Details of the Drug

General Information of Drug (ID: DMZKPI8)

Drug Name
TAK-715
Synonyms P38 MAP kinase inhibitor (rheumatoid arthritis), Takeda
Indication
Disease Entry ICD 11 Status REF
Rheumatoid arthritis FA20 Phase 2 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 1 Molecular Weight (mw) 399.5
Logarithm of the Partition Coefficient (xlogp) 5.6
Rotatable Bond Count (rotbonds) 5
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 4
Chemical Identifiers
Formula
C24H21N3OS
IUPAC Name
N-[4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]pyridin-2-yl]benzamide
Canonical SMILES
CCC1=NC(=C(S1)C2=CC(=NC=C2)NC(=O)C3=CC=CC=C3)C4=CC=CC(=C4)C
InChI
InChI=1S/C24H21N3OS/c1-3-21-27-22(18-11-7-8-16(2)14-18)23(29-21)19-12-13-25-20(15-19)26-24(28)17-9-5-4-6-10-17/h4-15H,3H2,1-2H3,(H,25,26,28)
InChIKey
HEKAIDKUDLCBRU-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
9952773
ChEBI ID
CHEBI:91360
CAS Number
303162-79-0
UNII
WE92U03C5Z
DrugBank ID
DB16108
TTD ID
D0O6ZO
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Stress-activated protein kinase (p38) TTWELHI NOUNIPROTAC Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Forkhead box protein O3 (FOXO3) OTHXQG4P FOXO3_HUMAN Gene/Protein Processing [3]
NAD-dependent protein deacylase sirtuin-6 (SIRT6) OTF755ZO SIR6_HUMAN Gene/Protein Processing [3]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1 4.6774 6.3182 3.6023 4.51
ES5 GDSC1 2.9997 9.7656 0.4325 31.6571
EW-13 GDSC1 3.2098 6.6901 2.119 21.6165
NOS-1 [Human HNSCC] GDSC1 3.5455 5.3998 3.0508 13.2419
EW-1 GDSC1 3.6904 10.7407 0.5721 28.0972
ES7 GDSC1 3.7622 14.5197 -1.2506 33.9098
ES4 GDSC1 3.794 13.3105 -0.6196 32.0515
ES8 GDSC1 3.9093 5.2386 3.4866 8.252
TC-71 GDSC1 3.9116 5.7429 3.246 10.0973
EW-18 GDSC1 3.9175 10.9439 0.6682 26.7602
MHH-ES-1 GDSC1 3.9179 18.4846 -3.0988 37.1243
ES1 GDSC1 3.935 15.7303 -1.7079 34.4232
HuO9 GDSC1 4.1311 5.4239 3.6048 6.3868
EW-24 GDSC1 4.333 5.1516 3.9163 3.1593
CADO-ES1 GDSC1 4.3354 5.6194 3.6844 4.9796
SK-ES-1 GDSC1 4.4335 5.6651 3.7408 4.1945
EW-16 GDSC1 4.4414 6.1833 3.4889 6.1497
EW-7 GDSC1 4.4677 13.834 -0.3132 28.6792
A-673 GDSC1 4.4918 5.7336 3.7521 3.915
SK-PN-DW GDSC1 4.5269 6.361 3.4678 6.029
EW-3 GDSC1 4.9794 7.1782 3.3977 5.2221
SJSA-1 GDSC1 5.3596 7.1804 3.6368 2.6045
CHSA8926 GDSC1 5.9062 7.8515 3.6372 1.7093
CAL-72 GDSC1 5.9201 7.3244 3.8532 0.6299
HOS GDSC1 6.0047 7.5959 3.7854 0.8455
NY GDSC1 6.2135 9.136 3.2486 3.2011
MG-63 GDSC1 6.451 8.2022 3.7424 0.6662
CAL-78 GDSC1 6.5491 8.2269 3.7722 0.4489
SaOS-2 GDSC1 6.7163 8.3143 3.8044 0.3318
ES6 GDSC1 6.9579 14.362 1.2922 14.1079
G-292 clone A141B1 GDSC1 7.0086 8.4079 3.8758 0.1038
U2OS GDSC1 7.0089 14.7244 1.1536 14.7241
CHSA0108 GDSC1 7.0184 8.9137 3.7053 0.4632
H-EMC-SS GDSC1 7.0794 9.2273 3.6156 0.7068
HuO-3N1 GDSC1 7.2547 8.9111 3.7917 0.1907
CHSA0011 GDSC1 7.6104 9.5717 3.6921 0.2768
EW-11 GDSC1 7.9169 10.1521 3.602 0.3658
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 146 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC1 4.1511 5.6816 3.495 7.1678
ATN-1 GDSC1 0.1289 3.6396 -0.0874 52.0469
MOLT-16 GDSC1 0.3855 3.509 0.2175 49.2952
ALL-SIL GDSC1 0.5327 2.4867 0.5079 47.424
THP-1 GDSC1 1.5083 5.9179 0.705 38.8651
CTV-1 GDSC1 1.5285 3.9164 1.3737 35.8075
WIL2 NS GDSC1 1.5578 4.1505 1.3504 35.731
RPMI-8402 GDSC1 1.5804 3.9951 1.4125 35.2439
Karpas-45 GDSC1 1.6559 4.7221 1.2941 35.3551
SU-DHL-10 GDSC1 1.7134 2.9312 1.7035 32.6688
EB2 GDSC1 1.8829 4.0572 1.7275 31.4524
SUP-B15 GDSC1 2.1758 7.2446 0.8342 34.2198
697 GDSC1 2.2673 5.3473 1.735 29.0732
MOLP-8 GDSC1 2.2864 11.7827 -1.216 39.5301
KE-37 GDSC1 2.3432 3.3932 2.3282 24.8284
Loucy GDSC1 2.3724 3.3652 2.3604 24.4447
QIMR-WIL GDSC1 2.5965 5.564 1.9981 25.5573
NK-92MI GDSC1 2.9289 5.1554 2.5141 20.2505
HAL-01 GDSC1 2.9355 9.8945 0.3099 32.423
VL51 GDSC1 3.045 6.9438 1.8384 24.265
Kasumi-1 GDSC1 3.0905 11.1909 -0.186 33.4607
RL GDSC1 3.2967 5.757 2.6382 17.4999
RPMI-6666 GDSC1 3.3277 5.4354 2.8134 16.0599
DB GDSC1 3.3801 6.2584 2.4889 18.198
A3/Kawakami GDSC1 3.4016 9.9883 0.6894 28.7898
MOLM-13 GDSC1 3.4038 12.6877 -0.6488 33.5998
OCI-M1 GDSC1 3.4093 9.5978 0.8895 27.8334
BL-41 GDSC1 3.4252 5.5634 2.8555 15.2753
SIG-M5 GDSC1 3.5016 4.111 3.4742 10.4293
BE-13 GDSC1 3.5075 5.9734 2.7477 15.695
P12-Ichikawa GDSC1 3.5258 6.494 2.5175 17.3215
SU-DHL-6 GDSC1 3.5409 4.4395 3.4348 10.4684
SU-DHL-5 GDSC1 3.5434 4.1963 3.503 9.9932
CTB-1 GDSC1 3.5675 5.3672 3.0878 12.8597
ST486 GDSC1 3.5884 5.2955 3.1413 12.3594
Farage GDSC1 3.5916 4.8042 3.356 10.7571
MEG-01 GDSC1 3.6551 8.4748 1.6665 22.5372
A4/Fukuda GDSC1 3.6556 14.5498 -1.3573 34.5421
MOLT-13 GDSC1 3.6672 4.6143 3.5107 9.2506
EoL-1 GDSC1 3.6889 9.3579 1.2587 24.7494
BALL-1 GDSC1 3.7128 5.0336 3.3847 9.9416
PL-21 GDSC1 3.7476 8.9363 1.5202 23.0229
SUP-HD1 GDSC1 3.7549 5.1266 3.3857 9.7317
YT GDSC1 3.7578 5.6376 3.1502 11.5078
SU-DHL-16 GDSC1 3.76 4.3209 3.709 7.359
Ku812 GDSC1 3.7632 5.7998 3.0779 12.0378
CA46 GDSC1 3.7638 7.1693 2.41 17.0712
NU-DUL-1 GDSC1 3.7645 4.6802 3.5886 8.182
SUP-M2 GDSC1 3.7885 4.3966 3.7178 7.1379
MV4-11 GDSC1 3.792 4.4132 3.7163 7.1288
BV-173 GDSC1 3.8189 4.4496 3.7335 6.8615
Mono-Mac-6 GDSC1 3.8428 5.3932 3.3487 9.6071
WSU-DLCL2 GDSC1 3.843 4.2609 3.8145 6.1716
RPMI-8866 GDSC1 3.8509 4.5361 3.7368 6.6654
