 37.5992
SU-DHL-5 GDSC2 -1.4907 -0.1187 -1.4997 30.9103
MM1.S GDSC2 -1.0594 1.1995 -1.2055 27.2875
WSU-NHL GDSC2 -0.6646 0.789 -0.7074 22.7928
SU-DHL-10 GDSC2 -0.5058 2.1194 -0.8622 22.8858
Jurkat GDSC2 -0.2059 2.4746 -0.6683 24.5416
NALM-6 GDSC2 0.1033 4.7319 -1.3462 22.995
A4/Fukuda GDSC2 0.363 2.9367 -0.2617 15.803
Hs 445 GDSC2 0.5867 4.8569 -0.9427 18.9712
Loucy GDSC2 0.8064 5.3713 -0.9906 18.4727
Farage GDSC2 0.8107 4.1288 -0.3785 14.8478
Karpas-620 GDSC2 0.8828 4.4454 -0.4657 15.1267
HAL-01 GDSC2 0.9536 4.0588 -0.2108 13.3299
P32/ISH GDSC2 1.0029 3.7388 -0.0086 11.9134
KE-37 GDSC2 1.0869 5.6348 -0.8686 16.833
Karpas-422 GDSC2 1.1 6.8865 -1.4801 20.1509
MOLT-16 GDSC2 1.1456 6.6605 -1.3277 22.4225
OPM-2 GDSC2 1.388 4.8872 -0.2331 12.0619
PF-382 GDSC2 1.4106 5.4595 -0.4994 13.6222
MOLP-8 GDSC2 1.4177 4.0505 0.2102 9.1993
JVM-2 GDSC2 1.4301 5.5585 -0.5323 13.7608
L-363 GDSC2 1.4923 4.4317 0.0837 9.7699
U-698-M GDSC2 1.5559 4.0811 0.3126 8.1387
Karpas-45 GDSC2 1.6104 4.7109 0.0431 9.6766
SUP-T1 GDSC2 1.6588 4.8829 -0.0029 9.8249
Jiyoye GDSC2 1.7375 5.2574 -0.1257 10.3664
HDLM-2 GDSC2 1.7438 3.7186 0.6475 5.4898
GA-10 GDSC2 1.7465 4.4137 0.3029 9.1779
CESS GDSC2 1.8444 6.2479 -0.534 14.8828
L-1236 GDSC2 1.8674 5.7254 -0.2549 10.8018
OCI-AML-3 GDSC2 1.8913 5.3398 -0.0436 9.4318
P30/OHK GDSC2 1.9116 6.1861 -0.4494 11.8636
CCRF-CEM GDSC2 1.9143 4.5042 0.3899 6.6597
ALL-PO GDSC2 1.9486 5.1578 0.0918 10.0909
Namalwa GDSC2 1.9775 4.5657 0.4077 6.3859
P12-Ichikawa GDSC2 1.9929 6.1488 -0.3665 13.2373
Daudi GDSC2 1.9999 3.6631 0.8681 4.1577
AMO1 GDSC2 2.0023 4.2765 0.5692 5.3145
RC-K8 GDSC2 2.0232 5.2011 0.1279 9.5914
ML-2 GDSC2 2.0239 4.0749 0.6842 4.5467
WIL2 NS GDSC2 2.0372 4.9978 0.2392 7.2872
Ramos.2G6.4C10 GDSC2 2.1189 3.8885 0.8421 3.3589
CA46 GDSC2 2.1482 4.0346 0.7918 4.3212
ST486 GDSC2 2.1518 4.9608 0.343 6.3574
KY821 GDSC2 2.1735 4.9287 0.3746 6.1098
Ku812 GDSC2 2.1808 5.1231 0.2846 6.6496
EB2 GDSC2 2.1855 6.6374 -0.4599 11.1922
Reh GDSC2 2.2166 7.5664 -0.8971 13.6593
ATN-1 GDSC2 2.2208 4.1346 0.7932 3.4379
JSC-1 GDSC2 2.2405 6.5741 -0.3866 10.6117
BC-1 GDSC2 2.2464 7.4567 -0.8195 13.1381
KMS-12-BM GDSC2 2.3113 3.8792 0.9718 2.2092
RPMI-6666 GDSC2 2.3449 6.2857 -0.1661 9.0182
ME1 GDSC2 2.3563 4.3307 0.7894 3.1862
HH [Human lymphoma] GDSC2 2.3745 6.3422 -0.1721 8.982
U266B1 GDSC2 2.3759 4.7639 0.5965 4.2976
ALL-SIL GDSC2 2.446 4.9959 0.5327 5.4378
MOLM-13 GDSC2 2.4642 4.9472 0.5681 4.2853
697 GDSC2 2.4858 4.6534 0.7208 3.3398
RPMI-8226 GDSC2 2.4876 7.5873 -0.7012 11.8383
Karpas-299 GDSC2 2.5006 4.4738 0.8136 2.7758
Raji GDSC2 2.5164 4.844 0.6509 4.427
ARH-77 GDSC2 2.5244 6.1961 0.0077 7.5391
VL51 GDSC2 2.5248 4.6574 0.7435 3.1352
DEL GDSC2 2.5804 4.1061 1.0255 1.4901
EJM GDSC2 2.6056 5.7776 0.2661 6.9417
LAMA-84 GDSC2 2.6667 4.9784 0.6826 3.2283
OCI-AML-5 GDSC2 2.6928 7.9365 -0.7216 11.451
TUR GDSC2 2.7321 4.4259 0.9682 1.5751
MN-60 GDSC2 2.7726 5.5581 0.4794 4.2048
RS4;11 GDSC2 2.7922 7.2867 -0.3332 8.965
JURL-MK1 GDSC2 2.7959 13.8598 -3.5748 24.1013
MOLT-13 GDSC2 2.8053 5.4659 0.5426 3.78
H9 GDSC2 2.8312 5.9801 0.319 5.0282
SUP-HD1 GDSC2 2.8553 6.1957 0.2328 5.4859
A3/Kawakami GDSC2 2.8814 3.9804 1.2199 0.3623
VAL GDSC2 2.9051 4.9294 0.8426 1.9782
