Details of the Drug Transporter (DTP)

General Information of Drug Transporter (DTP) (ID: DTGBPR5)

DTP Name Equilibrative nucleobase transporter 1 (SLC43A3)
Gene Name SLC43A3
UniProt ID
Q8NBI5 (S43A3_HUMAN)
VARIDT ID
DTD0362
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Synonyms EEG1; ENBT1; FOAP-13; PRO1659; PSEC0252; Protein FOAP-13; SEEEG-1; SLC43A3; Solute carrier family 43 member 3
DTP Family Major Facilitator Superfamily (MFS)
L-Amino Acid Transporter-3 (LAT3) Family
Tissue Specificity Highly expressed in the liver, where it was localized to the sinusoidal membrane of hepatocytes, and the lung.
Sequence
MAGQGLPLHVATLLTGLLECLGFAGVLFGWPSLVFVFKNEDYFKDLCGPDAGPIGNATGQ
ADCKAQDERFSLIFTLGSFMNNFMTFPTGYIFDRFKTTVARLIAIFFYTTATLIIAFTSA
GSAVLLFLAMPMLTIGGILFLITNLQIGNLFGQHRSTIITLYNGAFDSSSAVFLIIKLLY
EKGISLRASFIFISVCSTWHVARTFLLMPRGHIPYPLPPNYSYGLCPGNGTTKEEKETAE
HENRELQSKEFLSAKEETPGAGQKQELRSFWSYAFSRRFAWHLVWLSVIQLWHYLFIGTL
NSLLTNMAGGDMARVSTYTNAFAFTQFGVLCAPWNGLLMDRLKQKYQKEARKTGSSTLAV
ALCSTVPSLALTSLLCLGFALCASVPILPLQYLTFILQVISRSFLYGSNAAFLTLAFPSE
HFGKLFGLVMALSAVVSLLQFPIFTLIKGSLQNDPFYVNVMFMLAILLTFFHPFLVYREC
RTWKESPSAIA
Function An orphan transporter belonging to an amino acid transporter family, as a purine-selective nucleobase transporter.
Endogenous Substrate(s) Purine nucleobases; Adenine; Guanine; Hypoxanthine
TCDB ID
2.A.1.44.3
Gene ID
29015

Molecular Interaction Atlas (MIA) of This DTP

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTP
1 Approved Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mercaptopurine DMTM2IK Acute lymphoblastic leukaemia 2A85 Approved [1]
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Molecular Expression Atlas (MEA) of This DTP