KMS-12-BM GDSC1 3.853 4.4175 3.7812 6.3418
NALM-6 GDSC1 3.8594 4.9792 3.5579 7.9407
Sc-1 GDSC1 3.8642 4.4419 3.7852 6.252
KOPN-8 GDSC1 3.8648 4.4929 3.7678 6.3718
SU-DHL-1 GDSC1 3.8686 4.762 3.6635 7.1084
OCI-Ly19 GDSC1 3.8727 4.4751 3.7827 6.2237
P32/ISH GDSC1 3.8734 4.4166 3.8036 6.0735
Hs 445 GDSC1 3.8804 4.9565 3.5893 7.6046
HC-1 GDSC1 3.8832 4.5532 3.7648 6.2955
Namalwa GDSC1 3.8862 6.8473 2.68 14.5572
SR GDSC1 3.8874 4.9122 3.6164 7.3682
P30/OHK GDSC1 3.9005 12.4364 -0.0916 29.9101
PF-382 GDSC1 3.909 8.1712 2.0432 19.0441
MN-60 GDSC1 3.9228 8.0938 2.0938 18.6444
LC4-1 GDSC1 3.9259 11.5843 0.3556 28.0861
Ramos.2G6.4C10 GDSC1 3.9337 4.4449 3.8593 5.3549
RS4;11 GDSC1 3.9386 5.0911 3.5848 7.3685
OPM-2 GDSC1 3.946 4.8941 3.6836 6.5846
LP-1 GDSC1 3.9482 4.6384 3.7989 5.7141
SUP-T1 GDSC1 3.955 11.9732 0.1864 28.6582
KG-1 GDSC1 3.9584 4.7352 3.7676 5.8954
Daudi GDSC1 3.9667 4.6529 3.8119 5.5262
L-363 GDSC1 3.9708 4.4996 3.8789 5.0182
MOLT-4 GDSC1 3.9869 5.9705 3.2041 10.1064
HEL GDSC1 3.9913 9.75 1.3276 23.1297
ALL-PO GDSC1 4.0097 12.8514 -0.2057 29.9117
SK-MM-2 GDSC1 4.018 5.398 3.5135 7.5693
SU-DHL-8 GDSC1 4.0303 18.6271 -3.0751 36.7649
CESS GDSC1 4.0345 5.0068 3.718 5.9172
JJN-3 GDSC1 4.0404 4.6885 3.872 4.7199
MY-M12 GDSC1 4.0446 6.4619 3.0128 11.3625
LAMA-84 GDSC1 4.0527 12.6876 -0.0873 29.3312
NKM-1 GDSC1 4.0685 6.2738 3.1275 10.3743
AMO1 GDSC1 4.0832 5.2874 3.6282 6.4018
ML-2 GDSC1 4.0846 5.1895 3.6773 6.0143
DND-41 GDSC1 4.0925 5.8957 3.3365 8.6433
MHH-PREB-1 GDSC1 4.0989 4.9085 3.827 4.7939
RC-K8 GDSC1 4.1004 5.304 3.6359 6.2697
DEL GDSC1 4.1072 4.6096 3.9751 3.6269
GR-ST GDSC1 4.1135 5.5693 3.5171 7.1451
TK [Human B-cell lymphoma] GDSC1 4.1156 4.9177 3.8384 4.6327
L-540 GDSC1 4.1164 10.4229 1.0985 23.8777
TUR GDSC1 4.1372 5.8516 3.3981 7.983
SCC-3 GDSC1 4.142 4.9203 3.8622 4.3349
MLMA GDSC1 4.1424 5.5556 3.5497 6.773
ARH-77 GDSC1 4.1458 5.067 3.794 4.8484
RPMI-8226 GDSC1 4.146 6.0488 3.3078 8.6579
U-698-M GDSC1 4.1534 5.2437 3.714 5.4416
Granta-519 GDSC1 4.1587 8.2015 2.2445 16.6618
HH [Human lymphoma] GDSC1 4.1724 5.5282 3.59 6.3377
KCL-22 GDSC1 4.1756 5.3352 3.6887 5.551
Karpas-299 GDSC1 4.1832 6.8737 2.9287 11.4762
DG-75 GDSC1 4.2338 6.9172 2.9502 11.1182
K-562 GDSC1 4.2425 9.833 1.4999 21.1616
KM-H2 GDSC1 4.274 5.5444 3.6703 5.3152
CCRF-CEM GDSC1 4.2819 5.3323 3.783 4.3971
NB4 GDSC1 4.3236 5.0336 3.9675 2.7891
BC-3 GDSC1 4.3287 5.7409 3.6181 5.5266
EM-2 GDSC1 4.334 5.7787 3.6036 5.6216
EJM GDSC1 4.3571 6.7702 3.127 9.2883
VAL GDSC1 4.3817 12.4374 0.3139 26.5707
MC116 GDSC1 4.3828 5.2199 3.9226 2.9359
OCI-AML-2 GDSC1 4.3988 5.5462 3.7726 4.0616
WSU-NHL GDSC1 4.4141 5.7898 3.6633 4.8697
KMOE-2 GDSC1 4.456 8.8674 2.1599 16.1385
KMS-11 GDSC1 4.4726 5.6813 3.7634 3.8889
KY821 GDSC1 4.4755 5.6067 3.8026 3.5723
HDLM-2 GDSC1 4.5278 8.458 2.4228 14.022
JSC-1 GDSC1 4.5327 17.8838 -2.2842 33.8533
Raji GDSC1 4.5364 5.7116 3.7967 3.427
Jiyoye GDSC1 4.588 5.9472 3.7189 3.8745
HL-60 GDSC1 4.6013 5.9691 3.718 3.8418
HT GDSC1 4.6113 5.7685 3.8234 2.9996
NOMO-1 GDSC1 4.6536 8.4338 2.5355 12.7639
JVM-2 GDSC1 4.6674 6.6396 3.4369 5.8232
Karpas-422 GDSC1 4.6748 6.6271 3.4486 5.71
P31/FUJ GDSC1 4.6754 5.8576 3.8249 2.8096
JURL-MK1 GDSC1 4.6868 7.5155 3.0181 9.0109
L-428 GDSC1 4.9171 8.8586 2.5285 11.9449
H9 GDSC1 4.9355 7.712 3.1071 7.5571
OCI-AML-5 GDSC1 5.0294 12.8677 0.6234 22.9826
GDM-1 GDSC1 5.0637 13.3787 0.3959 23.9026
JVM-3 GDSC1 5.0918 8.2344 2.9643 8.1817
OCI-AML-3 GDSC1 5.1433 8.6227 2.8117 9.1701
SU-DHL-4 GDSC1 5.2188 6.861 3.6991 2.4594
BC-1 GDSC1 5.281 15.2595 -0.3696 26.2781
ROS-50 GDSC1 5.5638 12.1459 1.3905 17.3183
L-1236 GDSC1 5.7341 8.1844 3.4019 3.4585
ME1 GDSC1 5.7346 6.7493 3.9911 0.2648
Karpas-620 GDSC1 5.847 17.1364 -0.8629 26.3448
Reh GDSC1 6.0546 17.3141 -0.7927 25.5469
U266B1 GDSC1 6.8071 8.4422 3.793 0.3241
⏷ Show the Full List of 146 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE-12 GDSC1 3.4706 7.1368 2.1545 20.1637
ESO-26 GDSC1 3.8998 6.5693 2.8296 13.3632
OACP4 C GDSC1 3.957 9.6128 1.3665 23.0486
OACM5.1 C GDSC1 4.0204 10.578 0.9392 25.0646
KYAE-1 GDSC1 4.2426 12.7061 0.0636 28.0761
HCE-4 GDSC1 4.639 7.1789 3.1483 8.1589
FLO-1 GDSC1 4.8125 10.3091 1.7267 17.7259
ESO-51 GDSC1 5.1263 8.1954 3.0077 7.7577
SK-GT-4 GDSC1 5.8863 8.2442 3.46 2.805
KYSE-50 GDSC1 6.0496 7.6005 3.8028 0.732
KYSE-220 GDSC1 8.758 22.0108 -1.1546 20.4924
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1 4.4581 6.4811 3.3536 7.1563
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-N-MC-IXC GDSC1 3.0896 4.3975 2.9557 16.2879
IMR-5 GDSC1 3.7134 5.0701 3.3691 10.0547
NH-12 GDSC1 3.9924 6.0721 3.1591 10.435
SJNB-7 GDSC1 4.0296 6.3925 3.034 11.2582
KP-N-YS GDSC1 4.0525 6.0449 3.2267 9.6632
Kelly GDSC1 4.133 5.4034 3.6167 6.2861
SJNB-12 GDSC1 4.2144 5.8158 3.4836 7.0117
SJNB-14 GDSC1 4.3482 5.5628 3.7233 4.6272
MHH-NB-11 GDSC1 4.3702 7.2477 2.8991 11.0131
LA-N-6 GDSC1 4.6186 6.1508 3.6414 4.3839
SK-N-FI GDSC1 4.6602 7.0325 3.2372 7.3992
SJNB-10 GDSC1 4.762 8.0958 2.788 10.5216
CHP-212 GDSC1 4.7867 7.9944 2.8572 9.9193
SK-N-AS GDSC1 4.7868 6.3185 3.6795 3.6098
SJNB-13 GDSC1 4.789 6.9222 3.3875 5.8389
GI-ME-N GDSC1 4.7914 7.013 3.3448 6.161
TGW GDSC1 4.8514 8.1283 2.84 9.8434
SiMa GDSC1 4.9588 7.9139 3.0251 8.1124
SK-N-DZ GDSC1 5.0468 9.4746 2.3219 13.0055
SK-N-SH GDSC1 5.0714 7.5893 3.2628 5.9905
