Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT0JPVF)

DTT Name	Bone/cartilage proteoglycan I (BGN)
Synonyms	PGS1; BGN
Gene Name	BGN
DTT Type	Literature-reported target	[1]
BioChemical Class	Small leucine-rich proteoglycan
UniProt ID	PGS1_HUMAN
TTD ID	T26304
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MWPLWRLVSLLALSQALPFEQRGFWDFTLDDGPFMMNDEEASGADTSGVLDPDSVTPTYS AMCPFGCHCHLRVVQCSDLGLKSVPKEISPDTTLLDLQNNDISELRKDDFKGLQHLYALV LVNNKISKIHEKAFSPLRKLQKLYISKNHLVEIPPNLPSSLVELRIHDNRIRKVPKGVFS GLRNMNCIEMGGNPLENSGFEPGAFDGLKLNYLRISEAKLTGIPKDLPETLNELHLDHNK IQAIELEDLLRYSKLYRLGLGHNQIRMIENGSLSFLPTLRELHLDNNKLARVPSGLPDLK LLQVVYLHSNNITKVGVNDFCPMGFGVKRAYYNGISLFNNPVPYWEVQPATFRCVTDRLA IQFGNYKK
Function	May be involved in collagen fiber assembly.
Reactome Pathway	Chondroitin sulfate biosynthesis (R-HSA-2022870 ) Dermatan sulfate biosynthesis (R-HSA-2022923 ) CS/DS degradation (R-HSA-2024101 ) ECM proteoglycans (R-HSA-3000178 ) Defective B4GALT7 causes EDS, progeroid type (R-HSA-3560783 ) Defective B3GAT3 causes JDSSDHD (R-HSA-3560801 ) Defective CHST3 causes SEDCJD (R-HSA-3595172 ) Defective CHST14 causes EDS, musculocontractural type (R-HSA-3595174 ) Defective CHSY1 causes TPBS (R-HSA-3595177 ) Defective B3GALT6 causes EDSP2 and SEMDJL1 (R-HSA-4420332 ) A tetrasaccharide linker sequence is required for GAG synthesis (R-HSA-1971475 )

References

1	Serum Decorin and Biglycan as Potential Biomarkers to Predict PPROM in Early Gestation. Reprod Sci. 2019 Mar 21:1933719119831790.