Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT1D5X3)

• DTT Name: Pneumocystis jirovecii DNA topoisomerase 2 (PJ top2)
• Synonyms: PJ DNA topoisomerase 2
• Gene Name: PJ top2
• DTT Type: Discontinued target; [1]
• UniProt ID: L0P818_PNEJ8
• TTD ID: T03985
• EC Number: EC 5.6.2.3
• Sequence:
  MLRETSSDDSDMSFSLKRKYTNVSKNIKKIRNADVGFDSERQLCSEIASVGRTISENLSY
  SRHENFSDTVDTIESKNHLLATKTTSEIYQKLSQLEHILKRPDTYIGSIEFTSQHIWVYD
  DNTNAMKYRQVSIVPGLYKIFDEILVNAADNKIRDPNMDTIKVEFSREKNVISIYNNGRG
  IPIEIHNKEKVWIPELIFGHLLTSSNYDDEEKKVTGGRNGYGAKLCNIFSTEFIVETADR
  ATKKTYKQVFLNNMTKKKDPVIKENKKDEEYTRITFKPDLERFGMKEIDSDLESVFKRRV
  YDLAGSVKNVKVFLNGERIKVKSFKQYIEMYLNSDDSENNLKPTIIHEVVNDRWEVAFTV
  SDGQFNQVSFVNSIATTRGGTHVNYVSDQIVLKLIEAVKKKNKNIPIKPFQVKNHIWVFI
  NSLIENPSFDSQTKETLTLKQTAFGSKCILSDDFIKKVLKTPIMEKILDTAQKKADQLMK
  KTDGSKKMRITGLPKLEDANKAGTKEGHKCTLILTEGDSAKSLAMSGIGVVGRDYFGVYP
  LRGKLLNVREASHEQISKNAEINAIKQIMGLQHKKVYTSTSELRYGHLMIMTDQDHDGSH
  IKGLIINYLESSFPSLLEIPGFLIEFITPIVKATKGTQEKTFFTIPEYEYWKESVDNAKG
  WKIKYYKGLGTSYGNDVKKYFSDLDTHLKEFHSIREGDKELIDMAFSKKKADERKEWLRL
  FKPGTYMDHTLDKIPISDFINKELILFSMADNIRSIPSVVDGLKPGQRKVIFGCFKRKLK
  SEIKVAQLSGYISEHTAYHHGEQSLTQTIIGLAQTFVGSNNINLMKPNGQFGTRLQGGKD
  AASPRYIFTELSPLTRKIFVESDDALLNYLNEDGQSIEPLWYVPIIPLILVNGCEGIGTG
  WSSYIPNFNPIDLVNNIRRMMNGEKLEPMHPWYRGFNGSIEKQGDKYKISGCIRQIDDTT
  VEITELPIRFWTQDMKEFLELSVVGSDKVQPFIKDYSEYHTDTVVHFIIKLTEKGMAESL
  AQGLEEKFKLIKIQNMTNMVAFDSSGRIKKYNSVEEILLEFYNIRLQFYQKRKDYLVNEL
  ESQYNKLSNQVRFVKMVINKEQDFLNRKRKDLLDDLKLKGFIPFPKNKHISVDNATETSN
  NLAENDDDDATGYDYLLSMPLWSLTAEKVEKLLKDKLDKENELESLLKLTVKDLWNKDLD
  NFVEEWEMFLKHDENLTSKVKNLKKDKRNSQKLGIVTQKSVVKKRAVNSQNKPSDVDYKP
  FSKKTLLSAKQTTLPFSVKNVKDTDVDFLKNQESSNKVINESVVAVENDQVFAKTDATAE
  RKYGANAIIVPSLKGDLSDDSDTDYMDDLVKKYTINPSGGKSMTSYIKSVSPSPKKTKIA
  LSTKSRSPPKMSTLLDSSPDYVVPITKSSTKTIHKKKKTLARKININDSEIDIPVRSDIS
  QRPRRQVAVQARQRVVAIINSDDNDTTLDRSSLSSEFDGSSS
• Function: Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.

Molecular Interaction Atlas (MIA) of This DTT

1 Discontinued Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
RG-201	DMW4G68	Acquired immune deficiency syndrome	1C62.3	Discontinued in Phase 1	[1]

References

• [1] US patent application no. 2004,0023,290, Novel therapeutic agents that modulate enzymatic processes.