NB(TU)1 GDSC1 5.1353 7.5665 3.3172 5.4122
NB69 GDSC1 5.2463 7.0159 3.6451 2.7746
SK-N-BE(2)-M17 GDSC1 5.2807 8.7369 2.8534 8.4696
KP-N-YN GDSC1 5.3441 8.311 3.1015 6.4705
SJNB-5 GDSC1 5.587 7.5598 3.5961 2.4536
CHP-134 GDSC1 5.6218 6.9628 3.8637 0.8568
GOTO GDSC1 5.8137 7.9547 3.5464 2.3848
SJNB-6 GDSC1 5.9111 8.0413 3.5601 2.1497
SJNB-17 GDSC1 6.0937 9.009 3.2383 3.8627
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC1 4.8427 7.3912 3.1968 7.1472
Cancer Drug Sensitivity Data Curated from 51 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCC1500 GDSC1 3.5568 5.8223 2.2861 7.7355
OCUB-M GDSC1 3.7253 10.8299 0.5583 28.0159
DU4475 GDSC1 3.8714 4.6607 3.7092 6.7591
HCC2218 GDSC1 3.8812 9.1192 1.5468 22.3114
MDA-MB-468 GDSC1 3.9387 5.031 3.6131 6.3826
HCC202 GDSC1 4.1723 6.132 3.2894 8.7004
CAMA-1 GDSC1 4.2221 5.6614 3.5673 5.6419
HCC1806 GDSC1 4.245 6.6295 3.1034 8.8229
HCC1187 GDSC1 4.2491 7.0773 2.8831 11.5804
BT-474 GDSC1 4.2899 7.2212 2.8455 11.7181
MDA-MB-453 GDSC1 4.348 6.1922 3.4084 6.3444
HCC1954 GDSC1 4.3573 7.1313 2.9466 9.5531
MFM-223 GDSC1 4.3741 5.4937 3.7789 4.0976
BT-549 GDSC1 4.3749 5.5345 3.7592 3.7922
BT-20 GDSC1 4.4907 5.5975 3.8187 3.0321
CAL-148 GDSC1 4.5354 6.4179 3.4461 6.1718
Evsa-T GDSC1 4.55 5.8855 3.7211 3.974
HCC1419 GDSC1 4.5586 5.9779 3.6819 3.7945
COLO 824 GDSC1 4.6112 6.4084 3.5088 5.4381
MCF-7 GDSC1 4.658 6.3625 3.5664 4.3242
UACC-893 GDSC1 4.7021 6.2385 3.659 3.5705
MDA-MB-175-VII GDSC1 4.7729 6.2663 3.6951 3.1492
AU565 GDSC1 4.7874 6.8364 3.4284 4.9337
JIMT-1 GDSC1 4.8035 6.1262 3.7827 2.4918
CAL-51 GDSC1 4.8061 6.5003 3.605 3.6784
HCC38 GDSC1 4.8289 6.8908 3.4316 4.8042
UACC-812 GDSC1 4.8863 6.6345 3.5955 3.9787
CAL-120 GDSC1 4.9404 6.7888 3.5581 3.6744
HCC1937 GDSC1 4.9694 6.8048 3.5698 3.5297
HCC1569 GDSC1 4.9867 9.1864 2.4191 12.5098
HCC2157 GDSC1 5.0767 7.4558 3.3306 5.4658
HCC1599 GDSC1 5.3116 9.151 2.6742 9.6916
YMB-1-E GDSC1 5.3545 8.0362 3.2387 5.4385
BT-483 GDSC1 5.3774 7.2331 3.6234 2.6598
HCC70 GDSC1 5.3987 10.2811 2.1851 11.6259
CAL-85-1 GDSC1 5.5085 14.4944 0.1876 21.8185
MDA-MB-415 GDSC1 5.702 7.7252 3.5861 2.0709
MDA-MB-436 GDSC1 5.7359 8.0092 3.4807 2.6201
EFM-19 GDSC1 5.8846 11.829 1.7775 14.0926
MDA-MB-361 GDSC1 5.9865 7.8454 3.6784 1.3836
HDQ-P1 GDSC1 5.9962 7.6252 3.7703 0.8221
MDA-MB-330 GDSC1 6.1819 8.2481 3.6072 1.5229
HCC1395 GDSC1 6.2 8.5025 3.5118 1.8004
MDA-MB-231 GDSC1 6.2518 8.5821 3.5042 1.7764
MRK-nu-1 GDSC1 6.3063 7.5101 3.9349 0.1806
HCC1428 GDSC1 6.4148 12.0424 2.0355 10.072
EFM-192A GDSC1 6.6576 8.5204 3.7077 0.6536
Hs 578T GDSC1 6.7658 8.9132 3.6052 0.963
MDA-MB-157 GDSC1 7.2277 9.2372 3.6691 0.4167
ZR-75-30 GDSC1 8.6289 20.8048 -0.6656 17.9844
T-47D GDSC1 9.8539 21.674 -0.2918 14.4216
⏷ Show the Full List of 51 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 54 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MOG-G-UVW GDSC1 3.8007 5.954 3.0392 12.171
H4 GDSC1 3.9753 4.7128 3.7948 5.6106
U-251MG GDSC1 4.1671 5.0641 3.815 4.5966
8-MG-BA GDSC1 4.2342 5.4274 3.6945 5.275
PFSK-1 GDSC1 4.4418 6.0051 3.578 5.4468
Hs 683 GDSC1 4.4696 5.3152 3.9424 2.2301
A-172 GDSC1 4.5757 7.4215 2.9782 9.6854
NMC-G1 GDSC1 4.5761 6.5937 3.3903 6.4754
ONS-76 GDSC1 4.6233 5.9287 3.7537 3.5007
AM-38 GDSC1 4.6656 6.2838 3.6106 4.481
YKG-1 GDSC1 4.6888 6.5764 3.4839 5.3929
SF295 GDSC1 4.7075 6.3528 3.6072 4.3844
M059J GDSC1 4.717 6.5528 3.5161 5.059
GB-1 GDSC1 4.7582 6.0629 3.7827 2.9081
Becker GDSC1 4.8019 8.0152 2.8584 9.8612
SF126 GDSC1 4.86 6.2492 3.7613 2.8103
SF539 GDSC1 4.8966 6.4569 3.687 3.2687
SW1783 GDSC1 4.9498 8.9508 2.5077 11.991
SK-MG-1 GDSC1 5.0478 6.6539 3.691 2.5692
Daoy GDSC1 5.0753 6.6459 3.7116 2.6722
GaMG GDSC1 5.1344 10.22 2.0196 14.7843
Onda 10 GDSC1 5.1809 7.4427 3.4062 4.637
DBTRG-05MG GDSC1 5.1825 7.1663 3.5369 3.6796
SF268 GDSC1 5.253 8.4396 2.9779 7.6265
D283 Med GDSC1 5.3064 8.4593 3.0051 7.2808
KS-1 [Human Krukenberg tumour] GDSC1 5.3429 7.7307 3.3747 4.4781
Onda 11 GDSC1 5.3807 7.6789 3.4223 4.0509
KNS-81-FD GDSC1 5.4404 8.2262 3.2046 5.4775
D-263MG GDSC1 5.4713 7.0609 3.7501 1.6802
LNZTA3WT4 GDSC1 5.5748 7.6118 3.5665 2.6674
D-423MG GDSC1 5.5813 7.969 3.4103 3.3072
LN-405 GDSC1 5.6147 8.5993 3.1406 5.5255
LN-229 GDSC1 5.6764 7.514 3.6633 1.8883
T98G GDSC1 5.6872 8.145 3.3926 3.6124
DK-MG GDSC1 5.8518 7.1765 3.8806 0.5736
U-87MG ATCC GDSC1 5.8884 7.6559 3.7089 1.3408
GI-1 GDSC1 5.9048 8.2517 3.4667 2.7316
KNS-42 GDSC1 5.9216 7.4074 3.8222 0.7586
LN-18 GDSC1 6.0226 7.3088 3.9004 0.3899
CAS-1 GDSC1 6.0504 7.5495 3.8225 0.6515
U-118MG GDSC1 6.0789 7.9274 3.6882 1.2283
KINGS-1 GDSC1 6.0885 7.9092 3.6998 1.1608
D-336MG GDSC1 6.1708 14.1705 0.8406 18.4957
SW1088 GDSC1 6.3274 8.4533 3.5922 1.4331
D-542MG GDSC1 6.3935 8.1094 3.7535 0.6648
YH-13 GDSC1 6.3981 7.7358 3.89 0.2206
KALS-1 GDSC1 6.4393 13.4393 1.3844 14.8997
MOG-G-CCM GDSC1 6.4933 14.4372 0.9397 17.1283
42-MG-BA GDSC1 6.5632 8.3223 3.743 0.5911
D-392MG GDSC1 6.5707 9.8914 3.1127 3.8254
SNB-75 GDSC1 6.6661 9.0906 3.493 1.5559
D-247MG GDSC1 6.7571 8.696 3.6828 0.6771
D-566MG GDSC1 7.1753 8.7392 3.8221 0.1601
D-502MG GDSC1 7.4431 9.1278 3.7839 0.1622
⏷ Show the Full List of 54 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TGBC24TKB GDSC1 4.9004 7.8003 3.0382 8.1878
ETK-1 GDSC1 4.94 9.4506 2.2527 13.8306
