Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT1AL3P)

• DTT Name: Beta-ketoacyl-ACP synthase (OXSM)
• Synonyms: 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial
• Gene Name: OXSM
• DTT Type: Literature-reported target; [1]
• BioChemical Class: Acyltransferase
• UniProt ID: OXSM_HUMAN
• TTD ID: T86454
• EC Number: EC 2.3.1.41
• Sequence:
  MSNCLQNFLKITSTRLLCSRLCQQLRSKRKFFGTVPISRLHRRVVITGIGLVTPLGVGTH
  LVWDRLIGGESGIVSLVGEEYKSIPCSVAAYVPRGSDEGQFNEQNFVSKSDIKSMSSPTI
  MAIGAAELAMKDSGWHPQSEADQVATGVAIGMGMIPLEVVSETALNFQTKGYNKVSPFFV
  PKILVNMAAGQVSIRYKLKGPNHAVSTACTTGAHAVGDSFRFIAHGDADVMVAGGTDSCI
  SPLSLAGFSRARALSTNSDPKLACRPFHPKRDGFVMGEGAAVLVLEEYEHAVQRRARIYA
  EVLGYGLSGDAGHITAPDPEGEGALRCMAAALKDAGVQPEEISYINAHATSTPLGDAAEN
  KAIKHLFKDHAYALAVSSTKGATGHLLGAAGAVEAAFTTLACYYQKLPPTLNLDCSEPEF
  DLNYVPLKAQEWKTEKRFIGLTNSFGFGGTNATLCIAGL
• Function: May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function.
• KEGG Pathway:
  Fatty acid biosynthesis (hsa00061)
  Biotin metabolism (hsa00780)
  Metabolic pathways (hsa01100)
  Fatty acid metabolism (hsa01212)
  Biosynthesis of cofactors (hsa01240)
• BioCyc Pathway: MetaCyc:HS07707-MON

References

• [1] Structure of the complex between the antibiotic cerulenin and its target, beta-ketoacyl-acyl carrier protein synthase. J Biol Chem. 1999 Mar 5;274(10):6031-4.