Details of the Drug Transporter (DTP)

General Information of Drug Transporter (DTP) (ID: DTJK135)

DTP Name Glucose transporter type 11 (SLC2A11)
Gene Name SLC2A11
UniProt ID
Q9BYW1 (GTR11_HUMAN)
VARIDT ID
DTD0253
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Synonyms GLUT-11; GLUT11; Glucose transporter type 10; SLC2A11; Solute carrier family 2, facilitated glucose transporter member 11
DTP Family Major Facilitator Superfamily (MFS)
Sugar Porter (SP) Family
Tissue Specificity Expressed in heart and skeletal muscle.
Sequence
MRALRRLIQGRILLLTICAAGIGGTFQFGYNLSIINAPTLHIQEFTNETWQARTGEPLPD
HLVLLMWSLIVSLYPLGGLFGALLAGPLAITLGRKKSLLVNNIFVVSAAILFGFSRKAGS
FEMIMLGRLLVGVNAGVSMNIQPMYLGESAPKELRGAVAMSSAIFTALGIVMGQVVGLRE
LLGGPQAWPLLLASCLVPGALQLASLPLLPESPRYLLIDCGDTEACLAALRRLRGSGDLA
GELEELEEERAACQGCRARRPWELFQHRALRRQVTSLVVLGSAMELCGNDSVYAYASSVF
RKAGVPEAKIQYAIIGTGSCELLTAVVSCVVIERVGRRVLLIGGYSLMTCWGSIFTVALC
LQSSFPWTLYLAMACIFAFILSFGIGPAGVTGILATELFDQMARPAACMVCGALMWIMLI
LVGLGFPFIMEALSHFLYVPFLGVCVCGAIYTGLFLPETKGKTFQEISKELHRLNFPRRA
QGPTWRSLEVIQSTEL
Function This tranporter mediates the transmenbrane of glucose.
Endogenous Substrate(s) Hexoses
TCDB ID
2.A.1.1.44
Gene ID
66035
Reactome Pathway
Cellular hexose transport (R-HSA-189200 )

Molecular Expression Atlas (MEA) of This DTP

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DTP
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Acute myelocytic leukaemia 2B33.1 Bone marrow 1.36E-06 1.43E-01 6.40E-01
Adrenocortical carcinoma 2D11.Z Kidney 3.48E-02 2.10E-01 5.97E-01
Alopecia ED70 Skin from scalp 6.07E-04 -4.43E-01 -9.80E-01
Alzheimer's disease 8A20 Entorhinal cortex 8.03E-01 -7.01E-03 -2.48E-02
Ankylosing spondylitis FA92.0 Pheripheral blood 1.29E-01 3.30E-01 1.16E+00
Aortic stenosis BB70 Calcified aortic valve 3.94E-01 1.71E-01 5.08E-01
Apnea 7A40 Hyperplastic tonsil 4.06E-01 5.66E-02 4.80E-01
Arthropathy FA00-FA5Z Peripheral blood 3.30E-01 -2.00E-02 -1.23E-01
Asthma CA23 Nasal and bronchial airway 1.83E-01 7.05E-02 1.20E-01
Atopic dermatitis EA80 Skin 2.66E-03 -4.01E-01 -1.08E+00
Autism 6A02 Whole blood 5.72E-02 -8.16E-02 -3.39E-01
Autoimmune uveitis 9A96 Peripheral monocyte 4.04E-02 9.43E-02 7.64E-01
Autosomal dominant monocytopenia 4B04 Whole blood 1.92E-01 -4.33E-02 -2.32E-01
Bacterial infection of gingival 1C1H Gingival tissue 1.05E-18 4.53E-01 1.59E+00
Batten disease 5C56.1 Whole blood 7.95E-02 -2.50E-01 -1.33E+00
Behcet's disease 4A62 Peripheral blood 5.86E-01 -7.55E-02 -1.77E-01
Bipolar disorder 6A60-6A6Z Prefrontal cortex 5.23E-01 -2.33E-02 -8.50E-02
Bladder cancer 2C94 Bladder tissue 9.95E-03 -5.58E-01 -1.74E+00
Breast cancer 2C60-2C6Z Breast tissue 3.97E-26 2.83E-01 8.11E-01
Cardioembolic stroke 8B11.20 Whole blood 1.87E-07 -4.73E-01 -1.68E+00
Cervical cancer 2C77 Cervical tissue 8.63E-01 2.57E-02 1.22E-01
Childhood onset rheumatic disease FA20.Z Peripheral blood 9.98E-01 3.39E-02 9.80E-02
Chronic hepatitis C 1E51.1 Whole blood 3.90E-01 3.54E-02 1.76E-01
