Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT1FE3L)

• DTT Name: P2Y purinoceptor 13 (P2RY13)
• Synonyms: P2Y13; GPR94; GPR86; G-protein coupled receptor 94; G-protein coupled receptor 86; FKSG77
• Gene Name: P2RY13
• DTT Type: Literature-reported target; [1]
• UniProt ID: P2Y13_HUMAN
• TTD ID: T35664
• Sequence:
  MTAAIRRQRELSILPKVTLEAMNTTVMQGFNRSERCPRDTRIVQLVFPALYTVVFLTGIL
  LNTLALWVFVHIPSSSTFIIYLKNTLVADLIMTLMLPFKILSDSHLAPWQLRAFVCRFSS
  VIFYETMYVGIVLLGLIAFDRFLKIIRPLRNIFLKKPVFAKTVSIFIWFFLFFISLPNTI
  LSNKEATPSSVKKCASLKGPLGLKWHQMVNNICQFIFWTVFILMLVFYVVIAKKVYDSYR
  KSKSKDRKNNKKLEGKVFVVVAVFFVCFAPFHFARVPYTHSQTNNKTDCRLQNQLFIAKE
  TTLFLAATNICMDPLIYIFLCKKFTEKLPCMQGRKTTASSQENHSSQTDNITLG
• Function: Receptor for ADP. Coupled to G(i)-proteins. May play a role in hematopoiesis and the immune system.
• KEGG Pathway: Neuroactive ligand-receptor interaction (hsa04080)
• Reactome Pathway:
  G alpha (i) signalling events (R-HSA-418594)
  P2Y receptors (R-HSA-417957)

Molecular Interaction Atlas (MIA) of This DTT

9 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2MeSADP	DMGADQ1	Discovery agent	N.A.	Investigative	[2]
2MeSAMP	DMBO2DC	Discovery agent	N.A.	Investigative	[2]
2MeSATP	DMUE0W6	Discovery agent	N.A.	Investigative	[2]
adenosine diphosphate	DMFUHKP	N. A.	N. A.	Investigative	[2]
ATPgammaS	DMXHQIN	Discovery agent	N.A.	Investigative	[2]
MRS2211	DM2G5ZE	Discovery agent	N.A.	Investigative	[1]
MRS2603	DMNGC79	Discovery agent	N.A.	Investigative	[1]
PPADS	DMWHN3T	Discovery agent	N.A.	Investigative	[2]
[33P]2MeSADP	DM218VZ	Discovery agent	N.A.	Investigative	[2]

References

• [1] Synthesis of pyridoxal phosphate derivatives with antagonist activity at the P2Y13 receptor. Biochem Pharmacol. 2005 Jul 15;70(2):266-74.
• [2] Pharmacological characterization of the human P2Y13 receptor. Mol Pharmacol. 2003 Jul;64(1):104-12.