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DTP
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Acute myelocytic leukaemia 2B33.1 Bone marrow 1.57E-04 -2.87E-01 -4.50E-01
Adrenocortical carcinoma 2D11.Z Kidney 7.63E-01 -5.06E-04 -1.43E-03
Alopecia ED70 Skin from scalp 6.96E-01 1.25E-02 3.65E-02
Alzheimer's disease 8A20 Entorhinal cortex 6.28E-08 2.39E-01 8.70E-01
Ankylosing spondylitis FA92.0 Pheripheral blood 2.06E-01 6.63E-02 2.44E-01
Aortic stenosis BB70 Calcified aortic valve 1.85E-01 2.35E-01 6.89E-01
Apnea 7A40 Hyperplastic tonsil 9.89E-01 2.58E-02 8.75E-02
Arthropathy FA00-FA5Z Peripheral blood 6.72E-01 3.34E-02 1.82E-01
Asthma CA23 Nasal and bronchial airway 4.64E-01 -1.68E-02 -3.49E-02
Atopic dermatitis EA80 Skin 1.89E-01 -1.48E-01 -6.30E-01
Autism 6A02 Whole blood 9.03E-01 -3.49E-02 -1.07E-01
Autoimmune uveitis 9A96 Peripheral monocyte 5.27E-01 2.80E-01 1.01E+00
Autosomal dominant monocytopenia 4B04 Whole blood 1.38E-02 1.61E+00 1.75E+00
Bacterial infection of gingival 1C1H Gingival tissue 9.82E-09 3.41E-01 9.53E-01
Batten disease 5C56.1 Whole blood 5.36E-01 -2.46E-02 -1.48E-01
Behcet's disease 4A62 Peripheral blood 2.41E-01 1.01E-01 3.28E-01
Bipolar disorder 6A60-6A6Z Prefrontal cortex 9.04E-01 -5.40E-02 -2.46E-01
Bladder cancer 2C94 Bladder tissue 1.20E-02 -1.22E+00 -2.08E+00
Breast cancer 2C60-2C6Z Breast tissue 2.40E-12 -4.10E-01 -7.31E-01
Cardioembolic stroke 8B11.20 Whole blood 1.63E-01 6.61E-02 2.34E-01
Cervical cancer 2C77 Cervical tissue 3.03E-05 4.27E-01 1.45E+00
Childhood onset rheumatic disease FA20.Z Peripheral blood 2.46E-01 1.80E-02 2.44E-02
Chronic hepatitis C 1E51.1 Whole blood 4.82E-01 1.62E-01 3.77E-01
Chronic obstructive pulmonary disease CA22 Lung tissue 3.42E-01 4.35E-02 1.05E-01
Chronic obstructive pulmonary disease CA22 Small airway epithelium 3.50E-01 -3.49E-02 -9.28E-02
Chronic rhinosinusitis CA0A Sinus mucosa tissue 1.66E-02 3.26E-01 1.41E+00
Colon cancer 2B90 Colon tissue 1.47E-10 2.08E-01 5.30E-01
Coronary artery disease BA80-BA8Z Peripheral blood 3.02E-01 1.49E-01 6.43E-01
Diffuse large B-cell lymphoma 2A81 Tonsil tissue 7.22E-01 1.77E-02 2.73E-02
Endometriosis GA10 Endometrium tissue 2.06E-01 3.29E-01 6.85E-01
Familial hypercholesterolemia 5C80.00 Peripheral blood 2.15E-02 -2.05E-01 -6.28E-01
Familial hypercholesterolemia 5C80.00 Whole blood 2.21E-11 1.24E+00 1.67E+00
Gastric cancer 2B72 Gastric tissue 1.50E-04 6.19E-01 8.75E+00
Glioblastopma 2A00.00 Nervous tissue 6.84E-152 9.07E-01 2.14E+00
Glioma 2A00.0Y-2A00.0Z White matter tissue 5.89E-02 1.27E+00 9.90E-01
Head and neck cancer 2D42 Head and neck tissue 1.17E-21 6.72E-01 1.46E+00
HIV-associated neurocognitive impairment 8A2Y-8A2Z White matter tissue 8.59E-01 1.04E-01 3.23E-01
Huntington's disease 8A01.10 Whole blood 2.95E-01 7.88E-02 1.82E-01
Idiopathic pulmonary fibrosis CB03.4 Lung tissue 1.21E-01 3.21E-01 9.67E-01
Immunodeficiency 4A00-4A20 Peripheral blood 4.95E-02 1.81E-01 2.46E+00
Influenza 1.00E+30 Whole blood 3.56E-02 -3.29E-01 -1.26E+00
Interstitial cystitis GC00.3 Bladder tissue 1.92E-01 7.62E-02 1.14E-01
Intracranial aneurysm 8B01.0 Intracranial artery 6.06E-01 3.06E-01 5.62E-01
Irritable bowel syndrome DD91.0 Rectal colon tissue 3.87E-01 -1.62E-01 -4.56E-01
Ischemic stroke 8B11 Peripheral blood 3.37E-01 1.68E-02 6.45E-02
Juvenile idiopathic arthritis FA24 Peripheral blood 3.72E-06 -4.02E-01 -9.20E-01
Lateral sclerosis 8B60.4 Cervical spinal cord 5.11E-01 1.61E-01 7.07E-01
Lateral sclerosis 8B60.4 Skin 4.97E-02 3.56E-01 1.56E+00
Liver cancer 2C12.0 Liver tissue 1.55E-11 -8.39E-01 -1.48E+00
Liver failure DB99.7-DB99.8 Liver tissue 3.80E-04 -8.77E-01 -2.04E+00
Lung cancer 2C25 Lung tissue 4.90E-32 -5.75E-01 -1.42E+00
Lupus erythematosus 4A40 Whole blood 3.86E-02 1.53E-01 2.69E-01
Major depressive disorder 6A70-6A7Z Whole blood 2.45E-01 6.97E-02 2.60E-01