JVM-3 GDSC2 2.9224 5.328 0.6755 2.8381
Karpas-1106P GDSC2 2.9575 4.8009 0.9254 1.4983
OCI-M1 GDSC2 2.9719 4.2934 1.1388 0.5733
IM-9 GDSC2 3.0024 4.8419 0.931 1.4187
RPMI-8866 GDSC2 3.0042 6.0904 0.3765 4.372
L-540 GDSC2 3.0064 5.3056 0.7331 2.4021
DG-75 GDSC2 3.1052 5.7399 0.5959 2.9834
K-562 GDSC2 3.1161 5.0642 0.8949 1.4562
SUP-M2 GDSC2 3.188 4.2936 1.2259 0.2046
SKM-1 GDSC2 3.2383 4.3706 1.2175 0.2049
BALL-1 GDSC2 3.2494 5.23 0.8917 1.3252
NOMO-1 GDSC2 3.2743 4.9769 1.0053 0.8327
MLMA GDSC2 3.3255 6.7748 0.2571 4.4832
GR-ST GDSC2 3.3737 6.1647 0.5579 2.7879
HEL GDSC2 3.3739 4.6229 1.1788 0.2401
Kasumi-1 GDSC2 3.3773 10.4998 -1.4814 13.9284
KM-H2 GDSC2 3.3782 5.7266 0.7487 2.2028
LP-1 GDSC2 3.4507 5.555 0.8552 1.2805
L-428 GDSC2 3.469 5.2848 0.9709 0.8077
HL-60 GDSC2 3.4693 4.6172 1.2158 0.1404
BL-41 GDSC2 3.4985 4.9138 1.1222 0.3231
SCC-3 GDSC2 3.5107 4.7098 1.1987 0.1584
SU-DHL-8 GDSC2 3.5304 4.9212 1.1317 0.2873
OCI-AML-2 GDSC2 3.5399 4.7127 1.2082 0.1358
Karpas-231 GDSC2 3.5655 4.8822 1.1587 0.2167
HC-1 GDSC2 3.5883 5.4145 0.9723 0.7172
CTV-1 GDSC2 3.6263 5.2241 1.0593 0.4278
MHH-CALL-2 GDSC2 3.6333 5.2902 1.0377 0.4845
BE-13 GDSC2 3.6741 5.339 1.0361 0.468
MOLT-4 GDSC2 3.6831 5.6089 0.9383 0.7683
KOPN-8 GDSC2 3.6872 5.25 1.0737 0.4345
EM-2 GDSC2 3.6965 5.1225 1.1227 0.2469
TK [Human B-cell lymphoma] GDSC2 3.7194 5.0881 1.1432 0.1999
DND-41 GDSC2 3.7504 5.4376 1.0302 0.4461
CML-T1 GDSC2 3.7646 5.3015 1.0848 0.3045
MHH-PREB-1 GDSC2 3.7901 5.6978 0.9496 0.6615
SK-MM-2 GDSC2 3.8084 5.4689 1.0414 0.4679
GDM-1 GDSC2 3.8278 6.3665 0.704 1.5548
EoL-1 GDSC2 3.8398 5.4115 1.074 0.3005
SR GDSC2 3.8532 5.3139 1.1133 0.2164
SUP-B15 GDSC2 3.9599 5.7418 1.0014 0.424
JJN-3 GDSC2 4.0275 5.6932 1.0445 0.357
KG-1 GDSC2 4.0315 6.1211 0.8901 0.7022
KMOE-2 GDSC2 4.0867 5.9103 0.9895 0.3991
Granta-519 GDSC2 4.1545 5.7934 1.0561 0.2821
DB GDSC2 4.1872 6.3921 0.8525 0.7263
KCL-22 GDSC2 4.2725 5.9382 1.0486 0.2165
MEG-01 GDSC2 4.4157 6.3033 0.9737 0.3137
LC4-1 GDSC2 4.5267 6.5257 0.9366 0.3529
⏷ Show the Full List of 128 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 19 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CAL-54 GDSC2 1.7366 13.4446 -4.219 28.8457
BFTC-909 GDSC2 1.8568 9.2563 -2.0266 20.5091
KTCTL-195 GDSC2 2.4881 7.4625 -0.6393 11.479
SW13 GDSC2 2.601 4.3887 0.9119 2.0593
A-498 GDSC2 2.6898 14.838 -4.1448 28.676
LB996-RCC GDSC2 2.7326 6.9868 -0.2296 8.4877
RCC10RGB GDSC2 2.8057 4.588 0.9373 1.6323
OS-RC-2 GDSC2 2.8433 8.9787 -1.1228 13.3156
RXF 393L GDSC2 3.0207 11.4802 -2.223 18.2945
786-O GDSC2 3.2374 9.3896 -1.0407 11.951
A-704 GDSC2 3.377 6.7195 0.3127 4.0908
TK-10 GDSC2 3.4767 7.1152 0.192 4.5889
KMRC-20 GDSC2 3.6466 6.1162 0.7195 2.0045
ACHN GDSC2 3.8122 6.1589 0.7803 1.2551
HA7-RCC GDSC2 4.0105 5.8826 0.97 0.4823
769-P GDSC2 4.1392 6.1294 0.9305 0.5263
SN12C GDSC2 4.1861 5.6101 1.1299 0.1165
NCC010 GDSC2 4.3769 6.6865 0.8201 0.7158
VMRC-RCZ GDSC2 4.4521 6.0882 1.0609 0.1573
⏷ Show the Full List of 19 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 46 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LoVo GDSC2 -0.1973 5.162 -1.8426 26.6668
SNU-C1 GDSC2 0.7493 5.1477 -0.9331 18.3426
KM12 GDSC2 0.8933 5.3742 -0.913 17.7332
DiFi GDSC2 1.1906 5.1539 -0.5379 14.5433