TGBC1TKB GDSC1 5.9491 7.9209 3.6295 1.695
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KLE GDSC1 4.3379 8.8411 2.0756 17.1506
AN3-CA GDSC1 4.6608 5.7781 3.8532 2.6344
ESS-1 GDSC1 5.1068 7.0729 3.5326 3.8894
RL95-2 GDSC1 5.232 7.1254 3.5864 3.215
EN GDSC1 5.504 8.8165 2.967 6.3031
MFE-319 GDSC1 5.5401 8.1519 3.3018 4.0632
MFE-296 GDSC1 6.2082 7.9886 3.7217 0.9425
MFE-280 GDSC1 6.5607 15.0581 0.6858 18.2047
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KTCTL-1M GDSC1 3.4269 5.4965 2.8873 15.0309
KTCTL-21 GDSC1 3.5368 5.7031 2.903 14.3931
KTCTL-140 GDSC1 3.6343 5.7914 2.9573 13.5349
769-P GDSC1 3.7436 6.2771 2.8286 12.5311
LB1047-RCC GDSC1 4.0997 8.7998 1.8953 17.4114
KTCTL-195 GDSC1 4.6248 7.2459 3.104 8.5489
786-O GDSC1 4.6553 8.3156 2.5957 11.0427
LB2241-RCC GDSC1 4.8307 6.2275 3.7525 2.6303
KTCTL-26A GDSC1 4.8393 7.9296 2.929 9.2073
SW13 GDSC1 4.8996 6.7143 3.5662 3.7157
HA7-RCC GDSC1 4.9088 6.6727 3.5923 3.5188
ACHN GDSC1 4.9251 11.6521 1.1465 19.0036
LB996-RCC GDSC1 5.0813 7.7914 3.172 5.9377
UO-31 GDSC1 5.1417 9.5273 2.3668 11.1607
RXF 393L GDSC1 5.356 7.6107 3.4386 3.561
A-498 GDSC1 5.3962 7.3069 3.6011 2.774
TK-10 GDSC1 5.3987 9.2742 2.6756 8.4679
BB65-RCC GDSC1 5.5964 7.2292 3.7428 1.3716
RCC10RGB GDSC1 5.6045 6.9929 2.9092 0.2219
KTCTL-13 GDSC1 5.6227 10.5345 2.2216 11.9725
BFTC-909 GDSC1 5.6964 7.6703 3.6068 2.2011
SN12C GDSC1 5.7113 10.0493 2.5171 8.7352
Caki-1 GDSC1 5.9616 12.3001 1.603 13.6359
KMRC-20 GDSC1 6.3191 8.6485 3.5095 1.6726
OS-RC-2 GDSC1 6.4657 13.3452 1.4477 13.2672
KMRC-1 GDSC1 6.4805 7.8676 3.8741 0.2542
SW156 GDSC1 6.5297 13.1468 1.5861 12.3662
A-704 GDSC1 6.7063 8.438 3.7567 0.467
VMRC-RCW GDSC1 6.9236 8.4524 3.8314 0.2043
CAL-54 GDSC1 7.0175 8.8377 3.7318 0.3925
NCC021 GDSC1 7.2471 8.7928 3.8288 0.1365
VMRC-RCZ GDSC1 9.3287 22.6556 -1.0834 18.1341
⏷ Show the Full List of 32 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 44 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CCK-81 GDSC1 3.2272 9.868 0.591 29.9823
CW-2 GDSC1 3.2296 8.8472 1.095 27.6273
SNU-175 GDSC1 3.4938 5.9727 2.7346 15.8564
HT115 GDSC1 3.6436 5.7368 2.9922 13.2274
NCI-H747 GDSC1 3.6852 8.9077 1.479 23.5269
RKO GDSC1 3.7642 9.2086 1.3995 23.6511
KM12 GDSC1 3.8798 6.5273 2.8322 13.4264
HCT 116 GDSC1 4.1142 4.9432 3.8248 4.7436
LS180 GDSC1 4.1834 5.5361 3.5959 6.2484
LS411N GDSC1 4.2515 5.4051 3.7206 5.0036
T84 GDSC1 4.368 5.6491 3.6963 4.7693
SNU-1040 GDSC1 4.4042 8.3556 2.3732 14.824
GP5d GDSC1 4.5315 6.0763 3.6127 4.8789
SNU-C2B GDSC1 4.5418 8.7782 2.2743 15.0336
HT-29 GDSC1 4.5823 5.9175 3.7293 3.811
HCC2998 GDSC1 4.674 6.3336 3.5923 4.5982
SW948 GDSC1 4.7266 7.5169 3.0479 8.6536
SNU-407 GDSC1 4.7693 7.6096 3.0344 8.621
NCI-H716 GDSC1 4.7755 8.6349 2.5308 12.3884
SW620 GDSC1 4.8182 8.4729 2.6441 11.4151
HCT 15 GDSC1 4.8245 6.6846 3.5287 4.6527
LS123 GDSC1 4.8538 7.4443 3.1788 7.2523
SNU-61 GDSC1 4.8568 7.3176 3.2431 6.7491
LS1034 GDSC1 4.8789 6.6172 3.5987 3.9738
SW1463 GDSC1 4.9762 6.4961 3.7197 2.8369
COLO205 GDSC1 4.9891 6.5927 3.6827 3.075
HT-55 GDSC1 5.0339 6.6329 3.6921 2.9031
COLO 320HSR GDSC1 5.0454 9.8613 2.1296 14.3334
SNU-C1 GDSC1 5.1682 10.7972 1.7597 16.3449
SW626 GDSC1 5.1897 8.7368 2.7892 9.2013
SW837 GDSC1 5.1917 9.0342 2.6454 10.2488
CaR-1 GDSC1 5.2161 8.5575 2.8951 8.3429
C2BBe1 GDSC1 5.3166 7.988 3.2368 5.5454
SW48 GDSC1 5.3229 10.5905 1.9777 14.4703
CL-11 GDSC1 5.375 8.4051 3.0772 6.5699
SNU-C5 GDSC1 5.4507 8.9721 2.857 7.9816
SNU-81 GDSC1 5.7887 12.0033 1.6244 15.2916
MDST8 GDSC1 6.2093 7.6257 3.8581 0.4201
LS513 GDSC1 6.2258 17.6204 -0.815 25.1656
SW1116 GDSC1 6.342 7.9772 3.7818 0.5966
SW1417 GDSC1 6.4288 8.145 3.7546 0.5682
COLO 678 GDSC1 6.9613 8.5726 3.8037 0.2473
LoVo GDSC1 7.0562 9.1946 3.6185 0.7113
RCM-1 [Human ESC] GDSC1 7.241 13.6305 1.817 10.5088
⏷ Show the Full List of 44 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1 3.4554 5.0338 3.1184 13.1826
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHH-4 GDSC1 3.1316 4.43 2.9919 14.1015
SNU-398 GDSC1 3.5909 6.3079 2.6691 15.9056
JHH-2 GDSC1 4.3765 5.2105 3.9222 2.6411
JHH-1 GDSC1 4.4489 9.5808 1.7976 16.8324
JHH-7 GDSC1 4.4987 6.7461 3.2538 6.9627
SNU-449 GDSC1 4.5114 8.1371 2.5699 13.0032
JHH-6 GDSC1 4.5881 5.9259 3.7295 3.7922
SK-HEP-1 GDSC1 4.9922 6.7425 3.6143 3.5689
SNU-423 GDSC1 5.076 9.6102 2.2769 13.2271
SNU-475 GDSC1 5.1295 6.9324 3.6126 3.2563
Hep 3B2.1-7 GDSC1 5.2083 7.2148 3.5305 3.6665
HuH-1 GDSC1 5.2414 6.9893 3.6542 2.7213
Huh-7 GDSC1 5.4376 7.4483 3.5615 2.9611
SNU-387 GDSC1 5.5548 7.4857 3.6109 2.4145
Hep-G2/C3A GDSC1 5.8995 7.2514 3.8722 0.5706
HLE GDSC1 6.9235 8.7235 3.7371 0.3739
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 172 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PaCa-3 GDSC1 1.2889 4.1297 1.0624 39.0474
NCI-H2087 GDSC1 3.0521 7.9828 1.3493 27.1239
CAL-12T GDSC1 3.1884 5.8156 2.5023 19.0165
HCC827 GDSC1 3.2426 6.0169 2.4653 19.0203
PC-14 GDSC1 3.5296 9.8216 0.8868 27.3267
EPLC-272H GDSC1 3.5905 5.982 2.8245 14.7383
HARA [Human squamous cell lung carcinoma] GDSC1 3.6573 6.7575 2.5139 16.7664
NCI-H358 GDSC1 3.7255 6.7971 2.5579 16.147
NCI-H1944 GDSC1 3.7551 6.9452 2.5124 16.3579
EMC-BAC-1 GDSC1 3.8137 5.5657 3.2385 10.5821
NCI-H647 GDSC1 3.8907 5.8942 3.1527 9.7351
SK-MES-1 GDSC1 3.9435 5.9784 3.1605 10.6261
