Details of the Drug Transporter (DTP)

General Information of Drug Transporter (DTP) (ID: DTZQNP7)

• DTP Name: Voltage-dependent calcium channel alpha-2/delta-3 (CACNA2D3)
• Gene Name: CACNA2D3
• UniProt ID: Q9NY16 (CA2D3_HUMAN)
• VARIDT ID: DTD0521
• Synonyms: CACNA2D3; HSA272268; Voltage-dependent calcium channel subunit alpha-2-3; Voltage-dependent calcium channel subunit delta-3; Voltage-gated calcium channel subunit alpha-2/delta-3; Voltage-dependent calcium channel subunit alpha-2/delta-3
• DTP Family: Ca(2+) Channel Auxiliary Subunit Alpha2Delta Types 1-4 (CCA-Alpha2Delta) Family
• Tissue Specificity: Only detected in brain. Not present in lung,testis, aorta, spleen, jejunum, ventricular muscle and kidney (atprotein level). According to PubMed:11687876, it is brain-specific, while according to PubMed:11245980, it is widelyexpressed.
• Sequence:
  MAGPGSPRRASRGASALLAAALLYAALGDVVRSEQQIPLSVVKLWASAFGGEIKSIAAKY
  SGSQLLQKKYKEYEKDVAIEEIDGLQLVKKLAKNMEEMFHKKSEAVRRLVEAAEEAHLKH
  EFDADLQYEYFNAVLINERDKDGNFLELGKEFILAPNDHFNNLPVNISLSDVQVPTNMYN
  KDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFD
  CRNRKWYIQAATSPKDVVILVDVSGSMKGLRLTIAKQTVSSILDTLGDDDFFNIIAYNEE
  LHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIGMLDIALNEAFNILSDFNHTGQGSI
  CSQAIMLITDGAVDTYDTIFAKYNWPDRKVRIFTYLIGREAAFADNLKWMACANKGFFTQ
  ISTLADVQENVMEYLHVLSRPKVIDQEHDVVWTEAYIDSTLPQAQKLTDDQGPVLMTTVA
  MPVFSKQNETRSKGILLGVVGTDVPVKELLKTIPKYKLGIHGYAFAITNNGYILTHPELR
  LLYEEGKKRRKPNYSSVDLSEVEWEDRDDVLRNAMVNRKTGKFSMEVKKTVDKGKRVLVM
  TNDYYYTDIKGTPFSLGVALSRGHGKYFFRGNVTIEEGLHDLEHPDVSLADEWSYCNTDL
  HPEHRHLSQLEAIKLYLKGKEPLLQCDKELIQEVLFDAVVSAPIEAYWTSLALNKSENSD
  KGVEVAFLGTRTGLSRINLFVGAEQLTNQDFLKAGDKENIFNADHFPLWYRRAAEQIPGS
  FVYSIPFSTGPVNKSNVVTASTSIQLLDERKSPVVAAVGIQMKLEFFQRKFWTASRQCAS
  LDGKCSISCDDETVNCYLIDNNGFILVSEDYTQTGDFFGEIEGAVMNKLLTMGSFKRITL
  YDYQAMCRANKESSDGAHGLLDPYNAFLSAVKWIMTELVLFLVEFNLCSWWHSDMTAKAQ
  KLKQTLEPCDTEYPAFVSERTIKETTGNIACEDCSKSFVIQQIPSSNLFMVVVDSSCLCE
  SVAPITMAPIEIRYNESLKCERLKAQKIRRRPESCHGFHPEENARECGGAPSLQAQTVLL
  LLPLLLMLFSR
• Function: The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel.
• Endogenous Substrate(s): Ca2+
• TCDB ID: 8.A.18.3.1
• Gene ID: 55799

The Drug Therapeutic Target (DTT) Role of This DTP

• DTP DTT Name: Voltage-gated calcium channel alpha-2/delta-3 (CACNA2D3) DTT Info
• DTP DTT Type: Literature-reported

2 Investigative Drug(s) Targeting This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
3-Aminomethyl-5-methyl-hexanoic acid	DMTYXH1	Discovery agent	N.A.	Investigative	[1]
PD-144550	DM03526	Discovery agent	N.A.	Investigative	[1]

References

• [1] Enantioselective synthesis of PD144723: a potent stereospecific anticonvulsant, Bioorg. Med. Chem. Lett. 4(6):823-826 (1994).