| DTP Name |
RalBP1-associated Eps domain-containing protein 2 (RALBP1)
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| Gene Name |
RALBP1
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| UniProt ID |
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| VARIDT ID |
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| 3D Structure |
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| Synonyms |
POB1; Partner of RalBP1; REPS2; RIP1; RLIP1; RLIP76; RalBP1-interacting protein 2 |
| DTP Family |
Non ABC Multidrug Exporter (N-MDE) Family
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| Tissue Specificity |
Expressed at high levels in the cerebrum, cerebellum, lung, kidney, and testis. Weakly expressed in the kidney. Relatively highly expressed in androgen-dependent as compared to androgen-independent prostate cancer cell lines and xenografts. Isoform 2 is down-regulated during progression of prostate cancer.
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| Sequence |
MEAAAAAAAAAAAAAAAGGGCGSGPPPLLLSEGEQQCYSELFARCAGAAGGGPGSGPPEA
ARVAPGTATAAAGPVADLFRASQLPAETLHQITELCGAKRVGYFGPTQFYIALKLIAAAQ
SGLPVRIESIKCELPLPRFMMSKNDGEIRFGNPAELHGTKVQIPYLTTEKNSFKRMDDED
KQQETQSPTMSPLASPPSSPPHYQRVPLSHGYSKLRSSAEQMHPAPYEARQPLVQPEGSS
SGGPGTKPLRHQASLIRSFSVERELQDNSSYPDEPWRITEEQREYYVNQFRSLQPDPSSF
ISGSVAKNFFTKSKLSIPELSYIWELSDADCDGALTLPEFCAAFHLIVARKNGYPLPEGL
PPTLQPEYLQAAFPKPKWDCQLFDSYSESLPANQQPRDLNRMEKTSVKDMADLPVPNQDV
TSDDKQALKSTINEALPKDVSEDPATPKDSNSLKARPRSRSYSSTSIEEAMKRGEDPPTP
PPRPQKTHSRASSLDLNKVFQPSVPATKSGLLPPPPALPPRPCPSQSEQVSEAELLPQLS
RAPSQAAESSPAKKDVLYSQPPSKPIRRKFRPENQATENQEPSTAASGPASAATMKPHPT
VQKQSSKQKKAIQTAIRKNKEANAVLARLNSELQQQLKEVHQERIALENQLEQLRPVTVL
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| Function |
This tranporter involved in growth factor signaling through its influence on the Ral signaling pathway. |
| TCDB ID |
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| Gene ID |
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| Reactome Pathway |
- Clathrin-mediated endocytosis (R-HSA-8856828 )
- Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825 )
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