GP5d GDSC2 1.567 5.7066 -0.4908 13.0991
LS513 GDSC2 1.632 4.3921 0.2204 8.4995
SW948 GDSC2 1.844 5.4525 -0.1374 10.1425
SW48 GDSC2 1.9566 4.7371 0.3069 7.07
HCC2998 GDSC2 2.0078 8.2195 -1.3869 16.9117
SNU-81 GDSC2 2.1233 6.0816 -0.232 9.9778
HT-29 GDSC2 2.1971 7.2895 -0.7746 13.0111
SNU-175 GDSC2 2.1998 6.0775 -0.1718 9.4142
RKO GDSC2 2.3002 5.4352 0.2185 6.7731
SNU-C5 GDSC2 2.4163 6.0868 -0.0163 7.9359
LS411N GDSC2 2.4254 9.6164 -1.7536 17.63
CCK-81 GDSC2 2.4735 10.8947 -2.3518 20.2578
C2BBe1 GDSC2 2.4823 5.6329 0.2512 6.1575
T84 GDSC2 2.5118 5.6988 0.2399 6.1612
HCT 15 GDSC2 2.5287 7.5144 -0.6347 11.3514
COLO205 GDSC2 2.5545 5.4582 0.3846 5.1972
NCI-H716 GDSC2 2.6364 7.0879 -0.3471 9.4054
SW1463 GDSC2 2.7238 4.7688 0.8121 2.8895
NCI-H747 GDSC2 2.7923 5.1155 0.6955 2.9392
SNU-61 GDSC2 2.9361 4.9727 0.8405 2.3353
SK-CO-1 GDSC2 3.0387 4.9876 0.888 1.5794
SNU-1040 GDSC2 3.0558 13.0528 -2.9741 21.3061
SNU-407 GDSC2 3.1608 6.3935 0.3325 4.3445
CW-2 GDSC2 3.2658 6.0933 0.5296 3.0937
HCT 116 GDSC2 3.2685 4.9293 1.0213 0.7767
RCM-1 [Human ESC] GDSC2 3.4227 5.1436 1.0055 0.7185
CL-11 GDSC2 3.4803 6.3338 0.5421 2.7214
SW1116 GDSC2 3.5611 5.3905 0.9699 0.7442
HT-55 GDSC2 3.5836 4.8894 1.1628 0.203
HT115 GDSC2 3.6191 4.7577 1.2207 0.1016
LS1034 GDSC2 3.6401 4.9997 1.145 0.2203
COLO 320HSR GDSC2 3.7433 5.8131 0.8856 0.9107
SW1417 GDSC2 3.7433 5.5358 0.991 0.5613
LS180 GDSC2 3.8608 5.3709 1.0962 0.247
MDST8 GDSC2 3.8953 5.1256 1.1923 0.09
LS123 GDSC2 3.9854 5.7918 0.9932 0.4335
CaR-1 GDSC2 4.0162 6.0646 0.905 0.6651
COLO 678 GDSC2 4.0278 5.7308 1.0313 0.3258
SW620 GDSC2 4.1948 5.6207 1.1294 0.1157
SW626 GDSC2 4.4003 6.8039 0.7858 0.8066
SW837 GDSC2 4.5918 6.3456 1.0225 0.1831
SNU-C2B GDSC2 4.824 7.6555 0.6406 1.0066
⏷ Show the Full List of 46 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC2 3.7221 5.2053 1.103 0.2798
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHH-2 GDSC2 1.4536 11.988 -3.7264 28.1922
JHH-6 GDSC2 1.8229 3.3568 0.8886 3.7635
Hep 3B2.1-7 GDSC2 1.9248 4.0203 0.6376 5.0793
SNU-423 GDSC2 2.3749 7.0581 -0.5244 11.0903
JHH-4 GDSC2 2.9646 5.0066 0.841 1.9049
Hep-G2/C3A GDSC2 3.165 4.8591 1.0024 0.9376
Huh-7 GDSC2 3.2171 5.097 0.9307 1.1882
JHH-1 GDSC2 3.4174 5.1536 0.9993 0.8929
HuH-1 GDSC2 3.4254 7.2459 0.1015 6.1761
SNU-398 GDSC2 3.6064 5.4947 0.9493 0.7841
JHH-7 GDSC2 3.6568 5.4424 0.9905 0.6134
SK-HEP-1 GDSC2 3.8024 5.102 1.1681 0.1381
HLE GDSC2 4.1291 6.0563 0.9532 0.4711
SNU-449 GDSC2 4.2992 6.3327 0.9192 0.4817
SNU-387 GDSC2 4.4631 6.5878 0.8903 0.4825
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 129 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DMS 273 GDSC2 -0.5597 6.0235 -2.6027 31.3545
NCI-H720 GDSC2 -0.3066 2.8074 -0.9061 22.2581
EPLC-272H GDSC2 0.0948 6.751 -2.3251 31.6929
RERF-LC-Sq1 GDSC2 0.2777 4.8874 -1.2513 21.8211
IST-SL2 GDSC2 0.3976 2.777 -0.1565 15.0439
KNS-62 GDSC2 0.6472 5.7252 -1.3106 20.7931
NCI-H2122 GDSC2 1.6126 2.8761 0.9623 4.6351
NCI-H446 GDSC2 1.715 6.3004 -0.6653 13.7084
NCI-H524 GDSC2 1.7824 4.5391 0.269 7.7716
COR-L311 GDSC2 1.8305 3.8091 0.6703 5.1154
NCI-H1155 GDSC2 1.8737 9.2301 -1.9997 20.3349
HCC44 GDSC2 1.8814 4.3765 0.4279 6.5067
Lu-65 GDSC2 1.9305 4.9824 0.1649 8.0268
NCI-H82 GDSC2 1.995 3.9493 0.7247 4.3644
