Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT0NZIC)

• DTT Name: Phenylethanolamine N-methyltransferase (PNMT)
• Synonyms: PNMTase; PENT; Noradrenaline N-methyltransferase
• Gene Name: PNMT
• DTT Type: Literature-reported target; [1]
• UniProt ID: PNMT_HUMAN
• TTD ID: T56496
• EC Number: EC 2.1.1.28
• Sequence:
  MSGADRSPNAGAAPDSAPGQAAVASAYQRFEPRAYLRNNYAPPRGDLCNPNGVGPWKLRC
  LAQTFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPGA
  FNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLPADALVS
  AFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEEVR
  EALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKVGL
• Function: Converts noradrenaline to adrenaline.
• KEGG Pathway:
  Tyrosine metabolism (hsa00350)
  Metabolic pathways (hsa01100)
• Reactome Pathway: Catecholamine biosynthesis (R-HSA-209905)
• BioCyc Pathway: MetaCyc:HS06868-MON

Molecular Interaction Atlas (MIA) of This DTT

1 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
LY134046	DMT0JXC	Discovery agent	N.A.	Investigative	[1]

The Drug-Metabolizing Enzyme (DME) Role of This DTT

• DTT DME Name: Phenylethanolamine N-methyltransferase (PNMT) DME Info
• Gene Name: PNMT

1 Investigative Drug(s) Metabolized by This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Phenylethanolamine	DMQD2IA	N. A.	N. A.	Investigative	[2]

References

• [1] Properties of 8,9-dichloro-2,3,4,5-tetrahydro-1H-2-benzazepine, an inhibitor of norepinephrine N-methyltransferase. Biochem Pharmacol. 1981 Jun 1;30(11):1345-52.
• [2] Structural, mutagenic, and kinetic analysis of the binding of substrates and inhibitors of human phenylethanolamine N-methyltransferase. J Med Chem. 2005 Nov 17;48(23):7243-52.