Details of the Drug Transporter (DTP)

General Information of Drug Transporter (DTP) (ID: DTB49TS)

DTP Name High affinity cationic amino acid transporter 1 (SLC7A1)
Gene Name SLC7A1
UniProt ID
P30825 (CTR1_HUMAN)
VARIDT ID
DTD0462
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Synonyms
ATRC1; CAT-1; CAT1; ERR; Ecotropic retroviral leukemia receptor homolog; Ecotropic retrovirus receptor homolog; HCAT1; REC1L; SLC7A1; Solute carrier family 7 member 1; System Y+ basic amino acid transporter
DTP Family Amino Acid-Polyamine-Organocation (APC) Family
Cationic Amino Acid Transporter (CAT) Family
Tissue Specificity Ubiquitous.
Function This transporter is high-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues.
Endogenous Substrate(s) Arginine; Lysine; Ornithine
TCDB ID
2.A.3.3.9
Gene ID
6541
KEGG Pathway
MicroRNAs in cancer (hsa05206 )
Reactome Pathway
Amino acid transport across the plasma membrane (R-HSA-352230 )

Molecular Expression Atlas (MEA) of This DTP

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DTP
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Acute myelocytic leukaemia 2B33.1 Bone marrow 1.06E-01 7.38E-02 3.03E-01
Adrenocortical carcinoma 2D11.Z Kidney 4.35E-01 2.88E-01 5.47E-01
Alopecia ED70 Skin from scalp 2.99E-03 -1.49E-01 -5.17E-01
Alzheimer's disease 8A20 Entorhinal cortex 2.70E-01 -3.27E-02 -1.62E-01
Ankylosing spondylitis FA92.0 Pheripheral blood 7.84E-01 -1.05E-01 -2.76E-01
Aortic stenosis BB70 Calcified aortic valve 4.92E-01 8.55E-02 2.82E-01
Apnea 7A40 Hyperplastic tonsil 8.78E-02 -2.45E-01 -1.00E+00
Arthropathy FA00-FA5Z Peripheral blood 1.78E-01 6.57E-02 3.53E-01
Asthma CA23 Nasal and bronchial airway 5.33E-04 -1.07E-01 -1.24E-01
Atopic dermatitis EA80 Skin 8.04E-06 2.70E-01 1.32E+00
Autism 6A02 Whole blood 3.31E-01 3.66E-02 1.67E-01
Autoimmune uveitis 9A96 Peripheral monocyte 8.99E-01 -4.72E-02 -1.01E-01
Autosomal dominant monocytopenia 4B04 Whole blood 9.78E-01 6.53E-02 1.42E-01
Bacterial infection of gingival 1C1H Gingival tissue 1.40E-02 -1.39E-01 -3.47E-01
Batten disease 5C56.1 Whole blood 3.38E-01 5.79E-02 3.81E-01
Behcet's disease 4A62 Peripheral blood 3.05E-01 -4.31E-02 -2.44E-01
Bipolar disorder 6A60-6A6Z Prefrontal cortex 9.59E-01 5.51E-02 2.69E-01
Bladder cancer 2C94 Bladder tissue 4.33E-02 3.42E-01 7.90E-01
Breast cancer 2C60-2C6Z Breast tissue 1.52E-01 4.42E-02 8.85E-02
Cardioembolic stroke 8B11.20 Whole blood 7.11E-04 8.33E-02 5.08E-01
Cervical cancer 2C77 Cervical tissue 5.12E-01 -3.24E-03 -1.32E-02
Childhood onset rheumatic disease FA20.Z Peripheral blood 4.25E-02 1.67E-01 5.68E-01
Chronic hepatitis C 1E51.1 Whole blood 5.01E-01 1.34E-01 6.10E-01
Chronic obstructive pulmonary disease CA22 Lung tissue 7.15E-01 5.73E-02 1.89E-01
Chronic obstructive pulmonary disease CA22 Small airway epithelium 6.04E-01 -3.27E-02 -9.50E-02
Chronic rhinosinusitis CA0A Sinus mucosa tissue 8.09E-01 -1.67E-01 -5.08E-01