Lu-99A GDSC2 2.1247 5.3246 0.1437 7.6602
DMS 79 GDSC2 2.1706 5.2157 0.2315 7.003
NCI-H1048 GDSC2 2.2053 6.1912 -0.2238 9.7174
LXF 289 GDSC2 2.2122 5.4776 0.1335 8.9796
NCI-H1993 GDSC2 2.2997 5.5239 0.1748 7.0427
NCI-H2795 GDSC2 2.3206 7.1956 -0.6334 11.8682
NCI-H2373 GDSC2 2.4083 9.7071 -1.812 20.5921
CPC-N GDSC2 2.4186 5.8189 0.1161 7.124
EBC-1 GDSC2 2.4195 5.1819 0.4255 6.2777
NCI-H3122 GDSC2 2.4331 8.8163 -1.3505 15.5648
NCI-H526 GDSC2 2.4655 4.8928 0.5947 4.1236
Lu-165 GDSC2 2.4705 5.983 0.0731 7.2663
NCI-H1944 GDSC2 2.5579 6.1527 0.0524 7.193
NCI-H2170 GDSC2 2.587 6.4087 -0.0514 7.753
NCI-H2029 GDSC2 2.6038 5.8988 0.2067 6.1613
PC-14 GDSC2 2.6502 5.6696 0.3476 5.2202
NCI-H358 GDSC2 2.6591 5.5314 0.4191 4.7781
COLO 668 GDSC2 2.6782 7.6793 -0.6061 10.8223
NCI-H322M GDSC2 2.7326 9.0814 -1.2551 14.2952
Calu-3 GDSC2 2.7517 9.4789 -1.4369 15.1972
COR-L105 GDSC2 2.7808 6.5683 0.0057 6.9837
SBC-5 GDSC2 2.803 3.6913 1.2949 0.1946
NCI-H2731 GDSC2 2.8137 8.0319 -0.6807 10.9297
IA-LM GDSC2 2.821 4.8027 0.852 2.0482
NCI-H1755 GDSC2 2.8285 8.6237 -0.9595 12.4602
NCI-H1666 GDSC2 2.8647 6.6535 0.0215 6.7128
NCI-H1781 GDSC2 2.8767 12.4985 -2.8362 23.7587
NCI-H345 GDSC2 2.8839 3.7366 1.3092 0.1347
SW1271 GDSC2 2.9324 6.2505 0.2568 5.1957
HARA [Human squamous cell lung carcinoma] GDSC2 2.9404 7.7292 -0.4441 9.2791
NCI-H1563 GDSC2 2.9437 7.7163 -0.4355 9.2223
NCI-H2023 GDSC2 2.9506 6.4078 0.1945 5.5229
NCI-H3255 GDSC2 2.9878 7.7688 -0.4303 9.0948
Lu-135 GDSC2 2.9945 5.4113 0.6796 2.7038
NCI-H2227 GDSC2 3.0164 5.3152 0.7344 2.3807
NCI-H1975 GDSC2 3.0232 6.8596 0.0283 6.3491
HOP-62 GDSC2 3.103 6.5308 0.2336 5.9882
COR-L23 GDSC2 3.173 4.8667 1.003 1.1133
NCI-H226 GDSC2 3.1972 4.7904 1.0441 0.7479
NCI-H2135 GDSC2 3.2124 5.1897 0.8903 1.3707
HOP-92 GDSC2 3.2703 9.2175 -0.9344 11.302
NCI-H2803 GDSC2 3.3051 5.3924 0.8518 1.4439
NCI-H250 GDSC2 3.363 6.948 0.2004 4.7344
NCI-H2228 GDSC2 3.3733 8.3534 -0.45 8.3913
NCI-H1650 GDSC2 3.3954 5.8811 0.692 2.0868
RERF-LC-KJ GDSC2 3.4039 5.7707 0.7431 1.8328
NCI-H196 GDSC2 3.4044 5.6261 0.8037 1.5532
NCI-H2085 GDSC2 3.4439 10.8193 -1.5896 14.3161
NCI-H2722 GDSC2 3.487 5.8387 0.7562 1.678
HCC366 GDSC2 3.4938 5.7762 0.7854 1.54
NCI-H1694 GDSC2 3.5249 5.2269 1.017 0.6107
LOU-NH91 GDSC2 3.568 5.2735 1.0173 0.5829
NCI-H1915 GDSC2 3.5741 5.3775 0.9805 0.6993
NCI-H596 GDSC2 3.5968 9.0431 -0.6302 8.9437
NCI-H1568 GDSC2 3.5979 5.8723 0.796 1.3886
LCLC-103H GDSC2 3.637 4.8813 1.1849 0.1497
Ms-1 GDSC2 3.6393 5.2274 1.0632 0.411
HCC15 GDSC2 3.644 5.9705 0.7779 1.7039
ABC-1 GDSC2 3.6813 6.4592 0.5936 2.2114
NCI-H2087 GDSC2 3.7016 6.1486 0.7328 1.5566
NCI-H1092 GDSC2 3.7095 5.4317 1.016 0.5064
LC-1/sq GDSC2 3.7096 5.9623 0.8117 1.2198
DMS 53 GDSC2 3.7125 5.7914 0.8805 1.143
Calu-6 GDSC2 3.73 5.5849 0.9672 0.771
NCI-H1581 GDSC2 3.7403 5.9065 0.8477 1.0533
NCI-H1793 GDSC2 3.7578 5.3194 1.0758 0.3277
NCI-H2818 GDSC2 3.7707 5.8461 0.8847 0.8935
NCI-H2369 GDSC2 3.7809 5.0066 1.1929 0.1298
NCI-H810 GDSC2 3.7923 5.3526 1.077 0.3115
NCI-H1876 GDSC2 3.8048 6.4989 0.6387 1.8635
Lu-139 GDSC2 3.827 5.3835 1.0792 0.2939
NCI-H1792 GDSC2 3.8358 5.9112 0.8876 0.8367
NCI-H2405 GDSC2 3.841 6.844 0.5124 2.4062
HCC78 GDSC2 3.8438 11.9639 -1.8639 16.8108
