Details of the Drug Transporter (DTP)

General Information of Drug Transporter (DTP) (ID: DTJ785O)

DTP Name Sulfate anion transporter 1 (SLC26A1)
Gene Name SLC26A1
UniProt ID
Q9H2B4 (S26A1_HUMAN)
VARIDT ID
DTD0227
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Synonyms CAON; SAT-1; SAT1; SLC26A1; Solute carrier family 26 member 1
DTP Family Sulfate Permease (SULP) Family ;
Tissue Specificity Expressed most abundantly in the kidney andliver, with lower levels in the pancreas, testis, brain, smallintestine, colon, and lung.
Sequence
MDESPEPLQQGRGPVPVRRQRPAPRGLREMLKARLWCSCSCSVLCVRALVQDLLPATRWL
RQYRPREYLAGDVMSGLVIGIILVPQAIAYSLLAGLQPIYSLYTSFFANLIYFLMGTSRH
VSVGIFSLLCLMVGQVVDRELQLAGFDPSQDGLQPGANSSTLNGSAAMLDCGRDCYAIRV
ATALTLMTGLYQVLMGVLRLGFVSAYLSQPLLDGFAMGASVTILTSQLKHLLGVRIPRHQ
GPGMVVLTWLSLLRGAGQANVCDVVTSTVCLAVLLAAKELSDRYRHRLRVPLPTELLVIV
VATLVSHFGQLHKRFGSSVAGDIPTGFMPPQVPEPRLMQRVALDAVALALVAAAFSISLA
EMFARSHGYSVRANQELLAVGCCNVLPAFLHCFATSAALAKSLVKTATGCRTQLSSVVSA
TVVLLVLLALAPLFHDLQRSVLACVIVVSLRGALRKVWDLPRLWRMSPADALVWAGTAAT
CMLVSTEAGLLAGVILSLLSLAGRTQRPRTALLARIGDTAFYEDATEFEGLVPEPGVRVF
RFGGPLYYANKDFFLQSLYSLTGLDAGCMAARRKEGGSETGVGEGGPAQGEDLGPVSTRA
ALVPAAAGFHTVVIDCAPLLFLDAAGVSTLQDLRRDYGALGISLLLACCSPPVRDILSRG
GFLGEGPGDTAEEEQLFLSVHDAVQTARARHRELEATDAHL
Function This transporter mediates sulfate transport with high affinity, oxalate and bicarbonate.
Endogenous Substrate(s) Cl-
TCDB ID
2.A.53.2.16
Gene ID
10861
KEGG Pathway
Chemical carcinogenesis - reactive oxygen species (hsa05208 )
Reactome Pathway
Multifunctional anion exchangers (R-HSA-427601 )
Transport and synthesis of PAPS (R-HSA-174362 )

Molecular Interaction Atlas (MIA) of This DTP

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTP
3 Investigative Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
BICARBONATE DMT5E36 Discovery agent N.A. Investigative [1]
oxalate DM40SEU Discovery agent N.A. Investigative [2]
SULFATE DMW0ZBF Discovery agent N.A. Investigative [2]
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Molecular Expression Atlas (MEA) of This DTP