Colon cancer 2B90 Colon tissue 6.02E-10 1.43E-01 3.72E-01
Coronary artery disease BA80-BA8Z Peripheral blood 7.50E-01 -1.38E-02 -4.36E-02
Diffuse large B-cell lymphoma 2A81 Tonsil tissue 4.19E-01 -1.23E-02 -4.94E-02
Endometriosis GA10 Endometrium tissue 7.63E-04 -1.84E-01 -3.00E-01
Familial hypercholesterolemia 5C80.00 Peripheral blood 9.92E-01 -4.83E-02 -1.88E-01
Familial hypercholesterolemia 5C80.00 Whole blood 4.88E-01 7.31E-02 3.63E-01
Gastric cancer 2B72 Gastric tissue 1.79E-01 3.74E-01 1.29E+00
Glioblastopma 2A00.00 Nervous tissue 9.05E-57 -4.01E-01 -1.10E+00
Glioma 2A00.0Y-2A00.0Z White matter tissue 2.59E-02 1.49E-01 4.57E-01
Head and neck cancer 2D42 Head and neck tissue 3.28E-08 4.26E-01 6.23E-01
HIV-associated neurocognitive impairment 8A2Y-8A2Z White matter tissue 4.98E-02 -5.01E-02 -2.68E-01
Huntington's disease 8A01.10 Whole blood 4.95E-01 3.71E-03 1.74E-02
Idiopathic pulmonary fibrosis CB03.4 Lung tissue 5.46E-02 -4.15E-01 -1.35E+00
Immunodeficiency 4A00-4A20 Peripheral blood 9.95E-01 4.18E-02 5.29E-01
Influenza 1.00E+30 Whole blood 5.91E-02 -5.59E-01 -2.34E+00
Interstitial cystitis GC00.3 Bladder tissue 2.37E-01 2.04E-01 1.13E+00
Intracranial aneurysm 8B01.0 Intracranial artery 2.06E-01 -1.81E-01 -4.85E-01
Irritable bowel syndrome DD91.0 Rectal colon tissue 3.52E-02 8.72E-02 2.63E-01
Ischemic stroke 8B11 Peripheral blood 9.14E-01 3.58E-02 1.23E-01
Juvenile idiopathic arthritis FA24 Peripheral blood 1.16E-01 3.68E-02 1.26E-01
Lateral sclerosis 8B60.4 Cervical spinal cord 8.63E-02 -4.16E-01 -1.35E+00
Lateral sclerosis 8B60.4 Skin 4.54E-01 -1.09E-01 -3.38E-01
Liver cancer 2C12.0 Liver tissue 1.33E-01 6.29E-02 1.90E-01
Liver failure DB99.7-DB99.8 Liver tissue 3.26E-01 -1.01E-01 -3.13E-01
Lung cancer 2C25 Lung tissue 5.54E-14 2.58E-01 8.96E-01
Lupus erythematosus 4A40 Whole blood 1.52E-06 -5.71E-01 -1.07E+00
Major depressive disorder 6A70-6A7Z Whole blood 1.21E-01 1.82E-02 9.51E-02
Major depressive disorder 6A70-6A7Z Hippocampus 8.87E-01 1.30E-02 6.40E-02
Melanoma 2C30 Skin 1.81E-03 4.99E-01 7.86E-01
Multiple myeloma 2A83.1 Bone marrow 4.12E-02 2.60E-01 1.09E+00
Multiple myeloma 2A83.1 Peripheral blood 4.34E-01 -5.28E-02 -1.22E-01
Multiple sclerosis 8A40 Plasmacytoid dendritic cells 3.73E-01 3.26E-01 7.17E-01
Myelodysplastic syndrome 2A36-2A3Z Bone marrow 9.03E-01 -1.99E-03 -1.11E-02
Myelofibrosis 2A20.2 Whole blood 2.38E-02 -9.17E-02 -6.98E-01
Myocardial infarction BA41-BA50 Peripheral blood 8.61E-01 6.44E-02 1.27E-01
Myopathy 8C70.6 Muscle tissue 2.46E-01 4.63E-01 1.06E+00
Neonatal sepsis KA60 Whole blood 6.75E-01 -3.65E-02 -1.37E-01
Neuroectodermal tumour 2A00.11 Brain stem tissue 2.46E-01 -3.16E-02 -7.12E-02
Non-alcoholic fatty liver disease DB92 Liver tissue 5.05E-01 8.10E-02 3.87E-01
Obesity related type 2 diabetes 5A11 Omental adipose tissue 8.51E-01 -2.60E-03 -7.76E-03
Olive pollen allergy CA08.00 Peripheral blood 4.30E-01 1.85E-01 5.72E-01