NCI-H522 GDSC2 3.8915 5.7122 0.9853 0.4989
NCI-H1435 GDSC2 3.8939 5.6163 1.0212 0.4032
SHP-77 GDSC2 3.8954 5.1865 1.172 0.1145
DMS 114 GDSC2 3.9116 6.1699 0.8205 1.0201
A-549 GDSC2 3.9137 12.2177 -1.9379 14.9369
NCI-H2141 GDSC2 3.9465 5.8004 0.9748 0.5004
NCI-H650 GDSC2 3.958 5.9955 0.907 0.6936
EMC-BAC-2 GDSC2 3.9681 6.5514 0.695 1.4596
NCI-H841 GDSC2 3.9728 5.4882 1.0962 0.2137
NCI-H23 GDSC2 3.987 5.8356 0.9779 0.4725
NCI-H1963 GDSC2 3.9904 6.0417 0.903 0.6867
NCI-H1693 GDSC2 3.9953 6.4832 0.7347 1.2773
NCI-H1299 GDSC2 4.0095 6.1447 0.8721 0.7732
NCI-H2595 GDSC2 4.0153 6.0064 0.9263 0.6019
HCC827 GDSC2 4.0169 5.7106 1.0344 0.323
NCI-H513 GDSC2 4.0376 5.8578 0.9896 0.5035
NCI-H209 GDSC2 4.0471 6.4091 0.7868 1.0401
NCI-H520 GDSC2 4.0704 11.3771 -1.4268 12.1579
LK-2 GDSC2 4.0982 5.5733 1.1117 0.1576
VMRC-LCD GDSC2 4.1028 5.8353 1.0224 0.3182
NCI-H441 GDSC2 4.1302 6.8899 0.6342 1.56
LCLC-97TM1 GDSC2 4.134 6.3026 0.8642 0.7216
NCI-H727 GDSC2 4.1816 8.03 0.1826 3.5829
NCI-H2869 GDSC2 4.197 6.257 0.9066 0.563
SW1573 GDSC2 4.2019 6.71 0.7375 1.1021
NCI-H211 GDSC2 4.2133 6.3825 0.8668 0.6683
SBC-3 GDSC2 4.2531 6.4641 0.8526 0.6882
SK-LU-1 GDSC2 4.2812 6.0547 1.0113 0.282
SK-MES-1 GDSC2 4.2828 6.1237 0.9877 0.3294
NCI-H1651 GDSC2 4.3548 6.236 0.9748 0.3316
UMC-11 GDSC2 4.3651 5.9271 1.0851 0.1415
NCI-H2804 GDSC2 4.3685 7.4122 0.5349 1.7474
NCI-H2461 GDSC2 4.4018 6.2583 0.9844 0.2971
NCI-H1623 GDSC2 4.4856 6.5625 0.9081 0.517
NCI-H2810 GDSC2 4.5062 7.1861 0.6852 1.0676
NCI-H661 GDSC2 4.5453 6.4292 0.9772 0.3218
NCI-H2591 GDSC2 4.6109 6.8873 0.8393 0.6547
NCI-H1355 GDSC2 4.8411 6.8144 0.9506 0.2369
EKVX GDSC2 4.9958 7.1442 0.8924 0.2953
A-427 GDSC2 5.1872 7.4441 0.8577 0.3045
NCI-H1869 GDSC2 5.7675 15.5677 -2.304 12.9498
⏷ Show the Full List of 129 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC2 2.6157 5.0559 0.6149 3.7117
Cancer Drug Sensitivity Data Curated from 20 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYSE-140 GDSC2 1.424 5.3441 -0.4304 13.1624
TE-6 GDSC2 1.6259 3.887 0.4679 6.954
EC-GI-10 GDSC2 1.9645 5.3165 0.0253 10.5287
OE21 GDSC2 2.1368 5.7008 -0.0331 8.723
OE19 GDSC2 2.2312 5.4515 0.1602 8.7291
KYSE-520 GDSC2 2.3255 5.4511 0.2289 6.6497
TE-8 GDSC2 2.5802 5.9881 0.1475 6.5693
TE-15 GDSC2 2.8261 6.8393 -0.0936 7.4756
KYSE-70 GDSC2 2.994 7.1176 -0.1136 7.2376
KYSE-450 GDSC2 3.2403 6.6573 0.2596 4.6159
KYSE-270 GDSC2 3.2436 6.0664 0.529 3.1304
TE-4 GDSC2 3.29 5.9999 0.5843 3.321
OE33 GDSC2 3.3244 7.7338 -0.1889 7.0074
KYSE-180 GDSC2 3.4405 10.388 -1.3824 13.2842
TE-9 GDSC2 3.4954 5.0784 1.0606 0.4928
TE-5 GDSC2 3.6189 9.2081 -0.694 9.2494
TE-1 GDSC2 3.7927 5.7534 0.9296 0.7241
COLO 680N GDSC2 4.1991 5.849 1.053 0.2284
KYSE-410 GDSC2 4.5702 6.4958 0.9631 0.3443
KYSE-510 GDSC2 6.251 16.6816 -2.5198 13.0074
⏷ Show the Full List of 20 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
EFO-27 GDSC2 -0.3169 8.6959 -3.6578 33.7755
TOV-21G GDSC2 -0.2342 5.3486 -1.9666 27.3888
A2780 GDSC2 0.0316 4.0995 -1.1215 22.064
IGROV-1 GDSC2 0.0779 6.6122 -2.2735 31.5657
OV56 GDSC2 2.0615 4.6138 0.447 5.9307
OVISE GDSC2 2.4142 5.0496 0.4855 4.8864
OVK18 GDSC2 2.6134 5.2092 0.5415 4.1457
TYK-nu GDSC2 2.721 10.8055 -2.1161 18.5668
OV-90 GDSC2 3.1073 6.4556 0.2712 4.7864