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DTP
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Acute myelocytic leukaemia 2B33.1 Bone marrow 6.49E-19 1.66E-01 1.00E+00
Adrenocortical carcinoma 2D11.Z Kidney 1.49E-01 -8.94E-02 -2.93E-01
Alopecia ED70 Skin from scalp 4.62E-01 -5.70E-02 -1.60E-01
Alzheimer's disease 8A20 Entorhinal cortex 2.53E-01 2.85E-02 1.78E-01
Ankylosing spondylitis FA92.0 Pheripheral blood 4.17E-01 -1.12E-01 -9.27E-01
Aortic stenosis BB70 Calcified aortic valve 8.68E-01 -1.46E-01 -2.21E-01
Apnea 7A40 Hyperplastic tonsil 9.23E-02 -3.00E-01 -1.12E+00
Arthropathy FA00-FA5Z Peripheral blood 1.51E-01 6.44E-02 5.80E-01
Asthma CA23 Nasal and bronchial airway 8.27E-02 -7.28E-02 -1.51E-01
Atopic dermatitis EA80 Skin 5.47E-01 -1.95E-02 -1.94E-01
Autism 6A02 Whole blood 2.50E-01 -3.84E-02 -1.86E-01
Autoimmune uveitis 9A96 Peripheral monocyte 1.79E-03 -2.43E-01 -2.43E+00
Autosomal dominant monocytopenia 4B04 Whole blood 1.92E-01 -1.26E-01 -1.25E+00
Bacterial infection of gingival 1C1H Gingival tissue 1.32E-04 1.59E-01 7.11E-01
Batten disease 5C56.1 Whole blood 3.33E-01 4.27E-02 5.62E-01
Behcet's disease 4A62 Peripheral blood 3.33E-01 -4.56E-02 -4.16E-01
Bipolar disorder 6A60-6A6Z Prefrontal cortex 7.02E-01 -1.43E-02 -1.05E-01
Bladder cancer 2C94 Bladder tissue 6.37E-02 1.76E-01 8.44E-01
Breast cancer 2C60-2C6Z Breast tissue 5.67E-05 5.64E-02 2.48E-01
Cardioembolic stroke 8B11.20 Whole blood 1.24E-02 -1.45E-01 -7.06E-01
Cervical cancer 2C77 Cervical tissue 4.45E-02 1.08E-01 6.05E-01
Childhood onset rheumatic disease FA20.Z Peripheral blood 7.35E-01 -3.84E-02 -1.47E-01
Chronic hepatitis C 1E51.1 Whole blood 4.67E-01 5.07E-02 2.85E-01
Chronic obstructive pulmonary disease CA22 Lung tissue 4.34E-01 -4.65E-02 -2.62E-01
Chronic obstructive pulmonary disease CA22 Small airway epithelium 1.64E-02 1.80E-01 8.02E-01
Chronic rhinosinusitis CA0A Sinus mucosa tissue 8.45E-01 1.18E-02 7.49E-02
Colon cancer 2B90 Colon tissue 8.83E-03 -7.80E-02 -3.21E-01
Coronary artery disease BA80-BA8Z Peripheral blood 5.88E-01 -3.95E-02 -8.57E-01
Diffuse large B-cell lymphoma 2A81 Tonsil tissue 7.73E-02 3.75E-02 3.08E-01
Endometriosis GA10 Endometrium tissue 5.13E-01 1.63E-02 6.03E-02
Familial hypercholesterolemia 5C80.00 Peripheral blood 9.99E-02 6.32E-02 3.93E-01
Familial hypercholesterolemia 5C80.00 Whole blood 2.58E-01 -9.21E-02 -4.28E-01
Gastric cancer 2B72 Gastric tissue 7.88E-01 -3.47E-02 -2.33E-01
Glioblastopma 2A00.00 Nervous tissue 8.69E-10 -7.29E-02 -3.10E-01
Glioma 2A00.0Y-2A00.0Z White matter tissue 5.88E-04 -2.91E-01 -1.63E+00
