Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT1GV6C)

DTT Name DUSP9 messenger RNA (DUSP9 mRNA)
Synonyms Mitogen-activated protein kinase phosphatase 4 (mRNA); MKP4 (mRNA); MKP-4 (mRNA); MAP kinase phosphatase 4 (mRNA); Dual specificity protein phosphatase 9 (mRNA)
Gene Name DUSP9
DTT Type
Literature-reported target
 [1]
BioChemical Class
mRNA target
UniProt ID
DUS9_HUMAN
TTD ID
T00564
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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EC Number
EC 3.1.3.16
Sequence
MEGLGRSCLWLRRELSPPRPRLLLLDCRSRELYESARIGGALSVALPALLLRRLRRGSLS
VRALLPGPPLQPPPPAPVLLYDQGGGRRRRGEAEAEAEEWEAESVLGTLLQKLREEGYLA
YYLQGGFSRFQAECPHLCETSLAGRAGSSMAPVPGPVPVVGLGSLCLGSDCSDAESEADR
DSMSCGLDSEGATPPPVGLRASFPVQILPNLYLGSARDSANLESLAKLGIRYILNVTPNL
PNFFEKNGDFHYKQIPISDHWSQNLSRFFPEAIEFIDEALSQNCGVLVHCLAGVSRSVTV
TVAYLMQKLHLSLNDAYDLVKRKKSNISPNFNFMGQLLDFERSLRLEERHSQEQGSGGQA
SAASNPPSFFTTPTSDGAFELAPT
Function Has a specificity for the ERK family. Inactivates MAP kinases.
KEGG Pathway
MAPK signaling pathway (hsa04010 )
Signaling pathways regulating pluripotency of stem cells (hsa04550 )
Reactome Pathway
Negative regulation of MAPK pathway (R-HSA-5675221 )
RAF-independent MAPK1/3 activation (R-HSA-112409 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
4 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
ISIS 103471 DM86KWU Discovery agent N.A. Investigative [1]
ISIS 103473 DMQRP32 Discovery agent N.A. Investigative [1]
ISIS 103486 DM5BSVQ Discovery agent N.A. Investigative [1]
ISIS 103489 DM6ZME7 Discovery agent N.A. Investigative [1]
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References

1 US patent application no. 6,566,133, Antisense inhibition of dual specific phosphatase 9 expression.