OAW42 GDSC2 3.1596 12.4971 -2.6208 19.6538
SK-OV-3 GDSC2 3.3763 7.501 -0.0468 6.1013
OVCAR-3 GDSC2 3.6012 5.3504 1.0021 0.6108
Kuramochi GDSC2 3.7998 6.3203 0.7095 1.559
OVTOKO GDSC2 3.9188 11.0809 -1.387 14.1455
ES-2 GDSC2 3.9483 5.541 1.0688 0.3287
DOV13 GDSC2 4.0204 5.6236 1.0664 0.2555
TOV-112D GDSC2 4.0755 5.8462 1.0083 0.3596
EFO-21 GDSC2 4.1931 5.9006 1.0329 0.2673
OVCAR-8 GDSC2 4.2879 6.0459 1.0169 0.2693
OAW28 GDSC2 4.4723 6.5608 0.9036 0.4467
OVCAR-5 GDSC2 4.5355 7.1247 0.7209 0.9292
OVCAR-4 GDSC2 4.9318 7.0769 0.8926 0.3128
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PaTu 8988t GDSC2 2.312 12.3591 -3.2088 24.0762
DAN-G GDSC2 2.8576 5.8603 0.3919 5.4526
Panc 02.03 GDSC2 3.0357 9.2935 -1.1373 12.9339
YAPC GDSC2 3.0807 4.9469 0.9262 1.3518
MIA PaCa-2 GDSC2 3.1573 4.6121 1.0959 0.591
KP-4 GDSC2 3.4001 4.866 1.1009 0.4267
AsPC-1 GDSC2 3.4323 5.5451 0.8505 1.5821
SU.86.86 GDSC2 3.4706 4.8714 1.1267 0.3239
Panc 10.05 GDSC2 3.6043 10.5142 -1.3294 12.6513
PL4 GDSC2 3.6368 5.8498 0.8232 1.4861
PaTu 8902 GDSC2 3.6571 5.0375 1.138 0.2287
PSN1 GDSC2 3.6814 6.0445 0.7655 1.4365
HPAF-II GDSC2 3.6941 6.1362 0.7342 1.5579
KP-2 GDSC2 3.7068 4.8562 1.2178 0.0901
QGP-1 GDSC2 3.7848 5.3619 1.0709 0.3285
HPAC GDSC2 3.9019 5.6297 1.0195 0.4039
Capan-1 GDSC2 3.9283 5.5384 1.0622 0.2945
BxPC-3 GDSC2 3.9285 5.8769 0.9393 0.6117
HuP-T3 GDSC2 3.9566 6.0422 0.8888 0.7524
SUIT-2 GDSC2 3.9938 5.585 1.0701 0.2565
Capan-2 GDSC2 4.1249 6.9992 0.5876 1.7592
CFPAC-1 GDSC2 4.1312 5.8136 1.0406 0.3256
Panc 08.13 GDSC2 4.2678 6.5958 0.8093 0.8132
KP-3 GDSC2 4.3205 6.4805 0.8736 0.5922
HuP-T4 GDSC2 4.8086 6.6224 1.0045 0.1652
KP-1N GDSC2 4.9077 6.5731 1.0549 0.1132
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MSTO-211H GDSC2 1.9746 5.0636 0.1588 7.9496
MPP 89 GDSC2 2.9839 4.9696 0.8672 1.7487
NCI-H2052 GDSC2 3.8789 5.4736 1.0667 0.3024
IST-Mes1 GDSC2 4.1987 6.199 0.9285 0.5034
NCI-H28 GDSC2 4.3928 6.3207 0.9591 0.3518
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LNCaP clone FGC GDSC2 -2.4319 1.6171 -2.8076 41.5714
VCaP GDSC2 1.8197 4.9027 0.1174 8.6216
22Rv1 GDSC2 2.2048 5.5893 0.073 7.899
PC-3 GDSC2 3.0582 11.9151 -2.4096 19.0159
DU145 GDSC2 4.5227 6.3361 1.0013 0.2323
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC2 2.4037 4.7208 0.6357 4.0047
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A2058 GDSC2 1.9094 3.2002 1.0292 2.6801
HT-144 GDSC2 2.1874 7.0782 -0.6771 12.471
IGR-37 GDSC2 2.2576 4.2363 0.7693 3.5053
WM793 GDSC2 2.35 4.1821 0.8551 2.8126
UACC-62 GDSC2 2.5193 6.4337 -0.1117 8.2723
SK-MEL-24 GDSC2 2.6117 6.1779 0.0776 6.9209
A101D GDSC2 2.6292 6.2164 0.0712 6.9213
SK-MEL-2 GDSC2 2.6844 6.5726 -0.0627 7.6018
CHL-1 GDSC2 2.7296 5.1294 0.6515 3.294
WT2-iPS GDSC2 2.7614 7.1003 -0.2645 8.6295
HMV-II GDSC2 2.7688 5.3217 0.5868 3.593
RPMI-7951 GDSC2 2.8367 13.885 -3.5556 23.9352
M14 GDSC2 3.0055 5.4933 0.6492 2.8504
WM1552C GDSC2 3.024 5.8298 0.5081 3.5948
CP66-MEL GDSC2 3.0565 5.2585 0.7811 2.0842
SK-MEL-5 GDSC2 3.2079 4.7025 1.0829 0.6009
IGR-1 GDSC2 3.4263 5.2284 0.9741 0.8288
Mel JuSo GDSC2 3.4476 5.143 1.0164 0.6633
COLO 829 GDSC2 3.4987 7.7203 -0.0724 6.0205
COLO 679 GDSC2 3.516 5.3526 0.9651 0.7937
WM35 GDSC2 3.546 6.5553 0.4811 2.9418
GAK GDSC2 3.5726 5.0501 1.1016 0.3422