Oral cancer 2B6E Oral tissue 2.81E-02 -7.65E-02 -1.51E-01
Osteoarthritis FA00-FA0Z Synovial tissue 1.90E-01 -6.72E-02 -2.42E-01
Osteoporosis FB83.1 Bone marrow 1.90E-01 8.15E-02 4.26E-01
Ovarian cancer 2C73 Ovarian tissue 3.21E-01 1.57E-01 4.43E-01
Pancreatic cancer 2C10 Pancreas 6.27E-03 -3.90E-01 -8.12E-01
Parkinson's disease 8A00.0 Substantia nigra tissue 3.19E-01 -5.87E-02 -1.62E-01
Pediatric respiratory syncytial virus infection CA40.11 Peripheral blood 9.43E-01 1.10E-02 5.26E-02
Pituitary cancer 2D12 Pituitary tissue 6.82E-01 -1.96E-01 -6.73E-01
Pituitary gonadotrope tumour 2D12 Pituitary tissue 2.23E-02 -4.59E-01 -1.48E+00
Polycystic ovary syndrome 5A80.1 Vastus lateralis muscle 2.62E-01 9.75E-02 4.99E-01
Polycythemia vera 2A20.4 Whole blood 8.07E-06 -1.55E-01 -1.04E+00
Pompe disease 5C51.3 Biceps muscle 4.28E-01 -4.97E-02 -1.65E-01
Preterm birth KA21.4Z Myometrium 1.07E-01 -3.32E-02 -2.75E-01
Prostate cancer 2C82 Prostate 2.99E-08 6.82E-01 1.26E+00
Psoriasis EA90 Skin 5.97E-22 7.02E-01 1.49E+00
Rectal cancer 2B92 Rectal colon tissue 5.65E-04 4.65E-01 2.32E+00
Renal cancer 2C90-2C91 Kidney 9.05E-01 6.83E-03 2.64E-02
Retinoblastoma 2D02.2 Uvea 4.44E-02 2.73E-01 1.33E+00
Rheumatoid arthritis FA20 Synovial tissue 7.05E-01 5.47E-02 1.20E-01
Rhinovirus infection CA42.1 Nasal epithelium tissue 5.23E-01 -5.75E-03 -3.16E-02
Schizophrenia 6A20 Prefrontal cortex 8.87E-01 -5.04E-03 -1.81E-02
Schizophrenia 6A20 Superior temporal cortex 3.37E-01 3.07E-03 1.59E-02
Scleroderma 4A42.Z Whole blood 3.53E-02 2.72E-01 1.08E+00
Seizure 8A60-8A6Z Whole blood 7.13E-02 -2.37E-01 -8.46E-01
Sensitive skin EK0Z Skin 3.87E-01 6.47E-02 2.94E-01
Sepsis with septic shock 1G41 Whole blood 2.70E-05 9.07E-02 3.39E-01
Shwachman-Diamond syndrome 3A70.0 Bone marrow 5.19E-01 1.13E-01 7.80E-01
Sickle cell disease 3A51.0-3A51.3 Peripheral blood 5.93E-01 9.49E-02 3.21E-01
Simpson golabi behmel syndrome LD2C Adipose tissue 8.35E-01 9.29E-03 2.21E-02
Sjogren's syndrome 4A43.2 Salivary gland tissue 7.92E-05 -6.17E-01 -7.72E+00
Skin cancer 2C30-2C3Z Skin 8.26E-02 -1.35E-01 -2.36E-01
Thrombocythemia 3B63 Whole blood 1.62E-06 -1.70E-01 -1.46E+00
Thrombocytopenia 3B64 Whole blood 8.35E-01 -3.63E-03 -5.05E-03
Thyroid cancer 2D10 Thyroid 7.19E-01 -3.00E-02 -1.04E-01
Tibial muscular dystrophy 8C75 Muscle tissue 2.21E-01 7.97E-02 3.35E-01
Tuberous sclerosis complex LD2D.2 Perituberal tissue 5.82E-01 -1.02E-03 -5.12E-03
Type 2 diabetes 5A11 Liver tissue 3.27E-01 1.71E-01 9.47E-01
Ureter cancer 2C92 Urothelium 5.80E-01 6.46E-02 2.16E-01
Uterine cancer 2C78 Endometrium tissue 2.58E-04 -1.30E-01 -2.57E-01
Vitiligo ED63.0 Skin 2.90E-01 5.06E-01 1.04E+00
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⏷ Show the Full List of Expression Under 107 Diseases

The Drug Therapeutic Target (DTT) Role of This DTP

DTP DTT Name High-affinity cationic amino acid transporter-1 (SLC7A1) DTT Info
DTP DTT Type Literature-reported