Chronic obstructive pulmonary disease CA22 Lung tissue 3.24E-01 3.48E-02 1.05E-01
Chronic obstructive pulmonary disease CA22 Small airway epithelium 4.73E-01 -3.13E-02 -1.14E-01
Chronic rhinosinusitis CA0A Sinus mucosa tissue 7.81E-01 -2.29E-02 -1.70E-01
Colon cancer 2B90 Colon tissue 5.60E-03 4.32E-02 1.71E-01
Coronary artery disease BA80-BA8Z Peripheral blood 7.80E-01 -3.38E-02 -2.97E-01
Diffuse large B-cell lymphoma 2A81 Tonsil tissue 2.22E-01 1.15E-01 1.56E-01
Endometriosis GA10 Endometrium tissue 5.51E-02 -3.24E-01 -3.67E-01
Familial hypercholesterolemia 5C80.00 Peripheral blood 7.85E-02 8.41E-02 4.80E-01
Familial hypercholesterolemia 5C80.00 Whole blood 7.75E-03 -3.51E-01 -1.18E+00
Gastric cancer 2B72 Gastric tissue 1.76E-01 -2.11E-01 -1.64E+00
Glioblastopma 2A00.00 Nervous tissue 1.31E-50 -4.02E-01 -9.95E-01
Glioma 2A00.0Y-2A00.0Z White matter tissue 7.02E-01 -2.38E-02 -6.33E-02
Head and neck cancer 2D42 Head and neck tissue 1.31E-03 -1.68E-01 -4.39E-01
HIV-associated neurocognitive impairment 8A2Y-8A2Z White matter tissue 6.38E-01 -2.17E-02 -6.56E-02
Huntington's disease 8A01.10 Whole blood 1.11E-01 1.28E-01 6.83E-01
Idiopathic pulmonary fibrosis CB03.4 Lung tissue 6.62E-04 4.42E-01 2.67E+00
Immunodeficiency 4A00-4A20 Peripheral blood 1.78E-05 -2.36E-01 -2.38E+00
Influenza 1.00E+30 Whole blood 6.48E-02 3.52E-02 3.52E-01
Interstitial cystitis GC00.3 Bladder tissue 3.22E-01 6.35E-02 2.18E-01
Intracranial aneurysm 8B01.0 Intracranial artery 8.93E-01 1.13E-02 2.99E-02
Irritable bowel syndrome DD91.0 Rectal colon tissue 1.89E-01 -6.01E-02 -1.58E-01
Ischemic stroke 8B11 Peripheral blood 7.22E-01 4.32E-03 1.15E-02
Juvenile idiopathic arthritis FA24 Peripheral blood 2.68E-07 -6.63E-01 -1.20E+00
Lateral sclerosis 8B60.4 Cervical spinal cord 9.42E-01 -1.06E-02 -5.70E-02
Lateral sclerosis 8B60.4 Skin 2.19E-01 1.59E-01 6.83E-01
Liver cancer 2C12.0 Liver tissue 2.70E-02 1.17E-01 4.41E-01
Liver failure DB99.7-DB99.8 Liver tissue 4.64E-02 3.69E-01 8.85E-01
Lung cancer 2C25 Lung tissue 2.52E-21 2.21E-01 7.94E-01
Lupus erythematosus 4A40 Whole blood 2.26E-11 -2.57E-01 -7.04E-01
Major depressive disorder 6A70-6A7Z Whole blood 1.32E-01 -6.61E-02 -1.46E-01
Major depressive disorder 6A70-6A7Z Hippocampus 4.76E-01 -7.17E-02 -2.54E-01
Melanoma 2C30 Skin 3.58E-01 -9.96E-02 -1.90E-01
Multiple myeloma 2A83.1 Bone marrow 3.70E-04 3.46E-01 1.91E+00
Multiple myeloma 2A83.1 Peripheral blood 2.54E-01 -2.43E-02 -1.92E-01
Multiple sclerosis 8A40 Plasmacytoid dendritic cells 4.80E-01 -3.99E-01 -4.77E-01
Myelodysplastic syndrome 2A36-2A3Z Bone marrow 2.50E-02 2.91E-01 7.90E-01
Myelofibrosis 2A20.2 Whole blood 4.66E-03 -2.86E-01 -1.44E+00
Myocardial infarction BA41-BA50 Peripheral blood 1.84E-01 -8.72E-02 -1.58E-01
Myopathy 8C70.6 Muscle tissue 6.37E-01 -6.55E-02 -2.57E-01
Neonatal sepsis KA60 Whole blood 1.91E-16 -3.68E-01 -1.29E+00
Neuroectodermal tumour 2A00.11 Brain stem tissue 3.62E-01 2.33E-01 7.65E-01
