Details of the Drug Transporter (DTP)

General Information of Drug Transporter (DTP) (ID: DTU8PXI)

• DTP Name: Sodium/hydrogen exchanger 4 (SLC9A4)
• Gene Name: SLC9A4
• UniProt ID: Q6AI14 (SL9A4_HUMAN)
• VARIDT ID: DTD0488
• Synonyms: NHE-4; NHE4; Na(+)/H(+) exchanger 4; SLC9A4; Solute carrier family 9 member 4
• DTP Family: Monovalent Cation:Proton Antiporter-1 (CPA1) family
• Sequence:
  MALQMFVTYSPWNCLLLLVALECSEASSDLNESANSTAQYASNAWFAAASSEPEEGISVF
  ELDYDYVQIPYEVTLWILLASLAKIGFHLYHRLPGLMPESCLLILVGALVGGIIFGTDHK
  SPPVMDSSIYFLYLLPPIVLEGGYFMPTRPFFENIGSILWWAVLGALINALGIGLSLYLI
  CQVKAFGLGDVNLLQNLLFGSLISAVDPVAVLAVFEEARVNEQLYMMIFGEALLNDGITV
  VLYNMLIAFTKMHKFEDIETVDILAGCARFIVVGLGGVLFGIVFGFISAFITRFTQNISA
  IEPLIVFMFSYLSYLAAETLYLSGILAITACAVTMKKYVEENVSQTSYTTIKYFMKMLSS
  VSETLIFIFMGVSTVGKNHEWNWAFICFTLAFCQIWRAISVFALFYISNQFRTFPFSIKD
  QCIIFYSGVRGAGSFSLAFLLPLSLFPRKKMFVTATLVVIYFTVFIQGITVGPLVRYLDV
  KKTNKKESINEELHIRLMDHLKAGIEDVCGHWSHYQVRDKFKKFDHRYLRKILIRKNLPK
  SSIVSLYKKLEMKQAIEMVETGILSSTAFSIPHQAQRIQGIKRLSPEDVESIRDILTSNM
  YQVRQRTLSYNKYNLKPQTSEKQAKEILIRRQNTLRESMRKGHSLPWGKPAGTKNIRYLS
  YPYGNPQSAGRDTRAAGFSDDDSSDPGSPSITFSACSRIGSLQKQEAQEIIPMKSLHRGR
  KAFSFGYQRNTSQEEYLGGVRRVALRPKPLFHAVDEEGESGGESEGKASLVEVRSRWTAD
  HGHGRDHHRSHSPLLQKK
• Function: This transporter mediates and participates in regulating pH value to eliminate acids generated by active metabolism or to combat adverse environmental conditions. May play a special role in kidney, regulating cell volume to cope with extreme fluctuations of hypertonic stimulation cell contraction.
• Endogenous Substrate(s): Na+; H+
• TCDB ID: 2.A.36.1.18
• Gene ID: 389015
• KEGG Pathway: Gastric acid secretion (hsa04971)
• Reactome Pathway: Sodium/Proton exchangers (R-HSA-425986)