Major depressive disorder 6A70-6A7Z Hippocampus 3.24E-01 -8.68E-02 -4.17E-01
Melanoma 2C30 Skin 8.47E-07 1.34E+00 1.53E+00
Multiple myeloma 2A83.1 Bone marrow 1.15E-03 -4.87E-01 -2.15E+00
Multiple myeloma 2A83.1 Peripheral blood 7.00E-01 -5.36E-01 -5.07E-01
Multiple sclerosis 8A40 Plasmacytoid dendritic cells 4.32E-01 -2.40E-01 -5.77E-01
Myelodysplastic syndrome 2A36-2A3Z Bone marrow 2.06E-01 -3.04E-03 -8.70E-03
Myelofibrosis 2A20.2 Whole blood 8.54E-02 -8.24E-02 -4.09E-01
Myocardial infarction BA41-BA50 Peripheral blood 3.89E-01 2.16E-01 2.76E-01
Myopathy 8C70.6 Muscle tissue 2.56E-02 6.53E-01 1.35E+00
Neonatal sepsis KA60 Whole blood 1.45E-22 5.74E-01 1.75E+00
Neuroectodermal tumour 2A00.11 Brain stem tissue 8.65E-01 2.10E-02 9.06E-02
Non-alcoholic fatty liver disease DB92 Liver tissue 5.38E-01 -4.99E-03 -1.89E-02
Obesity related type 2 diabetes 5A11 Omental adipose tissue 9.48E-01 1.41E-01 4.38E-01
Olive pollen allergy CA08.00 Peripheral blood 4.77E-01 8.07E-02 2.53E-01
Oral cancer 2B6E Oral tissue 1.12E-07 5.41E-01 1.46E+00
Osteoarthritis FA00-FA0Z Synovial tissue 8.99E-01 3.37E-01 3.52E-01
Osteoporosis FB83.1 Bone marrow 3.24E-01 -1.99E-01 -2.20E-01
Ovarian cancer 2C73 Ovarian tissue 2.97E-03 5.63E-01 1.28E+00
Pancreatic cancer 2C10 Pancreas 1.11E-03 5.85E-01 1.28E+00
Parkinson's disease 8A00.0 Substantia nigra tissue 7.26E-01 3.12E-02 8.20E-02
Pediatric respiratory syncytial virus infection CA40.11 Peripheral blood 4.06E-05 5.98E-01 1.37E+00
Pituitary cancer 2D12 Pituitary tissue 6.19E-01 1.56E-01 4.23E-01
Pituitary gonadotrope tumour 2D12 Pituitary tissue 7.36E-01 2.98E-01 7.20E-01
Polycystic ovary syndrome 5A80.1 Vastus lateralis muscle 5.18E-01 4.57E-02 2.97E-01
Polycythemia vera 2A20.4 Whole blood 7.02E-06 -1.82E-01 -9.56E-01
Pompe disease 5C51.3 Biceps muscle 9.01E-03 5.90E-01 4.23E+00
Preterm birth KA21.4Z Myometrium 1.50E-01 -3.87E-01 -9.98E-01
Prostate cancer 2C82 Prostate 4.69E-05 -8.21E-01 -1.05E+00
Psoriasis EA90 Skin 1.03E-03 -1.23E-01 -2.85E-01
Rectal cancer 2B92 Rectal colon tissue 5.83E-02 1.53E-01 9.83E-01
Renal cancer 2C90-2C91 Kidney 5.93E-05 7.04E-01 1.79E+00
Retinoblastoma 2D02.2 Uvea 4.21E-08 2.36E+00 9.45E+00
Rheumatoid arthritis FA20 Synovial tissue 3.17E-19 2.67E+00 1.23E+01
Rhinovirus infection CA42.1 Nasal epithelium tissue 5.70E-02 6.49E-02 2.72E-01
Schizophrenia 6A20 Prefrontal cortex 5.05E-02 1.30E-01 1.21E-01
Schizophrenia 6A20 Superior temporal cortex 5.06E-01 -4.79E-02 -2.11E-01
Scleroderma 4A42.Z Whole blood 1.36E-01 -1.72E-01 -8.98E-01
Seizure 8A60-8A6Z Whole blood 1.00E-02 -2.04E-01 -6.28E-01
Sensitive skin EK0Z Skin 2.76E-01 7.45E-02 6.37E-01
Sepsis with septic shock 1G41 Whole blood 3.10E-12 3.25E-01 7.94E-01
Shwachman-Diamond syndrome 3A70.0 Bone marrow 1.77E-01 2.81E-02 1.16E-01
Sickle cell disease 3A51.0-3A51.3 Peripheral blood 9.88E-01 -7.99E-02 -6.47E-01
Simpson golabi behmel syndrome LD2C Adipose tissue 7.27E-03 2.48E-01 4.41E+00
Sjogren's syndrome 4A43.2 Salivary gland tissue 5.29E-02 2.47E-01 1.09E+00
Skin cancer 2C30-2C3Z Skin 2.00E-15 4.76E-01 8.81E-01
Thrombocythemia 3B63 Whole blood 1.29E-03 -1.16E-01 -5.43E-01
Thrombocytopenia 3B64 Whole blood 8.52E-01 -2.84E-01 -4.35E-01
Thyroid cancer 2D10 Thyroid 1.27E-45 -1.68E+00 -2.57E+00
Tibial muscular dystrophy 8C75 Muscle tissue 2.45E-08 1.11E+00 3.61E+00
Tuberous sclerosis complex LD2D.2 Perituberal tissue 4.33E-02 4.41E-01 1.36E+00
Type 2 diabetes 5A11 Liver tissue 3.45E-02 -3.70E-01 -2.03E+00
Ureter cancer 2C92 Urothelium 5.61E-01 9.24E-02 5.61E-01
Uterine cancer 2C78 Endometrium tissue 1.06E-04 2.98E-01 6.01E-01
Vitiligo ED63.0 Skin 4.61E-02 -2.37E-01 -7.44E-01
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⏷ Show the Full List of Expression Under 107 Diseases

References

1 Characterization of 6-Mercaptopurine Transport by the SLC43A3-Encoded Nucleobase Transporter. Mol Pharmacol. 2019 Jun;95(6):584-596.