Non-alcoholic fatty liver disease DB92 Liver tissue 3.20E-01 1.36E-01 7.48E-01
Obesity related type 2 diabetes 5A11 Omental adipose tissue 2.63E-01 1.36E-01 9.66E-01
Olive pollen allergy CA08.00 Peripheral blood 1.18E-01 6.92E-02 7.16E-01
Oral cancer 2B6E Oral tissue 9.22E-01 2.23E-03 7.97E-03
Osteoarthritis FA00-FA0Z Synovial tissue 9.54E-01 -5.63E-03 -2.50E-02
Osteoporosis FB83.1 Bone marrow 2.51E-01 2.63E-01 7.04E-01
Ovarian cancer 2C73 Ovarian tissue 7.56E-01 -4.33E-02 -1.16E-01
Pancreatic cancer 2C10 Pancreas 1.45E-03 -5.62E-01 -1.12E+00
Parkinson's disease 8A00.0 Substantia nigra tissue 9.78E-01 -9.73E-02 -3.08E-01
Pediatric respiratory syncytial virus infection CA40.11 Peripheral blood 4.91E-02 -1.05E-01 -7.01E-01
Pituitary cancer 2D12 Pituitary tissue 4.17E-01 -2.28E-01 -4.69E-01
Pituitary gonadotrope tumour 2D12 Pituitary tissue 2.28E-01 9.34E-02 2.22E-01
Polycystic ovary syndrome 5A80.1 Vastus lateralis muscle 3.11E-01 2.82E-02 1.84E-01
Polycythemia vera 2A20.4 Whole blood 2.90E-10 -2.01E-01 -1.13E+00
Pompe disease 5C51.3 Biceps muscle 1.89E-02 -2.53E-01 -1.08E+00
Preterm birth KA21.4Z Myometrium 9.75E-03 4.80E-01 1.92E+00
Prostate cancer 2C82 Prostate 3.53E-02 -2.44E-01 -5.37E-01
Psoriasis EA90 Skin 3.10E-22 -5.38E-01 -1.56E+00
Rectal cancer 2B92 Rectal colon tissue 1.45E-01 -3.12E-01 -1.14E+00
Renal cancer 2C90-2C91 Kidney 1.07E-02 -3.30E-01 -7.79E-01
Retinoblastoma 2D02.2 Uvea 2.18E-09 -1.93E+00 -6.65E+00
Rheumatoid arthritis FA20 Synovial tissue 3.09E-05 2.92E-01 2.92E+00
Rhinovirus infection CA42.1 Nasal epithelium tissue 4.72E-02 -5.49E-02 -3.02E-01
Schizophrenia 6A20 Prefrontal cortex 6.02E-01 -1.31E-02 -3.81E-02
Schizophrenia 6A20 Superior temporal cortex 3.69E-01 -5.17E-02 -2.91E-01
Scleroderma 4A42.Z Whole blood 7.24E-01 6.08E-03 3.31E-02
Seizure 8A60-8A6Z Whole blood 7.63E-01 2.01E-02 5.61E-02
Sensitive skin EK0Z Skin 8.90E-01 -1.17E-02 -4.72E-02
Sepsis with septic shock 1G41 Whole blood 8.84E-20 -2.94E-01 -9.68E-01
Shwachman-Diamond syndrome 3A70.0 Bone marrow 4.43E-01 -2.56E-02 -1.43E-01
Sickle cell disease 3A51.0-3A51.3 Peripheral blood 8.31E-02 1.63E-01 1.10E+00
Simpson golabi behmel syndrome LD2C Adipose tissue 6.83E-01 -1.86E-01 -6.12E-01
Sjogren's syndrome 4A43.2 Salivary gland tissue 2.41E-02 -2.42E-01 -1.60E+00
Skin cancer 2C30-2C3Z Skin 2.31E-02 -1.74E-01 -3.71E-01
Thrombocythemia 3B63 Whole blood 1.49E-03 -2.25E-01 -1.11E+00
Thrombocytopenia 3B64 Whole blood 3.33E-01 3.88E-01 4.46E-01
Thyroid cancer 2D10 Thyroid 2.81E-05 2.15E-01 6.75E-01
Tibial muscular dystrophy 8C75 Muscle tissue 2.67E-01 -3.89E-02 -1.03E-01
Tuberous sclerosis complex LD2D.2 Perituberal tissue 4.07E-03 -4.96E-01 -5.58E+00
Type 2 diabetes 5A11 Liver tissue 5.33E-01 -1.22E-01 -4.16E-01
Ureter cancer 2C92 Urothelium 8.21E-01 -1.23E-01 -8.16E-01
Uterine cancer 2C78 Endometrium tissue 5.29E-07 -4.14E-01 -5.09E-01
Vitiligo ED63.0 Skin 3.93E-01 -4.86E-02 -1.44E-01
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