Details of the Drug Transporter (DTP)

General Information of Drug Transporter (DTP) (ID: DTT82QK)

DTP Name Mitochondrial thiamine pyrophosphate carrier (SLC25A19)
Gene Name SLC25A19
UniProt ID
Q9HC21 (TPC_HUMAN)
VARIDT ID
DTD0178
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Synonyms DNC; MCPHA; MUP1; Mitochondrial uncoupling protein 1; SLC25A19; Solute carrier family 25 member 19; THMD3; THMD4; TPC
DTP Family Mitochondrial Carrier (MC) Family ;
Tissue Specificity Expressed in all tissues examined except forplacenta. Highest levels in colon, kidney, lung, testis, spleen,and brain.
Sequence
MVGYDPKPDGRNNTKFQVAVAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYH
GILQASRQILQEEGPTAFWKGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSV
HFVCGGLAACMATLTVHPVDVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAP
TLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNENLQNLLCGSGAGVISKTLTYPLDLF
KKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMF
FSYEFFCNVFHCMNRTASQR
Function This transporter is mitochondrial transporter mediating uptake of thiamine pyrophosphate (ThPP) into mitochondria.
Endogenous Substrate(s) dNDPs; dNTPs
TCDB ID
2.A.29.16.1
Gene ID
60386
Reactome Pathway
Vitamin B1 (thiamin) metabolism (R-HSA-196819 )

Molecular Interaction Atlas (MIA) of This DTP

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTP
1 Investigative Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Thiamine pyrophosphate DM5WYJ6 N. A. N. A. Investigative [1]
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Molecular Expression Atlas (MEA) of This DTP