SBC-3 GDSC1 3.9815 4.75 3.7847 5.6559
DMS 273 GDSC1 4.0241 4.9502 3.7347 5.2072
COR-L321 GDSC1 4.0492 5.9611 3.2653 9.3748
NCI-H810 GDSC1 4.0747 5.5374 3.4976 7.4556
NCI-H1437 GDSC1 4.0968 5.023 3.7698 5.2451
A-427 GDSC1 4.124 6.1793 3.2235 8.393
NCI-H3122 GDSC1 4.1439 5.2003 3.7268 5.3813
IST-SL2 GDSC1 4.1599 5.2025 3.7403 5.2097
HCC78 GDSC1 4.1728 5.4519 3.6284 5.3847
COR-L105 GDSC1 4.1769 6.0876 3.3155 8.477
NCI-H1155 GDSC1 4.1918 6.0722 3.3361 8.2585
COLO 668 GDSC1 4.1946 5.3704 3.6882 5.4794
NCI-H1648 GDSC1 4.229 6.0141 3.3972 7.6366
COR-L23 GDSC1 4.23 8.1036 2.354 15.6098
NCI-H64 GDSC1 4.3124 5.0243 3.9628 2.867
NCI-H847 GDSC1 4.3129 5.2299 3.8605 3.6721
NCI-H1048 GDSC1 4.3144 6.4711 3.2411 8.5478
NCI-H292 GDSC1 4.3318 5.6045 3.6889 4.957
LK-2 GDSC1 4.3703 7.7085 2.6688 12.7687
NCI-H1581 GDSC1 4.387 5.9667 3.5532 5.831
NCI-H226 GDSC1 4.3947 5.4716 3.8065 3.8089
NCI-H520 GDSC1 4.395 6.1586 3.4637 6.5079
NCI-H2122 GDSC1 4.3991 5.9256 3.5835 5.5503
NCI-H1355 GDSC1 4.4005 6.8406 3.1275 9.1301
Ms-1 GDSC1 4.4141 7.5926 2.7628 11.8999
ABC-1 GDSC1 4.4162 7.3545 2.8835 10.9682
NCI-H2085 GDSC1 4.4486 7.9361 2.6193 12.8578
BEN GDSC1 4.4855 6.057 3.5867 5.2324
NCI-H211 GDSC1 4.5217 6.5484 3.3705 6.8095
COR-L311 GDSC1 4.5242 6.1602 3.5654 5.2729
NCI-H1092 GDSC1 4.5268 6.555 3.3712 6.7871
NCI-H841 GDSC1 4.5384 5.7408 3.7838 3.5214
NCI-H1688 GDSC1 4.5401 7.9535 2.6846 10.789
NCI-H2030 GDSC1 4.5454 6.6923 3.3174 7.1464
LCLC-97TM1 GDSC1 4.5769 5.9921 3.6886 4.1438
NCI-H1755 GDSC1 4.5802 6.3331 3.5226 5.4282
NCI-H345 GDSC1 4.5853 5.9666 3.7075 3.9715
NCI-H1836 GDSC1 4.5942 6.0813 3.6575 4.3327
UMC-11 GDSC1 4.6072 6.399 3.5105 4.8523
NCI-H2170 GDSC1 4.6179 5.9456 3.7416 3.6097
RERF-LC-KJ GDSC1 4.6301 6.0665 3.6913 3.9629
NCI-H3255 GDSC1 4.6433 7.7674 2.8592 9.2776
NCI-H1770 GDSC1 4.6648 6.3358 3.5845 4.6855
SBC-5 GDSC1 4.6773 6.4427 3.5411 4.9842
LC-2/ad GDSC1 4.6891 6.7927 3.3775 6.2177
NCI-H661 GDSC1 4.7067 7.2479 3.1659 7.8051
SHP-77 GDSC1 4.7226 7.3078 3.1483 7.891
IST-SL1 GDSC1 4.7317 6.5438 3.5312 4.8993
Lu-65 GDSC1 4.737 7.5836 3.0227 8.8135
NCI-H2171 GDSC1 4.7623 6.3707 3.6372 3.9982
COR-L303 GDSC1 4.7851 13.6459 0.0401 26.2981
NCI-H1869 GDSC1 4.7895 7.3397 3.1827 7.4169
NCI-H2196 GDSC1 4.7922 6.9217 3.3901 5.8092
NCI-H1793 GDSC1 4.7959 6.4526 3.6211 4.0283
NCI-H2135 GDSC1 4.8046 7.7788 2.9774 8.9466
NCI-H720 GDSC1 4.8427 7.4419 3.1718 7.3392
HCC44 GDSC1 4.8622 7.0534 3.3761 5.7133
NCI-H510A GDSC1 4.8796 6.4252 3.6909 3.2827
NCI-H838 GDSC1 4.8904 6.1433 3.8301 1.9974
NCI-H460 GDSC1 4.8937 6.8975 3.4739 4.3534
NCI-H1876 GDSC1 4.9086 6.7905 3.5358 4.3694
NCI-H1694 GDSC1 4.9111 9.6616 2.1258 14.7967
NCI-H727 GDSC1 4.922 7.7406 3.0832 7.7794
COR-L88 GDSC1 4.9405 10.5331 1.7156 17.3626
NCI-H1975 GDSC1 4.944 10.1989 1.8844 16.284
NCI-H1573 GDSC1 4.9577 7.3739 3.2878 6.1153
NCI-H2731 GDSC1 4.965 7.0367 3.4559 4.8216
NCI-H82 GDSC1 4.9778 7.1588 3.4059 5.1644
EMC-BAC-2 GDSC1 4.99 7.5271 3.2362 6.4168
NCI-H1436 GDSC1 5.008 6.9047 3.5478 4.0211
NCI-H69 GDSC1 5.0303 8.8739 2.6059 11.0244
NCI-H1304 GDSC1 5.0743 8.4077 2.867 8.9607
NCI-H2029 GDSC1 5.0824 9.9656 2.1061 14.3734
NCI-H524 GDSC1 5.0845 10.8535 1.6678 17.1821
RERF-LC-MS GDSC1 5.0906 6.9245 3.5919 3.4964
SW1271 GDSC1 5.0984 7.3434 3.399 4.3714
NCI-H650 GDSC1 5.1205 7.4514 3.3622 5.115
NCI-H2444 GDSC1 5.1524 6.3158 3.9024 1.1177
NCI-H1563 GDSC1 5.1585 7.8035 3.2193 5.4319
EBC-1 GDSC1 5.1842 7.0854 3.5756 3.0322
NCI-H441 GDSC1 5.1953 8.5946 2.8625 8.6437
DMS 114 GDSC1 5.2046 7.5929 3.3506 4.9878
Calu-6 GDSC1 5.2171 6.8287 3.7126 2.3706
NCI-H526 GDSC1 5.2236 6.5017 3.86 1.3996
NCI-H23 GDSC1 5.2422 8.5341 2.9247 7.2039
NCI-H2228 GDSC1 5.2539 7.9258 3.225 5.1724
IA-LM GDSC1 5.2911 7.6929 3.3595 4.7108
NCI-H2803 GDSC1 5.3315 8.0489 3.2178 5.6481
NCI-H290 GDSC1 5.3615 9.2339 2.6691 9.5871
NCI-H1650 GDSC1 5.388 7.8792 3.3338 4.668
HOP-62 GDSC1 5.3976 12.7344 0.975 20.0798
NCI-H2141 GDSC1 5.4099 7.7222 3.4203 4
NCI-H1703 GDSC1 5.4138 10.4677 2.1047 12.0873
NCI-H446 GDSC1 5.4152 7.254 3.6356 2.5066
NCI-H596 GDSC1 5.4332 6.948 3.7785 1.5674
HCC33 GDSC1 5.5223 6.8959 3.8444 1.0688
NCI-H187 GDSC1 5.5309 6.5747 3.9744 0.4487
NCI-H522 GDSC1 5.5357 9.8688 2.4833 10.4204
NCI-H2023 GDSC1 5.5458 8.4019 3.1894 5.3374
NCI-H1915 GDSC1 5.5685 7.3476 3.6782 1.9666
ChaGo-K-1 GDSC1 5.5725 9.7799 2.5518 8.8458
NCI-H2172 GDSC1 5.6068 7.9063 3.4535 3.3593
DMS 79 GDSC1 5.6673 7.7515 3.556 2.5703
NCI-H1734 GDSC1 5.6761 9.2581 2.8706 7.3051
NCI-H748 GDSC1 5.686 7.7236 3.5783 2.3964
SK-LU-1 GDSC1 5.6899 9.9578 2.5465 9.5601
NCI-H196 GDSC1 5.7097 7.1113 3.8446 0.7651
Lu-99A GDSC1 5.728 9.663 2.7127 7.4441
CPC-N GDSC1 5.73 7.6466 3.6346 1.9791
DMS 53 GDSC1 5.7511 7.6986 3.6233 2.0141
NCI-H2342 GDSC1 5.7687 10.91 2.1418 12.0958
NCI-H2818 GDSC1 5.7782 7.665 3.6514 1.6129
NCI-H2369 GDSC1 5.7835 7.2452 3.8248 0.8764
Lu-135 GDSC1 5.7939 8.1467 3.4522 3.0159
Lu-165 GDSC1 5.8406 7.4708 3.7612 1.1264
NCI-H1568 GDSC1 5.8507 8.8355 3.1761 4.2517
LXF 289 GDSC1 5.8677 12.0857 1.6407 13.6609
SBC-1 GDSC1 5.9331 8.1823 3.5115 2.4085
NCI-H1435 GDSC1 6.0147 7.7399 3.7335 1.0752
NCI-H1993 GDSC1 6.0207 12.4045 1.5939 14.8196
Lu-134-A GDSC1 6.0243 8.3172 3.5012 2.3298
NCI-H2591 GDSC1 6.0298 9.507 2.9766 5.7448
NCI-H2009 GDSC1 6.0304 8.121 3.5865 1.8264
NCI-H2081 GDSC1 6.0459 16.0891 -0.194 23.4068