G-mel GDSC2 3.706 5.3045 1.0612 0.3852
G-361 GDSC2 3.8458 5.7523 0.9521 0.7445
COLO 792 GDSC2 3.9266 5.8092 0.9636 0.6501
LOX-IMVI GDSC2 3.9667 5.3985 1.1249 0.167
SH-4 GDSC2 3.9973 5.9655 0.9342 0.5887
UACC-257 GDSC2 4.1324 5.7413 1.0662 0.2233
A-375 GDSC2 4.4779 5.8285 1.1561 0.0555
WM278 GDSC2 4.8192 6.8172 0.9418 0.2567
WM115 GDSC2 4.8745 14.5423 -2.3998 14.9961
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC2 3.0138 7.2588 -0.1677 7.5125
Cancer Drug Sensitivity Data Curated from 18 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Rh41 GDSC2 -1.5166 1.7809 -1.8554 32.7653
Rh30 GDSC2 2.172 5.8907 -0.1004 10.7906
SW684 GDSC2 2.2625 6.8253 -0.4942 11.1977
G-401 GDSC2 2.3387 10.8983 -2.4594 23.8215
MES-SA GDSC2 2.7824 6.8132 -0.1111 7.674
G-402 GDSC2 2.8211 5.777 0.4078 4.5293
GCT GDSC2 3.0439 9.5924 -1.2775 15.8255
KYM-1 GDSC2 3.1082 6.2621 0.3609 4.276
SK-UT-1 GDSC2 3.1893 6.1849 0.4445 3.6737
RKN GDSC2 3.2212 4.5496 1.1461 0.3921
SW982 GDSC2 3.2304 5.7469 0.6625 2.4508
EW-8 GDSC2 3.3993 5.1234 1.0031 0.7436
VA-ES-BJ GDSC2 3.5108 5.2541 1.0007 0.8083
SW872 GDSC2 3.5752 6.7605 0.4072 3.2816
HT-1080 GDSC2 3.6044 5.0075 1.129 0.3188
RD GDSC2 4.0746 9.8921 -0.7225 9.9745
SK-LMS-1 GDSC2 4.3029 6.015 1.033 0.2354
A-204 GDSC2 4.5266 7.4983 0.5728 1.7486
⏷ Show the Full List of 18 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IM95 GDSC2 -0.2501 3.3229 -1.0615 22.8796
HGC-27 GDSC2 -0.1061 6.167 -2.2325 28.0444
AGS GDSC2 1.2904 8.6594 -2.2006 23.0066
RERF-GC-1B GDSC2 1.7575 4.3859 0.3255 7.4839
NCI-N87 GDSC2 1.794 6.3429 -0.6221 13.2264
23132/87 GDSC2 1.8301 7.3536 -1.0977 15.8552
MKN45 GDSC2 2.0584 8.0239 -1.2489 16.0361
SNU-5 GDSC2 2.3545 5.8633 0.0483 7.6881
KATO III GDSC2 2.4919 7.2557 -0.5347 10.8589
OCUM-1 GDSC2 2.5228 6.081 0.0625 7.211
Hs 746.T GDSC2 2.5611 14.796 -4.2257 26.7185
RF-48 GDSC2 2.8218 7.8754 -0.5985 10.4404
GCIY GDSC2 2.9509 5.275 0.7156 2.5775
MKN1 GDSC2 3.0496 10.7431 -1.8382 16.4517
SK-GT-2 GDSC2 3.3523 6.3048 0.4843 3.2039
NUGC-4 GDSC2 3.5452 5.609 0.8774 1.1023
ECC10 GDSC2 4.1309 5.9075 1.0074 0.3408
NUGC-3 GDSC2 4.1919 5.7611 1.0807 0.2206
SNU-1 GDSC2 4.3628 6.1583 1.005 0.2693
MKN28 GDSC2 4.6019 6.8736 0.8408 0.546
SNG-M GDSC2 3.642 5.8969 0.8067 1.3017
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 12 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
K5 GDSC2 2.3498 6.7427 -0.3876 10.3406
ASH-3 GDSC2 2.4466 7.572 -0.7243 14.2124
CAL-62 GDSC2 3.3792 4.8669 1.0921 0.4639
FTC-133 GDSC2 3.6208 9.7031 -0.9285 10.5159
BHT-101 GDSC2 3.6666 5.0993 1.1198 0.2633
IHH-4 GDSC2 3.7011 4.9727 1.1764 0.1481
WRO GDSC2 3.9651 5.7329 1.0066 0.4086
8305C GDSC2 4.0418 5.6298 1.072 0.2383
B-CPAP GDSC2 4.1079 5.456 1.1547 0.1
8505C GDSC2 4.2008 5.9918 1.0037 0.3239
TT2609-C02 GDSC2 4.4769 6.3054 0.9954 0.2546
HTC-C3 GDSC2 4.8044 6.7575 0.957 0.2824
⏷ Show the Full List of 12 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
UPCI-SCC-090 GDSC2 -0.5153 5.8117 -2.4595 30.6243
BB49-HNC GDSC2 1.698 8.9896 -2.0236 20.9598
DOK GDSC2 1.9453 5.8131 -0.2368 10.4784
HSC-2 GDSC2 1.9514 4.5899 0.3759 6.6514
Detroit 562 GDSC2 2.1452 5.5684 0.0387 9.8693
BICR 10 GDSC2 2.442 11.4206 -2.6382 21.5449
HO-1-N-1 GDSC2 2.5204 4.9794 0.5897 4.0435