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DTP
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Acute myelocytic leukaemia 2B33.1 Bone marrow 2.52E-06 1.07E-01 3.35E-01
Adrenocortical carcinoma 2D11.Z Kidney 1.21E-03 -6.39E-01 -8.48E-01
Alopecia ED70 Skin from scalp 3.42E-02 6.58E-02 1.84E-01
Alzheimer's disease 8A20 Entorhinal cortex 7.39E-01 -1.85E-02 -1.32E-01
Ankylosing spondylitis FA92.0 Pheripheral blood 7.07E-01 1.61E-01 3.66E-01
Aortic stenosis BB70 Calcified aortic valve 1.56E-01 1.77E-01 9.52E-01
Apnea 7A40 Hyperplastic tonsil 8.99E-01 1.83E-02 5.36E-02
Arthropathy FA00-FA5Z Peripheral blood 7.59E-02 -8.28E-02 -4.52E-01
Asthma CA23 Nasal and bronchial airway 5.72E-01 1.42E-02 3.48E-02
Atopic dermatitis EA80 Skin 2.43E-07 3.51E-01 1.69E+00
Autism 6A02 Whole blood 4.01E-01 -2.05E-02 -7.69E-02
Autoimmune uveitis 9A96 Peripheral monocyte 6.98E-01 -3.82E-01 -1.10E+00
Autosomal dominant monocytopenia 4B04 Whole blood 4.50E-01 -2.95E-02 -1.60E-01
Bacterial infection of gingival 1C1H Gingival tissue 1.55E-13 3.29E-01 1.35E+00
Batten disease 5C56.1 Whole blood 4.73E-01 4.16E-02 4.07E-01
Behcet's disease 4A62 Peripheral blood 9.44E-01 -1.96E-02 -1.16E-01
Bipolar disorder 6A60-6A6Z Prefrontal cortex 9.40E-01 1.37E-02 1.15E-01
Bladder cancer 2C94 Bladder tissue 4.24E-06 6.04E-01 3.50E+00
Breast cancer 2C60-2C6Z Breast tissue 1.19E-94 6.51E-01 1.79E+00
Cardioembolic stroke 8B11.20 Whole blood 2.50E-03 1.45E-01 6.35E-01
Cervical cancer 2C77 Cervical tissue 5.94E-04 3.15E-01 1.13E+00
Childhood onset rheumatic disease FA20.Z Peripheral blood 4.18E-01 9.46E-03 2.92E-02
Chronic hepatitis C 1E51.1 Whole blood 3.94E-01 1.26E-01 3.79E-01
Chronic obstructive pulmonary disease CA22 Lung tissue 5.83E-01 5.43E-03 1.84E-02
Chronic obstructive pulmonary disease CA22 Small airway epithelium 2.45E-04 1.94E-01 8.13E-01
Chronic rhinosinusitis CA0A Sinus mucosa tissue 4.79E-01 1.01E-02 6.78E-02
Colon cancer 2B90 Colon tissue 7.56E-28 3.38E-01 1.26E+00
Coronary artery disease BA80-BA8Z Peripheral blood 6.37E-01 6.33E-02 1.12E-01
Diffuse large B-cell lymphoma 2A81 Tonsil tissue 9.06E-01 3.13E-02 7.65E-02
Endometriosis GA10 Endometrium tissue 3.75E-02 1.27E-01 2.67E-01
Familial hypercholesterolemia 5C80.00 Peripheral blood 1.64E-01 1.86E-02 1.53E-01
Familial hypercholesterolemia 5C80.00 Whole blood 5.31E-03 2.58E-01 1.68E+00
Gastric cancer 2B72 Gastric tissue 3.69E-01 7.65E-01 1.12E+00
Glioblastopma 2A00.00 Nervous tissue 4.60E-01 -2.97E-02 -1.05E-01
Glioma 2A00.0Y-2A00.0Z White matter tissue 2.68E-03 1.18E+00 1.62E+00
Head and neck cancer 2D42 Head and neck tissue 3.02E-08 1.30E-01 5.08E-01
HIV-associated neurocognitive impairment 8A2Y-8A2Z White matter tissue 3.99E-02 7.87E-02 5.29E-01
Huntington's disease 8A01.10 Whole blood 2.77E-01 1.73E-01 6.55E-01
Idiopathic pulmonary fibrosis CB03.4 Lung tissue 4.92E-01 -1.03E-01 -4.33E-01
Immunodeficiency 4A00-4A20 Peripheral blood 8.13E-03 1.02E-01 9.98E-01
Influenza 1.00E+30 Whole blood 3.26E-02 -1.29E+00 -2.91E+00
Interstitial cystitis GC00.3 Bladder tissue 2.06E-05 6.66E-01 5.23E+00
Intracranial aneurysm 8B01.0 Intracranial artery 2.87E-02 4.44E-01 4.67E+00
Irritable bowel syndrome DD91.0 Rectal colon tissue 3.54E-01 -2.45E-01 -5.35E-01
Ischemic stroke 8B11 Peripheral blood 6.13E-01 -3.09E-02 -1.29E-01
Juvenile idiopathic arthritis FA24 Peripheral blood 6.12E-11 -7.09E-01 -1.39E+00
Lateral sclerosis 8B60.4 Cervical spinal cord 3.36E-01 1.45E-01 5.12E-01
Lateral sclerosis 8B60.4 Skin 4.91E-02 2.72E-01 1.31E+00
Liver cancer 2C12.0 Liver tissue 2.39E-13 2.75E-01 1.18E+00
Liver failure DB99.7-DB99.8 Liver tissue 5.14E-04 7.45E-01 1.93E+00
Lung cancer 2C25 Lung tissue 1.58E-07 1.82E-01 5.28E-01
Lupus erythematosus 4A40 Whole blood 1.12E-03 -1.28E-01 -2.45E-01
Major depressive disorder 6A70-6A7Z Whole blood 6.21E-01 -1.54E-01 -3.72E-01
Major depressive disorder 6A70-6A7Z Hippocampus 7.94E-01 5.02E-03 4.52E-02