Head and neck cancer 2D42 Head and neck tissue 6.53E-01 2.02E-02 1.06E-01
HIV-associated neurocognitive impairment 8A2Y-8A2Z White matter tissue 2.39E-02 -8.92E-02 -8.34E-01
Huntington's disease 8A01.10 Whole blood 3.92E-02 1.14E-01 9.02E-01
Idiopathic pulmonary fibrosis CB03.4 Lung tissue 3.69E-02 7.21E-02 2.24E+00
Immunodeficiency 4A00-4A20 Peripheral blood 3.17E-02 1.06E-01 1.53E+00
Influenza 1.00E+30 Whole blood 1.19E-02 1.81E-01 8.26E+00
Interstitial cystitis GC00.3 Bladder tissue 1.11E-01 1.94E-02 1.09E-01
Intracranial aneurysm 8B01.0 Intracranial artery 9.21E-01 3.39E-02 1.78E-01
Irritable bowel syndrome DD91.0 Rectal colon tissue 1.11E-01 -2.91E-02 -1.65E-01
Ischemic stroke 8B11 Peripheral blood 7.88E-01 1.76E-02 1.05E-01
Juvenile idiopathic arthritis FA24 Peripheral blood 5.22E-02 -1.15E-01 -3.36E-01
Lateral sclerosis 8B60.4 Cervical spinal cord 8.85E-01 -4.44E-02 -2.89E-01
Lateral sclerosis 8B60.4 Skin 4.87E-01 1.27E-01 5.04E-01
Liver cancer 2C12.0 Liver tissue 1.31E-04 -1.52E-01 -7.07E-01
Liver failure DB99.7-DB99.8 Liver tissue 8.68E-01 4.30E-03 2.39E-02
Lung cancer 2C25 Lung tissue 4.63E-02 -1.84E-02 -9.68E-02
Lupus erythematosus 4A40 Whole blood 2.38E-03 -6.89E-02 -2.00E-01
Major depressive disorder 6A70-6A7Z Whole blood 8.21E-01 1.19E-02 6.21E-02
Major depressive disorder 6A70-6A7Z Hippocampus 3.93E-01 6.72E-02 5.03E-01
Melanoma 2C30 Skin 1.61E-01 -1.69E-01 -3.59E-01
Multiple myeloma 2A83.1 Bone marrow 2.45E-02 -1.68E-01 -8.51E-01
Multiple myeloma 2A83.1 Peripheral blood 6.51E-01 -8.98E-03 -5.06E-02
Multiple sclerosis 8A40 Plasmacytoid dendritic cells 9.85E-01 -5.39E-02 -2.05E-01
Myelodysplastic syndrome 2A36-2A3Z Bone marrow 8.40E-02 6.65E-02 4.53E-01
Myelofibrosis 2A20.2 Whole blood 7.95E-01 -6.66E-02 -5.39E-01
Myocardial infarction BA41-BA50 Peripheral blood 4.15E-02 -1.26E-01 -2.98E-01
Myopathy 8C70.6 Muscle tissue 8.48E-04 -1.70E-01 -2.16E+00
Neonatal sepsis KA60 Whole blood 5.65E-01 3.92E-04 1.55E-03
Neuroectodermal tumour 2A00.11 Brain stem tissue 3.18E-02 1.96E-01 7.54E-01
Non-alcoholic fatty liver disease DB92 Liver tissue 6.26E-01 -3.19E-02 -2.75E-01
Obesity related type 2 diabetes 5A11 Omental adipose tissue 4.31E-02 8.06E-02 9.35E-01
Olive pollen allergy CA08.00 Peripheral blood 1.87E-01 2.34E-01 8.25E-01
Oral cancer 2B6E Oral tissue 7.17E-10 -4.29E-01 -1.79E+00
Osteoarthritis FA00-FA0Z Synovial tissue 1.25E-01 -3.12E-01 -6.85E-01
Osteoporosis FB83.1 Bone marrow 8.53E-01 1.70E-02 1.95E-01
Ovarian cancer 2C73 Ovarian tissue 8.87E-02 -1.25E-01 -8.45E-01
Pancreatic cancer 2C10 Pancreas 1.45E-03 -2.20E-01 -7.81E-01
Parkinson's disease 8A00.0 Substantia nigra tissue 8.62E-01 3.42E-02 1.20E-01