NCI-H2227 GDSC1 6.0786 7.8963 3.7004 1.1684
NCI-H2405 GDSC1 6.0896 10.7156 2.4509 9.1946
Calu-3 GDSC1 6.1146 7.7841 3.7602 0.8573
NCI-H322M GDSC1 6.1167 9.2891 3.1266 4.5543
HCC15 GDSC1 6.1652 10.8827 2.4211 9.2096
HOP-92 GDSC1 6.1788 8.3637 3.5587 1.5934
NCI-H1693 GDSC1 6.1964 9.2144 3.2048 3.893
NCI-H513 GDSC1 6.215 8.1049 3.6794 1.1288
NCI-H1781 GDSC1 6.2211 7.905 3.7593 0.7716
Lu-139 GDSC1 6.2594 15.2495 0.3766 20.4416
NCI-H2595 GDSC1 6.2974 8.5435 3.5419 1.7272
NCI-H1623 GDSC1 6.3479 8.8352 3.4465 2.1834
LC-1/sq GDSC1 6.3684 12.6974 1.6925 12.1471
A-549 GDSC1 6.4219 8.3666 3.6681 0.88
NCI-H2722 GDSC1 6.4265 8.2127 3.7285 0.7357
NCI-H2461 GDSC1 6.4906 8.2874 3.7268 0.6965
NCI-H2291 GDSC1 6.5332 8.2758 3.7482 0.5919
NCI-H2110 GDSC1 6.5332 9.9907 3.0491 3.8361
COR-L95 GDSC1 6.5374 8.1597 3.792 0.4482
LB647-SCLC GDSC1 6.5437 8.1248 3.8069 0.4012
NCI-H1792 GDSC1 6.5529 10.7545 2.7198 5.7209
NCI-H2373 GDSC1 6.6358 8.5377 3.6926 0.7221
NCI-H2795 GDSC1 6.6604 8.7166 3.6356 0.8243
LOU-NH91 GDSC1 6.6782 8.2494 3.8131 0.3253
EKVX GDSC1 6.7017 9.2767 3.4351 1.8045
NCI-H1838 GDSC1 6.9031 8.6056 3.7711 0.3402
SW1573 GDSC1 6.9118 13.9232 1.4702 13.2406
NCI-H209 GDSC1 6.935 8.5949 3.7865 0.2925
NCI-H1666 GDSC1 6.9658 8.8116 3.7218 0.4417
NCI-H1651 GDSC1 6.9794 8.638 3.7876 0.2751
NCI-H1299 GDSC1 7.0097 9.0894 3.6386 0.672
NCI-H2347 GDSC1 7.0361 9.0034 3.68 0.5273
NCI-H2869 GDSC1 7.3049 9.2362 3.698 0.3629
NCI-H2804 GDSC1 7.4103 9.5391 3.6306 0.4897
RERF-LC-Sq1 GDSC1 7.5041 17.167 0.3188 17.5749
LCLC-103H GDSC1 7.8011 16.2242 0.9602 13.9023
⏷ Show the Full List of 172 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1 4.4702 10.7094 1.2509 21.7304
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE-15 GDSC1 3.1753 9.9801 0.4884 30.6408
KYSE-450 GDSC1 3.8403 6.2119 2.9507 12.6822
TE-4 GDSC1 3.8542 5.3374 3.3862 9.2683
TE-6 GDSC1 4.2248 8.6628 2.07 17.6152
KYSE-140 GDSC1 4.244 10.1237 1.3559 21.9869
TE-9 GDSC1 4.4416 6.0255 3.5677 5.5288
TE-8 GDSC1 4.4649 6.9996 3.1003 9.1169
EC-GI-10 GDSC1 4.4944 5.7847 3.7288 4.0894
KYSE-180 GDSC1 4.5112 11.9147 0.6821 24.4759
TE-5 GDSC1 4.6024 6.2132 3.5986 4.7655
KYSE-270 GDSC1 4.6505 7.6235 2.9363 9.7588
TE-11 GDSC1 4.7484 6.6436 3.4945 5.1334
KYSE-410 GDSC1 4.7731 6.6312 3.5183 4.8783
KYSE-510 GDSC1 4.9055 8.5414 2.6766 10.8946
KYSE-150 GDSC1 4.9586 6.8906 3.5216 4.3436
TE-10 GDSC1 5.2226 6.7725 3.7409 2.1693
OE19 GDSC1 5.3111 6.5772 3.8729 1.1903
TE-1 GDSC1 5.7976 12.1679 1.5504 15.7041
COLO 680N GDSC1 6.002 7.3327 3.8835 0.4584
KYSE-70 GDSC1 6.1036 10.6828 2.4755 8.9951
T.T GDSC1 6.5535 8.3772 3.7189 0.6823
KYSE-520 GDSC1 6.7185 8.8893 3.5944 1.046
OE21 GDSC1 6.8372 8.4068 3.8163 0.2602
OE33 GDSC1 6.8759 9.1514 3.561 1.0546
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TOV-112D GDSC1 2.6384 4.8432 2.3198 20.6864
Caov-3 GDSC1 4.1575 4.8647 3.9037 3.9466
A2780 GDSC1 4.1691 7.2423 2.7325 13.0362
OVTOKO GDSC1 4.2399 8.9662 1.931 18.486
OC 314 GDSC1 4.2441 5.9238 3.4553 6.3547
OV-90 GDSC1 4.3201 6.191 3.3858 7.3883
JHOS-2 GDSC1 4.3529 5.7902 3.6134 5.4766
SK-OV-3 GDSC1 4.4563 6.3182 3.4334 6.535
RMG-I GDSC1 4.523 9.2149 2.041 16.7067
DOV13 GDSC1 4.5894 7.0243 3.1866 8.0228
EFO-27 GDSC1 4.6445 7.1622 3.1609 8.0433
OVK18 GDSC1 4.7432 7.1811 3.2265 7.2218
TOV-21G GDSC1 4.7864 6.2364 3.7187 3.315
OV56 GDSC1 4.9054 6.5182 3.6637 3.4194
FU-OV-1 GDSC1 5.0192 12.3721 0.8622 21.8631
OVCAR-8 GDSC1 5.0203 9.1908 2.4422 12.2388
IGROV-1 GDSC1 5.0787 8.284 2.9307 8.471
OAW28 GDSC1 5.1911 9.8987 2.2206 13.2552
ES-2 GDSC1 5.4078 9.3356 2.6522 9.5787
OVKATE GDSC1 5.5407 7.0835 3.7759 1.4247
OVCAR-5 GDSC1 5.6075 7.5698 3.6029 2.3743
OAW42 GDSC1 6.0191 10.8842 2.3246 10.2174
OVCAR-3 GDSC1 6.0438 8.1736 3.5713 1.8942
Caov-4 GDSC1 6.1134 9.2641 3.1359 4.499
OVCAR-4 GDSC1 6.5801 15.5669 0.4522 19.2458
TYK-nu GDSC1 6.9525 8.7662 3.7329 0.4176
EFO-21 GDSC1 7.1819 14.8604 1.2031 14.0529
Kuramochi GDSC1 7.3726 9.4152 3.6603 0.4284
OVISE GDSC1 8.0449 16.9413 0.7794 14.26
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PSN1 GDSC1 4.2238 5.1619 3.8176 4.348
KP-1N GDSC1 4.3127 6.9591 2.2759 5.6054
MZ-PC-1 GDSC1 4.3515 5.6238 3.6955 4.3138
KP-4 GDSC1 4.3851 5.6325 3.7186 4.0461
HuP-T4 GDSC1 4.498 7.2331 3.0104 8.6671
Capan-1 GDSC1 4.602 7.6225 2.8989 10.2075
HPAF-II GDSC1 4.6827 7.6543 2.9461 8.562
MIA PaCa-2 GDSC1 4.6863 10.5165 1.5228 19.4027
KP-2 GDSC1 4.6964 6.137 3.7044 3.2747
BxPC-3 GDSC1 4.8722 7.9061 2.9652 7.8942
PaTu 8902 GDSC1 4.8944 7.0084 3.4207 4.7131
QGP-1 GDSC1 5.1698 7.1161 3.5524 3.5975
SU.86.86 GDSC1 5.2389 7.3492 3.4872 3.4879
DAN-G GDSC1 5.2878 7.6073 3.3975 3.9652
Panc 10.05 GDSC1 5.4391 10.2416 2.2336 11.2145
PaTu 8988t GDSC1 5.5004 9.8858 2.4504 9.677
HuP-T3 GDSC1 5.5406 11.3475 1.7658 13.7938
CFPAC-1 GDSC1 5.6589 9.0872 2.9401 6.1334
SW1990 GDSC1 5.6814 8.1064 3.4066 3.1504
Panc 02.03 GDSC1 5.8653 9.1748 3.0293 5.1367
Panc 08.13 GDSC1 6.0627 8.2409 3.5526 1.7618
HPAC GDSC1 6.1546 11.6891 2.0311 10.6887
KP-3 GDSC1 6.2729 8.7594 3.4409 2.3193
Panc 03.27 GDSC1 6.302 8.025 3.7476 0.7549
Hs 766T GDSC1 6.468 8.0833 3.7928 0.431
Panc 04.03 GDSC1 6.8007 8.2258 3.8653 0.1566
SUIT-2 GDSC1 6.882 17.424 -0.2375 20.0612
AsPC-1 GDSC1 7.0606 11.1074 2.8481 4.1509
Capan-2 GDSC1 7.3071 9.01 3.7765 0.2037
PL4 GDSC1 7.319 15.8887 0.8052 14.5942