Melanoma 2C30 Skin 1.86E-02 3.25E-01 5.87E-01
Multiple myeloma 2A83.1 Bone marrow 7.89E-04 3.54E-01 1.52E+00
Multiple myeloma 2A83.1 Peripheral blood 6.36E-01 -2.84E-01 -5.05E-01
Multiple sclerosis 8A40 Plasmacytoid dendritic cells 6.85E-01 -9.22E-03 -4.02E-02
Myelodysplastic syndrome 2A36-2A3Z Bone marrow 4.59E-04 2.19E-01 4.97E-01
Myelofibrosis 2A20.2 Whole blood 1.95E-02 -1.66E-01 -1.66E+00
Myocardial infarction BA41-BA50 Peripheral blood 7.30E-01 -1.94E-01 -3.58E-01
Myopathy 8C70.6 Muscle tissue 6.55E-01 4.10E-02 1.89E-01
Neonatal sepsis KA60 Whole blood 8.77E-04 -2.16E-01 -8.75E-01
Neuroectodermal tumour 2A00.11 Brain stem tissue 5.50E-02 1.39E-01 5.11E-01
Non-alcoholic fatty liver disease DB92 Liver tissue 4.85E-01 -4.79E-02 -2.06E-01
Obesity related type 2 diabetes 5A11 Omental adipose tissue 3.15E-01 -2.23E-01 -7.67E-01
Olive pollen allergy CA08.00 Peripheral blood 9.54E-01 7.25E-02 1.21E-01
Oral cancer 2B6E Oral tissue 7.71E-02 1.27E-01 3.78E-01
Osteoarthritis FA00-FA0Z Synovial tissue 4.95E-02 2.89E-01 1.07E+00
Osteoporosis FB83.1 Bone marrow 3.26E-01 1.41E-01 6.69E-01
Ovarian cancer 2C73 Ovarian tissue 1.46E-01 6.75E-01 7.86E-01
Pancreatic cancer 2C10 Pancreas 1.91E-01 -2.46E-01 -6.58E-01
Parkinson's disease 8A00.0 Substantia nigra tissue 2.43E-02 1.61E-01 5.65E-01
Pediatric respiratory syncytial virus infection CA40.11 Peripheral blood 3.20E-02 1.85E-01 1.16E+00
Pituitary cancer 2D12 Pituitary tissue 5.85E-01 1.18E-02 2.85E-02
Pituitary gonadotrope tumour 2D12 Pituitary tissue 4.49E-01 -1.28E-01 -2.31E-01
Polycystic ovary syndrome 5A80.1 Vastus lateralis muscle 4.19E-01 -2.61E-02 -2.06E-01
Polycythemia vera 2A20.4 Whole blood 1.47E-09 -1.18E-01 -1.24E+00
Pompe disease 5C51.3 Biceps muscle 1.05E-01 1.56E-01 6.82E-01
Preterm birth KA21.4Z Myometrium 4.30E-01 -5.15E-02 -8.25E-02
Prostate cancer 2C82 Prostate 3.79E-01 -1.57E-01 -3.87E-01
Psoriasis EA90 Skin 2.66E-09 2.11E-01 8.54E-01
Rectal cancer 2B92 Rectal colon tissue 5.81E-01 9.99E-02 4.01E-01
Renal cancer 2C90-2C91 Kidney 5.40E-02 2.11E-01 8.88E-01
Retinoblastoma 2D02.2 Uvea 1.28E-05 6.58E-01 3.17E+00
Rheumatoid arthritis FA20 Synovial tissue 3.27E-01 -2.10E-02 -1.30E-01
Rhinovirus infection CA42.1 Nasal epithelium tissue 1.42E-01 3.78E-02 2.81E-01
Schizophrenia 6A20 Prefrontal cortex 1.73E-01 1.08E-01 2.77E-01
Schizophrenia 6A20 Superior temporal cortex 9.87E-01 -3.38E-02 -3.49E-01
Scleroderma 4A42.Z Whole blood 9.13E-04 1.82E-01 1.53E+00
Seizure 8A60-8A6Z Whole blood 7.15E-01 -3.01E-03 -1.42E-02
Sensitive skin EK0Z Skin 6.83E-01 4.92E-02 2.19E-01
Sepsis with septic shock 1G41 Whole blood 3.27E-05 -1.09E-01 -4.72E-01
Shwachman-Diamond syndrome 3A70.0 Bone marrow 7.88E-01 1.73E-01 5.16E-01
Sickle cell disease 3A51.0-3A51.3 Peripheral blood 6.03E-01 -2.80E-02 -1.06E-01
Simpson golabi behmel syndrome LD2C Adipose tissue 2.27E-01 7.63E-02 3.86E-01
Sjogren's syndrome 4A43.2 Salivary gland tissue 5.24E-01 -4.01E-01 -9.93E-01
Skin cancer 2C30-2C3Z Skin 1.51E-54 6.95E-01 2.10E+00
Thrombocythemia 3B63 Whole blood 2.16E-01 -1.36E-02 -1.29E-01
Thrombocytopenia 3B64 Whole blood 4.62E-01 6.42E-01 5.10E-01
Thyroid cancer 2D10 Thyroid 2.27E-06 2.68E-01 5.83E-01
Tibial muscular dystrophy 8C75 Muscle tissue 7.02E-03 -1.70E-01 -6.87E-01
Tuberous sclerosis complex LD2D.2 Perituberal tissue 5.61E-01 2.45E-03 3.63E-02
Type 2 diabetes 5A11 Liver tissue 2.00E-01 -1.10E-01 -7.28E-01
Ureter cancer 2C92 Urothelium 8.39E-01 -2.12E-02 -7.43E-02
Uterine cancer 2C78 Endometrium tissue 3.23E-03 2.81E-01 5.47E-01
Vitiligo ED63.0 Skin 1.60E-01 7.71E-02 3.07E-01
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⏷ Show the Full List of Expression Under 107 Diseases

References

1 Knockout of Slc25a19 causes mitochondrial thiamine pyrophosphate depletion, embryonic lethality, CNS malformations, and anemia. Proc Natl Acad Sci U S A. 2006 Oct 24;103(43):15927-32.