Details of the Drug Transporter (DTP)

General Information of Drug Transporter (DTP) (ID: DTZOKFJ)

DTP Name	Monocarboxylate transporter 12 (SLC16A12)
Gene Name	SLC16A12
UniProt ID	Q6ZSM3 (MOT12_HUMAN)
VARIDT ID	DTD0103
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Synonyms	CJMG; CRT2; CTRCT47; Creatine transporter 2; MCT 12; MCT12; SLC16A12; Solute carrier family 16 member 12
DTP Family	Major Facilitator Superfamily (MFS)
DTP Family	Monocarboxylate Transporter (MCT) Family
Tissue Specificity	Most highly expressed in kidney, followed byretina, lung, heart and testis. Very weakly expressed in brain andliver. Also detected in lens.
Sequence	MPSGSHWTANSSKIITWLLEQPGKEEKRKTMAKVNRARSTSPPDGGWGWMIVAGCFLVTI CTRAVTRCISIFFVEFQTYFTQDYAQTAWIHSIVDCVTMLCAPLGSVVSNHLSCQVGIML GGLLASTGLILSSFATSLKHLYLTLGVLTGLGFALCYSPAIAMVGKYFSRRKALAYGIAM SGSGIGTFILAPVVQLLIEQFSWRGALLILGGFVLNLCVCGALMRPITLKEDHTTPEQNH VCRTQKEDIKRVSPYSSLTKEWAQTCLCCCLQQEYSFLLMSDFVVLAVSVLFMAYGCSPL FVYLVPYALSVGVSHQQAAFLMSILGVIDIIGNITFGWLTDRRCLKNYQYVCYLFAVGMD GLCYLCLPMLQSLPLLVPFSCTFGYFDGAYVTLIPVVTTEIVGTTSLSSALGVVYFLHAV PYLVSPPIAGRLVDTTGSYTAAFLLCGFSMIFSSVLLGFARLIKRMRKTQLQFIAKESDP KLQLWTNGSVAYSVARELDQKHGEPVATAVPGYSLT
Function	This transporter is proton-linked monocarboxylate transporter that mediates creatine transport across the plasma membrane.
Endogenous Substrate(s)	Monocarboxylates
TCDB ID	2.A.1.13.14
Gene ID	387700

Molecular Interaction Atlas (MIA) of This DTP

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTP

1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Creatine ALS-08	DMKD2BQ	Motor neurone disease	8B60	Phase 3	[1]
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References

1	Mutation in the Monocarboxylate Transporter 12 Gene Affects Guanidinoacetate Excretion but Does Not Cause Glucosuria. J Am Soc Nephrol. 2016 May;27(5):1426-36.