CAL-33 GDSC2 2.6139 7.197 -0.4166 11.6869
SAT [Human HNSCC] GDSC2 2.7041 7.8759 -0.6836 11.2067
PCI-04B GDSC2 2.8216 5.7095 0.4397 4.3432
HSC-4 GDSC2 2.8392 7.1753 -0.2466 8.3504
SCC-9 GDSC2 2.8465 6.0273 0.3065 5.0713
BICR 22 GDSC2 2.966 7.2729 -0.2066 7.8408
JHU-022 GDSC2 3.0694 9.159 -1.0475 12.3721
SCC-4 GDSC2 3.4728 6.9352 0.2713 4.162
SAS GDSC2 3.4741 6.1954 0.5986 2.4457
FaDu GDSC2 3.5617 6.1084 0.6808 1.9413
NCI-H3118 GDSC2 3.6302 7.1088 0.2838 3.8486
CAL-27 GDSC2 3.6539 5.0574 1.1298 0.2958
SKN-3 GDSC2 3.7043 6.1851 0.7191 1.6132
Ca9-22 GDSC2 3.7289 5.8134 0.8791 0.9449
HSC-3 GDSC2 3.8888 5.9315 0.9024 0.7516
BICR 78 GDSC2 3.9816 5.8356 0.9758 0.4807
LB771-HNC GDSC2 4.0276 6.1611 0.8735 0.7572
OSC-20 GDSC2 4.0346 6.3144 0.8179 0.9386
SCC-15 GDSC2 4.0373 6.3198 0.817 0.9399
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 13 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CAL-29 GDSC2 2.1747 7.3355 -0.8148 15.6427
KU-19-19 GDSC2 2.4994 5.7386 0.212 6.3572
TCCSUP GDSC2 2.7483 5.6315 0.4296 4.5412
BFTC-905 GDSC2 2.7961 4.3441 1.0362 1.1655
HT-1197 GDSC2 2.8867 8.964 -1.0839 13.0003
RT-112 GDSC2 3.0926 7.2706 -0.1209 7.078
639V GDSC2 3.2799 4.5809 1.1579 0.33
647V GDSC2 3.4271 4.6859 1.1764 0.2263
J82 GDSC2 3.52 5.7587 0.8052 1.4262
SW1710 GDSC2 3.5353 5.949 0.7342 1.7251
RT-4 GDSC2 3.76 6.4319 0.6444 1.886
SW780 GDSC2 4.2646 6.122 0.9814 0.3491
5637 GDSC2 4.4745 6.1422 1.0505 0.1674
⏷ Show the Full List of 13 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PA-1 GDSC2 -0.7106 3.0146 -1.4165 26.7603
ME-180 GDSC2 0.8288 7.3372 -1.9433 26.8807
C-33 A GDSC2 1.3243 6.857 -1.2713 18.327
NEC8 GDSC2 2.6142 4.2876 0.9644 1.7594
OVCA420 GDSC2 2.6994 4.8636 0.7549 2.7635
HeLa GDSC2 2.7338 4.1577 1.0829 1.2245
HEC-1 GDSC2 2.781 4.9303 0.7726 2.5333
PEO1 GDSC2 2.826 5.1415 0.7036 2.8392
BPH-1 GDSC2 2.8895 7.7246 -0.4773 9.5859
DoTc2 4510 GDSC2 2.9048 7.756 -0.4818 9.5773
SW756 GDSC2 2.9611 4.6126 1.006 1.1213
DSH1 GDSC2 3.0551 6.0379 0.4317 3.9695
Ca Ski GDSC2 3.2064 7.0836 0.0409 5.9201
CAL-39 GDSC2 3.2137 6.7563 0.1977 5.012
LB831-BLC GDSC2 3.3209 6.6316 0.3195 4.1455
SiHa GDSC2 3.3599 4.8595 1.087 0.4904
PWR-1E GDSC2 3.5422 6.3442 0.5705 2.4964
SKN GDSC2 3.6038 6.8768 0.3718 3.4245
SKG-IIIa GDSC2 3.6421 4.9892 1.1494 0.211
C-4-I GDSC2 3.9133 5.6859 1.0036 0.4395
TC-YIK GDSC2 3.9182 5.8025 0.9628 0.5486
MS751 GDSC2 3.997 6.3629 0.7828 1.0929
SiSo GDSC2 4.0092 6.5408 0.7181 1.3303
OVMIU GDSC2 4.3086 8.3285 0.1212 3.7182
HT-3 GDSC2 4.4316 6.0189 1.0772 0.1675
HEY GDSC2 4.4792 6.2762 1.0063 0.2819
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug

References

1 ClinicalTrials.gov (NCT01445587) A Study of GSK2110183 in Subjects With Proteasome Inhibitor Refractory Multiple Myeloma. U.S. National Institutes of Health.
2 ClinicalTrials.gov (NCT01531894) Continuation Study of the Oral AKT Inhibitor GSK2110183. U.S. National Institutes of Health.
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7890).
4 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1479).
5 Novel ATP-competitive Akt inhibitor afuresertib suppresses the proliferation of malignant pleural mesothelioma cells. Cancer Med. 2017 Nov;6(11):2646-2659. doi: 10.1002/cam4.1179. Epub 2017 Sep 27.