Details of the Drug Transporter (DTP)

General Information of Drug Transporter (DTP) (ID: DTT3IKQ)

• DTP Name: Organic anion transporter 6 (SLC22A20)
• Gene Name: SLC22A20
• UniProt ID: A6NK97 (S22AK_HUMAN)
• VARIDT ID: DTD0145
• Synonyms: SLC22A20; SLC22A20P; OAT6; Solute carrier family 22 member 20; Solute carrier family 22 member 20 pseudogene
• DTP Family:
  Major Facilitator Superfamily (MFS)
  Organic Cation Transporter (OCT) Family
• Sequence:
  MAFTDLLDALGSMGRFQLNHTALLLLPCGLLACHNFLQNFTAAVPPHHCRGPANHTEAST
  NDSGAWLRATIPLDQLGAPEPCRRFTKPQWALLSPNSSIPGAATEGCKDGWVYNRSVFPS
  TIVMEWDLVCEARTLRDLAQSVYMAGVLVGAAVFGSLADRLGCKGPLVWSYLQLAASGAA
  TAYFSSFSAYCVFRFLMGMTFSGIILNSVSLVVEWMPTRGRTVAGILLGYSFTLGQLILA
  GVAYLIRPWRCLQFAISAPFLIFFLYSWWLPESSRWLLLHGKSQLAVQNLQKVAAMNGRK
  EEGERLTKEVMSSYIQSEFASVCTSNSILDLFRTPAIRKVTCCLMVIWFSNSVAYYGLAM
  DLQKFGLSLYLVQALFGIINTPAMLVATATMIYVGRRATVASFLILAGLMVIANMFVPEG
  TQILCTAQAALGKGCLASSFICVYLFTGELYPTEIRQMGMGFASVHARLGGLTAPLVTTL
  GEYSTILPPVSFGATAILAGLAVCVLTETRNMPLVETIAAMERRVKEGSSKKHVEEKSEE
  ISLQQLRASPLKETI
• Function: This transporter is organic anion transporter that mediates the uptake of estrone sulfate.
• Endogenous Substrate(s): Organic anions
• TCDB ID: 2.A.1.19.35
• Gene ID: 440044

Molecular Interaction Atlas (MIA) of This DTP

1 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estrone sulfate	DMVBIZL	Atrophic vaginitis	GA30.2	Approved	[1]

The Drug Therapeutic Target (DTT) Role of This DTP

• DTP DTT Name: Organic anion transporter 6 DTT Info

References

• [1] Transport of estrone sulfate by the novel organic anion transporter Oat6 (Slc22a20). Am J Physiol Renal Physiol. 2006 Aug;291(2):F314-21.