Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT0O4QL)

DTT Name	Bacterial Beta-ketoacyl-ACP synthase I (Bact fabB)
Synonyms	fabB; KAS I; Condensing enzyme FabB; 3-oxoacyl-[acyl-carrier-protein] synthase I
Gene Name	Bact fabB
DTT Type	Literature-reported target	[1]
BioChemical Class	Acyltransferase
UniProt ID	FABB_ECOL6
TTD ID	T32468
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
EC Number	EC 2.3.1.41
Sequence	MKRAVITGLGIVSSIGNNQQEVLASLREGRSGITFSQELKDSGMRSHVWGNVKLDTTGLI DRKVVRFMSDASIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSGGGSPRFQVFGADAM RGPRGLKAVGPYVVTKAMASGVSACLATPFKIHGVNYSISSACATSAHCIGNAVEQIQLG KQDIVFAGGGEELCWEMACEFDAMGALSTKYNDTPEKASRTYDAHRDGFVIAGGGGMVVV EELEHALARGAHIYAEIVGYGATSDGADMVAPSGEGAVRCMKMAMHGVDTPIDYLNSHGT STPVGDVKELAAIREVFGDKSPAISATKAMTGHSLGAAGVQEAIYSLLMLEHGFIAPSIN IEELDEQAAGLNIVTETTDRELTTVMSNSFGFGGTNATLVMRKLKD
Function	Catalyzes the condensation reactionof fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-acp. Specific for elongation from c-10 to unsaturated c-16 and c-18 fatty acids.
KEGG Pathway	Fatty acid biosynthesis (ecc00061 ) Biotin metabolism (ecc00780 ) Metabolic pathways (ecc01100 ) Fatty acid metabolism (ecc01212 ) Biosynthesis of cofactors (ecc01240 )
BioCyc Pathway	ECOL199310:C2869-MON

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

1 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Thiolactomycin	DMBAWDG	Malaria	1F40-1F45	Investigative	[1]
------------------------------------------------------------------------------------

References

1	Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res. 2012 Jan;40(Database issue):D1128-36.