Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT0F26C)

DTT Name	Cytochrome c oxidase copper chaperone (COX17)
Synonyms	Cytochrome c oxidase assembly protein COX17; COX17; CCO assembly protein COX17
Gene Name	COX17
DTT Type	Literature-reported target	[1]
UniProt ID	COX17_HUMAN
TTD ID	T03409
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MPGLVDSNPAPPESQEKKPLKPCCACPETKKARDACIIEKGEEHCGHLIEAHKECMRALG FKI
Function	Copper chaperone for cytochromec oxidase (COX). Binds two copper ions and deliver them to the Cu(A) site of COX.
KEGG Pathway	Oxidative phosphorylation (hsa00190 ) Metabolic pathways (hsa01100 ) Thermogenesis (hsa04714 )
Reactome Pathway	Mitochondrial protein import (R-HSA-1268020 )

References

1	Identification of COX17 as a therapeutic target for non-small cell lung cancer. Cancer Res. 2003 Nov 1;63(21):7038-41.