YAPC GDSC1 7.9194 15.8819 1.194 11.4987
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MSTO-211H GDSC1 5.3547 7.9227 3.2923 5.0469
NCI-H28 GDSC1 5.6265 8.4221 3.2302 4.8639
MPP 89 GDSC1 5.7149 7.4153 3.724 1.4799
IST-Mes1 GDSC1 5.7801 8.4918 3.2903 4.1212
NCI-H2052 GDSC1 6.4627 9.0855 3.3991 2.2937
NCI-H2452 GDSC1 7.2078 9.2599 3.6536 0.5194
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PC-3 GDSC1 4.4398 6.5751 3.292 7.7027
LNCaP clone FGC GDSC1 4.5823 10.2986 1.5477 19.6231
22Rv1 GDSC1 4.887 6.9011 3.4675 4.9455
VCaP GDSC1 4.899 6.4708 3.682 3.3001
DU145 GDSC1 5.0583 6.5806 3.7313 2.57
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1 4.4897 6.9279 3.156 8.5965
Cancer Drug Sensitivity Data Curated from 56 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-431 GDSC1 2.8463 6.1456 2.0072 24.1715
A-375 GDSC1 3.7848 4.3096 3.739 7.0138
Mel Ho GDSC1 3.8889 5.8445 3.1753 10.7416
SK-MEL-28 GDSC1 4.0909 6.8878 2.8417 12.5026
IGR-1 GDSC1 4.1032 6.9755 2.8088 12.7077
G-361 GDSC1 4.1633 5.01 3.8381 4.4317
CHL-1 GDSC1 4.169 5.8449 3.4296 7.6115
SK-MEL-30 GDSC1 4.2393 4.9616 3.9309 3.3971
G-mel GDSC1 4.3231 5.5313 3.7182 4.757
SK-MEL-2 GDSC1 4.3395 5.0969 3.949 2.878
WM1552C GDSC1 4.3467 6.0238 3.4915 6.4598
Mel JuSo GDSC1 4.3527 5.4748 3.7709 4.2353
COLO 800 GDSC1 4.3647 6.9378 3.0495 9.8664
RVH-421 GDSC1 4.4189 5.9287 3.5978 5.3692
WM35 GDSC1 4.4233 5.6416 3.7445 4.1996
MZ-MEL-7 GDSC1 4.455 6.4829 3.3502 7.1931
IGR-37 GDSC1 4.4844 5.699 3.7637 3.8485
IPC-298 GDSC1 4.5144 5.7178 3.7772 3.6478
CP66-MEL GDSC1 4.5242 5.7766 3.7555 3.7861
SK-MEL-5 GDSC1 4.5273 5.4957 3.8961 2.3946
MZ-MEL-2 GDSC1 4.5578 5.9633 3.6886 4.203
A-388 GDSC1 4.5854 6.3618 3.5123 5.4918
WM115 GDSC1 4.5919 6.2046 3.595 4.8261
A2058 GDSC1 4.6533 6.686 3.4034 5.4683
RPMI-7951 GDSC1 4.6694 6.0789 3.7135 3.6766
HMV-II GDSC1 4.7243 7.2333 3.1865 7.5901
WM793 GDSC1 4.7358 13.4364 0.1048 26.2047
COLO 792 GDSC1 4.736 5.885 3.8527 2.1791
SK-MEL-3 GDSC1 4.7853 5.961 3.8489 2.0956
MMAc-SF GDSC1 4.8275 6.8661 3.4426 5.3032
HT-144 GDSC1 4.8519 6.6091 3.5842 4.1558
WM278 GDSC1 4.8637 6.7255 3.5362 4.4877
WT2-iPS GDSC1 4.885 6.3402 3.7346 2.9454
COLO 783 GDSC1 4.8901 6.3026 3.7556 2.7795
GAK GDSC1 4.95 6.723 3.5958 3.8114
SK-MEL-1 GDSC1 4.9699 6.6782 3.6301 3.5071
IST-MEL1 GDSC1 4.9804 7.0076 3.4803 4.5966
UACC-257 GDSC1 5.0086 6.2386 3.8573 1.7993
COLO 679 GDSC1 5.0218 6.8154 3.599 3.6087
LB2518-MEL GDSC1 5.0512 8.2481 2.9285 8.5682
M14 GDSC1 5.1184 6.7997 3.6671 2.8928
LB373-MEL-D GDSC1 5.1757 7.6964 3.2822 5.5684
LOX-IMVI GDSC1 5.1977 7.5418 3.3703 4.8597
A101D GDSC1 5.3209 8.2451 3.1175 6.413
451Lu GDSC1 5.4385 7.1962 3.674 2.2125
CP50-MEL-B GDSC1 5.4508 7.3716 3.6034 2.6537
VMRC-MELG GDSC1 5.4708 7.2107 3.6853 2.0843
UACC-62 GDSC1 5.4986 6.6442 3.9339 0.6488
DJM-1 GDSC1 5.5128 7.3241 3.6586 2.1818
SH-4 GDSC1 5.6851 8.8837 3.0523 5.9895
MeWo GDSC1 6.0213 7.6502 3.7716 0.8918
Hs 938.T GDSC1 6.1746 7.9403 3.7258 0.8519
SK-MEL-24 GDSC1 6.3041 12.7901 1.6043 13.9957
Hs 940.T GDSC1 6.7702 8.4335 3.7825 0.3656
COLO 829 GDSC1 7.1459 9.0284 3.7124 0.3893
EquiPSC Line K2 GDSC1 4.5492 6.3755 3.4779 5.8774
⏷ Show the Full List of 56 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1 3.819 4.5907 3.6819 7.2269
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
G-401 GDSC1 3.8007 9.8734 1.1007 22.9918
EW-8 GDSC1 3.8661 4.9992 3.5555 7.9266
MES-SA GDSC1 3.8871 5.7812 3.2044 10.5237
Rh30 GDSC1 4.3634 6.7587 3.1379 9.1802
SK-LMS-1 GDSC1 4.4873 6.7463 3.2446 7.9115
TE 441.T GDSC1 4.5341 5.9457 3.6794 4.3492
SW872 GDSC1 4.9267 6.7434 3.5706 4.06
Hs 633.T GDSC1 4.9967 6.4719 3.7437 2.6181
VA-ES-BJ GDSC1 5.0167 6.8576 3.5758 3.7924
MFH-ino GDSC1 5.1877 7.5882 3.3417 5.0958
HT-1080 GDSC1 5.2116 6.8253 3.7109 2.3929
SK-UT-1 GDSC1 5.3032 7.1494 3.6181 2.844
STS-0421 GDSC1 5.5901 8.5485 3.1488 5.5241
Rh41 GDSC1 5.5979 7.4487 3.6502 2.0923
SW684 GDSC1 5.6535 6.8835 3.9086 0.62
A-204 GDSC1 5.6563 10.8427 2.0956 12.7146
KYM-1 GDSC1 5.6698 7.383 3.7151 1.5928
RKN GDSC1 5.8719 9.4923 2.886 6.7256
SW982 GDSC1 6.1741 7.535 3.8772 0.3798
RD GDSC1 6.4094 8.4381 3.635 1.1443
GCT GDSC1 6.4941 7.8073 3.8998 0.1947
Rh18 GDSC1 6.5728 7.9396 3.8825 0.2059
G-402 GDSC1 9.1339 20.9546 -0.4077 16.1035
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-1 GDSC1 3.1211 6.9093 1.9289 23.311
NCI-N87 GDSC1 3.2148 6.1098 2.3948 19.661
Hs 746.T GDSC1 3.3785 6.4928 2.3764 19.019
RF-48 GDSC1 3.6971 8.0217 1.9286 20.6935
ECC10 GDSC1 3.6992 8.0633 1.9099 20.8075
HGC-27 GDSC1 4.0437 5.1623 3.6521 6.3843
HSC-39 GDSC1 4.2149 5.3272 3.7276 5.09
RERF-GC-1B GDSC1 4.3212 6.0033 3.4807 6.637
23132/87 GDSC1 4.4119 5.7782 3.6673 4.8461
IM95 GDSC1 4.5683 8.8507 2.2595 13.5453
Fu97 GDSC1 4.69 8.1075 2.7264 10.0503
NUGC-4 GDSC1 5.024 8.0274 3.0167 7.9835
SCH GDSC1 5.0859 7.0025 3.5523 3.7962
SNU-5 GDSC1 5.1018 7.0062 3.5607 3.6965
MKN1 GDSC1 5.141 10.4984 1.8869 15.6264
MKN7 GDSC1 5.1932 7.1784 3.538 3.6473
MKN28 GDSC1 5.2151 8.8723 2.7413 9.4801
NUGC-3 GDSC1 5.6425 9.8283 2.5764 9.4771
SNU-16 GDSC1 5.8358 9.292 2.9567 6.3145
TGBC11TKB GDSC1 6.042 7.9192 3.6745 1.3385
OCUM-1 GDSC1 6.1176 8.0404 3.6609 1.3221
TMK-1 GDSC1 6.1401 8.0978 3.6483 1.3603
GCIY GDSC1 6.1565 8.4281 3.5212 2.0231
MKN45 GDSC1 6.2082 12.885 1.4922 14.9004
AGS GDSC1 7.0803 13.6775 1.6945 11.5742