Pediatric respiratory syncytial virus infection CA40.11 Peripheral blood 2.50E-02 -9.94E-02 -7.37E-01
Pituitary cancer 2D12 Pituitary tissue 3.68E-01 3.21E-03 1.42E-02
Pituitary gonadotrope tumour 2D12 Pituitary tissue 4.32E-01 -1.13E-01 -5.47E-01
Polycystic ovary syndrome 5A80.1 Vastus lateralis muscle 9.20E-01 -6.21E-02 -1.88E-01
Polycythemia vera 2A20.4 Whole blood 3.48E-07 9.99E-02 8.11E-01
Pompe disease 5C51.3 Biceps muscle 1.36E-01 -1.25E-01 -8.61E-01
Preterm birth KA21.4Z Myometrium 1.99E-01 -1.17E-01 -4.88E-01
Prostate cancer 2C82 Prostate 9.78E-05 7.78E-01 1.49E+00
Psoriasis EA90 Skin 7.53E-05 1.32E-01 4.42E-01
Rectal cancer 2B92 Rectal colon tissue 1.72E-01 -1.93E-01 -1.12E+00
Renal cancer 2C90-2C91 Kidney 3.31E-02 -1.17E-01 -5.43E-01
Retinoblastoma 2D02.2 Uvea 4.43E-01 -2.59E-02 -2.06E-01
Rheumatoid arthritis FA20 Synovial tissue 3.09E-02 -5.40E-01 -1.30E+00
Rhinovirus infection CA42.1 Nasal epithelium tissue 5.77E-01 -2.65E-02 -1.91E-01
Schizophrenia 6A20 Prefrontal cortex 8.07E-02 2.23E-02 8.50E-02
Schizophrenia 6A20 Superior temporal cortex 1.91E-01 -3.32E-02 -2.55E-01
Scleroderma 4A42.Z Whole blood 3.81E-02 1.03E-01 7.06E-01
Seizure 8A60-8A6Z Whole blood 6.15E-01 1.88E-02 1.48E-01
Sensitive skin EK0Z Skin 2.26E-01 6.94E-02 4.23E-01
Sepsis with septic shock 1G41 Whole blood 2.18E-01 -3.92E-02 -1.42E-01
Shwachman-Diamond syndrome 3A70.0 Bone marrow 5.65E-01 -6.81E-02 -3.82E-01
Sickle cell disease 3A51.0-3A51.3 Peripheral blood 2.29E-01 1.97E-01 9.04E-01
Simpson golabi behmel syndrome LD2C Adipose tissue 9.65E-01 -1.35E-02 -1.33E-01
Sjogren's syndrome 4A43.2 Salivary gland tissue 8.91E-01 1.56E-01 4.64E-01
Skin cancer 2C30-2C3Z Skin 4.44E-03 -6.65E-02 -1.97E-01
Thrombocythemia 3B63 Whole blood 2.00E-01 7.52E-02 6.10E-01
Thrombocytopenia 3B64 Whole blood 9.28E-01 -3.06E-02 -6.37E-02
Thyroid cancer 2D10 Thyroid 3.83E-02 2.00E-02 9.53E-02
Tibial muscular dystrophy 8C75 Muscle tissue 1.56E-04 -4.38E-01 -1.65E+00
Tuberous sclerosis complex LD2D.2 Perituberal tissue 5.25E-01 2.10E-01 7.09E-01
Type 2 diabetes 5A11 Liver tissue 6.42E-01 -1.18E-02 -4.82E-02
Ureter cancer 2C92 Urothelium 6.89E-01 2.15E-03 1.30E-02
Uterine cancer 2C78 Endometrium tissue 1.66E-23 2.98E-01 1.45E+00
Vitiligo ED63.0 Skin 6.32E-02 -7.39E-02 -3.93E-01
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⏷ Show the Full List of Expression Under 107 Diseases

References

1 SLC26A Gene Family Participate in pH Regulation during Enamel Maturation. PLoS One. 2015 Dec 15;10(12):e0144703.
2 Mutations in SLC26A1 Cause Nephrolithiasis. Am J Hum Genet. 2016 Jun 2;98(6):1228-1234.