Details of the Drug Transporter (DTP)

General Information of Drug Transporter (DTP) (ID: DTV8E46)

• DTP Name: Voltage-dependent L-type calcium channel beta-4 (CACNB4)
• Gene Name: CACNB4
• UniProt ID: O00305 (CACB4_HUMAN)
• VARIDT ID: DTD0522
• Synonyms: CAB4; CACNB4; CACNLB4; Calcium channel voltage-dependent subunit beta 4; EA5; EIG9; EJM; EJM4; EJM6; Voltage-dependent L-type calcium channel subunit beta-4
• DTP Family: Ca(2+) Channel Auxiliary Subunit Beta Types 1-4 (CCA-Beta) Family
• Tissue Specificity: Expressed predominantly in the cerebellum andkidney.
• Sequence:
  MSSSSYAKNGTADGPHSPTSQVARGTTTRRSRLKRSDGSTTSTSFILRQGSADSYTSRPS
  DSDVSLEEDREAIRQEREQQAAIQLERAKSKPVAFAVKTNVSYCGALDEDVPVPSTAISF
  DAKDFLHIKEKYNNDWWIGRLVKEGCEIGFIPSPLRLENIRIQQEQKRGRFHGGKSSGNS
  SSSLGEMVSGTFRATPTSTAKQKQKVTEHIPPYDVVPSMRPVVLVGPSLKGYEVTDMMQK
  ALFDFLKHRFDGRISITRVTADISLAKRSVLNNPSKRAIIERSNTRSSLAEVQSEIERIF
  ELARSLQLVVLDADTINHPAQLIKTSLAPIIVHVKVSSPKVLQRLIKSRGKSQSKHLNVQ
  LVAADKLAQCPPEMFDVILDENQLEDACEHLGEYLEAYWRATHTTSSTPMTPLLGRNLGS
  TALSPYPTAISGLQSQRMRHSNHSTENSPIERRSLMTSDENYHNERARKSRNRLSSSSQH
  SRDHYPLVEEDYPDSYQDTYKPHRNRGSPGGYSHDSRHRL
• Function: The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
• Endogenous Substrate(s): Ca2+
• TCDB ID: 8.A.22.1.4
• Gene ID: 785
• KEGG Pathway:
  MAPK signaling pathway (hsa04010)
  Cardiac muscle contraction (hsa04260)
  Adrenergic signaling in cardiomyocytes (hsa04261)
  Oxytocin signaling pathway (hsa04921)
  Hypertrophic cardiomyopathy (hsa05410)
  Arrhythmogenic right ventricular cardiomyopathy (hsa05412)
  Dilated cardiomyopathy (hsa05414)
• Reactome Pathway:
  NCAM1 interactions (R-HSA-419037)
  Presynaptic depolarization and calcium channel opening (R-HSA-112308)