SNG-M GDSC1 4.1026 5.0183 3.7775 5.1596
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IHH-4 GDSC1 4.1136 5.625 3.4896 6.5669
B-CPAP GDSC1 4.6491 6.1796 3.6496 4.2283
HTC-C3 GDSC1 4.7679 6.3504 3.651 3.8776
CAL-62 GDSC1 4.7807 6.497 3.589 4.3152
BHT-101 GDSC1 4.8539 6.5443 3.6167 3.9048
KMH-2 GDSC1 4.9427 7.5541 3.1895 6.1691
TT GDSC1 5.1171 7.4594 3.3562 5.1689
FTC-133 GDSC1 5.2347 7.2178 3.5455 3.4992
8505C GDSC1 5.4339 8.9899 2.837 8.1716
CGTH-W-1 GDSC1 5.6266 7.4058 3.6836 1.8426
ASH-3 GDSC1 6.3109 8.0042 3.7592 0.6271
ML-1 [Human leukemia] GDSC1 6.3882 7.8461 3.8474 0.3216
WRO GDSC1 6.3883 7.8493 3.8463 0.3635
8305C GDSC1 6.5288 8.3393 3.7229 0.6842
K5 GDSC1 6.9367 8.4484 3.8374 0.1902
TT2609-C02 GDSC1 6.9919 15.519 0.7619 16.745
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H3118 GDSC1 2.9214 8.4702 0.99 27.0288
PCI-06A GDSC1 4.0849 8.012 2.2758 16.7281
SCC-25 GDSC1 4.115 7.9796 2.318 16.31
SCC-9 GDSC1 4.2154 12.6572 0.0652 28.168
SAS GDSC1 4.4173 7.4701 2.8266 11.4013
HSC-3 GDSC1 4.4411 7.9121 2.6251 12.8416
LB771-HNC GDSC1 4.4536 6.3746 3.4032 6.7818
CAL-33 GDSC1 4.5308 7.9678 2.67 12.1883
PCI-04B GDSC1 4.7445 8.0565 2.7941 10.5331
BB30-HNC GDSC1 4.8749 8.0809 2.881 9.4601
HO-1-u-1 GDSC1 4.9554 7.007 3.4636 4.2735
PCI-15A GDSC1 5.0822 11.2491 1.4698 18.3726
SAT [Human HNSCC] GDSC1 5.1605 7.3049 3.458 4.3061
CAL-27 GDSC1 5.1788 10.5802 1.8751 15.5822
FaDu GDSC1 5.2154 9.8793 2.2481 12.9914
HO-1-N-1 GDSC1 5.2589 8.0276 3.1798 6.1133
HSC-4 GDSC1 5.3657 6.739 3.8325 1.2023
BICR 22 GDSC1 5.4342 6.9861 3.7628 1.6612
PE/CA-PJ15 GDSC1 5.5021 8.9444 2.9048 6.7146
JHU-011 GDSC1 5.5442 12.0635 1.4165 17.2286
Detroit 562 GDSC1 5.5444 9.2581 2.7833 8.2664
SCC-15 GDSC1 5.6096 9.3003 2.8068 7.107
OSC-19 GDSC1 5.6242 12.8017 1.1124 18.6682
BICR 78 GDSC1 5.6493 9.7725 2.6078 9.2379
KON GDSC1 5.8079 9.261 2.9537 6.4002
PCI-30 GDSC1 5.824 7.4399 3.766 1.0004
BICR 31 GDSC1 5.8465 7.6964 3.6722 1.594
PCI-38 GDSC1 5.8524 11.2534 2.0339 12.568
Ca9-22 GDSC1 5.9478 9.6782 2.8471 6.8203
HSC-2 GDSC1 6.006 9.853 2.8022 6.9971
OSC-20 GDSC1 6.1573 11.5066 2.12 10.1518
DOK GDSC1 6.2104 8.2508 3.6194 1.4271
BHY GDSC1 6.4779 13.6446 1.312 15.2004
SKN-3 GDSC1 6.5491 8.7849 3.5611 1.3505
UPCI-SCC-090 GDSC1 6.5999 8.7061 3.6139 1.0642
SCC-4 GDSC1 6.8257 8.6034 3.743 0.4479
BICR 10 GDSC1 6.8456 8.3945 3.8235 0.2423
BB49-HNC GDSC1 7.0877 9.1958 3.6304 0.6532
JHU-022 GDSC1 7.5218 9.5832 3.6562 0.3809
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BFTC-905 GDSC1 4.0502 5.5082 3.4895 7.6204
RT-4 GDSC1 4.1537 6.3038 3.1875 8.5428
HT-1376 GDSC1 4.3735 6.6268 3.2122 7.6428
UM-UC-3 GDSC1 4.4638 5.5764 3.8087 3.5624
5637 GDSC1 4.5085 6.0366 3.6147 4.9375
639V GDSC1 4.5389 5.5364 3.8846 2.738
SW1710 GDSC1 4.8706 7.4125 3.2067 6.9879
KU-19-19 GDSC1 5.2508 7.3086 3.5134 3.6923
HT-1197 GDSC1 5.3152 7.216 3.595 2.9788
T24 GDSC1 5.3518 8.8398 2.853 8.2765
CAL-29 GDSC1 5.7167 7.2924 3.7753 1.1979
TCCSUP GDSC1 5.7262 7.2019 3.8161 0.9784
J82 GDSC1 6.1645 9.2387 3.1762 4.1367
SW780 GDSC1 6.3552 7.9621 3.7927 0.5501
RT-112 GDSC1 6.6553 7.9741 3.8998 0.1522
647V GDSC1 7.8626 16.8706 0.696 15.0472
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BPH-1 GDSC1 2.4121 6.7144 1.3118 30.6359
PA-1 GDSC1 2.9116 4.8885 2.5979 19.7527
ME-180 GDSC1 3.7951 9.6015 1.2312 24.4556
Ca Ski GDSC1 4.239 12.6623 0.0825 28.0159
JAR GDSC1 4.295 7.3628 2.7789 12.2094
HeLa GDSC1 4.3345 5.3438 3.8214 3.9022
NEC8 GDSC1 4.3552 5.5224 3.7492 4.3973
SW954 GDSC1 4.5498 6.1131 3.6084 4.8539
C-33 A GDSC1 4.5669 6.6929 3.3339 6.9467
OV17R GDSC1 4.6847 7.7171 2.9164 9.7984
DSH1 GDSC1 4.7287 8.4085 2.6069 11.9846
HEY GDSC1 4.7785 6.6789 3.4989 5.0119
ACC-OV7 GDSC1 4.843 6.6178 3.5738 4.2585
PEO1 GDSC1 4.8457 6.9078 3.4352 5.3073
MS751 GDSC1 4.8786 7.4999 3.1696 7.2485
OVMIU GDSC1 4.8848 9.6461 2.1132 14.9689
DoTc2 4510 GDSC1 4.913 7.4858 3.2015 6.9027
OMC-1 [Human cervical carcinoma] GDSC1 4.916 8.1078 2.8984 9.2018
NT2-D1 GDSC1 4.9645 6.7761 3.5801 3.8913
NCC-IT GDSC1 5.1127 7.0446 3.5497 3.7509
CAL-39 GDSC1 5.1213 7.2442 3.4612 4.3789
C-4-I GDSC1 5.1263 6.9504 3.6022 3.3386
HEC-1 GDSC1 5.2023 7.8214 3.2403 5.8108
JEG-3 GDSC1 5.209 7.4189 3.4356 4.3531
OVCA420 GDSC1 5.3603 7.7805 3.3624 4.5258
SKG-IIIa GDSC1 5.4752 9.2318 2.749 8.6974
SiSo GDSC1 5.6391 9.7973 2.589 9.3977
SiHa GDSC1 5.6493 7.0856 3.8273 1.0078
JHOS-3 GDSC1 5.7499 9.3038 2.8968 6.9388
HT-3 GDSC1 5.8988 8.1964 3.4873 2.6125
OVCA433 GDSC1 5.9955 11.1077 2.2021 11.0891
SKN GDSC1 6.1086 12.806 1.4609 14.0564
LB831-BLC GDSC1 6.1451 8.2001 3.6093 1.5557
UWB1.289 GDSC1 6.562 11.9274 2.1845 9.804
SW756 GDSC1 6.6867 8.306 3.7963 0.365
SW962 GDSC1 6.981 8.6938 3.7688 0.3164
KGN GDSC1 7.0114 8.9276 3.6977 0.488
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug

References

1 ClinicalTrials.gov (NCT00760864) Safety and Efficacy of TAK-715 in Subjects With Rheumatoid Arthritis. U.S. National Institutes of Health.
2 Inhibition of Wnt/beta-catenin signaling by p38 MAP kinase inhibitors is explained by cross-reactivity with casein kinase Idelta/ . Chem Biol. 2011 Apr 22;18(4):485-94.
3 Oleanolic acid induces HCT116 colon cancer cell death through the p38/FOXO3a/Sirt6 pathway. Chem Biol Interact. 2022 Aug 25;363:110010. doi: 10.1016/j.cbi.2022.110010. Epub 2022 Jun 9.